Data
- Sequences
- 16 Human G proteins
- 317 Species orthologs
- Couplings
- 3,730 G protein couplings
- Structures
- 590 G proteins
- 460 G protein complexes
- 539 Generic residues
- Structure models
- 3,058 G protein complexes
- 322 Refined complexes
- Structure interactions
- 13,281 G protein interface
- Mutations
- 54 Interface mutations
Latest release
March 9, 2023- 195 new structures added (up until December 2022)
- New automated structure segment annotation based on DSSP and custom rules
- New interaction calculation process using RDKit for higher precision and accuracy
- Van der Waals interactions added
- Class C activation state reverted to author based annotation instead of degree active calculation
- New API calls for ligand data
- Hydrogen atoms removed from AlphaFold models
- GPCR - G protein interface interactions figures are now downloadable
- Structure annotation fixes
- Minor bug and performance fixes
All releases
Related resources
GPCRdb, GproteinDb, ArrestinDb and Biased Signaling Atlas cover related aspects of signal transduction while serving dedicated research communities and use cases. Together, they have served 6,768/58,928 users in the last month/year (Google Analytics)Publications
The G protein database, GproteinDb.Pandy-Szekeres G, Esguerra M, Hauser AS, Caroli J, Munk C, Pilger S, Keseru GM, Kooistra AJ, Gloriam DE
Nucleic acids research, 2022, 50:D518-D525