GproteinDb

GproteinDb (G protein database) offers:

  • Reference data (see Data box)
  • Analysis tools (browse menu)
  • Visualization (e.g., snakeplots)
  • Experiment design (Coupling determinant mutations)
  • Data deposition (for G protein couplings and interface mutations)


G proteins are the main mediators of GPCR signaling1. Their activation is followed by recruitment of arrestins that arrest (stop) signaling or scaffold additional signaling proteins. There are 16 human G protein subtypes from 4 families that can be involved in biased signaling.

Data

  • Sequences
  • 16 Human G proteins
  • 317 Species orthologs
  • Couplings
  • 3,730 G protein couplings
  • Structures
  • 645 G proteins
  • 502 G protein complexes
  • 539 Generic residues
  • Structure models
  • 3,058 G protein complexes
  • 394 Refined complexes
  • Structure interactions
  • 14,417 G protein interface
  • Mutations
  • 54 Interface mutations

Latest release

June 19, 2023
  • Drugs, targets and indications page layout updated
  • 54 new structures
  • All PDB files updated to their most recent version
  • G protein chimera mapping improved
  • Improved GPCR - G protein interface interactions
  • Interaction bug fixes
  • Hydrogen atoms removed from AlphaFold models
  • Minor bug and performance fixes

All releases

Related resources

GPCRdb, GproteinDb, ArrestinDb and Biased Signaling Atlas cover related aspects of signal transduction while serving dedicated research communities and use cases.

Publications

The G protein database, GproteinDb.
Pandy-Szekeres G, Esguerra M, Hauser AS, Caroli J, Munk C, Pilger S, Keseru GM, Kooistra AJ, Gloriam DE
Nucleic acids research, 2022, 50:D518-D525