Adapted from Pándy-Szekeres et al., Nucleic Acids Research, 2023
New G protein couplings
Unified coupling atlas and G protein selectivity profiles.
GPCR - G protein structure interface
Structure based coupling interface interactions for structures and models.
Structure models
New GPCR-G protein structure models with AlphaFold2-Multimer.
Sequence alignments
Alignments with generic residue numbers and residue plots.
Structures
G protein structure statistics and browser with unique annotation.
GproteinDb
GproteinDb (G protein database) offers:
- Reference data (see Data box)
- Analysis tools (browse menu)
- Visualization (e.g., snakeplots)
- Experiment design (Coupling determinant mutations)
- Data deposition (for G protein couplings and interface mutations)
G proteins are the main mediators of GPCR signaling1.
Their activation is followed by recruitment of arrestins that arrest (stop) signaling or scaffold additional signaling proteins.
There are 16 human G protein subtypes from 4 families that can be involved in biased signaling.
Data
- Sequences
- 16 Human G proteins
- 317 Species orthologs
- 539 Generic residues
- Couplings
- 2,975 G protein couplings
- Structures
- 1,641 G proteins
- 1,551 G protein complexes
- Structure models
- 5,546 GPCR complexes
- 402 Refined complexes
- Structure interactions
- 472,915 G protein interface
- Mutations
- 54 Interface mutations
Overview
Latest release
Sept. 22, 2026- Structures page
- Adds all PDB structures released by July 15th, 2026
- Structure annotation adding auxiliary small molecules & ligand modality
- New, fast and user-friendly interface
- Structure coverage page
- New visualizations
- Structure models (ligand complexes) page
- Drug-GPCR models (from Boltz2)
- Peptide ligand-GPCR models (from AlphaFold)
- Ligands
- Ligand variants and groups
- Persistent ligand identifiers
- Peptide hormone analog bioactivities page
- New ligand bioactivities from literature
- Ligand interactions page
- New interface
- Data mapper page
- Data pasting and editing online
- Other
- Gene names with NCBI Entrez links
- Vomeronasal pheromone receptors added
- Sequence alignments page
- GPCR segment selection visual update
- Receptor page
- Snake plots, vertical helix alignment
- GPCR Classification
- Arrestin-GPCR complex models (from AlphaFold-multimer)
- Phosphorylation site resource
All releases
Related resources
GPCRdb, GproteinDb, ArrestinDb and Biased Signaling Atlas cover related aspects of signal transduction while serving dedicated research communities and use cases.Publications
GproteinDb in 2024: New G protein-GPCR couplings, AlphaFold2-Multimer models and interface interactions.
Pándy-Szekeres G, Taracena Herrera LP, Caroli J, Kermani AA, Kulkarni Y, Keserű GM, Gloriam DE
Nucleic Acids Research, 2023
The G protein database, GproteinDb.
Pándy-Szekeres G, Esguerra M, Hauser AS, Caroli J, Munk C, Pilger S, Keserű GM, Kooistra AJ, Gloriam DE
Nucleic Acids Research, 2021
