GproteinDb

GproteinDb (G protein database) offers:

  • Reference data (see Data box)
  • Analysis tools (browse menu)
  • Visualization (e.g., snakeplots)
  • Experiment design (Coupling determinant mutations)
  • Data deposition (for G protein couplings and interface mutations)


G proteins are the main mediators of GPCR signaling1. Their activation is followed by recruitment of arrestins that arrest (stop) signaling or scaffold additional signaling proteins. There are 16 human G protein subtypes from 4 families that can be involved in biased signaling.

Data

  • Sequences
  • 16 Human G proteins
  • 317 Species orthologs
  • Couplings
  • 3,052 G protein couplings
  • Structures
  • 1,128 G proteins
  • 1,007 G protein complexes
  • 539 Generic residues
  • Structure models
  • 5,594 G protein complexes
  • 376 Refined complexes
  • Structure interactions
  • 379,219 G protein interface
  • Mutations
  • 54 Interface mutations

Overview


Latest release

March 20, 2025
  • Complete redesign of the Drug section
  • New improved and curated Drug data (Nature Reviews Drug Discovery, 2025)
  • Dedicated sections for agents/drugs, indications and drug targets
  • Overview of the drugged GPCRome
  • New structures
  • Minor bug and performance fixes

All releases

Related resources

GPCRdb, GproteinDb, ArrestinDb and Biased Signaling Atlas cover related aspects of signal transduction while serving dedicated research communities and use cases.

Publications

GproteinDb in 2024: New G protein-GPCR couplings, AlphaFold2-Multimer models and interface interactions.
Pándy-Szekeres G, Taracena Herrera LP, Caroli J, Kermani AA, Kulkarni Y, Keserű GM, Gloriam DE Nucleic Acids Research, 2023

The G protein database, GproteinDb.
Pándy-Szekeres G, Esguerra M, Hauser AS, Caroli J, Munk C, Pilger S, Keserű GM, Kooistra AJ, Gloriam DE
Nucleic Acids Research, 2021