G12 - GPR84 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 75.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 25.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM2 I 59 2x43 G.H5 Q 381 G.H5.26
Van-der-waals TM2 I 59 2x43 G.H5 Q 381 G.H5.26
Polar TM3 H 124 3x56 G.hns1 R 56 G.hns1.03
Hydrophobic TM3 H 124 3x56 G.hns1 R 56 G.hns1.03
Van-der-waals TM3 H 124 3x56 G.hns1 R 56 G.hns1.03
Hydrophobic ECL2 A 211 - G.H5 D 368 G.H5.13
Hydrophobic ECL2 A 208 - G.H5 D 368 G.H5.13
Hydrophobic TM6 F 314 6x30 G.H5 L 375 G.H5.20
Hydrophobic TM3 I 122 3x54 G.H5 I 378 G.H5.23
Polar TM3 R 118 3x50 G.H5 M 379 G.H5.24
Polar H8 N 374 8x47 G.H5 M 379 G.H5.24
Hydrophobic ECL2 V 205 - G.H5 L 375 G.H5.20
Van-der-waals ECL2 V 205 - G.H5 L 375 G.H5.20
Hydrophobic ECL2 L 212 - G.H5 A 365 G.H5.10
Polar H8 N 374 8x47 G.H5 L 380 G.H5.25
Hydrophobic H8 N 374 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 N 374 8x47 G.H5 L 380 G.H5.25
Polar H8 Q 376 8x49 G.H5 L 380 G.H5.25
Hydrophobic H8 Q 376 8x49 G.H5 L 380 G.H5.25
Van-der-waals H8 Q 376 8x49 G.H5 L 380 G.H5.25
Polar TM2 T 53 2x37 G.H5 Q 381 G.H5.26
Hydrophobic TM2 T 53 2x37 G.H5 Q 381 G.H5.26
Van-der-waals TM2 T 53 2x37 G.H5 Q 381 G.H5.26
Hydrophobic TM6 F 314 6x30 G.H5 Q 372 G.H5.17
Van-der-waals TM6 F 314 6x30 G.H5 Q 372 G.H5.17
Hydrophobic TM2 F 55 2x39 G.H5 Q 381 G.H5.26
Hydrophobic TM3 L 121 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 L 121 3x53 G.H5 I 378 G.H5.23
Polar TM5 Y 215 5x31 G.S6 H 349 G.S6.04
Hydrophobic TM5 Y 215 5x31 G.S6 H 349 G.S6.04
Van-der-waals TM5 Y 215 5x31 G.S6 H 349 G.S6.04
Hydrophobic ICL2 P 129 34x54 G.HN R 52 G.HN.52
Van-der-waals ICL2 P 129 34x54 G.HN R 52 G.HN.52
Polar ICL2 F 132 34x57 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 F 132 34x57 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 F 132 34x57 G.hns1 R 55 G.hns1.02
Hydrophobic TM3 I 122 3x54 G.H5 M 379 G.H5.24
Hydrophobic TM5 Q 219 5x35 G.H5 F 361 G.H5.06
Van-der-waals TM5 Q 219 5x35 G.H5 F 361 G.H5.06
Hydrophobic TM6 V 317 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 V 317 6x33 G.H5 M 379 G.H5.24
Polar TM3 R 118 3x50 G.H5 Q 381 G.H5.26
Hydrophobic ICL2 P 129 34x54 G.HN R 51 G.HN.51
Van-der-waals ICL2 P 129 34x54 G.HN R 51 G.HN.51
Ionic TM4 K 135 4x40 G.HN D 44 G.HN.44
Polar TM4 K 135 4x40 G.HN D 44 G.HN.44
Van-der-waals TM4 K 135 4x40 G.HN D 44 G.HN.44
Polar ICL2 K 126 34x51 G.S3 P 222 G.S3.02
Hydrophobic ICL2 K 126 34x51 G.S3 P 222 G.S3.02
Van-der-waals ICL2 K 126 34x51 G.S3 P 222 G.S3.02
Hydrophobic TM3 I 122 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 I 122 3x54 G.H5 L 375 G.H5.20
Hydrophobic ICL2 P 125 34x50 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 P 125 34x50 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 K 126 34x51 G.HN R 52 G.HN.52
Van-der-waals ICL2 K 126 34x51 G.HN R 52 G.HN.52
Hydrophobic ICL2 P 129 34x54 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 P 129 34x54 G.hns1 R 55 G.hns1.02
Aromatic TM5 Y 215 5x31 G.H5 F 361 G.H5.06
Hydrophobic TM5 Y 215 5x31 G.H5 F 361 G.H5.06
Van-der-waals TM5 Y 215 5x31 G.H5 F 361 G.H5.06
Polar ICL2 K 126 34x51 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 K 126 34x51 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 K 126 34x51 G.hns1 R 56 G.hns1.03
Hydrophobic TM5 Y 215 5x31 G.H5 A 365 G.H5.10
Van-der-waals TM5 Y 215 5x31 G.H5 A 365 G.H5.10
Polar ICL2 K 126 34x51 G.HN A 53 G.HN.53
Hydrophobic ICL2 K 126 34x51 G.HN A 53 G.HN.53
Van-der-waals ICL2 K 126 34x51 G.HN A 53 G.HN.53
Polar ICL2 F 128 34x53 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 F 128 34x53 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 F 128 34x53 G.hns1 R 55 G.hns1.02
Hydrophobic TM5 Y 215 5x31 G.H5 V 362 G.H5.07
Hydrophobic ICL2 K 126 34x51 G.S1 L 57 G.S1.01
Van-der-waals ICL2 K 126 34x51 G.S1 L 57 G.S1.01
Hydrophobic TM5 R 218 5x34 G.H5 F 361 G.H5.06
Van-der-waals TM5 R 218 5x34 G.H5 F 361 G.H5.06
Polar ICL2 P 125 34x50 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 P 125 34x50 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 P 125 34x50 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 K 126 34x51 G.hns1 R 55 G.hns1.02
Ionic TM6 E 313 6x29 G.H5 K 376 G.H5.21
Polar TM6 E 313 6x29 G.H5 K 376 G.H5.21
Hydrophobic TM6 E 313 6x29 G.H5 K 376 G.H5.21
Van-der-waals TM6 E 313 6x29 G.H5 K 376 G.H5.21
Hydrophobic ECL2 L 212 - G.H5 Q 372 G.H5.17
Van-der-waals ECL2 L 212 - G.H5 Q 372 G.H5.17
Hydrophobic TM2 N 56 2x40 G.H5 Q 381 G.H5.26
Van-der-waals TM2 N 56 2x40 G.H5 Q 381 G.H5.26
Polar ICL2 Q 130 34x55 G.HN R 52 G.HN.52
Hydrophobic ICL2 Q 130 34x55 G.HN R 52 G.HN.52
Van-der-waals ICL2 Q 130 34x55 G.HN R 52 G.HN.52