CHEMBL3818124


SMILES O=C1NCN(c2ccccc2)C12CCN(CCCCc1nc3cc(Cl)ccc3s1)CC2
InChIKey JEYKHDMZDCZJFI-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 6
Molecular weight (Da) 454.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 5.8 5.8 5.8 ChEMBL
H1 HRH1 Human Histamine A pKi 6.56 6.57 6.58 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 7.44 7.44 7.44 ChEMBL
D4 DRD4 Human Dopamine A pKi 5.8 5.81 5.82 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 6.21 6.21 6.21 ChEMBL
5-HT1A 5HT1A Human 5-Hydroxytryptamine A pKi 6.99 6.99 6.99 ChEMBL
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 5.8 5.88 5.95 ChEMBL
D3 DRD3 Human Dopamine A pKi 6.3 6.3 6.3 ChEMBL
D2 DRD2 Human Dopamine A pKi 7.74 7.75 7.75 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database