Data
- Sequences
- 16 Human G proteins
- 317 Species orthologs
- Couplings
- 3,730 G protein couplings
- Structures
- 498 G proteins
- 298 G protein complexes
- 539 Generic residues
- Structure models
- 3,058 G protein complexes
- 245 Refined complexes
- Structure interactions
- 8,685 G protein interface
- Mutations
- 54 Interface mutations
Latest release
Nov. 3, 2022- New refined GPCR structures using AlphaFold
- New full-length and state-specific AlphaFold models for all human GPCRs
- New functionality for searching ligands by name, database identifier, or SMILES/InChIKey
- Updated the ligand and bioactivity pages
- Updated GPCR ligands and bioactivities with data from Guide to Pharmacology and PDSP Ki
- Updated the new Endogenous ligands browser
- Minor bug and performance fixes
All releases
Related resources
GPCRdb, GproteinDb, ArrestinDb and Biased Signaling Atlas cover related aspects of signal transduction while serving dedicated research communities and use cases. Together, they have served 4,650/50,422 users in the last month/year (Google Analytics)Publications
The G protein database, GproteinDb.Pandy-Szekeres G, Esguerra M, Hauser AS, Caroli J, Munk C, Pilger S, Keseru GM, Kooistra AJ, Gloriam DE
Nucleic acids research, 2022, 50:D518-D525