GproteinDb contains reference data, interactive visualization and experiment design tools for G proteins. GproteinDb curates sequence alignments, structures and mutations from literature. Interactive diagrams visualise G protein residues (e.g. snakeplot) and interactions with receptors.

GproteinDb is developed by the David Gloriam group, integrates data from the research community and maintains an active collaboration with the Guide To Pharmacology (IUPHAR), GPCRmd, ERNEST and DrGPCR. If you use the GproteinDb, please remember to cite us.

GproteinDb statistics

  • 16 Human G proteins
  • 317 Species orthologs
  • Experimental structures
  • 399 G proteins
  • 257 GPCR-G protein complexes
  • Structure models
  • 3,075 GPCR-G protein complexes
  • 225 Refined complex structures
  • Structure interactions
  • 7,557 GPCR-G protein interface
  • Couplings
  • 4,027 GPCR-G protein coupling
  • Mutations
  • 54 Interface mutations
GPCRdb, GproteinDb, and ArrestinDb had 53,283 different users since this date last year and 5,456 users in the last 30 days (Google Analytics).

Latest release

April 30, 2022
  • Updated GPCR and G protein structures.
  • Updated GPCR ligand and bioactivity data to ChEMBL v30.
  • Updated GPCR homology and refined structure models.
  • Minor bug and performance fixes.