GproteinDb

Align seqs Superposition

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G PROTEIN										STRUCTURE				RECEPTOR					OTHER PROTEINS			STRUCTURE LIGAND			PHYSIOLOGICAL LIGAND		REFERENCE
	Fam.	α	Species	Note	% of Seq	β	Species	γ	Species	Method	PDB	Refined structure	Resolution	UniProt	IUPHAR	Receptor family	Class	Species	Receptor fusion	Antibodies	Other	Name	Type	Function	Name	Type	Authors	Reference	PDB Date
	No matches found	No matches found	No matches found			No matches found	No matches found	No matches found	No matches found	No matches found	No matches found	No matches found		No matches found	No matches found	No matches found	No matches found	No matches found					No matches found	No matches found	No matches found	No matches found	No matches found	No matches found

									STRUCTURE				RECEPTOR					OTHER PROTEINS			STRUCTURE LIGAND			PHYSIOLOGICAL LIGAND		REFERENCE
Fam.	α	Species	Note	% of Seq	β	Species	γ	Species	Method	PDB	Refined structure	Resolution	UniProt	IUPHAR	Receptor family	Class	Species	Receptor fusion	Antibodies	Other	Name	Type	Function	Name	Type	Authors	Reference	PDB Date
No matches found	No matches found	No matches found			No matches found	No matches found	No matches found	No matches found	No matches found	No matches found	No matches found		No matches found	No matches found	No matches found	No matches found	No matches found					No matches found	No matches found	No matches found	No matches found	No matches found	No matches found
G12/13	α13	Human	G13-Gi2 chimera	56	β1	Human	γ2	Human	Cryo-EM	9IZH	-	3.0	LPAR1	LPA₁	Lysophospholipid (LPA)	A (Rhodopsin)	Human	BRIL	scFv16	LgBiT	lysophosphatidic acid pubchem	small-molecule	Agonist	1-O-Oleoyl-D-glycerol 3-phosphoric acid	small-molecule	Suzuki S, Tanaka K, Kamegawa A, Nishikawa K, Suzuki H, Oshima A, Fujiyoshi Y	10.1016/J.JSB.2024.108164	2025-01-01	56213
G12/13	α13	Human	-	57	β1	Human	γ2	Human	Cryo-EM	9IY8	9IY8_refined	3.0	GPR55	GPR55	GPR18, GPR55 and GPR119	A (Rhodopsin)	Human	-	scFv16	-	Apo (no ligand)	none	Apo (no ligand)	2-arachidonoylglycerolphosphoinositol, lysophosphatidylinositol, 2-arachidonoylglycerol, N-palmitoylethanolamine, anandamide	small-molecule	Chang H, Li X, Shen L, Ge X, Hao S, Wu L, Liu S, Liu J, Cherezov V, Hua T	10.1038/S41422-024-01046-8	2025-01-01	56213
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	8XML	-	2.6	CCR8	CCR8	Chemokine	A (Rhodopsin)	Human	BRIL	scFv16	-	Apo (no ligand)	none	Apo (no ligand)	CCL8, CCL1	peptide	-	-	2025-01-01	56200
Gi/o	αi1	Human	-	61	β1	Human	γ2	Mouse	Cryo-EM	9IZF	-	3.1	LPAR1	LPA₁	Lysophospholipid (LPA)	A (Rhodopsin)	Human	BRIL	scFv16	LgBiT	lysophosphatidic acid pubchem	small-molecule	Agonist	1-O-Oleoyl-D-glycerol 3-phosphoric acid	small-molecule	-	-	2025-01-01	56200
Gq/11	αq	Human	Gq-Gs chimera	57	β1	Human	γ2	Mouse	Cryo-EM	9IZG	-	3.0	LPAR1	LPA₁	Lysophospholipid (LPA)	A (Rhodopsin)	Human	BRIL	scFv16	LgBiT	lysophosphatidic acid pubchem	small-molecule	Agonist	1-O-Oleoyl-D-glycerol 3-phosphoric acid	small-molecule	-	-	2025-01-01	56208
Gi/o	αi1	Human	-	61	β1	Human	γ2	Human	Cryo-EM	8JEF	8JEF_refined	3.0	HCAR3	HCA₃	Hydroxycarboxylic acid	A (Rhodopsin)	Human	-	scFv16	-	3-hydroxyoctanoic acid pubchem gtoplig	small-molecule	Agonist	3-hydroxyoctanoic acid	small-molecule	Ye F, Pan X, Zhang Z, Xiang X, Li X, Zhang B, Ning P, Liu A, Wang Q, Gong K, Li J, Zhu L, Qian C, Chen G, Du Y	10.1016/J.CELREP.2024.114895	2024-12-18	56200
Gi/o	αi1	Human	-	64	β1	Human	γ2	Human	Cryo-EM	8YIC	8YIC_refined	3.5	S1PR1	S1P₁	Lysophospholipid (S1P)	A (Rhodopsin)	Human	T4-Lysozyme	-	-	SAR247799 pubchem gtoplig chembl_ligand	small-molecule	Agonist	dihydrosphingosine 1-phosphate, sphingosylphosphorylcholine, sphingosine 1-phosphate	small-molecule	-	-	2024-12-11	56200
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	9K1D	-	3.3	FFAR2	FFA2	Free fatty acid	A (Rhodopsin)	Human	-	-	-	butyric acid pubchem gtoplig chembl_ligand drugbank	small-molecule	Agonist	butyric acid, acetic acid, trans-2-methylcrotonic acid, propanoic acid	small-molecule	Ke Y, Huang Y, Yi C, Ma L, Chu X, Wu B, Zhao Q, Han S	10.1016/J.CELREP.2024.115024	2024-12-11	56200
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	9K1C	9K1C_refined	3.2	FFAR1	FFA1	Free fatty acid	A (Rhodopsin)	Human	-	-	-	docosahexaenoic acid pubchem gtoplig chembl_ligand drug_central drugbank pubchem	small-molecule	Agonist	myristic acid, oleic acid, docosahexaenoic acid, α-linolenic acid	small-molecule	Ke Y, Huang Y, Yi C, Ma L, Chu X, Wu B, Zhao Q, Han S	10.1016/J.CELREP.2024.115024	2024-12-11	56200
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	9AST	9AST_refined	3.1	XCR1	XCR1	Chemokine	A (Rhodopsin)	Human	-	scFv16	Non structural polyprotein	Lymphotactin	protein	Agonist	XCL1, XCL2	peptide	Zhang X, Schlimgen RR, Singh S, Tomani MP, Volkman BF, Zhang C	10.1073/PNAS.2405732121	2024-12-11	56200
Gq/11	αq	Human	Gq-Gs-Gi chimera	57	β1	Human	γ2	Human	Cryo-EM	9DQH	9DQH_refined	2.9	MRGRD	MRGPRD	A orphans	A (Rhodopsin)	Human	-	scFv16	-	2-[[1-[2-(4-chlorophenyl)-2-methylpropanoyl]piperidin-4-yl]amino]-5,6,7,8-tetrahydro-3H-quinazolin-4-one pubchem	small-molecule	Agonist	β-alanine	small-molecule	-	-	2024-12-11	56208
Gq/11	αq	Human	Gq-Gs-Gi chimera	57	β1	Human	γ2	Human	Cryo-EM	9DQJ	9DQJ_refined	2.9	MRGRD	MRGPRD	A orphans	A (Rhodopsin)	Human	-	scFv16	-	2-[[1-[1-(4-methoxyphenyl)cyclopropanecarbonyl]piperidin-4-yl]amino]-3H-quinazolin-4-one pubchem	small-molecule	Agonist	β-alanine	small-molecule	-	-	2024-12-11	56208
Gi/o	αi1	Human	-	64	β1	Human	γ2	Human	Cryo-EM	9IYB	-	2.8	PD2R2	DP₂	Prostanoid	A (Rhodopsin)	Human	-	scFv16	-	PGD2	lipid	Agonist	PGD₃, PGF_2α, PGI₂, PGJ₂, PGE₂, thromboxane A₂, PGD₂	small-molecule	-	-	2024-12-04	56200
Gi/o	αi1	Human	-	64	β1	Human	γ2	Human	Cryo-EM	8XXV	-	2.3	PD2R2	DP₂	Prostanoid	A (Rhodopsin)	Human	-	scFv16	-	[(2~{R})-1-hexadecanoyloxy-3-[oxidanyl-[(2~{S},3~{R},5~{R},6~{S})-2,3,4,5,6-pentakis(oxidanyl)cyclohexyl]oxy-phosphoryl]oxy-propan-2-yl] (~{Z})-octadec-9-enoate	lipid	PAM	PGD₃, PGF_2α, PGI₂, PGJ₂, PGE₂, thromboxane A₂, PGD₂	small-molecule	-	-	2024-12-04	56200
Gi/o	αi1	Human	-	64	β1	Human	γ2	Human	Cryo-EM	8XXU	-	2.5	PD2R2	DP₂	Prostanoid	A (Rhodopsin)	Human	-	scFv16	-	[(2~{R})-1-hexadecanoyloxy-3-[oxidanyl-[(2~{S},3~{R},5~{R},6~{S})-2,3,4,5,6-pentakis(oxidanyl)cyclohexyl]oxy-phosphoryl]oxy-propan-2-yl] (~{Z})-octadec-9-enoate	lipid	PAM	PGD₃, PGF_2α, PGI₂, PGJ₂, PGE₂, thromboxane A₂, PGD₂	small-molecule	-	-	2024-12-04	56200
Gs	αs	Human	-	60	β1	Human	γ2	Human	Cryo-EM	8TYW	8TYW_refined	3.4	GPR6	GPR6	A orphans	A (Rhodopsin)	Human	-	Nanobody-35	-	Apo (no ligand)	none	Apo (no ligand)	sphingosine 1-phosphate	small-molecule	Barekatain M, Johansson LC, Lam JH, Chang H, Sadybekov AV, Han GW, Russo J, Bliesath J, Brice NL, Carlton MBL, Saikatendu KS, Sun H, Murphy ST, Monenschein H, Schiffer HH, Popov P, Lutomski CA, Robinson CV, Liu ZJ, Hua T, Katritch V, Cherezov V	10.1126/SCISIGNAL.ADO8741	2024-12-04	56198
Gi/o	αi1	Bovine	-	63	β1	Rat	γ2	Human	Cryo-EM	9J5V	-	2.9	LPAR1	LPA₁	Lysophospholipid (LPA)	A (Rhodopsin)	Human	-	scFv16	LgBiT	CpY pubchem gtoplig	small-molecule	Agonist	1-O-Oleoyl-D-glycerol 3-phosphoric acid	small-molecule	-	-	2024-11-27	56241
Gi/o	αi2	Human	-	63	β1	Human	γ2	Human	Cryo-EM	8Y45	8Y45_refined	3.5	OPRD	δ	Opioid	A (Rhodopsin)	Human	-	scFv16	-	ADL5859 pubchem gtoplig chembl_ligand	small-molecule	Agonist	dynorphin B, dynorphin A-(1-13), dynorphin A-(1-8), β-endorphin, α-neoendorphin, [Met]enkephalin, dynorphin A, [Leu]enkephalin, endomorphin-1	peptide	-	-	2024-11-27	56201
Gi/o	αgust	Human	-	61	β1	Human	γ2	Human	Cryo-EM	8RQL	-	3.0	T2R14	TAS2R14	Taste 2	T2 (Taste 2)	Human	-	scFv16	-	flufenamic acid pubchem gtoplig chembl_ligand drugbank drug_central	small-molecule	Agonist	-	-	Peri L, Matzov D, Huxley DR, Rainish A, Fierro F, Sapir L, Pfeiffer T, Waterloo L, Hubner H, Peleg Y, Gmeiner P, McCormick PJ, Weikert D, Niv MY, Shalev-Benami M	10.1038/S41467-024-54157-6	2024-11-27	56205
Gs	αs	Human	Gs-Gi chimera	62	β1	Human	γ2	Human	Cryo-EM	9IVG	9IVG_refined	3.0	GLP1R	GLP-1	Glucagon	B1 (Secretin)	Human	-	Nanobody-35	-	CHEMBL410972 chembl_ligand pubchem pubchem	protein	Agonist	glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37)	peptide	Li J, Li G, Mai Y, Liu X, Yang D, Zhou Q, Wang MW	10.1016/J.APSB.2024.09.002	2024-11-27	56198
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	8X3L	8X3L_refined	3.1	CNR2	CB₂	Cannabinoid	A (Rhodopsin)	Human	-	scFv16	-	CHEMBL5422946 chembl_ligand pubchem	small-molecule	Agonist	2-arachidonoylglycerol, anandamide	small-molecule	Yang X, Zhou P, Shen S, Hu Q, Tian C, Xia A, Wang Y, Yang Z, Nan J, Zhou Y, Chen S, Tian X, Wu C, Lin G, Zhang L, Wang K, Zheng T, Zou J, Yan W, Shao Z, Yang S	10.1073/PNAS.2401091121	2024-11-20	56200
Gi/o	αi1	Human	-	94	β1	Bovine	γT1	Bovine	Cryo-EM	8P13	-	5.2	OPSD	Rhodopsin	Opsins	A (Rhodopsin)	Bovine	-	Fab heavy chain Fab light chain scFv16	-	Apo (no ligand)	none	Apo (no ligand)	-	-	-	-	2024-11-20	56200
Gi/o	αi1	Human	-	59	β1	Bovine	γT1	Bovine	Cryo-EM	8P12	-	3.2	OPSD	Rhodopsin	Opsins	A (Rhodopsin)	Bovine	-	Fab heavy chain Fab light chain	-	Apo (no ligand)	none	Apo (no ligand)	-	-	-	-	2024-11-20	56200
Gi/o	αi1	Human	-	96	β1	Bovine	γT1	Bovine	Cryo-EM	8P15	-	5.9	OPSD	Rhodopsin	Opsins	A (Rhodopsin)	Bovine	-	Fab heavy chain Fab light chain scFv16	-	Apo (no ligand)	none	Apo (no ligand)	-	-	-	-	2024-11-20	56200
Gi/o	αi1	Human	-	61	β1	Human	γ2	Human	Cryo-EM	8JEI	-	2.7	HCAR3	HCA₃	Hydroxycarboxylic acid	A (Rhodopsin)	Human	-	scFv16	-	4-(n-propyl)amino-3-nitrobenzoic acid pubchem gtoplig chembl_ligand	small-molecule	Agonist	3-hydroxyoctanoic acid	small-molecule	Ye F, Pan X, Zhang Z, Xiang X, Li X, Zhang B, Ning P, Liu A, Wang Q, Gong K, Li J, Zhu L, Qian C, Chen G, Du Y	10.1016/J.CELREP.2024.114895	2024-11-20	56200
G12/13	α13	Human	-	56	β1	Human	γ2	Human	Cryo-EM	8ZX5	-	3.0	GPR55	GPR55	GPR18, GPR55 and GPR119	A (Rhodopsin)	Human	-	-	-	AM251 pubchem gtoplig chembl_ligand	small-molecule	Agonist	2-arachidonoylglycerolphosphoinositol, lysophosphatidylinositol, 2-arachidonoylglycerol, N-palmitoylethanolamine, anandamide	small-molecule	-	-	2024-11-13	56213
G12/13	α13	Human	-	56	β1	Human	γ2	Human	Cryo-EM	8ZX4	-	2.9	GPR55	GPR55	GPR18, GPR55 and GPR119	A (Rhodopsin)	Human	-	-	-	LPI	small-molecule	Agonist	2-arachidonoylglycerolphosphoinositol, lysophosphatidylinositol, 2-arachidonoylglycerol, N-palmitoylethanolamine, anandamide	small-molecule	-	-	2024-11-13	56213
Gi/o	αi1	Human	-	63	β1	Human	γ2	Human	Cryo-EM	8WWI	8WWI_refined	3.4	MCHR1	MCH₁	Melanin-concentrating hormone	A (Rhodopsin)	Human	-	scFv16	-	Apo (no ligand)	none	Apo (no ligand)	melanin-concentrating hormone	peptide	-	-	2024-11-13	56200
Gi/o	αi1	Human	-	63	β1	Human	γ2	Human	Cryo-EM	8WWM	8WWM_refined	2.8	MCHR1	MCH₁	Melanin-concentrating hormone	A (Rhodopsin)	Human	-	scFv16	-	Melanin-concentrating hormone	peptide	Agonist	melanin-concentrating hormone	peptide	Ye X, Liu G, Li X, He B, Tao Y, Guan J, Mu Y, Liu H, Gong W	10.1038/S41421-024-00754-0	2024-11-13	56200
Gi/o	αi1	Human	-	61	β1	Human	γ2	Human	Cryo-EM	8XYD	8XYD_refined	2.9	PTAFR	PAF	Platelet-activating factor	A (Rhodopsin)	Human	-	scFv16	-	PAF pubchem gtoplig chembl_ligand drugbank gtoplig	small-molecule	Agonist	PAF	small-molecule	Fan W, Xu Y, He X, Luo P, Zhu J, Li J, Wang R, Yuan Q, Wu K, Hu W, Zhao Y, Xu S, Cheng X, Wang Y, Xu HE, Zhuang Y	10.1016/J.CELREP.2024.114422	2024-11-13	56200
Gi/o	αi1	Human	-	63	β1	Human	γ2	Human	Cryo-EM	8WWK	8WWK_refined	2.6	MCHR1	MCH₁	Melanin-concentrating hormone	A (Rhodopsin)	Human	-	scFv16	-	Melanin-concentrating hormone	peptide	Agonist	melanin-concentrating hormone	peptide	Ye X, Liu G, Li X, He B, Tao Y, Guan J, Mu Y, Liu H, Gong W	10.1038/S41421-024-00754-0	2024-11-13	56200
Gi/o	αi1	Human	-	63	β1	Human	γ2	Human	Cryo-EM	8WWN	8WWN_refined	2.7	MCHR1	MCH₁	Melanin-concentrating hormone	A (Rhodopsin)	Human	-	scFv16	-	Melanin-concentrating hormone	peptide	Agonist	melanin-concentrating hormone	peptide	Ye X, Liu G, Li X, He B, Tao Y, Guan J, Mu Y, Liu H, Gong W	10.1038/S41421-024-00754-0	2024-11-13	56200
Gi/o	αi1	Human	-	63	β1	Human	γ2	Human	Cryo-EM	8WWJ	-	3.0	MCHR1	MCH₁	Melanin-concentrating hormone	A (Rhodopsin)	Human	-	scFv16	-	Apo (no ligand)	none	Apo (no ligand)	melanin-concentrating hormone	peptide	-	-	2024-11-13	56200
Gi/o	αi1	Human	-	63	β1	Human	γ2	Human	Cryo-EM	8WWL	8WWL_refined	2.8	MCHR1	MCH₁	Melanin-concentrating hormone	A (Rhodopsin)	Human	-	scFv16	-	Melanin-concentrating hormone	peptide	Agonist	melanin-concentrating hormone	peptide	Ye X, Liu G, Li X, He B, Tao Y, Guan J, Mu Y, Liu H, Gong W	10.1038/S41421-024-00754-0	2024-11-13	56200
Gi/o	αi1	Human	-	63	β1	Human	γ2	Human	Cryo-EM	8WWH	8WWH_refined	2.8	MCHR1	MCH₁	Melanin-concentrating hormone	A (Rhodopsin)	Human	-	scFv16	-	Apo (no ligand)	none	Apo (no ligand)	melanin-concentrating hormone	peptide	-	-	2024-11-13	56200
Gs	αs	Human	Gs-Gi chimera	62	β1	Human	γ2	Human	Cryo-EM	9IVM	-	3.2	GLP1R	GLP-1	Glucagon	B1 (Secretin)	Human	-	Nanobody-35	-	CHEMBL410972 chembl_ligand pubchem pubchem LSN3318839 pubchem gtoplig chembl_ligand	protein small-molecule	Agonist PAM	glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37)	peptide	-	-	2024-11-13	56198
Gi/o	αi1	Bovine	-	-	-	-	-	-	Cryo-EM	8YH3	-	3.4	-	-	-	-	-	-	-	Hemagglutinin Adenosine receptor A3 GFP chimera	-	-	-	-	-	Oshima HS, Ogawa A, Sano FK, Akasaka H, Kawakami T, Iwama A, Okamoto HH, Nagiri C, Wei FY, Shihoya W, Nureki O	39511145	2024-11-06	56241
Gi/o	αi1	Bovine	-	-	-	-	-	-	Cryo-EM	8YH5	-	3.7	-	-	-	-	-	-	-	-	-	-	-	-	-	Oshima HS, Ogawa A, Sano FK, Akasaka H, Kawakami T, Iwama A, Okamoto HH, Nagiri C, Wei FY, Shihoya W, Nureki O	39511145	2024-11-06	56241
Gi/o	αi1	Bovine	-	-	-	-	-	-	Cryo-EM	8YH6	-	3.6	-	-	-	-	-	-	-	-	-	-	-	-	-	Oshima HS, Ogawa A, Sano FK, Akasaka H, Kawakami T, Iwama A, Okamoto HH, Nagiri C, Wei FY, Shihoya W, Nureki O	39511145	2024-11-06	56241
Gi/o	αi1	Human	-	-	-	-	-	-	Cryo-EM	8YH0	-	2.9	-	-	-	-	-	-	-	HA tag Adenosine receptor A3 LgBiT eGFP chimera	-	-	-	-	-	Oshima HS, Ogawa A, Sano FK, Akasaka H, Kawakami T, Iwama A, Okamoto HH, Nagiri C, Wei FY, Shihoya W, Nureki O	39511145	2024-11-06	56200
Gi/o	αi1	Human	-	-	-	-	-	-	Cryo-EM	8YH2	-	3.3	-	-	-	-	-	-	-	Hemagglutinin Adenosine receptor A3 GFP chimera	-	-	-	-	-	Oshima HS, Ogawa A, Sano FK, Akasaka H, Kawakami T, Iwama A, Okamoto HH, Nagiri C, Wei FY, Shihoya W, Nureki O	39511145	2024-11-06	56200
Gq/11	αq	Human	Gq-Gs chimera	57	β1	Human	γ2	Human	Cryo-EM	8K4S	8K4S_refined	2.9	MRGX4	MRGPRX4	A orphans	A (Rhodopsin)	Human	BRIL	scFv16	GFP	DCA-3P pubchem	small-molecule	Agonist	-	-	Yang J, Zhao T, Fan J, Zou H, Lan G, Guo F, Shi Y, Ke H, Yu H, Yue Z, Wang X, Bai Y, Li S, Liu Y, Wang X, Chen Y, Li Y, Lei X	10.1016/J.CELL.2024.10.001	2024-11-06	56208
Gi/o	αi3	Human	-	63	β1	Human	γ2	Human	Cryo-EM	8WGB	-	3.7	GRM2	mGlu₂	Metabotropic glutamate	C (Glutamate)	Human	-	-	-	VU0155041 pubchem gtoplig chembl_ligand	small-molecule	Agonist	L-glutamic acid	small-molecule	Huang W, Jin N, Guo J, Shen C, Xu C, Xi K, Bonhomme L, Quast RB, Shen DD, Qin J, Liu YR, Song Y, Gao Y, Margeat E, Rondard P, Pin JP, Zhang Y, Liu J	10.1038/S41467-024-54744-7	2024-10-30	56202
Gi/o	αi1	Human	-	60	β1	Human	γ2	Human	Cryo-EM	8XGU	-	3.0	KISSR	kisspeptin	Kisspeptin	A (Rhodopsin)	Human	-	scFv16	-	ACY-DTY-HYP-ASN-THR-PHE-XZA-LEU-NMM-TRP-NH2	peptide	Agonist	kisspeptin-13, kisspeptin-54, kisspeptin-14, kisspeptin-52, kisspeptin-10	peptide	Wu Z, Chen G, Qiu C, Yan X, Xu L, Jiang S, Xu J, Han R, Shi T, Liu Y, Gao W, Wang Q, Li J, Ye F, Pan X, Zhang Z, Ning P, Zhang B, Chen J, Du Y	10.1126/SCIADV.ADN7771	2024-10-30	56200
Gi/o	αi1	Human	-	60	β1	Human	γT1	Bovine	Cryo-EM	9EPR	-	4.9	B1B1U5	Rhodopsin	Opsins	A (Rhodopsin)	Hasarius adansoni	-	-	-	Retinal (11-cis) pubchem	small-molecule	Agonist	-	-	Tejero O, Pamula F, Koyanagi M, Nagata T, Afanasyev P, Das I, Deupi X, Sheves M, Terakita A, Schertler GFX, Rodrigues MJ, Tsai CJ	10.1038/S41467-024-53208-2	2024-10-30	56200
Gq/11	αq	Human	-	64	β1	Human	γ2	Human	Cryo-EM	8XGS	-	3.0	KISSR	kisspeptin	Kisspeptin	A (Rhodopsin)	Human	-	scFv16	-	Kisspeptin-10 pubchem	peptide	Agonist	kisspeptin-13, kisspeptin-54, kisspeptin-14, kisspeptin-52, kisspeptin-10	peptide	Wu Z, Chen G, Qiu C, Yan X, Xu L, Jiang S, Xu J, Han R, Shi T, Liu Y, Gao W, Wang Q, Li J, Ye F, Pan X, Zhang Z, Ning P, Zhang B, Chen J, Du Y	10.1126/SCIADV.ADN7771	2024-10-30	56208
Gq/11	αq	Human	-	64	β1	Human	γ2	Human	Cryo-EM	8XGO	-	2.7	KISSR	kisspeptin	Kisspeptin	A (Rhodopsin)	Human	-	scFv16	-	TAK448	peptide	Agonist	kisspeptin-13, kisspeptin-54, kisspeptin-14, kisspeptin-52, kisspeptin-10	peptide	Wu Z, Chen G, Qiu C, Yan X, Xu L, Jiang S, Xu J, Han R, Shi T, Liu Y, Gao W, Wang Q, Li J, Ye F, Pan X, Zhang Z, Ning P, Zhang B, Chen J, Du Y	10.1126/SCIADV.ADN7771	2024-10-30	56208
Gs	αs	Human	-	60	β1	Human	γ2	Human	Cryo-EM	8VHF	8VHF_refined	3.5	GP119	GPR119	GPR18, GPR55 and GPR119	A (Rhodopsin)	Human	BRIL	Nanobody-35	-	MBX-2982 pubchem gtoplig chembl_ligand drugbank	small-molecule	Agonist	N-oleoylethanolamide, N-palmitoylethanolamine, SEA, anandamide	small-molecule	-	-	2024-10-30	56198
Gs	αs	Human	Mini-Gs	56	β1	Human	γ2	Human	Cryo-EM	8UXY	-	3.3	OR1F1	OR1F1	Odorant family 1	O2 (tetrapod specific odorant)	Human	-	Nanobody-35	-	l-Menthol pubchem	small-molecule	Agonist	-	-	de March CA, Ma N, Billesbolle CB, Tewari J, Llinas Del Torrent C, van der Velden WJC, Ojiro I, Takayama I, Faust B, Li L, Vaidehi N, Manglik A, Matsunami H	10.1038/S41586-024-08126-0	2024-10-30	56198
Gs	αs	Human	Mini-Gs	55	β1	Human	γ2	Human	Cryo-EM	8UYQ	-	3.5	OR4D5	OR4D5	Odorant family 4	O2 (tetrapod specific odorant)	Human	-	Nanobody-35	-	(2R)-2-methyl-1,3-thiazolidine pubchem	small-molecule	Agonist	-	-	de March CA, Ma N, Billesbolle CB, Tewari J, Llinas Del Torrent C, van der Velden WJC, Ojiro I, Takayama I, Faust B, Li L, Vaidehi N, Manglik A, Matsunami H	10.1038/S41586-024-08126-0	2024-10-30	56198
Gs	αs	Human	Mini-Gs	56	β1	Human	γ2	Human	Cryo-EM	8UXV	-	3.2	O51G2	OR51G2	Odorant family 51	O1 (fish-like odorant)	Human	-	Nanobody-35	-	Apo (no ligand)	none	Apo (no ligand)	-	-	de March CA, Ma N, Billesbolle CB, Tewari J, Llinas Del Torrent C, van der Velden WJC, Ojiro I, Takayama I, Faust B, Li L, Vaidehi N, Manglik A, Matsunami H	10.1038/S41586-024-08126-0	2024-10-30	56198
Gs	αs	Human	Mini-Gs	55	β1	Human	γ2	Human	Cryo-EM	8UY0	-	3.2	OR2T2	OR2T2	Odorant family 2	O2 (tetrapod specific odorant)	Human	-	Nanobody-35	-	(5S)-2-methyl-5-(prop-1-en-2-yl)cyclohex-2-en-1-one pubchem	small-molecule	Agonist	-	-	de March CA, Ma N, Billesbolle CB, Tewari J, Llinas Del Torrent C, van der Velden WJC, Ojiro I, Takayama I, Faust B, Li L, Vaidehi N, Manglik A, Matsunami H	10.1038/S41586-024-08126-0	2024-10-30	56198
Gi/o	αi1	Human	-	65	β1	Human	γ2	Human	Cryo-EM	9EPQ	-	4.2	B1B1U5	Rhodopsin	Opsins	A (Rhodopsin)	Hasarius adansoni	-	-	-	11,20-Ethanoretinal pubchem	small-molecule	Agonist	-	-	-	-	2024-10-23	56200
Gi/o	αi1	Human	-	63	β1	Human	γ2	Human	Cryo-EM	9EPP	-	4.1	B1B1U5	Rhodopsin	Opsins	A (Rhodopsin)	Hasarius adansoni	-	-	-	11,20-Ethanoretinal pubchem	small-molecule	Agonist	-	-	-	-	2024-10-23	56200
Gi/o	αo	Human	Mini-Go	61	β1	Human	γ2	Human	Cryo-EM	8YN7	-	2.8	HRH3	H₃	Histamine	A (Rhodopsin)	Human	-	scFv16	-	[(2R)-3-[(E)-hexadec-9-enoyl]oxy-2-octadecanoyloxypropyl] 2-(trimethylazaniumyl)ethyl phosphate pubchem	lipid	Agonist	histamine	small-molecule	-	-	2024-10-16	56206
Gi/o	αo	Human	Mini-Go	61	β1	Human	γ2	Human	Cryo-EM	8YN8	-	2.8	HRH3	H₃	Histamine	A (Rhodopsin)	Human	-	scFv16	-	proxyfan pubchem gtoplig chembl_ligand	small-molecule	Agonist	histamine	small-molecule	-	-	2024-10-16	56206
Gq/11	αq	Human	Mini-Gq	57	β1	Rat	γ2	Bovine	Cryo-EM	9JR3	-	2.8	PTH1R	PTH1	Parathyroid hormone	B1 (Secretin)	Human	-	scFv16	-	Parathyroid hormone pubchem	peptide	Agonist	PTH, PTHrP, TIP39, PTHrP-(1-36)	peptide	-	-	2024-10-16	56208
Gq/11	αq	Human	Mini-Gq	57	β1	Rat	γ2	Bovine	Cryo-EM	9JR2	-	2.8	PTH1R	PTH1	Parathyroid hormone	B1 (Secretin)	Human	-	scFv16	-	Parathyroid hormone pubchem	peptide	Agonist	PTH, PTHrP, TIP39, PTHrP-(1-36)	peptide	-	-	2024-10-16	56208
Gs	αs	Human	-	60	β1	Human	γ2	Human	Cryo-EM	9JKQ	9JKQ_refined	2.7	TAAR1	TA₁	Trace amine	A (Rhodopsin)	Human	BRIL	Nanobody-35	-	METHAMPHETAMINE chembl_ligand pubchem	small-molecule	Agonist	tyramine, (+)-Octopamine, octopamine, β-phenylethylamine, CHEMBL1160703, 3-iodothyronamine, dopamine	small-molecule	Lin Y, Wang J, Shi F, Yang L, Wu S, Qiao A, Ye S	10.1021/ACS.JMEDCHEM.4C01961	2024-10-16	56198
Gi/o	αi1	Human	-	63	β1	Human	γ2	Human	Cryo-EM	8YN9	-	2.3	HRH4	H₄	Histamine	A (Rhodopsin)	Human	-	scFv16	-	histamine pubchem gtoplig chembl_ligand drug_central drugbank gtoplig pubchem	small-molecule	Agonist	histamine, CCL16	small-molecule	Zhang X, Liu G, Zhong YN, Zhang R, Yang CC, Niu C, Pu X, Sun J, Zhang T, Yang L, Zhang C, Li X, Shen X, Xiao P, Sun JP, Gong W	10.1038/S41467-024-52585-Y	2024-10-09	56200
Gi/o	αi1	Human	-	63	β1	Human	γ2	Human	Cryo-EM	8YN6	-	2.8	HRH3	H₃	Histamine	A (Rhodopsin)	Human	-	scFv16	-	imetit pubchem gtoplig chembl_ligand pubchem	small-molecule	Agonist	histamine	small-molecule	Zhang X, Liu G, Zhong YN, Zhang R, Yang CC, Niu C, Pu X, Sun J, Zhang T, Yang L, Zhang C, Li X, Shen X, Xiao P, Sun JP, Gong W	10.1038/S41467-024-52585-Y	2024-10-09	56200
Gi/o	αi1	Human	-	63	β1	Human	γ2	Human	Cryo-EM	8YNA	-	2.6	HRH4	H₄	Histamine	A (Rhodopsin)	Human	-	scFv16	-	immepip pubchem gtoplig chembl_ligand	small-molecule	Agonist	histamine, CCL16	small-molecule	-	-	2024-10-09	56200
Gi/o	αi1	Human	-	63	β1	Human	γ2	Human	Cryo-EM	8YN5	-	2.7	HRH3	H₃	Histamine	A (Rhodopsin)	Human	-	scFv16	-	histamine pubchem gtoplig chembl_ligand drug_central drugbank gtoplig pubchem	small-molecule	Agonist	histamine	small-molecule	Zhang X, Liu G, Zhong YN, Zhang R, Yang CC, Niu C, Pu X, Sun J, Zhang T, Yang L, Zhang C, Li X, Shen X, Xiao P, Sun JP, Gong W	10.1038/S41467-024-52585-Y	2024-10-09	56200
Gq/11	αq	Human	Mini-Gq	64	β1	Human	γ2	Human	Cryo-EM	8YN4	-	3.0	HRH2	H₂	Histamine	A (Rhodopsin)	Human	-	scFv16	-	histamine pubchem gtoplig chembl_ligand drug_central drugbank gtoplig pubchem	small-molecule	Agonist	histamine	small-molecule	Zhang X, Liu G, Zhong YN, Zhang R, Yang CC, Niu C, Pu X, Sun J, Zhang T, Yang L, Zhang C, Li X, Shen X, Xiao P, Sun JP, Gong W	10.1038/S41467-024-52585-Y	2024-10-09	56208
Gq/11	αq	Human	Mini-Gq	64	β1	Human	γ2	Human	Cryo-EM	8YN2	-	2.7	HRH1	H₁	Histamine	A (Rhodopsin)	Human	-	scFv16	-	histamine pubchem gtoplig chembl_ligand drug_central drugbank gtoplig pubchem	small-molecule	Agonist	histamine	small-molecule	Zhang X, Liu G, Zhong YN, Zhang R, Yang CC, Niu C, Pu X, Sun J, Zhang T, Yang L, Zhang C, Li X, Shen X, Xiao P, Sun JP, Gong W	10.1038/S41467-024-52585-Y	2024-10-09	56208
Gs	αs	Human	Mini-Gq	60	β1	Human	γ2	Human	Cryo-EM	8YN3	-	2.6	HRH2	H₂	Histamine	A (Rhodopsin)	Human	-	Nanobody-35	-	histamine pubchem gtoplig chembl_ligand drug_central drugbank gtoplig pubchem	small-molecule	Agonist	histamine	small-molecule	Zhang X, Liu G, Zhong YN, Zhang R, Yang CC, Niu C, Pu X, Sun J, Zhang T, Yang L, Zhang C, Li X, Shen X, Xiao P, Sun JP, Gong W	10.1038/S41467-024-52585-Y	2024-10-09	56198
Gs	αs	Human	Mini-Gs	59	β1	Human	γ2	Human	Cryo-EM	9GYO	-	2.5	GPBAR	GPBA	Bile acid	A (Rhodopsin)	Human	BRIL	Nanobody-35	-	CHEMBL2331646 chembl_ligand pubchem	small-molecule	Agonist	lithocholic acid, deoxycholic acid, cholic acid, chenodeoxycholic acid	small-molecule	-	-	2024-10-09	56198
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	8XWP	8XWP_refined	3.2	EDNRB	ET_B	Endothelin	A (Rhodopsin)	Human	-	scFv16	-	ENDOTHELIN chembl_ligand pubchem	protein	Agonist	endothelin-2, endothelin-3, endothelin-1	peptide	Tani K, Maki-Yonekura S, Kanno R, Negami T, Hamaguchi T, Hall M, Mizoguchi A, Humbel BM, Terada T, Yonekura K, Doi T	10.1038/S42003-024-06905-Z	2024-10-02	56200
Gi/o	αi1	Human	-	64	β1	Human	γ2	Human	Cryo-EM	9IQT	9IQT_refined	2.9	HCAR2	HCA₂	Hydroxycarboxylic acid	A (Rhodopsin)	Human	-	scFv16	-	nicotinic acid pubchem gtoplig chembl_ligand drugbank drug_central gtoplig pubchem	small-molecule	Agonist	butyric acid, β-D-hydroxybutyric acid	small-molecule	Liu Y, Zhou Z, Guan F, Han Z, Zhu C, Ye S, Yu X, Qiao A	10.1016/J.JMB.2024.168795	2024-10-02	56200
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	8XWQ	-	4.6	EDNRB	ET_B	Endothelin	A (Rhodopsin)	Human	-	scFv16	-	ENDOTHELIN chembl_ligand pubchem	protein	Agonist	endothelin-2, endothelin-3, endothelin-1	peptide	Tani K, Maki-Yonekura S, Kanno R, Negami T, Hamaguchi T, Hall M, Mizoguchi A, Humbel BM, Terada T, Yonekura K, Doi T	10.1038/S42003-024-06905-Z	2024-10-02	56200
Gs	αs	Human	-	59	β1	Human	γ2	Human	Cryo-EM	9EW2	-	3.2	FZD7	FZD₇	Frizzled	F (Frizzled)	Human	-	Nanobody-35	-	Apo (no ligand)	none	Apo (no ligand)	-	-	-	-	2024-10-02	56198
Gs	αs	Human	-	61	β1	Human	γ2	Human	Cryo-EM	8WJX	-	3.2	P2RY1	P2Y₁	P2Y	A (Rhodopsin)	Human	BRIL	Nanobody-35	-	ADP pubchem gtoplig chembl_ligand	small-molecule	Agonist	ADP, ATP	small-molecule	-	-	2024-10-02	56198
Gi/o	αi1	Human	-	57	β1	Human	γ2	Human	Cryo-EM	8ZPS	8ZPS_refined	3.0	PRLHR	PrRP	Prolactin-releasing peptide	A (Rhodopsin)	Human	-	scFv16	-	Prolactin-releasing peptide PrRP20	peptide	Agonist	PrRP-20, PTHrP, PrRP-31, neuropeptide Y	peptide	Li Y, Yuan Q, He X, Zhang Y, You C, Wu C, Li J, Xu HE, Zhao LH	10.1038/S41421-024-00724-6	2024-09-25	56200
Gq/11	αq	Human	-	59	β1	Human	γ2	Human	Cryo-EM	8ZPT	8ZPT_refined	3.0	PRLHR	PrRP	Prolactin-releasing peptide	A (Rhodopsin)	Human	-	scFv16	-	Prolactin-releasing peptide PrRP20	peptide	Agonist	PrRP-20, PTHrP, PrRP-31, neuropeptide Y	peptide	Li Y, Yuan Q, He X, Zhang Y, You C, Wu C, Li J, Xu HE, Zhao LH	10.1038/S41421-024-00724-6	2024-09-25	56208
Gs	αs	Human	-	56	β1	Human	γ2	Human	Cryo-EM	8QJ2	8QJ2_refined	3.4	MC4R	MC₄	Melanocortin	A (Rhodopsin)	Human	-	Nanobody-35	-	pN162	protein	Apo (no ligand)	γ-MSH, α-MSH, β-MSH, ACTH, agouti-related protein	peptide	-	-	2024-09-25	56198
Gi/o	αo	Human	-	61	β1	Rat	γ2	Human	Cryo-EM	9F34	-	3.1	DRD3	D₃	Dopamine	A (Rhodopsin)	Human	-	scFv16	GFP	CHEMBL4551160 chembl_ligand pubchem	small-molecule	Agonist	dopamine	small-molecule	-	-	2024-09-18	56206
Gi/o	αi1	Human	-	61	β1	Rat	γ2	Bovine	Cryo-EM	8XOS	-	3.2	PAR1	PAR1	Proteinase-activated	A (Rhodopsin)	Human	-	scFv16	-	Tethered agonist	peptide	Agonist	thrombin	peptide	-	-	2024-09-18	56200
Gi/o	αo	Human	-	61	β1	Rat	γ2	Human	Cryo-EM	9F33	-	3.1	DRD3	D₃	Dopamine	A (Rhodopsin)	Human	-	scFv16	GFP	CHEMBL4551160 chembl_ligand pubchem	small-molecule	Agonist	dopamine	small-molecule	-	-	2024-09-18	56206
Gq/11	αq	Human	-	60	β1	Rat	γ2	Bovine	Cryo-EM	8XOR	8XOR_refined	3.0	PAR1	PAR1	Proteinase-activated	A (Rhodopsin)	Human	-	scFv16	-	Tethered agonist	peptide	Agonist	thrombin	peptide	-	-	2024-09-18	56208
Gs	αs	Human	-	57	β1	Human	γ2	Human	Cryo-EM	8YW3	8YW3_refined	2.7	GLP1R	GLP-1	Glucagon	B1 (Secretin)	Human	-	Nanobody-35	-	Retatrutide	peptide	Agonist	glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37)	peptide	Li W, Zhou Q, Cong Z, Yuan Q, Li W, Zhao F, Xu HE, Zhao LH, Yang D, Wang MW	10.1038/S41421-024-00700-0	2024-09-18	56198
Gs	αs	Human	-	60	β1	Human	γ2	Human	Cryo-EM	8YW4	8YW4_refined	3.3	GIPR	GIP	Glucagon	B1 (Secretin)	Human	-	Nanobody-35	-	Retatrutide	peptide	Agonist	gastric inhibitory polypeptide	peptide	Li W, Zhou Q, Cong Z, Yuan Q, Li W, Zhao F, Xu HE, Zhao LH, Yang D, Wang MW	10.1038/S41421-024-00700-0	2024-09-18	56198
Gi/o	αi1	Human	-	60	β1	Bovine	γ2	Bovine	Cryo-EM	9CBM	-	3.2	ADA2A	α_2A	Adrenoceptors	A (Rhodopsin)	Human	T4-Lysozyme	-	-	dexmedetomidine pubchem gtoplig chembl_ligand drugbank drug_central pubchem	small-molecule	Agonist	(-)-adrenaline, (-)-noradrenaline	small-molecule	Lou JS, Su M, Wang J, Do HN, Miao Y, Huang XY	10.1038/S12276-024-01296-X	2024-09-11	56200
Gi/o	αi1	Human	-	61	β1	Human	γ2	Human	Cryo-EM	9BQJ	-	3.3	OPRM	μ	Opioid	A (Rhodopsin)	Mouse	-	scFv16	-	N-[[3-(hydroxymethyl)phenyl]methyl]-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide pubchem	small-molecule	Agonist	-	-	-	-	2024-09-11	56200
Gi/o	αi1	Human	-	64	β1	Human	γ2	Human	Cryo-EM	8WP1	-	3.2	SUCR1	succinate	Succinate	A (Rhodopsin)	Human	-	-	-	cis-epoxysuccinic acid pubchem gtoplig chembl_ligand	small-molecule	Agonist	succinic acid	small-molecule	Liu A, Liu Y, Zhang W, Ye RD	10.1016/J.CELREP.2024.114381	2024-09-11	56200
Gi/o	αi1	Human	-	64	β1	Human	γ2	Human	Cryo-EM	8WOG	-	3.0	SUCR1	succinate	Succinate	A (Rhodopsin)	Human	-	-	-	succinic acid pubchem gtoplig chembl_ligand drugbank drug_central pubchem	small-molecule	Agonist	succinic acid	small-molecule	Liu A, Liu Y, Zhang W, Ye RD	10.1016/J.CELREP.2024.114381	2024-09-11	56200
Gi/o	αi1	Human	-	60	β1	Human	γ2	Human	Cryo-EM	9CBL	-	2.8	ADA2A	α_2A	Adrenoceptors	A (Rhodopsin)	Human	T4-Lysozyme	-	-	(-)-adrenaline pubchem gtoplig chembl_ligand drugbank drug_central pubchem pubchem	small-molecule	Agonist	(-)-adrenaline, (-)-noradrenaline	small-molecule	Lou JS, Su M, Wang J, Do HN, Miao Y, Huang XY	10.1038/S12276-024-01296-X	2024-09-11	56200
Gq/11	αq	Human	-	60	β1	Human	γ2	Human	Cryo-EM	8Y53	8Y53_refined	2.9	BRS3	BB₃	Bombesin	A (Rhodopsin)	Human	-	scFv16 Nanobody-35	-	MK-5046 pubchem gtoplig chembl_ligand	small-molecule	Agonist	-	-	-	-	2024-09-11	56208
Gq/11	αq	Human	-	60	β1	Human	γ2	Human	Cryo-EM	8Y52	8Y52_refined	2.9	BRS3	BB₃	Bombesin	A (Rhodopsin)	Human	-	-	-	Bombesin	peptide	Agonist	-	-	Li C, Xu Y, Su W, He X, Li J, Li X, Xu HE, Yin W	10.1016/J.CELREP.2024.114511	2024-09-11	56208
Gs	αs	Human	-	59	β1	Human	γ2	Human	Cryo-EM	8XVE	8XVE_refined	3.0	EDNRB	ET_B	Endothelin	A (Rhodopsin)	Human	-	Nanobody-35	Exo-alpha-sialidase	BQ3020	peptide	Agonist	endothelin-2, endothelin-3, endothelin-1	peptide	Hou J, Liu S, Zhang X, Tu G, Wu L, Zhang Y, Yang H, Li X, Liu J, Jiang L, Tan Q, Bai F, Liu Z, Miao C, Hua T, Luo Z	10.1038/S41421-024-00705-9	2024-08-28	56198
Gs	αs	Human	-	59	β1	Human	γ2	Human	Cryo-EM	8XVH	8XVH_refined	3.3	EDNRB	ET_B	Endothelin	A (Rhodopsin)	Human	-	Nanobody-35	Exo-alpha-sialidase	ENDOTHELIN chembl_ligand pubchem	protein	Agonist	endothelin-2, endothelin-3, endothelin-1	peptide	Hou J, Liu S, Zhang X, Tu G, Wu L, Zhang Y, Yang H, Li X, Liu J, Jiang L, Tan Q, Bai F, Liu Z, Miao C, Hua T, Luo Z	10.1038/S41421-024-00705-9	2024-08-28	56198
Gs	αs	Human	-	59	β1	Human	γ2	Human	Cryo-EM	8XVI	8XVI_refined	3.3	EDNRA	ET_A	Endothelin	A (Rhodopsin)	Human	-	Nanobody-35	Endoglucanase H	ENDOTHELIN chembl_ligand pubchem	protein	Agonist	endothelin-2, endothelin-3, endothelin-1	peptide	Hou J, Liu S, Zhang X, Tu G, Wu L, Zhang Y, Yang H, Li X, Liu J, Jiang L, Tan Q, Bai F, Liu Z, Miao C, Hua T, Luo Z	10.1038/S41421-024-00705-9	2024-08-28	56198
Gi/o	αi1	Human	-	66	β1	Human	γ2	Human	Cryo-EM	8JJP	-	2.9	CML2	chemerin 2	Chemerin receptor	A (Rhodopsin)	Human	-	scFv16	-	chemerin C-terminal peptide pubchem gtoplig chembl_ligand pubchem	peptide	Agonist	chemerin	peptide	-	-	2024-08-21	56200
Gi/o	αo	Human	-	97	β1	Human	γ2	Human	Cryo-EM	8U02	8U02_refined	3.3	DRD2	D₂	Dopamine	A (Rhodopsin)	Human	-	-	-	dopamine pubchem gtoplig chembl_ligand drugbank drug_central pubchem	small-molecule	Agonist	dopamine	small-molecule	Knight KM, Krumm BE, Kapolka NJ, Ludlam WG, Cui M, Mani S, Prytkova I, Obarow EG, Lefevre TJ, Wei W, Ma N, Huang XP, Fay JF, Vaidehi N, Smrcka AV, Slesinger PA, Logothetis DE, Martemyanov KA, Roth BL, Dohlman HG	10.1038/S41467-024-50964-Z	2024-08-21	56206
Gi/o	αi1	Human	-	66	β1	Human	γ2	Human	Cryo-EM	8XGM	-	3.3	CML2	chemerin 2	Chemerin receptor	A (Rhodopsin)	Human	-	scFv16	-	Retinoic acid receptor responder protein 2	protein	Agonist	chemerin	peptide	-	-	2024-08-21	56200
Gi/o	αo	Human	-	62	β1	Human	γ2	Human	Cryo-EM	8TZQ	8TZQ_refined	3.2	DRD2	D₂	Dopamine	A (Rhodopsin)	Human	-	scFv16	-	dopamine pubchem gtoplig chembl_ligand drugbank drug_central pubchem	small-molecule	Agonist	dopamine	small-molecule	Knight KM, Krumm BE, Kapolka NJ, Ludlam WG, Cui M, Mani S, Prytkova I, Obarow EG, Lefevre TJ, Wei W, Ma N, Huang XP, Fay JF, Vaidehi N, Smrcka AV, Slesinger PA, Logothetis DE, Martemyanov KA, Roth BL, Dohlman HG	10.1038/S41467-024-50964-Z	2024-08-21	56206
Gs	αs	Human	-	57	β1	Rat	γ2	Bovine	Cryo-EM	9IJD	-	2.8	ADRB3	β₃	Adrenoceptors	A (Rhodopsin)	Human	-	Camelid antibody VHH fragment	-	Carazolol pubchem	small-molecule	Inverse agonist	(-)-adrenaline, (+)-adrenaline, (-)-noradrenaline, (±)-adrenaline	small-molecule	Zheng S, Zhang S, Dai S, Chen K, Gao K, Sun X, Lin B, Liu X	10.1002/CPLU.202400288	2024-08-21	56198
Gs	αs	Human	-	57	β1	Rat	γ2	Bovine	Cryo-EM	9IJE	9IJE_refined	2.3	ADRB3	β₃	Adrenoceptors	A (Rhodopsin)	Human	-	scFv16 Camelid antibody VHH fragment	-	(-)-adrenaline pubchem gtoplig chembl_ligand drugbank drug_central pubchem pubchem	small-molecule	Agonist	(-)-adrenaline, (+)-adrenaline, (-)-noradrenaline, (±)-adrenaline	small-molecule	Zheng S, Zhang S, Dai S, Chen K, Gao K, Sun X, Lin B, Liu X	10.1002/CPLU.202400288	2024-08-21	56198
Gs	αs	Human	-	60	β1	Human	γ2	Human	Cryo-EM	8ZFJ	-	3.1	E7FEL0	GPR4	A orphans	A (Rhodopsin)	Zebrafish	BRIL	scFv16	LgBiT	Apo (no ligand)	none	Apo (no ligand)	-	-	-	-	2024-08-07	56198
Gs	αs	Human	-	57	β1	Human	γ2	Human	Cryo-EM	8YW5	8YW5_refined	2.8	GLR	glucagon	Glucagon	B1 (Secretin)	Human	-	Nanobody-35	-	Retatrutide	peptide	Agonist	glucagon	peptide	Li W, Zhou Q, Cong Z, Yuan Q, Li W, Zhao F, Xu HE, Zhao LH, Yang D, Wang MW	10.1038/S41421-024-00700-0	2024-08-07	56198
G12/13	α13	Human	-	56	β1	Human	γ2	Human	Cryo-EM	8KGG	-	3.1	P2Y10	P2RY10	A orphans	A (Rhodopsin)	Human	-	scFv16	-	(2~{S})-2-$l^{4}-azanyl-3-[[(2~{R})-3-octadecanoyloxy-2-oxidanyl-propoxy]-oxidanyl-oxidanylidene-$l^{6}-phosphanyl]oxy-propanoic acid	lipid	Agonist	LYSOPHOSPHATIDIC ACID, LPA, sphingosine 1-phosphate, 1-O-Oleoyl-D-glycerol 3-phosphoric acid	small-molecule	Yin H, Kamakura N, Qian Y, Tatsumi M, Ikuta T, Liang J, Xu Z, Xia R, Zhang A, Guo C, Inoue A, He Y	10.1016/J.CHEMBIOL.2024.08.005	2024-07-31	56213
Gi/o	αi2	Human	-	63	β1	Human	γ2	Human	Cryo-EM	8K6N	8K6N_refined	3.2	NPY2R	Y₂	Neuropeptide Y	A (Rhodopsin)	Human	-	scFv16	-	neuropeptide Y pubchem gtoplig chembl_ligand gtoplig gtoplig pubchem pubchem pubchem	peptide	Agonist	PYY-(3-36), peptide YY, neuropeptide Y-(3-36), pancreatic polypeptide, neuropeptide Y	peptide	-	-	2024-07-31	56201
Gi/o	αi2	Human	-	63	β1	Human	γ2	Human	Cryo-EM	8K6O	8K6O_refined	3.3	NPY1R	Y₁	Neuropeptide Y	A (Rhodopsin)	Human	-	scFv16	-	neuropeptide Y pubchem gtoplig chembl_ligand gtoplig gtoplig pubchem pubchem pubchem	peptide	Agonist	peptide YY, pancreatic polypeptide, neuropeptide Y	peptide	-	-	2024-07-31	56201
Gi/o	αi2	Human	-	63	β1	Human	γ2	Human	Cryo-EM	8K6M	8K6M_refined	3.3	NPY1R	Y₁	Neuropeptide Y	A (Rhodopsin)	Human	-	scFv16	-	neuropeptide Y pubchem gtoplig chembl_ligand gtoplig gtoplig pubchem pubchem pubchem	peptide	Agonist	peptide YY, pancreatic polypeptide, neuropeptide Y	peptide	-	-	2024-07-31	56201
Gi/o	αi1	Human	-	66	β1	Human	γ2	Human	Cryo-EM	8K4P	-	2.8	Q76SF8	ORF74	Unclassified	A (Rhodopsin)	HHV-8	-	-	-	Apo (no ligand)	none	Apo (no ligand)	-	-	-	-	2024-07-24	56200
Gi/o	αgust	Human	-	64	β1	Human	γ2	Human	Cryo-EM	9IIX	-	2.9	T2R14	TAS2R14	Taste 2	T2 (Taste 2)	Human	-	-	-	compound 28.1 [PMID: 36847646] pubchem gtoplig chembl_ligand compound 28.1 [PMID: 36847646] pubchem gtoplig chembl_ligand	small-molecule small-molecule	Agonist Allosteric agonist	-	-	-	-	2024-07-24	56205
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	9IJ9	-	2.7	T2R14	TAS2R14	Taste 2	T2 (Taste 2)	Human	-	-	-	Cholesterol pubchem compound 28.1 [PMID: 36847646] pubchem gtoplig chembl_ligand	small-molecule small-molecule	Agonist Allosteric agonist	-	-	-	-	2024-07-24	56200
Gi/o	αi1	Human	-	65	β1	Human	γ2	Human	Cryo-EM	8K4O	-	3.0	Q76SF8	ORF74	Unclassified	A (Rhodopsin)	HHV-8	-	-	-	Growth-regulated alpha protein	protein	Agonist	-	-	-	-	2024-07-24	56200
Gs	αs	Human	-	58	β1	Human	γ2	Human	Cryo-EM	8ZSS	-	3.1	TAAR1	TA₁	Trace amine	A (Rhodopsin)	Human	BRIL	Nanobody-35	-	RO5256390 pubchem gtoplig chembl_ligand	small-molecule	Agonist	tyramine, (+)-Octopamine, octopamine, β-phenylethylamine, CHEMBL1160703, 3-iodothyronamine, dopamine	small-molecule	-	-	2024-07-24	56198
Gs	αs	Human	-	58	β1	Human	γ2	Human	Cryo-EM	8ZSJ	-	2.8	TAAR1	TA₁	Trace amine	A (Rhodopsin)	Human	BRIL	Nanobody-35	-	Apo (no ligand)	none	Apo (no ligand)	tyramine, (+)-Octopamine, octopamine, β-phenylethylamine, CHEMBL1160703, 3-iodothyronamine, dopamine	small-molecule	Jiang K, Zheng Y, Zeng L, Wang L, Li F, Pu J, Lu Y, Zhao S, Xu F	10.1016/J.CELREP.2024.114505	2024-07-24	56198
Gs	αs	Human	-	58	β1	Human	γ2	Human	Cryo-EM	8ZSP	-	3.1	TAAR1	TA₁	Trace amine	A (Rhodopsin)	Human	BRIL	Nanobody-35	-	Lysergide pubchem gtoplig chembl_ligand drugbank drug_central	small-molecule	Agonist	tyramine, (+)-Octopamine, octopamine, β-phenylethylamine, CHEMBL1160703, 3-iodothyronamine, dopamine	small-molecule	Jiang K, Zheng Y, Zeng L, Wang L, Li F, Pu J, Lu Y, Zhao S, Xu F	10.1016/J.CELREP.2024.114505	2024-07-24	56198
Gs	αs	Human	-	58	β1	Human	γ2	Human	Cryo-EM	8ZSV	-	3.0	TAAR1	TA₁	Trace amine	A (Rhodopsin)	Mouse	BRIL	Nanobody-35	-	RO5256390 pubchem gtoplig chembl_ligand	small-molecule	Agonist	tyramine, β-phenylethylamine, 3-iodothyronamine	small-molecule	-	-	2024-07-24	56198
Gi/o	αi1	Human	-	66	β1	Human	γ2	Human	Cryo-EM	8K3Z	-	2.8	CXCR4	CXCR4	Chemokine	A (Rhodopsin)	Human	-	scFv16	-	Stromal cell-derived factor 1	peptide	Agonist	CXCL12, CXCL12β, CXCL12α, CXCL12φ, CXCL12γ, CXCL12δ, CXCL12ε	peptide	-	-	2024-07-17	56200
Gi/o	αgust	Human	-	63	β1	Human	γ2	Human	Cryo-EM	8XQP	-	3.3	T2R14	TAS2R14	Taste 2	T2 (Taste 2)	Human	-	scFv16	Exo-alpha-sialidase	aristolochic acid pubchem gtoplig chembl_ligand	small-molecule	Agonist	-	-	Hu X, Ao W, Gao M, Wu L, Pei Y, Liu S, Wu Y, Zhao F, Sun Q, Liu J, Jiang L, Wang X, Li Y, Tan Q, Cheng J, Yang F, Yang C, Sun J, Hua T, Liu ZJ	10.1038/S41586-024-07569-9	2024-07-10	56205
Gi/o	αi1	Human	-	64	β1	Human	γ2	Human	Cryo-EM	8XQN	-	3.1	T2R14	TAS2R14	Taste 2	T2 (Taste 2)	Human	-	scFv16	Exo-alpha-sialidase	aristolochic acid pubchem gtoplig chembl_ligand	small-molecule	Agonist	-	-	Hu X, Ao W, Gao M, Wu L, Pei Y, Liu S, Wu Y, Zhao F, Sun Q, Liu J, Jiang L, Wang X, Li Y, Tan Q, Cheng J, Yang F, Yang C, Sun J, Hua T, Liu ZJ	10.1038/S41586-024-07569-9	2024-07-10	56200
Gi/o	αgust	Human	-	61	β1	Human	γ2	Human	Cryo-EM	8YKY	-	3.0	T2R14	TAS2R14	Taste 2	T2 (Taste 2)	Human	-	scFv16	Exo-alpha-sialidase	compound 28.1 [PMID: 36847646] pubchem gtoplig chembl_ligand	small-molecule	Agonist	-	-	-	-	2024-07-10	56205
Gi/o	αi1	Human	-	64	β1	Human	γ2	Human	Cryo-EM	8XQS	-	3.3	T2R14	TAS2R14	Taste 2	T2 (Taste 2)	Human	-	scFv16	Exo-alpha-sialidase	flufenamic acid pubchem gtoplig chembl_ligand drugbank drug_central	small-molecule	Agonist	-	-	Hu X, Ao W, Gao M, Wu L, Pei Y, Liu S, Wu Y, Zhao F, Sun Q, Liu J, Jiang L, Wang X, Li Y, Tan Q, Cheng J, Yang F, Yang C, Sun J, Hua T, Liu ZJ	10.1038/S41586-024-07569-9	2024-07-10	56200
Gi/o	αgust	Human	-	63	β1	Human	γ2	Human	Cryo-EM	8XQL	-	3.0	T2R14	TAS2R14	Taste 2	T2 (Taste 2)	Human	-	Nanobody-35	Exo-alpha-sialidase	aristolochic acid pubchem gtoplig chembl_ligand	small-molecule	Agonist	-	-	Hu X, Ao W, Gao M, Wu L, Pei Y, Liu S, Wu Y, Zhao F, Sun Q, Liu J, Jiang L, Wang X, Li Y, Tan Q, Cheng J, Yang F, Yang C, Sun J, Hua T, Liu ZJ	10.1038/S41586-024-07569-9	2024-07-10	56205
Gi/o	αi1	Human	-	60	β1	Rat	γ2	Mouse	Cryo-EM	8ZBE	8ZBE_refined	3.2	SSR5	SST5	Somatostatin	A (Rhodopsin)	Human	-	scFv16	LgBiT	Octreotide	peptide	Agonist	CST-17, SRIF-14, cortistatin-14, SRIF-28	peptide	Li YG, Meng XY, Yang X, Ling SL, Shi P, Tian CL, Yang F	10.1038/S41401-024-01314-8	2024-07-10	56200
Gi/o	αi1	Human	-	64	β1	Human	γ2	Human	Cryo-EM	8XQT	-	2.9	T2R14	TAS2R14	Taste 2	T2 (Taste 2)	Human	-	scFv16	Exo-alpha-sialidase	Cholesterol pubchem	small-molecule	Agonist	-	-	Hu X, Ao W, Gao M, Wu L, Pei Y, Liu S, Wu Y, Zhao F, Sun Q, Liu J, Jiang L, Wang X, Li Y, Tan Q, Cheng J, Yang F, Yang C, Sun J, Hua T, Liu ZJ	10.1038/S41586-024-07569-9	2024-07-10	56200
Gi/o	αgust	Human	-	63	β1	Human	γ2	Human	Cryo-EM	8XQR	-	3.2	T2R14	TAS2R14	Taste 2	T2 (Taste 2)	Human	-	Nanobody-35	Exo-alpha-sialidase	flufenamic acid pubchem gtoplig chembl_ligand drugbank drug_central	small-molecule	Agonist	-	-	Hu X, Ao W, Gao M, Wu L, Pei Y, Liu S, Wu Y, Zhao F, Sun Q, Liu J, Jiang L, Wang X, Li Y, Tan Q, Cheng J, Yang F, Yang C, Sun J, Hua T, Liu ZJ	10.1038/S41586-024-07569-9	2024-07-10	56205
Gi/o	αi1	Human	-	64	β1	Human	γ2	Human	Cryo-EM	8XQO	-	2.8	T2R14	TAS2R14	Taste 2	T2 (Taste 2)	Human	-	scFv16	Exo-alpha-sialidase	aristolochic acid pubchem gtoplig chembl_ligand	small-molecule	Agonist	-	-	Hu X, Ao W, Gao M, Wu L, Pei Y, Liu S, Wu Y, Zhao F, Sun Q, Liu J, Jiang L, Wang X, Li Y, Tan Q, Cheng J, Yang F, Yang C, Sun J, Hua T, Liu ZJ	10.1038/S41586-024-07569-9	2024-07-10	56200
Gi/o	αi1	Human	-	63	β1	Rat	γ2	Bovine	Cryo-EM	8ZCJ	8ZCJ_refined	3.1	SSR5	SST5	Somatostatin	A (Rhodopsin)	Human	-	scFv16	LgBiT	004-DTR-LYS-TYR-PHA-HYP	peptide	Agonist	CST-17, SRIF-14, cortistatin-14, SRIF-28	peptide	Li YG, Meng XY, Yang X, Ling SL, Shi P, Tian CL, Yang F	10.1038/S41401-024-01314-8	2024-07-10	56200
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	8ZQE	8ZQE_refined	2.9	GPR15	GPR15	A orphans	A (Rhodopsin)	Human	-	scFv16	-	GPR15LG	peptide	Agonist	-	-	Zhang Z, Zheng Y, Xu L, Yue Y, Xu K, Li F, Xu F	10.1038/S41421-024-00698-5	2024-07-10	56200
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	8XIR	-	2.5	SSR3	SST3	Somatostatin	A (Rhodopsin)	Human	-	Nanobody-35	-	004-DTR-LYS-TY5-PHE-A1D5E	peptide	Agonist	CST-17, SRIF-14, cortistatin-14, SRIF-28	peptide	-	-	2024-07-03	56200
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	8XIP	-	3.3	SSR1	SST1	Somatostatin	A (Rhodopsin)	Human	-	Nanobody-35	-	004-DTR-LYS-TY5-PHE-A1D5E	peptide	Agonist	CST-17, SRIF-14, cortistatin-14, SRIF-28	peptide	-	-	2024-07-03	56200
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	8XIO	-	2.7	SSR1	SST1	Somatostatin	A (Rhodopsin)	Human	-	Nanobody-35	-	(2S)-N-[(4S)-6-amino-2,2,4-trimethylhexyl]-3-naphthalen-1-yl-2-[[2-phenylethyl(2-pyridin-2-ylethyl)carbamoyl]amino]propanamide pubchem	small-molecule	Agonist	CST-17, SRIF-14, cortistatin-14, SRIF-28	peptide	-	-	2024-07-03	56200
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	8XIQ	-	2.7	SSR3	SST3	Somatostatin	A (Rhodopsin)	Human	-	Nanobody-35	-	NIT-FC0-NLE-A1D5B	peptide	Agonist	CST-17, SRIF-14, cortistatin-14, SRIF-28	peptide	-	-	2024-07-03	56200
Gq/11	αq	Human	-	57	β1	Rat	γ2	Bovine	Cryo-EM	8ZH8	-	3.2	QRFPR	QRFP	Peptide P518	A (Rhodopsin)	Human	-	scFv16	-	QRF-amide	peptide	Agonist	QRFP26 (26RFa), QRFP43, QRFP43 (43RFa)	peptide	Iwama A, Kise R, Akasaka H, Sano FK, Oshima HS, Inoue A, Shihoya W, Nureki O	10.1038/S41467-024-49030-5	2024-07-03	56208
Gq/11	αq	Human	-	63	β1	Human	γ2	Human	Cryo-EM	8ZJE	-	3.1	KISSR	kisspeptin	Kisspeptin	A (Rhodopsin)	Human	-	scFv16	-	ACY-DTY-HYP-ASN-THR-PHE-XZA-LEU-NMM-TRP-NH2	peptide	Agonist	kisspeptin-13, kisspeptin-54, kisspeptin-14, kisspeptin-52, kisspeptin-10	peptide	-	-	2024-07-03	56208
Gq/11	αq	Human	-	63	β1	Human	γ2	Human	Cryo-EM	8ZJD	-	3.1	KISSR	kisspeptin	Kisspeptin	A (Rhodopsin)	Human	-	scFv16	-	Kisspeptin-10 pubchem	peptide	Agonist	kisspeptin-13, kisspeptin-54, kisspeptin-14, kisspeptin-52, kisspeptin-10	peptide	-	-	2024-07-03	56208
Gi/o	αi1	Human	-	63	β1	Human	γ2	Human	Cryo-EM	9ERX	9ERX_refined	2.9	CNR1	CB₁	Cannabinoid	A (Rhodopsin)	Human	-	scFv16	-	HU-210 pubchem gtoplig chembl_ligand	small-molecule	Agonist	2-arachidonoylglycerol, anandamide	small-molecule	-	-	2024-06-26	56200
Gi/o	αi1	Human	-	61	β1	Human	γ2	Human	Cryo-EM	8WSS	8WSS_refined	3.0	MCHR1	MCH₁	Melanin-concentrating hormone	A (Rhodopsin)	Human	-	scFv16	-	pro-MCH	peptide	Agonist	melanin-concentrating hormone	peptide	He Q, Yuan Q, Shan H, Wu C, Gu Y, Wu K, Hu W, Zhang Y, He X, Xu HE, Zhao LH	10.1038/S41421-024-00679-8	2024-06-19	56200
Gq/11	αq	Human	-	59	β1	Human	γ2	Human	Cryo-EM	8WST	8WST_refined	2.4	MCHR2	MCH₂	Melanin-concentrating hormone	A (Rhodopsin)	Human	-	Nanobody-35	-	pro-MCH	peptide	Agonist	melanin-concentrating hormone	peptide	He Q, Yuan Q, Shan H, Wu C, Gu Y, Wu K, Hu W, Zhang Y, He X, Xu HE, Zhao LH	10.1038/S41421-024-00679-8	2024-06-19	56208
Gq/11	αq	Human	-	60	β1	Rat	γ2	Bovine	Cryo-EM	8WZ2	8WZ2_refined	2.7	QRFPR	QRFP	Peptide P518	A (Rhodopsin)	Human	-	scFv16	-	Orexigenic neuropeptide QRFP	peptide	Agonist	QRFP26 (26RFa), QRFP43, QRFP43 (43RFa)	peptide	Jin S, Guo S, Xu Y, Li X, Wu C, He X, Pan B, Xin W, Zhang H, Hu W, Yin Y, Zhang T, Wu K, Yuan Q, Xu HE, Xie X, Jiang Y	10.1038/S41421-024-00670-3	2024-06-19	56208
Gs	αs	Human	-	60	β1	Human	γ2	Human	Cryo-EM	8ZRK	-	2.8	GP119	GPR119	GPR18, GPR55 and GPR119	A (Rhodopsin)	Human	-	Nanobody-35	-	GSK-1292263 chembl_ligand pubchem	small-molecule	Agonist	N-oleoylethanolamide, N-palmitoylethanolamine, SEA, anandamide	small-molecule	-	-	2024-06-19	56198
Gs	αs	Human	-	60	β1	Human	γ2	Human	Cryo-EM	8ZR5	-	3.3	GP119	GPR119	GPR18, GPR55 and GPR119	A (Rhodopsin)	Human	-	Nanobody-35	-	DS-8500a pubchem gtoplig	small-molecule	Agonist	N-oleoylethanolamide, N-palmitoylethanolamine, SEA, anandamide	small-molecule	-	-	2024-06-19	56198
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	8X8L	8X8L_refined	2.7	SSR5	SST5	Somatostatin	A (Rhodopsin)	Human	-	scFv16	-	Cortistatin	peptide	Agonist	CST-17, SRIF-14, cortistatin-14, SRIF-28	peptide	-	-	2024-06-12	56200
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	8X8N	8X8N_refined	2.9	SSR5	SST5	Somatostatin	A (Rhodopsin)	Human	-	scFv16	-	Octreotide pubchem	peptide	Agonist	CST-17, SRIF-14, cortistatin-14, SRIF-28	peptide	-	-	2024-06-12	56200
Gi/o	αi1	Human	-	64	β1	Human	γ2	Human	Cryo-EM	8YUV	-	3.0	HRH3	H₃	Histamine	A (Rhodopsin)	Human	-	-	-	immepip pubchem gtoplig chembl_ligand	small-molecule	Agonist	histamine	small-molecule	-	-	2024-06-05	56200
Gi/o	αi1	Human	-	61	β1	Human	γ2	Human	Cryo-EM	8IKH	8IKH_refined	3.3	CNR1	CB₁	Cannabinoid	A (Rhodopsin)	Human	-	scFv16	-	3-[(1R)-1-(2-methoxyphenyl)-2-nitro-ethyl]-2-phenyl-1H-indole pubchem	small-molecule	Agonist	2-arachidonoylglycerol, anandamide	small-molecule	Shen S, Wu C, Lin G, Yang X, Zhou Y, Zhao C, Miao Z, Tian X, Wang K, Yang Z, Liu Z, Guo N, Li Y, Xia A, Zhou P, Liu J, Yan W, Ke B, Yang S, Shao Z	10.1073/PNAS.2321532121	2024-06-05	56200
Gi/o	αi1	Human	-	64	β1	Human	γ2	Human	Cryo-EM	8YUU	-	2.7	HRH3	H₃	Histamine	A (Rhodopsin)	Human	-	scFv16	-	histamine pubchem gtoplig chembl_ligand drug_central drugbank gtoplig pubchem	small-molecule	Agonist	histamine	small-molecule	Shen Q, Tang X, Wen X, Cheng S, Xiao P, Zang SK, Shen DD, Jiang L, Zheng Y, Zhang H, Xu H, Mao C, Zhang M, Hu W, Sun JP, Zhang Y, Chen Z	10.1002/ADVS.202310120	2024-06-05	56200
Gi/o	αi1	Human	-	61	β1	Human	γ2	Human	Cryo-EM	8IKG	8IKG_refined	3.4	CNR1	CB₁	Cannabinoid	A (Rhodopsin)	Human	-	scFv16	-	3-[(1S)-1-(furan-2-yl)-2-nitro-ethyl]-2-phenyl-1H-indole pubchem	small-molecule	Agonist	2-arachidonoylglycerol, anandamide	small-molecule	Shen S, Wu C, Lin G, Yang X, Zhou Y, Zhao C, Miao Z, Tian X, Wang K, Yang Z, Liu Z, Guo N, Li Y, Xia A, Zhou P, Liu J, Yan W, Ke B, Yang S, Shao Z	10.1073/PNAS.2321532121	2024-06-05	56200
Gs	αs	Human	-	58	β1	Human	γ2	Human	Cryo-EM	8YUT	-	2.7	HRH2	H₂	Histamine	A (Rhodopsin)	Human	-	Nanobody-35	-	amthamine pubchem gtoplig chembl_ligand	small-molecule	Agonist	histamine	small-molecule	-	-	2024-06-05	56198
Gi/o	αi1	Human	-	61	β1	Human	γ2	Human	Cryo-EM	8PKM	-	2.9	5HT1A	5-HT_1A	5-Hydroxytryptamine	A (Rhodopsin)	Human	-	-	-	BEFIRADOL chembl_ligand pubchem pubchem (2r)-1-(Heptadecanoyloxy)-3-{[(R)-Hydroxy{[(1r,2r,3r,4r,5s,6r)-2,3,5,6-Tetrahydroxy-4-(Phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propan-2-Yl (5z,8z,11z,14z)-Icosa-5,8,11,14-Tetraenoate pubchem	small-molecule small-molecule	Agonist PAM	5-hydroxytryptamine	small-molecule	-	-	2024-05-29	56200
Gi/o	αi1	Human	-	60	β1	Rat	γ2	Bovine	Cryo-EM	8YKV	-	2.5	SUCR1	succinate	Succinate	A (Rhodopsin)	Human	-	scFv16	-	CHEMBL5430997 chembl_ligand pubchem	small-molecule	Agonist	succinic acid	small-molecule	-	-	2024-05-29	56200
Gi/o	αi1	Human	-	60	β1	Rat	γ2	Bovine	Cryo-EM	8YKW	8YKW_refined	2.8	SUCR1	succinate	Succinate	A (Rhodopsin)	Human	-	scFv16	-	succinic acid pubchem gtoplig chembl_ligand drugbank drug_central pubchem	small-molecule	Agonist	succinic acid	small-molecule	Li C, Liu H, Li J, He X, Zhu H, Fu W, Xu HE	10.1038/S41422-024-00984-7	2024-05-29	56200
Gi/o	αi1	Human	-	63	β1	Human	γ2	Human	Cryo-EM	8PJK	-	2.4	5HT1A	5-HT_1A	5-Hydroxytryptamine	A (Rhodopsin)	Human	-	-	-	6-[3-[2-(2-methoxyphenoxy)ethylamino]propoxy]-4~{H}-1,4-benzoxazin-3-one pubchem (2r)-1-(Heptadecanoyloxy)-3-{[(R)-Hydroxy{[(1r,2r,3r,4r,5s,6r)-2,3,5,6-Tetrahydroxy-4-(Phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propan-2-Yl (5z,8z,11z,14z)-Icosa-5,8,11,14-Tetraenoate pubchem	small-molecule small-molecule	Agonist PAM	5-hydroxytryptamine	small-molecule	-	-	2024-05-29	56200
Gi/o	αi3	Rhesus macaque	-	63	β1	Human	γ2	Human	Cryo-EM	8K9K	-	3.0	OPRM	μ	Opioid	A (Rhodopsin)	Human	BRIL	scFv16	-	DAMGO pubchem gtoplig chembl_ligand chembl_ligand	peptide	Agonist	dynorphin B, dynorphin A-(1-13), dynorphin A-(1-8), β-endorphin, [Met]enkephalin, dynorphin A, [Leu]enkephalin, endomorphin-1, endomorphin-2	peptide	Kaneko S, Imai S, Uchikubo-Kamo T, Hisano T, Asao N, Shirouzu M, Shimada I	10.1038/S41467-024-47792-6	2024-05-29	56297
Gi/o	αi3	Rhesus macaque	-	63	β1	Human	γ2	Human	Cryo-EM	8K9L	-	3.1	OPRM	μ	Opioid	A (Rhodopsin)	Human	BRIL	scFv16	-	DAMGO pubchem gtoplig chembl_ligand chembl_ligand (2~{S})-2-(3-bromanyl-4-methoxy-phenyl)-3-(4-chlorophenyl)sulfonyl-1,3-thiazolidine pubchem	peptide small-molecule	Agonist PAM	dynorphin B, dynorphin A-(1-13), dynorphin A-(1-8), β-endorphin, [Met]enkephalin, dynorphin A, [Leu]enkephalin, endomorphin-1, endomorphin-2	peptide	Kaneko S, Imai S, Uchikubo-Kamo T, Hisano T, Asao N, Shirouzu M, Shimada I	10.1038/S41467-024-47792-6	2024-05-29	56297
Gi/o	αi1	Human	-	60	β1	Rat	γ2	Bovine	Cryo-EM	8YKX	8YKX_refined	2.7	SUCR1	succinate	Succinate	A (Rhodopsin)	Human	-	scFv16	-	maleic acid pubchem gtoplig chembl_ligand drugbank	small-molecule	Agonist	succinic acid	small-molecule	Li C, Liu H, Li J, He X, Zhu H, Fu W, Xu HE	10.1038/S41422-024-00984-7	2024-05-29	56200
Gq/11	αq	Human	Gi2-mini-Gq chimera	57	β1	Human	γ2	Human	Cryo-EM	8V6U	-	3.0	5HT2A	5-HT_2A	5-Hydroxytryptamine	A (Rhodopsin)	Human	-	scFv16	-	4-{(3R)-1-[(1R)-1-(pyrimidin-2-yl)ethyl]piperidin-3-yl}phenol pubchem	small-molecule	Agonist	tryptamine, 5-hydroxytryptamine	small-molecule	Lyu J, Kapolka N, Gumpper R, Alon A, Wang L, Jain MK, Barros-Alvarez X, Sakamoto K, Kim Y, DiBerto J, Kim K, Glenn IS, Tummino TA, Huang S, Irwin JJ, Tarkhanova OO, Moroz Y, Skiniotis G, Kruse AC, Shoichet BK, Roth BL	10.1126/SCIENCE.ADN6354	2024-05-29	56208
Gq/11	αq	Human	Gi2-mini-Gq chimera	58	β1	Human	γ2	Human	Cryo-EM	8UWL	-	2.8	5HT2A	5-HT_2A	5-Hydroxytryptamine	A (Rhodopsin)	Human	-	scFv16	-	lisuride pubchem gtoplig chembl_ligand drugbank drug_central pubchem	small-molecule	Agonist	tryptamine, 5-hydroxytryptamine	small-molecule	Lyu J, Kapolka N, Gumpper R, Alon A, Wang L, Jain MK, Barros-Alvarez X, Sakamoto K, Kim Y, DiBerto J, Kim K, Glenn IS, Tummino TA, Huang S, Irwin JJ, Tarkhanova OO, Moroz Y, Skiniotis G, Kruse AC, Shoichet BK, Roth BL	10.1126/SCIENCE.ADN6354	2024-05-29	56208
Gi/o	αi1	Human	-	64	β1	Human	γ2	Human	Cryo-EM	8JPN	-	2.9	SUCR1	succinate	Succinate	A (Rhodopsin)	Human	BRIL	scFv16	-	cis-epoxysuccinic acid pubchem gtoplig chembl_ligand	small-molecule	Agonist	succinic acid	small-molecule	-	-	2024-05-22	56200
Gq/11	αq	Human	Gs-min-Gq chimera	57	β1	Human	γ2	Human	Cryo-EM	8YRG	8YRG_refined	3.1	MRGX4	MRGPRX4	A orphans	A (Rhodopsin)	Human	BRIL	scFv16	-	Fospropofol pubchem	small-molecule	Agonist	-	-	-	-	2024-05-22	56208
Gs	αs	Human	-	60	β1	Human	γ2	Human	Cryo-EM	8JPP	-	3.2	SUCR1	succinate	Succinate	A (Rhodopsin)	Human	BRIL	-	-	succinic acid pubchem gtoplig chembl_ligand drugbank drug_central pubchem	small-molecule	Agonist	succinic acid	small-molecule	Wang T, Tang W, Zhu X, Lv Z, Chen J, Li Y, Sun X, Lv H, Gu Q, Li F, Wang J	10.1038/S41422-024-00968-7	2024-05-22	56198
Gs	αs	Human	Gs-Gi chimera	52	β1	Human	γ2	Human	Cryo-EM	9BKJ	-	2.6	CCKAR	CCK₁	Cholecystokinin	A (Rhodopsin)	Human	-	-	-	CHEMBL216166 chembl_ligand pubchem	protein	Agonist	CCK-39, gastrin-17, desulfated cholecystokinin-8, CCK-4, CCK-58, CCK-8, CCK-33	peptide	Harikumar KG, Zhao P, Cary BP, Xu X, Desai AJ, Dong M, Mobbs JI, Toufaily C, Furness SGB, Christopoulos A, Belousoff MJ, Wootten D, Sexton PM, Miller LJ	10.1371/JOURNAL.PBIO.3002673	2024-05-22	56198
Gs	αs	Human	-	52	β1	Human	γ2	Human	Cryo-EM	9BKK	-	2.5	CCKAR	CCK₁	Cholecystokinin	A (Rhodopsin)	Human	-	-	-	CHEMBL216166 chembl_ligand pubchem	protein	Agonist	CCK-39, gastrin-17, desulfated cholecystokinin-8, CCK-4, CCK-58, CCK-8, CCK-33	peptide	Harikumar KG, Zhao P, Cary BP, Xu X, Desai AJ, Dong M, Mobbs JI, Toufaily C, Furness SGB, Christopoulos A, Belousoff MJ, Wootten D, Sexton PM, Miller LJ	10.1371/JOURNAL.PBIO.3002673	2024-05-22	56198
Gi/o	αi1	Human	-	66	β1	Human	γ2	Human	Cryo-EM	8FY8	-	2.8	5HT1A	5-HT_1A	5-Hydroxytryptamine	A (Rhodopsin)	Human	BRIL	-	-	5-MeO-DMT pubchem gtoplig chembl_ligand drugbank	small-molecule	Agonist	5-hydroxytryptamine	small-molecule	Warren AL, Lankri D, Cunningham MJ, Serrano IC, Parise LF, Kruegel AC, Duggan P, Zilberg G, Capper MJ, Havel V, Russo SJ, Sames D, Wacker D	10.1038/S41586-024-07403-2	2024-05-15	56200
Gi/o	αi1	Human	-	66	β1	Human	γ2	Human	Cryo-EM	8FYT	-	2.6	5HT1A	5-HT_1A	5-Hydroxytryptamine	A (Rhodopsin)	Human	BRIL	-	-	Lysergide pubchem gtoplig chembl_ligand drugbank drug_central	small-molecule	Agonist	5-hydroxytryptamine	small-molecule	Warren AL, Lankri D, Cunningham MJ, Serrano IC, Parise LF, Kruegel AC, Duggan P, Zilberg G, Capper MJ, Havel V, Russo SJ, Sames D, Wacker D	10.1038/S41586-024-07403-2	2024-05-15	56200
Gi/o	αi1	Human	-	62	β1	Rat	γ2	Bovine	Cryo-EM	8XBE	8XBE_refined	3.4	GPR34	GPR34	A orphans	A (Rhodopsin)	Human	-	scFv16	-	CHEMBL4782438 chembl_ligand pubchem	small-molecule	Agonist	lysophosphatidylserine	small-molecule	Izume T, Kawahara R, Uwamizu A, Chen L, Yaginuma S, Omi J, Kawana H, Hou F, Sano FK, Tanaka T, Kobayashi K, Okamoto HH, Kise Y, Ohwada T, Aoki J, Shihoya W, Nureki O	10.1038/S41467-024-45046-Z	2024-05-15	56200
Gi/o	αi1	Human	-	66	β1	Human	γ2	Human	Cryo-EM	8FYL	-	2.9	5HT1A	5-HT_1A	5-Hydroxytryptamine	A (Rhodopsin)	Human	BRIL	-	-	vilazodone pubchem gtoplig chembl_ligand drugbank drug_central pubchem	small-molecule	Agonist	5-hydroxytryptamine	small-molecule	Warren AL, Lankri D, Cunningham MJ, Serrano IC, Parise LF, Kruegel AC, Duggan P, Zilberg G, Capper MJ, Havel V, Russo SJ, Sames D, Wacker D	10.1038/S41586-024-07403-2	2024-05-15	56200
Gi/o	αi1	Human	-	66	β1	Human	γ2	Human	Cryo-EM	8FYE	-	2.9	5HT1A	5-HT_1A	5-Hydroxytryptamine	A (Rhodopsin)	Human	BRIL	-	-	CHEMBL352186 chembl_ligand pubchem	small-molecule	Agonist	5-hydroxytryptamine	small-molecule	Warren AL, Lankri D, Cunningham MJ, Serrano IC, Parise LF, Kruegel AC, Duggan P, Zilberg G, Capper MJ, Havel V, Russo SJ, Sames D, Wacker D	10.1038/S41586-024-07403-2	2024-05-15	56200
Gi/o	αi1	Human	-	66	β1	Human	γ2	Human	Cryo-EM	8FYX	-	2.6	5HT1A	5-HT_1A	5-Hydroxytryptamine	A (Rhodopsin)	Human	BRIL	-	-	buspirone pubchem gtoplig chembl_ligand drugbank drug_central pubchem	small-molecule	Agonist	5-hydroxytryptamine	small-molecule	Warren AL, Lankri D, Cunningham MJ, Serrano IC, Parise LF, Kruegel AC, Duggan P, Zilberg G, Capper MJ, Havel V, Russo SJ, Sames D, Wacker D	10.1038/S41586-024-07403-2	2024-05-15	56200
Gi/o	αi3	Human	-	91	-	-	-	-	X-ray	8OY1	-	3.3	-	-	-	-	-	-	-	-	-	-	-	-	-	Ferreras-Gutierrez M, Minguez-Toral M, Ibanez de Opakua A, Martin-Santamaria S, Garcia-Marcos M, Medrano FJ, Blanco FJ	39706421	2024-05-15	56202
Gi/o	αi1	Human	-	61	β1	Human	γ2	Human	Cryo-EM	8UH3	-	3.3	5HT1E	5-HT_1E	5-Hydroxytryptamine	A (Rhodopsin)	Human	-	scFv16	-	SETIPTILINE chembl_ligand pubchem	small-molecule	Agonist	tryptamine, 5-hydroxytryptamine	small-molecule	Zilberg G, Parpounas AK, Warren AL, Fiorillo B, Provasi D, Filizola M, Wacker D	10.1126/SCIADV.ADK4855	2024-05-01	56200
Gi/o	αi1	Human	-	61	β1	Human	γ2	Human	Cryo-EM	8UGY	-	3.3	5HT1E	5-HT_1E	5-Hydroxytryptamine	A (Rhodopsin)	Human	-	-	-	CHEMBL252719 chembl_ligand pubchem	small-molecule	Agonist	tryptamine, 5-hydroxytryptamine	small-molecule	Zilberg G, Parpounas AK, Warren AL, Fiorillo B, Provasi D, Filizola M, Wacker D	10.1126/SCIADV.ADK4855	2024-05-01	56200
Gi/o	αi1	Human	-	61	β1	Rat	γ2	Bovine	Cryo-EM	8X17	8X17_refined	3.2	AA3R	A₃	Adenosine	A (Rhodopsin)	Human	-	scFv16	-	Cl-IB-MECA pubchem gtoplig chembl_ligand drugbank pubchem	small-molecule	Agonist	adenosine	small-molecule	Cai H, Guo S, Xu Y, Sun J, Li J, Xia Z, Jiang Y, Xie X, Xu HE	10.1038/S41467-024-47207-6	2024-04-24	56200
Gi/o	αi1	Human	-	61	β1	Rat	γ2	Bovine	Cryo-EM	8X16	8X16_refined	3.3	AA3R	A₃	Adenosine	A (Rhodopsin)	Human	-	scFv16	-	piclidenoson pubchem gtoplig chembl_ligand drugbank	small-molecule	Agonist	adenosine	small-molecule	Cai H, Guo S, Xu Y, Sun J, Li J, Xia Z, Jiang Y, Xie X, Xu HE	10.1038/S41467-024-47207-6	2024-04-24	56200
Gs	αs	Human	-	59	β1	Human	γ2	Human	Cryo-EM	8YY8	-	3.2	FZD7	FZD₇	Frizzled	F (Frizzled)	Human	-	Nanobody-35	-	Apo (no ligand)	none	Apo (no ligand)	-	-	Xu L, Chen B, Schihada H, Wright SC, Turku A, Wu Y, Han GW, Kowalski-Jahn M, Kozielewicz P, Bowin CF, Zhang X, Li C, Bouvier M, Schulte G, Xu F	10.1038/S41422-021-00525-6	2024-04-24	56198
Gs	αs	Human	-	59	β1	Human	γ2	Human	Cryo-EM	9AUC	-	2.4	CALCR	CT	Calcitonin	B1 (Secretin)	Human	-	Nanobody-35 RAMP1	-	Calcitonin gene-related peptide 1 pubchem	peptide	Agonist	adrenomedullin, calcitonin, β-CGRP, adrenomedullin 2/intermedin, α-CGRP, amylin	peptide	Cao J, Belousoff MJ, Danev R, Christopoulos A, Wootten D, Sexton PM	10.1021/ACS.BIOCHEM.4C00114	2024-04-24	56198
Gi/o	αi1	Human	-	60	β1	Human	γ2	Human	Cryo-EM	9AYF	-	3.6	CASR	CaS	Calcium-sensing	C (Glutamate)	Human	-	scFv16	-	Cyclomethyltryptophan pubchem tecalcet pubchem gtoplig chembl_ligand	small-molecule small-molecule	Agonist PAM	Mg²⁺, L-tryptophan, spermine, Ca²⁺	small-molecule	Zuo H, Park J, Frangaj A, Ye J, Lu G, Manning JJ, Asher WB, Lu Z, Hu GB, Wang L, Mendez J, Eng E, Zhang Z, Lin X, Grassucci R, Hendrickson WA, Clarke OB, Javitch JA, Conigrave AD, Fan QR	10.1038/S41586-024-07331-1	2024-04-17	56200
Gi/o	αi1	Human	-	61	β1	Human	γ2	Human	Cryo-EM	8J23	8J23_refined	3.2	FFAR2	FFA2	Free fatty acid	A (Rhodopsin)	Human	-	scFv16	-	Apo (no ligand)	none	Apo (no ligand)	butyric acid, acetic acid, trans-2-methylcrotonic acid, propanoic acid	small-molecule	-	-	2024-04-17	56200
Gi/o	αi3	Human	-	64	β1	Human	γ2	Human	Cryo-EM	9AVL	-	3.8	CASR	CaS	Calcium-sensing	C (Glutamate)	Human	-	-	-	Cyclomethyltryptophan pubchem tecalcet pubchem gtoplig chembl_ligand	small-molecule small-molecule	Agonist PAM	Mg²⁺, L-tryptophan, spermine, Ca²⁺	small-molecule	-	-	2024-04-17	56202
Gq/11	αq	Human	-	60	β1	Human	γ2	Human	Cryo-EM	9ASB	-	3.4	CASR	CaS	Calcium-sensing	C (Glutamate)	Human	-	-	-	Cyclomethyltryptophan pubchem tecalcet pubchem gtoplig chembl_ligand	small-molecule small-molecule	Agonist PAM	Mg²⁺, L-tryptophan, spermine, Ca²⁺	small-molecule	-	-	2024-04-17	56208
Gq/11	αq	Human	Gq-Gs-Gi chimera	59	β1	Human	γ2	Human	Cryo-EM	9AXF	-	3.5	CASR	CaS	Calcium-sensing	C (Glutamate)	Human	-	scFv16	-	Cyclomethyltryptophan pubchem tecalcet pubchem gtoplig chembl_ligand	small-molecule small-molecule	Agonist PAM	Mg²⁺, L-tryptophan, spermine, Ca²⁺	small-molecule	Zuo H, Park J, Frangaj A, Ye J, Lu G, Manning JJ, Asher WB, Lu Z, Hu GB, Wang L, Mendez J, Eng E, Zhang Z, Lin X, Grassucci R, Hendrickson WA, Clarke OB, Javitch JA, Conigrave AD, Fan QR	10.1038/S41586-024-07331-1	2024-04-17	56208
Gs	αs	Human	-	57	β1	Human	γ2	Human	Cryo-EM	9AVG	-	3.6	CASR	CaS	Calcium-sensing	C (Glutamate)	Human	-	-	-	Cyclomethyltryptophan pubchem tecalcet pubchem gtoplig chembl_ligand	small-molecule small-molecule	Agonist PAM	Mg²⁺, L-tryptophan, spermine, Ca²⁺	small-molecule	-	-	2024-04-17	56198
Gi/o	αi1	Human	-	63	β1	Human	γ2	Human	Cryo-EM	8IZ4	-	2.9	GPR34	GPR34	A orphans	A (Rhodopsin)	Human	-	scFv16	-	Lysergide pubchem gtoplig chembl_ligand drugbank drug_central	small-molecule	Agonist	lysophosphatidylserine	small-molecule	-	-	2024-04-10	56200
Gq/11	αq	Human	-	59	β1	Human	γ2	Human	Cryo-EM	8XOJ	8XOJ_refined	3.1	GPER1	GPER	Estrogen (G protein-coupled)	A (Rhodopsin)	Human	-	scFv16	-	-	-	-	17β-estradiol	small-molecule	Liu H, Guo S, Dai A, Xu P, Li X, Huang S, He X, Wu K, Zhang X, Yang D, Xie X, Xu HE	10.1038/S41422-024-00963-Y	2024-04-10	56208
Gq/11	αq	Human	-	59	β1	Human	γ2	Human	Cryo-EM	8XOG	-	2.9	GPER1	GPER	Estrogen (G protein-coupled)	A (Rhodopsin)	Human	-	scFv16	-	Apo (no ligand)	none	Apo (no ligand)	17β-estradiol	small-molecule	Liu H, Guo S, Dai A, Xu P, Li X, Huang S, He X, Wu K, Zhang X, Yang D, Xie X, Xu HE	10.1038/S41422-024-00963-Y	2024-04-10	56208
Gq/11	αq	Human	-	59	β1	Human	γ2	Human	Cryo-EM	8XOI	8XOI_refined	3.2	GPER1	GPER	Estrogen (G protein-coupled)	A (Rhodopsin)	Human	-	scFv16	-	fulvestrant pubchem gtoplig chembl_ligand drugbank drug_central	small-molecule	Agonist	17β-estradiol	small-molecule	Liu H, Guo S, Dai A, Xu P, Li X, Huang S, He X, Wu K, Zhang X, Yang D, Xie X, Xu HE	10.1038/S41422-024-00963-Y	2024-04-10	56208
Gq/11	αq	Human	-	59	β1	Human	γ2	Human	Cryo-EM	8XOH	8XOH_refined	3.2	GPER1	GPER	Estrogen (G protein-coupled)	A (Rhodopsin)	Human	-	scFv16	-	PGE₂ pubchem gtoplig chembl_ligand drugbank drug_central gtoplig pubchem	small-molecule	Agonist	17β-estradiol	small-molecule	Liu H, Guo S, Dai A, Xu P, Li X, Huang S, He X, Wu K, Zhang X, Yang D, Xie X, Xu HE	10.1038/S41422-024-00963-Y	2024-04-10	56208
Gq/11	αq	Human	-	59	β1	Human	γ2	Human	Cryo-EM	8XOF	8XOF_refined	2.6	GPER1	GPER	Estrogen (G protein-coupled)	A (Rhodopsin)	Human	-	Nanobody-35	-	N1-(7-Chloroquinolin-4-yl)-N2-(2-((7-chloroquinolin-4-yl)amino)ethyl)-N2-methylethane-1,2-diamine pubchem	small-molecule	Agonist	17β-estradiol	small-molecule	-	-	2024-04-10	56208
Gi/o	αgust	Human	-	63	β1	Human	γ2	Human	Cryo-EM	8VY9	-	2.9	T2R14	TAS2R14	Taste 2	T2 (Taste 2)	Human	-	scFv16	-	compound 28.1 [PMID: 36847646] pubchem gtoplig chembl_ligand	small-molecule	Agonist	-	-	-	-	2024-04-03	56205
Gi/o	αt1	Bovine	-	59	β1	Rat	γ2	Bovine	Cryo-EM	8XGR	-	3.2	EDNRB	ET_B	Endothelin	A (Rhodopsin)	Human	-	Camelid antibody VHH fragment	-	ENDOTHELIN chembl_ligand pubchem	protein	Agonist	endothelin-2, endothelin-3, endothelin-1	peptide	-	-	2024-04-03	56310
Gi/o	αi1	Human	-	61	β1	Human	γ2	Human	Cryo-EM	8J6I	8J6I_refined	2.9	HCAR2	HCA₂	Hydroxycarboxylic acid	A (Rhodopsin)	Human	-	scFv16	-	MK 6892 pubchem gtoplig chembl_ligand pubchem	small-molecule	Agonist	butyric acid, β-D-hydroxybutyric acid	small-molecule	-	-	2024-04-03	56200
Gi/o	αi1	Human	-	63	β1	Human	γ2	Human	Cryo-EM	8VY7	-	2.7	T2R14	TAS2R14	Taste 2	T2 (Taste 2)	Human	-	scFv16	-	compound 28.1 [PMID: 36847646] pubchem gtoplig chembl_ligand	small-molecule	Agonist	-	-	-	-	2024-04-03	56200
Gi/o	αi1	Human	-	61	β1	Human	γ2	Human	Cryo-EM	8J6L	8J6L_refined	3.1	HCAR2	HCA₂	Hydroxycarboxylic acid	A (Rhodopsin)	Human	-	scFv16	-	nicotinic acid pubchem gtoplig chembl_ligand drugbank drug_central gtoplig pubchem	small-molecule	Agonist	butyric acid, β-D-hydroxybutyric acid	small-molecule	Zhu S, Yuan Q, Li X, He X, Shen S, Wang D, Li J, Cheng X, Duan X, Xu HE, Duan J	10.1016/J.CELREP.2023.113406	2024-04-03	56200
Gs	αs	Human	-	55	β1	Human	γ2	Human	Cryo-EM	8X2K	-	3.0	GPR3	GPR3	A orphans	A (Rhodopsin)	Human	BRIL	scFv16	-	N-oleoylethanolamide pubchem gtoplig chembl_ligand	small-molecule	Agonist	sphingosine 1-phosphate	small-molecule	Chen G, Staffen N, Wu Z, Xu X, Pan J, Inoue A, Shi T, Gmeiner P, Du Y, Xu J	10.1038/S41422-023-00919-8	2024-04-03	56198
Gi/o	αi1	Human	-	59	β1	Human	γ2	Bovine	Cryo-EM	8IU2	8IU2_refined	3.4	OPSR	OPN1LW	Opsins	A (Rhodopsin)	Human	-	scFv16	-	Retinal (11-cis) pubchem	small-molecule	Agonist	-	-	-	-	2024-03-27	56200
Gi/o	αi1	Human	-	61	β1	Human	γ2	Human	Cryo-EM	8XZG	8XZG_refined	3.2	APJ	apelin	Apelin	A (Rhodopsin)	Human	-	-	-	[Pyr¹]apelin-13 gtoplig pubchem	peptide	Agonist	apelin-13, apelin-36, apelin-17, Elabela/Toddler-21, Elabela/Toddler-32, Elabela/Toddler-11, apelin receptor early endogenous ligand, [Pyr¹]apelin-13	peptide	Wang WW, Ji SY, Zhang W, Zhang J, Cai C, Hu R, Zang SK, Miao L, Xu H, Chen LN, Yang Z, Guo J, Qin J, Shen DD, Liang P, Zhang Y, Zhang Y	10.1016/J.CELL.2024.02.004	2024-03-27	56200
Gi/o	αi1	Human	-	58	β1	Human	γ2	Human	Cryo-EM	8JXV	-	3.2	HRH4	H₄	Histamine	A (Rhodopsin)	Human	-	scFv16	-	clozapine pubchem gtoplig chembl_ligand drugbank drug_central pubchem	small-molecule	Agonist	histamine, CCL16	small-molecule	Xia R, Shi S, Xu Z, Vischer HF, Windhorst AD, Qian Y, Duan Y, Liang J, Chen K, Zhang A, Guo C, Leurs R, He Y	10.1038/S41467-024-46840-5	2024-03-20	56200
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	8JXW	8JXW_refined	3.0	HRH4	H₄	Histamine	A (Rhodopsin)	Human	-	scFv16	-	CHEMBL213912 chembl_ligand pubchem	small-molecule	Agonist	histamine, CCL16	small-molecule	Xia R, Shi S, Xu Z, Vischer HF, Windhorst AD, Qian Y, Duan Y, Liang J, Chen K, Zhang A, Guo C, Leurs R, He Y	10.1038/S41467-024-46840-5	2024-03-20	56200
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	8XZJ	8XZJ_refined	3.0	APJ	apelin	Apelin	A (Rhodopsin)	Human	-	scFv16	-	WN353	peptide	Agonist	apelin-13, apelin-36, apelin-17, Elabela/Toddler-21, Elabela/Toddler-32, Elabela/Toddler-11, apelin receptor early endogenous ligand, [Pyr¹]apelin-13	peptide	Wang WW, Ji SY, Zhang W, Zhang J, Cai C, Hu R, Zang SK, Miao L, Xu H, Chen LN, Yang Z, Guo J, Qin J, Shen DD, Liang P, Zhang Y, Zhang Y	10.1016/J.CELL.2024.02.004	2024-03-20	56200
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	8JXT	8JXT_refined	3.1	HRH4	H₄	Histamine	A (Rhodopsin)	Human	-	scFv16	-	histamine pubchem gtoplig chembl_ligand drug_central drugbank gtoplig pubchem	small-molecule	Agonist	histamine, CCL16	small-molecule	Xia R, Shi S, Xu Z, Vischer HF, Windhorst AD, Qian Y, Duan Y, Liang J, Chen K, Zhang A, Guo C, Leurs R, He Y	10.1038/S41467-024-46840-5	2024-03-20	56200
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	8JXX	8JXX_refined	3.1	HRH4	H₄	Histamine	A (Rhodopsin)	Human	-	scFv16	-	clobenpropit pubchem gtoplig chembl_ligand	small-molecule	Agonist	histamine, CCL16	small-molecule	Xia R, Shi S, Xu Z, Vischer HF, Windhorst AD, Qian Y, Duan Y, Liang J, Chen K, Zhang A, Guo C, Leurs R, He Y	10.1038/S41467-024-46840-5	2024-03-20	56200
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	8XZI	8XZI_refined	2.7	APJ	apelin	Apelin	A (Rhodopsin)	Human	-	-	-	CMF-019 pubchem gtoplig chembl_ligand	small-molecule	Agonist	apelin-13, apelin-36, apelin-17, Elabela/Toddler-21, Elabela/Toddler-32, Elabela/Toddler-11, apelin receptor early endogenous ligand, [Pyr¹]apelin-13	peptide	-	-	2024-03-20	56200
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	8XZH	8XZH_refined	2.6	APJ	apelin	Apelin	A (Rhodopsin)	Human	-	scFv16	-	MM07 pubchem gtoplig chembl_ligand	peptide	Agonist	apelin-13, apelin-36, apelin-17, Elabela/Toddler-21, Elabela/Toddler-32, Elabela/Toddler-11, apelin receptor early endogenous ligand, [Pyr¹]apelin-13	peptide	Wang WW, Ji SY, Zhang W, Zhang J, Cai C, Hu R, Zang SK, Miao L, Xu H, Chen LN, Yang Z, Guo J, Qin J, Shen DD, Liang P, Zhang Y, Zhang Y	10.1016/J.CELL.2024.02.004	2024-03-20	56200
Gi/o	αi1	Human	-	61	β1	Human	γ2	Human	Cryo-EM	8XZF	8XZF_refined	3.0	APJ	apelin	Apelin	A (Rhodopsin)	Human	-	scFv16	-	WN561	peptide	Agonist	apelin-13, apelin-36, apelin-17, Elabela/Toddler-21, Elabela/Toddler-32, Elabela/Toddler-11, apelin receptor early endogenous ligand, [Pyr¹]apelin-13	peptide	Wang WW, Ji SY, Zhang W, Zhang J, Cai C, Hu R, Zang SK, Miao L, Xu H, Chen LN, Yang Z, Guo J, Qin J, Shen DD, Liang P, Zhang Y, Zhang Y	10.1016/J.CELL.2024.02.004	2024-03-20	56200
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	8U4O	-	3.3	CXCR4	CXCR4	Chemokine	A (Rhodopsin)	Human	-	-	-	CXC12	protein	Agonist	CXCL12, CXCL12β, CXCL12α, CXCL12φ, CXCL12γ, CXCL12δ, CXCL12ε	peptide	Saotome K, McGoldrick LL, Ho JH, Ramlall TF, Shah S, Moore MJ, Kim JH, Leidich R, Olson WC, Franklin MC	10.1038/S41594-024-01397-1	2024-03-13	56200
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	8U4P	-	3.2	CXCR4	CXCR4	Chemokine	A (Rhodopsin)	Human	-	-	-	plerixafor pubchem gtoplig chembl_ligand drugbank drug_central pubchem	small-molecule	Agonist	CXCL12, CXCL12β, CXCL12α, CXCL12φ, CXCL12γ, CXCL12δ, CXCL12ε	peptide	Saotome K, McGoldrick LL, Ho JH, Ramlall TF, Shah S, Moore MJ, Kim JH, Leidich R, Olson WC, Franklin MC	10.1038/S41594-024-01397-1	2024-03-13	56200
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	8U4Q	-	3.4	CXCR4	CXCR4	Chemokine	A (Rhodopsin)	Human	-	REGN7663 Fab light chain	-	REGN7663 Fab heavy chain	protein	Agonist	CXCL12, CXCL12β, CXCL12α, CXCL12φ, CXCL12γ, CXCL12δ, CXCL12ε	peptide	Saotome K, McGoldrick LL, Ho JH, Ramlall TF, Shah S, Moore MJ, Kim JH, Leidich R, Olson WC, Franklin MC	10.1038/S41594-024-01397-1	2024-03-13	56200
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	8U4N	8U4N_refined	2.7	CXCR4	CXCR4	Chemokine	A (Rhodopsin)	Human	-	-	-	Apo (no ligand)	none	Apo (no ligand)	CXCL12, CXCL12β, CXCL12α, CXCL12φ, CXCL12γ, CXCL12δ, CXCL12ε	peptide	Saotome K, McGoldrick LL, Ho JH, Ramlall TF, Shah S, Moore MJ, Kim JH, Leidich R, Olson WC, Franklin MC	10.1038/S41594-024-01397-1	2024-03-13	56200
Gi/o	αo	Human	-	57	β1	Human	γ2	Human	Cryo-EM	8IYW	8IYW_refined	3.5	HCAR2	HCA₂	Hydroxycarboxylic acid	A (Rhodopsin)	Human	-	scFv16	-	GSK256073 pubchem gtoplig chembl_ligand	small-molecule	Agonist	butyric acid, β-D-hydroxybutyric acid	small-molecule	Yadav MK, Sarma P, Maharana J, Ganguly M, Mishra S, Zaidi N, Dalal A, Singh V, Saha S, Mahajan G, Sharma S, Chami M, Banerjee R, Shukla AK	10.1038/S41467-024-46239-2	2024-03-06	56206
Gi/o	αo	Human	-	58	β1	Human	γ2	Human	Cryo-EM	8JHN	8JHN_refined	3.8	HCAR2	HCA₂	Hydroxycarboxylic acid	A (Rhodopsin)	Human	-	scFv16	-	monomethyl fumarate pubchem gtoplig chembl_ligand drugbank	small-molecule	Agonist	butyric acid, β-D-hydroxybutyric acid	small-molecule	Yadav MK, Sarma P, Maharana J, Ganguly M, Mishra S, Zaidi N, Dalal A, Singh V, Saha S, Mahajan G, Sharma S, Chami M, Banerjee R, Shukla AK	10.1038/S41467-024-46239-2	2024-03-06	56206
Gi/o	αo	Human	-	58	β1	Human	γ2	Human	Cryo-EM	8JER	8JER_refined	3.5	HCAR2	HCA₂	Hydroxycarboxylic acid	A (Rhodopsin)	Human	-	scFv16	-	5-Methyl-4-oxidanyl-pyrazin-4-ium-2-carboxylic acid pubchem	small-molecule	Agonist	butyric acid, β-D-hydroxybutyric acid	small-molecule	Yadav MK, Sarma P, Maharana J, Ganguly M, Mishra S, Zaidi N, Dalal A, Singh V, Saha S, Mahajan G, Sharma S, Chami M, Banerjee R, Shukla AK	10.1038/S41467-024-46239-2	2024-03-06	56206
Gi/o	αo	Human	-	58	β1	Human	γ2	Human	Cryo-EM	8IYH	8IYH_refined	3.3	HCAR2	HCA₂	Hydroxycarboxylic acid	A (Rhodopsin)	Human	-	scFv16	-	MK 6892 pubchem gtoplig chembl_ligand pubchem	small-molecule	Agonist	butyric acid, β-D-hydroxybutyric acid	small-molecule	Yadav MK, Sarma P, Maharana J, Ganguly M, Mishra S, Zaidi N, Dalal A, Singh V, Saha S, Mahajan G, Sharma S, Chami M, Banerjee R, Shukla AK	10.1038/S41467-024-46239-2	2024-03-06	56206
Gi/o	αo	Human	-	59	β1	Human	γ2	Human	Cryo-EM	8IY9	8IY9_refined	3.4	HCAR2	HCA₂	Hydroxycarboxylic acid	A (Rhodopsin)	Human	-	scFv16	-	nicotinic acid pubchem gtoplig chembl_ligand drugbank drug_central gtoplig pubchem	small-molecule	Agonist	butyric acid, β-D-hydroxybutyric acid	small-molecule	Yadav MK, Sarma P, Maharana J, Ganguly M, Mishra S, Zaidi N, Dalal A, Singh V, Saha S, Mahajan G, Sharma S, Chami M, Banerjee R, Shukla AK	10.1038/S41467-024-46239-2	2024-03-06	56206
Gs	αs	Human	-	59	β1	Human	γ2	Human	Cryo-EM	8GFX	-	3.0	ADRB2	β₂	Adrenoceptors	A (Rhodopsin)	Human	-	-	-	(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol pubchem	small-molecule	Agonist	Zn²⁺, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline	small-molecule	Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G	10.1038/S41586-024-07153-1	2024-03-06	56198
Gs	αs	Human	-	71	β1	Human	γ2	Human	Cryo-EM	8GEF	8GEF_refined	3.8	ADRB2	β₂	Adrenoceptors	A (Rhodopsin)	Human	-	-	-	(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol pubchem	small-molecule	Agonist	Zn²⁺, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline	small-molecule	Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G	10.1038/S41586-024-07153-1	2024-03-06	56198
Gs	αs	Human	-	59	β1	Human	γ2	Human	Cryo-EM	8WA3	8WA3_refined	2.9	GIPR	GIP	Glucagon	B1 (Secretin)	Human	-	Nanobody-35	-	Apo (no ligand)	none	Apo (no ligand)	gastric inhibitory polypeptide	peptide	Cong Z, Zhao F, Li Y, Luo G, Mai Y, Chen X, Chen Y, Lin S, Cai X, Zhou Q, Yang D, Wang MW	10.1038/S41421-024-00649-0	2024-03-06	56198
Gs	αs	Human	-	59	β1	Human	γ2	Human	Cryo-EM	8GEB	8GEB_refined	3.6	ADRB2	β₂	Adrenoceptors	A (Rhodopsin)	Human	-	-	-	(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol pubchem	small-molecule	Agonist	Zn²⁺, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline	small-molecule	Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G	10.1038/S41586-024-07153-1	2024-03-06	56198
Gs	αs	Human	-	83	β1	Human	γ2	Human	Cryo-EM	8GGA	8GGA_refined	3.5	ADRB2	β₂	Adrenoceptors	A (Rhodopsin)	Human	-	-	-	(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol pubchem	small-molecule	Agonist	Zn²⁺, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline	small-molecule	Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G	10.1038/S41586-024-07153-1	2024-03-06	56198
Gs	αs	Human	GTP bound, Class P	58	β1	Human	γ2	Human	Cryo-EM	8UO0	-	3.5	ADRB2	β₂	Adrenoceptors	A (Rhodopsin)	Human	-	-	-	(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol pubchem	small-molecule	Agonist	Zn²⁺, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline	small-molecule	Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G	10.1038/S41586-024-07153-1	2024-03-06	56198
Gs	αs	Human	-	58	β1	Human	γ2	Human	Cryo-EM	8GE7	8GE7_refined	3.4	ADRB2	β₂	Adrenoceptors	A (Rhodopsin)	Human	-	-	-	(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol pubchem	small-molecule	Agonist	Zn²⁺, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline	small-molecule	Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G	10.1038/S41586-024-07153-1	2024-03-06	56198
Gs	αs	Human	-	76	β1	Human	γ2	Human	Cryo-EM	8GG9	8GG9_refined	3.4	ADRB2	β₂	Adrenoceptors	A (Rhodopsin)	Human	-	-	-	(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol pubchem	small-molecule	Agonist	Zn²⁺, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline	small-molecule	Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G	10.1038/S41586-024-07153-1	2024-03-06	56198
Gs	αs	Human	-	59	β1	Human	γ2	Human	Cryo-EM	8GFV	-	3.1	ADRB2	β₂	Adrenoceptors	A (Rhodopsin)	Human	-	-	-	(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol pubchem	small-molecule	Agonist	Zn²⁺, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline	small-molecule	Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G	10.1038/S41586-024-07153-1	2024-03-06	56198
Gs	αs	Human	GTP bound, Class O	57	β1	Human	γ2	Human	Cryo-EM	8UNZ	8UNZ_refined	3.8	ADRB2	β₂	Adrenoceptors	A (Rhodopsin)	Human	-	-	-	(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol pubchem	small-molecule	Agonist	Zn²⁺, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline	small-molecule	Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G	10.1038/S41586-024-07153-1	2024-03-06	56198
Gs	αs	Human	-	78	β1	Human	γ2	Human	Cryo-EM	8GEG	8GEG_refined	3.8	ADRB2	β₂	Adrenoceptors	A (Rhodopsin)	Human	-	-	-	(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol pubchem	small-molecule	Agonist	Zn²⁺, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline	small-molecule	Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G	10.1038/S41586-024-07153-1	2024-03-06	56198
Gs	αs	Human	GTP bound, Class N	60	β1	Human	γ2	Human	Cryo-EM	8UNY	-	3.6	ADRB2	β₂	Adrenoceptors	A (Rhodopsin)	Human	-	-	-	(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol pubchem	small-molecule	Agonist	Zn²⁺, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline	small-molecule	Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G	10.1038/S41586-024-07153-1	2024-03-06	56198
Gs	αs	Human	-	59	β1	Human	γ2	Human	Cryo-EM	8GE6	8GE6_refined	3.4	ADRB2	β₂	Adrenoceptors	A (Rhodopsin)	Human	-	-	-	(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol pubchem	small-molecule	Agonist	Zn²⁺, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline	small-molecule	Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G	10.1038/S41586-024-07153-1	2024-03-06	56198
Gs	αs	Human	-	59	β1	Human	γ2	Human	Cryo-EM	8GE4	-	3.3	ADRB2	β₂	Adrenoceptors	A (Rhodopsin)	Human	-	-	-	(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol pubchem	small-molecule	Agonist	Zn²⁺, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline	small-molecule	Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G	10.1038/S41586-024-07153-1	2024-03-06	56198
Gs	αs	Human	-	61	β1	Human	γ2	Human	Cryo-EM	8GG8	-	3.3	ADRB2	β₂	Adrenoceptors	A (Rhodopsin)	Human	-	-	-	(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol pubchem	small-molecule	Agonist	Zn²⁺, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline	small-molecule	Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G	10.1038/S41586-024-07153-1	2024-03-06	56198
Gs	αs	Human	GTP bound, Class A	59	β1	Human	γ2	Human	Cryo-EM	8UNL	-	3.3	ADRB2	β₂	Adrenoceptors	A (Rhodopsin)	Human	-	-	-	(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol pubchem	small-molecule	Agonist	Zn²⁺, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline	small-molecule	Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G	10.1038/S41586-024-07153-1	2024-03-06	56198
Gs	αs	Human	-	91	β1	Human	γ2	Human	Cryo-EM	8GGF	8GGF_refined	3.6	ADRB2	β₂	Adrenoceptors	A (Rhodopsin)	Human	-	-	-	(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol pubchem	small-molecule	Agonist	Zn²⁺, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline	small-molecule	Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G	10.1038/S41586-024-07153-1	2024-03-06	56198
Gs	αs	Human	-	69	β1	Human	γ2	Human	Cryo-EM	8GEE	8GEE_refined	3.7	ADRB2	β₂	Adrenoceptors	A (Rhodopsin)	Human	-	-	-	(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol pubchem	small-molecule	Agonist	Zn²⁺, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline	small-molecule	Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G	10.1038/S41586-024-07153-1	2024-03-06	56198
Gs	αs	Human	GTP bound, Class D	57	β1	Human	γ2	Human	Cryo-EM	8UNO	-	3.3	ADRB2	β₂	Adrenoceptors	A (Rhodopsin)	Human	-	-	-	(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol pubchem	small-molecule	Agonist	Zn²⁺, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline	small-molecule	Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G	10.1038/S41586-024-07153-1	2024-03-06	56198
Gs	αs	Human	-	76	β1	Human	γ2	Human	Cryo-EM	8GEH	8GEH_refined	4.0	ADRB2	β₂	Adrenoceptors	A (Rhodopsin)	Human	-	-	-	(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol pubchem	small-molecule	Agonist	Zn²⁺, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline	small-molecule	Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G	10.1038/S41586-024-07153-1	2024-03-06	56198
Gs	αs	Human	GTP bound, Class S	91	β1	Human	γ2	Human	Cryo-EM	8UO3	8UO3_refined	3.5	ADRB2	β₂	Adrenoceptors	A (Rhodopsin)	Human	-	-	-	(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol pubchem	small-molecule	Agonist	Zn²⁺, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline	small-molecule	Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G	10.1038/S41586-024-07153-1	2024-03-06	56198
Gs	αs	Human	-	59	β1	Human	γ2	Human	Cryo-EM	8GG1	-	3.0	ADRB2	β₂	Adrenoceptors	A (Rhodopsin)	Human	-	-	-	(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol pubchem	small-molecule	Agonist	Zn²⁺, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline	small-molecule	Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G	10.1038/S41586-024-07153-1	2024-03-06	56198
Gs	αs	Human	GTP bound, Class R	72	β1	Human	γ2	Human	Cryo-EM	8UO2	8UO2_refined	3.6	ADRB2	β₂	Adrenoceptors	A (Rhodopsin)	Human	-	-	-	(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol pubchem	small-molecule	Agonist	Zn²⁺, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline	small-molecule	Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G	10.1038/S41586-024-07153-1	2024-03-06	56198
Gs	αs	Human	-	60	β1	Human	γ2	Human	Cryo-EM	8X7A	8X7A_refined	2.6	PI2R	IP	Prostanoid	A (Rhodopsin)	Human	-	Nanobody-35	-	treprostinil pubchem gtoplig chembl_ligand drugbank drug_central pubchem	small-molecule	Agonist	PGE₁, PGF_2α, PGI₂, PGE₂, thromboxane A₂, PGD₂	small-molecule	Wang JJ, Jin S, Zhang H, Xu Y, Hu W, Jiang Y, Chen C, Wang DW, Xu HE, Wu C	10.1126/SCIADV.ADK5184	2024-03-06	56198
Gs	αs	Human	GTP bound, Class M	62	β1	Human	γ2	Human	Cryo-EM	8UNX	-	3.6	ADRB2	β₂	Adrenoceptors	A (Rhodopsin)	Human	-	-	-	(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol pubchem	small-molecule	Agonist	Zn²⁺, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline	small-molecule	Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G	10.1038/S41586-024-07153-1	2024-03-06	56198
Gs	αs	Human	-	59	β1	Human	γ2	Human	Cryo-EM	8GE1	-	3.4	ADRB2	β₂	Adrenoceptors	A (Rhodopsin)	Human	-	-	-	(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol pubchem	small-molecule	Agonist	Zn²⁺, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline	small-molecule	Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G	10.1038/S41586-024-07153-1	2024-03-06	56198
Gs	αs	Human	-	59	β1	Human	γ2	Human	Cryo-EM	8GG2	-	3.0	ADRB2	β₂	Adrenoceptors	A (Rhodopsin)	Human	-	-	-	(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol pubchem	small-molecule	Agonist	Zn²⁺, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline	small-molecule	Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G	10.1038/S41586-024-07153-1	2024-03-06	56198
Gs	αs	Human	GTP bound, Class E	60	β1	Human	γ2	Human	Cryo-EM	8UNP	-	3.3	ADRB2	β₂	Adrenoceptors	A (Rhodopsin)	Human	-	-	-	(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol pubchem	small-molecule	Agonist	Zn²⁺, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline	small-molecule	Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G	10.1038/S41586-024-07153-1	2024-03-06	56198
Gs	αs	Human	-	59	β1	Human	γ2	Human	Cryo-EM	8WG7	8WG7_refined	2.5	GLP1R	GLP-1	Glucagon	B1 (Secretin)	Human	-	Nanobody-35	-	Apo (no ligand)	none	Apo (no ligand)	glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37)	peptide	Cong Z, Zhao F, Li Y, Luo G, Mai Y, Chen X, Chen Y, Lin S, Cai X, Zhou Q, Yang D, Wang MW	10.1038/S41421-024-00649-0	2024-03-06	56198
Gs	αs	Human	-	58	β1	Human	γ2	Human	Cryo-EM	8GFZ	-	3.0	ADRB2	β₂	Adrenoceptors	A (Rhodopsin)	Human	-	-	-	(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol pubchem	small-molecule	Agonist	Zn²⁺, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline	small-molecule	Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G	10.1038/S41586-024-07153-1	2024-03-06	56198
Gs	αs	Human	GTP bound, Class I	60	β1	Human	γ2	Human	Cryo-EM	8UNT	-	3.4	ADRB2	β₂	Adrenoceptors	A (Rhodopsin)	Human	-	-	-	(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol pubchem	small-molecule	Agonist	Zn²⁺, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline	small-molecule	Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G	10.1038/S41586-024-07153-1	2024-03-06	56198
Gs	αs	Human	-	60	β1	Human	γ2	Human	Cryo-EM	8GE3	-	3.3	ADRB2	β₂	Adrenoceptors	A (Rhodopsin)	Human	-	-	-	(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol pubchem	small-molecule	Agonist	Zn²⁺, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline	small-molecule	Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G	10.1038/S41586-024-07153-1	2024-03-06	56198
Gs	αs	Human	-	60	β1	Human	γ2	Human	Cryo-EM	8GG5	-	3.2	ADRB2	β₂	Adrenoceptors	A (Rhodopsin)	Human	-	-	-	(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol pubchem	small-molecule	Agonist	Zn²⁺, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline	small-molecule	Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G	10.1038/S41586-024-07153-1	2024-03-06	56198
Gs	αs	Human	GTP bound, Class C	59	β1	Human	γ2	Human	Cryo-EM	8UNN	-	3.4	ADRB2	β₂	Adrenoceptors	A (Rhodopsin)	Human	-	-	-	(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol pubchem	small-molecule	Agonist	Zn²⁺, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline	small-molecule	Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G	10.1038/S41586-024-07153-1	2024-03-06	56198
Gs	αs	Human	-	58	β1	Human	γ2	Human	Cryo-EM	8GFY	-	3.0	ADRB2	β₂	Adrenoceptors	A (Rhodopsin)	Human	-	-	-	(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol pubchem	small-molecule	Agonist	Zn²⁺, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline	small-molecule	Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G	10.1038/S41586-024-07153-1	2024-03-06	56198
Gs	αs	Human	GTP bound, Class F	61	β1	Human	γ2	Human	Cryo-EM	8UNQ	-	3.3	ADRB2	β₂	Adrenoceptors	A (Rhodopsin)	Human	-	-	-	(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol pubchem	small-molecule	Agonist	Zn²⁺, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline	small-molecule	Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G	10.1038/S41586-024-07153-1	2024-03-06	56198
Gs	αs	Human	GTP bound, Class T	74	β1	Human	γ2	Human	Cryo-EM	8UO4	8UO4_refined	4.0	ADRB2	β₂	Adrenoceptors	A (Rhodopsin)	Human	-	-	-	(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol pubchem	small-molecule	Agonist	Zn²⁺, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline	small-molecule	Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G	10.1038/S41586-024-07153-1	2024-03-06	56198
Gs	αs	Human	-	79	β1	Human	γ2	Human	Cryo-EM	8GEJ	8GEJ_refined	4.2	ADRB2	β₂	Adrenoceptors	A (Rhodopsin)	Human	-	-	-	(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol pubchem	small-molecule	Agonist	Zn²⁺, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline	small-molecule	Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G	10.1038/S41586-024-07153-1	2024-03-06	56198
Gs	αs	Human	-	56	β1	Human	γ2	Human	Cryo-EM	8POK	8POK_refined	3.4	HRH2	H₂	Histamine	A (Rhodopsin)	Human	-	Nanobody-35	-	histamine pubchem gtoplig chembl_ligand drug_central drugbank gtoplig pubchem	small-molecule	Agonist	histamine	small-molecule	Kock Z, Schnelle K, Persechino M, Umbach S, Schihada H, Januliene D, Parey K, Pockes S, Kolb P, Dotsch V, Moller A, Hilger D, Bernhard F	10.1038/S41467-024-46096-Z	2024-03-06	56198
Gs	αs	Human	GTP bound, Class L	59	β1	Human	γ2	Human	Cryo-EM	8UNW	-	3.4	ADRB2	β₂	Adrenoceptors	A (Rhodopsin)	Human	-	-	-	(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol pubchem	small-molecule	Agonist	Zn²⁺, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline	small-molecule	Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G	10.1038/S41586-024-07153-1	2024-03-06	56198
Gs	αs	Human	-	59	β1	Human	γ2	Human	Cryo-EM	8GDZ	-	3.5	ADRB2	β₂	Adrenoceptors	A (Rhodopsin)	Human	-	-	-	(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol pubchem	small-molecule	Agonist	Zn²⁺, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline	small-molecule	Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G	10.1038/S41586-024-07153-1	2024-03-06	56198
Gs	αs	Human	-	59	β1	Human	γ2	Human	Cryo-EM	8GG0	-	2.9	ADRB2	β₂	Adrenoceptors	A (Rhodopsin)	Human	-	-	-	(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol pubchem	small-molecule	Agonist	Zn²⁺, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline	small-molecule	Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G	10.1038/S41586-024-07153-1	2024-03-06	56198
Gs	αs	Human	-	59	β1	Human	γ2	Human	Cryo-EM	8GE2	-	3.3	ADRB2	β₂	Adrenoceptors	A (Rhodopsin)	Human	-	-	-	(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol pubchem	small-molecule	Agonist	Zn²⁺, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline	small-molecule	Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G	10.1038/S41586-024-07153-1	2024-03-06	56198
Gs	αs	Human	-	59	β1	Human	γ2	Human	Cryo-EM	8GG4	-	3.2	ADRB2	β₂	Adrenoceptors	A (Rhodopsin)	Human	-	-	-	(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol pubchem	small-molecule	Agonist	Zn²⁺, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline	small-molecule	Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G	10.1038/S41586-024-07153-1	2024-03-06	56198
Gs	αs	Human	-	70	β1	Human	γ2	Human	Cryo-EM	8GEI	-	4.1	ADRB2	β₂	Adrenoceptors	A (Rhodopsin)	Human	-	-	-	(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol pubchem	small-molecule	Agonist	Zn²⁺, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline	small-molecule	Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G	10.1038/S41586-024-07153-1	2024-03-06	56198
Gs	αs	Human	-	59	β1	Human	γ2	Human	Cryo-EM	8U8F	8U8F_refined	3.5	GPR3	GPR3	A orphans	A (Rhodopsin)	Human	-	-	-	palmitic acid pubchem gtoplig chembl_ligand drugbank pubchem	small-molecule	Agonist	sphingosine 1-phosphate	small-molecule	Russell IC, Zhang X, Bumbak F, McNeill SM, Josephs TM, Leeming MG, Christopoulos G, Venugopal H, Flocco MM, Sexton PM, Wootten D, Belousoff MJ	10.1021/ACS.BIOCHEM.3C00647	2024-03-06	56198
Gs	αs	Human	GTP bound, Class J	57	β1	Human	γ2	Human	Cryo-EM	8UNU	-	3.5	ADRB2	β₂	Adrenoceptors	A (Rhodopsin)	Human	-	-	-	(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol pubchem	small-molecule	Agonist	Zn²⁺, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline	small-molecule	Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G	10.1038/S41586-024-07153-1	2024-03-06	56198
Gs	αs	Human	-	71	β1	Human	γ2	Human	Cryo-EM	8GED	8GED_refined	3.5	ADRB2	β₂	Adrenoceptors	A (Rhodopsin)	Human	-	-	-	(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol pubchem	small-molecule	Agonist	Zn²⁺, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline	small-molecule	Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G	10.1038/S41586-024-07153-1	2024-03-06	56198
Gs	αs	Human	-	59	β1	Human	γ2	Human	Cryo-EM	8WG8	8WG8_refined	2.7	GLR	glucagon	Glucagon	B1 (Secretin)	Human	-	Nanobody-35	-	Apo (no ligand)	none	Apo (no ligand)	glucagon	peptide	Cong Z, Zhao F, Li Y, Luo G, Mai Y, Chen X, Chen Y, Lin S, Cai X, Zhou Q, Yang D, Wang MW	10.1038/S41421-024-00649-0	2024-03-06	56198
Gs	αs	Human	-	59	β1	Human	γ2	Human	Cryo-EM	8GFW	-	3.0	ADRB2	β₂	Adrenoceptors	A (Rhodopsin)	Human	-	-	-	(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol pubchem	small-molecule	Agonist	Zn²⁺, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline	small-molecule	Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G	10.1038/S41586-024-07153-1	2024-03-06	56198
Gs	αs	Human	GTP bound, Class H	61	β1	Human	γ2	Human	Cryo-EM	8UNS	-	3.4	ADRB2	β₂	Adrenoceptors	A (Rhodopsin)	Human	-	-	-	(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol pubchem	small-molecule	Agonist	Zn²⁺, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline	small-molecule	Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G	10.1038/S41586-024-07153-1	2024-03-06	56198
Gs	αs	Human	-	60	β1	Human	γ2	Human	Cryo-EM	8GE9	8GE9_refined	3.5	ADRB2	β₂	Adrenoceptors	A (Rhodopsin)	Human	-	-	-	(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol pubchem	small-molecule	Agonist	Zn²⁺, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline	small-molecule	Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G	10.1038/S41586-024-07153-1	2024-03-06	56198
Gs	αs	Human	-	75	β1	Human	γ2	Human	Cryo-EM	8GGC	-	3.4	ADRB2	β₂	Adrenoceptors	A (Rhodopsin)	Human	-	-	-	(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol pubchem	small-molecule	Agonist	Zn²⁺, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline	small-molecule	Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G	10.1038/S41586-024-07153-1	2024-03-06	56198
Gs	αs	Human	-	59	β1	Human	γ2	Human	Cryo-EM	8GEC	8GEC_refined	3.5	ADRB2	β₂	Adrenoceptors	A (Rhodopsin)	Human	-	-	-	(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol pubchem	small-molecule	Agonist	Zn²⁺, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline	small-molecule	Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G	10.1038/S41586-024-07153-1	2024-03-06	56198
Gs	αs	Human	-	60	β1	Human	γ2	Human	Cryo-EM	8GE8	8GE8_refined	3.4	ADRB2	β₂	Adrenoceptors	A (Rhodopsin)	Human	-	-	-	(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol pubchem	small-molecule	Agonist	Zn²⁺, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline	small-molecule	Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G	10.1038/S41586-024-07153-1	2024-03-06	56198
Gs	αs	Human	-	79	β1	Human	γ2	Human	Cryo-EM	8GGB	8GGB_refined	3.5	ADRB2	β₂	Adrenoceptors	A (Rhodopsin)	Human	-	-	-	(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol pubchem	small-molecule	Agonist	Zn²⁺, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline	small-molecule	Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G	10.1038/S41586-024-07153-1	2024-03-06	56198
Gs	αs	Human	GTP bound, Class B	57	β1	Human	γ2	Human	Cryo-EM	8UNM	-	3.4	ADRB2	β₂	Adrenoceptors	A (Rhodopsin)	Human	-	-	-	(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol pubchem	small-molecule	Agonist	Zn²⁺, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline	small-molecule	Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G	10.1038/S41586-024-07153-1	2024-03-06	56198
Gs	αs	Human	-	61	β1	Human	γ2	Human	Cryo-EM	8GEA	8GEA_refined	3.5	ADRB2	β₂	Adrenoceptors	A (Rhodopsin)	Human	-	-	-	(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol pubchem	small-molecule	Agonist	Zn²⁺, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline	small-molecule	Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G	10.1038/S41586-024-07153-1	2024-03-06	56198
Gs	αs	Human	-	92	β1	Human	γ2	Human	Cryo-EM	8GGE	8GGE_refined	3.5	ADRB2	β₂	Adrenoceptors	A (Rhodopsin)	Human	-	-	-	(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol pubchem	small-molecule	Agonist	Zn²⁺, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline	small-molecule	Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G	10.1038/S41586-024-07153-1	2024-03-06	56198
Gs	αs	Human	GTP bound, Class Q	85	β1	Human	γ2	Human	Cryo-EM	8UO1	8UO1_refined	3.6	ADRB2	β₂	Adrenoceptors	A (Rhodopsin)	Human	-	-	-	(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol pubchem	small-molecule	Agonist	Zn²⁺, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline	small-molecule	Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G	10.1038/S41586-024-07153-1	2024-03-06	56198
Gs	αs	Human	-	59	β1	Human	γ2	Human	Cryo-EM	8X79	8X79_refined	2.4	PI2R	IP	Prostanoid	A (Rhodopsin)	Human	-	Nanobody-35	-	MRE-269 pubchem gtoplig chembl_ligand	small-molecule	Agonist	PGE₁, PGF_2α, PGI₂, PGE₂, thromboxane A₂, PGD₂	small-molecule	Wang JJ, Jin S, Zhang H, Xu Y, Hu W, Jiang Y, Chen C, Wang DW, Xu HE, Wu C	10.1126/SCIADV.ADK5184	2024-03-06	56198
Gs	αs	Human	-	59	β1	Human	γ2	Human	Cryo-EM	8GG3	-	3.1	ADRB2	β₂	Adrenoceptors	A (Rhodopsin)	Human	-	-	-	(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol pubchem	small-molecule	Agonist	Zn²⁺, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline	small-molecule	Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G	10.1038/S41586-024-07153-1	2024-03-06	56198
Gs	αs	Human	GTP bound, Class G	61	β1	Human	γ2	Human	Cryo-EM	8UNR	-	3.4	ADRB2	β₂	Adrenoceptors	A (Rhodopsin)	Human	-	-	-	(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol pubchem	small-molecule	Agonist	Zn²⁺, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline	small-molecule	Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G	10.1038/S41586-024-07153-1	2024-03-06	56198
Gs	αs	Human	GTP bound, Class K	59	β1	Human	γ2	Human	Cryo-EM	8UNV	-	3.3	ADRB2	β₂	Adrenoceptors	A (Rhodopsin)	Human	-	-	-	(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol pubchem	small-molecule	Agonist	Zn²⁺, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline	small-molecule	Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G	10.1038/S41586-024-07153-1	2024-03-06	56198
Gs	αs	Human	-	59	β1	Human	γ2	Human	Cryo-EM	8GE5	-	3.2	ADRB2	β₂	Adrenoceptors	A (Rhodopsin)	Human	-	-	-	(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol pubchem	small-molecule	Agonist	Zn²⁺, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline	small-molecule	Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G	10.1038/S41586-024-07153-1	2024-03-06	56198
Gs	αs	Human	-	60	β1	Human	γ2	Human	Cryo-EM	8GG6	-	3.3	ADRB2	β₂	Adrenoceptors	A (Rhodopsin)	Human	-	-	-	(5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol pubchem	small-molecule	Agonist	Zn²⁺, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline	small-molecule	Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G	10.1038/S41586-024-07153-1	2024-03-06	56198
Gs	αs2	Human	-	96	β1	Human	γ2	Human	Cryo-EM	8GG7	-	3.3	-	-	-	-	-	-	-	Beta-2 adrenergic receptor	-	-	-	-	-	Papasergi-Scott MM, Perez-Hernandez G, Batebi H, Gao Y, Eskici G, Seven AB, Panova O, Hilger D, Casiraghi M, He F, Maul L, Gmeiner P, Kobilka BK, Hildebrand PW, Skiniotis G	38480881	2024-03-06	56198
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	8GAG	8GAG_refined	3.3	CNR1	CB₁	Cannabinoid	A (Rhodopsin)	Human	-	scFv16	-	methyl (2R)-2-({(1M)-5-methyl-1-[3-(trifluoromethyl)phenyl]-1H-pyrazole-3-carbonyl}amino)-2-(thiophen-2-yl)propanoate pubchem	small-molecule	Agonist	2-arachidonoylglycerol, anandamide	small-molecule	-	-	2024-02-28	56200
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	8JT6	-	3.0	5HT1A	5-HT_1A	5-Hydroxytryptamine	A (Rhodopsin)	Human	BRIL	scFv16	-	1-(4-fluorophenyl)-4-[(7R)-2,5,11-triazatetracyclo[7.6.1.0^2,7.0^12,16]hexadeca-1(15),9,12(16),13-tetraen-5-yl]butan-1-one pubchem	small-molecule	Agonist	5-hydroxytryptamine	small-molecule	Chen Z, Yu J, Wang H, Xu P, Fan L, Sun F, Huang S, Zhang P, Huang H, Gu S, Zhang B, Zhou Y, Wan X, Pei G, Xu HE, Cheng J, Wang S	10.1016/J.CELL.2024.02.034	2024-02-28	56200
Gq/11	αq	Human	-	58	β1	Human	γ2	Human	Cryo-EM	8XJM	8XJM_refined	2.9	PF2R	FP	Prostanoid	A (Rhodopsin)	Human	-	scFv16	-	latanoprost (free acid form) pubchem gtoplig chembl_ligand	small-molecule	Agonist	PGF_2α, PGI₂, PGE₂, thromboxane A₂, PGD₂	small-molecule	Li X, Zhang X, Wen X, Zhang D, Qu C, Miao X, Zhang W, Zhang R, Liu G, Xiao P, Sun JP, Gong W	10.1016/J.CELREP.2024.113893	2024-02-28	56208
Gq/11	αq	Human	-	58	β1	Human	γ2	Human	Cryo-EM	8XJL	8XJL_refined	2.8	PF2R	FP	Prostanoid	A (Rhodopsin)	Human	-	scFv16	-	PGF_2α pubchem gtoplig chembl_ligand drug_central drugbank	small-molecule	Agonist	PGF_2α, PGI₂, PGE₂, thromboxane A₂, PGD₂	small-molecule	Li X, Zhang X, Wen X, Zhang D, Qu C, Miao X, Zhang W, Zhang R, Liu G, Xiao P, Sun JP, Gong W	10.1016/J.CELREP.2024.113893	2024-02-28	56208
Gq/11	αq	Human	-	58	β1	Human	γ2	Human	Cryo-EM	8XJO	8XJO_refined	3.1	TA2R	TP	Prostanoid	A (Rhodopsin)	Human	-	scFv16	-	U46619 pubchem gtoplig chembl_ligand gtoplig	small-molecule	Agonist	PGF_2α, PGH₂, PGI₂, PGE₂, thromboxane A₂, PGD₂	small-molecule	Li X, Zhang X, Wen X, Zhang D, Qu C, Miao X, Zhang W, Zhang R, Liu G, Xiao P, Sun JP, Gong W	10.1016/J.CELREP.2024.113893	2024-02-28	56208
Gq/11	αq	Human	-	59	β1	Rat	γ2	Bovine	Cryo-EM	8JBF	-	3.0	NK3R	NK₃	Tachykinin	A (Rhodopsin)	Human	-	scFv16	-	senktide pubchem gtoplig chembl_ligand	peptide	Agonist	neurokinin A, neurokinin B, substance P	peptide	Sun W, Yang F, Zhang H, Yuan Q, Ling S, Wang Y, Lv P, Li Z, Luo Y, Liu D, Yin W, Shi P, Xu HE, Tian C	10.1038/S41421-023-00564-W	2024-02-28	56208
Gq/11	αq	Human	-	58	β1	Human	γ2	Human	Cryo-EM	8XJN	8XJN_refined	3.1	TA2R	TP	Prostanoid	A (Rhodopsin)	Human	-	scFv16	-	cloprostenol pubchem gtoplig chembl_ligand drugbank	small-molecule	Agonist	PGF_2α, PGH₂, PGI₂, PGE₂, thromboxane A₂, PGD₂	small-molecule	-	-	2024-02-28	56208
Gq/11	αq	Human	-	58	β1	Human	γ2	Human	Cryo-EM	8XJK	8XJK_refined	2.6	PF2R	FP	Prostanoid	A (Rhodopsin)	Human	-	scFv16	-	cloprostenol pubchem gtoplig chembl_ligand drugbank	small-molecule	Agonist	PGF_2α, PGI₂, PGE₂, thromboxane A₂, PGD₂	small-molecule	-	-	2024-02-28	56208
Gs	αs	Human	-	61	β1	Human	γ2	Human	Cryo-EM	8SMV	8SMV_refined	2.7	GP161	GPR161	A orphans	A (Rhodopsin)	Human	-	Nanobody-35	-	Apo (no ligand)	none	Apo (no ligand)	-	-	Hoppe N, Harrison S, Hwang SH, Chen Z, Karelina M, Deshpande I, Suomivuori CM, Palicharla VR, Berry SP, Tschaikner P, Regele D, Covey DF, Stefan E, Marks DS, Reiter J, Dror RO, Evers AS, Mukhopadhyay S, Manglik A	10.1101/2023.05.23.540554	2024-02-21	56198
Gi/o	αo	Human	-	61	β1	Human	γ2	Human	Cryo-EM	8IED	-	3.3	GP156	GPR156	C Orphans	C (Glutamate)	Human	-	-	-	[(2R)-3-[(E)-hexadec-9-enoyl]oxy-2-octadecanoyloxypropyl] 2-(trimethylazaniumyl)ethyl phosphate pubchem	lipid	Agonist	-	-	-	-	2024-02-14	56206
Gi/o	αo	Human	-	64	β1	Human	γ2	Human	Cryo-EM	8IEC	-	3.2	-	-	-	-	-	-	Single-chain variable fragment scFv16	-	-	-	-	-	-	Shin J, Park J, Jeong J, Lam JH, Qiu X, Wu D, Kim K, Lee JY, Robinson CV, Hyun J, Katritch V, Kim KP, Cho Y	38332368	2024-02-14	56206
Gs	αs	Human	-	61	β1	Human	γ2	Human	Cryo-EM	8K8J	-	2.9	CNR1	CB₁	Cannabinoid	A (Rhodopsin)	Human	BRIL	Nanobody-35	-	FENOFIBRATE chembl_ligand pubchem	small-molecule	Agonist	2-arachidonoylglycerol, anandamide	small-molecule	Wang T, Tang W, Zhao Z, Zhao R, Lv Z, Guo X, Gu Q, Liu B, Lv H, Chen J, Zhang K, Li F, Wang J	10.1002/ADVS.202306311	2024-02-14	56198
Gs	αs	Human	-	58	β1	Human	γ2	Human	Cryo-EM	8WW2	-	2.8	GPR3	GPR3	A orphans	A (Rhodopsin)	Human	-	Nanobody-35	-	oleic acid pubchem gtoplig chembl_ligand drug_central	small-molecule	Agonist	sphingosine 1-phosphate	small-molecule	Xiong Y, Xu Z, Li X, Wang Y, Zhao J, Wang N, Duan Y, Xia R, Han Z, Qian Y, Liang J, Zhang A, Guo C, Inoue A, Xia Y, Chen Z, He Y	10.1038/S41422-024-00932-5	2024-02-14	56198
Gi/o	αi1	Human	-	64	β1	Human	γ2	Human	Cryo-EM	8KFX	8KFX_refined	3.0	CCR8	CCR8	Chemokine	A (Rhodopsin)	Human	-	scFv16	-	CHEMBL5268017 chembl_ligand pubchem	small-molecule	Agonist	CCL8, CCL1	peptide	Jiang S, Lin X, Wu L, Wang L, Wu Y, Xu Z, Xu F	10.1126/SCIADV.ADJ7500	2024-02-07	56200
Gi/o	αi1	Human	-	45	β1	Human	γ2	Human	Cryo-EM	8I7W	8I7W_refined	3.4	HCAR2	HCA₂	Hydroxycarboxylic acid	A (Rhodopsin)	Human	-	scFv16	-	GSK256073 pubchem gtoplig chembl_ligand	small-molecule	Agonist	butyric acid, β-D-hydroxybutyric acid	small-molecule	Park JH, Kawakami K, Ishimoto N, Ikuta T, Ohki M, Ekimoto T, Ikeguchi M, Lee DS, Lee YH, Tame JRH, Inoue A, Park SY	10.1038/S41467-023-42764-8	2024-02-07	56200
Gi/o	αi3	Human	-	63	β1	Human	γ2	Human	Cryo-EM	8SZH	-	3.1	CASR	CaS	Calcium-sensing	C (Glutamate)	Human	-	-	-	L-tryptophan pubchem gtoplig chembl_ligand drugbank drug_central pubchem cinacalcet pubchem gtoplig chembl_ligand drugbank drug_central pubchem	small-molecule small-molecule	Agonist PAM	Mg²⁺, L-tryptophan, spermine, Ca²⁺	small-molecule	He F, Wu CG, Gao Y, Rahman SN, Zaoralova M, Papasergi-Scott MM, Gu TJ, Robertson MJ, Seven AB, Li L, Mathiesen JM, Skiniotis G	10.1038/S41586-024-07055-2	2024-02-07	56202
Gi/o	αi1	Human	-	64	β1	Human	γ2	Human	Cryo-EM	8KFY	8KFY_refined	3.1	CCR8	CCR8	Chemokine	A (Rhodopsin)	Human	-	scFv16	-	ZK 756326 pubchem gtoplig chembl_ligand	small-molecule	Agonist	CCL8, CCL1	peptide	Jiang S, Lin X, Wu L, Wang L, Wu Y, Xu Z, Xu F	10.1126/SCIADV.ADJ7500	2024-02-07	56200
Gi/o	αi1	Human	-	41	β1	Human	γ2	Human	Cryo-EM	8I7V	-	2.8	HCAR2	HCA₂	Hydroxycarboxylic acid	A (Rhodopsin)	Human	-	scFv16	-	5-Methyl-4-oxidanyl-pyrazin-4-ium-2-carboxylic acid pubchem	small-molecule	Agonist	butyric acid, β-D-hydroxybutyric acid	small-molecule	Park JH, Kawakami K, Ishimoto N, Ikuta T, Ohki M, Ekimoto T, Ikeguchi M, Lee DS, Lee YH, Tame JRH, Inoue A, Park SY	10.1038/S41467-023-42764-8	2024-02-07	56200
Gi/o	αi3	Human	-	63	β1	Human	γ2	Human	Cryo-EM	8SZI	-	3.5	CASR	CaS	Calcium-sensing	C (Glutamate)	Human	-	-	-	L-tryptophan pubchem gtoplig chembl_ligand drugbank drug_central pubchem L-tryptophan pubchem gtoplig chembl_ligand drugbank drug_central pubchem	small-molecule small-molecule	Agonist PAM	Mg²⁺, L-tryptophan, spermine, Ca²⁺	small-molecule	He F, Wu CG, Gao Y, Rahman SN, Zaoralova M, Papasergi-Scott MM, Gu TJ, Robertson MJ, Seven AB, Li L, Mathiesen JM, Skiniotis G	10.1038/S41586-024-07055-2	2024-02-07	56202
Gi/o	αi1	Human	-	64	β1	Human	γ2	Human	Cryo-EM	8KFZ	8KFZ_refined	3.3	CCR8	CCR8	Chemokine	A (Rhodopsin)	Human	-	scFv16	-	Apo (no ligand)	none	Apo (no ligand)	CCL8, CCL1	peptide	Jiang S, Lin X, Wu L, Wang L, Wu Y, Xu Z, Xu F	10.1126/SCIADV.ADJ7500	2024-02-07	56200
Gq/11	αq	Human	-	61	β1	Human	γ2	Human	Cryo-EM	8SZG	-	3.6	CASR	CaS	Calcium-sensing	C (Glutamate)	Human	-	-	-	L-tryptophan pubchem gtoplig chembl_ligand drugbank drug_central pubchem cinacalcet pubchem gtoplig chembl_ligand drugbank drug_central pubchem	small-molecule small-molecule	Agonist PAM	Mg²⁺, L-tryptophan, spermine, Ca²⁺	small-molecule	He F, Wu CG, Gao Y, Rahman SN, Zaoralova M, Papasergi-Scott MM, Gu TJ, Robertson MJ, Seven AB, Li L, Mathiesen JM, Skiniotis G	10.1038/S41586-024-07055-2	2024-02-07	56208
Gq/11	αq	Human	-	59	β1	Rat	γ2	Bovine	Cryo-EM	8JBH	8JBH_refined	2.9	NK3R	NK₃	Tachykinin	A (Rhodopsin)	Human	-	scFv16	-	Protachykinin-1	peptide	Agonist	neurokinin A, neurokinin B, substance P	peptide	-	-	2024-02-07	56208
Gq/11	αq	Human	-	59	β1	Rat	γ2	Bovine	Cryo-EM	8JBG	8JBG_refined	2.8	NK3R	NK₃	Tachykinin	A (Rhodopsin)	Human	-	scFv16	-	neurokinin B pubchem gtoplig chembl_ligand	peptide	Agonist	neurokinin A, neurokinin B, substance P	peptide	-	-	2024-02-07	56208
Gs	αs	Human	-	51	β1	Human	γ2	Human	Cryo-EM	8IQ6	8IQ6_refined	3.4	PF2R	FP	Prostanoid	A (Rhodopsin)	Human	-	Nanobody-35	-	latanoprost (free acid form) pubchem gtoplig chembl_ligand	small-molecule	Agonist	PGF_2α, PGI₂, PGE₂, thromboxane A₂, PGD₂	small-molecule	Lv X, Gao K, Nie J, Zhang X, Zhang S, Ren Y, Sun X, Li Q, Huang J, Liu L, Zhang X, Zhang W, Liu X	10.1038/S41467-023-43922-8	2024-01-31	56198
Gs	αs	Human	-	51	β1	Human	γ2	Human	Cryo-EM	8IQ4	8IQ4_refined	2.7	PF2R	FP	Prostanoid	A (Rhodopsin)	Human	-	Nanobody-35	-	Carboprost pubchem chembl_ligand drugbank chembl_ligand pubchem pubchem pubchem	small-molecule	Agonist	PGF_2α, PGI₂, PGE₂, thromboxane A₂, PGD₂	small-molecule	Lv X, Gao K, Nie J, Zhang X, Zhang S, Ren Y, Sun X, Li Q, Huang J, Liu L, Zhang X, Zhang W, Liu X	10.1038/S41467-023-43922-8	2024-01-31	56198
G12/13	α13	Human	-	56	β1	Human	γ2	Human	Cryo-EM	8IKL	-	2.3	AGRE5	ADGRE5	ADGRE	B2 (Adhesion)	Human	-	-	-	Apo (no ligand)	none	Apo (no ligand)	-	-	Mao C, Zhao RJ, Dong YJ, Gao M, Chen LN, Zhang C, Xiao P, Guo J, Qin J, Shen DD, Ji SY, Zang SK, Zhang H, Wang WW, Shen Q, Sun JP, Zhang Y	10.1016/J.MOLCEL.2023.12.020	2024-01-24	56213
Gi/o	αi1	Human	-	61	β1	Human	γ2	Human	Cryo-EM	8J24	8J24_refined	2.6	FFAR2	FFA2	Free fatty acid	A (Rhodopsin)	Human	-	scFv16	-	Acetic acid pubchem	small-molecule	Agonist	butyric acid, acetic acid, trans-2-methylcrotonic acid, propanoic acid	small-molecule	Li F, Tai L, Sun X, Lv Z, Tang W, Wang T, Zhao Z, Gong D, Ma S, Tang S, Gu Q, Zhu X, Yu M, Liu X, Wang J	10.1038/S41422-023-00914-Z	2024-01-24	56200
Gi/o	αi1	Human	-	61	β1	Human	γ2	Human	Cryo-EM	8J22	8J22_refined	3.2	FFAR2	FFA2	Free fatty acid	A (Rhodopsin)	Human	-	scFv16	-	CHEMBL4176503 chembl_ligand pubchem	small-molecule	Agonist	butyric acid, acetic acid, trans-2-methylcrotonic acid, propanoic acid	small-molecule	Li F, Tai L, Sun X, Lv Z, Tang W, Wang T, Zhao Z, Gong D, Ma S, Tang S, Gu Q, Zhu X, Yu M, Liu X, Wang J	10.1038/S41422-023-00914-Z	2024-01-24	56200
Gi/o	αi1	Human	-	63	β1	Human	γ2	Human	Cryo-EM	8J20	-	3.2	FFAR3	FFA3	Free fatty acid	A (Rhodopsin)	Human	-	scFv16	-	pentanoic acid pubchem gtoplig chembl_ligand drugbank (4R)-N-[2,5-bis(chloranyl)phenyl]-4-(furan-2-yl)-2-methyl-5-oxidanylidene-4,6,7,8-tetrahydro-1H-quinoline-3-carboxamide pubchem	small-molecule small-molecule	Agonist PAM	butyric acid, propanoic acid	small-molecule	Li F, Tai L, Sun X, Lv Z, Tang W, Wang T, Zhao Z, Gong D, Ma S, Tang S, Gu Q, Zhu X, Yu M, Liu X, Wang J	10.1038/S41422-023-00914-Z	2024-01-24	56200
Gi/o	αi1	Human	-	63	β1	Human	γ2	Human	Cryo-EM	8J21	8J21_refined	3.3	FFAR3	FFA3	Free fatty acid	A (Rhodopsin)	Human	-	scFv16	-	butyric acid pubchem gtoplig chembl_ligand drugbank	small-molecule	Agonist	butyric acid, propanoic acid	small-molecule	Li F, Tai L, Sun X, Lv Z, Tang W, Wang T, Zhao Z, Gong D, Ma S, Tang S, Gu Q, Zhu X, Yu M, Liu X, Wang J	10.1038/S41422-023-00914-Z	2024-01-24	56200
Gq/11	αq	Human	-	59	β1	Human	γ2	Human	Cryo-EM	8T3S	-	3.1	FFAR2	FFA2	Free fatty acid	A (Rhodopsin)	Human	-	scFv16	-	butyric acid pubchem gtoplig chembl_ligand drugbank	small-molecule	Agonist	butyric acid, acetic acid, trans-2-methylcrotonic acid, propanoic acid	small-molecule	Zhang X, Guseinov AA, Jenkins L, Li K, Tikhonova IG, Milligan G, Zhang C	10.1126/SCIADV.ADJ2384	2024-01-24	56208
Gq/11	αq	Human	-	59	β1	Human	γ2	Human	Cryo-EM	8T3V	-	3.4	FFAR1	FFA1	Free fatty acid	A (Rhodopsin)	Human	-	scFv16	-	docosahexaenoic acid pubchem gtoplig chembl_ligand drug_central drugbank pubchem	small-molecule	Agonist	myristic acid, oleic acid, docosahexaenoic acid, α-linolenic acid	small-molecule	Zhang X, Guseinov AA, Jenkins L, Li K, Tikhonova IG, Milligan G, Zhang C	10.1126/SCIADV.ADJ2384	2024-01-24	56208
Gq/11	αq	Human	-	59	β1	Human	γ2	Human	Cryo-EM	8T3Q	8T3Q_refined	3.1	FFAR4	FFA4	Free fatty acid	A (Rhodopsin)	Human	-	scFv16	-	docosahexaenoic acid pubchem gtoplig chembl_ligand drug_central drugbank pubchem	small-molecule	Agonist	oleic acid, myristic acid, linoleic acid, α-linolenic acid	small-molecule	Zhang X, Guseinov AA, Jenkins L, Li K, Tikhonova IG, Milligan G, Zhang C	10.1126/SCIADV.ADJ2384	2024-01-24	56208
Gq/11	αq	Human	-	59	β1	Human	γ2	Human	Cryo-EM	8T3O	-	3.1	FFAR4	FFA4	Free fatty acid	A (Rhodopsin)	Human	-	scFv16	-	TUG-891 pubchem gtoplig chembl_ligand	small-molecule	Agonist	oleic acid, myristic acid, linoleic acid, α-linolenic acid	small-molecule	Zhang X, Guseinov AA, Jenkins L, Li K, Tikhonova IG, Milligan G, Zhang C	10.1126/SCIADV.ADJ2384	2024-01-17	56208
Gq/11	αq	Human	Gq-Gs chimera	60	β1	Human	γ2	Human	Cryo-EM	8J9N	-	3.5	FZD1	FZD₁	Frizzled	F (Frizzled)	Human	-	scFv16	-	Apo (no ligand)	none	Apo (no ligand)	Wnt-1, Wnt-3a, Wnt-7b, Wnt-5a, Wnt-2	peptide	Zhang Z, Lin X, Wei L, Wu Y, Xu L, Wu L, Wei X, Zhao S, Zhu X, Xu F	10.1038/S41421-023-00627-Y	2024-01-17	56208
Gs	αs	Human	-	60	β1	Human	γ2	Human	Cryo-EM	8JHI	-	3.2	FZD3	FZD₃	Frizzled	F (Frizzled)	Human	-	Nanobody-35	-	Apo (no ligand)	none	Apo (no ligand)	-	-	-	-	2024-01-17	56198
Gs	αs	Human	-	61	β1	Human	γ2	Human	Cryo-EM	8JHB	-	3.3	FZD6	FZD₆	Frizzled	F (Frizzled)	Human	-	Nanobody-35	-	Apo (no ligand)	none	Apo (no ligand)	Wnt-5a, Wnt-3a, Wnt-4	peptide	Zhang Z, Lin X, Wei L, Wu Y, Xu L, Wu L, Wei X, Zhao S, Zhu X, Xu F	10.1038/S41421-023-00627-Y	2024-01-17	56198
Gs	αs2	Bovine	-	100	-	-	-	-	Cryo-EM	8BV5	-	3.5	-	-	-	-	-	-	-	Adenylate cyclase type 8	-	-	-	-	-	Khanppnavar B, Schuster D, Lavriha P, Uliana F, Ozel M, Mehta V, Leitner A, Picotti P, Korkhov VM	38351373	2024-01-17	56215
Gi/o	αi1	Human	-	61	β1	Human	γ2	Human	Cryo-EM	8JGG	8JGG_refined	3.0	MRGX1	MRGPRX1	A orphans	A (Rhodopsin)	Human	-	scFv16	-	bovine adrenal medulla peptide 8-22 pubchem gtoplig chembl_ligand pubchem	peptide	Agonist	bovine adrenal medulla peptide 8-22	peptide	Guo L, Zhang Y, Fang G, Tie L, Zhuang Y, Xue C, Liu Q, Zhang M, Zhu K, You C, Xu P, Yuan Q, Zhang C, Liu L, Rong N, Peng S, Liu Y, Wang C, Luo X, Lv Z, Kang D, Yu X, Zhang C, Jiang Y, Dong X, Zhou J, Liu Z, Yang F, Eric Xu H, Sun JP	10.1038/S41467-023-40705-Z	2024-01-10	56200
Gi/o	αi1	Human	-	61	β1	Human	γ2	Human	Cryo-EM	8J6J	8J6J_refined	2.8	HCAR2	HCA₂	Hydroxycarboxylic acid	A (Rhodopsin)	Human	-	scFv16	-	GSK256073 pubchem gtoplig chembl_ligand	small-molecule	Agonist	butyric acid, β-D-hydroxybutyric acid	small-molecule	Zhu S, Yuan Q, Li X, He X, Shen S, Wang D, Li J, Cheng X, Duan X, Xu HE, Duan J	10.1016/J.CELREP.2023.113406	2024-01-10	56200
Gi/o	αi1	Human	-	58	β1	Human	γ2	Human	Cryo-EM	8GDC	8GDC_refined	3.5	PE2R3	EP₃	Prostanoid	A (Rhodopsin)	Human	-	-	-	PGE₂ pubchem gtoplig chembl_ligand drugbank drug_central gtoplig pubchem	small-molecule	Agonist	PGE₁, PGF_2α, PGI₂, PGE₂, thromboxane A₂, PGD₂	small-molecule	Huang SM, Xiong MY, Liu L, Mu J, Wang MW, Jia YL, Cai K, Tie L, Zhang C, Cao S, Wen X, Wang JL, Guo SC, Li Y, Qu CX, He QT, Cai BY, Xue C, Gan S, Xie Y, Cong X, Yang Z, Kong W, Li S, Li Z, Xiao P, Yang F, Yu X, Guan YF, Zhang X, Liu Z, Yang BX, Du Y, Sun JP	10.1073/PNAS.2216329120	2024-01-10	56200
Gi/o	αi1	Human	-	61	β1	Human	γ2	Human	Cryo-EM	8JGB	8JGB_refined	2.8	MRGX1	MRGPRX1	A orphans	A (Rhodopsin)	Human	-	scFv16	-	Conorfamide-Tx2	protein	Agonist	bovine adrenal medulla peptide 8-22	peptide	Guo L, Zhang Y, Fang G, Tie L, Zhuang Y, Xue C, Liu Q, Zhang M, Zhu K, You C, Xu P, Yuan Q, Zhang C, Liu L, Rong N, Peng S, Liu Y, Wang C, Luo X, Lv Z, Kang D, Yu X, Zhang C, Jiang Y, Dong X, Zhou J, Liu Z, Yang F, Eric Xu H, Sun JP	10.1038/S41467-023-40705-Z	2024-01-10	56200
Gq/11	αq	Human	-	60	β1	Human	γ2	Human	Cryo-EM	8JGF	8JGF_refined	2.7	MRGX1	MRGPRX1	A orphans	A (Rhodopsin)	Human	-	scFv16	-	bovine adrenal medulla peptide 8-22 pubchem gtoplig chembl_ligand pubchem	peptide	Agonist	bovine adrenal medulla peptide 8-22	peptide	Guo L, Zhang Y, Fang G, Tie L, Zhuang Y, Xue C, Liu Q, Zhang M, Zhu K, You C, Xu P, Yuan Q, Zhang C, Liu L, Rong N, Peng S, Liu Y, Wang C, Luo X, Lv Z, Kang D, Yu X, Zhang C, Jiang Y, Dong X, Zhou J, Liu Z, Yang F, Eric Xu H, Sun JP	10.1038/S41467-023-40705-Z	2024-01-10	56208
Gs	αs	Human	-	58	β1	Human	γ2	Human	Cryo-EM	8GDA	8GDA_refined	3.3	PE2R4	EP₄	Prostanoid	A (Rhodopsin)	Human	-	-	-	(2S,5R)-5-[(1E,3S)-4,4-difluoro-3-hydroxy-4-phenylbut-1-en-1-yl]-1-[6-(1H-tetrazol-5-yl)hexyl]pyrrolidin-2-ol pubchem	small-molecule	Agonist	PGE₁, PGF_2α, PGI₂, PGE₂, thromboxane A₂, PGD₂	small-molecule	Huang SM, Xiong MY, Liu L, Mu J, Wang MW, Jia YL, Cai K, Tie L, Zhang C, Cao S, Wen X, Wang JL, Guo SC, Li Y, Qu CX, He QT, Cai BY, Xue C, Gan S, Xie Y, Cong X, Yang Z, Kong W, Li S, Li Z, Xiao P, Yang F, Yu X, Guan YF, Zhang X, Liu Z, Yang BX, Du Y, Sun JP	10.1073/PNAS.2216329120	2024-01-10	56198
Gs	αs	Human	-	54	β1	Human	γ2	Human	Cryo-EM	8GD9	-	3.2	PE2R4	EP₄	Prostanoid	A (Rhodopsin)	Human	-	-	-	4-({2-[(1R,2R,3R,5S)-3,5-dihydroxy-2-{(3S)-3-hydroxy-4-[3-(methoxymethyl)phenyl]butyl}cyclopentyl]ethyl}sulfanyl)butanoic acid pubchem	small-molecule	Agonist	PGE₁, PGF_2α, PGI₂, PGE₂, thromboxane A₂, PGD₂	small-molecule	Huang SM, Xiong MY, Liu L, Mu J, Wang MW, Jia YL, Cai K, Tie L, Zhang C, Cao S, Wen X, Wang JL, Guo SC, Li Y, Qu CX, He QT, Cai BY, Xue C, Gan S, Xie Y, Cong X, Yang Z, Kong W, Li S, Li Z, Xiao P, Yang F, Yu X, Guan YF, Zhang X, Liu Z, Yang BX, Du Y, Sun JP	10.1073/PNAS.2216329120	2024-01-10	56198
Gs	αs	Human	-	59	β1	Human	γ2	Human	Cryo-EM	8GDB	8GDB_refined	3.1	PE2R4	EP₄	Prostanoid	A (Rhodopsin)	Human	-	-	-	PGE₂ pubchem gtoplig chembl_ligand drugbank drug_central gtoplig pubchem	small-molecule	Agonist	PGE₁, PGF_2α, PGI₂, PGE₂, thromboxane A₂, PGD₂	small-molecule	Huang SM, Xiong MY, Liu L, Mu J, Wang MW, Jia YL, Cai K, Tie L, Zhang C, Cao S, Wen X, Wang JL, Guo SC, Li Y, Qu CX, He QT, Cai BY, Xue C, Gan S, Xie Y, Cong X, Yang Z, Kong W, Li S, Li Z, Xiao P, Yang F, Yu X, Guan YF, Zhang X, Liu Z, Yang BX, Du Y, Sun JP	10.1073/PNAS.2216329120	2024-01-10	56198
Gs	αs	Human	-	60	β1	Human	γ2	Human	Cryo-EM	8UHB	8UHB_refined	3.4	TAAR1	TA₁	Trace amine	A (Rhodopsin)	Human	BRIL	Nanobody-35	-	CHEMBL3684869 chembl_ligand pubchem	small-molecule	Agonist	tyramine, (+)-Octopamine, octopamine, β-phenylethylamine, CHEMBL1160703, 3-iodothyronamine, dopamine	small-molecule	Zilberg G, Parpounas AK, Warren AL, Yang S, Wacker D	10.1038/S41467-023-44601-4	2024-01-10	56198
Gi/o	αi1	Human	-	56	β1	Human	γ2	Human	Cryo-EM	8GCM	-	3.5	PE2R4	EP₄	Prostanoid	A (Rhodopsin)	Human	-	scFv16	-	(5S)-5-[(3R)-4,4-difluoro-3-hydroxy-4-phenylbutyl]-1-[6-(1H-tetrazol-5-yl)hexyl]pyrrolidin-2-one pubchem	lipid	Agonist	PGE₁, PGF_2α, PGI₂, PGE₂, thromboxane A₂, PGD₂	small-molecule	Huang SM, Xiong MY, Liu L, Mu J, Wang MW, Jia YL, Cai K, Tie L, Zhang C, Cao S, Wen X, Wang JL, Guo SC, Li Y, Qu CX, He QT, Cai BY, Xue C, Gan S, Xie Y, Cong X, Yang Z, Kong W, Li S, Li Z, Xiao P, Yang F, Yu X, Guan YF, Zhang X, Liu Z, Yang BX, Du Y, Sun JP	10.1073/PNAS.2216329120	2024-01-03	56200
Gi/o	αi1	Human	-	61	β1	Human	γ2	Human	Cryo-EM	8IJD	-	3.3	HCAR2	HCA₂	Hydroxycarboxylic acid	A (Rhodopsin)	Human	-	scFv16	-	MK 6892 pubchem gtoplig chembl_ligand pubchem	small-molecule	Agonist	butyric acid, β-D-hydroxybutyric acid	small-molecule	Pan X, Ye F, Ning P, Zhang Z, Li X, Zhang B, Wang Q, Chen G, Gao W, Qiu C, Wu Z, Li J, Zhu L, Xia J, Gong K, Du Y	10.1038/S41421-023-00610-7	2024-01-03	56200
Gi/o	αi1	Human	-	61	β1	Human	γ2	Human	Cryo-EM	8IJB	8IJB_refined	3.2	HCAR2	HCA₂	Hydroxycarboxylic acid	A (Rhodopsin)	Human	-	scFv16	-	5-Methyl-4-oxidanyl-pyrazin-4-ium-2-carboxylic acid pubchem	small-molecule	Agonist	butyric acid, β-D-hydroxybutyric acid	small-molecule	Pan X, Ye F, Ning P, Zhang Z, Li X, Zhang B, Wang Q, Chen G, Gao W, Qiu C, Wu Z, Li J, Zhu L, Xia J, Gong K, Du Y	10.1038/S41421-023-00610-7	2024-01-03	56200
Gi/o	αi1	Human	-	61	β1	Human	γ2	Human	Cryo-EM	8IJA	-	2.7	HCAR2	HCA₂	Hydroxycarboxylic acid	A (Rhodopsin)	Human	-	scFv16	-	nicotinic acid pubchem gtoplig chembl_ligand drugbank drug_central gtoplig pubchem	small-molecule	Agonist	butyric acid, β-D-hydroxybutyric acid	small-molecule	Pan X, Ye F, Ning P, Zhang Z, Li X, Zhang B, Wang Q, Chen G, Gao W, Qiu C, Wu Z, Li J, Zhu L, Xia J, Gong K, Du Y	10.1038/S41421-023-00610-7	2024-01-03	56200
Gi/o	αi1	Human	-	61	β1	Human	γ2	Human	Cryo-EM	8GCP	8GCP_refined	3.1	PE2R4	EP₄	Prostanoid	A (Rhodopsin)	Human	-	scFv16	-	PGE₂ pubchem gtoplig chembl_ligand drugbank drug_central gtoplig pubchem	small-molecule	Agonist	PGE₁, PGF_2α, PGI₂, PGE₂, thromboxane A₂, PGD₂	small-molecule	Huang SM, Xiong MY, Liu L, Mu J, Wang MW, Jia YL, Cai K, Tie L, Zhang C, Cao S, Wen X, Wang JL, Guo SC, Li Y, Qu CX, He QT, Cai BY, Xue C, Gan S, Xie Y, Cong X, Yang Z, Kong W, Li S, Li Z, Xiao P, Yang F, Yu X, Guan YF, Zhang X, Liu Z, Yang BX, Du Y, Sun JP	10.1073/PNAS.2216329120	2024-01-03	56200
Gi/o	αi1	Human	-	61	β1	Human	γ2	Human	Cryo-EM	8IJ3	8IJ3_refined	3.3	HCAR2	HCA₂	Hydroxycarboxylic acid	A (Rhodopsin)	Human	-	scFv16	-	Apo (no ligand)	none	Apo (no ligand)	butyric acid, β-D-hydroxybutyric acid	small-molecule	Pan X, Ye F, Ning P, Zhang Z, Li X, Zhang B, Wang Q, Chen G, Gao W, Qiu C, Wu Z, Li J, Zhu L, Xia J, Gong K, Du Y	10.1038/S41421-023-00610-7	2024-01-03	56200
Gs	αs	Human	-	59	β1	Human	γ2	Human	Cryo-EM	8W8Q	8W8Q_refined	2.9	GP101	GPR101	A orphans	A (Rhodopsin)	Human	BRIL	Nanobody-35	-	Apo (no ligand)	none	Apo (no ligand)	-	-	Yang Z, Wang JY, Yang F, Zhu KK, Wang GP, Guan Y, Ning SL, Lu Y, Li Y, Zhang C, Zheng Y, Zhou SH, Wang XW, Wang MW, Xiao P, Yi F, Zhang C, Zhang PJ, Xu F, Liu BH, Zhang H, Yu X, Gao N, Sun JP	10.1038/S41589-023-01456-6	2024-01-03	56198
Gs	αs	Human	-	60	β1	Human	γ2	Human	Cryo-EM	8W8R	-	3.3	GP101	GPR101	A orphans	A (Rhodopsin)	Human	-	scFv16	-	1-(4-Methylpyridin-2-yl)-3-[3-(trifluoromethyl)phenyl]thiourea pubchem	small-molecule	Agonist	-	-	Yang Z, Wang JY, Yang F, Zhu KK, Wang GP, Guan Y, Ning SL, Lu Y, Li Y, Zhang C, Zheng Y, Zhou SH, Wang XW, Wang MW, Xiao P, Yi F, Zhang C, Zhang PJ, Xu F, Liu BH, Zhang H, Yu X, Gao N, Sun JP	10.1038/S41589-023-01456-6	2024-01-03	56198
Gi/o	αi1	Human	-	62	β1	Rat	γ2	Bovine	Cryo-EM	8XBH	8XBH_refined	2.8	GPR34	GPR34	A orphans	A (Rhodopsin)	Human	-	scFv16	-	CHEMBL4758243 chembl_ligand pubchem	small-molecule	Agonist	lysophosphatidylserine	small-molecule	-	-	2023-12-27	56200
Gq/11	αq	Human	-	57	β1	Human	γ2	Human	Cryo-EM	8WCB	-	3.1	TAAR1	TA₁	Trace amine	A (Rhodopsin)	Mouse	-	scFv16	-	Cyclohexylammonium ion pubchem	small-molecule	Agonist	tyramine, β-phenylethylamine, 3-iodothyronamine	small-molecule	Shang P, Rong N, Jiang JJ, Cheng J, Zhang MH, Kang D, Qi L, Guo L, Yang GM, Liu Q, Zhou Z, Li XB, Zhu KK, Meng QB, Han X, Yan W, Kong Y, Yang L, Wang X, Lei D, Feng X, Liu X, Yu X, Wang Y, Li Q, Shao ZH, Yang F, Sun JP	10.1016/J.CELL.2023.10.014	2023-12-27	56208
Gq/11	αq	Human	-	58	β1	Human	γ2	Human	Cryo-EM	8WC9	-	3.2	TAAR1	TA₁	Trace amine	A (Rhodopsin)	Mouse	-	scFv16	-	CHEMBL476516 chembl_ligand pubchem	small-molecule	Agonist	tyramine, β-phenylethylamine, 3-iodothyronamine	small-molecule	Shang P, Rong N, Jiang JJ, Cheng J, Zhang MH, Kang D, Qi L, Guo L, Yang GM, Liu Q, Zhou Z, Li XB, Zhu KK, Meng QB, Han X, Yan W, Kong Y, Yang L, Wang X, Lei D, Feng X, Liu X, Yu X, Wang Y, Li Q, Shao ZH, Yang F, Sun JP	10.1016/J.CELL.2023.10.014	2023-12-27	56208
Gs	αs	Human	-	61	β1	Human	γ2	Human	Cryo-EM	8HJ1	8HJ1_refined	3.3	GPR21	GPR21	A orphans	A (Rhodopsin)	Human	-	Nanobody-35	-	Apo (no ligand)	none	Apo (no ligand)	-	-	Lin X, Chen B, Wu Y, Han Y, Qi A, Wang J, Yang Z, Wei X, Zhao T, Wu L, Xie X, Sun J, Zheng J, Zhao S, Xu F	10.1038/S41467-023-35882-W	2023-12-27	56198
Gs	αs	Human	-	59	β1	Human	γ2	Human	Cryo-EM	8WCA	-	3.5	TAAR1	TA₁	Trace amine	A (Rhodopsin)	Human	-	scFv16	-	2-Phenylethanaminium pubchem	small-molecule	Agonist	tyramine, (+)-Octopamine, octopamine, β-phenylethylamine, CHEMBL1160703, 3-iodothyronamine, dopamine	small-molecule	Shang P, Rong N, Jiang JJ, Cheng J, Zhang MH, Kang D, Qi L, Guo L, Yang GM, Liu Q, Zhou Z, Li XB, Zhu KK, Meng QB, Han X, Yan W, Kong Y, Yang L, Wang X, Lei D, Feng X, Liu X, Yu X, Wang Y, Li Q, Shao ZH, Yang F, Sun JP	10.1016/J.CELL.2023.10.014	2023-12-27	56198
Gs	αs	Human	-	59	β1	Human	γ2	Human	Cryo-EM	8WC4	-	3.1	TAAR1	TA₁	Trace amine	A (Rhodopsin)	Mouse	-	scFv16	-	CHEMBL476516 chembl_ligand pubchem	small-molecule	Agonist	tyramine, β-phenylethylamine, 3-iodothyronamine	small-molecule	Shang P, Rong N, Jiang JJ, Cheng J, Zhang MH, Kang D, Qi L, Guo L, Yang GM, Liu Q, Zhou Z, Li XB, Zhu KK, Meng QB, Han X, Yan W, Kong Y, Yang L, Wang X, Lei D, Feng X, Liu X, Yu X, Wang Y, Li Q, Shao ZH, Yang F, Sun JP	10.1016/J.CELL.2023.10.014	2023-12-27	56198
Gs	αs	Human	-	59	β1	Human	γ2	Human	Cryo-EM	8WC3	-	3.0	TAAR1	TA₁	Trace amine	A (Rhodopsin)	Mouse	-	scFv16	-	ulotaront pubchem gtoplig drugbank chembl_ligand pubchem	small-molecule	Agonist	tyramine, β-phenylethylamine, 3-iodothyronamine	small-molecule	Shang P, Rong N, Jiang JJ, Cheng J, Zhang MH, Kang D, Qi L, Guo L, Yang GM, Liu Q, Zhou Z, Li XB, Zhu KK, Meng QB, Han X, Yan W, Kong Y, Yang L, Wang X, Lei D, Feng X, Liu X, Yu X, Wang Y, Li Q, Shao ZH, Yang F, Sun JP	10.1016/J.CELL.2023.10.014	2023-12-27	56198
Gs	αs	Human	-	58	β1	Human	γ2	Human	Cryo-EM	8WC7	-	3.1	TAAR1	TA₁	Trace amine	A (Rhodopsin)	Mouse	-	scFv16	-	2-[4-(3-Fluorophenyl)phenyl]ethan-1-amine pubchem	small-molecule	Agonist	tyramine, β-phenylethylamine, 3-iodothyronamine	small-molecule	Shang P, Rong N, Jiang JJ, Cheng J, Zhang MH, Kang D, Qi L, Guo L, Yang GM, Liu Q, Zhou Z, Li XB, Zhu KK, Meng QB, Han X, Yan W, Kong Y, Yang L, Wang X, Lei D, Feng X, Liu X, Yu X, Wang Y, Li Q, Shao ZH, Yang F, Sun JP	10.1016/J.CELL.2023.10.014	2023-12-27	56198
Gs	αs	Human	-	56	β1	Human	γ2	Human	Cryo-EM	8WC8	-	2.9	TAAR1	TA₁	Trace amine	A (Rhodopsin)	Human	-	scFv16	-	CHEMBL476516 chembl_ligand pubchem	small-molecule	Agonist	tyramine, (+)-Octopamine, octopamine, β-phenylethylamine, CHEMBL1160703, 3-iodothyronamine, dopamine	small-molecule	Shang P, Rong N, Jiang JJ, Cheng J, Zhang MH, Kang D, Qi L, Guo L, Yang GM, Liu Q, Zhou Z, Li XB, Zhu KK, Meng QB, Han X, Yan W, Kong Y, Yang L, Wang X, Lei D, Feng X, Liu X, Yu X, Wang Y, Li Q, Shao ZH, Yang F, Sun JP	10.1016/J.CELL.2023.10.014	2023-12-27	56198
Gs	αs	Human	-	58	β1	Human	γ2	Human	Cryo-EM	8WC5	-	3.3	TAAR1	TA₁	Trace amine	A (Rhodopsin)	Mouse	-	scFv16	-	Tetramethylammonium chembl_ligand pubchem	small-molecule	Agonist	tyramine, β-phenylethylamine, 3-iodothyronamine	small-molecule	Shang P, Rong N, Jiang JJ, Cheng J, Zhang MH, Kang D, Qi L, Guo L, Yang GM, Liu Q, Zhou Z, Li XB, Zhu KK, Meng QB, Han X, Yan W, Kong Y, Yang L, Wang X, Lei D, Feng X, Liu X, Yu X, Wang Y, Li Q, Shao ZH, Yang F, Sun JP	10.1016/J.CELL.2023.10.014	2023-12-27	56198
Gs	αs	Human	-	58	β1	Human	γ2	Human	Cryo-EM	8WC6	-	3.2	TAAR1	TA₁	Trace amine	A (Rhodopsin)	Mouse	-	scFv16 Nanobody-35	-	2-Phenylethanaminium pubchem	small-molecule	Agonist	tyramine, β-phenylethylamine, 3-iodothyronamine	small-molecule	Shang P, Rong N, Jiang JJ, Cheng J, Zhang MH, Kang D, Qi L, Guo L, Yang GM, Liu Q, Zhou Z, Li XB, Zhu KK, Meng QB, Han X, Yan W, Kong Y, Yang L, Wang X, Lei D, Feng X, Liu X, Yu X, Wang Y, Li Q, Shao ZH, Yang F, Sun JP	10.1016/J.CELL.2023.10.014	2023-12-27	56198
Gi/o	αi1	Human	-	60	β1	Human	γ2	Human	Cryo-EM	8U1U	-	3.1	CCR8	CCR8	Chemokine	A (Rhodopsin)	Human	-	scFv16	-	CCL1	protein	Agonist	CCL8, CCL1	peptide	-	-	2023-12-20	56200
Gi/o	αi1	Human	-	64	β1	Human	γ2	Human	Cryo-EM	8HOC	-	3.0	HRH4	H₄	Histamine	A (Rhodopsin)	Human	-	scFv16	-	imetit pubchem gtoplig chembl_ligand pubchem	small-molecule	Agonist	histamine, CCL16	small-molecule	-	-	2023-12-20	56200
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	8HN8	-	3.0	HRH4	H₄	Histamine	A (Rhodopsin)	Human	-	scFv16	-	histamine pubchem gtoplig chembl_ligand drug_central drugbank gtoplig pubchem	small-molecule	Agonist	histamine, CCL16	small-molecule	-	-	2023-12-20	56200
Gs	αs	Human	-	40	β1	Human	γ2	Human	Cryo-EM	8HTI	-	3.0	O52E4	OR52E4	Odorant family 52	O1 (fish-like odorant)	Human	-	Nanobody-35	-	OCTANOIC ACID chembl_ligand pubchem pubchem	small-molecule	Agonist	-	-	Choi C, Bae J, Kim S, Lee S, Kang H, Kim J, Bang I, Kim K, Huh WK, Seok C, Park H, Im W, Choi HJ	10.1038/S41467-023-43983-9	2023-12-20	56198
Gs	αl	Mouse	-	100	-	-	-	-	X-ray	8HTG	-	2.9	-	-	-	-	-	-	-	-	-	-	-	-	-	Choi C, Bae J, Kim S, Lee S, Kang H, Kim J, Bang I, Kim K, Huh WK, Seok C, Park H, Im W, Choi HJ	38062020	2023-12-20	56233
Gs	αs2	Bovine	-	100	-	-	-	-	Cryo-EM	8BUZ	-	3.5	-	-	-	-	-	-	-	Adenylate cyclase type 8	-	-	-	-	-	Khanppnavar B, Schuster D, Lavriha P, Uliana F, Ozel M, Mehta V, Leitner A, Picotti P, Korkhov VM	38351373	2023-12-13	56215
Gi/o	αi1	Human	-	64	β1	Human	γ2	Human	Cryo-EM	8J6R	-	2.8	HCAR2	HCA₂	Hydroxycarboxylic acid	A (Rhodopsin)	Human	-	scFv16	-	MK 6892 pubchem gtoplig chembl_ligand pubchem	small-molecule	Agonist	butyric acid, β-D-hydroxybutyric acid	small-molecule	Mao C, Gao M, Zang SK, Zhu Y, Shen DD, Chen LN, Yang L, Wang Z, Zhang H, Wang WW, Shen Q, Lu Y, Ma X, Zhang Y	10.1038/S41467-023-43537-Z	2023-12-06	56200
Gi/o	αi1	Human	-	64	β1	Human	γ2	Human	Cryo-EM	8J6Q	-	2.6	HCAR2	HCA₂	Hydroxycarboxylic acid	A (Rhodopsin)	Human	-	scFv16	-	β-D-hydroxybutyric acid pubchem gtoplig chembl_ligand	small-molecule	Agonist	butyric acid, β-D-hydroxybutyric acid	small-molecule	Mao C, Gao M, Zang SK, Zhu Y, Shen DD, Chen LN, Yang L, Wang Z, Zhang H, Wang WW, Shen Q, Lu Y, Ma X, Zhang Y	10.1038/S41467-023-43537-Z	2023-12-06	56200
Gi/o	αi1	Human	-	64	β1	Human	γ2	Human	Cryo-EM	8J6P	-	2.6	HCAR2	HCA₂	Hydroxycarboxylic acid	A (Rhodopsin)	Human	-	scFv16	-	nicotinic acid pubchem gtoplig chembl_ligand drugbank drug_central gtoplig pubchem	small-molecule	Agonist	butyric acid, β-D-hydroxybutyric acid	small-molecule	Mao C, Gao M, Zang SK, Zhu Y, Shen DD, Chen LN, Yang L, Wang Z, Zhang H, Wang WW, Shen Q, Lu Y, Ma X, Zhang Y	10.1038/S41467-023-43537-Z	2023-12-06	56200
Gi/o	αi1	Human	-	55	β1	Human	γ2	Human	Cryo-EM	8FEG	-	2.5	OPRK	κ	Opioid	A (Rhodopsin)	Human	-	scFv16	-	ACE-TYR-ALA-DTY-THR-THR-CYS-THR-DPN-XT9	peptide	Agonist	dynorphin B, dynorphin A-(1-13), dynorphin A-(1-8), β-endorphin, β-neoendorphin, α-neoendorphin, [Met]enkephalin, dynorphin A, [Leu]enkephalin, big dynorphin	peptide	Muratspahic E, Deibler K, Han J, Tomasevic N, Jadhav KB, Olive-Marti AL, Hochrainer N, Hellinger R, Koehbach J, Fay JF, Rahman MH, Hegazy L, Craven TW, Varga BR, Bhardwaj G, Appourchaux K, Majumdar S, Muttenthaler M, Hosseinzadeh P, Craik DJ, Spetea M, Che T, Baker D, Gruber CW	10.1038/s41467-023-43718-w	2023-12-06	56200
Gq/11	αq	Human	-	61	β1	Human	γ2	Human	Cryo-EM	8IA7	8IA7_refined	3.1	GASR	CCK₂	Cholecystokinin	A (Rhodopsin)	Human	-	-	-	CHEMBL216166 chembl_ligand pubchem	protein	Agonist	CCK-39, desulfated gastrin-14, gastrin-71, desulfated gastrin-71, desulfated gastrin-17, gastrin-17, desulfated gastrin-34, desulfated cholecystokinin-8, gastrin-14, CCK-4, CCK-58, gastrin-34, CCK-8, CCK-33	peptide	Ding Y, Zhang H, Liao YY, Chen LN, Ji SY, Qin J, Mao C, Shen DD, Lin L, Wang H, Zhang Y, Li XM	10.1038/S41421-022-00420-3	2023-12-06	56208
Gq/11	αq	Human	-	99	-	-	-	-	Cryo-EM	8UQN	-	3.4	-	-	-	-	-	-	-	1-phosphatidylinositol 4 5-bisphosphate phosphodiesterase beta-3	-	-	-	-	-	Falzone ME, MacKinnon R	37991948	2023-12-06	56208
Gq/11	αq	Human	-	99	β1	Human	γ2	Human	Cryo-EM	8UQO	-	3.4	-	-	-	-	-	-	-	1-phosphatidylinositol 4 5-bisphosphate phosphodiesterase beta-3	-	-	-	-	-	Falzone ME, MacKinnon R	37991948	2023-12-06	56208
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	8HNM	-	2.9	CXCR3	CXCR3	Chemokine	A (Rhodopsin)	Human	-	scFv16	-	CHEMBL2220409 chembl_ligand chembl_ligand pubchem	small-molecule	Agonist	CXCL11, CCL13, CCL11, CXCL10, CCL20, CXCL12α, CXCL9, CCL7, CCL19, CCL5	peptide	Jiao H, Pang B, Liu A, Chen Q, Pan Q, Wang X, Xu Y, Chiang YC, Ren R, Hu H	10.1038/S41594-023-01175-5	2023-11-29	56200
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	8K2X	8K2X_refined	3.2	CXCR3	CXCR3	Chemokine	A (Rhodopsin)	Human	BRIL	scFv16	-	C-X-C motif chemokine 10	small-molecule	Agonist	CXCL11, CCL13, CCL11, CXCL10, CCL20, CXCL12α, CXCL9, CCL7, CCL19, CCL5	peptide	Jiao H, Pang B, Chiang YC, Chen Q, Pan Q, Ren R, Hu H	10.1038/S41421-023-00617-0	2023-11-29	56200
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	8HNK	-	3.0	CXCR3	CXCR3	Chemokine	A (Rhodopsin)	Human	-	scFv16	-	CXCL11 gtoplig	peptide	Agonist	CXCL11, CCL13, CCL11, CXCL10, CCL20, CXCL12α, CXCL9, CCL7, CCL19, CCL5	peptide	Jiao H, Pang B, Liu A, Chen Q, Pan Q, Wang X, Xu Y, Chiang YC, Ren R, Hu H	10.1038/S41594-023-01175-5	2023-11-29	56200
Gi/o	αi1	Human	-	100	β1	Human	γ2	Human	Cryo-EM	8HNL	-	3.0	-	-	-	-	-	-	single-chain variable fragment scFv16	-	-	-	-	-	-	Jiao H, Pang B, Liu A, Chen Q, Pan Q, Wang X, Xu Y, Chiang YC, Ren R, Hu H	38177682	2023-11-29	56200
Gi/o	αi1	Human	-	61	β1	Human	γ2	Human	Cryo-EM	8W8B	-	3.0	5HT1A	5-HT_1A	5-Hydroxytryptamine	A (Rhodopsin)	Human	BRIL	scFv16	-	ulotaront pubchem gtoplig drugbank chembl_ligand pubchem	small-molecule	Agonist	5-hydroxytryptamine	small-molecule	Liu H, Zheng Y, Wang Y, Wang Y, He X, Xu P, Huang S, Yuan Q, Zhang X, Wang L, Jiang K, Chen H, Li Z, Liu W, Wang S, Xu HE, Xu F	10.1038/S41586-023-06775-1	2023-11-22	56200
Gq/11	αq	Human	Gi2-mini-Gq chimera	58	β1	Human	γ2	Human	Cryo-EM	8WPU	-	3.1	CASR	CaS	Calcium-sensing	C (Glutamate)	Human	-	scFv16	-	cinacalcet pubchem gtoplig chembl_ligand drugbank drug_central pubchem Calcium pubchem	small-molecule small-molecule	Agonist	Mg²⁺, L-tryptophan, spermine, Ca²⁺	small-molecule	Ling S, Meng X, Zhang Y, Xia Z, Zhou Y, Yang F, Shi P, Shi C, Tian C	10.1038/S41422-023-00892-2	2023-11-22	56208
Gs	αs	Human	-	59	β1	Human	γ2	Human	Cryo-EM	8W87	-	2.8	TAAR1	TA₁	Trace amine	A (Rhodopsin)	Human	-	Nanobody-35	-	METHAMPHETAMINE chembl_ligand pubchem	small-molecule	Agonist	tyramine, (+)-Octopamine, octopamine, β-phenylethylamine, CHEMBL1160703, 3-iodothyronamine, dopamine	small-molecule	Liu H, Zheng Y, Wang Y, Wang Y, He X, Xu P, Huang S, Yuan Q, Zhang X, Wang L, Jiang K, Chen H, Li Z, Liu W, Wang S, Xu HE, Xu F	10.1038/S41586-023-06775-1	2023-11-22	56198
Gs	αs	Human	-	60	β1	Human	γ2	Human	Cryo-EM	8W8A	-	2.8	TAAR1	TA₁	Trace amine	A (Rhodopsin)	Human	-	Nanobody-35	-	CHEMBL3684869 chembl_ligand pubchem	small-molecule	Agonist	tyramine, (+)-Octopamine, octopamine, β-phenylethylamine, CHEMBL1160703, 3-iodothyronamine, dopamine	small-molecule	Liu H, Zheng Y, Wang Y, Wang Y, He X, Xu P, Huang S, Yuan Q, Zhang X, Wang L, Jiang K, Chen H, Li Z, Liu W, Wang S, Xu HE, Xu F	10.1038/S41586-023-06775-1	2023-11-22	56198
Gs	αs	Human	-	60	β1	Human	γ2	Human	Cryo-EM	8W89	-	3.0	TAAR1	TA₁	Trace amine	A (Rhodopsin)	Human	-	Nanobody-35	-	2-Phenylethanaminium pubchem	small-molecule	Agonist	tyramine, (+)-Octopamine, octopamine, β-phenylethylamine, CHEMBL1160703, 3-iodothyronamine, dopamine	small-molecule	Liu H, Zheng Y, Wang Y, Wang Y, He X, Xu P, Huang S, Yuan Q, Zhang X, Wang L, Jiang K, Chen H, Li Z, Liu W, Wang S, Xu HE, Xu F	10.1038/S41586-023-06775-1	2023-11-22	56198
Gs	αs	Human	-	60	β1	Human	γ2	Human	Cryo-EM	8W88	-	2.6	TAAR1	TA₁	Trace amine	A (Rhodopsin)	Human	-	Nanobody-35	-	ulotaront pubchem gtoplig drugbank chembl_ligand pubchem	small-molecule	Agonist	tyramine, (+)-Octopamine, octopamine, β-phenylethylamine, CHEMBL1160703, 3-iodothyronamine, dopamine	small-molecule	Liu H, Zheng Y, Wang Y, Wang Y, He X, Xu P, Huang S, Yuan Q, Zhang X, Wang L, Jiang K, Chen H, Li Z, Liu W, Wang S, Xu HE, Xu F	10.1038/S41586-023-06775-1	2023-11-22	56198
Gi/o	αi1	Human	-	61	β1	Human	γ2	Human	Cryo-EM	8JSP	-	3.7	5HT1A	5-HT_1A	5-Hydroxytryptamine	A (Rhodopsin)	Human	-	scFv16	-	ulotaront pubchem gtoplig drugbank chembl_ligand pubchem	small-molecule	Agonist	5-hydroxytryptamine	small-molecule	Xu Z, Guo L, Yu J, Shen S, Wu C, Zhang W, Zhao C, Deng Y, Tian X, Feng Y, Hou H, Su L, Wang H, Guo S, Wang H, Wang K, Chen P, Zhao J, Zhang X, Yong X, Cheng L, Liu L, Yang S, Yang F, Wang X, Yu X, Xu Y, Sun JP, Yan W, Shao Z	10.1038/S41586-023-06804-Z	2023-11-15	56200
Gs	αs	Human	-	58	β1	Human	γ2	Human	Cryo-EM	8JLQ	-	2.8	TAAR1	TA₁	Trace amine	A (Rhodopsin)	Human	BRIL	scFv16	-	fenoldopam pubchem gtoplig chembl_ligand drugbank drug_central pubchem gtoplig chembl_ligand pubchem pubchem gtoplig chembl_ligand pubchem pubchem	small-molecule	Agonist	tyramine, (+)-Octopamine, octopamine, β-phenylethylamine, CHEMBL1160703, 3-iodothyronamine, dopamine	small-molecule	Xu Z, Guo L, Yu J, Shen S, Wu C, Zhang W, Zhao C, Deng Y, Tian X, Feng Y, Hou H, Su L, Wang H, Guo S, Wang H, Wang K, Chen P, Zhao J, Zhang X, Yong X, Cheng L, Liu L, Yang S, Yang F, Wang X, Yu X, Xu Y, Sun JP, Yan W, Shao Z	10.1038/S41586-023-06804-Z	2023-11-15	56198
Gs	αs	Human	-	59	β1	Human	γ2	Human	Cryo-EM	8JLJ	-	3.1	TAAR1	TA₁	Trace amine	A (Rhodopsin)	Mouse	BRIL	scFv16	-	CHEMBL1182312 chembl_ligand chembl_ligand pubchem	small-molecule	Agonist	tyramine, β-phenylethylamine, 3-iodothyronamine	small-molecule	Xu Z, Guo L, Yu J, Shen S, Wu C, Zhang W, Zhao C, Deng Y, Tian X, Feng Y, Hou H, Su L, Wang H, Guo S, Wang H, Wang K, Chen P, Zhao J, Zhang X, Yong X, Cheng L, Liu L, Yang S, Yang F, Wang X, Yu X, Xu Y, Sun JP, Yan W, Shao Z	10.1038/S41586-023-06804-Z	2023-11-15	56198
Gs	αs	Human	-	59	β1	Human	γ2	Mouse	Cryo-EM	8JSO	8JSO_refined	3.4	TAAR1	TA₁	Trace amine	A (Rhodopsin)	Human	BRIL	scFv16	-	dexamfetamine pubchem gtoplig chembl_ligand drugbank drug_central	small-molecule	Agonist	tyramine, (+)-Octopamine, octopamine, β-phenylethylamine, CHEMBL1160703, 3-iodothyronamine, dopamine	small-molecule	Xu Z, Guo L, Yu J, Shen S, Wu C, Zhang W, Zhao C, Deng Y, Tian X, Feng Y, Hou H, Su L, Wang H, Guo S, Wang H, Wang K, Chen P, Zhao J, Zhang X, Yong X, Cheng L, Liu L, Yang S, Yang F, Wang X, Yu X, Xu Y, Sun JP, Yan W, Shao Z	10.1038/S41586-023-06804-Z	2023-11-15	56198
Gs	αs	Human	-	59	β1	Human	γ2	Human	Cryo-EM	8JLK	-	3.2	TAAR1	TA₁	Trace amine	A (Rhodopsin)	Mouse	-	scFv16	-	ulotaront pubchem gtoplig drugbank chembl_ligand pubchem	small-molecule	Agonist	tyramine, β-phenylethylamine, 3-iodothyronamine	small-molecule	Xu Z, Guo L, Yu J, Shen S, Wu C, Zhang W, Zhao C, Deng Y, Tian X, Feng Y, Hou H, Su L, Wang H, Guo S, Wang H, Wang K, Chen P, Zhao J, Zhang X, Yong X, Cheng L, Liu L, Yang S, Yang F, Wang X, Yu X, Xu Y, Sun JP, Yan W, Shao Z	10.1038/S41586-023-06804-Z	2023-11-15	56198
Gs	αs	Human	-	61	β1	Human	γ2	Human	Cryo-EM	8JLP	-	3.2	TAAR1	TA₁	Trace amine	A (Rhodopsin)	Human	-	-	-	ralmitaront pubchem gtoplig chembl_ligand	small-molecule	Agonist	tyramine, (+)-Octopamine, octopamine, β-phenylethylamine, CHEMBL1160703, 3-iodothyronamine, dopamine	small-molecule	Xu Z, Guo L, Yu J, Shen S, Wu C, Zhang W, Zhao C, Deng Y, Tian X, Feng Y, Hou H, Su L, Wang H, Guo S, Wang H, Wang K, Chen P, Zhao J, Zhang X, Yong X, Cheng L, Liu L, Yang S, Yang F, Wang X, Yu X, Xu Y, Sun JP, Yan W, Shao Z	10.1038/S41586-023-06804-Z	2023-11-15	56198
Gs	αs	Human	-	61	β1	Human	γ2	Human	Cryo-EM	8JLN	-	3.2	TAAR1	TA₁	Trace amine	A (Rhodopsin)	Human	BRIL	scFv16	-	CHEMBL1182312 chembl_ligand chembl_ligand pubchem	small-molecule	Agonist	tyramine, (+)-Octopamine, octopamine, β-phenylethylamine, CHEMBL1160703, 3-iodothyronamine, dopamine	small-molecule	Xu Z, Guo L, Yu J, Shen S, Wu C, Zhang W, Zhao C, Deng Y, Tian X, Feng Y, Hou H, Su L, Wang H, Guo S, Wang H, Wang K, Chen P, Zhao J, Zhang X, Yong X, Cheng L, Liu L, Yang S, Yang F, Wang X, Yu X, Xu Y, Sun JP, Yan W, Shao Z	10.1038/S41586-023-06804-Z	2023-11-15	56198
Gs	αs	Human	-	61	β1	Human	γ2	Human	Cryo-EM	8JLO	-	3.5	TAAR1	TA₁	Trace amine	A (Rhodopsin)	Human	-	-	-	ulotaront pubchem gtoplig drugbank chembl_ligand pubchem	small-molecule	Agonist	tyramine, (+)-Octopamine, octopamine, β-phenylethylamine, CHEMBL1160703, 3-iodothyronamine, dopamine	small-molecule	Xu Z, Guo L, Yu J, Shen S, Wu C, Zhang W, Zhao C, Deng Y, Tian X, Feng Y, Hou H, Su L, Wang H, Guo S, Wang H, Wang K, Chen P, Zhao J, Zhang X, Yong X, Cheng L, Liu L, Yang S, Yang F, Wang X, Yu X, Xu Y, Sun JP, Yan W, Shao Z	10.1038/S41586-023-06804-Z	2023-11-15	56198
Gs	αs	Human	-	59	β1	Human	γ2	Human	Cryo-EM	8JLR	-	3.0	TAAR1	TA₁	Trace amine	A (Rhodopsin)	Human	BRIL	scFv16	-	(1~{S},3~{R})-3-(1-adamantyl)-1-(aminomethyl)-3,4-dihydro-1~{H}-isochromene-5,6-diol pubchem	small-molecule	Agonist	tyramine, (+)-Octopamine, octopamine, β-phenylethylamine, CHEMBL1160703, 3-iodothyronamine, dopamine	small-molecule	Xu Z, Guo L, Yu J, Shen S, Wu C, Zhang W, Zhao C, Deng Y, Tian X, Feng Y, Hou H, Su L, Wang H, Guo S, Wang H, Wang K, Chen P, Zhao J, Zhang X, Yong X, Cheng L, Liu L, Yang S, Yang F, Wang X, Yu X, Xu Y, Sun JP, Yan W, Shao Z	10.1038/S41586-023-06804-Z	2023-11-15	56198
Gs	αs	Human	-	55	β1	Human	γ2	Human	Cryo-EM	8U26	8U26_refined	2.5	NK1R	NK₁	Tachykinin	A (Rhodopsin)	Human	-	Nanobody-35	-	substance P pubchem gtoplig chembl_ligand gtoplig gtoplig	peptide	Agonist	neurokinin A, neuropeptide K, hemokinin 1, neurokinin B, neuropeptide-γ, substance P	peptide	Chen M, Schmid MF, Chiu W	10.1038/S41592-023-02082-9	2023-11-15	56198
Gi/o	αi1	Human	-	63	β1	Human	γ2	Human	Cryo-EM	8WRB	-	2.9	GPR34	GPR34	A orphans	A (Rhodopsin)	Human	-	scFv16	-	LYSOPHOSPHATIDIC ACID chembl_ligand pubchem	small-molecule	Agonist	lysophosphatidylserine	small-molecule	Liu G, Li X, Wang Y, Zhang X, Gong W	10.1371/JOURNAL.PBIO.3002387	2023-11-08	56200
Gs	αs	Human	-	60	β1	Rat	γ2	Bovine	Cryo-EM	8JIS	8JIS_refined	2.5	GLP1R	GLP-1	Glucagon	B1 (Secretin)	Human	-	Nanobody-35	-	Dual-agonist peptide P15	peptide	Agonist	glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37)	peptide	Li Y, Zhou Q, Dai A, Zhao F, Chang R, Ying T, Wu B, Yang D, Wang MW, Cong Z	10.1073/PNAS.2303696120	2023-11-08	56198
Gi/o	αi1	Human	-	63	β1	Human	γ2	Human	Cryo-EM	8G05	-	3.0	GPR84	GPR84	A orphans	A (Rhodopsin)	Human	-	scFv16	-	6-Octylimino-1,3-diazinane-2,4-dione pubchem	lipid	Agonist	-	-	Zhang X, Wang Y, Supekar S, Cao X, Zhou J, Dang J, Chen S, Jenkins L, Marsango S, Li X, Liu G, Milligan G, Feng M, Fan H, Gong W, Zhang C	10.1038/S41467-023-41201-0	2023-11-01	56200
Gi/o	αi1	Human	-	61	β1	Human	γ2	Human	Cryo-EM	8SG1	-	2.9	CML1	chemerin	Chemerin receptor	A (Rhodopsin)	Human	-	scFv16	-	chemerin C-terminal peptide pubchem gtoplig chembl_ligand pubchem	peptide	Agonist	18R-HEPE, resolvin E1, chemerin C-terminal peptide, chemerin, EPA	peptide	Zhang X, Weiss T, Cheng MH, Chen S, Ambrosius CK, Czerniak AS, Li K, Feng M, Bahar I, Beck-Sickinger AG, Zhang C	10.1371/JOURNAL.PBIO.3002188	2023-11-01	56200
Gs	αs	Human	-	60	β1	Human	γ2	Human	Cryo-EM	8IZB	-	3.1	GP174	GPR174	A orphans	A (Rhodopsin)	Human	-	Nanobody-35	-	LYSOPHOSPHATIDIC ACID chembl_ligand pubchem L-serine pubchem gtoplig chembl_ligand drugbank drug_central pubchem	small-molecule small-molecule	Agonist	lysophosphatidylserine	small-molecule	Liu G, Li X, Wang Y, Zhang X, Gong W	10.1371/JOURNAL.PBIO.3002387	2023-11-01	56198
Gi/o	αi1	Human	-	61	β1	Human	γ2	Human	Cryo-EM	8K4N	8K4N_refined	2.8	GPR34	GPR34	A orphans	A (Rhodopsin)	Human	-	scFv16	-	(2R)-2-azanyl-3-[oxidanyl-[(2R)-2-oxidanyl-3-tetradec-9-enoyloxy-propoxy]phosphoryl]oxy-propanoic acid pubchem	small-molecule	Agonist	lysophosphatidylserine	small-molecule	-	-	2023-10-25	56200
Gq/11	αq	Human	-	62	β1	Human	γ2	Human	Cryo-EM	7YFC	-	3.0	HRH4	H₄	Histamine	A (Rhodopsin)	Human	-	scFv16 Nanobody-35	-	histamine pubchem gtoplig chembl_ligand drug_central drugbank gtoplig pubchem	small-molecule	Agonist	histamine, CCL16	small-molecule	Im D, Kishikawa JI, Shiimura Y, Hisano H, Ito A, Fujita-Fujiharu Y, Sugita Y, Noda T, Kato T, Asada H, Iwata S	10.1038/S41467-023-42260-Z	2023-10-25	56208
Gq/11	αq	Human	-	62	β1	Human	γ2	Human	Cryo-EM	7YFD	-	3.1	HRH4	H₄	Histamine	A (Rhodopsin)	Human	-	scFv16 Nanobody-35	-	imetit pubchem gtoplig chembl_ligand pubchem	small-molecule	Agonist	histamine, CCL16	small-molecule	Im D, Kishikawa JI, Shiimura Y, Hisano H, Ito A, Fujita-Fujiharu Y, Sugita Y, Noda T, Kato T, Asada H, Iwata S	10.1038/S41467-023-42260-Z	2023-10-25	56208
Gi/o	αo	Human	-	59	β1	Human	γ2	Human	Cryo-EM	8J6D	8J6D_refined	3.1	C3AR	C3a	Complement peptide	A (Rhodopsin)	Human	-	scFv16	-	EP141 peptide agonist	peptide	Agonist	C5a, C3a	peptide	Yadav MK, Maharana J, Yadav R, Saha S, Sarma P, Soni C, Singh V, Saha S, Ganguly M, Li XX, Mohapatra S, Mishra S, Khant HA, Chami M, Woodruff TM, Banerjee R, Shukla AK, Gati C	10.1016/J.CELL.2023.09.020	2023-10-18	56206
Gi/o	αo	Human	-	58	β1	Human	γ2	Human	Cryo-EM	8HPT	-	3.4	C5AR1	C5a₁	Complement peptide	A (Rhodopsin)	Mouse	-	scFv16	-	C5a	peptide	Agonist	-	-	None	HTTPS://DOI.ORG/10.1016/J.CELL.2023.09.020	2023-10-18	56206
Gi/o	αo	Human	-	59	β1	Human	γ2	Human	Cryo-EM	8I9S	8I9S_refined	3.3	C3AR	C3a	Complement peptide	A (Rhodopsin)	Human	-	scFv16	-	Apo (no ligand)	none	Apo (no ligand)	C5a, C3a	peptide	Yadav MK, Maharana J, Yadav R, Saha S, Sarma P, Soni C, Singh V, Saha S, Ganguly M, Li XX, Mohapatra S, Mishra S, Khant HA, Chami M, Woodruff TM, Banerjee R, Shukla AK, Gati C	10.1016/J.CELL.2023.09.020	2023-10-18	56206
Gi/o	αo	Human	-	60	β1	Human	γ2	Human	Cryo-EM	8HQC	-	3.9	C5AR1	C5a₁	Complement peptide	A (Rhodopsin)	Mouse	-	-	fragment	C5a gtoplig	peptide	Agonist	-	-	None	HTTPS://DOI.ORG/10.1016/J.CELL.2023.09.020	2023-10-18	56206
Gi/o	αo	Human	-	59	β1	Human	γ2	Human	Cryo-EM	8JZZ	8JZZ_refined	3.3	C5AR1	C5a₁	Complement peptide	A (Rhodopsin)	Human	-	scFv16	-	C5a des-Arg gtoplig	peptide	Agonist	C5a, ribosomal protein S19, C5a des-Arg, C3a	peptide	Yadav MK, Maharana J, Yadav R, Saha S, Sarma P, Soni C, Singh V, Saha S, Ganguly M, Li XX, Mohapatra S, Mishra S, Khant HA, Chami M, Woodruff TM, Banerjee R, Shukla AK, Gati C	10.1016/J.CELL.2023.09.020	2023-10-18	56206
Gi/o	αo	Human	-	59	β1	Human	γ2	Human	Cryo-EM	8I97	8I97_refined	3.2	C3AR	C3a	Complement peptide	A (Rhodopsin)	Human	-	scFv16	-	Apo (no ligand)	none	Apo (no ligand)	C5a, C3a	peptide	Yadav MK, Maharana J, Yadav R, Saha S, Sarma P, Soni C, Singh V, Saha S, Ganguly M, Li XX, Mohapatra S, Mishra S, Khant HA, Chami M, Woodruff TM, Banerjee R, Shukla AK, Gati C	10.1016/J.CELL.2023.09.020	2023-10-18	56206
Gi/o	αo	Human	-	59	β1	Human	γ2	Human	Cryo-EM	8I9L	-	3.2	C3AR	C3a	Complement peptide	A (Rhodopsin)	Human	-	scFv16	-	C3a anaphylatoxin pubchem	peptide	Agonist	C5a, C3a	peptide	Yadav MK, Maharana J, Yadav R, Saha S, Sarma P, Soni C, Singh V, Saha S, Ganguly M, Li XX, Mohapatra S, Mishra S, Khant HA, Chami M, Woodruff TM, Banerjee R, Shukla AK, Gati C	10.1016/J.CELL.2023.09.020	2023-10-18	56206
Gi/o	αo	Human	-	59	β1	Human	γ2	Human	Cryo-EM	8I95	-	2.9	C3AR	C3a	Complement peptide	A (Rhodopsin)	Human	-	scFv16	-	EP54 ligand	peptide	Agonist	C5a, C3a	peptide	Yadav MK, Maharana J, Yadav R, Saha S, Sarma P, Soni C, Singh V, Saha S, Ganguly M, Li XX, Mohapatra S, Mishra S, Khant HA, Chami M, Woodruff TM, Banerjee R, Shukla AK, Gati C	10.1016/J.CELL.2023.09.020	2023-10-18	56206
Gi/o	αo	Human	-	59	β1	Human	γ2	Human	Cryo-EM	8IA2	8IA2_refined	3.2	C5AR1	C5a₁	Complement peptide	A (Rhodopsin)	Human	-	scFv16	-	C5a gtoplig	peptide	Agonist	C5a, ribosomal protein S19, C5a des-Arg, C3a	peptide	Yadav MK, Maharana J, Yadav R, Saha S, Sarma P, Soni C, Singh V, Saha S, Ganguly M, Li XX, Mohapatra S, Mishra S, Khant HA, Chami M, Woodruff TM, Banerjee R, Shukla AK, Gati C	10.1016/J.CELL.2023.09.020	2023-10-18	56206
Gq/11	αq	Human	-	58	β1	Human	γ2	Human	Cryo-EM	8I9A	-	3.6	C3AR	C3a	Complement peptide	A (Rhodopsin)	Human	-	scFv16	-	EP54 ligand	peptide	Agonist	C5a, C3a	peptide	Yadav MK, Maharana J, Yadav R, Saha S, Sarma P, Soni C, Singh V, Saha S, Ganguly M, Li XX, Mohapatra S, Mishra S, Khant HA, Chami M, Woodruff TM, Banerjee R, Shukla AK, Gati C	10.1016/J.CELL.2023.09.020	2023-10-18	56208
Gs	αs	Bovine	-	59	β1	Rat	γ2	Bovine	Cryo-EM	8ITL	-	3.2	GIPR	GIP	Glucagon	B1 (Secretin)	Human	-	Nanobody-35	-	Apo (no ligand)	none	Apo (no ligand)	gastric inhibitory polypeptide	peptide	Zhao F, Hang K, Zhou Q, Shao L, Li H, Li W, Lin S, Dai A, Cai X, Liu Y, Xu Y, Feng W, Yang D, Wang MW	10.1073/PNAS.2306145120	2023-10-18	56215
Gs	αs	Bovine	-	59	β1	Rat	γ2	Bovine	Cryo-EM	8ITM	-	3.1	GIPR	GIP	Glucagon	B1 (Secretin)	Human	-	Nanobody-35	-	Apo (no ligand)	none	Apo (no ligand)	gastric inhibitory polypeptide	peptide	Zhao F, Hang K, Zhou Q, Shao L, Li H, Li W, Lin S, Dai A, Cai X, Liu Y, Xu Y, Feng W, Yang D, Wang MW	10.1073/PNAS.2306145120	2023-10-18	56215
Gs	αs	Human	-	58	β1	Human	γ2	Human	Cryo-EM	8KH5	-	2.8	GP174	GPR174	A orphans	A (Rhodopsin)	Human	-	Nanobody-35	-	Lysophosphotidylserine pubchem	small-molecule	Agonist	lysophosphatidylserine	small-molecule	Nie Y, Qiu Z, Chen S, Chen Z, Song X, Ma Y, Huang N, Cyster JG, Zheng S	10.1038/S41467-023-41654-3	2023-10-18	56198
Gi/o	αi1	Human	-	60	β1	Human	γ2	Human	Cryo-EM	8HQN	8HQN_refined	3.0	GP132	GPR132	A orphans	A (Rhodopsin)	Human	BRIL	scFv16	-	9-hydroxyoctadecadienoic acid pubchem gtoplig chembl_ligand drugbank	small-molecule	Agonist	9-hydroxyoctadecadienoic acid	small-molecule	Wang JL, Dou XD, Cheng J, Gao MX, Xu GF, Ding W, Ding JH, Li Y, Wang SH, Ji ZW, Zhao XY, Huo TY, Zhang CF, Liu YM, Sha XY, Gao JR, Zhang WH, Hao Y, Zhang C, Sun JP, Jiao N, Yu X	10.1038/S42255-023-00899-4	2023-10-11	56200
Gi/o	αi1	Human	-	60	β1	Human	γ2	Human	Cryo-EM	8HQE	8HQE_refined	3.0	GP132	GPR132	A orphans	A (Rhodopsin)	Human	BRIL	scFv16	-	Apo (no ligand)	none	Apo (no ligand)	9-hydroxyoctadecadienoic acid	small-molecule	Wang JL, Dou XD, Cheng J, Gao MX, Xu GF, Ding W, Ding JH, Li Y, Wang SH, Ji ZW, Zhao XY, Huo TY, Zhang CF, Liu YM, Sha XY, Gao JR, Zhang WH, Hao Y, Zhang C, Sun JP, Jiao N, Yu X	10.1038/S42255-023-00899-4	2023-10-11	56200
Gi/o	αi1	Human	-	60	β1	Human	γ2	Human	Cryo-EM	8HQM	8HQM_refined	3.0	GP132	GPR132	A orphans	A (Rhodopsin)	Human	BRIL	scFv16	-	CHEMBL3354065 chembl_ligand pubchem	small-molecule	Agonist	9-hydroxyoctadecadienoic acid	small-molecule	Wang JL, Dou XD, Cheng J, Gao MX, Xu GF, Ding W, Ding JH, Li Y, Wang SH, Ji ZW, Zhao XY, Huo TY, Zhang CF, Liu YM, Sha XY, Gao JR, Zhang WH, Hao Y, Zhang C, Sun JP, Jiao N, Yu X	10.1038/S42255-023-00899-4	2023-10-11	56200
Gi/o	αi1	Human	-	60	β1	Human	γ2	Human	Cryo-EM	8HVI	8HVI_refined	3.0	GP132	GPR132	A orphans	A (Rhodopsin)	Human	BRIL	scFv16	-	NOX-6-7 pubchem gtoplig	small-molecule	Agonist	9-hydroxyoctadecadienoic acid	small-molecule	Wang JL, Dou XD, Cheng J, Gao MX, Xu GF, Ding W, Ding JH, Li Y, Wang SH, Ji ZW, Zhao XY, Huo TY, Zhang CF, Liu YM, Sha XY, Gao JR, Zhang WH, Hao Y, Zhang C, Sun JP, Jiao N, Yu X	10.1038/S42255-023-00899-4	2023-10-11	56200
Gi/o	αi1	Human	-	63	β1	Human	γ2	Human	Cryo-EM	8H2G	8H2G_refined	3.0	HCAR2	HCA₂	Hydroxycarboxylic acid	A (Rhodopsin)	Human	-	scFv16	-	nicotinic acid pubchem gtoplig chembl_ligand drugbank drug_central gtoplig pubchem	small-molecule	Agonist	butyric acid, β-D-hydroxybutyric acid	small-molecule	-	-	2023-10-11	56200
Gs	αs	Human	-	58	β1	Human	γ2	Human	Cryo-EM	8KGK	8KGK_refined	3.2	GPR61	GPR61	A orphans	A (Rhodopsin)	Human	-	Nanobody-35	-	Apo (no ligand)	none	Apo (no ligand)	-	-	Nie Y, Qiu Z, Chen S, Chen Z, Song X, Ma Y, Huang N, Cyster JG, Zheng S	10.1038/S41467-023-41654-3	2023-10-11	56198
Gs	αs	Human	-	58	β1	Human	γ2	Human	Cryo-EM	8KH4	8KH4_refined	3.1	GP161	GPR161	A orphans	A (Rhodopsin)	Human	-	Nanobody-35	-	Apo (no ligand)	none	Apo (no ligand)	-	-	Nie Y, Qiu Z, Chen S, Chen Z, Song X, Ma Y, Huang N, Cyster JG, Zheng S	10.1038/S41467-023-41654-3	2023-10-11	56198
Gi/o	αi1	Human	-	64	β1	Human	γ2	Human	Cryo-EM	8SAI	8SAI_refined	3.3	GPR34	GPR34	A orphans	A (Rhodopsin)	Human	-	scFv16	-	O-[(S)-Hydroxy{[(2s)-2-Hydroxy-3-(Octadec-9-Enoyloxy)propyl]oxy}phosphoryl]-L-Serine pubchem	small-molecule	Agonist	lysophosphatidylserine	small-molecule	Xia A, Yong X, Zhang C, Lin G, Jia G, Zhao C, Wang X, Hao Y, Wang Y, Zhou P, Yang X, Deng Y, Wu C, Chen Y, Zhu J, Tang X, Liu J, Zhang S, Zhang J, Xu Z, Hu Q, Zhao J, Yue Y, Yan W, Su Z, Wei Y, Zhou R, Dong H, Shao Z, Yang S	10.1073/PNAS.2308435120	2023-10-04	56200
Gi/o	αi1	Human	-	64	β1	Human	γ2	Human	Cryo-EM	8JZ7	8JZ7_refined	2.6	HCAR2	HCA₂	Hydroxycarboxylic acid	A (Rhodopsin)	Human	-	scFv16	-	MK 6892 pubchem gtoplig chembl_ligand pubchem	small-molecule	Agonist	butyric acid, β-D-hydroxybutyric acid	small-molecule	Cheng L, Sun S, Wang H, Zhao C, Tian X, Liu Y, Fu P, Shao Z, Chai R, Yan W	10.1038/S41392-023-01625-Y	2023-10-04	56200
Gs	αs	Human	-	56	β1	Human	γ2	Human	Cryo-EM	8TB0	8TB0_refined	3.5	GPR61	GPR61	A orphans	A (Rhodopsin)	Human	-	scFv16	-	Apo (no ligand)	none	Apo (no ligand)	-	-	-	-	2023-10-04	56198
Gs	αs	Human	Gi1-Gs chimera	59	β1	Human	γ2	Bovine	Cryo-EM	8IOD	-	2.6	MC5R	MC₅	Melanocortin	A (Rhodopsin)	Human	-	Nanobody-35	-	PG-901 pubchem	peptide	Agonist	γ-MSH, α-MSH, β-MSH, ACTH, agouti-related protein	peptide	Chen VB, Arendall WB 3rd, Headd JJ, Keedy DA, Immormino RM, Kapral GJ, Murray LW, Richardson JS, Richardson DC	10.1107/S0907444909042073	2023-09-20	56198
Gs	αs	Human	Gi1-Gs chimera	60	β1	Human	γ2	Bovine	Cryo-EM	8INR	-	2.7	MC5R	MC₅	Melanocortin	A (Rhodopsin)	Human	-	-	-	INTERMEDINE chembl_ligand pubchem pubchem pubchem	protein	Agonist	γ-MSH, α-MSH, β-MSH, ACTH, agouti-related protein	peptide	Chen VB, Arendall WB 3rd, Headd JJ, Keedy DA, Immormino RM, Kapral GJ, Murray LW, Richardson JS, Richardson DC	10.1107/S0907444909042073	2023-09-20	56198
Gs	αs	Human	Gi1-Gs chimera	60	β1	Human	γ2	Bovine	Cryo-EM	8IOC	-	2.9	MC3R	MC₃	Melanocortin	A (Rhodopsin)	Human	-	Nanobody-35	-	γ-MSH pubchem gtoplig pubchem	peptide	Agonist	γ-MSH, α-MSH, β-MSH, ACTH, agouti-related protein	peptide	Chen VB, Arendall WB 3rd, Headd JJ, Keedy DA, Immormino RM, Kapral GJ, Murray LW, Richardson JS, Richardson DC	10.1107/S0907444909042073	2023-09-20	56198
Gi/o	αi1	Human	-	62	β1	Mouse	γ2	Mouse	Cryo-EM	8IHB	-	2.9	HCAR2	HCA₂	Hydroxycarboxylic acid	A (Rhodopsin)	Human	BRIL	-	-	GSK256073 pubchem gtoplig chembl_ligand	small-molecule	Agonist	butyric acid, β-D-hydroxybutyric acid	small-molecule	Suzuki S, Tanaka K, Nishikawa K, Suzuki H, Oshima A, Fujiyoshi Y	10.1038/S41467-023-41650-7	2023-09-13	56200
Gi/o	αi1	Mouse	-	64	β1	Human	γ2	Human	Cryo-EM	8FX5	-	2.5	ACM4	M₄	Acetylcholine (muscarinic)	A (Rhodopsin)	Human	-	scFv16	-	xanomeline pubchem gtoplig chembl_ligand drug_central drugbank pubchem	small-molecule	Agonist	acetylcholine	small-molecule	Burger WAC, Pham V, Vuckovic Z, Powers AS, Mobbs JI, Laloudakis Y, Glukhova A, Wootten D, Tobin AB, Sexton PM, Paul SM, Felder CC, Danev R, Dror RO, Christopoulos A, Valant C, Thal DM	10.1038/S41467-023-41199-5	2023-09-13	56242
Gs	αs	Human	-	56	β1	Rat	γ2	Bovine	Cryo-EM	8JIQ	8JIQ_refined	3.4	GLR	glucagon	Glucagon	B1 (Secretin)	Human	-	Nanobody-35	-	Dual-agonist peptide P15	peptide	Agonist	glucagon	peptide	-	-	2023-09-13	56198
Gs	αs	Human	-	59	β1	Rat	γ2	Bovine	Cryo-EM	8JIU	8JIU_refined	2.8	GLR	glucagon	Glucagon	B1 (Secretin)	Human	-	Nanobody-35	-	SAR425899	peptide	Agonist	glucagon	peptide	Li Y, Zhou Q, Dai A, Zhao F, Chang R, Ying T, Wu B, Yang D, Wang MW, Cong Z	10.1073/PNAS.2303696120	2023-09-13	56198
Gi/o	αi1	Human	-	64	β1	Human	γ2	Human	Cryo-EM	8JIM	-	3.0	HCAR2	HCA₂	Hydroxycarboxylic acid	A (Rhodopsin)	Human	-	scFv16	-	CHEMBL3354065 chembl_ligand pubchem	small-molecule	Agonist	butyric acid, β-D-hydroxybutyric acid	small-molecule	Zhao C, Wang H, Liu Y, Cheng L, Wang B, Tian X, Fu H, Wu C, Li Z, Shen C, Yu J, Yang S, Hu H, Fu P, Ma L, Wang C, Yan W, Shao Z	10.1016/J.MOLCEL.2023.07.030	2023-09-06	56200
Gi/o	αi1	Human	-	64	β1	Human	γ2	Human	Cryo-EM	8JII	-	3.2	HCAR2	HCA₂	Hydroxycarboxylic acid	A (Rhodopsin)	Human	-	scFv16	-	nicotinic acid pubchem gtoplig chembl_ligand drugbank drug_central gtoplig pubchem compound 9n [PMID: 18752940] pubchem gtoplig chembl_ligand	small-molecule small-molecule	Agonist PAM	butyric acid, β-D-hydroxybutyric acid	small-molecule	Zhao C, Wang H, Liu Y, Cheng L, Wang B, Tian X, Fu H, Wu C, Li Z, Shen C, Yu J, Yang S, Hu H, Fu P, Ma L, Wang C, Yan W, Shao Z	10.1016/J.MOLCEL.2023.07.030	2023-09-06	56200
Gi/o	αi1	Human	-	64	β1	Human	γ2	Human	Cryo-EM	8JHY	-	2.9	HCAR2	HCA₂	Hydroxycarboxylic acid	A (Rhodopsin)	Human	-	scFv16	-	compound 9n [PMID: 18752940] pubchem gtoplig chembl_ligand	small-molecule	PAM	butyric acid, β-D-hydroxybutyric acid	small-molecule	Zhao C, Wang H, Liu Y, Cheng L, Wang B, Tian X, Fu H, Wu C, Li Z, Shen C, Yu J, Yang S, Hu H, Fu P, Ma L, Wang C, Yan W, Shao Z	10.1016/J.MOLCEL.2023.07.030	2023-09-06	56200
Gi/o	αi1	Human	-	63	β1	Human	γ2	Human	Cryo-EM	8JIL	-	3.5	HCAR2	HCA₂	Hydroxycarboxylic acid	A (Rhodopsin)	Human	-	scFv16	-	nicotinic acid pubchem gtoplig chembl_ligand drugbank drug_central gtoplig pubchem	small-molecule	Agonist	butyric acid, β-D-hydroxybutyric acid	small-molecule	Zhao C, Wang H, Liu Y, Cheng L, Wang B, Tian X, Fu H, Wu C, Li Z, Shen C, Yu J, Yang S, Hu H, Fu P, Ma L, Wang C, Yan W, Shao Z	10.1016/J.MOLCEL.2023.07.030	2023-09-06	56200
Gs	αs	Human	-	62	β1	Rat	γ2	Bovine	Cryo-EM	8JIP	8JIP_refined	2.9	GLP1R	GLP-1	Glucagon	B1 (Secretin)	Human	-	Nanobody-35	-	MEDI0382	peptide	Agonist	glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37)	peptide	Li Y, Zhou Q, Dai A, Zhao F, Chang R, Ying T, Wu B, Yang D, Wang MW, Cong Z	10.1073/PNAS.2303696120	2023-09-06	56198
Gs	αs	Human	-	58	β1	Rat	γ2	Bovine	Cryo-EM	8JIR	8JIR_refined	2.6	GLP1R	GLP-1	Glucagon	B1 (Secretin)	Human	-	Nanobody-35	-	SAR425899	peptide	Agonist	glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37)	peptide	Li Y, Zhou Q, Dai A, Zhao F, Chang R, Ying T, Wu B, Yang D, Wang MW, Cong Z	10.1073/PNAS.2303696120	2023-09-06	56198
Gs	αs	Human	-	58	β1	Rat	γ2	Bovine	Cryo-EM	8JIT	-	2.9	GLR	glucagon	Glucagon	B1 (Secretin)	Human	-	Nanobody-35	-	MEDI0382	peptide	Agonist	glucagon	peptide	Li Y, Zhou Q, Dai A, Zhao F, Chang R, Ying T, Wu B, Yang D, Wang MW, Cong Z	10.1073/PNAS.2303696120	2023-09-06	56198
Gi/o	αi1	Human	-	62	β1	Mouse	γ2	Mouse	Cryo-EM	8IHI	-	3.1	HCAR2	HCA₂	Hydroxycarboxylic acid	A (Rhodopsin)	Human	BRIL	scFv16	-	(5S)-5-methyl-4-oxo-5-phenylfuran-2-carboxylic acid pubchem	small-molecule	Agonist	butyric acid, β-D-hydroxybutyric acid	small-molecule	Suzuki S, Tanaka K, Nishikawa K, Suzuki H, Oshima A, Fujiyoshi Y	10.1038/S41467-023-41650-7	2023-08-30	56200
Gi/o	αi1	Human	-	62	β1	Mouse	γ2	Mouse	Cryo-EM	8IHF	-	3.0	HCAR2	HCA₂	Hydroxycarboxylic acid	A (Rhodopsin)	Human	BRIL	scFv16	-	MK 6892 pubchem gtoplig chembl_ligand pubchem	small-molecule	Agonist	butyric acid, β-D-hydroxybutyric acid	small-molecule	Suzuki S, Tanaka K, Nishikawa K, Suzuki H, Oshima A, Fujiyoshi Y	10.1038/S41467-023-41650-7	2023-08-30	56200
Gi/o	αi1	Human	-	62	β1	Mouse	γ2	Mouse	Cryo-EM	8IHH	-	3.1	HCAR2	HCA₂	Hydroxycarboxylic acid	A (Rhodopsin)	Human	BRIL	scFv16	-	5-butyl-1H-pyrazole-3-carboxylic acid pubchem gtoplig chembl_ligand	small-molecule	Agonist	butyric acid, β-D-hydroxybutyric acid	small-molecule	Suzuki S, Tanaka K, Nishikawa K, Suzuki H, Oshima A, Fujiyoshi Y	10.1038/S41467-023-41650-7	2023-08-30	56200
Gi/o	αi1	Human	-	62	β1	Mouse	γ2	Mouse	Cryo-EM	8IHJ	8IHJ_refined	3.1	HCAR3	HCA₃	Hydroxycarboxylic acid	A (Rhodopsin)	Human	BRIL	scFv16	-	(5S)-5-methyl-4-oxo-5-phenylfuran-2-carboxylic acid pubchem	small-molecule	Agonist	3-hydroxyoctanoic acid	small-molecule	Suzuki S, Tanaka K, Nishikawa K, Suzuki H, Oshima A, Fujiyoshi Y	10.1038/S41467-023-41650-7	2023-08-30	56200
Gi/o	αi1	Human	-	62	β1	Rat	γ2	Bovine	Cryo-EM	8IY5	-	2.8	EDNRB	ET_B	Endothelin	A (Rhodopsin)	Human	-	scFv16	-	ENDOTHELIN chembl_ligand pubchem	protein	Agonist	endothelin-2, endothelin-3, endothelin-1	peptide	Sano FK, Akasaka H, Shihoya W, Nureki O	10.7554/ELIFE.85821	2023-08-16	56200
Gq/11	αq	Human	-	57	β1	Human	γ2	Human	Cryo-EM	8THL	-	3.1	ADA1A	α_1A	Adrenoceptors	A (Rhodopsin)	Human	T4-Lysozyme	scFv16	-	(-)-adrenaline pubchem gtoplig chembl_ligand drugbank drug_central pubchem pubchem	small-molecule	Agonist	(-)-adrenaline, (-)-noradrenaline	small-molecule	Su M, Wang J, Xiang G, Do HN, Levitz J, Miao Y, Huang XY	10.1038/S41467-023-40524-2	2023-08-16	56208
Gq/11	αq	Human	-	57	β1	Human	γ2	Human	Cryo-EM	8THK	-	2.6	ADA1A	α_1A	Adrenoceptors	A (Rhodopsin)	Human	T4-Lysozyme	scFv16	-	CHEMBL133451 chembl_ligand pubchem	small-molecule	Agonist	(-)-adrenaline, (-)-noradrenaline	small-molecule	Su M, Wang J, Xiang G, Do HN, Levitz J, Miao Y, Huang XY	10.1038/S41467-023-40524-2	2023-08-16	56208
Gq/11	αq	Human	GRK2 bound	88	-	-	-	-	Cryo-EM	8JPB	-	3.1	NTR1	NTS₁	Neurotensin	A (Rhodopsin)	Human	-	GRK2	GRK2	JMV431 gtoplig chembl_ligand pubchem CHEMBL4576388 chembl_ligand pubchem	peptide small-molecule	Agonist PAM	large neurotensin, neurotensin, neuromedin N, large neuromedin N	peptide	Duan J, Liu H, Zhao F, Yuan Q, Ji Y, Cai X, He X, Li X, Li J, Wu K, Gao T, Zhu S, Lin S, Wang MW, Cheng X, Yin W, Jiang Y, Yang D, Xu HE	10.1038/S41586-023-06395-9	2023-08-09	56208
Gq/11	αq	Human	-	56	β1	Human	γ2	Human	Cryo-EM	8H0Q	-	3.3	GRPR	BB₂	Bombesin	A (Rhodopsin)	Human	-	-	-	Gastrin-releasing peptide pubchem	peptide	Agonist	gastrin-releasing peptide, neuromedin B, neuromedin C, gastrin releasing peptide(14-27) (human), GRP-(18-27)	peptide	Li C, Xu Y, Liu H, Cai H, Jiang Y, Xu HE, Yin W	10.1038/S41422-022-00743-6	2023-08-09	56208
Gq/11	αq	Human	GRK2 bound	88	-	-	-	-	Cryo-EM	8JPC	-	3.1	NTR1	NTS₁	Neurotensin	A (Rhodopsin)	Human	-	GRK2	GRK2	JMV431 gtoplig chembl_ligand pubchem CHEMBL4576388 chembl_ligand pubchem	peptide small-molecule	Agonist PAM	large neurotensin, neurotensin, neuromedin N, large neuromedin N	peptide	Duan J, Liu H, Zhao F, Yuan Q, Ji Y, Cai X, He X, Li X, Li J, Wu K, Gao T, Zhu S, Lin S, Wang MW, Cheng X, Yin W, Jiang Y, Yang D, Xu HE	10.1038/S41586-023-06395-9	2023-08-09	56208
Gq/11	αq	Human	-	57	β1	Human	γ2	Human	Cryo-EM	8H0P	-	3.2	NMBR	BB₁	Bombesin	A (Rhodopsin)	Human	-	scFv16	-	NMB30	peptide	Agonist	gastrin-releasing peptide, neuromedin B, gastrin releasing peptide(14-27) (human), GRP-(18-27)	peptide	Li C, Xu Y, Liu H, Cai H, Jiang Y, Xu HE, Yin W	10.1038/S41422-022-00743-6	2023-08-09	56208
Gq/11	αq	Human	-	98	-	-	-	-	Cryo-EM	8JPE	-	2.9	-	-	-	-	-	-	-	-	-	-	-	-	-	Duan J, Liu H, Zhao F, Yuan Q, Ji Y, Cai X, He X, Li X, Li J, Wu K, Gao T, Zhu S, Lin S, Wang MW, Cheng X, Yin W, Jiang Y, Yang D, Xu HE	37532940	2023-08-09	56208
Gs	αs	Human	-	58	β1	Human	γ2	Human	Cryo-EM	8PM2	-	2.9	TAA7F	TAAR7F	A orphans	A (Rhodopsin)	Mouse	-	Nanobody-35	-	N,N-Dimethylcyclohexylamine pubchem	small-molecule	Agonist	-	-	Gusach A, Lee Y, Khoshgrudi AN, Mukhaleva E, Ma N, Koers EJ, Chen Q, Edwards PC, Huang F, Kim J, Mancia F, Verprintsev DB, Vaidehi N, Weyand SN, Tate CG	10.1101/2023.07.07.547762	2023-08-09	56198
Gs	αs	Human	-	58	β1	Human	γ2	Human	Cryo-EM	8F0J	-	2.0	CALCR	CT	Calcitonin	B1 (Secretin)	Human	-	Nanobody-35	-	Pramlintide analogue San45	peptide	Agonist	adrenomedullin, calcitonin, β-CGRP, adrenomedullin 2/intermedin, α-CGRP, amylin	peptide	Cao J, Belousoff MJ, Gerrard E, Danev R, Fletcher MM, Dal Maso E, Schreuder H, Lorenz K, Evers A, Tiwari G, Besenius M, Li Z, Johnson RM, Wootten D, Sexton PM	10.1038/S41589-023-01393-4	2023-08-02	56198
Gs	αs	Human	-	59	β1	Human	γ2	Human	Cryo-EM	8JR9	-	2.6	PTH1R	PTH1	Parathyroid hormone	B1 (Secretin)	Human	-	Nanobody-35	-	PCO371 pubchem gtoplig chembl_ligand drugbank	small-molecule	Agonist	PTH, PTHrP, TIP39, PTHrP-(1-36)	peptide	Zhao LH, He Q, Yuan Q, Gu Y, He X, Shan H, Li J, Wang K, Li Y, Hu W, Wu K, Shen J, Xu HE	10.1038/S41586-023-06467-W	2023-08-02	56198
Gs	αs	Human	-	58	β1	Human	γ2	Human	Cryo-EM	8F0K	-	1.9	CALCR	CT	Calcitonin	B1 (Secretin)	Human	-	Nanobody-35 RAMP3	-	San385	peptide	Agonist	adrenomedullin, calcitonin, β-CGRP, adrenomedullin 2/intermedin, α-CGRP, amylin	peptide	Cao J, Belousoff MJ, Gerrard E, Danev R, Fletcher MM, Dal Maso E, Schreuder H, Lorenz K, Evers A, Tiwari G, Besenius M, Li Z, Johnson RM, Wootten D, Sexton PM	10.1038/S41589-023-01393-4	2023-08-02	56198
Gs	αs	Human	-	58	β1	Human	γ2	Human	Cryo-EM	8F2B	-	2.0	CALCR	CT	Calcitonin	B1 (Secretin)	Human	-	Nanobody-35 RAMP3	-	Pramlintide analogue San45	peptide	Agonist	adrenomedullin, calcitonin, β-CGRP, adrenomedullin 2/intermedin, α-CGRP, amylin	peptide	Cao J, Belousoff MJ, Gerrard E, Danev R, Fletcher MM, Dal Maso E, Schreuder H, Lorenz K, Evers A, Tiwari G, Besenius M, Li Z, Johnson RM, Wootten D, Sexton PM	10.1038/S41589-023-01393-4	2023-08-02	56198
Gs	αs	Human	-	59	β1	Human	γ2	Human	Cryo-EM	8F2A	-	2.2	CALCR	CT	Calcitonin	B1 (Secretin)	Human	-	Nanobody-35	-	Pramlintide analogue San385	peptide	Agonist	adrenomedullin, calcitonin, β-CGRP, adrenomedullin 2/intermedin, α-CGRP, amylin	peptide	Cao J, Belousoff MJ, Gerrard E, Danev R, Fletcher MM, Dal Maso E, Schreuder H, Lorenz K, Evers A, Tiwari G, Besenius M, Li Z, Johnson RM, Wootten D, Sexton PM	10.1038/S41589-023-01393-4	2023-08-02	56198
Gi/o	αi1	Human	-	65	β1	Human	γ2	Human	Cryo-EM	8IC0	-	3.4	CXCR1	CXCR1	Chemokine	A (Rhodopsin)	Human	-	scFv16	-	Interleukin-8 pubchem	protein	Agonist	CXCL6, CXCL8, cytokine domain of tyrosyl tRNA synthetase	peptide	Ishimoto N, Park JH, Kawakami K, Tajiri M, Mizutani K, Akashi S, Tame JRH, Inoue A, Park SY	10.1038/S41467-023-39799-2	2023-07-19	56200
G12/13	α12	Human	Mini-G12	55	β1	Human	γ2	Human	Cryo-EM	7YDJ	-	3.0	AGRE5	ADGRE5	ADGRE	B2 (Adhesion)	Human	-	scFv16	-	Apo (no ligand)	none	Apo (no ligand)	-	-	-	-	2023-07-12	56212
G12/13	α13	Human	Gi2-mini-G13 chimera	57	β1	Human	γ2	Human	Cryo-EM	7YDH	-	3.1	AGRE5	ADGRE5	ADGRE	B2 (Adhesion)	Human	-	scFv16	-	Apo (no ligand)	none	Apo (no ligand)	-	-	Wang N, Qian Y, Xia R, Zhu X, Xiong Y, Zhang A, Guo C, He Y	10.1016/J.CHEMBIOL.2023.08.003	2023-07-12	56213
Gq/11	αq	Human	-	60	β1	Human	γ2	Human	Cryo-EM	8IUM	-	3.1	PF2R	FP	Prostanoid	A (Rhodopsin)	Human	-	scFv16 Nanobody-35	-	tafluprost acid pubchem gtoplig	small-molecule	Agonist	PGF_2α, PGI₂, PGE₂, thromboxane A₂, PGD₂	small-molecule	Wu C, Xu Y, He Q, Li D, Duan J, Li C, You C, Chen H, Fan W, Jiang Y, Eric Xu H	10.1038/S41467-023-38411-X	2023-07-12	56208
Gq/11	αq	Human	-	60	β1	Human	γ2	Human	Cryo-EM	8IUL	-	2.8	PF2R	FP	Prostanoid	A (Rhodopsin)	Human	-	scFv16	-	latanoprost (free acid form) pubchem gtoplig chembl_ligand	small-molecule	Agonist	PGF_2α, PGI₂, PGE₂, thromboxane A₂, PGD₂	small-molecule	Wu C, Xu Y, He Q, Li D, Duan J, Li C, You C, Chen H, Fan W, Jiang Y, Eric Xu H	10.1038/S41467-023-38411-X	2023-07-12	56208
Gq/11	αq	Human	Mini-Gq	60	β1	Human	γ2	Human	Cryo-EM	7YDM	-	2.9	AGRE5	ADGRE5	ADGRE	B2 (Adhesion)	Human	-	Nanobody-35	-	Apo (no ligand)	none	Apo (no ligand)	-	-	Wang N, Qian Y, Xia R, Zhu X, Xiong Y, Zhang A, Guo C, He Y	10.1016/J.CHEMBIOL.2023.08.003	2023-07-12	56208
Gq/11	αq	Human	-	60	β1	Human	γ2	Human	Cryo-EM	8IUK	-	2.7	PF2R	FP	Prostanoid	A (Rhodopsin)	Human	-	scFv16 Nanobody-35	-	PGF_2α pubchem gtoplig chembl_ligand drug_central drugbank	small-molecule	Agonist	PGF_2α, PGI₂, PGE₂, thromboxane A₂, PGD₂	small-molecule	Wu C, Xu Y, He Q, Li D, Duan J, Li C, You C, Chen H, Fan W, Jiang Y, Eric Xu H	10.1038/S41467-023-38411-X	2023-07-12	56208
Gs	αs	Human	Mini-Gs	59	β1	Human	γ2	Human	Cryo-EM	7YDP	-	3.1	AGRE5	ADGRE5	ADGRE	B2 (Adhesion)	Human	-	Nanobody-35	-	Apo (no ligand)	none	Apo (no ligand)	-	-	Wang N, Qian Y, Xia R, Zhu X, Xiong Y, Zhang A, Guo C, He Y	10.1016/J.CHEMBIOL.2023.08.003	2023-07-12	56198
Gq/11	αq	Human	Mini-Gq	51	-	-	-	-	Cryo-EM	7YMH	7YMH_refined	3.5	ADA1A	α_1A	Adrenoceptors	A (Rhodopsin)	Human	-	Nanobody-29	-	Noradrenaline pubchem	small-molecule	Agonist	(-)-adrenaline, (-)-noradrenaline	small-molecule	Toyoda Y, Zhu A, Kong F, Shan S, Zhao J, Wang N, Sun X, Zhang L, Yan C, Kobilka BK, Liu X	10.1038/S41467-023-39310-X	2023-07-05	56208
Gq/11	αq	Human	Mini-Gq	46	-	-	-	-	Cryo-EM	7YM8	7YM8_refined	2.9	ADA1A	α_1A	Adrenoceptors	A (Rhodopsin)	Human	-	Nanobody-29	-	oxymetazoline pubchem gtoplig chembl_ligand drugbank drug_central pubchem	small-molecule	Agonist	(-)-adrenaline, (-)-noradrenaline	small-molecule	Toyoda Y, Zhu A, Kong F, Shan S, Zhao J, Wang N, Sun X, Zhang L, Yan C, Kobilka BK, Liu X	10.1038/S41467-023-39310-X	2023-07-05	56208
Gs	αs	Human	-	57	β1	Rat	γ2	Bovine	Cryo-EM	7Y36	-	2.8	PTH1R	PTH1	Parathyroid hormone	B1 (Secretin)	Human	-	Nanobody-35	-	Parathyroid hormone pubchem	peptide	Agonist	PTH, PTHrP, TIP39, PTHrP-(1-36)	peptide	-	-	2023-07-05	56198
Gs	αs	Human	-	57	β1	Rat	γ2	Bovine	Cryo-EM	7Y35	-	2.9	PTH1R	PTH1	Parathyroid hormone	B1 (Secretin)	Human	-	Nanobody-35	-	abaloparatide pubchem	small-molecule	Agonist	PTH, PTHrP, TIP39, PTHrP-(1-36)	peptide	-	-	2023-07-05	56198
Gs	αs	Human	-	58	β1	Human	γ2	Human	Cryo-EM	8JLZ	-	3.1	5HT6R	5-HT₆	5-Hydroxytryptamine	A (Rhodopsin)	Human	-	Nanobody-35	-	CHEMBL365751 chembl_ligand pubchem	small-molecule	Agonist	5-hydroxytryptamine	small-molecule	Pei Y, Wen X, Guo SC, Yang ZS, Zhang R, Xiao P, Sun JP	10.1016/J.BBRC.2023.05.126	2023-06-28	56198
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	8J1A	-	3.2	GPR84	GPR84	A orphans	A (Rhodopsin)	Human	-	scFv16	-	Apo (no ligand)	none	Apo (no ligand)	-	-	Liu H, Zhang Q, He X, Jiang M, Wang S, Yan X, Cheng X, Liu Y, Nan FJ, Xu HE, Xie X, Yin W	10.1038/S41467-023-38985-6	2023-06-21	56200
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	8J18	-	2.9	GPR84	GPR84	A orphans	A (Rhodopsin)	Human	-	scFv16	-	(3R)-3-HYDROXYDODECANOIC ACID pubchem	small-molecule	Agonist	-	-	Liu H, Zhang Q, He X, Jiang M, Wang S, Yan X, Cheng X, Liu Y, Nan FJ, Xu HE, Xie X, Yin W	10.1038/S41467-023-38985-6	2023-06-21	56200
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	8JD3	-	3.3	GRM2	mGlu₂	Metabotropic glutamate	C (Glutamate)	Human	-	-	-	L-glutamic acid pubchem gtoplig chembl_ligand drugbank drug_central pubchem pubchem JNJ-40411813 pubchem gtoplig chembl_ligand drugbank	small-molecule small-molecule	Agonist PAM	L-glutamic acid	small-molecule	Wang X, Wang M, Xu T, Feng Y, Shao Q, Han S, Chu X, Xu Y, Lin S, Zhao Q, Wu B	10.1038/S41422-023-00830-2	2023-06-21	56200
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	8J19	-	3.2	GPR84	GPR84	A orphans	A (Rhodopsin)	Human	-	scFv16	-	6-nonylpyridine-2,4-diol pubchem gtoplig chembl_ligand	small-molecule	Agonist	-	-	Liu H, Zhang Q, He X, Jiang M, Wang S, Yan X, Cheng X, Liu Y, Nan FJ, Xu HE, Xie X, Yin W	10.1038/S41467-023-38985-6	2023-06-21	56200
Gi/o	αi3	Human	-	63	β1	Human	γ2	Human	Cryo-EM	8JD6	-	3.4	GRM4	mGlu₄	Metabotropic glutamate	C (Glutamate)	Human	-	scFv16	-	VU0364770 pubchem gtoplig chembl_ligand	small-molecule	Agonist	L-serine-O-phosphate, L-glutamic acid	small-molecule	Wang X, Wang M, Xu T, Feng Y, Shao Q, Han S, Chu X, Xu Y, Lin S, Zhao Q, Wu B	10.1038/S41422-023-00830-2	2023-06-21	56202
Gi/o	αi1	Human	-	63	β1	Human	γ2	Human	Cryo-EM	8JD5	-	3.6	GRM2	mGlu₂	Metabotropic glutamate	C (Glutamate)	Human	-	scFv16	-	L-glutamic acid pubchem gtoplig chembl_ligand drugbank drug_central pubchem pubchem ADX88178 pubchem gtoplig chembl_ligand JNJ-40411813 pubchem gtoplig chembl_ligand drugbank	small-molecule small-molecule small-molecule	Agonist	L-glutamic acid	small-molecule	Wang X, Wang M, Xu T, Feng Y, Shao Q, Han S, Chu X, Xu Y, Lin S, Zhao Q, Wu B	10.1038/S41422-023-00830-2	2023-06-21	56200
Gi/o	αi1	Human	-	60	β1	Human	γ2	Human	Cryo-EM	8IRU	-	3.2	DRD4	D₄	Dopamine	A (Rhodopsin)	Human	-	scFv16	-	rotigotine pubchem gtoplig chembl_ligand drugbank drug_central pubchem	small-molecule	Agonist	dopamine	small-molecule	Xu P, Huang S, Krumm BE, Zhuang Y, Mao C, Zhang Y, Wang Y, Huang XP, Liu YF, He X, Li H, Yin W, Jiang Y, Zhang Y, Roth BL, Xu HE	10.1038/S41422-023-00808-0	2023-06-21	56200
Gq/11	αq	Human	-	99	β1	Human	γ2	Human	Cryo-EM	8IYS	-	3.0	FFAR4	FFA4	Free fatty acid	A (Rhodopsin)	Human	-	scFv16	-	TUG-891 pubchem gtoplig chembl_ligand	small-molecule	Agonist	oleic acid, myristic acid, linoleic acid, α-linolenic acid	small-molecule	Yin H, Inoue A, Ma Z, Zhu X, Xia R, Xu Z, Wang N, Duan Y, Zhang A, Guo C, He Y	10.1038/S41422-023-00835-X	2023-06-21	56208
Gq/11	αq	Human	-	60	β1	Human	γ2	Human	Cryo-EM	8H4L	-	3.1	FFAR4	FFA4	Free fatty acid	A (Rhodopsin)	Human	-	Nanobody-35	-	docosahexaenoic acid pubchem gtoplig chembl_ligand drug_central drugbank pubchem	small-molecule	Agonist	oleic acid, myristic acid, linoleic acid, α-linolenic acid	small-molecule	Yin H, Inoue A, Ma Z, Zhu X, Xia R, Xu Z, Wang N, Duan Y, Zhang A, Guo C, He Y	10.1038/S41422-023-00835-X	2023-06-21	56208
Gq/11	αq	Human	Mini-Gq	60	β1	Human	γ2	Human	Cryo-EM	8H4K	-	3.1	FFAR4	FFA4	Free fatty acid	A (Rhodopsin)	Human	-	Nanobody-35	-	GW9508 pubchem gtoplig chembl_ligand	small-molecule	Agonist	oleic acid, myristic acid, linoleic acid, α-linolenic acid	small-molecule	Yin H, Inoue A, Ma Z, Zhu X, Xia R, Xu Z, Wang N, Duan Y, Zhang A, Guo C, He Y	10.1038/S41422-023-00835-X	2023-06-21	56208
Gs	αs	Human	-	61	β1	Human	γ2	Human	Cryo-EM	8HMP	-	2.8	GPR52	GPR52	A orphans	A (Rhodopsin)	Human	-	Nanobody-35	-	derivative 17 [Nakahata et al., 2018] pubchem gtoplig chembl_ligand	small-molecule	Agonist	-	-	Fan Y, Lin X, Pan B, Chen B, Liu D, Wuthrich K, Xu F	10.1002/MCO2.260	2023-06-21	56198
Gs	αs	Human	-	59	β1	Human	γ2	Human	Cryo-EM	8H4I	-	3.1	FFAR4	FFA4	Free fatty acid	A (Rhodopsin)	Human	-	Nanobody-35	-	docosahexaenoic acid pubchem gtoplig chembl_ligand drug_central drugbank pubchem	small-molecule	Agonist	oleic acid, myristic acid, linoleic acid, α-linolenic acid	small-molecule	Yin H, Inoue A, Ma Z, Zhu X, Xia R, Xu Z, Wang N, Duan Y, Zhang A, Guo C, He Y	10.1038/S41422-023-00835-X	2023-06-21	56198
Gs	αs	Human	Mini-Gs	57	β1	Human	γ2	Human	Cryo-EM	8IRR	-	3.2	DRD1	D₁	Dopamine	A (Rhodopsin)	Human	-	Nanobody-35	-	rotigotine pubchem gtoplig chembl_ligand drugbank drug_central pubchem	small-molecule	Agonist	noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, dopamine, 5-hydroxytryptamine	small-molecule	Xu P, Huang S, Krumm BE, Zhuang Y, Mao C, Zhang Y, Wang Y, Huang XP, Liu YF, He X, Li H, Yin W, Jiang Y, Zhang Y, Roth BL, Xu HE	10.1038/S41422-023-00808-0	2023-06-21	56198
Gs	αs	Human	-	58	β1	Rat	γ2	Bovine	Cryo-EM	8GW8	-	2.9	PTH1R	PTH1	Parathyroid hormone	B1 (Secretin)	Human	-	Nanobody-35	-	PCO371 pubchem gtoplig chembl_ligand drugbank	small-molecule	Agonist	PTH, PTHrP, TIP39, PTHrP-(1-36)	peptide	Kobayashi K, Kawakami K, Kusakizako T, Tomita A, Nishimura M, Sawada K, Okamoto HH, Hiratsuka S, Nakamura G, Kuwabara R, Noda H, Muramatsu H, Shimizu M, Taguchi T, Inoue A, Murata T, Nureki O	10.1038/S41586-023-06169-3	2023-06-14	56198
Gi/o	αi2	Human	-	61	β1	Human	γ2	Human	Cryo-EM	7XXI	7XXI_refined	3.0	P2Y12	P2Y₁₂	P2Y	A (Rhodopsin)	Human	-	-	-	2MeSADP pubchem gtoplig chembl_ligand gtoplig	small-molecule	Agonist	ADP, ATP	small-molecule	-	-	2023-06-07	56201
Gi/o	αi1	Human	-	63	β1	Human	γ2	Human	Cryo-EM	8IRS	-	3.0	DRD2	D₂	Dopamine	A (Rhodopsin)	Human	BRIL	scFv16	-	rotigotine pubchem gtoplig chembl_ligand drugbank drug_central pubchem	small-molecule	Agonist	dopamine	small-molecule	Xu P, Huang S, Krumm BE, Zhuang Y, Mao C, Zhang Y, Wang Y, Huang XP, Liu YF, He X, Li H, Yin W, Jiang Y, Zhang Y, Roth BL, Xu HE	10.1038/S41422-023-00808-0	2023-06-07	56200
Gi/o	αi1	Human	-	63	β1	Human	γ2	Human	Cryo-EM	8IRT	-	2.7	DRD3	D₃	Dopamine	A (Rhodopsin)	Human	BRIL	scFv16	-	rotigotine pubchem gtoplig chembl_ligand drugbank drug_central pubchem	small-molecule	Agonist	dopamine	small-molecule	Xu P, Huang S, Krumm BE, Zhuang Y, Mao C, Zhang Y, Wang Y, Huang XP, Liu YF, He X, Li H, Yin W, Jiang Y, Zhang Y, Roth BL, Xu HE	10.1038/S41422-023-00808-0	2023-06-07	56200
Gq/11	α11	Human	-	63	β1	Human	γ2	Human	Cryo-EM	7XXH	7XXH_refined	2.9	P2RY1	P2Y₁	P2Y	A (Rhodopsin)	Human	-	scFv16	-	2MeSADP pubchem gtoplig chembl_ligand gtoplig	small-molecule	Agonist	ADP, ATP	small-molecule	-	-	2023-06-07	56209
Gs	αs	Human	-	60	β1	Human	γ2	Human	Cryo-EM	8IRV	8IRV_refined	3.1	DRD5	D₅	Dopamine	A (Rhodopsin)	Human	BRIL	-	-	rotigotine pubchem gtoplig chembl_ligand drugbank drug_central pubchem	small-molecule	Agonist	noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, dopamine, 5-hydroxytryptamine	small-molecule	Xu P, Huang S, Krumm BE, Zhuang Y, Mao C, Zhang Y, Wang Y, Huang XP, Liu YF, He X, Li H, Yin W, Jiang Y, Zhang Y, Roth BL, Xu HE	10.1038/S41422-023-00808-0	2023-06-07	56198
Gs	αs	Human	-	56	β1	Human	γ2	Human	Cryo-EM	7Y3G	7Y3G_refined	2.8	GPR12	GPR12	A orphans	A (Rhodopsin)	Human	-	Nanobody-35	-	Apo (no ligand)	none	Apo (no ligand)	sphingosine 1-phosphate	small-molecule	Li H, Zhang J, Yu Y, Luo F, Wu L, Liu J, Chen N, Liu Z, Hua T	10.1016/J.SCIB.2022.12.023	2023-06-07	56198
Gq/11	αq	Human	-	59	β1	Rat	γ2	Bovine	Cryo-EM	7XWO	7XWO_refined	2.7	NK2R	NK₂	Tachykinin	A (Rhodopsin)	Human	BRIL	scFv16	-	HIS-LYS-THR-ASP-SER-PHE-VAL-GLY-LEU-MET-NH2	peptide	Agonist	neurokinin A, neuropeptide K, hemokinin 1, neurokinin B, neuropeptide γ, substance P	peptide	-	-	2023-05-31	56208
Gq/11	αq	Human	-	60	β1	Human	γ2	Human	Cryo-EM	8HJ5	8HJ5_refined	3.0	MRGX1	MRGPRX1	A orphans	A (Rhodopsin)	Human	BRIL	scFv16 Nanobody-35	-	compound 16 [PMID: 31498617] pubchem gtoplig chembl_ligand	small-molecule	Agonist	bovine adrenal medulla peptide 8-22	peptide	-	-	2023-05-31	56208
Gs	αs	Human	-	59	β1	Human	γ2	Human	Cryo-EM	8IW7	-	3.0	TAAR9	TAAR9	A orphans	A (Rhodopsin)	Mouse	-	scFv16	-	2-Phenylethanaminium pubchem	small-molecule	Agonist	-	-	Guo L, Cheng J, Lian S, Liu Q, Lu Y, Zheng Y, Zhu K, Zhang M, Kong Y, Zhang C, Rong N, Zhuang Y, Fang G, Jiang J, Zhang T, Han X, Liu Z, Xia M, Liu S, Zhang L, Liberles SD, Yu X, Xu Y, Yang F, Li Q, Sun JP	10.1038/S41586-023-06106-4	2023-05-31	56198
Gs	αs	Human	-	45	β1	Human	γ2	Human	Cryo-EM	8IW4	-	3.5	TAAR9	TAAR9	A orphans	A (Rhodopsin)	Mouse	-	scFv16	-	SPERMIDINE chembl_ligand pubchem	small-molecule	Agonist	-	-	Guo L, Cheng J, Lian S, Liu Q, Lu Y, Zheng Y, Zhu K, Zhang M, Kong Y, Zhang C, Rong N, Zhuang Y, Fang G, Jiang J, Zhang T, Han X, Liu Z, Xia M, Liu S, Zhang L, Liberles SD, Yu X, Xu Y, Yang F, Li Q, Sun JP	10.1038/S41586-023-06106-4	2023-05-31	56198
Gs	αolf	Human	Golf-Gi chimera	59	β1	Human	γ2	Human	Cryo-EM	8IW1	-	3.4	TAAR9	TAAR9	A orphans	A (Rhodopsin)	Mouse	-	scFv16	-	2-Phenylethanaminium pubchem	small-molecule	Agonist	-	-	Guo L, Cheng J, Lian S, Liu Q, Lu Y, Zheng Y, Zhu K, Zhang M, Kong Y, Zhang C, Rong N, Zhuang Y, Fang G, Jiang J, Zhang T, Han X, Liu Z, Xia M, Liu S, Zhang L, Liberles SD, Yu X, Xu Y, Yang F, Li Q, Sun JP	10.1038/S41586-023-06106-4	2023-05-31	56199
Gs	αs	Human	Mini-Gs	59	β1	Human	γ2	Human	Cryo-EM	8IW9	-	3.1	TAAR9	TAAR9	A orphans	A (Rhodopsin)	Mouse	-	scFv16 Nanobody-35	-	Cadaverine pubchem	small-molecule	Agonist	-	-	Guo L, Cheng J, Lian S, Liu Q, Lu Y, Zheng Y, Zhu K, Zhang M, Kong Y, Zhang C, Rong N, Zhuang Y, Fang G, Jiang J, Zhang T, Han X, Liu Z, Xia M, Liu S, Zhang L, Liberles SD, Yu X, Xu Y, Yang F, Li Q, Sun JP	10.1038/S41586-023-06106-4	2023-05-31	56198
Gs	αs	Human	-	59	β1	Human	γ2	Human	Cryo-EM	8ITF	-	3.5	TAAR9	TAAR9	A orphans	A (Rhodopsin)	Mouse	-	scFv16 Nanobody-35	-	N,N-Dimethylcyclohexylamine pubchem	small-molecule	Agonist	-	-	Guo L, Cheng J, Lian S, Liu Q, Lu Y, Zheng Y, Zhu K, Zhang M, Kong Y, Zhang C, Rong N, Zhuang Y, Fang G, Jiang J, Zhang T, Han X, Liu Z, Xia M, Liu S, Zhang L, Liberles SD, Yu X, Xu Y, Yang F, Li Q, Sun JP	10.1038/S41586-023-06106-4	2023-05-31	56198
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	8GHV	8GHV_refined	2.8	CNR1	CB₁	Cannabinoid	A (Rhodopsin)	Human	-	scFv16	-	CHEMBL4208628 chembl_ligand pubchem	small-molecule	Agonist	2-arachidonoylglycerol, anandamide	small-molecule	Krishna Kumar K, Robertson MJ, Thadhani E, Wang H, Suomivuori CM, Powers AS, Ji L, Nikas SP, Dror RO, Inoue A, Makriyannis A, Skiniotis G, Kobilka B	10.1038/S41467-023-37864-4	2023-05-24	56200
Gi/o	αi1	Human	-	61	β1	Human	γ2	Human	Cryo-EM	8IA8	-	2.9	C3AR	C3a	Complement peptide	A (Rhodopsin)	Human	-	scFv16	-	ALA-SER-LYS-LEU-GLY-LEU-ALA-ARG	peptide	Agonist	C5a, C3a	peptide	-	-	2023-05-24	56200
Gi/o	αi1	Human	-	61	β1	Human	γ2	Human	Cryo-EM	7Y1F	7Y1F_refined	3.3	OPRK	κ	Opioid	A (Rhodopsin)	Human	-	scFv16	-	dynorphin A-(1-8) pubchem gtoplig chembl_ligand pubchem pubchem	peptide	Agonist	dynorphin B, dynorphin A-(1-13), dynorphin A-(1-8), β-endorphin, β-neoendorphin, α-neoendorphin, [Met]enkephalin, dynorphin A, [Leu]enkephalin, big dynorphin	peptide	Chen Y, Chen B, Wu T, Zhou F, Xu F	10.1093/PROCEL/PWAC033	2023-05-24	56200
Gi/o	αi3	Human	-	100	-	-	-	-	Cryo-EM	8GVX	-	3.9	-	-	-	-	-	-	-	Short transient receptor potential channel 5	-	-	-	-	-	Won J, Kim J, Jeong H, Kim J, Feng S, Jeong B, Kwak M, Ko J, Im W, So I, Lee HH	37137991	2023-05-24	56202
Gq/11	αq	Human	-	60	β1	Human	γ2	Human	Cryo-EM	8EJC	-	3.0	FFAR1	FFA1	Free fatty acid	A (Rhodopsin)	Human	-	scFv16	-	fasiglifam pubchem gtoplig chembl_ligand drugbank	small-molecule	Agonist	myristic acid, oleic acid, docosahexaenoic acid, α-linolenic acid	small-molecule	Kumari P, Inoue A, Chapman K, Lian P, Rosenbaum DM	10.1073/PNAS.2219569120	2023-05-24	56208
Gq/11	αq	Human	-	60	β1	Human	γ2	Human	Cryo-EM	8EJK	-	3.4	FFAR1	FFA1	Free fatty acid	A (Rhodopsin)	Human	-	scFv16	-	fasiglifam pubchem gtoplig chembl_ligand drugbank	small-molecule	Agonist	myristic acid, oleic acid, docosahexaenoic acid, α-linolenic acid	small-molecule	Kumari P, Inoue A, Chapman K, Lian P, Rosenbaum DM	10.1073/PNAS.2219569120	2023-05-24	56208
Gq/11	αq	Human	-	59	β1	Human	γ2	Human	Cryo-EM	8EIT	-	2.8	FFAR1	FFA1	Free fatty acid	A (Rhodopsin)	Human	-	scFv16	-	docosahexaenoic acid pubchem gtoplig chembl_ligand drug_central drugbank pubchem	small-molecule	Agonist	myristic acid, oleic acid, docosahexaenoic acid, α-linolenic acid	small-molecule	Kumari P, Inoue A, Chapman K, Lian P, Rosenbaum DM	10.1073/PNAS.2219569120	2023-05-24	56208
Gi/o	αi1	Human	-	64	β1	Human	γ2	Human	Cryo-EM	7TRK	-	2.8	ACM4	M₄	Acetylcholine (muscarinic)	A (Rhodopsin)	Human	-	scFv16	-	iperoxo pubchem gtoplig chembl_ligand	small-molecule	Agonist	acetylcholine	small-molecule	-	-	2023-05-17	56200
Gi/o	αi1	Human	-	64	β1	Human	γ2	Human	Cryo-EM	7TRQ	-	2.5	ACM4	M₄	Acetylcholine (muscarinic)	A (Rhodopsin)	Human	-	scFv16	-	iperoxo pubchem gtoplig chembl_ligand VU0467154 pubchem gtoplig chembl_ligand	small-molecule small-molecule	Agonist PAM	acetylcholine	small-molecule	-	-	2023-05-17	56200
Gi/o	αi1	Human	-	64	β1	Human	γ2	Human	Cryo-EM	7TRP	-	2.4	ACM4	M₄	Acetylcholine (muscarinic)	A (Rhodopsin)	Human	-	scFv16	-	iperoxo pubchem gtoplig chembl_ligand LY2033298 pubchem gtoplig chembl_ligand	small-molecule small-molecule	Agonist PAM	acetylcholine	small-molecule	-	-	2023-05-17	56200
Gi/o	αi1	Human	-	63	β1	Human	γ2	Human	Cryo-EM	7TRS	-	2.8	ACM4	M₄	Acetylcholine (muscarinic)	A (Rhodopsin)	Human	-	scFv16	-	acetylcholine pubchem gtoplig chembl_ligand drugbank drug_central gtoplig pubchem	small-molecule	Agonist	acetylcholine	small-molecule	-	-	2023-05-17	56200
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	8GUS	-	3.0	CNR2	CB₂	Cannabinoid	A (Rhodopsin)	Human	-	scFv16	-	CHEMBL2179724 chembl_ligand pubchem	small-molecule	Agonist	2-arachidonoylglycerol, anandamide	small-molecule	Li X, Chang H, Bouma J, de Paus LV, Mukhopadhyay P, Paloczi J, Mustafa M, van der Horst C, Kumar SS, Wu L, Yu Y, van den Berg RJBHN, Janssen APA, Lichtman A, Liu ZJ, Pacher P, van der Stelt M, Heitman LH, Hua T	10.1038/S41467-023-37112-9	2023-05-10	56200
Gi/o	αi1	Human	-	64	β1	Rat	γ2	Bovine	Cryo-EM	8HK2	-	2.9	C3AR	C3a	Complement peptide	A (Rhodopsin)	Human	-	scFv16	-	C3a anaphylatoxin pubchem	peptide	Agonist	C5a, C3a	peptide	Wang Y, Liu W, Xu Y, He X, Yuan Q, Luo P, Fan W, Zhu J, Zhang X, Cheng X, Jiang Y, Xu HE, Zhuang Y	10.1038/S41589-023-01339-W	2023-05-10	56200
Gi/o	αi1	Human	-	63	β1	Rat	γ2	Bovine	Cryo-EM	8HK3	8HK3_refined	3.2	C3AR	C3a	Complement peptide	A (Rhodopsin)	Human	-	scFv16	-	Apo (no ligand)	none	Apo (no ligand)	C5a, C3a	peptide	Wang Y, Liu W, Xu Y, He X, Yuan Q, Luo P, Fan W, Zhu J, Zhang X, Cheng X, Jiang Y, Xu HE, Zhuang Y	10.1038/S41589-023-01339-W	2023-05-10	56200
Gi/o	αi1	Human	-	64	β1	Human	γ2	Human	Cryo-EM	8GUR	8GUR_refined	2.8	CNR2	CB₂	Cannabinoid	A (Rhodopsin)	Human	-	scFv16	-	CP55940 pubchem gtoplig chembl_ligand gtoplig	small-molecule	Agonist	2-arachidonoylglycerol, anandamide	small-molecule	Li X, Chang H, Bouma J, de Paus LV, Mukhopadhyay P, Paloczi J, Mustafa M, van der Horst C, Kumar SS, Wu L, Yu Y, van den Berg RJBHN, Janssen APA, Lichtman A, Liu ZJ, Pacher P, van der Stelt M, Heitman LH, Hua T	10.1038/S41467-023-37112-9	2023-05-10	56200
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	8GUQ	8GUQ_refined	3.1	CNR2	CB₂	Cannabinoid	A (Rhodopsin)	Human	-	scFv16	-	olorinab pubchem gtoplig chembl_ligand drugbank	small-molecule	Agonist	2-arachidonoylglycerol, anandamide	small-molecule	Li X, Chang H, Bouma J, de Paus LV, Mukhopadhyay P, Paloczi J, Mustafa M, van der Horst C, Kumar SS, Wu L, Yu Y, van den Berg RJBHN, Janssen APA, Lichtman A, Liu ZJ, Pacher P, van der Stelt M, Heitman LH, Hua T	10.1038/S41467-023-37112-9	2023-05-10	56200
Gi/o	αi1	Human	-	63	β1	Rat	γ2	Bovine	Cryo-EM	8HK5	8HK5_refined	3.0	C5AR1	C5a₁	Complement peptide	A (Rhodopsin)	Human	-	-	-	C5a gtoplig	peptide	Agonist	C5a, ribosomal protein S19, C5a des-Arg, C3a	peptide	Wang Y, Liu W, Xu Y, He X, Yuan Q, Luo P, Fan W, Zhu J, Zhang X, Cheng X, Jiang Y, Xu HE, Zhuang Y	10.1038/S41589-023-01339-W	2023-05-10	56200
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	8GUT	8GUT_refined	3.0	CNR2	CB₂	Cannabinoid	A (Rhodopsin)	Human	-	scFv16	-	1-[[4-[5-Fluoro-6-[(oxan-4-ylamino)methyl]pyridin-2-yl]phenyl]methyl]-3-(2-methylpropyl)imidazolidine-2,4-dione pubchem	small-molecule	Agonist	2-arachidonoylglycerol, anandamide	small-molecule	Li X, Chang H, Bouma J, de Paus LV, Mukhopadhyay P, Paloczi J, Mustafa M, van der Horst C, Kumar SS, Wu L, Yu Y, van den Berg RJBHN, Janssen APA, Lichtman A, Liu ZJ, Pacher P, van der Stelt M, Heitman LH, Hua T	10.1038/S41467-023-37112-9	2023-05-10	56200
Gq/11	αq	Human	Gs-mini-Gq chimera	52	β1	Human	γ2	Human	Cryo-EM	8G2Y	-	3.4	AGRF1	ADGRF1	ADGRF	B2 (Adhesion)	Human	-	Nanobody-35	-	[1-Myristoyl-glycerol-3-YL]phosphonylcholine pubchem	small-molecule	Agonist	-	-	Jones DTD, Dates AN, Rawson SD, Burruss MM, Lipper CH, Blacklow SC	10.1038/S41467-023-38083-7	2023-05-10	56208
Gi/o	αgust	Human	-	58	β1	Human	γ2	Human	Cryo-EM	8DZR	-	2.6	OPRK	κ	Opioid	A (Rhodopsin)	Human	-	scFv16	-	CHEMBL277863 chembl_ligand pubchem	small-molecule	Agonist	dynorphin B, dynorphin A-(1-13), dynorphin A-(1-8), β-endorphin, β-neoendorphin, α-neoendorphin, [Met]enkephalin, dynorphin A, [Leu]enkephalin, big dynorphin	peptide	Han J, Zhang J, Nazarova AL, Bernhard SM, Krumm BE, Zhao L, Lam JH, Rangari VA, Majumdar S, Nichols DE, Katritch V, Yuan P, Fay JF, Che T	10.1038/S41586-023-06030-7	2023-05-03	56205
Gi/o	αo	Human	-	61	β1	Human	γ2	Human	Cryo-EM	8DZQ	8DZQ_refined	2.8	OPRK	κ	Opioid	A (Rhodopsin)	Human	-	scFv16	-	SALVINORIN B METHOXYMETHYL ETHER chembl_ligand pubchem	small-molecule	Agonist	dynorphin B, dynorphin A-(1-13), dynorphin A-(1-8), β-endorphin, β-neoendorphin, α-neoendorphin, [Met]enkephalin, dynorphin A, [Leu]enkephalin, big dynorphin	peptide	Han J, Zhang J, Nazarova AL, Bernhard SM, Krumm BE, Zhao L, Lam JH, Rangari VA, Majumdar S, Nichols DE, Katritch V, Yuan P, Fay JF, Che T	10.1038/S41586-023-06030-7	2023-05-03	56206
Gi/o	αi1	Human	-	60	β1	Human	γ2	Human	Cryo-EM	8DZP	-	2.7	OPRK	κ	Opioid	A (Rhodopsin)	Human	-	scFv16	-	SALVINORIN B METHOXYMETHYL ETHER chembl_ligand pubchem	small-molecule	Agonist	dynorphin B, dynorphin A-(1-13), dynorphin A-(1-8), β-endorphin, β-neoendorphin, α-neoendorphin, [Met]enkephalin, dynorphin A, [Leu]enkephalin, big dynorphin	peptide	Han J, Zhang J, Nazarova AL, Bernhard SM, Krumm BE, Zhao L, Lam JH, Rangari VA, Majumdar S, Nichols DE, Katritch V, Yuan P, Fay JF, Che T	10.1038/S41586-023-06030-7	2023-05-03	56200
Gi/o	αo	Human	-	61	β1	Human	γ2	Human	Cryo-EM	7XJJ	7XJJ_refined	3.3	GALR1	GAL₁	Galanin	A (Rhodopsin)	Human	-	scFv16	-	galanin pubchem gtoplig chembl_ligand gtoplig pubchem pubchem pubchem pubchem	peptide	Agonist	galanin, galanin-like peptide	peptide	-	-	2023-05-03	56206
Gi/o	αz	Human	-	59	β1	Human	γ2	Human	Cryo-EM	8DZS	-	2.7	OPRK	κ	Opioid	A (Rhodopsin)	Human	-	scFv16	-	CHEMBL277863 chembl_ligand pubchem	small-molecule	Agonist	dynorphin B, dynorphin A-(1-13), dynorphin A-(1-8), β-endorphin, β-neoendorphin, α-neoendorphin, [Met]enkephalin, dynorphin A, [Leu]enkephalin, big dynorphin	peptide	Han J, Zhang J, Nazarova AL, Bernhard SM, Krumm BE, Zhao L, Lam JH, Rangari VA, Majumdar S, Nichols DE, Katritch V, Yuan P, Fay JF, Che T	10.1038/S41586-023-06030-7	2023-05-03	56207
Gs	αs	Human	Mini-Gs	57	β1	Human	γ2	Human	Cryo-EM	7XY7	-	3.3	AA2BR	A_2B	Adenosine	A (Rhodopsin)	Human	BRIL	-	-	NECA pubchem gtoplig chembl_ligand gtoplig	small-molecule	Agonist	adenosine	small-molecule	Chen Y, Zhang J, Weng Y, Xu Y, Lu W, Liu W, Liu M, Hua T, Song G	10.1126/SCIADV.ADD3709	2023-05-03	56198
Gs	αs	Human	-	57	β1	Human	γ2	Human	Cryo-EM	7XY6	-	3.0	AA2BR	A_2B	Adenosine	A (Rhodopsin)	Human	BRIL	-	-	BAY 60-6583 pubchem gtoplig chembl_ligand	small-molecule	Agonist	adenosine	small-molecule	Chen Y, Zhang J, Weng Y, Xu Y, Lu W, Liu W, Liu M, Hua T, Song G	10.1126/SCIADV.ADD3709	2023-05-03	56198
Gi/o	αi3	Human	-	100	-	-	-	-	Cryo-EM	7X6I	-	3.9	-	-	-	-	-	-	-	Short transient receptor potential channel 5	-	-	-	-	-	Won J, Kim J, Jeong H, Kim J, Feng S, Jeong B, Kwak M, Ko J, Im W, So I, Lee HH	37137991	2023-04-26	56202
Gs	αs	Human	-	59	β1	Human	γ2	Human	Cryo-EM	8FLQ	-	2.6	PTH1R	PTH1	Parathyroid hormone	B1 (Secretin)	Human	-	Nanobody-35	-	Parathyroid hormone	peptide	Agonist	PTH, PTHrP, TIP39, PTHrP-(1-36)	peptide	Cary BP, Gerrard EJ, Belousoff MJ, Fletcher MM, Jiang Y, Russell IC, Piper SJ, Wootten D, Sexton PM	10.1016/J.STR.2023.04.002	2023-04-26	56198
Gs	αs	Human	-	59	β1	Human	γ2	Human	Cryo-EM	8FLT	-	3.0	PTH1R	PTH1	Parathyroid hormone	B1 (Secretin)	Human	-	Nanobody-35	-	M-PTH(1-14)	peptide	Agonist	PTH, PTHrP, TIP39, PTHrP-(1-36)	peptide	Cary BP, Gerrard EJ, Belousoff MJ, Fletcher MM, Jiang Y, Russell IC, Piper SJ, Wootten D, Sexton PM	10.1016/J.STR.2023.04.002	2023-04-26	56198
Gs	αs	Human	-	58	β1	Human	γ2	Human	Cryo-EM	8FLU	-	2.8	PTH1R	PTH1	Parathyroid hormone	B1 (Secretin)	Human	-	Nanobody-35	-	PTH	peptide	Agonist	PTH, PTHrP, TIP39, PTHrP-(1-36)	peptide	Cary BP, Gerrard EJ, Belousoff MJ, Fletcher MM, Jiang Y, Russell IC, Piper SJ, Wootten D, Sexton PM	10.1016/J.STR.2023.04.002	2023-04-26	56198
Gs	αs	Human	-	59	β1	Human	γ2	Human	Cryo-EM	8FLR	-	2.9	PTH1R	PTH1	Parathyroid hormone	B1 (Secretin)	Human	-	Nanobody-35	-	PTHrP[1-36]	peptide	Agonist	PTH, PTHrP, TIP39, PTHrP-(1-36)	peptide	Cary BP, Gerrard EJ, Belousoff MJ, Fletcher MM, Jiang Y, Russell IC, Piper SJ, Wootten D, Sexton PM	10.1016/J.STR.2023.04.002	2023-04-26	56198
Gs	αs	Human	-	59	β1	Human	γ2	Human	Cryo-EM	8FLS	-	3.1	PTH1R	PTH1	Parathyroid hormone	B1 (Secretin)	Human	-	Nanobody-35	-	abaloparatide pubchem	small-molecule	Agonist	PTH, PTHrP, TIP39, PTHrP-(1-36)	peptide	Cary BP, Gerrard EJ, Belousoff MJ, Fletcher MM, Jiang Y, Russell IC, Piper SJ, Wootten D, Sexton PM	10.1016/J.STR.2023.04.002	2023-04-26	56198
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	8G94	8G94_refined	3.2	S1PR1	S1P₁	Lysophospholipid (S1P)	A (Rhodopsin)	Human	-	scFv16	-	Early activation antigen CD69 pubchem	peptide	Agonist	dihydrosphingosine 1-phosphate, sphingosylphosphorylcholine, sphingosine 1-phosphate	small-molecule	Chen H, Qin Y, Chou M, Cyster JG, Li X	10.7554/ELIFE.88204	2023-04-19	56200
Gi/o	αi1	Human	-	61	β1	Human	γ2	Human	Cryo-EM	7YKD	-	2.8	CML1	chemerin	Chemerin receptor	A (Rhodopsin)	Human	-	scFv16	-	chemerin C-terminal peptide pubchem gtoplig chembl_ligand pubchem	peptide	Agonist	18R-HEPE, resolvin E1, chemerin C-terminal peptide, chemerin, EPA	peptide	Wang J, Chen G, Liao Q, Lyu W, Liu A, Zhu L, Du Y, Ye RD	10.1073/PNAS.2214324120	2023-04-19	56200
Gi/o	αi1	Human	-	64	β1	Human	γ2	Human	Cryo-EM	7YAE	7YAE_refined	3.4	SSR2	SST2	Somatostatin	A (Rhodopsin)	Human	-	scFv16	-	Octreotide	peptide	Agonist	CST-17, SRIF-14, cortistatin-14, SRIF-28	peptide	Zhao J, Fu H, Yu J, Hong W, Tian X, Qi J, Sun S, Zhao C, Wu C, Xu Z, Cheng L, Chai R, Yan W, Wei X, Shao Z	10.1038/S41467-023-36673-Z	2023-04-19	56200
Gi/o	αi1	Human	-	64	β1	Human	γ2	Human	Cryo-EM	7YAC	7YAC_refined	3.2	SSR2	SST2	Somatostatin	A (Rhodopsin)	Human	-	scFv16	-	PALTUSOTINE chembl_ligand pubchem chembl_ligand pubchem	small-molecule	Agonist	CST-17, SRIF-14, cortistatin-14, SRIF-28	peptide	Zhao J, Fu H, Yu J, Hong W, Tian X, Qi J, Sun S, Zhao C, Wu C, Xu Z, Cheng L, Chai R, Yan W, Wei X, Shao Z	10.1038/S41467-023-36673-Z	2023-04-19	56200
Gq/11	αq	Human	-	60	β1	Human	γ2	Human	Cryo-EM	8IBU	8IBU_refined	3.5	MTLR	motilin	Motilin	A (Rhodopsin)	Human	BRIL	scFv16	-	erythromycin pubchem gtoplig chembl_ligand drugbank drug_central	small-molecule	Agonist	motilin	peptide	You C, Zhang Y, Xu Y, Xu P, Li Z, Li H, Huang S, Chen Z, Li J, Xu HE, Jiang Y	10.1126/SCIADV.ADE9020	2023-04-12	56208
Gq/11	αq	Human	-	60	β1	Human	γ2	Human	Cryo-EM	8IBV	8IBV_refined	3.2	MTLR	motilin	Motilin	A (Rhodopsin)	Human	BRIL	scFv16	-	motilin pubchem gtoplig chembl_ligand gtoplig pubchem pubchem	peptide	Agonist	motilin	peptide	You C, Zhang Y, Xu Y, Xu P, Li Z, Li H, Huang S, Chen Z, Li J, Xu HE, Jiang Y	10.1126/SCIADV.ADE9020	2023-04-12	56208
Gs	αs	Human	-	54	β1	Human	γ2	Human	Cryo-EM	8FU6	8FU6_refined	2.9	GLR	glucagon	Glucagon	B1 (Secretin)	Human	-	Nanobody-35	-	Glucagon derivative ZP3780	peptide	Agonist	glucagon	peptide	Krishna Kumar K, O'Brien ES, Habrian CH, Latorraca NR, Wang H, Tuneew I, Montabana E, Marqusee S, Hilger D, Isacoff EY, Mathiesen JM, Kobilka BK	10.1016/J.CELL.2023.02.028	2023-04-12	56198
Gi/o	αo	Human	Mini-Go	60	β1	Human	γ2	Human	Cryo-EM	8FN0	-	2.9	NTR1	NTS₁	Neurotensin	A (Rhodopsin)	Rat	-	scFv16	-	neurotensin pubchem gtoplig chembl_ligand gtoplig gtoplig CHEMBL4576388 chembl_ligand pubchem	peptide small-molecule	Agonist PAM	neurotensin, neuromedin N	peptide	Krumm BE, DiBerto JF, Olsen RHJ, Kang HJ, Slocum ST, Zhang S, Strachan RT, Huang XP, Slosky LM, Pinkerton AB, Barak LS, Caron MG, Kenakin T, Fay JF, Roth BL	10.1021/ACS.BIOCHEM.3C00029	2023-03-29	56206
Gi/o	αo	Human	-	60	β1	Human	γ2	Human	Cryo-EM	8FN1	-	2.9	NTR1	NTS₁	Neurotensin	A (Rhodopsin)	Rat	-	scFv16	-	neurotensin pubchem gtoplig chembl_ligand gtoplig gtoplig	peptide	Agonist	neurotensin, neuromedin N	peptide	Krumm BE, DiBerto JF, Olsen RHJ, Kang HJ, Slocum ST, Zhang S, Strachan RT, Huang XP, Slosky LM, Pinkerton AB, Barak LS, Caron MG, Kenakin T, Fay JF, Roth BL	10.1021/ACS.BIOCHEM.3C00029	2023-03-29	56206
Gq/11	αq	Human	-	97	β1	Human	γ2	Human	Cryo-EM	7F6G	7F6G_refined	2.9	AGTR1	AT₁	Angiotensin	A (Rhodopsin)	Human	-	-	-	SAR1-AngII	peptide	Agonist	angiotensin III, angiotensin IV, angiotensin A, angiotensin II	peptide	-	-	2023-03-29	56208
Gq/11	αq	Human	Mini-Gq	57	β1	Human	γ2	Human	Cryo-EM	8FMZ	-	2.6	NTR1	NTS₁	Neurotensin	A (Rhodopsin)	Rat	-	scFv16	-	neurotensin pubchem gtoplig chembl_ligand gtoplig gtoplig	peptide	Agonist	neurotensin, neuromedin N	peptide	Krumm BE, DiBerto JF, Olsen RHJ, Kang HJ, Slocum ST, Zhang S, Strachan RT, Huang XP, Slosky LM, Pinkerton AB, Barak LS, Caron MG, Kenakin T, Fay JF, Roth BL	10.1021/ACS.BIOCHEM.3C00029	2023-03-29	56208
Gs	αs	Human	fused Gs	58	β1	Human	γ2	Human	Cryo-EM	8I2G	-	2.8	FSHR	FSH	Glycoprotein hormone	A (Rhodopsin)	Human	-	Nanobody-35	-	Follitropin subunit beta Glycoprotein alpha FSHR agonist 1 pubchem	peptide peptide small-molecule	Agonist	FSH	peptide	Duan J, Xu P, Zhang H, Luan X, Yang J, He X, Mao C, Shen DD, Ji Y, Cheng X, Jiang H, Jiang Y, Zhang S, Zhang Y, Xu HE	10.1038/S41467-023-36170-3	2023-03-29	56198
Gs	αs	Human	-	59	β1	Human	γ2	Human	Cryo-EM	7YS6	7YS6_refined	3.0	5HT6R	5-HT₆	5-Hydroxytryptamine	A (Rhodopsin)	Human	-	scFv16	-	5-hydroxytryptamine pubchem gtoplig chembl_ligand drugbank	small-molecule	Agonist	5-hydroxytryptamine	small-molecule	-	-	2023-03-29	56198
Gi/o	αi1	Human	-	61	β1	Human	γ2	Human	Cryo-EM	8HBD	8HBD_refined	3.0	EDNRB	ET_B	Endothelin	A (Rhodopsin)	Human	-	scFv16	-	sovateltide pubchem gtoplig chembl_ligand gtoplig pubchem pubchem pubchem drugbank	peptide	Agonist	endothelin-2, endothelin-3, endothelin-1	peptide	-	-	2023-03-22	56200
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	7YON	7YON_refined	3.0	NPY2R	Y₂	Neuropeptide Y	A (Rhodopsin)	Human	-	scFv16	-	Peptide YY	peptide	Agonist	PYY-(3-36), peptide YY, neuropeptide Y-(3-36), pancreatic polypeptide, neuropeptide Y	peptide	Kang H, Park C, Choi YK, Bae J, Kwon S, Kim J, Choi C, Seok C, Im W, Choi HJ	10.1016/J.STR.2022.11.010	2023-03-22	56200
Gi/o	αi1	Human	-	100	β1	Human	γ2	Human	Cryo-EM	7YOO	-	3.1	-	-	-	-	-	-	single-chain antibody Fv fragment (scFv16)	Neuropeptide Y Neuropeptide Y receptor type 2	-	-	-	-	-	Kang H, Park C, Choi YK, Bae J, Kwon S, Kim J, Choi C, Seok C, Im W, Choi HJ	36525977	2023-03-22	56200
Gq/11	αq	Human	-	57	β1	Human	γ2	Human	Cryo-EM	8HCQ	8HCQ_refined	3.0	EDNRA	ET_A	Endothelin	A (Rhodopsin)	Human	-	scFv16	-	ENDOTHELIN chembl_ligand pubchem	protein	Agonist	endothelin-2, endothelin-3, endothelin-1	peptide	-	-	2023-03-22	56208
Gq/11	αq	Human	-	61	β1	Human	γ2	Human	Cryo-EM	8HCX	8HCX_refined	3.5	EDNRB	ET_B	Endothelin	A (Rhodopsin)	Human	-	scFv16	-	ENDOTHELIN chembl_ligand pubchem	protein	Agonist	endothelin-2, endothelin-3, endothelin-1	peptide	-	-	2023-03-22	56208
Gs	αs	Human	Mini-Gs	55	β1	Human	γ2	Human	Cryo-EM	8F76	8F76_refined	3.1	O51E2	OR51E2	Odorant family 51	O1 (fish-like odorant)	Human	-	Nanobody-35	-	propanoic acid pubchem gtoplig chembl_ligand drugbank	small-molecule	Agonist	-	-	Billesbolle CB, de March CA, van der Velden WJC, Ma N, Tewari J, Del Torrent CL, Li L, Faust B, Vaidehi N, Matsunami H, Manglik A	10.1038/S41586-023-05798-Y	2023-03-22	56198
Gi/o	αi1	Human	-	64	β1	Human	γ2	Human	Cryo-EM	8ID8	-	3.0	FFAR4	FFA4	Free fatty acid	A (Rhodopsin)	Human	-	scFv16	-	TUG-891 pubchem gtoplig chembl_ligand	small-molecule	Agonist	oleic acid, myristic acid, linoleic acid, α-linolenic acid	small-molecule	Mao C, Xiao P, Tao XN, Qin J, He QT, Zhang C, Guo SC, Du YQ, Chen LN, Shen DD, Yang ZS, Zhang HQ, Huang SM, He YH, Cheng J, Zhong YN, Shang P, Chen J, Zhang DL, Wang QL, Liu MX, Li GY, Guo Y, Xu HE, Wang C, Zhang C, Feng S, Yu X, Zhang Y, Sun JP	10.1126/SCIENCE.ADD6220	2023-03-15	56200
Gi/o	αi1	Human	-	56	β1	Human	γ2	Human	Cryo-EM	8ID9	8ID9_refined	3.0	FFAR4	FFA4	Free fatty acid	A (Rhodopsin)	Human	-	scFv16	-	EPA pubchem gtoplig chembl_ligand drugbank drug_central	small-molecule	Agonist	oleic acid, myristic acid, linoleic acid, α-linolenic acid	small-molecule	Mao C, Xiao P, Tao XN, Qin J, He QT, Zhang C, Guo SC, Du YQ, Chen LN, Shen DD, Yang ZS, Zhang HQ, Huang SM, He YH, Cheng J, Zhong YN, Shang P, Chen J, Zhang DL, Wang QL, Liu MX, Li GY, Guo Y, Xu HE, Wang C, Zhang C, Feng S, Yu X, Zhang Y, Sun JP	10.1126/SCIENCE.ADD6220	2023-03-15	56200
Gi/o	αi1	Human	-	64	β1	Human	γ2	Human	Cryo-EM	8ID3	8ID3_refined	3.1	FFAR4	FFA4	Free fatty acid	A (Rhodopsin)	Human	-	scFv16	-	9-Hydroxyoctadecanoic acid pubchem	small-molecule	Agonist	oleic acid, myristic acid, linoleic acid, α-linolenic acid	small-molecule	Mao C, Xiao P, Tao XN, Qin J, He QT, Zhang C, Guo SC, Du YQ, Chen LN, Shen DD, Yang ZS, Zhang HQ, Huang SM, He YH, Cheng J, Zhong YN, Shang P, Chen J, Zhang DL, Wang QL, Liu MX, Li GY, Guo Y, Xu HE, Wang C, Zhang C, Feng S, Yu X, Zhang Y, Sun JP	10.1126/SCIENCE.ADD6220	2023-03-15	56200
Gi/o	αi1	Human	-	64	β1	Human	γ2	Human	Cryo-EM	8ID4	-	3.1	FFAR4	FFA4	Free fatty acid	A (Rhodopsin)	Human	-	scFv16	-	linoleic acid pubchem gtoplig chembl_ligand drug_central drugbank	small-molecule	Agonist	oleic acid, myristic acid, linoleic acid, α-linolenic acid	small-molecule	Mao C, Xiao P, Tao XN, Qin J, He QT, Zhang C, Guo SC, Du YQ, Chen LN, Shen DD, Yang ZS, Zhang HQ, Huang SM, He YH, Cheng J, Zhong YN, Shang P, Chen J, Zhang DL, Wang QL, Liu MX, Li GY, Guo Y, Xu HE, Wang C, Zhang C, Feng S, Yu X, Zhang Y, Sun JP	10.1126/SCIENCE.ADD6220	2023-03-15	56200
Gi/o	αi1	Human	-	64	β1	Human	γ2	Human	Cryo-EM	8ID6	-	2.8	FFAR4	FFA4	Free fatty acid	A (Rhodopsin)	Human	-	scFv16	-	oleic acid pubchem gtoplig chembl_ligand drug_central	small-molecule	Agonist	oleic acid, myristic acid, linoleic acid, α-linolenic acid	small-molecule	Mao C, Xiao P, Tao XN, Qin J, He QT, Zhang C, Guo SC, Du YQ, Chen LN, Shen DD, Yang ZS, Zhang HQ, Huang SM, He YH, Cheng J, Zhong YN, Shang P, Chen J, Zhang DL, Wang QL, Liu MX, Li GY, Guo Y, Xu HE, Wang C, Zhang C, Feng S, Yu X, Zhang Y, Sun JP	10.1126/SCIENCE.ADD6220	2023-03-15	56200
Gs	αs	Human	Mini-Gs	61	β1	Human	γ2	Human	Cryo-EM	8HJ2	8HJ2_refined	3.8	GPR21	GPR21	A orphans	A (Rhodopsin)	Human	-	Nanobody-35	-	Apo (no ligand)	none	Apo (no ligand)	-	-	Lin X, Chen B, Wu Y, Han Y, Qi A, Wang J, Yang Z, Wei X, Zhao T, Wu L, Xie X, Sun J, Zheng J, Zhao S, Xu F	10.1038/S41467-023-35882-W	2023-03-15	56198
Gs	αs	Human	Mini-Gs	61	β1	Human	γ2	Human	Cryo-EM	8HIX	-	3.1	GPR21	GPR21	A orphans	A (Rhodopsin)	Human	-	Nanobody-35	-	Apo (no ligand)	none	Apo (no ligand)	-	-	Lin X, Chen B, Wu Y, Han Y, Qi A, Wang J, Yang Z, Wei X, Zhao T, Wu L, Xie X, Sun J, Zheng J, Zhao S, Xu F	10.1038/S41467-023-35882-W	2023-03-15	56198
Gs	αs	Human	Mini-Gs	61	β1	Human	γ2	Human	Cryo-EM	8HJ0	-	3.1	GPR21	GPR21	A orphans	A (Rhodopsin)	Human	-	Nanobody-35	-	Apo (no ligand)	none	Apo (no ligand)	-	-	Lin X, Chen B, Wu Y, Han Y, Qi A, Wang J, Yang Z, Wei X, Zhao T, Wu L, Xie X, Sun J, Zheng J, Zhao S, Xu F	10.1038/S41467-023-35882-W	2023-03-15	56198
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	8HS3	-	3.1	GPR20	GPR20	A orphans	A (Rhodopsin)	Human	BRIL	scFv16	-	Apo (no ligand)	none	Apo (no ligand)	-	-	Lin X, Jiang S, Wu Y, Wei X, Han GW, Wu L, Liu J, Chen B, Zhang Z, Zhao S, Cherezov V, Xu F	10.1038/S41421-023-00520-8	2023-03-08	56200
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	8HSC	-	3.2	GPR20	GPR20	A orphans	A (Rhodopsin)	Human	BRIL	Antibody fab fragment light chain Antibody fab fragment heavy chain scFv16	-	Apo (no ligand)	none	Apo (no ligand)	-	-	Lin X, Jiang S, Wu Y, Wei X, Han GW, Wu L, Liu J, Chen B, Zhang Z, Zhao S, Cherezov V, Xu F	10.1038/S41421-023-00520-8	2023-03-08	56200
Gq/11	αq	Human	-	61	β1	Human	γ2	Human	Cryo-EM	8G59	8G59_refined	2.6	FFAR4	FFA4	Free fatty acid	A (Rhodopsin)	Human	-	-	-	TUG-891 pubchem gtoplig chembl_ligand	small-molecule	Agonist	oleic acid, myristic acid, linoleic acid, α-linolenic acid	small-molecule	Mao C, Xiao P, Tao XN, Qin J, He QT, Zhang C, Guo SC, Du YQ, Chen LN, Shen DD, Yang ZS, Zhang HQ, Huang SM, He YH, Cheng J, Zhong YN, Shang P, Chen J, Zhang DL, Wang QL, Liu MX, Li GY, Guo Y, Xu HE, Wang C, Zhang C, Feng S, Yu X, Zhang Y, Sun JP	10.1126/SCIENCE.ADD6220	2023-03-08	56208
Gi/o	αi1	Human	-	63	β1	Human	γ2	Human	Cryo-EM	7Y66	-	2.9	C5AR1	C5a₁	Complement peptide	A (Rhodopsin)	Human	-	scFv16	-	BM213	peptide	Agonist	C5a, ribosomal protein S19, C5a des-Arg, C3a	peptide	Feng Y, Zhao C, Deng Y, Wang H, Ma L, Liu S, Tian X, Wang B, Bin Y, Chen P, Yan W, Fu P, Shao Z	10.1038/S41422-023-00779-2	2023-03-01	56200
Gi/o	αi2	Human	-	61	β1	Human	γ2	Bovine	Cryo-EM	7YK7	7YK7_refined	2.8	RL3R2	RXFP4	Relaxin family peptide	A (Rhodopsin)	Human	-	scFv16	-	DC591053 pubchem gtoplig	small-molecule	Agonist	INSL5, relaxin-3 (B chain), relaxin-3	peptide	Chen Y, Zhou Q, Wang J, Xu Y, Wang Y, Yan J, Wang Y, Zhu Q, Zhao F, Li C, Chen CW, Cai X, Bathgate RAD, Shen C, Eric Xu H, Yang D, Liu H, Wang MW	10.1038/S41467-023-36182-Z	2023-03-01	56201
Gi/o	αi2	Human	-	59	β1	Human	γ2	Bovine	Cryo-EM	7YK6	7YK6_refined	3.0	RL3R2	RXFP4	Relaxin family peptide	A (Rhodopsin)	Human	-	scFv16	-	CHEMBL4522365 chembl_ligand pubchem	small-molecule	Agonist	INSL5, relaxin-3 (B chain), relaxin-3	peptide	Chen Y, Zhou Q, Wang J, Xu Y, Wang Y, Yan J, Wang Y, Zhu Q, Zhao F, Li C, Chen CW, Cai X, Bathgate RAD, Shen C, Eric Xu H, Yang D, Liu H, Wang MW	10.1038/S41467-023-36182-Z	2023-03-01	56201
Gi/o	αi2	Human	-	58	β1	Bovine	γ2	Bovine	Cryo-EM	7YJ4	-	3.2	RL3R2	RXFP4	Relaxin family peptide	A (Rhodopsin)	Human	-	scFv16	-	Insulin-like peptide INSL5 B chain pubchem Insulin-like peptide INSL5 A chain pubchem	peptide peptide	Agonist	INSL5, relaxin-3 (B chain), relaxin-3	peptide	Chen Y, Zhou Q, Wang J, Xu Y, Wang Y, Yan J, Wang Y, Zhu Q, Zhao F, Li C, Chen CW, Cai X, Bathgate RAD, Shen C, Eric Xu H, Yang D, Liu H, Wang MW	10.1038/S41467-023-36182-Z	2023-03-01	56201
Gi/o	αi1	Human	-	63	β1	Human	γ2	Human	Cryo-EM	7Y67	7Y67_refined	2.8	C5AR1	C5a₁	Complement peptide	A (Rhodopsin)	Human	-	scFv16	-	C089	peptide	Agonist	C5a, ribosomal protein S19, C5a des-Arg, C3a	peptide	Feng Y, Zhao C, Deng Y, Wang H, Ma L, Liu S, Tian X, Wang B, Bin Y, Chen P, Yan W, Fu P, Shao Z	10.1038/S41422-023-00779-2	2023-03-01	56200
Gi/o	αi1	Human	-	63	β1	Human	γ2	Human	Cryo-EM	7Y64	-	2.9	C5AR1	C5a₁	Complement peptide	A (Rhodopsin)	Human	-	scFv16	-	C5a anaphylatoxin	peptide	Agonist	C5a, ribosomal protein S19, C5a des-Arg, C3a	peptide	Feng Y, Zhao C, Deng Y, Wang H, Ma L, Liu S, Tian X, Wang B, Bin Y, Chen P, Yan W, Fu P, Shao Z	10.1038/S41422-023-00779-2	2023-03-01	56200
Gi/o	αi1	Human	-	64	β1	Human	γ2	Human	Cryo-EM	7Y65	-	3.2	C5AR1	C5a₁	Complement peptide	A (Rhodopsin)	Human	-	scFv16	-	C5a	peptide	Agonist	C5a, ribosomal protein S19, C5a des-Arg, C3a	peptide	Feng Y, Zhao C, Deng Y, Wang H, Ma L, Liu S, Tian X, Wang B, Bin Y, Chen P, Yan W, Fu P, Shao Z	10.1038/S41422-023-00779-2	2023-03-01	56200
Gs	αs	Human	-	58	β1	Human	γ2	Human	Cryo-EM	8HMV	8HMV_refined	2.9	GPR21	GPR21	A orphans	A (Rhodopsin)	Human	-	Nanobody-35	-	Apo (no ligand)	none	Apo (no ligand)	-	-	Wong TS, Gao W, Chen G, Qiu C, He G, Ye F, Wu Z, Zeng Z, Du Y	10.1002/MCO2.205	2023-03-01	56198
Gs	αs2	Human	-	96	-	-	-	-	Cryo-EM	8EL7	-	2.8	-	-	-	-	-	-	-	Isoform 1 of Synembryn-B	-	-	-	-	-	Papasergi-Scott MM, Kwarcinski FE, Yu M, Panova O, Ovrutsky AM, Skiniotis G, Tall GG	36931277	2023-03-01	56198
Gs	αl	Human	-	100	-	-	-	-	Cryo-EM	8EL8	-	3.2	-	-	-	-	-	-	-	Isoform 1 of Synembryn-B	-	-	-	-	-	Papasergi-Scott MM, Kwarcinski FE, Yu M, Panova O, Ovrutsky AM, Skiniotis G, Tall GG	36931277	2023-03-01	56199
Gi/o	αi1	Human	-	64	β1	Human	γ2	Human	Cryo-EM	7XK8	7XK8_refined	3.3	NMUR2	NMU2	Neuromedin U	A (Rhodopsin)	Human	-	-	-	Neuromedin U-25 (human) pubchem	peptide	Agonist	neuromedin U-23, neuromedin S-33, neuromedin U-25, neuromedin S-36	peptide	Zhao W, Zhang W, Wang M, Lu M, Chen S, Tang T, Schnapp G, Wagner H, Brennauer A, Yi C, Chu X, Han S, Wu B, Zhao Q	10.1038/S41467-022-34814-4	2023-02-22	56200
Gi/o	αi1	Human	-	63	β1	Human	γ2	Human	Cryo-EM	7XK2	7XK2_refined	3.1	HCAR2	HCA₂	Hydroxycarboxylic acid	A (Rhodopsin)	Human	-	scFv16	-	MK 6892 pubchem gtoplig chembl_ligand pubchem	small-molecule	Agonist	butyric acid, β-D-hydroxybutyric acid	small-molecule	Yang Y, Kang HJ, Gao R, Wang J, Han GW, DiBerto JF, Wu L, Tong J, Qu L, Wu Y, Pileski R, Li X, Zhang XC, Zhao S, Kenakin T, Wang Q, Stevens RC, Peng W, Roth BL, Rao Z, Liu ZJ	10.1038/S41467-023-37177-6	2023-02-22	56200
Gq/11	αq	Human	-	98	β1	Human	γ2	Human	Cryo-EM	7W3Z	-	3.0	GRPR	BB₂	Bombesin	A (Rhodopsin)	Human	-	scFv16	-	Gastrin-releasing peptide pubchem	peptide	Agonist	gastrin-releasing peptide, neuromedin B, neuromedin C, gastrin releasing peptide(14-27) (human), GRP-(18-27)	peptide	-	-	2023-02-22	56208
Gq/11	αq	Human	-	79	β1	Human	γ2	Human	Cryo-EM	7W40	7W40_refined	3.0	GRPR	BB₂	Bombesin	A (Rhodopsin)	Human	-	scFv16	-	Bombesin	peptide	Agonist	gastrin-releasing peptide, neuromedin B, neuromedin C, gastrin releasing peptide(14-27) (human), GRP-(18-27)	peptide	Peng S, Zhan Y, Zhang D, Ren L, Chen A, Chen ZF, Zhang H	10.1073/PNAS.2216230120	2023-02-22	56208
Gs	αs	Human	-	59	β1	Human	γ2	Human	Cryo-EM	7XV3	7XV3_refined	2.8	GP174	GPR174	A orphans	A (Rhodopsin)	Human	-	-	-	(2~{S})-2-$l^{4}-azanyl-3-[[(2~{R})-3-octadecanoyloxy-2-oxidanyl-propoxy]-oxidanyl-oxidanylidene-$l^{6}-phosphanyl]oxy-propanoic acid pubchem	small-molecule	Agonist	lysophosphatidylserine	small-molecule	Liang J, Inoue A, Ikuta T, Xia R, Wang N, Kawakami K, Xu Z, Qian Y, Zhu X, Zhang A, Guo C, Huang Z, He Y	10.1038/S41467-023-36575-0	2023-02-15	56198
Gs	αs	Human	Gs fused to receptor	57	β1	Human	γ2	Human	Cryo-EM	7TMW	-	3.2	RXFP1	RXFP1	Relaxin family peptide	A (Rhodopsin)	Human	-	Nanobody-35	-	H2 relaxin pubchem chembl_ligand pubchem	small-molecule	Agonist	relaxin, relaxin-3, relaxin-1	peptide	-	-	2023-02-15	56198
G12/13	α13	Human	-	60	β1	Human	γ2	Human	Cryo-EM	8H8J	8H8J_refined	3.2	GPR35	GPR35	A orphans	A (Rhodopsin)	Human	-	scFv16	-	lodoxamide pubchem gtoplig chembl_ligand drug_central drugbank	small-molecule	Agonist	2-oleoyl-LPA, kynurenic acid, 1-Lyso-2-oleoyl-phosphatidic acid, 2-Oleoyllysophosphatydic acid	small-molecule	Duan J, Liu Q, Yuan Q, Ji Y, Zhu S, Tan Y, He X, Xu Y, Shi J, Cheng X, Jiang H, Eric Xu H, Jiang Y	10.1038/S41421-022-00499-8	2023-02-08	56213
Gi/o	αo	Human	-	62	β1	Human	γ2	Human	Cryo-EM	7T90	7T90_refined	3.3	ACM2	M₂	Acetylcholine (muscarinic)	A (Rhodopsin)	Human	-	scFv16	-	acetylcholine pubchem gtoplig chembl_ligand drugbank drug_central gtoplig pubchem	small-molecule	Agonist	acetylcholine	small-molecule	-	-	2023-01-25	56206
Gi/o	αo	Human	-	62	β1	Human	γ2	Human	Cryo-EM	7T94	-	3.2	ACM2	M₂	Acetylcholine (muscarinic)	A (Rhodopsin)	Human	-	Antibody fragment	-	acetylcholine pubchem gtoplig chembl_ligand drugbank drug_central gtoplig pubchem LY2119620 pubchem gtoplig chembl_ligand	small-molecule small-molecule	Agonist PAM	acetylcholine	small-molecule	-	-	2023-01-25	56206
Gi/o	αo	Human	-	62	β1	Human	γ2	Human	Cryo-EM	7T96	7T96_refined	3.2	ACM2	M₂	Acetylcholine (muscarinic)	A (Rhodopsin)	Human	-	scFv16	-	acetylcholine pubchem gtoplig chembl_ligand drugbank drug_central gtoplig pubchem LY2119620 pubchem gtoplig chembl_ligand	small-molecule small-molecule	Agonist PAM	acetylcholine	small-molecule	-	-	2023-01-25	56206
Gi/o	αo	Human	-	62	β1	Human	γ2	Human	Cryo-EM	7T8X	7T8X_refined	3.2	ACM2	M₂	Acetylcholine (muscarinic)	A (Rhodopsin)	Human	-	Antibody fragment	-	acetylcholine pubchem gtoplig chembl_ligand drugbank drug_central gtoplig pubchem	small-molecule	Agonist	acetylcholine	small-molecule	-	-	2023-01-25	56206
Gs	αs	Human	Mini-Gs	59	β1	Human	γ2	Human	Cryo-EM	8HDO	-	2.9	AA2BR	A_2B	Adenosine	A (Rhodopsin)	Human	-	Nanobody-35	-	BAY 60-6583 pubchem gtoplig chembl_ligand	small-molecule	Agonist	adenosine	small-molecule	Cai H, Xu Y, Guo S, He X, Sun J, Li X, Li C, Yin W, Cheng X, Jiang H, Xu HE, Xie X, Jiang Y	10.1038/S41421-022-00503-1	2023-01-18	56198
Gs	αs	Human	Mini-Gs	60	β1	Human	γ2	Human	Cryo-EM	8HDP	-	3.2	AA2BR	A_2B	Adenosine	A (Rhodopsin)	Human	-	Nanobody-35	-	adenosine pubchem gtoplig chembl_ligand drugbank drug_central pubchem	small-molecule	Agonist	adenosine	small-molecule	Cai H, Xu Y, Guo S, He X, Sun J, Li X, Li C, Yin W, Cheng X, Jiang H, Xu HE, Xie X, Jiang Y	10.1038/S41421-022-00503-1	2023-01-18	56198
Gs	αs	Human	-	59	β1	Human	γ2	Human	Cryo-EM	8GY7	-	3.3	ACTHR	MC₂	Melanocortin	A (Rhodopsin)	Human	BRIL	-	MRAP1	ACTH pubchem gtoplig chembl_ligand drugbank drug_central pubchem pubchem	peptide	Agonist	ACTH	peptide	Luo P, Feng W, Ma S, Dai A, Wu K, Chen X, Yuan Q, Cai X, Yang D, Wang MW, Eric Xu H, Jiang Y	10.1038/S41422-022-00751-6	2023-01-11	56198
Gq/11	αq	Human	-	58	β1	Rat	γ2	Bovine	Cryo-EM	7XW9	-	2.7	TRFR	TRH₁	Thyrotropin-releasing hormone	A (Rhodopsin)	Human	-	scFv16	-	TRH pubchem	peptide	Agonist	TRH	peptide	-	-	2022-12-28	56208
Gs	αs	Bovine	-	60	β1	Rat	γ2	Bovine	Cryo-EM	8HAO	-	3.8	PTH1R	PTH1	Parathyroid hormone	B1 (Secretin)	Human	-	Nanobody-35	-	teriparatide pubchem gtoplig chembl_ligand drugbank drug_central pubchem pubchem pubchem pubchem pubchem pubchem pubchem	peptide	Agonist	PTH, PTHrP, TIP39, PTHrP-(1-36)	peptide	Zhao LH, Yuan QN, Dai AT, He XH, Chen CW, Zhang C, Xu YW, Zhou Y, Wang MW, Yang DH, Xu HE	10.1038/S41401-022-01032-Z	2022-12-21	56215
Gs	αs	Bovine	-	60	β1	Rat	γ2	Bovine	Cryo-EM	8HA0	-	2.6	PTH1R	PTH1	Parathyroid hormone	B1 (Secretin)	Human	-	Nanobody-35	-	teriparatide pubchem gtoplig chembl_ligand drugbank drug_central pubchem pubchem pubchem pubchem pubchem pubchem pubchem	peptide	Agonist	PTH, PTHrP, TIP39, PTHrP-(1-36)	peptide	Zhao LH, Yuan QN, Dai AT, He XH, Chen CW, Zhang C, Xu YW, Zhou Y, Wang MW, Yang DH, Xu HE	10.1038/S41401-022-01032-Z	2022-12-21	56215
Gs	αs	Human	-	60	β1	Human	γ2	Human	Cryo-EM	7WCN	7WCN_refined	2.9	GP119	GPR119	GPR18, GPR55 and GPR119	A (Rhodopsin)	Human	-	Nanobody-35	-	AR231453 pubchem gtoplig chembl_ligand	small-molecule	Agonist	N-oleoylethanolamide, N-palmitoylethanolamine, SEA, anandamide	small-molecule	Qian Y, Wang J, Yang L, Liu Y, Wang L, Liu W, Lin Y, Yang H, Ma L, Ye S, Wu S, Qiao A	10.1038/S41467-022-34696-6	2022-12-21	56198
Gs	αs	Bovine	-	60	β1	Rat	γ2	Bovine	Cryo-EM	8HAF	-	3.3	PTH1R	PTH1	Parathyroid hormone	B1 (Secretin)	Human	-	Nanobody-35	-	PTHrP-(1-36) pubchem gtoplig	peptide	Agonist	PTH, PTHrP, TIP39, PTHrP-(1-36)	peptide	Zhao LH, Yuan QN, Dai AT, He XH, Chen CW, Zhang C, Xu YW, Zhou Y, Wang MW, Yang DH, Xu HE	10.1038/S41401-022-01032-Z	2022-12-21	56215
Gs	αs	Human	-	60	β1	Human	γ2	Human	Cryo-EM	7WCM	7WCM_refined	2.3	GP119	GPR119	GPR18, GPR55 and GPR119	A (Rhodopsin)	Human	-	Nanobody-35	-	MBX-2982 pubchem gtoplig chembl_ligand drugbank	small-molecule	Agonist	N-oleoylethanolamide, N-palmitoylethanolamine, SEA, anandamide	small-molecule	Qian Y, Wang J, Yang L, Liu Y, Wang L, Liu W, Lin Y, Yang H, Ma L, Ye S, Wu S, Qiao A	10.1038/S41467-022-34696-6	2022-12-21	56198
Gi/o	αi1	Human	-	64	β1	Rat	γ2	Bovine	Cryo-EM	8F7Q	-	3.2	OPRM	μ	Opioid	A (Rhodopsin)	Human	-	scFv16	-	β-endorphin pubchem gtoplig chembl_ligand pubchem	peptide	Agonist	dynorphin B, dynorphin A-(1-13), dynorphin A-(1-8), β-endorphin, [Met]enkephalin, dynorphin A, [Leu]enkephalin, endomorphin-1, endomorphin-2	peptide	Wang Y, Zhuang Y, DiBerto JF, Zhou XE, Schmitz GP, Yuan Q, Jain MK, Liu W, Melcher K, Jiang Y, Roth BL, Xu HE	10.1016/J.CELL.2022.12.026	2022-12-14	56200
Gi/o	αi1	Human	-	63	β1	Rat	γ2	Bovine	Cryo-EM	8F7R	-	3.3	OPRM	μ	Opioid	A (Rhodopsin)	Human	-	scFv16	-	endomorphin-1 pubchem gtoplig chembl_ligand	peptide	Agonist	dynorphin B, dynorphin A-(1-13), dynorphin A-(1-8), β-endorphin, [Met]enkephalin, dynorphin A, [Leu]enkephalin, endomorphin-1, endomorphin-2	peptide	Wang Y, Zhuang Y, DiBerto JF, Zhou XE, Schmitz GP, Yuan Q, Jain MK, Liu W, Melcher K, Jiang Y, Roth BL, Xu HE	10.1016/J.CELL.2022.12.026	2022-12-14	56200
Gi/o	αi1	Human	-	62	β1	Rat	γ2	Bovine	Cryo-EM	8F7S	8F7S_refined	3.0	OPRD	δ	Opioid	A (Rhodopsin)	Human	-	-	-	DELTORPHIN II chembl_ligand pubchem	protein	Agonist	dynorphin B, dynorphin A-(1-13), dynorphin A-(1-8), β-endorphin, α-neoendorphin, [Met]enkephalin, dynorphin A, [Leu]enkephalin, endomorphin-1	peptide	Wang Y, Zhuang Y, DiBerto JF, Zhou XE, Schmitz GP, Yuan Q, Jain MK, Liu W, Melcher K, Jiang Y, Roth BL, Xu HE	10.1016/J.CELL.2022.12.026	2022-12-14	56200
Gi/o	αi1	Human	-	64	β1	Rat	γ2	Bovine	Cryo-EM	8F7W	8F7W_refined	3.2	OPRK	κ	Opioid	A (Rhodopsin)	Human	-	scFv16	-	dynorphin A-(1-8) pubchem gtoplig chembl_ligand pubchem pubchem	peptide	Agonist	dynorphin B, dynorphin A-(1-13), dynorphin A-(1-8), β-endorphin, β-neoendorphin, α-neoendorphin, [Met]enkephalin, dynorphin A, [Leu]enkephalin, big dynorphin	peptide	Wang Y, Zhuang Y, DiBerto JF, Zhou XE, Schmitz GP, Yuan Q, Jain MK, Liu W, Melcher K, Jiang Y, Roth BL, Xu HE	10.1016/J.CELL.2022.12.026	2022-12-14	56200
Gi/o	αi1	Human	-	62	β1	Rat	γ2	Bovine	Cryo-EM	8F7X	8F7X_refined	3.3	OPRX	NOP	Opioid	A (Rhodopsin)	Human	-	scFv16	-	nociceptin/orphanin FQ pubchem gtoplig chembl_ligand gtoplig pubchem pubchem	peptide	Agonist	nociceptin/orphanin FQ	peptide	Wang Y, Zhuang Y, DiBerto JF, Zhou XE, Schmitz GP, Yuan Q, Jain MK, Liu W, Melcher K, Jiang Y, Roth BL, Xu HE	10.1016/J.CELL.2022.12.026	2022-12-14	56200
Gi/o	αi1	Human	-	61	β1	Human	γ2	Human	Cryo-EM	7T2H	-	3.2	OPRM	μ	Opioid	A (Rhodopsin)	Mouse	-	scFv16	-	LOFENTANIL chembl_ligand pubchem	small-molecule	Agonist	-	-	Qu Q, Huang W, Aydin D, Paggi JM, Seven AB, Wang H, Chakraborty S, Che T, DiBerto JF, Robertson MJ, Inoue A, Suomivuori CM, Roth BL, Majumdar S, Dror RO, Kobilka BK, Skiniotis G	10.1038/S41589-022-01208-Y	2022-12-07	56200
Gi/o	αi1	Human	-	61	β1	Human	γ2	Human	Cryo-EM	7U2K	-	3.3	OPRM	μ	Opioid	A (Rhodopsin)	Mouse	-	-	-	CHEMBL147044 chembl_ligand pubchem	small-molecule	Agonist	-	-	Faouzi A, Wang H, Zaidi SA, DiBerto JF, Che T, Qu Q, Robertson MJ, Madasu MK, El Daibani A, Varga BR, Zhang T, Ruiz C, Liu S, Xu J, Appourchaux K, Slocum ST, Eans SO, Cameron MD, Al-Hasani R, Pan YX, Roth BL, McLaughlin JP, Skiniotis G, Katritch V, Kobilka BK, Majumdar S	10.1038/S41586-022-05588-Y	2022-12-07	56200
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	7T2G	-	2.5	OPRM	μ	Opioid	A (Rhodopsin)	Mouse	BRIL	-	-	CHEMBL58362 chembl_ligand pubchem	small-molecule	Agonist	-	-	Qu Q, Huang W, Aydin D, Paggi JM, Seven AB, Wang H, Chakraborty S, Che T, DiBerto JF, Robertson MJ, Inoue A, Suomivuori CM, Roth BL, Majumdar S, Dror RO, Kobilka BK, Skiniotis G	10.1038/S41589-022-01208-Y	2022-12-07	56200
Gi/o	αo	Human	Mini-Go	61	β1	Human	γ2	Human	Cryo-EM	8E9X	-	2.7	ACM4	M₄	Acetylcholine (muscarinic)	A (Rhodopsin)	Human	-	scFv16	-	CHEMBL73538 chembl_ligand pubchem	small-molecule	Agonist	acetylcholine	small-molecule	Zhang S, Gumpper RH, Huang XP, Liu Y, Krumm BE, Cao C, Fay JF, Roth BL	10.1038/S41586-022-05489-0	2022-11-30	56206
Gq/11	αq	Human	Mini-Gq	56	β1	Human	γ2	Human	Cryo-EM	8E9Y	-	2.8	ACM3	M₃	Acetylcholine (muscarinic)	A (Rhodopsin)	Human	-	scFv16	-	Clozapine N-oxide pubchem	small-molecule	Agonist	acetylcholine	small-molecule	Zhang S, Gumpper RH, Huang XP, Liu Y, Krumm BE, Cao C, Fay JF, Roth BL	10.1038/S41586-022-05489-0	2022-11-30	56208
Gq/11	αq	Human	Mini-Gq	57	β1	Human	γ2	Human	Cryo-EM	8E9W	-	2.7	ACM3	M₃	Acetylcholine (muscarinic)	A (Rhodopsin)	Human	-	scFv16	-	CHEMBL73538 chembl_ligand pubchem	small-molecule	Agonist	acetylcholine	small-molecule	Zhang S, Gumpper RH, Huang XP, Liu Y, Krumm BE, Cao C, Fay JF, Roth BL	10.1038/S41586-022-05489-0	2022-11-30	56208
Gq/11	αq	Human	Mini-Gq	57	β1	Human	γ2	Human	Cryo-EM	8E9Z	-	2.7	ACM3	M₃	Acetylcholine (muscarinic)	A (Rhodopsin)	Human	-	scFv16	-	iperoxo pubchem gtoplig chembl_ligand	small-molecule	Agonist	acetylcholine	small-molecule	Zhang S, Gumpper RH, Huang XP, Liu Y, Krumm BE, Cao C, Fay JF, Roth BL	10.1038/S41586-022-05489-0	2022-11-30	56208
Gs	αs	Human	-	55	β1	Human	γ2	Human	Cryo-EM	8E3Z	8E3Z_refined	2.7	VIPR1	VPAC₁	VIP and PACAP	B1 (Secretin)	Human	-	Nanobody-35	-	Vasoactive intestinal polypeptide pubchem chembl_ligand pubchem pubchem	small-molecule	Agonist	secretin, PHM, PACAP-27, VIP, PACAP-38, PHI, GHRH	peptide	Piper SJ, Deganutti G, Lu J, Zhao P, Liang YL, Lu Y, Fletcher MM, Hossain MA, Christopoulos A, Reynolds CA, Danev R, Sexton PM, Wootten D	10.1038/S41467-022-34629-3	2022-11-23	56198
Gs	αs	Human	-	59	β1	Human	γ2	Human	Cryo-EM	8E3X	8E3X_refined	2.3	PACR	PAC₁	VIP and PACAP	B1 (Secretin)	Human	-	Nanobody-35	-	[Ac-His¹]PACAP-27 gtoplig chembl_ligand pubchem	peptide	Agonist	PHM, PACAP-27, VIP, PHV, PACAP-38, PHI	peptide	Piper SJ, Deganutti G, Lu J, Zhao P, Liang YL, Lu Y, Fletcher MM, Hossain MA, Christopoulos A, Reynolds CA, Danev R, Sexton PM, Wootten D	10.1038/S41467-022-34629-3	2022-11-23	56198
Gs	αs	Human	-	56	β1	Human	γ2	Human	Cryo-EM	8E3Y	-	2.3	VIPR1	VPAC₁	VIP and PACAP	B1 (Secretin)	Human	-	Nanobody-35	-	[Ac-His¹]PACAP-27 gtoplig chembl_ligand pubchem	peptide	Agonist	secretin, PHM, PACAP-27, VIP, PACAP-38, PHI, GHRH	peptide	Piper SJ, Deganutti G, Lu J, Zhao P, Liang YL, Lu Y, Fletcher MM, Hossain MA, Christopoulos A, Reynolds CA, Danev R, Sexton PM, Wootten D	10.1038/S41467-022-34629-3	2022-11-23	56198
G12/13	α12	Human	-	55	β1	Human	γ2	Human	Cryo-EM	7X10	-	2.9	AGRL3	ADGRL3	ADGRL	B2 (Adhesion)	Mouse	-	scFv16	-	Apo (no ligand)	none	Apo (no ligand)	-	-	Qian Y, Ma Z, Liu C, Li X, Zhu X, Wang N, Xu Z, Xia R, Liang J, Duan Y, Yin H, Xiong Y, Zhang A, Guo C, Chen Z, Huang Z, He Y	10.1016/J.MOLCEL.2022.10.009	2022-11-09	56212
Gi/o	αi1	Human	-	64	β1	Rat	γ2	Bovine	Cryo-EM	8EFL	8EFL_refined	3.2	OPRM	μ	Opioid	A (Rhodopsin)	Human	-	scFv16	-	CHEMBL4452384 chembl_ligand pubchem	small-molecule	Agonist	dynorphin B, dynorphin A-(1-13), dynorphin A-(1-8), β-endorphin, [Met]enkephalin, dynorphin A, [Leu]enkephalin, endomorphin-1, endomorphin-2	peptide	Zhuang Y, Wang Y, He B, He X, Zhou XE, Guo S, Rao Q, Yang J, Liu J, Zhou Q, Wang X, Liu M, Liu W, Jiang X, Yang D, Jiang H, Shen J, Melcher K, Chen H, Jiang Y, Cheng X, Wang MW, Xie X, Xu HE	10.1016/J.CELL.2022.09.041	2022-11-09	56200
Gi/o	αi1	Human	-	64	β1	Rat	γ2	Bovine	Cryo-EM	8EF5	-	3.3	OPRM	μ	Opioid	A (Rhodopsin)	Human	-	scFv16	-	fentanyl pubchem gtoplig chembl_ligand drugbank drug_central pubchem	small-molecule	Agonist	dynorphin B, dynorphin A-(1-13), dynorphin A-(1-8), β-endorphin, [Met]enkephalin, dynorphin A, [Leu]enkephalin, endomorphin-1, endomorphin-2	peptide	Zhuang Y, Wang Y, He B, He X, Zhou XE, Guo S, Rao Q, Yang J, Liu J, Zhou Q, Wang X, Liu M, Liu W, Jiang X, Yang D, Jiang H, Shen J, Melcher K, Chen H, Jiang Y, Cheng X, Wang MW, Xie X, Xu HE	10.1016/J.CELL.2022.09.041	2022-11-09	56200
Gi/o	αo	Human	-	63	β1	Rat	γ2	Mouse	Cryo-EM	7TS0	7TS0_refined	2.8	CRFR2	CRF₂	Corticotropin-releasing factor	B1 (Secretin)	Human	-	scFv16	-	Urocortin pubchem	peptide	Agonist	urocortin 1, urocortin 3, urocortin 2, corticotrophin-releasing hormone	peptide	Zhao LH, Lin J, Ji SY, Zhou XE, Mao C, Shen DD, He X, Xiao P, Sun J, Melcher K, Zhang Y, Yu X, Xu HE	10.1038/S41467-022-33851-3	2022-11-09	56206
Gi/o	αi1	Human	-	64	β1	Rat	γ2	Bovine	Cryo-EM	8EFO	-	2.8	OPRM	μ	Opioid	A (Rhodopsin)	Human	-	scFv16	-	PZM21 pubchem gtoplig chembl_ligand drugbank	small-molecule	Agonist	dynorphin B, dynorphin A-(1-13), dynorphin A-(1-8), β-endorphin, [Met]enkephalin, dynorphin A, [Leu]enkephalin, endomorphin-1, endomorphin-2	peptide	Zhuang Y, Wang Y, He B, He X, Zhou XE, Guo S, Rao Q, Yang J, Liu J, Zhou Q, Wang X, Liu M, Liu W, Jiang X, Yang D, Jiang H, Shen J, Melcher K, Chen H, Jiang Y, Cheng X, Wang MW, Xie X, Xu HE	10.1016/J.CELL.2022.09.041	2022-11-09	56200
Gi/o	αi1	Human	-	64	β1	Rat	γ2	Bovine	Cryo-EM	8EF6	8EF6_refined	3.2	OPRM	μ	Opioid	A (Rhodopsin)	Human	-	scFv16	-	morphine pubchem gtoplig chembl_ligand drugbank drug_central pubchem	small-molecule	Agonist	dynorphin B, dynorphin A-(1-13), dynorphin A-(1-8), β-endorphin, [Met]enkephalin, dynorphin A, [Leu]enkephalin, endomorphin-1, endomorphin-2	peptide	Zhuang Y, Wang Y, He B, He X, Zhou XE, Guo S, Rao Q, Yang J, Liu J, Zhou Q, Wang X, Liu M, Liu W, Jiang X, Yang D, Jiang H, Shen J, Melcher K, Chen H, Jiang Y, Cheng X, Wang MW, Xie X, Xu HE	10.1016/J.CELL.2022.09.041	2022-11-09	56200
Gi/o	αi1	Human	-	61	β1	Rat	γ2	Bovine	Cryo-EM	8EFQ	-	3.3	OPRM	μ	Opioid	A (Rhodopsin)	Human	-	-	-	DAMGO pubchem gtoplig chembl_ligand chembl_ligand	peptide	Agonist	dynorphin B, dynorphin A-(1-13), dynorphin A-(1-8), β-endorphin, [Met]enkephalin, dynorphin A, [Leu]enkephalin, endomorphin-1, endomorphin-2	peptide	Zhuang Y, Wang Y, He B, He X, Zhou XE, Guo S, Rao Q, Yang J, Liu J, Zhou Q, Wang X, Liu M, Liu W, Jiang X, Yang D, Jiang H, Shen J, Melcher K, Chen H, Jiang Y, Cheng X, Wang MW, Xie X, Xu HE	10.1016/J.CELL.2022.09.041	2022-11-09	56200
Gi/o	αi1	Human	-	64	β1	Rat	γ2	Bovine	Cryo-EM	8EFB	8EFB_refined	3.2	OPRM	μ	Opioid	A (Rhodopsin)	Human	-	scFv16	-	OLICERIDINE chembl_ligand pubchem drugbank pubchem	small-molecule	Agonist	dynorphin B, dynorphin A-(1-13), dynorphin A-(1-8), β-endorphin, [Met]enkephalin, dynorphin A, [Leu]enkephalin, endomorphin-1, endomorphin-2	peptide	Zhuang Y, Wang Y, He B, He X, Zhou XE, Guo S, Rao Q, Yang J, Liu J, Zhou Q, Wang X, Liu M, Liu W, Jiang X, Yang D, Jiang H, Shen J, Melcher K, Chen H, Jiang Y, Cheng X, Wang MW, Xie X, Xu HE	10.1016/J.CELL.2022.09.041	2022-11-09	56200
Gq/11	α11	Human	-	62	β1	Rat	γ2	Mouse	Cryo-EM	7TRY	-	3.7	CRFR2	CRF₂	Corticotropin-releasing factor	B1 (Secretin)	Human	-	-	-	Urocortin pubchem	peptide	Agonist	urocortin 1, urocortin 3, urocortin 2, corticotrophin-releasing hormone	peptide	Zhao LH, Lin J, Ji SY, Zhou XE, Mao C, Shen DD, He X, Xiao P, Sun J, Melcher K, Zhang Y, Yu X, Xu HE	10.1038/S41467-022-33851-3	2022-11-09	56209
Gq/11	αq	Human	Gs-mini-Gq chimera	57	β1	Human	γ2	Human	Cryo-EM	8DWC	-	2.9	MRGX1	MRGPRX1	A orphans	A (Rhodopsin)	Human	-	scFv16	-	Proenkephalin-A	peptide	Agonist	bovine adrenal medulla peptide 8-22	peptide	Liu Y, Cao C, Huang XP, Gumpper RH, Rachman MM, Shih SL, Krumm BE, Zhang S, Shoichet BK, Fay JF, Roth BL	10.1038/S41589-022-01173-6	2022-11-02	56208
Gq/11	αq	Human	Gs-mini-Gq chimera	57	β1	Human	γ2	Human	Cryo-EM	8DWH	8DWH_refined	3.3	MRGX1	MRGPRX1	A orphans	A (Rhodopsin)	Human	-	-	-	compound 16 [PMID: 31498617] pubchem gtoplig chembl_ligand	small-molecule	Agonist	bovine adrenal medulla peptide 8-22	peptide	Liu Y, Cao C, Huang XP, Gumpper RH, Rachman MM, Shih SL, Krumm BE, Zhang S, Shoichet BK, Fay JF, Roth BL	10.1038/S41589-022-01173-6	2022-11-02	56208
Gq/11	αq	Human	Gs-mini-Gq chimera	57	β1	Human	γ2	Human	Cryo-EM	8DWG	-	2.7	MRGX1	MRGPRX1	A orphans	A (Rhodopsin)	Human	-	scFv16	-	Proenkephalin-A CHEMBL5177388 chembl_ligand pubchem	peptide small-molecule	Agonist PAM	bovine adrenal medulla peptide 8-22	peptide	Liu Y, Cao C, Huang XP, Gumpper RH, Rachman MM, Shih SL, Krumm BE, Zhang S, Shoichet BK, Fay JF, Roth BL	10.1038/S41589-022-01173-6	2022-11-02	56208
Gi/o	αi1	Human	-	64	β1	Human	γ2	Human	Cryo-EM	7WYB	-	3.0	AGRL3	ADGRL3	ADGRL	B2 (Adhesion)	Mouse	-	scFv16	-	Apo (no ligand)	none	Apo (no ligand)	-	-	Qian Y, Ma Z, Liu C, Li X, Zhu X, Wang N, Xu Z, Xia R, Liang J, Duan Y, Yin H, Xiong Y, Zhang A, Guo C, Chen Z, Huang Z, He Y	10.1016/J.MOLCEL.2022.10.009	2022-10-26	56200
Gi/o	αi1	Human	-	61	β1	Human	γ2	Human	Cryo-EM	7WZ4	-	3.0	GPR88	GPR88	A orphans	A (Rhodopsin)	Human	-	scFv16	-	Apo (no ligand)	none	Apo (no ligand)	-	-	Chen G, Xu J, Inoue A, Schmidt MF, Bai C, Lu Q, Gmeiner P, Liu Z, Du Y	10.1038/S41467-022-30081-5	2022-10-26	56200
Gq/11	αq	Human	Mini-Gq	59	β1	Human	γ2	Human	Cryo-EM	7WY5	-	2.8	AGRL3	ADGRL3	ADGRL	B2 (Adhesion)	Mouse	-	Nanobody-35	-	Apo (no ligand)	none	Apo (no ligand)	-	-	Qian Y, Ma Z, Liu C, Li X, Zhu X, Wang N, Xu Z, Xia R, Liang J, Duan Y, Yin H, Xiong Y, Zhang A, Guo C, Chen Z, Huang Z, He Y	10.1016/J.MOLCEL.2022.10.009	2022-10-26	56208
Gs	αs	Human	Mini-Gs	59	β1	Human	γ2	Human	Cryo-EM	7WY8	-	2.8	AGRL3	ADGRL3	ADGRL	B2 (Adhesion)	Mouse	-	Nanobody-35	-	Apo (no ligand)	none	Apo (no ligand)	-	-	Qian Y, Ma Z, Liu C, Li X, Zhu X, Wang N, Xu Z, Xia R, Liang J, Duan Y, Yin H, Xiong Y, Zhang A, Guo C, Chen Z, Huang Z, He Y	10.1016/J.MOLCEL.2022.10.009	2022-10-26	56198
Gi/o	αo	Human	-	60	β1	Human	γ2	Human	Cryo-EM	7Y24	-	3.3	SSR2	SST2	Somatostatin	A (Rhodopsin)	Human	-	scFv16	-	Octreotide pubchem	peptide	Agonist	CST-17, SRIF-14, cortistatin-14, SRIF-28	peptide	Chen S, Teng X, Zheng S	10.1038/S41589-022-01130-3	2022-10-19	56206
Gq/11	αq	Human	Mini-Gq	60	β1	Human	γ2	Human	Cryo-EM	7Y27	7Y27_refined	3.5	SSR2	SST2	Somatostatin	A (Rhodopsin)	Human	-	scFv16	-	SOMATOSTATIN chembl_ligand pubchem	protein	Agonist	CST-17, SRIF-14, cortistatin-14, SRIF-28	peptide	Chen S, Teng X, Zheng S	10.1038/S41589-022-01130-3	2022-10-19	56208
Gq/11	αq	Human	Mini-Gq	60	β1	Human	γ2	Human	Cryo-EM	7Y26	7Y26_refined	3.3	SSR2	SST2	Somatostatin	A (Rhodopsin)	Human	-	scFv16	-	Octreotide pubchem	peptide	Agonist	CST-17, SRIF-14, cortistatin-14, SRIF-28	peptide	Chen S, Teng X, Zheng S	10.1038/S41589-022-01130-3	2022-10-19	56208
Gi/o	αi1	Human	-	58	β1	Human	γ2	Human	Cryo-EM	7Y89	-	3.0	GPR17	GPR17	A orphans	A (Rhodopsin)	Human	-	-	-	Apo (no ligand)	none	Apo (no ligand)	UDP-glucose, LTC₄, ATP, LTE₄, UDP-galactose, UDP, LTD₄	small-molecule	Ye F, Wong TS, Chen G, Zhang Z, Zhang B, Gan S, Gao W, Li J, Wu Z, Pan X, Du Y	10.1002/MCO2.159	2022-10-12	56200
Gi/o	αgust	Human	-	63	β1	Human	γ2	Human	Cryo-EM	7XP5	-	3.1	T2R46	TAS2R46	Taste 2	T2 (Taste 2)	Human	-	Nanobody-35	Endoglucanase H	Apo (no ligand)	none	Apo (no ligand)	-	-	Xu W, Wu L, Liu S, Liu X, Cao X, Zhou C, Zhang J, Fu Y, Guo Y, Wu Y, Tan Q, Wang L, Liu J, Jiang L, Fan Z, Pei Y, Yu J, Cheng J, Zhao S, Hao X, Liu ZJ, Hua T	10.1126/SCIENCE.ABO1633	2022-10-12	56205
Gi/o	αgust	Human	-	63	β1	Human	γ2	Human	Cryo-EM	7XP6	-	3.0	T2R46	TAS2R46	Taste 2	T2 (Taste 2)	Human	-	Nanobody-35	Endoglucanase H	strychnine pubchem gtoplig chembl_ligand drug_central drugbank gtoplig	small-molecule	Agonist	-	-	Xu W, Wu L, Liu S, Liu X, Cao X, Zhou C, Zhang J, Fu Y, Guo Y, Wu Y, Tan Q, Wang L, Liu J, Jiang L, Fan Z, Pei Y, Yu J, Cheng J, Zhao S, Hao X, Liu ZJ, Hua T	10.1126/SCIENCE.ABO1633	2022-10-12	56205
Gi/o	αgust	Human	-	63	β1	Human	γ2	Human	Cryo-EM	7XP4	-	3.0	T2R46	TAS2R46	Taste 2	T2 (Taste 2)	Human	-	Nanobody-35	Endoglucanase H	Apo (no ligand)	none	Apo (no ligand)	-	-	Xu W, Wu L, Liu S, Liu X, Cao X, Zhou C, Zhang J, Fu Y, Guo Y, Wu Y, Tan Q, Wang L, Liu J, Jiang L, Fan Z, Pei Y, Yu J, Cheng J, Zhao S, Hao X, Liu ZJ, Hua T	10.1126/SCIENCE.ABO1633	2022-10-12	56205
Gi/o	αi1	Human	-	63	β1	Rat	γ2	Bovine	Cryo-EM	7YU8	-	4.5	LPAR1	LPA₁	Lysophospholipid (LPA)	A (Rhodopsin)	Human	-	scFv16	-	[(2~{R})-2-[5-(2-hexylphenyl)pentanoylamino]-3-oxidanyl-propyl] dihydrogen phosphate pubchem	small-molecule	Agonist	1-O-Oleoyl-D-glycerol 3-phosphoric acid	small-molecule	Akasaka H, Tanaka T, Sano FK, Matsuzaki Y, Shihoya W, Nureki O	10.1038/S41467-022-33121-2	2022-10-05	56200
Gi/o	αi1	Human	-	63	β1	Rat	γ2	Bovine	Cryo-EM	7YU3	7YU3_refined	3.4	LPAR1	LPA₁	Lysophospholipid (LPA)	A (Rhodopsin)	Human	-	scFv16	-	[(2~{R})-2-[5-(2-hexylphenyl)pentanoylamino]-3-oxidanyl-propyl] dihydrogen phosphate pubchem	small-molecule	Agonist	1-O-Oleoyl-D-glycerol 3-phosphoric acid	small-molecule	Akasaka H, Tanaka T, Sano FK, Matsuzaki Y, Shihoya W, Nureki O	10.1038/S41467-022-33121-2	2022-10-05	56200
Gi/o	αi1	Human	-	63	β1	Rat	γ2	Bovine	Cryo-EM	7YU5	7YU5_refined	3.3	LPAR1	LPA₁	Lysophospholipid (LPA)	A (Rhodopsin)	Human	-	scFv16	-	[(2~{R})-2-[5-(2-hexylphenyl)pentanoylamino]-3-oxidanyl-propyl] dihydrogen phosphate pubchem	small-molecule	Agonist	1-O-Oleoyl-D-glycerol 3-phosphoric acid	small-molecule	Akasaka H, Tanaka T, Sano FK, Matsuzaki Y, Shihoya W, Nureki O	10.1038/S41467-022-33121-2	2022-10-05	56200
Gi/o	αi1	Human	-	63	β1	Rat	γ2	Bovine	Cryo-EM	7YU6	7YU6_refined	3.5	LPAR1	LPA₁	Lysophospholipid (LPA)	A (Rhodopsin)	Human	-	scFv16	-	[(2~{R})-2-[5-(2-hexylphenyl)pentanoylamino]-3-oxidanyl-propyl] dihydrogen phosphate pubchem	small-molecule	Agonist	1-O-Oleoyl-D-glycerol 3-phosphoric acid	small-molecule	Akasaka H, Tanaka T, Sano FK, Matsuzaki Y, Shihoya W, Nureki O	10.1038/S41467-022-33121-2	2022-10-05	56200
Gi/o	αi1	Human	-	63	β1	Rat	γ2	Bovine	Cryo-EM	7YU7	-	3.8	LPAR1	LPA₁	Lysophospholipid (LPA)	A (Rhodopsin)	Human	-	scFv16	-	[(2~{R})-2-[5-(2-hexylphenyl)pentanoylamino]-3-oxidanyl-propyl] dihydrogen phosphate pubchem	small-molecule	Agonist	1-O-Oleoyl-D-glycerol 3-phosphoric acid	small-molecule	Akasaka H, Tanaka T, Sano FK, Matsuzaki Y, Shihoya W, Nureki O	10.1038/S41467-022-33121-2	2022-10-05	56200
G12/13	α13	Human	-	55	β1	Human	γ2	Human	Cryo-EM	7WY0	-	2.8	AGRF1	ADGRF1	ADGRF	B2 (Adhesion)	Human	-	scFv16	-	Apo (no ligand)	none	Apo (no ligand)	-	-	Zhu X, Qian Y, Li X, Xu Z, Xia R, Wang N, Liang J, Yin H, Zhang A, Guo C, Wang G, He Y	10.1038/S41467-022-33173-4	2022-09-28	56213
G12/13	α12	Human	Mini-G12	55	β1	Human	γ2	Human	Cryo-EM	7WZ7	-	2.8	AGRF1	ADGRF1	ADGRF	B2 (Adhesion)	Human	-	scFv16	-	Apo (no ligand)	none	Apo (no ligand)	-	-	Zhu X, Qian Y, Li X, Xu Z, Xia R, Wang N, Liang J, Yin H, Zhang A, Guo C, Wang G, He Y	10.1038/S41467-022-33173-4	2022-09-28	56212
Gi/o	αo	Human	-	58	β1	Human	γ2	Human	Cryo-EM	7W6P	-	3.5	ADA2A	α_2A	Adrenoceptors	A (Rhodopsin)	Human	-	scFv16	-	N-pyridin-4-ylisoquinolin-4-amine pubchem	small-molecule	Agonist	(-)-adrenaline, (-)-noradrenaline	small-molecule	Fink EA, Xu J, Hubner H, Braz JM, Seemann P, Avet C, Craik V, Weikert D, Schmidt MF, Webb CM, Tolmachova NA, Moroz YS, Huang XP, Kalyanaraman C, Gahbauer S, Chen G, Liu Z, Jacobson MP, Irwin JJ, Bouvier M, Du Y, Shoichet BK, Basbaum AI, Gmeiner P	10.1126/SCIENCE.ABN7065	2022-09-28	56206
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	7X2V	-	3.1	AGRF1	ADGRF1	ADGRF	B2 (Adhesion)	Human	-	scFv16	-	Apo (no ligand)	none	Apo (no ligand)	-	-	Zhu X, Qian Y, Li X, Xu Z, Xia R, Wang N, Liang J, Yin H, Zhang A, Guo C, Wang G, He Y	10.1038/S41467-022-33173-4	2022-09-28	56200
Gi/o	αi1	Human	-	64	β1	Human	γ2	Human	Cryo-EM	7VIH	7VIH_refined	3.0	S1PR1	S1P₁	Lysophospholipid (S1P)	A (Rhodopsin)	Human	-	scFv16	-	icanbelimod pubchem gtoplig chembl_ligand	small-molecule	Agonist	dihydrosphingosine 1-phosphate, sphingosylphosphorylcholine, sphingosine 1-phosphate	small-molecule	Yu L, He L, Gan B, Ti R, Xiao Q, Hu H, Zhu L, Wang S, Ren R	10.1073/PNAS.2117716119	2022-09-28	56200
Gi/o	αi1	Human	-	63	β1	Human	γ2	Human	Cryo-EM	7VIG	7VIG_refined	2.9	S1PR1	S1P₁	Lysophospholipid (S1P)	A (Rhodopsin)	Human	-	scFv16	-	icanbelimod pubchem gtoplig chembl_ligand	small-molecule	Agonist	dihydrosphingosine 1-phosphate, sphingosylphosphorylcholine, sphingosine 1-phosphate	small-molecule	Yu L, He L, Gan B, Ti R, Xiao Q, Hu H, Zhu L, Wang S, Ren R	10.1073/PNAS.2117716119	2022-09-28	56200
Gi/o	αi1	Human	-	64	β1	Human	γ2	Human	Cryo-EM	7VIE	7VIE_refined	2.9	S1PR1	S1P₁	Lysophospholipid (S1P)	A (Rhodopsin)	Human	-	scFv16	-	sphingosine 1-phosphate pubchem gtoplig chembl_ligand pubchem	small-molecule	Agonist	dihydrosphingosine 1-phosphate, sphingosylphosphorylcholine, sphingosine 1-phosphate	small-molecule	Yu L, He L, Gan B, Ti R, Xiao Q, Hu H, Zhu L, Wang S, Ren R	10.1073/PNAS.2117716119	2022-09-28	56200
Gi/o	αi1	Human	-	64	β1	Human	γ2	Human	Cryo-EM	7VIF	7VIF_refined	2.8	S1PR1	S1P₁	Lysophospholipid (S1P)	A (Rhodopsin)	Human	-	scFv16	-	(S)-FTY720-phosphate pubchem gtoplig chembl_ligand	small-molecule	Agonist	dihydrosphingosine 1-phosphate, sphingosylphosphorylcholine, sphingosine 1-phosphate	small-molecule	Yu L, He L, Gan B, Ti R, Xiao Q, Hu H, Zhu L, Wang S, Ren R	10.1073/PNAS.2117716119	2022-09-28	56200
Gi/o	αo	Human	-	59	β1	Human	γ2	Human	Cryo-EM	7W7E	-	3.4	ADA2A	α_2A	Adrenoceptors	A (Rhodopsin)	Human	-	scFv16	-	5-(3-Bicyclo[4.2.0]octa-1,3,5-trienyl)-1,2,3,6-tetrahydropyridine pubchem	small-molecule	Agonist	(-)-adrenaline, (-)-noradrenaline	small-molecule	Fink EA, Xu J, Hubner H, Braz JM, Seemann P, Avet C, Craik V, Weikert D, Schmidt MF, Webb CM, Tolmachova NA, Moroz YS, Huang XP, Kalyanaraman C, Gahbauer S, Chen G, Liu Z, Jacobson MP, Irwin JJ, Bouvier M, Du Y, Shoichet BK, Basbaum AI, Gmeiner P	10.1126/SCIENCE.ABN7065	2022-09-28	56206
Gq/11	αq	Human	-	60	β1	Human	γ2	Human	Cryo-EM	7WXU	-	2.9	AGRF1	ADGRF1	ADGRF	B2 (Adhesion)	Human	-	Nanobody-35	-	Apo (no ligand)	none	Apo (no ligand)	-	-	Zhu X, Qian Y, Li X, Xu Z, Xia R, Wang N, Liang J, Yin H, Zhang A, Guo C, Wang G, He Y	10.1038/S41467-022-33173-4	2022-09-28	56208
Gs	αs	Human	Mini-Gs	59	β1	Human	γ2	Human	Cryo-EM	7WXW	-	2.8	AGRF1	ADGRF1	ADGRF	B2 (Adhesion)	Human	-	Nanobody-35	-	Apo (no ligand)	none	Apo (no ligand)	-	-	Zhu X, Qian Y, Li X, Xu Z, Xia R, Wang N, Liang J, Yin H, Zhang A, Guo C, Wang G, He Y	10.1038/S41467-022-33173-4	2022-09-28	56198
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	7VFX	7VFX_refined	2.8	FPR1	FPR1	Formylpeptide	A (Rhodopsin)	Human	-	scFv16	-	Peptide agonist fMet-Ile-Phe-Leu pubchem	peptide	Agonist	fMet-Leu-Phe, cathepsin G, spinorphin, annexin I	peptide	Chen G, Wang X, Liao Q, Ge Y, Jiao H, Chen Q, Liu Y, Lyu W, Zhu L, van Zundert GCP, Robertson MJ, Skiniotis G, Du Y, Hu H, Ye RD	10.1038/S41467-022-32822-Y	2022-09-21	56200
Gq/11	αq	Human	Gi2-mini-Gq chimera	58	β1	Human	γ2	Human	Cryo-EM	7SRR	-	2.9	5HT2B	5-HT_2B	5-Hydroxytryptamine	A (Rhodopsin)	Human	-	scFv16	-	Lysergide pubchem gtoplig chembl_ligand drugbank drug_central	small-molecule	Agonist	5-hydroxytryptamine	small-molecule	Cao C, Barros-Alvarez X, Zhang S, Kim K, Damgen MA, Panova O, Suomivuori CM, Fay JF, Zhong X, Krumm BE, Gumpper RH, Seven AB, Robertson MJ, Krogan NJ, Huttenhain R, Nichols DE, Dror RO, Skiniotis G, Roth BL	10.1016/J.NEURON.2022.08.006	2022-09-21	56208
Gi/o	αi1	Human	-	63	β1	Human	γ2	Human	Cryo-EM	7X5H	7X5H_refined	3.1	5HT5A	5-HT_5A	5-Hydroxytryptamine	A (Rhodopsin)	Human	BRIL	scFv16	-	5-CT pubchem gtoplig chembl_ligand	small-molecule	Agonist	5-hydroxytryptamine	small-molecule	Tan Y, Xu P, Huang S, Yang G, Zhou F, He X, Ma H, Xu HE, Jiang Y	10.1038/S41421-022-00412-3	2022-09-14	56200
Gi/o	αi1	Human	-	63	β1	Bovine	γ2	Bovine	Cryo-EM	7XAU	-	3.0	SSR2	SST2	Somatostatin	A (Rhodopsin)	Human	-	scFv16	-	Octreotide	peptide	Agonist	CST-17, SRIF-14, cortistatin-14, SRIF-28	peptide	Bo Q, Yang F, Li Y, Meng X, Zhang H, Zhou Y, Ling S, Sun D, Lv P, Liu L, Shi P, Tian C	10.1038/S41421-022-00405-2	2022-08-31	56200
Gi/o	αi1	Human	-	63	β1	Bovine	γ2	Bovine	Cryo-EM	7XAV	7XAV_refined	2.9	SSR2	SST2	Somatostatin	A (Rhodopsin)	Human	-	scFv16	-	lanreotide pubchem gtoplig drugbank	peptide	Agonist	CST-17, SRIF-14, cortistatin-14, SRIF-28	peptide	Bo Q, Yang F, Li Y, Meng X, Zhang H, Zhou Y, Ling S, Sun D, Lv P, Liu L, Shi P, Tian C	10.1038/S41421-022-00405-2	2022-08-31	56200
Gi/o	αi1	Human	-	63	β1	Bovine	γ2	Bovine	Cryo-EM	7XAT	7XAT_refined	2.9	SSR2	SST2	Somatostatin	A (Rhodopsin)	Human	-	scFv16	-	SOMATOSTATIN chembl_ligand pubchem	protein	Agonist	CST-17, SRIF-14, cortistatin-14, SRIF-28	peptide	Bo Q, Yang F, Li Y, Meng X, Zhang H, Zhou Y, Ling S, Sun D, Lv P, Liu L, Shi P, Tian C	10.1038/S41421-022-00405-2	2022-08-31	56200
Gq/11	αq	Human	-	57	β1	Bovine	γ2	Bovine	Cryo-EM	7X1T	-	3.3	TRFR	TRH₁	Thyrotropin-releasing hormone	A (Rhodopsin)	Human	-	scFv16	-	taltirelin pubchem gtoplig chembl_ligand	small-molecule	Agonist	TRH	peptide	Yang F, Zhang H, Meng X, Li Y, Zhou Y, Ling S, Sun D, Lv P, Liu L, Shi P, Tian C	10.1038/S41422-022-00646-6	2022-08-31	56208
Gq/11	αq	Human	-	57	β1	Bovine	γ2	Bovine	Cryo-EM	7X1U	7X1U_refined	3.2	TRFR	TRH₁	Thyrotropin-releasing hormone	A (Rhodopsin)	Human	-	scFv16	-	TRH pubchem	peptide	Agonist	TRH	peptide	-	-	2022-08-31	56208
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	7X9Y	7X9Y_refined	3.1	CCR3	CCR3	Chemokine	A (Rhodopsin)	Human	-	scFv16	-	Apo (no ligand)	none	Apo (no ligand)	CXCL11, CCL13, CCL11, CCL26, CCL8, CXCL10, CCL2, CXCL9, CCL7, CCL28, CCL5, CCL24, CCL15	peptide	Shao Z, Tan Y, Shen Q, Hou L, Yao B, Qin J, Xu P, Mao C, Chen LN, Zhang H, Shen DD, Zhang C, Li W, Du X, Li F, Chen ZH, Jiang Y, Xu HE, Ying S, Ma H, Zhang Y, Shen H	10.1038/S41421-022-00403-4	2022-08-24	56200
Gi/o	αi1	Human	-	65	β1	Human	γ2	Human	Cryo-EM	7XA3	7XA3_refined	2.9	CCR2	CCR2	Chemokine	A (Rhodopsin)	Human	-	scFv16	-	C-C motif chemokine 2	peptide	Agonist	CCL13, CCL11, CCL26, CCL8, CCL2, CCL7, CCL24, CCL16	peptide	Shao Z, Tan Y, Shen Q, Hou L, Yao B, Qin J, Xu P, Mao C, Chen LN, Zhang H, Shen DD, Zhang C, Li W, Du X, Li F, Chen ZH, Jiang Y, Xu HE, Ying S, Ma H, Zhang Y, Shen H	10.1038/S41421-022-00403-4	2022-08-24	56200
Gq/11	αq	Human	Gi2-mini-Gq chimera	57	β1	Human	γ2	Human	Cryo-EM	8DPH	-	3.2	5HT2C	5-HT_2C	5-Hydroxytryptamine	A (Rhodopsin)	Human	-	scFv16	-	lorcaserin pubchem gtoplig chembl_ligand drugbank drug_central	small-molecule	Agonist	5-hydroxytryptamine	small-molecule	Gumpper RH, Fay JF, Roth BL	10.1016/J.CELREP.2022.111211	2022-08-24	56208
Gq/11	αq	Human	Gi2-mini-Gq chimera	57	β1	Human	γ2	Human	Cryo-EM	8DPG	-	3.6	5HT2C	5-HT_2C	5-Hydroxytryptamine	A (Rhodopsin)	Human	-	scFv16	-	psilocin pubchem gtoplig chembl_ligand	small-molecule	Agonist	5-hydroxytryptamine	small-molecule	Gumpper RH, Fay JF, Roth BL	10.1016/J.CELREP.2022.111211	2022-08-24	56208
Gq/11	αq	Human	Gi2-mini-Gq chimera	57	β1	Human	γ2	Human	Cryo-EM	8DPF	-	2.8	5HT2C	5-HT_2C	5-Hydroxytryptamine	A (Rhodopsin)	Human	-	scFv16	-	lorcaserin pubchem gtoplig chembl_ligand drugbank drug_central	small-molecule	Agonist	5-hydroxytryptamine	small-molecule	Gumpper RH, Fay JF, Roth BL	10.1016/J.CELREP.2022.111211	2022-08-24	56208
Gq/11	αq	Human	Gi2-mini-Gq chimera	57	β1	Human	γ2	Human	Cryo-EM	8DPI	-	3.4	5HT2C	5-HT_2C	5-Hydroxytryptamine	A (Rhodopsin)	Human	-	scFv16	-	lorcaserin pubchem gtoplig chembl_ligand drugbank drug_central	small-molecule	Agonist	5-hydroxytryptamine	small-molecule	Gumpper RH, Fay JF, Roth BL	10.1016/J.CELREP.2022.111211	2022-08-24	56208
Gs	αs	Human	-	60	β1	Human	γ2	Human	Cryo-EM	7XZ6	-	2.8	GP119	GPR119	GPR18, GPR55 and GPR119	A (Rhodopsin)	Human	BRIL	Nanobody-35	-	APD668 pubchem gtoplig chembl_ligand	small-molecule	Agonist	N-oleoylethanolamide, N-palmitoylethanolamine, SEA, anandamide	small-molecule	Xu P, Huang S, Guo S, Yun Y, Cheng X, He X, Cai P, Lan Y, Zhou H, Jiang H, Jiang Y, Xie X, Xu HE	10.1038/S41594-022-00816-5	2022-08-24	56198
Gs	αs	Human	-	59	β1	Human	γ2	Human	Cryo-EM	7YP7	-	3.1	AGRG2	ADGRG2	ADGRG	B2 (Adhesion)	Mouse	-	Nanobody-35	-	Apo (no ligand)	none	Apo (no ligand)	-	-	-	-	2022-08-24	56198
Gs	αs	Human	-	60	β1	Human	γ2	Human	Cryo-EM	7XW5	-	3.0	TSHR	TSH	Glycoprotein hormone	A (Rhodopsin)	Human	-	Nanobody-35	-	Thyrotropin subunit beta Glycoprotein hormones alpha chain N-[4-[[5-[(2S)-3-benzyl-5-hydroxy-4-oxo-1,2-dihydroquinazolin-2-yl]-2-methoxyphenyl]methoxy]phenyl]acetamide pubchem	protein protein small-molecule	Agonist	TSH	peptide	Duan J, Xu P, Luan X, Ji Y, He X, Song N, Yuan Q, Jin Y, Cheng X, Jiang H, Zheng J, Zhang S, Jiang Y, Xu HE	10.1038/S41586-022-05173-3	2022-08-24	56198
Gs	αs	Human	-	60	β1	Human	γ2	Human	Cryo-EM	7XZ5	-	3.1	GP119	GPR119	GPR18, GPR55 and GPR119	A (Rhodopsin)	Human	BRIL	Nanobody-35	-	(4R,7R,18E)-4,7-dihydroxy-N,N,N-trimethyl-10-oxo-3,5,9-trioxa-4-phosphaheptacos-18-en-1-aminium 4-oxide pubchem	small-molecule	Agonist	N-oleoylethanolamide, N-palmitoylethanolamine, SEA, anandamide	small-molecule	Xu P, Huang S, Guo S, Yun Y, Cheng X, He X, Cai P, Lan Y, Zhou H, Jiang H, Jiang Y, Xie X, Xu HE	10.1038/S41594-022-00816-5	2022-08-24	56198
Gi/o	αi1	Human	-	38	β1	Human	γ2	Human	Cryo-EM	7WU9	7WU9_refined	3.4	PE2R3	EP₃	Prostanoid	A (Rhodopsin)	Human	-	scFv16	-	Apo (no ligand)	none	Apo (no ligand)	PGE₁, PGF_2α, PGI₂, PGE₂, thromboxane A₂, PGD₂	small-molecule	Suno R, Sugita Y, Morimoto K, Takazaki H, Tsujimoto H, Hirose M, Suno-Ikeda C, Nomura N, Hino T, Inoue A, Iwasaki K, Kato T, Iwata S, Kobayashi T	10.1016/J.CELREP.2022.111323	2022-08-17	56200
Gs	αs	Human	-	59	β1	Human	γ2	Human	Cryo-EM	7XW6	-	2.8	TSHR	TSH	Glycoprotein hormone	A (Rhodopsin)	Human	-	Nanobody-35	-	M22 antibody heavy chain M22 antibody light chain N-[4-[[5-[(2S)-3-benzyl-5-hydroxy-4-oxo-1,2-dihydroquinazolin-2-yl]-2-methoxyphenyl]methoxy]phenyl]acetamide pubchem	protein protein small-molecule	Agonist	TSH	peptide	Duan J, Xu P, Luan X, Ji Y, He X, Song N, Yuan Q, Jin Y, Cheng X, Jiang H, Zheng J, Zhang S, Jiang Y, Xu HE	10.1038/S41586-022-05173-3	2022-08-17	56198
Gi/o	αo	Human	-	59	β1	Human	γ2	Human	Cryo-EM	7QVM	-	3.3	OXYR	OT	Vasopressin and oxytocin	A (Rhodopsin)	Human	-	scFv16	-	oxytocin pubchem gtoplig chembl_ligand drugbank drug_central gtoplig pubchem	peptide	Agonist	oxytocin, vasopressin	peptide	Waltenspuhl Y, Ehrenmann J, Vacca S, Thom C, Medalia O, Pluckthun A	10.1038/S41467-022-31325-0	2022-08-10	56206
Gs	αs	Human	-	57	β1	Human	γ2	Human	Cryo-EM	7XKF	-	2.4	AGRG2	ADGRG2	ADGRG	B2 (Adhesion)	Mouse	-	Nanobody-35	-	PRASTERONE chembl_ligand pubchem	small-molecule	Agonist	-	-	Lin H, Xiao P, Bu RQ, Guo S, Yang Z, Yuan D, Zhu ZL, Zhang CX, He QT, Zhang C, Ping YQ, Zhao RJ, Ma CS, Liu CH, Zhang XN, Jiang D, Huang S, Xi YT, Zhang DL, Xue CY, Yang BS, Li JY, Lin HC, Zeng XH, Zhao H, Xu WM, Yi F, Liu Z, Sun JP, Yu X	10.1038/S41589-022-01084-6	2022-08-10	56198
Gs	αs	Human	Mini-Gs	60	β1	Human	γ2	Human	Cryo-EM	7XKE	-	2.9	AGRG2	ADGRG2	ADGRG	B2 (Adhesion)	Mouse	-	Nanobody-35	-	PRASTERONE chembl_ligand pubchem	small-molecule	Agonist	-	-	Lin H, Xiao P, Bu RQ, Guo S, Yang Z, Yuan D, Zhu ZL, Zhang CX, He QT, Zhang C, Ping YQ, Zhao RJ, Ma CS, Liu CH, Zhang XN, Jiang D, Huang S, Xi YT, Zhang DL, Xue CY, Yang BS, Li JY, Lin HC, Zeng XH, Zhao H, Xu WM, Yi F, Liu Z, Sun JP, Yu X	10.1038/S41589-022-01084-6	2022-08-10	56198
Gs	αs	Human	-	57	β1	Human	γ2	Human	Cryo-EM	7XKD	-	2.4	AGRG2	ADGRG2	ADGRG	B2 (Adhesion)	Mouse	-	Nanobody-35	-	PRASTERONE chembl_ligand pubchem	small-molecule	Agonist	-	-	Lin H, Xiao P, Bu RQ, Guo S, Yang Z, Yuan D, Zhu ZL, Zhang CX, He QT, Zhang C, Ping YQ, Zhao RJ, Ma CS, Liu CH, Zhang XN, Jiang D, Huang S, Xi YT, Zhang DL, Xue CY, Yang BS, Li JY, Lin HC, Zeng XH, Zhao H, Xu WM, Yi F, Liu Z, Sun JP, Yu X	10.1038/S41589-022-01084-6	2022-08-10	56198
Gi/o	αi1	Human	-	63	β1	Human	γ2	Human	Cryo-EM	7XMT	7XMT_refined	2.8	SSR4	SST4	Somatostatin	A (Rhodopsin)	Human	-	scFv16	-	J-2156 pubchem gtoplig chembl_ligand	small-molecule	Agonist	CST-17, SRIF-14, cortistatin-14, SRIF-28	peptide	Zhao W, Han S, Qiu N, Feng W, Lu M, Zhang W, Wang M, Zhou Q, Chen S, Xu W, Du J, Chu X, Yi C, Dai A, Hu L, Shen MY, Sun Y, Zhang Q, Ma Y, Zhong W, Yang D, Wang MW, Wu B, Zhao Q	10.1038/S41422-022-00679-X	2022-08-03	56200
Gi/o	αi1	Human	-	63	β1	Human	γ2	Human	Cryo-EM	7XMR	7XMR_refined	3.1	SSR2	SST2	Somatostatin	A (Rhodopsin)	Human	-	-	-	SOMATOSTATIN chembl_ligand pubchem	protein	Agonist	CST-17, SRIF-14, cortistatin-14, SRIF-28	peptide	Zhao W, Han S, Qiu N, Feng W, Lu M, Zhang W, Wang M, Zhou Q, Chen S, Xu W, Du J, Chu X, Yi C, Dai A, Hu L, Shen MY, Sun Y, Zhang Q, Ma Y, Zhong W, Yang D, Wang MW, Wu B, Zhao Q	10.1038/S41422-022-00679-X	2022-08-03	56200
Gi/o	αi1	Human	-	63	β1	Human	γ2	Human	Cryo-EM	7XMS	-	2.9	SSR4	SST4	Somatostatin	A (Rhodopsin)	Human	-	scFv16	-	SOMATOSTATIN chembl_ligand pubchem	protein	Agonist	CST-17, SRIF-14, cortistatin-14, SRIF-28	peptide	Zhao W, Han S, Qiu N, Feng W, Lu M, Zhang W, Wang M, Zhou Q, Chen S, Xu W, Du J, Chu X, Yi C, Dai A, Hu L, Shen MY, Sun Y, Zhang Q, Ma Y, Zhong W, Yang D, Wang MW, Wu B, Zhao Q	10.1038/S41422-022-00679-X	2022-08-03	56200
Gs	αs	Human	-	58	β1	Rat	γ2	Bovine	Cryo-EM	7VVL	7VVL_refined	2.8	PTH1R	PTH1	Parathyroid hormone	B1 (Secretin)	Human	-	Nanobody-35	-	teriparatide pubchem gtoplig chembl_ligand drugbank drug_central pubchem pubchem pubchem pubchem pubchem pubchem pubchem	peptide	Agonist	PTH, PTHrP, TIP39, PTHrP-(1-36)	peptide	Kobayashi K, Kawakami K, Kusakizako T, Miyauchi H, Tomita A, Kobayashi K, Shihoya W, Yamashita K, Nishizawa T, Kato HE, Inoue A, Nureki O	10.1016/J.MOLCEL.2022.07.003	2022-08-03	56198
Gs	αs	Human	-	59	β1	Rat	γ2	Bovine	Cryo-EM	7VVJ	7VVJ_refined	3.2	PTH1R	PTH1	Parathyroid hormone	B1 (Secretin)	Human	-	Nanobody-35	-	PTHrP[1-36]	peptide	Agonist	PTH, PTHrP, TIP39, PTHrP-(1-36)	peptide	Kobayashi K, Kawakami K, Kusakizako T, Miyauchi H, Tomita A, Kobayashi K, Shihoya W, Yamashita K, Nishizawa T, Kato HE, Inoue A, Nureki O	10.1016/J.MOLCEL.2022.07.003	2022-08-03	56198
Gs	αs	Human	Mini-Gs	56	β1	Human	γ2	Human	Cryo-EM	7T9I	-	2.9	TSHR	TSH	Glycoprotein hormone	A (Rhodopsin)	Human	-	Nanobody-35	-	Thyrotropin subunit beta Glycoprotein hormones alpha chain	protein protein	Agonist	TSH	peptide	Faust B, Billesbolle CB, Suomivuori CM, Singh I, Zhang K, Hoppe N, Pinto AFM, Diedrich JK, Muftuoglu Y, Szkudlinski MW, Saghatelian A, Dror RO, Cheng Y, Manglik A	10.1038/S41586-022-05159-1	2022-08-03	56198
Gs	αs	Human	-	58	β1	Rat	γ2	Bovine	Cryo-EM	7VVO	7VVO_refined	4.1	PTH1R	PTH1	Parathyroid hormone	B1 (Secretin)	Human	-	Nanobody-35	-	Parathyroid hormone	peptide	Agonist	PTH, PTHrP, TIP39, PTHrP-(1-36)	peptide	Kobayashi K, Kawakami K, Kusakizako T, Miyauchi H, Tomita A, Kobayashi K, Shihoya W, Yamashita K, Nishizawa T, Kato HE, Inoue A, Nureki O	10.1016/J.MOLCEL.2022.07.003	2022-08-03	56198
Gs	αs	Human	-	58	β1	Rat	γ2	Bovine	Cryo-EM	7VVM	7VVM_refined	3.2	PTH1R	PTH1	Parathyroid hormone	B1 (Secretin)	Human	-	Nanobody-35	-	Parathyroid hormone	peptide	Agonist	PTH, PTHrP, TIP39, PTHrP-(1-36)	peptide	Kobayashi K, Kawakami K, Kusakizako T, Miyauchi H, Tomita A, Kobayashi K, Shihoya W, Yamashita K, Nishizawa T, Kato HE, Inoue A, Nureki O	10.1016/J.MOLCEL.2022.07.003	2022-08-03	56198
Gs	αs	Human	Mini-Gs	56	β1	Human	γ2	Human	Cryo-EM	7UTZ	-	2.4	TSHR	TSH	Glycoprotein hormone	A (Rhodopsin)	Human	-	Nanobody-35	-	Thyrotropin subunit beta Glycoprotein hormones alpha chain analog TR1402	protein protein	Agonist	TSH	peptide	Faust B, Billesbolle CB, Suomivuori CM, Singh I, Zhang K, Hoppe N, Pinto AFM, Diedrich JK, Muftuoglu Y, Szkudlinski MW, Saghatelian A, Dror RO, Cheng Y, Manglik A	10.1038/S41586-022-05159-1	2022-08-03	56198
Gs	αs	Human	-	58	β1	Rat	γ2	Bovine	Cryo-EM	7VVK	-	3.3	PTH1R	PTH1	Parathyroid hormone	B1 (Secretin)	Human	-	Nanobody-35	-	teriparatide pubchem gtoplig chembl_ligand drugbank drug_central pubchem pubchem pubchem pubchem pubchem pubchem pubchem	peptide	Agonist	PTH, PTHrP, TIP39, PTHrP-(1-36)	peptide	Kobayashi K, Kawakami K, Kusakizako T, Miyauchi H, Tomita A, Kobayashi K, Shihoya W, Yamashita K, Nishizawa T, Kato HE, Inoue A, Nureki O	10.1016/J.MOLCEL.2022.07.003	2022-08-03	56198
Gs	αs	Human	Mini-Gs	56	β1	Human	γ2	Human	Cryo-EM	7T9N	-	2.9	TSHR	TSH	Glycoprotein hormone	A (Rhodopsin)	Human	-	M22 Fab light chain M22 Fab heavy chain Nanobody-35	-	M22 antibody heavy chain M22 antibody light chain	protein protein	Agonist	TSH	peptide	Faust B, Billesbolle CB, Suomivuori CM, Singh I, Zhang K, Hoppe N, Pinto AFM, Diedrich JK, Muftuoglu Y, Szkudlinski MW, Saghatelian A, Dror RO, Cheng Y, Manglik A	10.1038/S41586-022-05159-1	2022-08-03	56198
Gs	αs	Human	-	58	β1	Rat	γ2	Bovine	Cryo-EM	7VVN	7VVN_refined	3.8	PTH1R	PTH1	Parathyroid hormone	B1 (Secretin)	Human	-	Nanobody-35	-	teriparatide pubchem gtoplig chembl_ligand drugbank drug_central pubchem pubchem pubchem pubchem pubchem pubchem pubchem	peptide	Agonist	PTH, PTHrP, TIP39, PTHrP-(1-36)	peptide	Kobayashi K, Kawakami K, Kusakizako T, Miyauchi H, Tomita A, Kobayashi K, Shihoya W, Yamashita K, Nishizawa T, Kato HE, Inoue A, Nureki O	10.1016/J.MOLCEL.2022.07.003	2022-08-03	56198
Gi/o	αi1	Human	-	64	β1	Human	γ2	Human	Cryo-EM	7W0O	7W0O_refined	3.8	APJ	apelin	Apelin	A (Rhodopsin)	Human	BRIL	scFv16	-	Apelin receptor early endogenous ligand	peptide	Agonist	apelin-13, apelin-36, apelin-17, Elabela/Toddler-21, Elabela/Toddler-32, Elabela/Toddler-11, apelin receptor early endogenous ligand, [Pyr¹]apelin-13	peptide	Yue Y, Liu L, Wu LJ, Wu Y, Wang L, Li F, Liu J, Han GW, Chen B, Lin X, Brouillette RL, Breault E, Longpre JM, Shi S, Lei H, Sarret P, Stevens RC, Hanson MA, Xu F	10.1038/S41594-022-00797-5	2022-07-27	56200
Gi/o	αi1	Human	-	64	β1	Human	γ2	Human	Cryo-EM	7W0P	7W0P_refined	3.2	APJ	apelin	Apelin	A (Rhodopsin)	Human	BRIL	scFv16	-	Apelin receptor early endogenous ligand	peptide	Agonist	apelin-13, apelin-36, apelin-17, Elabela/Toddler-21, Elabela/Toddler-32, Elabela/Toddler-11, apelin receptor early endogenous ligand, [Pyr¹]apelin-13	peptide	Yue Y, Liu L, Wu LJ, Wu Y, Wang L, Li F, Liu J, Han GW, Chen B, Lin X, Brouillette RL, Breault E, Longpre JM, Shi S, Lei H, Sarret P, Stevens RC, Hanson MA, Xu F	10.1038/S41594-022-00797-5	2022-07-27	56200
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	7XTA	7XTA_refined	3.2	5HT4R	5-HT₄	5-Hydroxytryptamine	A (Rhodopsin)	Human	BRIL	scFv16	-	5-hydroxytryptamine pubchem gtoplig chembl_ligand drugbank	small-molecule	Agonist	5-hydroxytryptamine	small-molecule	Huang S, Xu P, Shen DD, Simon IA, Mao C, Tan Y, Zhang H, Harpsoe K, Li H, Zhang Y, You C, Yu X, Jiang Y, Zhang Y, Gloriam DE, Xu HE	10.1016/J.MOLCEL.2022.05.031	2022-07-27	56200
Gi/o	αi1	Human	-	64	β1	Human	γ2	Human	Cryo-EM	7W0N	-	4.2	APJ	apelin	Apelin	A (Rhodopsin)	Human	BRIL	scFv16	-	Apelin receptor early endogenous ligand	peptide	Agonist	apelin-13, apelin-36, apelin-17, Elabela/Toddler-21, Elabela/Toddler-32, Elabela/Toddler-11, apelin receptor early endogenous ligand, [Pyr¹]apelin-13	peptide	Yue Y, Liu L, Wu LJ, Wu Y, Wang L, Li F, Liu J, Han GW, Chen B, Lin X, Brouillette RL, Breault E, Longpre JM, Shi S, Lei H, Sarret P, Stevens RC, Hanson MA, Xu F	10.1038/S41594-022-00797-5	2022-07-27	56200
Gi/o	αi1	Human	-	64	β1	Human	γ2	Human	Cryo-EM	7W0L	7W0L_refined	3.6	APJ	apelin	Apelin	A (Rhodopsin)	Human	BRIL	scFv16	-	(1R,2S)-N-[4-(2,6-dimethoxyphenyl)-5-(6-methylpyridin-2-yl)-1,2,4-triazol-3-yl]-1-(5-methylpyrimidin-2-yl)-1-oxidanyl-propane-2-sulfonamide pubchem	small-molecule	Agonist	apelin-13, apelin-36, apelin-17, Elabela/Toddler-21, Elabela/Toddler-32, Elabela/Toddler-11, apelin receptor early endogenous ligand, [Pyr¹]apelin-13	peptide	Yue Y, Liu L, Wu LJ, Wu Y, Wang L, Li F, Liu J, Han GW, Chen B, Lin X, Brouillette RL, Breault E, Longpre JM, Shi S, Lei H, Sarret P, Stevens RC, Hanson MA, Xu F	10.1038/S41594-022-00797-5	2022-07-27	56200
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	7W0M	7W0M_refined	3.7	APJ	apelin	Apelin	A (Rhodopsin)	Human	BRIL	scFv16	-	(1R,2S)-N-[4-(2,6-dimethoxyphenyl)-5-(6-methylpyridin-2-yl)-1,2,4-triazol-3-yl]-1-(5-methylpyrimidin-2-yl)-1-oxidanyl-propane-2-sulfonamide pubchem	small-molecule	Agonist	apelin-13, apelin-36, apelin-17, Elabela/Toddler-21, Elabela/Toddler-32, Elabela/Toddler-11, apelin receptor early endogenous ligand, [Pyr¹]apelin-13	peptide	Yue Y, Liu L, Wu LJ, Wu Y, Wang L, Li F, Liu J, Han GW, Chen B, Lin X, Brouillette RL, Breault E, Longpre JM, Shi S, Lei H, Sarret P, Stevens RC, Hanson MA, Xu F	10.1038/S41594-022-00797-5	2022-07-27	56200
Gs	αs	Human	-	61	β1	Human	γ2	Human	Cryo-EM	7XTC	7XTC_refined	3.2	5HT7R	5-HT₇	5-Hydroxytryptamine	A (Rhodopsin)	Human	BRIL	Nanobody-35	-	5-CT pubchem gtoplig chembl_ligand	small-molecule	Agonist	5-hydroxytryptamine	small-molecule	Huang S, Xu P, Shen DD, Simon IA, Mao C, Tan Y, Zhang H, Harpsoe K, Li H, Zhang Y, You C, Yu X, Jiang Y, Zhang Y, Gloriam DE, Xu HE	10.1016/J.MOLCEL.2022.05.031	2022-07-27	56198
Gs	αs	Human	-	60	β1	Human	γ2	Human	Cryo-EM	7XT8	-	3.1	5HT4R	5-HT₄	5-Hydroxytryptamine	A (Rhodopsin)	Human	BRIL	Nanobody-35	-	5-hydroxytryptamine pubchem gtoplig chembl_ligand drugbank	small-molecule	Agonist	5-hydroxytryptamine	small-molecule	Huang S, Xu P, Shen DD, Simon IA, Mao C, Tan Y, Zhang H, Harpsoe K, Li H, Zhang Y, You C, Yu X, Jiang Y, Zhang Y, Gloriam DE, Xu HE	10.1016/J.MOLCEL.2022.05.031	2022-07-27	56198
Gs	αs	Bovine	-	51	β1	Bovine	γ2	Bovine	Cryo-EM	8DCS	-	2.5	ADRB1	β₁	Adrenoceptors	A (Rhodopsin)	Wild turkey	T4-Lysozyme	Nanobody-35	-	Cyanopindolol pubchem	small-molecule	Antagonist	-	-	Su M, Paknejad N, Zhu L, Wang J, Do HN, Miao Y, Liu W, Hite RK, Huang XY	10.1038/S41467-022-31823-1	2022-07-27	56215
Gs	αs	Human	-	60	β1	Human	γ2	Human	Cryo-EM	7XT9	-	3.2	5HT4R	5-HT₄	5-Hydroxytryptamine	A (Rhodopsin)	Human	BRIL	-	-	5-hydroxytryptamine pubchem gtoplig chembl_ligand drugbank	small-molecule	Agonist	5-hydroxytryptamine	small-molecule	Huang S, Xu P, Shen DD, Simon IA, Mao C, Tan Y, Zhang H, Harpsoe K, Li H, Zhang Y, You C, Yu X, Jiang Y, Zhang Y, Gloriam DE, Xu HE	10.1016/J.MOLCEL.2022.05.031	2022-07-27	56198
Gs	αs	Human	-	60	β1	Human	γ2	Human	Cryo-EM	7XTB	7XTB_refined	3.3	5HT6R	5-HT₆	5-Hydroxytryptamine	A (Rhodopsin)	Human	BRIL	Nanobody-35	-	5-hydroxytryptamine pubchem gtoplig chembl_ligand drugbank	small-molecule	Agonist	5-hydroxytryptamine	small-molecule	Huang S, Xu P, Shen DD, Simon IA, Mao C, Tan Y, Zhang H, Harpsoe K, Li H, Zhang Y, You C, Yu X, Jiang Y, Zhang Y, Gloriam DE, Xu HE	10.1016/J.MOLCEL.2022.05.031	2022-07-27	56198
Gs	αs	Bovine	-	51	β1	Bovine	γ2	Bovine	Cryo-EM	8DCR	-	2.6	ADRB1	β₁	Adrenoceptors	A (Rhodopsin)	Wild turkey	T4-Lysozyme	Nanobody-35	-	Dobutamine pubchem	small-molecule	Agonist (partial)	-	-	Su M, Paknejad N, Zhu L, Wang J, Do HN, Miao Y, Liu W, Hite RK, Huang XY	10.1038/S41467-022-31823-1	2022-07-27	56215
Gi/o	αi1	Human	-	62	β1	Mouse	γ2	Mouse	Cryo-EM	7Y15	7Y15_refined	2.9	MRGRD	MRGPRD	A orphans	A (Rhodopsin)	Human	BRIL	scFv16	-	Apo (no ligand)	none	Apo (no ligand)	β-alanine	small-molecule	Suzuki S, Iida M, Hiroaki Y, Tanaka K, Kawamoto A, Kato T, Oshima A	10.1038/S42003-022-03668-3	2022-07-20	56200
Gi/o	αo	Human	Mini-Go	60	β1	Human	γ2	Human	Cryo-EM	7UM5	7UM5_refined	2.7	5HT5A	5-HT_5A	5-Hydroxytryptamine	A (Rhodopsin)	Human	-	scFv16	-	5-CT pubchem gtoplig chembl_ligand	small-molecule	Agonist	5-hydroxytryptamine	small-molecule	Zhang S, Chen H, Zhang C, Yang Y, Popov P, Liu J, Krumm BE, Cao C, Kim K, Xiong Y, Katritch V, Shoichet BK, Jin J, Fay JF, Roth BL	10.1038/S41594-022-00796-6	2022-07-20	56206
Gi/o	αo	Human	Mini-Go	60	β1	Human	γ2	Human	Cryo-EM	7UM6	-	2.8	5HT5A	5-HT_5A	5-Hydroxytryptamine	A (Rhodopsin)	Human	-	scFv16	-	lisuride pubchem gtoplig chembl_ligand drugbank drug_central pubchem	small-molecule	Agonist	5-hydroxytryptamine	small-molecule	Zhang S, Chen H, Zhang C, Yang Y, Popov P, Liu J, Krumm BE, Cao C, Kim K, Xiong Y, Katritch V, Shoichet BK, Jin J, Fay JF, Roth BL	10.1038/S41594-022-00796-6	2022-07-20	56206
Gi/o	αo	Human	Mini-Go	60	β1	Human	γ2	Human	Cryo-EM	7UM7	7UM7_refined	2.8	5HT5A	5-HT_5A	5-Hydroxytryptamine	A (Rhodopsin)	Human	-	scFv16	-	methylergonovine pubchem gtoplig chembl_ligand drugbank drug_central pubchem	small-molecule	Agonist	5-hydroxytryptamine	small-molecule	Zhang S, Chen H, Zhang C, Yang Y, Popov P, Liu J, Krumm BE, Cao C, Kim K, Xiong Y, Katritch V, Shoichet BK, Jin J, Fay JF, Roth BL	10.1038/S41594-022-00796-6	2022-07-20	56206
Gi/o	αi1	Human	-	62	β1	Mouse	γ2	Mouse	Cryo-EM	7Y12	-	3.1	MRGRD	MRGPRD	A orphans	A (Rhodopsin)	Human	BRIL	scFv16	-	β-alanine pubchem gtoplig chembl_ligand drugbank pubchem	small-molecule	Agonist	β-alanine	small-molecule	Suzuki S, Iida M, Hiroaki Y, Tanaka K, Kawamoto A, Kato T, Oshima A	10.1038/S42003-022-03668-3	2022-07-20	56200
Gq/11	αq	Human	-	61	β1	Human	γ2	Human	Cryo-EM	7XOX	7XOX_refined	3.1	GASR	CCK₂	Cholecystokinin	A (Rhodopsin)	Human	-	scFv16	-	CCK-8 pubchem gtoplig chembl_ligand drug_central drugbank	peptide	Agonist	CCK-39, desulfated gastrin-14, gastrin-71, desulfated gastrin-71, desulfated gastrin-17, gastrin-17, desulfated gastrin-34, desulfated cholecystokinin-8, gastrin-14, CCK-4, CCK-58, gastrin-34, CCK-8, CCK-33	peptide	Ding Y, Zhang H, Liao YY, Chen LN, Ji SY, Qin J, Mao C, Shen DD, Lin L, Wang H, Zhang Y, Li XM	10.1038/S41421-022-00420-3	2022-07-20	56208
Gq/11	αq	Human	-	61	β1	Human	γ2	Human	Cryo-EM	7XOW	7XOW_refined	3.1	GASR	CCK₂	Cholecystokinin	A (Rhodopsin)	Human	-	scFv16	-	desulfated gastrin-17 pubchem gtoplig chembl_ligand pubchem	peptide	Agonist	CCK-39, desulfated gastrin-14, gastrin-71, desulfated gastrin-71, desulfated gastrin-17, gastrin-17, desulfated gastrin-34, desulfated cholecystokinin-8, gastrin-14, CCK-4, CCK-58, gastrin-34, CCK-8, CCK-33	peptide	Ding Y, Zhang H, Liao YY, Chen LN, Ji SY, Qin J, Mao C, Shen DD, Lin L, Wang H, Zhang Y, Li XM	10.1038/S41421-022-00420-3	2022-07-20	56208
Gs	αs	Human	-	58	β1	Human	γ2	Human	Cryo-EM	7XOU	-	3.2	CCKAR	CCK₁	Cholecystokinin	A (Rhodopsin)	Human	-	Nanobody-35	-	CCK-8 pubchem gtoplig chembl_ligand drug_central drugbank	peptide	Agonist	CCK-39, gastrin-17, desulfated cholecystokinin-8, CCK-4, CCK-58, CCK-8, CCK-33	peptide	Ding Y, Zhang H, Liao YY, Chen LN, Ji SY, Qin J, Mao C, Shen DD, Lin L, Wang H, Zhang Y, Li XM	10.1038/S41421-022-00420-3	2022-07-20	56198
Gs	αs	Human	-	58	β1	Human	γ2	Human	Cryo-EM	7XOV	-	3.0	CCKAR	CCK₁	Cholecystokinin	A (Rhodopsin)	Human	-	Nanobody-35	-	SR146131 pubchem gtoplig chembl_ligand	small-molecule	Agonist	CCK-39, gastrin-17, desulfated cholecystokinin-8, CCK-4, CCK-58, CCK-8, CCK-33	peptide	Ding Y, Zhang H, Liao YY, Chen LN, Ji SY, Qin J, Mao C, Shen DD, Lin L, Wang H, Zhang Y, Li XM	10.1038/S41421-022-00420-3	2022-07-20	56198
Gi/o	αi1	Human	-	61	β1	Human	γ2	Human	Cryo-EM	7XBW	7XBW_refined	2.8	CX3C1	CX₃CR1	Chemokine	A (Rhodopsin)	Human	-	-	-	Apo (no ligand)	none	Apo (no ligand)	CX₃CL1	peptide	Lu M, Zhao W, Han S, Lin X, Xu T, Tan Q, Wang M, Yi C, Chu X, Yang W, Zhu Y, Wu B, Zhao Q	10.1126/SCIADV.ABN8048	2022-07-13	56200
Gi/o	αi1	Human	-	60	β1	Human	γ2	Human	Cryo-EM	7WJ5	7WJ5_refined	3.7	SSR2	SST2	Somatostatin	A (Rhodopsin)	Human	BRIL	scFv16	-	SOMATOSTATIN chembl_ligand pubchem	protein	Agonist	CST-17, SRIF-14, cortistatin-14, SRIF-28	peptide	Heo Y, Yoon E, Jeon YE, Yun JH, Ishimoto N, Woo H, Park SY, Song JJ, Lee W	10.7554/ELIFE.76823	2022-07-13	56200
Gi/o	αi1	Human	-	61	β1	Human	γ2	Human	Cryo-EM	7XBX	-	3.4	CX3C1	CX₃CR1	Chemokine	A (Rhodopsin)	Human	-	-	-	CX3CL1	peptide	Agonist	CX₃CL1	peptide	-	-	2022-07-13	56200
Gq/11	αq	Human	-	60	β1	Human	γ2	Human	Cryo-EM	7XBD	7XBD_refined	3.1	GALR2	GAL₂	Galanin	A (Rhodopsin)	Human	-	scFv16	-	Galanin, Human pubchem	peptide	Agonist	galanin, spexin-1, galanin-like peptide	peptide	Heo Y, Ishimoto N, Jeon YE, Yun JH, Ohki M, Anraku Y, Sasaki M, Kita S, Fukuhara H, Ikuta T, Kawakami K, Inoue A, Maenaka K, Tame JRH, Lee W, Park SY	10.1371/JOURNAL.PBIO.3001714	2022-07-13	56208
Gq/11	αq	Human	Gi2-mini-Gq chimera	60	β1	Human	γ2	Human	Cryo-EM	7RAN	-	3.5	5HT2A	5-HT_2A	5-Hydroxytryptamine	A (Rhodopsin)	Human	-	scFv16	-	3-[(3R)-3-methyl-1,2,3,6-tetrahydropyridin-1-ium-5-yl]-1H-pyrrolo[2,3-b]pyridine pubchem	small-molecule	Agonist	tryptamine, 5-hydroxytryptamine	small-molecule	Kaplan AL, Confair DN, Kim K, Barros-Alvarez X, Rodriguiz RM, Yang Y, Kweon OS, Che T, McCorvy JD, Kamber DN, Phelan JP, Martins LC, Pogorelov VM, DiBerto JF, Slocum ST, Huang XP, Kumar JM, Robertson MJ, Panova O, Seven AB, Wetsel AQ, Wetsel WC, Irwin JJ, Skiniotis G, Shoichet BK, Roth BL, Ellman JA	10.1038/S41586-022-05258-Z	2022-07-06	56208
Gs	αs	Human	-	58	β1	Human	γ2	Human	Cryo-EM	7XTQ	7XTQ_refined	3.2	GPBAR	GPBA	Bile acid	A (Rhodopsin)	Human	-	Nanobody-35	-	CHEMBL2181246 chembl_ligand pubchem	small-molecule	Agonist	lithocholic acid, deoxycholic acid, cholic acid, chenodeoxycholic acid	small-molecule	Ma L, Yang F, Wu X, Mao C, Guo L, Miao T, Zang SK, Jiang X, Shen DD, Wei T, Zhou H, Wei Q, Li S, Shu Q, Feng S, Jiang C, Chu B, Du L, Sun JP, Yu X, Zhang Y, Zhang P	10.1073/PNAS.2117054119	2022-07-06	56198
Gq/11	αq	Human	-	58	β1	Human	γ2	Human	Cryo-EM	7XJK	7XJK_refined	3.3	GALR2	GAL₂	Galanin	A (Rhodopsin)	Human	-	scFv16	-	Galanin, Human pubchem	peptide	Agonist	galanin, spexin-1, galanin-like peptide	peptide	Jiang W, Zheng S	10.1073/PNAS.2121465119	2022-06-29	56208
Gq/11	αq	Human	-	58	β1	Human	γ2	Human	Cryo-EM	7XJL	7XJL_refined	3.5	GALR2	GAL₂	Galanin	A (Rhodopsin)	Human	-	scFv16	-	Spexin pubchem	small-molecule	Agonist	galanin, spexin-1, galanin-like peptide	peptide	Jiang W, Zheng S	10.1073/PNAS.2121465119	2022-06-29	56208
Gs	αs	Human	-	60	β1	Rat	γ2	Human	Cryo-EM	7X8S	7X8S_refined	3.1	GLP1R	GLP-1	Glucagon	B1 (Secretin)	Human	-	Nanobody-35	-	WB4-24 pubchem gtoplig chembl_ligand	small-molecule	Agonist	glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37)	peptide	Cong Z, Zhou Q, Li Y, Chen LN, Zhang ZC, Liang A, Liu Q, Wu X, Dai A, Xia T, Wu W, Zhang Y, Yang D, Wang MW	10.1073/PNAS.2200155119	2022-06-29	56198
Gs	αs	Human	-	58	β1	Human	γ2	Human	Cryo-EM	7X2C	7X2C_refined	3.2	DRD1	D₁	Dopamine	A (Rhodopsin)	Human	-	Nanobody-35	-	fenoldopam pubchem gtoplig chembl_ligand drugbank drug_central pubchem gtoplig chembl_ligand pubchem pubchem gtoplig chembl_ligand pubchem pubchem	small-molecule	Agonist	noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, dopamine, 5-hydroxytryptamine	small-molecule	Teng X, Chen S, Nie Y, Xiao P, Yu X, Shao Z, Zheng S	10.1038/S41467-022-30929-W	2022-06-29	56198
Gs	αs	Human	-	59	β1	Rat	γ2	Human	Cryo-EM	7X8R	-	2.6	GLP1R	GLP-1	Glucagon	B1 (Secretin)	Human	-	Nanobody-35	-	CHEMBL2158411 chembl_ligand pubchem	small-molecule	Agonist	glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37)	peptide	Cong Z, Zhou Q, Li Y, Chen LN, Zhang ZC, Liang A, Liu Q, Wu X, Dai A, Xia T, Wu W, Zhang Y, Yang D, Wang MW	10.1073/PNAS.2200155119	2022-06-29	56198
Gi/o	αi2	Human	-	63	β1	Human	γ2	Human	Cryo-EM	7WV9	-	3.4	CNR1	CB₁	Cannabinoid	A (Rhodopsin)	Human	-	scFv16	-	CP55940 pubchem gtoplig chembl_ligand gtoplig 6-methyl-3-[(1S)-2-nitro-1-thiophen-2-yl-ethyl]-2-phenyl-1H-indole pubchem	small-molecule small-molecule	Agonist PAM	2-arachidonoylglycerol, anandamide	small-molecule	Yang X, Wang X, Xu Z, Wu C, Zhou Y, Wang Y, Lin G, Li K, Wu M, Xia A, Liu J, Cheng L, Zou J, Yan W, Shao Z, Yang S	10.1038/S41589-022-01038-Y	2022-06-15	56201
Gq/11	αq	Human	-	60	β1	Human	γ2	Human	Cryo-EM	7WKD	-	3.0	TRFR	TRH₁	Thyrotropin-releasing hormone	A (Rhodopsin)	Human	-	scFv16	-	TRH pubchem	peptide	Agonist	TRH	peptide	Xu Y, Cai H, You C, He X, Yuan Q, Jiang H, Cheng X, Jiang Y, Xu HE	10.1038/S41422-022-00641-X	2022-06-15	56208
Gs	αs	Human	-	60	β1	Human	γ2	Human	Cryo-EM	7F1O	-	3.1	DRD1	D₁	Dopamine	A (Rhodopsin)	Human	-	Nanobody-35	-	dopamine pubchem gtoplig chembl_ligand drugbank drug_central pubchem	small-molecule	Agonist	noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, dopamine, 5-hydroxytryptamine	small-molecule	Teng X, Chen S, Wang Q, Chen Z, Wang X, Huang N, Zheng S	10.1126/SCIADV.ABO4158	2022-06-15	56198
Gs	αs	Human	-	58	β1	Human	γ2	Human	Cryo-EM	7X2F	7X2F_refined	3.0	DRD1	D₁	Dopamine	A (Rhodopsin)	Human	-	Nanobody-35	-	dopamine pubchem gtoplig chembl_ligand drugbank drug_central pubchem mevidalen pubchem gtoplig chembl_ligand pubchem	small-molecule small-molecule	Agonist PAM	noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, dopamine, 5-hydroxytryptamine	small-molecule	Teng X, Chen S, Nie Y, Xiao P, Yu X, Shao Z, Zheng S	10.1038/S41467-022-30929-W	2022-06-15	56198
Gs	αs	Human	-	57	β1	Human	γ2	Human	Cryo-EM	7F24	-	4.2	DRD1	D₁	Dopamine	A (Rhodopsin)	Human	-	-	-	dopamine pubchem gtoplig chembl_ligand drugbank drug_central pubchem	small-molecule	Agonist	noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, dopamine, 5-hydroxytryptamine	small-molecule	Teng X, Chen S, Wang Q, Chen Z, Wang X, Huang N, Zheng S	10.1126/SCIADV.ABO4158	2022-06-15	56198
Gs	αs	Human	-	58	β1	Human	γ2	Human	Cryo-EM	7F0T	-	3.1	DRD1	D₁	Dopamine	A (Rhodopsin)	Human	-	Nanobody-35	-	dopamine pubchem gtoplig chembl_ligand drugbank drug_central pubchem	small-molecule	Agonist	noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, dopamine, 5-hydroxytryptamine	small-molecule	Teng X, Chen S, Wang Q, Chen Z, Wang X, Huang N, Zheng S	10.1126/SCIADV.ABO4158	2022-06-15	56198
Gs	αs	Human	-	60	β1	Human	γ2	Human	Cryo-EM	7F23	-	3.6	DRD1	D₁	Dopamine	A (Rhodopsin)	Human	-	Nanobody-35	-	dopamine pubchem gtoplig chembl_ligand drugbank drug_central pubchem	small-molecule	Agonist	noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, dopamine, 5-hydroxytryptamine	small-molecule	Teng X, Chen S, Wang Q, Chen Z, Wang X, Huang N, Zheng S	10.1126/SCIADV.ABO4158	2022-06-15	56198
Gs	αs	Human	-	60	β1	Human	γ2	Human	Cryo-EM	7F1Z	-	3.5	DRD1	D₁	Dopamine	A (Rhodopsin)	Human	-	-	-	dopamine pubchem gtoplig chembl_ligand drugbank drug_central pubchem	small-molecule	Agonist	noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, dopamine, 5-hydroxytryptamine	small-molecule	Teng X, Chen S, Wang Q, Chen Z, Wang X, Huang N, Zheng S	10.1126/SCIADV.ABO4158	2022-06-15	56198
Gs	αs	Human	-	58	β1	Human	γ2	Human	Cryo-EM	7X2D	7X2D_refined	3.3	DRD1	D₁	Dopamine	A (Rhodopsin)	Human	-	Nanobody-35	-	tavapadon pubchem gtoplig chembl_ligand drugbank pubchem	small-molecule	Agonist	noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, dopamine, 5-hydroxytryptamine	small-molecule	Teng X, Chen S, Nie Y, Xiao P, Yu X, Shao Z, Zheng S	10.1038/S41467-022-30929-W	2022-06-15	56198
Gq/11	αq	Human	-	58	β1	Human	γ2	Human	Cryo-EM	7SR8	-	3.3	OX2R	OX₂	Orexin	A (Rhodopsin)	Human	-	scFv16	-	methyl (2R,3S)-3-[(methanesulfonyl)amino]-2-({[(1s,4S)-4-phenylcyclohexyl]oxy}methyl)piperidine-1-carboxylate pubchem	small-molecule	Agonist	orexin-B, orexin-A	peptide	Yin J, Kang Y, McGrath AP, Chapman K, Sjodt M, Kimura E, Okabe A, Koike T, Miyanohana Y, Shimizu Y, Rallabandi R, Lian P, Bai X, Flinspach M, De Brabander JK, Rosenbaum DM	10.1038/S41467-022-30601-3	2022-06-08	56208
Gi/o	αi1	Human	-	64	β1	Rat	γ2	Bovine	Cryo-EM	7WIG	7WIG_refined	2.7	SSR2	SST2	Somatostatin	A (Rhodopsin)	Human	-	scFv16	-	~{N}-[(2~{R})-1-[[(1~{R},3~{S})-3-(aminomethyl)cyclohexyl]methylamino]-3-(1~{H}-indol-3-yl)-1-oxidanylidene-propan-2-yl]spiro[indene-1,4'-piperidine]-1'-carboxamide pubchem	small-molecule	Agonist	CST-17, SRIF-14, cortistatin-14, SRIF-28	peptide	Chen LN, Wang WW, Dong YJ, Shen DD, Guo J, Yu X, Qin J, Ji SY, Zhang H, Shen Q, He Q, Yang B, Zhang Y, Li Q, Mao C	10.1038/S41422-022-00669-Z	2022-06-01	56200
Gi/o	αi1	Human	-	64	β1	Rat	γ2	Human	Cryo-EM	7WIC	-	2.8	SSR2	SST2	Somatostatin	A (Rhodopsin)	Human	-	scFv16	-	SOMATOSTATIN chembl_ligand pubchem	protein	Agonist	CST-17, SRIF-14, cortistatin-14, SRIF-28	peptide	Chen LN, Wang WW, Dong YJ, Shen DD, Guo J, Yu X, Qin J, Ji SY, Zhang H, Shen Q, He Q, Yang B, Zhang Y, Li Q, Mao C	10.1038/S41422-022-00669-Z	2022-06-01	56200
Gi/o	αi1	Human	-	61	β1	Bovine	γ2	Bovine	Cryo-EM	7SQO	-	3.2	OX2R	OX₂	Orexin	A (Rhodopsin)	Human	-	scFv16	-	methyl (2R,3S)-3-[(methanesulfonyl)amino]-2-({[(1s,4S)-4-phenylcyclohexyl]oxy}methyl)piperidine-1-carboxylate pubchem	small-molecule	Agonist	orexin-B, orexin-A	peptide	Yin J, Kang Y, McGrath AP, Chapman K, Sjodt M, Kimura E, Okabe A, Koike T, Miyanohana Y, Shimizu Y, Rallabandi R, Lian P, Bai X, Flinspach M, De Brabander JK, Rosenbaum DM	10.1038/S41467-022-30601-3	2022-05-25	56200
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	7EUO	7EUO_refined	2.9	FPR1	FPR1	Formylpeptide	A (Rhodopsin)	Human	-	scFv16	-	Peptide Agonist fMLF	peptide	Agonist	fMet-Leu-Phe, cathepsin G, spinorphin, annexin I	peptide	Chen G, Wang X, Liao Q, Ge Y, Jiao H, Chen Q, Liu Y, Lyu W, Zhu L, van Zundert GCP, Robertson MJ, Skiniotis G, Du Y, Hu H, Ye RD	10.1038/S41467-022-32822-Y	2022-05-25	56200
Gi/o	αi1	Human	-	61	β1	Human	γ2	Human	Cryo-EM	7X9A	7X9A_refined	3.2	NPY1R	Y₁	Neuropeptide Y	A (Rhodopsin)	Human	-	-	-	neuropeptide Y pubchem gtoplig chembl_ligand gtoplig gtoplig pubchem pubchem pubchem	peptide	Agonist	peptide YY, pancreatic polypeptide, neuropeptide Y	peptide	Tang T, Tan Q, Han S, Diemar A, Lobner K, Wang H, Schuss C, Behr V, Morl K, Wang M, Chu X, Yi C, Keller M, Kofoed J, Reedtz-Runge S, Kaiser A, Beck-Sickinger AG, Zhao Q, Wu B	10.1126/SCIADV.ABM1232	2022-05-18	56200
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	7X9B	7X9B_refined	3.4	NPY2R	Y₂	Neuropeptide Y	A (Rhodopsin)	Human	-	-	-	neuropeptide Y pubchem gtoplig chembl_ligand gtoplig gtoplig pubchem pubchem pubchem	peptide	Agonist	PYY-(3-36), peptide YY, neuropeptide Y-(3-36), pancreatic polypeptide, neuropeptide Y	peptide	Tang T, Tan Q, Han S, Diemar A, Lobner K, Wang H, Schuss C, Behr V, Morl K, Wang M, Chu X, Yi C, Keller M, Kofoed J, Reedtz-Runge S, Kaiser A, Beck-Sickinger AG, Zhao Q, Wu B	10.1126/SCIADV.ABM1232	2022-05-18	56200
Gi/o	αi1	Human	-	61	β1	Human	γ2	Human	Cryo-EM	7X9C	7X9C_refined	3.0	NPY4R	Y₄	Neuropeptide Y	A (Rhodopsin)	Human	-	-	-	Pancreatic polypeptide pubchem	peptide	Agonist	PYY-(3-36), peptide YY, pancreatic polypeptide, neuropeptide Y	peptide	Tang T, Tan Q, Han S, Diemar A, Lobner K, Wang H, Schuss C, Behr V, Morl K, Wang M, Chu X, Yi C, Keller M, Kofoed J, Reedtz-Runge S, Kaiser A, Beck-Sickinger AG, Zhao Q, Wu B	10.1126/SCIADV.ABM1232	2022-05-18	56200
Gs	αs	Bovine	-	60	β1	Rat	γ2	Bovine	Cryo-EM	7VQX	-	2.7	VIPR2	VPAC₂	VIP and PACAP	B1 (Secretin)	Human	-	Nanobody-35	-	PACAP-27 pubchem gtoplig pubchem	peptide	Agonist	secretin, PACAP-27, VIP, PACAP-38, PHI, GHRH	peptide	Xu Y, Feng W, Zhou Q, Liang A, Li J, Dai A, Zhao F, Yan J, Chen CW, Li H, Zhao LH, Xia T, Jiang Y, Xu HE, Yang D, Wang MW	10.1038/S41467-022-30041-Z	2022-05-18	56215
Gs	αs	Bovine	-	60	β1	Rat	γ2	Bovine	Cryo-EM	7WBJ	-	3.4	VIPR2	VPAC₂	VIP and PACAP	B1 (Secretin)	Human	-	Nanobody-35	-	PACAP-27 pubchem gtoplig pubchem	peptide	Agonist	secretin, PACAP-27, VIP, PACAP-38, PHI, GHRH	peptide	Xu Y, Feng W, Zhou Q, Liang A, Li J, Dai A, Zhao F, Yan J, Chen CW, Li H, Zhao LH, Xia T, Jiang Y, Xu HE, Yang D, Wang MW	10.1038/S41467-022-30041-Z	2022-05-18	56215
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	7V69	-	3.4	ACM4	M₄	Acetylcholine (muscarinic)	A (Rhodopsin)	Human	-	scFv16	-	Apo (no ligand)	none	Apo (no ligand)	acetylcholine	small-molecule	-	-	2022-05-11	56200
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	7V6A	-	3.6	ACM4	M₄	Acetylcholine (muscarinic)	A (Rhodopsin)	Human	-	scFv16	-	methyl 4-[4-(3-methyl-2-oxidanylidene-benzimidazol-1-yl)piperidin-1-yl]piperidine-1-carboxylate pubchem	small-molecule	Allosteric agonist	acetylcholine	small-molecule	Wang J, Wu M, Chen Z, Wu L, Wang T, Cao D, Wang H, Liu S, Xu Y, Li F, Liu J, Chen N, Zhao S, Cheng J, Wang S, Hua T	10.1038/S41467-022-30595-Y	2022-05-11	56200
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	7V68	-	3.4	ACM4	M₄	Acetylcholine (muscarinic)	A (Rhodopsin)	Human	-	scFv16	-	iperoxo pubchem gtoplig chembl_ligand LY2119620 pubchem gtoplig chembl_ligand	small-molecule small-molecule	Agonist PAM	acetylcholine	small-molecule	Wang J, Wu M, Chen Z, Wu L, Wang T, Cao D, Wang H, Liu S, Xu Y, Li F, Liu J, Chen N, Zhao S, Cheng J, Wang S, Hua T	10.1038/S41467-022-30595-Y	2022-05-11	56200
Gs	αs	Bovine	-	60	β1	Rat	γ2	Bovine	Cryo-EM	7EQ1	-	3.3	AGRG5	ADGRG5	ADGRG	B2 (Adhesion)	Human	-	scFv16	-	Apo (no ligand)	none	Apo (no ligand)	-	-	Ping YQ, Xiao P, Yang F, Zhao RJ, Guo SC, Yan X, Wu X, Zhang C, Lu Y, Zhao F, Zhou F, Xi YT, Yin W, Liu FZ, He DF, Zhang DL, Zhu ZL, Jiang Y, Du L, Feng SQ, Schoneberg T, Liebscher I, Xu HE, Sun JP	10.1038/S41586-022-04619-Y	2022-05-11	56215
Gs	αs	Human	-	54	β1	Human	γ2	Human	Cryo-EM	7EPT	-	3.0	AGRD1	ADGRD1	ADGRD	B2 (Adhesion)	Human	-	Nanobody-35	-	Apo (no ligand)	none	Apo (no ligand)	-	-	Ping YQ, Xiao P, Yang F, Zhao RJ, Guo SC, Yan X, Wu X, Zhang C, Lu Y, Zhao F, Zhou F, Xi YT, Yin W, Liu FZ, He DF, Zhang DL, Zhu ZL, Jiang Y, Du L, Feng SQ, Schoneberg T, Liebscher I, Xu HE, Sun JP	10.1038/S41586-022-04619-Y	2022-05-11	56198
Gi/o	αi1	Human	-	61	β1	Human	γ2	Human	Cryo-EM	7U2L	-	3.2	OPRM	μ	Opioid	A (Rhodopsin)	Mouse	-	scFv16	-	N-(5-carbamimidamidopentyl)-N-[1-(2-phenylethyl)piperidin-4-yl]propanamide	small-molecule	Agonist	-	-	Faouzi A, Wang H, Zaidi SA, DiBerto JF, Che T, Qu Q, Robertson MJ, Madasu MK, El Daibani A, Varga BR, Zhang T, Ruiz C, Liu S, Xu J, Appourchaux K, Slocum ST, Eans SO, Cameron MD, Al-Hasani R, Pan YX, Roth BL, McLaughlin JP, Skiniotis G, Katritch V, Kobilka BK, Majumdar S	10.1038/S41586-022-05588-Y	2022-05-04	56200
Gs	αs	Human	-	59	β1	Rat	γ2	Bovine	Cryo-EM	7XJH	-	3.3	ADRB3	β₃	Adrenoceptors	A (Rhodopsin)	Dog	-	Nanobody-35	-	LEVISOPRENALINE chembl_ligand chembl_ligand pubchem	small-molecule	Agonist	-	-	Nagiri C, Kobayashi K, Tomita A, Kato M, Kobayashi K, Yamashita K, Nishizawa T, Inoue A, Shihoya W, Nureki O	10.1016/J.MOLCEL.2021.06.024	2022-05-04	56198
Gs	αs	Human	-	59	β1	Rat	γ2	Bovine	Cryo-EM	7XJI	-	3.9	ADRB3	β₃	Adrenoceptors	A (Rhodopsin)	Dog	-	Nanobody-35	-	3-[3-[2-[[(2~{S})-2-(3-chlorophenyl)-2-oxidanyl-ethyl]amino]ethylamino]phenyl]benzoic acid pubchem	small-molecule	Agonist	-	-	Nureki I, Kobayashi K, Tanaka T, Demura K, Inoue A, Shihoya W, Nureki O	10.1016/J.BBRC.2022.04.065	2022-05-04	56198
G12/13	α13	Human	Gi2-mini-G13 chimera	56	β1	Human	γ2	Human	Cryo-EM	7SF7	-	2.9	AGRL3	ADGRL3	ADGRL	B2 (Adhesion)	Human	-	-	-	Apo (no ligand)	none	Apo (no ligand)	-	-	Barros-Alvarez X, Nwokonko RM, Vizurraga A, Matzov D, He F, Papasergi-Scott MM, Robertson MJ, Panova O, Yardeni EH, Seven AB, Kwarcinski FE, Su H, Peroto MC, Meyerowitz JG, Shalev-Benami M, Tall GG, Skiniotis G	10.1038/S41586-022-04575-7	2022-04-27	56213
G12/13	α13	Human	Gi2-mini-G13 chimera	56	β1	Human	γ2	Human	Cryo-EM	7SF8	-	2.7	AGRG1	ADGRG1	ADGRG	B2 (Adhesion)	Human	-	-	-	Apo (no ligand)	none	Apo (no ligand)	-	-	Barros-Alvarez X, Nwokonko RM, Vizurraga A, Matzov D, He F, Papasergi-Scott MM, Robertson MJ, Panova O, Yardeni EH, Seven AB, Kwarcinski FE, Su H, Peroto MC, Meyerowitz JG, Shalev-Benami M, Tall GG, Skiniotis G	10.1038/S41586-022-04575-7	2022-04-27	56213
Gi/o	αi1	Human	Mini-Gi1	58	β1	Human	γ2	Human	Cryo-EM	7WU4	-	3.4	AGRF1	ADGRF1	ADGRF	B2 (Adhesion)	Human	-	-	-	Apo (no ligand)	none	Apo (no ligand)	-	-	Qu X, Qiu N, Wang M, Zhang B, Du J, Zhong Z, Xu W, Chu X, Ma L, Yi C, Han S, Shui W, Zhao Q, Wu B	10.1038/S41586-022-04580-W	2022-04-27	56200
Gi/o	αi1	Human	Mini-Gi1	58	β1	Human	γ2	Human	Cryo-EM	7WU5	-	3.0	AGRF1	ADGRF1	ADGRF	B2 (Adhesion)	Human	-	-	-	Apo (no ligand)	none	Apo (no ligand)	-	-	Qu X, Qiu N, Wang M, Zhang B, Du J, Zhong Z, Xu W, Chu X, Ma L, Yi C, Han S, Shui W, Zhao Q, Wu B	10.1038/S41586-022-04580-W	2022-04-27	56200
Gs	αs	Human	Mini-Gs	59	β1	Human	γ2	Human	Cryo-EM	7WUJ	-	3.3	AGRG4	ADGRG4	ADGRG	B2 (Adhesion)	Human	-	scFv16 Nanobody-35	-	Apo (no ligand)	none	Apo (no ligand)	-	-	Xiao P, Guo S, Wen X, He QT, Lin H, Huang SM, Gou L, Zhang C, Yang Z, Zhong YN, Yang CC, Li Y, Gong Z, Tao XN, Yang ZS, Lu Y, Li SL, He JY, Wang C, Zhang L, Kong L, Sun JP, Yu X	10.1038/S41586-022-04590-8	2022-04-27	56198
Gs	αs	Human	Mini-Gs	54	β1	Human	γ2	Human	Cryo-EM	7WU3	-	3.1	AGRF1	ADGRF1	ADGRF	B2 (Adhesion)	Human	-	Nanobody-35	-	Apo (no ligand)	none	Apo (no ligand)	-	-	Qu X, Qiu N, Wang M, Zhang B, Du J, Zhong Z, Xu W, Chu X, Ma L, Yi C, Han S, Shui W, Zhao Q, Wu B	10.1038/S41586-022-04580-W	2022-04-27	56198
Gs	αs	Human	-	55	β1	Human	γ2	Human	Cryo-EM	7WUQ	-	2.9	AGRG2	ADGRG2	ADGRG	B2 (Adhesion)	Mouse	-	Nanobody-35	-	Apo (no ligand)	none	Apo (no ligand)	-	-	Xiao P, Guo S, Wen X, He QT, Lin H, Huang SM, Gou L, Zhang C, Yang Z, Zhong YN, Yang CC, Li Y, Gong Z, Tao XN, Yang ZS, Lu Y, Li SL, He JY, Wang C, Zhang L, Kong L, Sun JP, Yu X	10.1038/S41586-022-04590-8	2022-04-27	56198
Gs	αs	Human	Mini-Gs	53	β1	Human	γ2	Human	Cryo-EM	7WU2	-	2.8	AGRD1	ADGRD1	ADGRD	B2 (Adhesion)	Human	-	Nanobody-35	-	Apo (no ligand)	none	Apo (no ligand)	-	-	Qu X, Qiu N, Wang M, Zhang B, Du J, Zhong Z, Xu W, Chu X, Ma L, Yi C, Han S, Shui W, Zhao Q, Wu B	10.1038/S41586-022-04580-W	2022-04-27	56198
Gs	αs	Human	Mini-Gs	58	β1	Human	γ2	Human	Cryo-EM	7WUI	-	3.1	AGRG2	ADGRG2	ADGRG	B2 (Adhesion)	Mouse	-	-	-	IP15	peptide	Agonist	-	-	Xiao P, Guo S, Wen X, He QT, Lin H, Huang SM, Gou L, Zhang C, Yang Z, Zhong YN, Yang CC, Li Y, Gong Z, Tao XN, Yang ZS, Lu Y, Li SL, He JY, Wang C, Zhang L, Kong L, Sun JP, Yu X	10.1038/S41586-022-04590-8	2022-04-27	56198
Gi/o	αi1	Human	-	64	β1	Rat	γ2	Bovine	Cryo-EM	7WQ3	7WQ3_refined	2.7	GALR1	GAL₁	Galanin	A (Rhodopsin)	Human	-	scFv16	-	galanin pubchem gtoplig chembl_ligand gtoplig pubchem pubchem pubchem pubchem	peptide	Agonist	galanin, galanin-like peptide	peptide	Duan J, Shen DD, Zhao T, Guo S, He X, Yin W, Xu P, Ji Y, Chen LN, Liu J, Zhang H, Liu Q, Shi Y, Cheng X, Jiang H, Eric Xu H, Zhang Y, Xie X, Jiang Y	10.1038/S41467-022-29072-3	2022-04-20	56200
Gi/o	αi1	Human	-	61	β1	Human	γ2	Human	Cryo-EM	7SCG	-	3.0	OPRM	μ	Opioid	A (Rhodopsin)	Mouse	-	scFv16	-	(2E)-N-[(2S)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl]-3-(naphthalen-1-yl)prop-2-enamide pubchem	small-molecule	Agonist	-	-	Wang H, Hetzer F, Huang W, Qu Q, Meyerowitz J, Kaindl J, Hubner H, Skiniotis G, Kobilka BK, Gmeiner P	10.1002/ANIE.202200269	2022-04-20	56200
Gi/o	αi1	Human	-	61	β1	Human	γ2	Human	Cryo-EM	7SBF	-	2.9	OPRM	μ	Opioid	A (Rhodopsin)	Mouse	BRIL	scFv16	-	N-[(2S)-2-(dimethylamino)-3-(4-hydroxyphenyl)propyl]-N'-[(2S)-1-(thiophen-3-yl)propan-2-yl]urea pubchem	small-molecule	Agonist	-	-	Wang H, Hetzer F, Huang W, Qu Q, Meyerowitz J, Kaindl J, Hubner H, Skiniotis G, Kobilka BK, Gmeiner P	10.1002/ANIE.202200269	2022-04-20	56200
Gq/11	αq	Human	-	59	β1	Human	γ2	Human	Cryo-EM	7W56	-	2.9	NMUR1	NMU1	Neuromedin U	A (Rhodopsin)	Human	-	scFv16	-	Neuromedin-S	peptide	Agonist	neuromedin U-23, neuromedin S-33, neuromedin U-25, neuromedin S-36	peptide	You C, Zhang Y, Xu P, Huang S, Yin W, Eric Xu H, Jiang Y	10.1038/S41467-022-29683-W	2022-04-20	56208
Gq/11	αq	Human	-	59	β1	Human	γ2	Human	Cryo-EM	7W57	-	3.2	NMUR2	NMU2	Neuromedin U	A (Rhodopsin)	Human	-	scFv16	-	Neuromedin-S	peptide	Agonist	neuromedin U-23, neuromedin S-33, neuromedin U-25, neuromedin S-36	peptide	You C, Zhang Y, Xu P, Huang S, Yin W, Eric Xu H, Jiang Y	10.1038/S41467-022-29683-W	2022-04-20	56208
Gq/11	αq	Human	-	60	β1	Human	γ2	Human	Cryo-EM	7W55	-	2.8	NMUR2	NMU2	Neuromedin U	A (Rhodopsin)	Human	-	scFv16	-	Neuromedin U-25 (human) pubchem	peptide	Agonist	neuromedin U-23, neuromedin S-33, neuromedin U-25, neuromedin S-36	peptide	You C, Zhang Y, Xu P, Huang S, Yin W, Eric Xu H, Jiang Y	10.1038/S41467-022-29683-W	2022-04-20	56208
Gq/11	αq	Human	-	60	β1	Rat	γ2	Bovine	Cryo-EM	7WQ4	7WQ4_refined	2.6	GALR2	GAL₂	Galanin	A (Rhodopsin)	Human	-	Nanobody-35	-	galanin pubchem gtoplig chembl_ligand gtoplig pubchem pubchem pubchem pubchem	peptide	Agonist	galanin, spexin-1, galanin-like peptide	peptide	Duan J, Shen DD, Zhao T, Guo S, He X, Yin W, Xu P, Ji Y, Chen LN, Liu J, Zhang H, Liu Q, Shi Y, Cheng X, Jiang H, Eric Xu H, Zhang Y, Xie X, Jiang Y	10.1038/S41467-022-29072-3	2022-04-20	56208
Gq/11	αq	Human	-	54	β1	Human	γ2	Human	Cryo-EM	7W53	-	3.2	NMUR1	NMU1	Neuromedin U	A (Rhodopsin)	Human	-	scFv16	-	Neuromedin U-25 (human) pubchem	peptide	Agonist	neuromedin U-23, neuromedin S-33, neuromedin U-25, neuromedin S-36	peptide	You C, Zhang Y, Xu P, Huang S, Yin W, Eric Xu H, Jiang Y	10.1038/S41467-022-29683-W	2022-04-20	56208
Gi/o	αi2	Human	-	63	β1	Human	γ2	Human	Cryo-EM	7WVY	7WVY_refined	3.0	FPR2	FPR2/ALX	Formylpeptide	A (Rhodopsin)	Human	BRIL	-	-	Amyloid beta-Peptide (1-42) pubchem	peptide	Agonist	PrP_106-126, aspirin triggered lipoxin A4, annexin I, LL-37, aspirin-triggered resolvin D1, serum amyloid A, resolvin D1, humanin, LXA₄	peptide	Zhu Y, Lin X, Zong X, Han S, Wang M, Su Y, Ma L, Chu X, Yi C, Zhao Q, Wu B	10.1038/S41467-022-29361-X	2022-04-13	56201
Gi/o	αo	Human	-	61	β1	Human	γ2	Human	Cryo-EM	7EJ0	-	3.2	ADA2A	α_2A	Adrenoceptors	A (Rhodopsin)	Human	-	scFv16	-	(-)-noradrenaline pubchem gtoplig chembl_ligand drugbank drug_central pubchem	small-molecule	Agonist	(-)-adrenaline, (-)-noradrenaline	small-molecule	Xu J, Cao S, Hubner H, Weikert D, Chen G, Lu Q, Yuan D, Gmeiner P, Liu Z, Du Y	10.1126/SCIADV.ABJ5347	2022-04-13	56206
Gi/o	αo	Human	-	59	β1	Human	γ2	Human	Cryo-EM	7EJA	-	3.6	ADA2A	α_2A	Adrenoceptors	A (Rhodopsin)	Human	-	scFv16	-	dexmedetomidine pubchem gtoplig chembl_ligand drugbank drug_central pubchem	small-molecule	Agonist	(-)-adrenaline, (-)-noradrenaline	small-molecule	Xu J, Cao S, Hubner H, Weikert D, Chen G, Lu Q, Yuan D, Gmeiner P, Liu Z, Du Y	10.1126/SCIADV.ABJ5347	2022-04-13	56206
Gi/o	αi2	Human	-	63	β1	Human	γ2	Human	Cryo-EM	7WVW	-	3.1	FPR2	FPR2/ALX	Formylpeptide	A (Rhodopsin)	Human	BRIL	-	-	FME-TYR-PHE-ILE-ASN-ILE-LEU-THE-LEU	peptide	Agonist	PrP_106-126, aspirin triggered lipoxin A4, annexin I, LL-37, aspirin-triggered resolvin D1, serum amyloid A, resolvin D1, humanin, LXA₄	peptide	Zhu Y, Lin X, Zong X, Han S, Wang M, Su Y, Ma L, Chu X, Yi C, Zhao Q, Wu B	10.1038/S41467-022-29361-X	2022-04-13	56201
Gi/o	αi2	Human	-	61	β1	Human	γ2	Human	Cryo-EM	7WVX	-	2.8	FPR2	FPR2/ALX	Formylpeptide	A (Rhodopsin)	Human	BRIL	-	-	humanin pubchem gtoplig chembl_ligand pubchem	peptide	Agonist	PrP_106-126, aspirin triggered lipoxin A4, annexin I, LL-37, aspirin-triggered resolvin D1, serum amyloid A, resolvin D1, humanin, LXA₄	peptide	Zhu Y, Lin X, Zong X, Han S, Wang M, Su Y, Ma L, Chu X, Yi C, Zhao Q, Wu B	10.1038/S41467-022-29361-X	2022-04-13	56201
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	7WVU	7WVU_refined	3.3	FPR1	FPR1	Formylpeptide	A (Rhodopsin)	Human	-	-	-	FME-LEU-PHE	peptide	Agonist	fMet-Leu-Phe, cathepsin G, spinorphin, annexin I	peptide	Zhu Y, Lin X, Zong X, Han S, Wang M, Su Y, Ma L, Chu X, Yi C, Zhao Q, Wu B	10.1038/S41467-022-29361-X	2022-04-13	56200
Gi/o	αi1	Human	-	61	β1	Human	γ2	Human	Cryo-EM	7EJX	-	2.4	GPR88	GPR88	A orphans	A (Rhodopsin)	Human	-	scFv16	-	compound 2 [PMID: 24793972] pubchem gtoplig chembl_ligand	small-molecule	Allosteric agonist	-	-	Chen G, Xu J, Inoue A, Schmidt MF, Bai C, Lu Q, Gmeiner P, Liu Z, Du Y	10.1038/S41467-022-30081-5	2022-04-13	56200
Gi/o	αi2	Human	-	63	β1	Human	γ2	Human	Cryo-EM	7WVV	7WVV_refined	2.9	FPR2	FPR2/ALX	Formylpeptide	A (Rhodopsin)	Human	BRIL	-	-	synthetic peptide	peptide	Agonist	PrP_106-126, aspirin triggered lipoxin A4, annexin I, LL-37, aspirin-triggered resolvin D1, serum amyloid A, resolvin D1, humanin, LXA₄	peptide	Zhu Y, Lin X, Zong X, Han S, Wang M, Su Y, Ma L, Chu X, Yi C, Zhao Q, Wu B	10.1038/S41467-022-29361-X	2022-04-13	56201
Gi/o	αi1	Human	-	64	β1	Human	γ2	Human	Cryo-EM	7TUZ	7TUZ_refined	3.1	GP183	GPR183	A orphans	A (Rhodopsin)	Human	-	scFv16	-	(2S,4aS,4bS,7R,8S,8aS,9R,10aR)-7-[(2R,3R)-7-hydroxy-3,7-dimethyloctan-2-yl]-4a,7,8-trimethyltetradecahydrophenanthrene-2,9-diol pubchem	small-molecule	Agonist	7β, 25-dihydroxycholesterol, 27-hydroxycholesterol, 7β, 27-dihydroxycholesterol, 7α,27-dihydroxycholesterol, 7β-hydroxycholesterol, 25-hydroxycholesterol, 7α,25-dihydroxycholesterol, 7α-hydroxycholesterol	small-molecule	Chen H, Huang W, Li X	10.1016/J.STR.2022.04.006	2022-04-13	56200
Gi/o	αo	Human	-	61	β1	Human	γ2	Human	Cryo-EM	7EJ8	-	3.0	ADA2A	α_2A	Adrenoceptors	A (Rhodopsin)	Human	-	scFv16	-	brimonidine (UK14304) pubchem gtoplig chembl_ligand drugbank drug_central gtoplig pubchem	small-molecule	Agonist	(-)-adrenaline, (-)-noradrenaline	small-molecule	Xu J, Cao S, Hubner H, Weikert D, Chen G, Lu Q, Yuan D, Gmeiner P, Liu Z, Du Y	10.1126/SCIADV.ABJ5347	2022-04-13	56206
Gi/o	αo	Human	-	61	β1	Human	γ2	Human	Cryo-EM	7EJK	-	3.4	ADA2A	α_2A	Adrenoceptors	A (Rhodopsin)	Human	-	scFv16	-	oxymetazoline pubchem gtoplig chembl_ligand drugbank drug_central pubchem	small-molecule	Agonist	(-)-adrenaline, (-)-noradrenaline	small-molecule	Xu J, Cao S, Hubner H, Weikert D, Chen G, Lu Q, Yuan D, Gmeiner P, Liu Z, Du Y	10.1126/SCIADV.ABJ5347	2022-04-13	56206
Gs	αs	Human	-	56	β1	Human	γ2	Human	Cryo-EM	7RBT	7RBT_refined	3.1	GIPR	GIP	Glucagon	B1 (Secretin)	Human	-	scFv16 Nanobody-35	-	tirzepatide pubchem gtoplig 2-fluoro-4-[(1R)-6-methoxy-1-methyl-2-{(1S)-1-[4-(propan-2-yl)phenyl]ethyl}-1,2,3,4-tetrahydroisoquinolin-5-yl]-6-[(2-methylpropyl)amino]phenol pubchem	peptide small-molecule	Agonist PAM	gastric inhibitory polypeptide	peptide	Sun B, Willard FS, Feng D, Alsina-Fernandez J, Chen Q, Vieth M, Ho JD, Showalter AD, Stutsman C, Ding L, Suter TM, Dunbar JD, Carpenter JW, Mohammed FA, Aihara E, Brown RA, Bueno AB, Emmerson PJ, Moyers JS, Kobilka TS, Coghlan MP, Kobilka BK, Sloop KW	10.1073/PNAS.2116506119	2022-04-13	56198
Gs	αs	Human	Engineered G alpha	56	β1	Human	γ2	Human	Cryo-EM	7RA3	-	3.2	GIPR	GIP	Glucagon	B1 (Secretin)	Human	-	scFv16 Nanobody-35	-	gastric inhibitory polypeptide (human) - Incretin pubchem	peptide	Agonist	gastric inhibitory polypeptide	peptide	Sun B, Willard FS, Feng D, Alsina-Fernandez J, Chen Q, Vieth M, Ho JD, Showalter AD, Stutsman C, Ding L, Suter TM, Dunbar JD, Carpenter JW, Mohammed FA, Aihara E, Brown RA, Bueno AB, Emmerson PJ, Moyers JS, Kobilka TS, Coghlan MP, Kobilka BK, Sloop KW	10.1073/PNAS.2116506119	2022-04-13	56198
Gs	αs	Human	-	56	β1	Human	γ2	Human	Cryo-EM	7RG9	7RG9_refined	3.2	GLP1R	GLP-1	Glucagon	B1 (Secretin)	Human	-	scFv16 Nanobody-35	-	Apo (no ligand)	none	Apo (no ligand)	glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37)	peptide	Sun B, Willard FS, Feng D, Alsina-Fernandez J, Chen Q, Vieth M, Ho JD, Showalter AD, Stutsman C, Ding L, Suter TM, Dunbar JD, Carpenter JW, Mohammed FA, Aihara E, Brown RA, Bueno AB, Emmerson PJ, Moyers JS, Kobilka TS, Coghlan MP, Kobilka BK, Sloop KW	10.1073/PNAS.2116506119	2022-04-13	56198
Gs	αs	Human	Engineered G alpha	55	β1	Human	γ2	Human	Cryo-EM	7RGP	-	2.9	GLP1R	GLP-1	Glucagon	B1 (Secretin)	Human	-	scFv16 Nanobody-35	-	tirzepatide pubchem gtoplig	peptide	Agonist	glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37)	peptide	Sun B, Willard FS, Feng D, Alsina-Fernandez J, Chen Q, Vieth M, Ho JD, Showalter AD, Stutsman C, Ding L, Suter TM, Dunbar JD, Carpenter JW, Mohammed FA, Aihara E, Brown RA, Bueno AB, Emmerson PJ, Moyers JS, Kobilka TS, Coghlan MP, Kobilka BK, Sloop KW	10.1073/PNAS.2116506119	2022-04-13	56198
G12/13	α13	Human	-	60	β1	Human	γ2	Human	Cryo-EM	7T6B	7T6B_refined	3.2	S1PR2	S1P₂	Lysophospholipid (S1P)	A (Rhodopsin)	Human	-	scFv16	-	sphingosine 1-phosphate pubchem gtoplig chembl_ligand pubchem	small-molecule	Agonist	dihydrosphingosine 1-phosphate, sphingosylphosphorylcholine, sphingosine 1-phosphate	small-molecule	Chen H, Chen K, Huang W, Staudt LM, Cyster JG, Li X	10.1126/SCIADV.ABN0067	2022-04-06	56213
Gs	αs	Human	-	60	β1	Rat	γ2	Bovine	Cryo-EM	7V9L	-	2.6	GHRHR	GHRH	Glucagon	B1 (Secretin)	Human	-	Nanobody-35	-	Apo (no ligand)	none	Apo (no ligand)	GHRH	peptide	Cong Z, Zhou F, Zhang C, Zou X, Zhang H, Wang Y, Zhou Q, Cai X, Liu Q, Li J, Shao L, Mao C, Wang X, Wu J, Xia T, Zhao LH, Jiang H, Zhang Y, Xu HE, Cheng X, Yang D, Wang MW	10.1073/PNAS.2106606118	2022-04-06	56198
Gs	αs	Human	-	53	β1	Rat	γ2	Bovine	Cryo-EM	7VBH	7VBH_refined	3.0	GLP1R	GLP-1	Glucagon	B1 (Secretin)	Human	-	Nanobody-35	-	Peptide 20	peptide	Agonist	glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37)	peptide	Zhao F, Zhou Q, Cong Z, Hang K, Zou X, Zhang C, Chen Y, Dai A, Liang A, Ming Q, Wang M, Chen LN, Xu P, Chang R, Feng W, Xia T, Zhang Y, Wu B, Yang D, Zhao L, Xu HE, Wang MW	10.1038/S41467-022-28683-0	2022-04-06	56198
Gi/o	αi1	Human	-	61	β1	Rat	γ2	Bovine	Cryo-EM	7T6V	7T6V_refined	3.1	FPR2	FPR2/ALX	Formylpeptide	A (Rhodopsin)	Human	-	scFv16	-	synthetic peptide	peptide	Agonist	PrP_106-126, aspirin triggered lipoxin A4, annexin I, LL-37, aspirin-triggered resolvin D1, serum amyloid A, resolvin D1, humanin, LXA₄	peptide	Zhuang Y, Wang L, Guo J, Sun D, Wang Y, Liu W, Xu HE, Zhang C	10.1038/S41467-022-28586-0	2022-03-30	56200
Gi/o	αi1	Human	-	61	β1	Rat	γ2	Bovine	Cryo-EM	7T6S	7T6S_refined	3.0	FPR2	FPR2/ALX	Formylpeptide	A (Rhodopsin)	Human	-	scFv16	-	N-(4-chlorophenyl)-N'-[1-methyl-3-oxo-2-phenyl-5-(propan-2-yl)-2,3-dihydro-1H-pyrazol-4-yl]urea pubchem	small-molecule	Agonist	PrP_106-126, aspirin triggered lipoxin A4, annexin I, LL-37, aspirin-triggered resolvin D1, serum amyloid A, resolvin D1, humanin, LXA₄	peptide	-	-	2022-03-30	56200
Gi/o	αi1	Human	-	62	β1	Rat	γ2	Bovine	Cryo-EM	7T6U	-	2.9	FPR2	FPR2/ALX	Formylpeptide	A (Rhodopsin)	Human	-	-	-	synthetic peptide	peptide	Agonist	PrP_106-126, aspirin triggered lipoxin A4, annexin I, LL-37, aspirin-triggered resolvin D1, serum amyloid A, resolvin D1, humanin, LXA₄	peptide	Zhuang Y, Wang L, Guo J, Sun D, Wang Y, Liu W, Xu HE, Zhang C	10.1038/S41467-022-28586-0	2022-03-30	56200
Gi/o	αi1	Human	-	61	β1	Rat	γ2	Bovine	Cryo-EM	7T6T	7T6T_refined	3.2	FPR1	FPR1	Formylpeptide	A (Rhodopsin)	Human	-	-	-	synthetic peptide	peptide	Agonist	fMet-Leu-Phe, cathepsin G, spinorphin, annexin I	peptide	Zhuang Y, Wang L, Guo J, Sun D, Wang Y, Liu W, Xu HE, Zhang C	10.1038/S41467-022-28586-0	2022-03-30	56200
Gs	αs	Human	-	59	β1	Human	γ2	Human	Cryo-EM	7TYX	-	2.6	CALCR	CT	Calcitonin	B1 (Secretin)	Human	-	Nanobody-35	-	Amylin rat pubchem	peptide	Agonist	adrenomedullin, calcitonin, β-CGRP, adrenomedullin 2/intermedin, α-CGRP, amylin	peptide	Cao J, Belousoff MJ, Liang YL, Johnson RM, Josephs TM, Fletcher MM, Christopoulos A, Hay DL, Danev R, Wootten D, Sexton PM	10.1126/SCIENCE.ABM9609	2022-03-30	56198
Gs	αs	Human	-	58	β1	Human	γ2	Human	Cryo-EM	7TYN	-	2.6	CALCR	CT	Calcitonin	B1 (Secretin)	Human	-	Nanobody-35	-	calcitonin (salmon synthetic) pubchem chembl_ligand pubchem pubchem	small-molecule	Agonist	adrenomedullin, calcitonin, β-CGRP, adrenomedullin 2/intermedin, α-CGRP, amylin	peptide	Cao J, Belousoff MJ, Liang YL, Johnson RM, Josephs TM, Fletcher MM, Christopoulos A, Hay DL, Danev R, Wootten D, Sexton PM	10.1126/SCIENCE.ABM9609	2022-03-30	56198
Gs	αs	Human	-	58	β1	Human	γ2	Human	Cryo-EM	7TYI	-	3.3	CALCR	CT	Calcitonin	B1 (Secretin)	Human	-	Nanobody-35	-	Amylin rat pubchem	peptide	Agonist	adrenomedullin, calcitonin, β-CGRP, adrenomedullin 2/intermedin, α-CGRP, amylin	peptide	Cao J, Belousoff MJ, Liang YL, Johnson RM, Josephs TM, Fletcher MM, Christopoulos A, Hay DL, Danev R, Wootten D, Sexton PM	10.1126/SCIENCE.ABM9609	2022-03-30	56198
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	7VL8	7VL8_refined	2.9	CCR1	CCR1	Chemokine	A (Rhodopsin)	Human	-	scFv16	-	Apo (no ligand)	none	Apo (no ligand)	CCL13, CCL23, CCL8, CCL15, CCL7, CCL4, CCL14, CCL5, CCL3, CCL16	peptide	Shao Z, Shen Q, Yao B, Mao C, Chen LN, Zhang H, Shen DD, Zhang C, Li W, Du X, Li F, Ma H, Chen ZH, Xu HE, Ying S, Zhang Y, Shen H	10.1038/S41589-021-00918-Z	2022-03-23	56200
Gi/o	αi1	Human	-	64	β1	Human	γ2	Human	Cryo-EM	7VLA	7VLA_refined	2.7	CCR1	CCR1	Chemokine	A (Rhodopsin)	Human	-	scFv16	-	CCL15(27-92)	peptide	Agonist	CCL13, CCL23, CCL8, CCL15, CCL7, CCL4, CCL14, CCL5, CCL3, CCL16	peptide	Shao Z, Shen Q, Yao B, Mao C, Chen LN, Zhang H, Shen DD, Zhang C, Li W, Du X, Li F, Ma H, Chen ZH, Xu HE, Ying S, Zhang Y, Shen H	10.1038/S41589-021-00918-Z	2022-03-23	56200
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	7VL9	-	2.6	CCR1	CCR1	Chemokine	A (Rhodopsin)	Human	-	scFv16	-	CCL15(26-92)	peptide	Agonist	CCL13, CCL23, CCL8, CCL15, CCL7, CCL4, CCL14, CCL5, CCL3, CCL16	peptide	Shao Z, Shen Q, Yao B, Mao C, Chen LN, Zhang H, Shen DD, Zhang C, Li W, Du X, Li F, Ma H, Chen ZH, Xu HE, Ying S, Zhang Y, Shen H	10.1038/S41589-021-00918-Z	2022-03-23	56200
Gs	αs	Human	-	58	β1	Human	γ2	Human	Cryo-EM	7TYF	-	2.2	CALCR	CT	Calcitonin	B1 (Secretin)	Human	-	Nanobody-35 RAMP1	-	amylin peptide	peptide	Agonist	adrenomedullin, calcitonin, β-CGRP, adrenomedullin 2/intermedin, α-CGRP, amylin	peptide	Cao J, Belousoff MJ, Liang YL, Johnson RM, Josephs TM, Fletcher MM, Christopoulos A, Hay DL, Danev R, Wootten D, Sexton PM	10.1126/SCIENCE.ABM9609	2022-03-23	56198
Gs	αs	Human	-	59	β1	Human	γ2	Human	Cryo-EM	7TZF	-	2.4	CALCR	CT	Calcitonin	B1 (Secretin)	Human	-	Nanobody-35 RAMP3	-	amylin peptide	peptide	Agonist	adrenomedullin, calcitonin, β-CGRP, adrenomedullin 2/intermedin, α-CGRP, amylin	peptide	Cao J, Belousoff MJ, Liang YL, Johnson RM, Josephs TM, Fletcher MM, Christopoulos A, Hay DL, Danev R, Wootten D, Sexton PM	10.1126/SCIENCE.ABM9609	2022-03-23	56198
Gs	αs	Human	-	58	β1	Human	γ2	Human	Cryo-EM	7TYH	-	3.3	CALCR	CT	Calcitonin	B1 (Secretin)	Human	-	Nanobody-35	-	Calcitonin human pubchem	peptide	Agonist	adrenomedullin, calcitonin, β-CGRP, adrenomedullin 2/intermedin, α-CGRP, amylin	peptide	Cao J, Belousoff MJ, Liang YL, Johnson RM, Josephs TM, Fletcher MM, Christopoulos A, Hay DL, Danev R, Wootten D, Sexton PM	10.1126/SCIENCE.ABM9609	2022-03-23	56198
Gs	αs	Human	-	58	β1	Human	γ2	Human	Cryo-EM	7TYO	-	2.7	CALCR	CT	Calcitonin	B1 (Secretin)	Human	-	Nanobody-35	-	Calcitonin human pubchem	peptide	Agonist	adrenomedullin, calcitonin, β-CGRP, adrenomedullin 2/intermedin, α-CGRP, amylin	peptide	Cao J, Belousoff MJ, Liang YL, Johnson RM, Josephs TM, Fletcher MM, Christopoulos A, Hay DL, Danev R, Wootten D, Sexton PM	10.1126/SCIENCE.ABM9609	2022-03-23	56198
Gs	αs	Human	-	58	β1	Human	γ2	Human	Cryo-EM	7TYY	-	3.0	CALCR	CT	Calcitonin	B1 (Secretin)	Human	-	Nanobody-35	-	calcitonin (salmon synthetic) pubchem chembl_ligand pubchem pubchem	small-molecule	Agonist	adrenomedullin, calcitonin, β-CGRP, adrenomedullin 2/intermedin, α-CGRP, amylin	peptide	Cao J, Belousoff MJ, Liang YL, Johnson RM, Josephs TM, Fletcher MM, Christopoulos A, Hay DL, Danev R, Wootten D, Sexton PM	10.1126/SCIENCE.ABM9609	2022-03-23	56198
Gs	αs	Human	-	58	β1	Human	γ2	Human	Cryo-EM	7TYL	-	3.3	CALCR	CT	Calcitonin	B1 (Secretin)	Human	-	Nanobody-35	-	Amylin rat pubchem	peptide	Agonist	adrenomedullin, calcitonin, β-CGRP, adrenomedullin 2/intermedin, α-CGRP, amylin	peptide	Cao J, Belousoff MJ, Liang YL, Johnson RM, Josephs TM, Fletcher MM, Christopoulos A, Hay DL, Danev R, Wootten D, Sexton PM	10.1126/SCIENCE.ABM9609	2022-03-23	56198
Gs	αs	Human	-	58	β1	Human	γ2	Human	Cryo-EM	7TYW	-	3.0	CALCR	CT	Calcitonin	B1 (Secretin)	Human	-	Nanobody-35	-	calcitonin (salmon synthetic) pubchem chembl_ligand pubchem pubchem	small-molecule	Agonist	adrenomedullin, calcitonin, β-CGRP, adrenomedullin 2/intermedin, α-CGRP, amylin	peptide	Cao J, Belousoff MJ, Liang YL, Johnson RM, Josephs TM, Fletcher MM, Christopoulos A, Hay DL, Danev R, Wootten D, Sexton PM	10.1126/SCIENCE.ABM9609	2022-03-23	56198
Gi/o	αi1	Human	-	64	β1	Human	γ2	Human	Cryo-EM	7VKT	7VKT_refined	2.9	LT4R1	BLT₁	Leukotriene	A (Rhodopsin)	Human	-	scFv16	-	LTB₄ pubchem gtoplig chembl_ligand drugbank	small-molecule	Agonist	12R-HETE, 20-hydroxy-LTB₄, LTB₄	small-molecule	Wang N, He X, Zhao J, Jiang H, Cheng X, Xia Y, Eric Xu H, He Y	10.1038/S41467-022-28820-9	2022-03-09	56200
Gi/o	αi3	Human	-	62	β1	Human	γ2	Human	Cryo-EM	7T11	7T11_refined	2.7	SSR2	SST2	Somatostatin	A (Rhodopsin)	Human	-	scFv16	-	Octreotide	peptide	Agonist	CST-17, SRIF-14, cortistatin-14, SRIF-28	peptide	Robertson MJ, Meyerowitz JG, Panova O, Borrelli K, Skiniotis G	10.1038/S41594-022-00727-5	2022-03-09	56202
Gi/o	αi3	Human	-	62	β1	Human	γ2	Human	Cryo-EM	7T10	-	2.5	SSR2	SST2	Somatostatin	A (Rhodopsin)	Human	-	scFv16	-	SOMATOSTATIN chembl_ligand pubchem	protein	Agonist	CST-17, SRIF-14, cortistatin-14, SRIF-28	peptide	Robertson MJ, Meyerowitz JG, Panova O, Borrelli K, Skiniotis G	10.1038/S41594-022-00727-5	2022-03-09	56202
Gq/11	αq	Human	Gamma subunit fused to alpha subunit	55	β1	Human	-	-	Cryo-EM	7RYC	-	2.9	OXYR	OT	Vasopressin and oxytocin	A (Rhodopsin)	Human	-	scFv16	-	oxytocin pubchem gtoplig chembl_ligand drugbank drug_central gtoplig pubchem	peptide	Agonist	oxytocin, vasopressin	peptide	Meyerowitz JG, Robertson MJ, Barros-Alvarez X, Panova O, Nwokonko RM, Gao Y, Skiniotis G	10.1038/S41594-022-00728-4	2022-03-09	56208
Gi/o	αi1	Human	-	62	β1	Rat	γ2	Bovine	Cryo-EM	7VGZ	7VGZ_refined	3.3	MTR1A	MT₁	Melatonin	A (Rhodopsin)	Human	-	scFv16	-	ramelteon pubchem gtoplig chembl_ligand drugbank drug_central pubchem	small-molecule	Agonist	melatonin	small-molecule	Wang Q, Lu Q, Guo Q, Teng M, Gong Q, Li X, Du Y, Liu Z, Tao Y	10.1038/S41467-022-28111-3	2022-03-02	56200
Gi/o	αi1	Human	-	61	β1	Rat	γ2	Human	Cryo-EM	7VH0	7VH0_refined	3.5	MTR1B	MT₂	Melatonin	A (Rhodopsin)	Human	-	scFv16	-	ramelteon pubchem gtoplig chembl_ligand drugbank drug_central pubchem	small-molecule	Agonist	melatonin	small-molecule	Wang Q, Lu Q, Guo Q, Teng M, Gong Q, Li X, Du Y, Liu Z, Tao Y	10.1038/S41467-022-28111-3	2022-03-02	56200
Gi/o	αi1	Human	-	62	β1	Rat	γ2	Bovine	Cryo-EM	7VGY	-	3.1	MTR1A	MT₁	Melatonin	A (Rhodopsin)	Human	-	scFv16	-	2-iodo-melatonin pubchem gtoplig chembl_ligand drugbank	small-molecule	Agonist	melatonin	small-molecule	Wang Q, Lu Q, Guo Q, Teng M, Gong Q, Li X, Du Y, Liu Z, Tao Y	10.1038/S41467-022-28111-3	2022-03-02	56200
Gs	αs	Human	-	53	β1	Rat	γ2	Bovine	Cryo-EM	7V35	7V35_refined	3.4	GLR	glucagon	Glucagon	B1 (Secretin)	Human	-	Nanobody-35	-	Peptide-20	peptide	Agonist	glucagon	peptide	Zhao F, Zhou Q, Cong Z, Hang K, Zou X, Zhang C, Chen Y, Dai A, Liang A, Ming Q, Wang M, Chen LN, Xu P, Chang R, Feng W, Xia T, Zhang Y, Wu B, Yang D, Zhao L, Xu HE, Wang MW	10.1038/S41467-022-28683-0	2022-03-02	56198
Gs	αs	Bovine	-	60	β1	Rat	γ2	Bovine	Cryo-EM	7FIY	-	3.4	GIPR	GIP	Glucagon	B1 (Secretin)	Human	-	Nanobody-35	-	tirzepatide pubchem gtoplig	peptide	Agonist	gastric inhibitory polypeptide	peptide	Zhao F, Zhou Q, Cong Z, Hang K, Zou X, Zhang C, Chen Y, Dai A, Liang A, Ming Q, Wang M, Chen LN, Xu P, Chang R, Feng W, Xia T, Zhang Y, Wu B, Yang D, Zhao L, Xu HE, Wang MW	10.1038/S41467-022-28683-0	2022-03-02	56215
Gs	αs	Human	Mini-Gs	60	β1	Rat	γ2	Bovine	Cryo-EM	7VAB	7VAB_refined	3.2	GIPR	GIP	Glucagon	B1 (Secretin)	Human	-	Nanobody-35	-	tirzepatide pubchem gtoplig	peptide	Agonist	gastric inhibitory polypeptide	peptide	Zhao F, Zhou Q, Cong Z, Hang K, Zou X, Zhang C, Chen Y, Dai A, Liang A, Ming Q, Wang M, Chen LN, Xu P, Chang R, Feng W, Xia T, Zhang Y, Wu B, Yang D, Zhao L, Xu HE, Wang MW	10.1038/S41467-022-28683-0	2022-03-02	56198
Gs	αs	Human	Mini-Gs	58	β1	Rat	γ2	Bovine	Cryo-EM	7VBI	-	3.0	GLP1R	GLP-1	Glucagon	B1 (Secretin)	Human	-	-	-	tirzepatide pubchem gtoplig	peptide	Agonist	glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37)	peptide	Zhao F, Zhou Q, Cong Z, Hang K, Zou X, Zhang C, Chen Y, Dai A, Liang A, Ming Q, Wang M, Chen LN, Xu P, Chang R, Feng W, Xia T, Zhang Y, Wu B, Yang D, Zhao L, Xu HE, Wang MW	10.1038/S41467-022-28683-0	2022-03-02	56198
Gs	αs	Bovine	-	57	β1	Rat	γ2	Bovine	Cryo-EM	7FIM	-	3.4	GLP1R	GLP-1	Glucagon	B1 (Secretin)	Human	-	Nanobody-35	-	tirzepatide pubchem gtoplig	peptide	Agonist	glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37)	peptide	Zhao F, Zhou Q, Cong Z, Hang K, Zou X, Zhang C, Chen Y, Dai A, Liang A, Ming Q, Wang M, Chen LN, Xu P, Chang R, Feng W, Xia T, Zhang Y, Wu B, Yang D, Zhao L, Xu HE, Wang MW	10.1038/S41467-022-28683-0	2022-03-02	56215
Gs	αs2	Human	-	88	-	-	-	-	X-ray	7E5E	-	2.0	-	-	-	-	-	-	-	GD20	-	-	-	-	-	Dai SA, Hu Q, Gao R, Blythe EE, Touhara KK, Peacock H, Zhang Z, von Zastrow M, Suga H, Shokat KM	36170854	2022-03-02	56198
Gi/o	αi1	Human	-	63	β1	Human	γ2	Human	Cryo-EM	7VGX	7VGX_refined	3.2	NPY1R	Y₁	Neuropeptide Y	A (Rhodopsin)	Human	-	scFv16	-	neuropeptide Y pubchem gtoplig chembl_ligand gtoplig gtoplig pubchem pubchem pubchem	peptide	Agonist	peptide YY, pancreatic polypeptide, neuropeptide Y	peptide	Park C, Kim J, Ko SB, Choi YK, Jeong H, Woo H, Kang H, Bang I, Kim SA, Yoon TY, Seok C, Im W, Choi HJ	10.1038/S41467-022-28510-6	2022-02-23	56200
Gs	αs	Bovine	-	59	β1	Rat	γ2	Bovine	Cryo-EM	7FIN	-	3.1	GIPR	GIP	Glucagon	B1 (Secretin)	Human	-	Nanobody-35	-	Peptide-20	peptide	Agonist	gastric inhibitory polypeptide	peptide	Zhao F, Zhou Q, Cong Z, Hang K, Zou X, Zhang C, Chen Y, Dai A, Liang A, Ming Q, Wang M, Chen LN, Xu P, Chang R, Feng W, Xia T, Zhang Y, Wu B, Yang D, Zhao L, Xu HE, Wang MW	10.1038/S41467-022-28683-0	2022-02-23	56215
Gi/o	αi1	Mouse	-	63	β1	Bovine	γ2	Bovine	Cryo-EM	7TD4	-	2.6	S1PR1	S1P₁	Lysophospholipid (S1P)	A (Rhodopsin)	Human	-	-	-	siponimod pubchem gtoplig chembl_ligand drug_central drugbank pubchem	small-molecule	Agonist	dihydrosphingosine 1-phosphate, sphingosylphosphorylcholine, sphingosine 1-phosphate	small-molecule	Liu S, Paknejad N, Zhu L, Kihara Y, Ray M, Chun J, Liu W, Hite RK, Huang XY	10.1038/S41467-022-28417-2	2022-02-09	56242
Gi/o	αi1	Mouse	-	62	β1	Bovine	γ2	Bovine	Cryo-EM	7TD1	-	3.1	LPAR1	LPA₁	Lysophospholipid (LPA)	A (Rhodopsin)	Human	-	-	-	lysophosphatidic acid pubchem	small-molecule	Agonist	1-O-Oleoyl-D-glycerol 3-phosphoric acid	small-molecule	Liu S, Paknejad N, Zhu L, Kihara Y, Ray M, Chun J, Liu W, Hite RK, Huang XY	10.1038/S41467-022-28417-2	2022-02-09	56242
Gi/o	αi1	Mouse	-	62	β1	Bovine	γ2	Bovine	Cryo-EM	7TD2	-	3.1	LPAR1	LPA₁	Lysophospholipid (LPA)	A (Rhodopsin)	Human	-	-	-	lysophosphatidic acid pubchem	small-molecule	Agonist	1-O-Oleoyl-D-glycerol 3-phosphoric acid	small-molecule	Liu S, Paknejad N, Zhu L, Kihara Y, Ray M, Chun J, Liu W, Hite RK, Huang XY	10.1038/S41467-022-28417-2	2022-02-09	56242
Gi/o	αi1	Mouse	-	63	β1	Bovine	γ2	Bovine	Cryo-EM	7TD3	-	3.0	S1PR1	S1P₁	Lysophospholipid (S1P)	A (Rhodopsin)	Human	-	-	-	sphingosine 1-phosphate pubchem gtoplig chembl_ligand pubchem	small-molecule	Agonist	dihydrosphingosine 1-phosphate, sphingosylphosphorylcholine, sphingosine 1-phosphate	small-molecule	Liu S, Paknejad N, Zhu L, Kihara Y, Ray M, Chun J, Liu W, Hite RK, Huang XY	10.1038/S41467-022-28417-2	2022-02-09	56242
Gi/o	αi1	Mouse	-	62	β1	Bovine	γ2	Bovine	Cryo-EM	7TD0	-	2.8	LPAR1	LPA₁	Lysophospholipid (LPA)	A (Rhodopsin)	Human	-	-	-	lysophosphatidic acid pubchem	small-molecule	Agonist	1-O-Oleoyl-D-glycerol 3-phosphoric acid	small-molecule	Liu S, Paknejad N, Zhu L, Kihara Y, Ray M, Chun J, Liu W, Hite RK, Huang XY	10.1038/S41467-022-28417-2	2022-02-09	56242
Gi/o	αi1	Human	-	61	β1	Human	γ2	Human	Cryo-EM	7RKN	-	3.6	US28	US28	Unclassified	A (Rhodopsin)	strain AD169	-	scFv16	-	Fractalkine pubchem	peptide	Agonist	-	-	Tsutsumi N, Maeda S, Qu Q, Vogele M, Jude KM, Suomivuori CM, Panova O, Waghray D, Kato HE, Velasco A, Dror RO, Skiniotis G, Kobilka BK, Garcia KC	10.1126/SCIADV.ABL5442	2022-01-26	56200
Gi/o	αi1	Human	-	61	β1	Human	γ2	Human	Cryo-EM	7RKM	-	3.5	US28	US28	Unclassified	A (Rhodopsin)	strain AD169	-	scFv16	-	Fractalkine pubchem	peptide	Agonist	-	-	Tsutsumi N, Maeda S, Qu Q, Vogele M, Jude KM, Suomivuori CM, Panova O, Waghray D, Kato HE, Velasco A, Dror RO, Skiniotis G, Kobilka BK, Garcia KC	10.1126/SCIADV.ABL5442	2022-01-26	56200
Gi/o	αi1	Human	-	100	β1	Human	γ2	Human	Cryo-EM	7RKX	-	3.1	-	-	-	-	-	-	Antibody fragment scFv16	G-protein coupled receptor homolog US27	-	-	-	-	-	-	-	2022-01-26	56200
Gi/o	αi1	Human	-	100	β1	Human	γ2	Human	Cryo-EM	7RKY	-	3.8	-	-	-	-	-	-	Antibody fragment scFv16	G-protein coupled receptor homolog US27	-	-	-	-	-	-	-	2022-01-26	56200
Gq/11	α11	Human	-	97	β1	Human	γ2	Human	Cryo-EM	7RKF	-	4.0	US28	US28	Unclassified	A (Rhodopsin)	strain AD169	-	scFv16	-	Fractalkine pubchem	peptide	Agonist	-	-	Tsutsumi N, Maeda S, Qu Q, Vogele M, Jude KM, Suomivuori CM, Panova O, Waghray D, Kato HE, Velasco A, Dror RO, Skiniotis G, Kobilka BK, Garcia KC	10.1126/SCIADV.ABL5442	2022-01-26	56209
Gs	αs2	Bovine	-	100	-	-	-	-	Cryo-EM	7PDF	-	3.8	-	-	-	-	-	-	-	Adenylate cyclase 9	-	-	-	-	-	Qi C, Lavriha P, Mehta V, Khanppnavar B, Mohammed I, Li Y, Lazaratos M, Schaefer JV, Dreier B, Pluckthun A, Bondar AN, Dessauer CW, Korkhov VM	35210418	2022-01-26	56215
Gi/o	αo	Human	-	60	β1	Human	γ2	Human	Cryo-EM	7W2Z	7W2Z_refined	2.8	GHSR	ghrelin	Ghrelin	A (Rhodopsin)	Human	-	scFv16	-	Ghrelin pubchem	peptide	Agonist	[des-Gln¹⁴]ghrelin, ghrelin	peptide	Qin J, Cai Y, Xu Z, Ming Q, Ji SY, Wu C, Zhang H, Mao C, Shen DD, Hirata K, Ma Y, Yan W, Zhang Y, Shao Z	10.1038/S41467-022-27975-9	2022-01-19	56206
Gs	αs2	Bovine	-	100	-	-	-	-	Cryo-EM	7PDE	-	4.5	-	-	-	-	-	-	-	Adenylate cyclase 9	-	-	-	-	-	Qi C, Lavriha P, Mehta V, Khanppnavar B, Mohammed I, Li Y, Lazaratos M, Schaefer JV, Dreier B, Pluckthun A, Bondar AN, Dessauer CW, Korkhov VM	35210418	2022-01-19	56215
Gs	αs	Human	-	59	β1	Human	γ2	Human	Cryo-EM	7LLL	-	3.7	GLP1R	GLP-1	Glucagon	B1 (Secretin)	Human	-	Nanobody-35	-	exendin-4 pubchem gtoplig pubchem	peptide	Agonist	glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37)	peptide	Deganutti G, Liang YL, Zhang X, Khoshouei M, Clydesdale L, Belousoff MJ, Venugopal H, Truong TT, Glukhova A, Keller AN, Gregory KJ, Leach K, Christopoulos A, Danev R, Reynolds CA, Zhao P, Sexton PM, Wootten D	10.1038/S41467-021-27760-0	2022-01-12	56198
Gs	αs	Human	-	50	β1	Human	γ2	Human	Cryo-EM	7LLY	7LLY_refined	3.3	GLP1R	GLP-1	Glucagon	B1 (Secretin)	Human	-	Nanobody-35	-	Pro-glucagon pubchem	peptide	Agonist	glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37)	peptide	Deganutti G, Liang YL, Zhang X, Khoshouei M, Clydesdale L, Belousoff MJ, Venugopal H, Truong TT, Glukhova A, Keller AN, Gregory KJ, Leach K, Christopoulos A, Danev R, Reynolds CA, Zhao P, Sexton PM, Wootten D	10.1038/S41467-021-27760-0	2022-01-12	56198
Gi/o	αi1	Human	-	43	β1	Human	γ2	Human	Cryo-EM	7EO4	7EO4_refined	2.9	S1PR1	S1P₁	Lysophospholipid (S1P)	A (Rhodopsin)	Human	-	scFv16	-	siponimod pubchem gtoplig chembl_ligand drug_central drugbank pubchem	small-molecule	Agonist	dihydrosphingosine 1-phosphate, sphingosylphosphorylcholine, sphingosine 1-phosphate	small-molecule	Xu Z, Ikuta T, Kawakami K, Kise R, Qian Y, Xia R, Sun MX, Zhang A, Guo C, Cai XH, Huang Z, Inoue A, He Y	10.1038/S41589-021-00930-3	2022-01-05	56200
Gi/o	αi1	Human	-	40	β1	Human	γ2	Human	Cryo-EM	7WF7	7WF7_refined	3.4	S1PR1	S1P₁	Lysophospholipid (S1P)	A (Rhodopsin)	Human	-	scFv16	-	sphingosine 1-phosphate pubchem gtoplig chembl_ligand pubchem	small-molecule	Agonist	dihydrosphingosine 1-phosphate, sphingosylphosphorylcholine, sphingosine 1-phosphate	small-molecule	Xu Z, Ikuta T, Kawakami K, Kise R, Qian Y, Xia R, Sun MX, Zhang A, Guo C, Cai XH, Huang Z, Inoue A, He Y	10.1038/S41589-021-00930-3	2022-01-05	56200
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	7EO2	7EO2_refined	2.9	S1PR1	S1P₁	Lysophospholipid (S1P)	A (Rhodopsin)	Human	-	scFv16	-	(S)-FTY720-phosphate pubchem gtoplig chembl_ligand	small-molecule	Agonist	dihydrosphingosine 1-phosphate, sphingosylphosphorylcholine, sphingosine 1-phosphate	small-molecule	Xu Z, Ikuta T, Kawakami K, Kise R, Qian Y, Xia R, Sun MX, Zhang A, Guo C, Cai XH, Huang Z, Inoue A, He Y	10.1038/S41589-021-00930-3	2022-01-05	56200
Gq/11	αq	Human	-	63	β1	Human	γ2	Human	Cryo-EM	7F6I	7F6I_refined	2.8	BKRB2	B₂	Bradykinin	A (Rhodopsin)	Human	-	-	-	kallidin pubchem gtoplig	peptide	Agonist	T-kinin, kallidin, Lys-[Hyp³]-bradykinin, bradykinin, [des-Arg¹⁰]kallidin, [Hyp³]bradykinin, [des-Arg⁹]bradykinin	peptide	Shen J, Zhang D, Fu Y, Chen A, Yang X, Zhang H	10.1038/S41467-022-28399-1	2022-01-05	56208
Gq/11	αq	Human	-	63	β1	Human	γ2	Human	Cryo-EM	7F6H	7F6H_refined	2.9	BKRB2	B₂	Bradykinin	A (Rhodopsin)	Human	-	-	-	bradykinin pubchem gtoplig chembl_ligand drugbank gtoplig	peptide	Agonist	T-kinin, kallidin, Lys-[Hyp³]-bradykinin, bradykinin, [des-Arg¹⁰]kallidin, [Hyp³]bradykinin, [des-Arg⁹]bradykinin	peptide	Shen J, Zhang D, Fu Y, Chen A, Yang X, Zhang H	10.1038/S41467-022-28399-1	2022-01-05	56208
Gs	αs	Human	-	59	β1	Human	γ2	Human	Cryo-EM	7S1M	7S1M_refined	2.4	GLP1R	GLP-1	Glucagon	B1 (Secretin)	Human	-	Nanobody-35	-	exendin-4 pubchem gtoplig pubchem	peptide	Agonist	glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37)	peptide	Cary BP, Deganutti G, Zhao P, Truong TT, Piper SJ, Liu X, Belousoff MJ, Danev R, Sexton PM, Wootten D, Gellman SH	10.1038/S41589-021-00945-W	2022-01-05	56198
Gs	αs	Human	-	59	β1	Human	γ2	Human	Cryo-EM	7S3I	-	2.5	GLP1R	GLP-1	Glucagon	B1 (Secretin)	Human	-	Nanobody-35	-	exendin-4 pubchem gtoplig pubchem	peptide	Agonist	glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37)	peptide	Cary BP, Deganutti G, Zhao P, Truong TT, Piper SJ, Liu X, Belousoff MJ, Danev R, Sexton PM, Wootten D, Gellman SH	10.1038/S41589-021-00945-W	2022-01-05	56198
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	7VUG	7VUG_refined	3.2	GP139	GPR139	A orphans	A (Rhodopsin)	Human	-	scFv16	Xylanase	JNJ-63533054 pubchem gtoplig chembl_ligand	small-molecule	Agonist	L-tryptophan, L-phenylalanine	small-molecule	Zhou Y, Daver H, Trapkov B, Wu L, Wu M, Harpsoe K, Gentry PR, Liu K, Larionova M, Liu J, Chen N, Brauner-Osborne H, Gloriam DE, Hua T, Liu ZJ	10.1038/S41422-021-00591-W	2021-12-29	56200
Gs	αs	Human	-	61	β1	Human	γ2	Human	Cryo-EM	7VUH	7VUH_refined	3.2	GP139	GPR139	A orphans	A (Rhodopsin)	Human	-	Nanobody-35	Xylanase	JNJ-63533054 pubchem gtoplig chembl_ligand	small-molecule	Agonist	L-tryptophan, L-phenylalanine	small-molecule	-	-	2021-12-29	56198
Gs	αs	Human	-	59	β1	Human	γ2	Human	Cryo-EM	7VUI	7VUI_refined	3.3	GP139	GPR139	A orphans	A (Rhodopsin)	Human	-	Nanobody-35	Xylanase	JNJ-63533054 pubchem gtoplig chembl_ligand	small-molecule	Agonist	L-tryptophan, L-phenylalanine	small-molecule	Zhou Y, Daver H, Trapkov B, Wu L, Wu M, Harpsoe K, Gentry PR, Liu K, Larionova M, Liu J, Chen N, Brauner-Osborne H, Gloriam DE, Hua T, Liu ZJ	10.1038/S41422-021-00591-W	2021-12-29	56198
Gs	αs	Human	-	59	β1	Human	γ2	Human	Cryo-EM	7VUJ	7VUJ_refined	3.8	GP139	GPR139	A orphans	A (Rhodopsin)	Human	-	Nanobody-35	Xylanase	JNJ-63533054 pubchem gtoplig chembl_ligand	small-molecule	Agonist	L-tryptophan, L-phenylalanine	small-molecule	Zhou Y, Daver H, Trapkov B, Wu L, Wu M, Harpsoe K, Gentry PR, Liu K, Larionova M, Liu J, Chen N, Brauner-Osborne H, Gloriam DE, Hua T, Liu ZJ	10.1038/S41422-021-00591-W	2021-12-29	56198
Gi/o	αi1	Human	-	61	β1	Human	γ2	Human	Cryo-EM	7NA8	-	2.7	GHSR	ghrelin	Ghrelin	A (Rhodopsin)	Human	-	Antibody fragment	-	ibutamoren pubchem gtoplig chembl_ligand	small-molecule	Agonist	[des-Gln¹⁴]ghrelin, ghrelin	peptide	Liu H, Sun D, Myasnikov A, Damian M, Baneres JL, Sun J, Zhang C	10.1038/S41467-021-26735-5	2021-12-15	56200
Gi/o	αi1	Human	-	61	β1	Human	γ2	Human	Cryo-EM	7NA7	7NA7_refined	2.7	GHSR	ghrelin	Ghrelin	A (Rhodopsin)	Human	-	Antibody fragment	-	Ghrelin-27	peptide	Agonist	[des-Gln¹⁴]ghrelin, ghrelin	peptide	Liu H, Sun D, Myasnikov A, Damian M, Baneres JL, Sun J, Zhang C	10.1038/S41467-021-26735-5	2021-12-15	56200
Gq/11	αq	Human	Gq-Gs-Gi1 chimera	59	β1	Human	γ2	Human	Cryo-EM	7P00	-	2.7	NK1R	NK₁	Tachykinin	A (Rhodopsin)	Human	-	scFv16	-	substance P pubchem gtoplig chembl_ligand gtoplig gtoplig	peptide	Agonist	neurokinin A, neuropeptide K, hemokinin 1, neurokinin B, neuropeptide-γ, substance P	peptide	Thom C, Ehrenmann J, Vacca S, Waltenspuhl Y, Schoppe J, Medalia O, Pluckthun A	10.1126/SCIADV.ABK2872	2021-12-15	56208
Gs	αs	Human	Gs-Gi1 chimera	57	β1	Human	γ2	Human	Cryo-EM	7P02	-	2.9	NK1R	NK₁	Tachykinin	A (Rhodopsin)	Human	-	scFv16	-	substance P pubchem gtoplig chembl_ligand gtoplig gtoplig	peptide	Agonist	neurokinin A, neuropeptide K, hemokinin 1, neurokinin B, neuropeptide-γ, substance P	peptide	Thom C, Ehrenmann J, Vacca S, Waltenspuhl Y, Schoppe J, Medalia O, Pluckthun A	10.1126/SCIADV.ABK2872	2021-12-15	56198
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	7VUZ	7VUZ_refined	2.9	MRGX2	MRGPRX2	A orphans	A (Rhodopsin)	Human	-	scFv16	-	PAMP-12 pubchem	peptide	Agonist	PAMP-20	peptide	Yang F, Guo L, Li Y, Wang G, Wang J, Zhang C, Fang GX, Chen X, Liu L, Yan X, Liu Q, Qu C, Xu Y, Xiao P, Zhu Z, Li Z, Zhou J, Yu X, Gao N, Sun JP	10.1038/S41586-021-04077-Y	2021-12-01	56200
Gi/o	αi1	Human	-	64	β1	Human	γ2	Human	Cryo-EM	7VUY	-	2.8	MRGX2	MRGPRX2	A orphans	A (Rhodopsin)	Human	-	scFv16	-	PAMP-12 pubchem	peptide	Agonist	PAMP-20	peptide	Yang F, Guo L, Li Y, Wang G, Wang J, Zhang C, Fang GX, Chen X, Liu L, Yan X, Liu Q, Qu C, Xu Y, Xiao P, Zhu Z, Li Z, Zhou J, Yu X, Gao N, Sun JP	10.1038/S41586-021-04077-Y	2021-12-01	56200
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	7VV3	-	3.0	MRGX2	MRGPRX2	A orphans	A (Rhodopsin)	Human	-	scFv16	-	Cortistatin 14 pubchem	peptide	Agonist	PAMP-20	peptide	Yang F, Guo L, Li Y, Wang G, Wang J, Zhang C, Fang GX, Chen X, Liu L, Yan X, Liu Q, Qu C, Xu Y, Xiao P, Zhu Z, Li Z, Zhou J, Yu X, Gao N, Sun JP	10.1038/S41586-021-04077-Y	2021-12-01	56200
Gi/o	αi1	Human	-	61	β1	Human	γ2	Human	Cryo-EM	7VDL	-	3.2	MRGX2	MRGPRX2	A orphans	A (Rhodopsin)	Human	-	scFv16	-	Cortistatin 14 pubchem	peptide	Agonist	PAMP-20	peptide	Yang F, Guo L, Li Y, Wang G, Wang J, Zhang C, Fang GX, Chen X, Liu L, Yan X, Liu Q, Qu C, Xu Y, Xiao P, Zhu Z, Li Z, Zhou J, Yu X, Gao N, Sun JP	10.1038/S41586-021-04077-Y	2021-12-01	56200
Gi/o	αi1	Human	-	64	β1	Human	γ2	Human	Cryo-EM	7VV5	7VV5_refined	2.8	MRGX2	MRGPRX2	A orphans	A (Rhodopsin)	Human	-	scFv16	-	compound 48/80 pubchem gtoplig	small-molecule	Agonist	PAMP-20	peptide	Yang F, Guo L, Li Y, Wang G, Wang J, Zhang C, Fang GX, Chen X, Liu L, Yan X, Liu Q, Qu C, Xu Y, Xiao P, Zhu Z, Li Z, Zhou J, Yu X, Gao N, Sun JP	10.1038/S41586-021-04077-Y	2021-12-01	56200
Gi/o	αi1	Human	-	61	β1	Human	γ2	Human	Cryo-EM	7VDM	7VDM_refined	3.0	MRGX2	MRGPRX2	A orphans	A (Rhodopsin)	Human	-	scFv16	-	substance P pubchem gtoplig chembl_ligand gtoplig gtoplig	peptide	Agonist	PAMP-20	peptide	Yang F, Guo L, Li Y, Wang G, Wang J, Zhang C, Fang GX, Chen X, Liu L, Yan X, Liu Q, Qu C, Xu Y, Xiao P, Zhu Z, Li Z, Zhou J, Yu X, Gao N, Sun JP	10.1038/S41586-021-04077-Y	2021-12-01	56200
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	7VDH	-	2.9	MRGX2	MRGPRX2	A orphans	A (Rhodopsin)	Human	-	scFv16	-	compound 48/80 pubchem gtoplig	small-molecule	Agonist	PAMP-20	peptide	Yang F, Guo L, Li Y, Wang G, Wang J, Zhang C, Fang GX, Chen X, Liu L, Yan X, Liu Q, Qu C, Xu Y, Xiao P, Zhu Z, Li Z, Zhou J, Yu X, Gao N, Sun JP	10.1038/S41586-021-04077-Y	2021-12-01	56200
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	7S8O	-	2.6	MRGX2	MRGPRX2	A orphans	A (Rhodopsin)	Human	BRIL	scFv16	-	(R)-ZINC-3573 pubchem gtoplig chembl_ligand	small-molecule	Agonist	PAMP-20	peptide	Cao C, Kang HJ, Singh I, Chen H, Zhang C, Ye W, Hayes BW, Liu J, Gumpper RH, Bender BJ, Slocum ST, Krumm BE, Lansu K, McCorvy JD, Kroeze WK, English JG, DiBerto JF, Olsen RHJ, Huang XP, Zhang S, Liu Y, Kim K, Karpiak J, Jan LY, Abraham SN, Jin J, Shoichet BK, Fay JF, Roth BL	10.1038/S41586-021-04126-6	2021-11-17	56200
Gi/o	αi1	Human	-	63	β1	Bovine	γ2	Bovine	Cryo-EM	7S0F	-	3.0	ADRB1	β₁	Adrenoceptors	A (Rhodopsin)	Wild turkey	-	-	-	LEVISOPRENALINE chembl_ligand chembl_ligand pubchem	small-molecule	Agonist	-	-	Alegre KO, Paknejad N, Su M, Lou JS, Huang J, Jordan KD, Eng ET, Meyerson JR, Hite RK, Huang XY	10.1038/S41594-021-00679-2	2021-11-17	56200
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	7S8M	-	2.5	MRGX2	MRGPRX2	A orphans	A (Rhodopsin)	Human	BRIL	scFv16	-	Cortistatin 14 pubchem	peptide	Agonist	PAMP-20	peptide	Cao C, Kang HJ, Singh I, Chen H, Zhang C, Ye W, Hayes BW, Liu J, Gumpper RH, Bender BJ, Slocum ST, Krumm BE, Lansu K, McCorvy JD, Kroeze WK, English JG, DiBerto JF, Olsen RHJ, Huang XP, Zhang S, Liu Y, Kim K, Karpiak J, Jan LY, Abraham SN, Jin J, Shoichet BK, Fay JF, Roth BL	10.1038/S41586-021-04126-6	2021-11-17	56200
Gq/11	αq	Human	Gq-Gs chimera	57	β1	Human	γ2	Human	Cryo-EM	7S8N	7S8N_refined	2.9	MRGX2	MRGPRX2	A orphans	A (Rhodopsin)	Human	-	scFv16	-	(R)-ZINC-3573 pubchem gtoplig chembl_ligand	small-molecule	Agonist	PAMP-20	peptide	Cao C, Kang HJ, Singh I, Chen H, Zhang C, Ye W, Hayes BW, Liu J, Gumpper RH, Bender BJ, Slocum ST, Krumm BE, Lansu K, McCorvy JD, Kroeze WK, English JG, DiBerto JF, Olsen RHJ, Huang XP, Zhang S, Liu Y, Kim K, Karpiak J, Jan LY, Abraham SN, Jin J, Shoichet BK, Fay JF, Roth BL	10.1038/S41586-021-04126-6	2021-11-17	56208
Gq/11	αq	Human	Gq-Gs chimera	57	β1	Human	γ2	Human	Cryo-EM	7S8P	7S8P_refined	2.6	MRGX4	MRGPRX4	A orphans	A (Rhodopsin)	Human	BRIL	scFv16	-	N-[(1r,3R,5S,7R)-3,5-dimethyltricyclo[3.3.1.1~3,7~]decane-1-carbonyl]-D-phenylalanine pubchem	small-molecule	Agonist	-	-	Cao C, Kang HJ, Singh I, Chen H, Zhang C, Ye W, Hayes BW, Liu J, Gumpper RH, Bender BJ, Slocum ST, Krumm BE, Lansu K, McCorvy JD, Kroeze WK, English JG, DiBerto JF, Olsen RHJ, Huang XP, Zhang S, Liu Y, Kim K, Karpiak J, Jan LY, Abraham SN, Jin J, Shoichet BK, Fay JF, Roth BL	10.1038/S41586-021-04126-6	2021-11-17	56208
Gq/11	αq	Human	Gq-Gs chimera	57	β1	Human	γ2	Human	Cryo-EM	7S8L	-	2.5	MRGX2	MRGPRX2	A orphans	A (Rhodopsin)	Human	-	scFv16	-	Cortistatin 14 pubchem	peptide	Agonist	PAMP-20	peptide	Cao C, Kang HJ, Singh I, Chen H, Zhang C, Ye W, Hayes BW, Liu J, Gumpper RH, Bender BJ, Slocum ST, Krumm BE, Lansu K, McCorvy JD, Kroeze WK, English JG, DiBerto JF, Olsen RHJ, Huang XP, Zhang S, Liu Y, Kim K, Karpiak J, Jan LY, Abraham SN, Jin J, Shoichet BK, Fay JF, Roth BL	10.1038/S41586-021-04126-6	2021-11-17	56208
Gq/11	αq	Mouse	-	91	-	-	-	-	X-ray	7SQ2	-	2.6	-	-	-	-	-	-	-	1-phosphatidylinositol 4 5-bisphosphate phosphodiesterase beta-3	-	-	-	-	-	Waldo GL, Ricks TK, Hicks SN, Cheever ML, Kawano T, Tsuboi K, Wang X, Montell C, Kozasa T, Sondek J, Harden TK	20966218	2021-11-17	56422
Gs	αs	Bovine	Gi1-Gs chimera	56	β1	Bovine	γ2	Bovine	Cryo-EM	7S0G	-	3.9	ADRB1	β₁	Adrenoceptors	A (Rhodopsin)	Wild turkey	-	-	-	LEVISOPRENALINE chembl_ligand chembl_ligand pubchem	small-molecule	Agonist	-	-	Alegre KO, Paknejad N, Su M, Lou JS, Huang J, Jordan KD, Eng ET, Meyerson JR, Hite RK, Huang XY	10.1038/S41594-021-00679-2	2021-11-17	56215
Gs	αs	Human	-	48	β1	Rat	γ2	Bovine	Cryo-EM	7PIU	-	2.6	MC4R	MC₄	Melanocortin	A (Rhodopsin)	Human	-	Nanobody-35	-	setmelanotide pubchem gtoplig drug_central chembl_ligand drugbank pubchem	peptide	Agonist	γ-MSH, α-MSH, β-MSH, ACTH, agouti-related protein	peptide	Heyder NA, Kleinau G, Speck D, Schmidt A, Paisdzior S, Szczepek M, Bauer B, Koch A, Gallandi M, Kwiatkowski D, Burger J, Mielke T, Beck-Sickinger AG, Hildebrand PW, Spahn CMT, Hilger D, Schacherl M, Biebermann H, Hilal T, Kuhnen P, Kobilka BK, Scheerer P	10.1038/S41422-021-00569-8	2021-11-17	56198
Gs	αs	Human	-	46	β1	Rat	γ2	Mouse	Cryo-EM	7PIV	7PIV_refined	2.9	MC4R	MC₄	Melanocortin	A (Rhodopsin)	Human	-	Nanobody-35	-	afamelanotide pubchem gtoplig chembl_ligand drugbank pubchem pubchem pubchem pubchem pubchem	peptide	Agonist	γ-MSH, α-MSH, β-MSH, ACTH, agouti-related protein	peptide	Heyder NA, Kleinau G, Speck D, Schmidt A, Paisdzior S, Szczepek M, Bauer B, Koch A, Gallandi M, Kwiatkowski D, Burger J, Mielke T, Beck-Sickinger AG, Hildebrand PW, Spahn CMT, Hilger D, Schacherl M, Biebermann H, Hilal T, Kuhnen P, Kobilka BK, Scheerer P	10.1038/S41422-021-00569-8	2021-11-17	56198
Gq/11	αq	Human	Gs-Gq chimera	52	β1	Human	γ2	Human	Cryo-EM	7RMG	-	3.0	NK1R	NK₁	Tachykinin	A (Rhodopsin)	Human	-	Nanobody-35	-	substance P pubchem gtoplig chembl_ligand gtoplig gtoplig	peptide	Agonist	neurokinin A, neuropeptide K, hemokinin 1, neurokinin B, neuropeptide-γ, substance P	peptide	Harris JA, Faust B, Gondin AB, Damgen MA, Suomivuori CM, Veldhuis NA, Cheng Y, Dror RO, Thal DM, Manglik A	10.1038/S41589-021-00890-8	2021-11-03	56208
Gs	αs	Human	-	58	β1	Human	γ2	Human	Cryo-EM	7F58	7F58_refined	3.1	MC4R	MC₄	Melanocortin	A (Rhodopsin)	Human	-	Nanobody-35	-	THIQ pubchem gtoplig chembl_ligand	small-molecule	Agonist	γ-MSH, α-MSH, β-MSH, ACTH, agouti-related protein	peptide	Zhang H, Chen LN, Yang D, Mao C, Shen Q, Feng W, Shen DD, Dai A, Xie S, Zhou Y, Qin J, Sun JP, Scharf DH, Hou T, Zhou T, Wang MW, Zhang Y	10.1038/S41422-021-00552-3	2021-11-03	56198
Gs	αs	Human	-	58	β1	Human	γ2	Human	Cryo-EM	7F54	-	3.0	MC4R	MC₄	Melanocortin	A (Rhodopsin)	Human	-	Nanobody-35	-	afamelanotide pubchem gtoplig chembl_ligand drugbank pubchem pubchem pubchem pubchem pubchem	peptide	Agonist	γ-MSH, α-MSH, β-MSH, ACTH, agouti-related protein	peptide	-	-	2021-11-03	56198
Gs	αs	Human	Gs-Gq chimera	49	β1	Human	γ2	Human	Cryo-EM	7RMI	-	3.2	NK1R	NK₁	Tachykinin	A (Rhodopsin)	Human	-	Nanobody-35	-	substance P pubchem gtoplig chembl_ligand gtoplig gtoplig	peptide	Agonist	neurokinin A, neuropeptide K, hemokinin 1, neurokinin B, neuropeptide-γ, substance P	peptide	Harris JA, Faust B, Gondin AB, Damgen MA, Suomivuori CM, Veldhuis NA, Cheng Y, Dror RO, Thal DM, Manglik A	10.1038/S41589-021-00890-8	2021-11-03	56198
Gs	αs	Human	-	58	β1	Human	γ2	Human	Cryo-EM	7F53	-	3.0	MC4R	MC₄	Melanocortin	A (Rhodopsin)	Human	-	Nanobody-35	-	α-MSH pubchem gtoplig	peptide	Agonist	γ-MSH, α-MSH, β-MSH, ACTH, agouti-related protein	peptide	-	-	2021-11-03	56198
Gs	αs	Human	-	58	β1	Human	γ2	Human	Cryo-EM	7F55	-	3.1	MC4R	MC₄	Melanocortin	A (Rhodopsin)	Human	-	Nanobody-35	-	bremelanotide pubchem gtoplig chembl_ligand drugbank drug_central pubchem	peptide	Agonist	γ-MSH, α-MSH, β-MSH, ACTH, agouti-related protein	peptide	-	-	2021-11-03	56198
Gs	αs	Human	-	55	β1	Human	γ2	Human	Cryo-EM	7RMH	7RMH_refined	3.1	NK1R	NK₁	Tachykinin	A (Rhodopsin)	Human	-	Nanobody-35	-	substance P pubchem gtoplig chembl_ligand gtoplig gtoplig	peptide	Agonist	neurokinin A, neuropeptide K, hemokinin 1, neurokinin B, neuropeptide-γ, substance P	peptide	Harris JA, Faust B, Gondin AB, Damgen MA, Suomivuori CM, Veldhuis NA, Cheng Y, Dror RO, Thal DM, Manglik A	10.1038/S41589-021-00890-8	2021-11-03	56198
Gs	αs	Human	-	57	β1	Rat	γ2	Bovine	Cryo-EM	7V9M	7V9M_refined	3.3	GHRHR	GHRH	Glucagon	B1 (Secretin)	Human	-	Nanobody-35	-	Somatoliberin pubchem	peptide	Agonist	GHRH	peptide	Cong Z, Zhou F, Zhang C, Zou X, Zhang H, Wang Y, Zhou Q, Cai X, Liu Q, Li J, Shao L, Mao C, Wang X, Wu J, Xia T, Zhao LH, Jiang H, Zhang Y, Xu HE, Cheng X, Yang D, Wang MW	10.1073/PNAS.2106606118	2021-10-20	56198
Gi/o	αi2	Human	-	61	β1	Human	γ2	Human	Cryo-EM	7F8V	-	3.3	GASR	CCK₂	Cholecystokinin	A (Rhodopsin)	Human	-	-	-	desulfated gastrin-17 pubchem gtoplig chembl_ligand pubchem	peptide	Agonist	CCK-39, desulfated gastrin-14, gastrin-71, desulfated gastrin-71, desulfated gastrin-17, gastrin-17, desulfated gastrin-34, desulfated cholecystokinin-8, gastrin-14, CCK-4, CCK-58, gastrin-34, CCK-8, CCK-33	peptide	Zhang X, He C, Wang M, Zhou Q, Yang D, Zhu Y, Feng W, Zhang H, Dai A, Chu X, Wang J, Yang Z, Jiang Y, Sensfuss U, Tan Q, Han S, Reedtz-Runge S, Xu HE, Zhao S, Wang MW, Wu B, Zhao Q	10.1038/S41589-021-00866-8	2021-10-13	56201
Gq/11	αq	Human	Gq-Gi1 chimera	61	β1	Rat	γ2	Bovine	Cryo-EM	7EIB	-	3.0	BKRB1	B₁	Bradykinin	A (Rhodopsin)	Human	-	-	-	[des-Arg¹⁰]kallidin pubchem gtoplig chembl_ligand gtoplig	peptide	Agonist	T-kinin, kallidin, Lys-[Hyp³]-bradykinin, bradykinin, [des-Arg¹⁰]kallidin, [Hyp³]bradykinin, [des-Arg⁹]bradykinin	peptide	Yin YL, Ye C, Zhou F, Wang J, Yang D, Yin W, Wang MW, Xu HE, Jiang Y	10.1038/S41594-021-00645-Y	2021-10-13	56208
Gq/11	αq	Human	Gq-Gi1 chimera	62	β1	Human	γ2	Human	Cryo-EM	7F8W	7F8W_refined	3.1	GASR	CCK₂	Cholecystokinin	A (Rhodopsin)	Human	-	scFv16	-	desulfated gastrin-17 pubchem gtoplig chembl_ligand pubchem	peptide	Agonist	CCK-39, desulfated gastrin-14, gastrin-71, desulfated gastrin-71, desulfated gastrin-17, gastrin-17, desulfated gastrin-34, desulfated cholecystokinin-8, gastrin-14, CCK-4, CCK-58, gastrin-34, CCK-8, CCK-33	peptide	Zhang X, He C, Wang M, Zhou Q, Yang D, Zhu Y, Feng W, Zhang H, Dai A, Chu X, Wang J, Yang Z, Jiang Y, Sensfuss U, Tan Q, Han S, Reedtz-Runge S, Xu HE, Zhao S, Wang MW, Wu B, Zhao Q	10.1038/S41589-021-00866-8	2021-10-13	56208
Gq/11	αq	Human	Gq-Gi1 chimera	60	β1	Rat	γ2	Bovine	Cryo-EM	7F2O	-	2.9	BKRB2	B₂	Bradykinin	A (Rhodopsin)	Human	-	scFv16	-	bradykinin pubchem gtoplig chembl_ligand drugbank gtoplig	peptide	Agonist	T-kinin, kallidin, Lys-[Hyp³]-bradykinin, bradykinin, [des-Arg¹⁰]kallidin, [Hyp³]bradykinin, [des-Arg⁹]bradykinin	peptide	Yin YL, Ye C, Zhou F, Wang J, Yang D, Yin W, Wang MW, Xu HE, Jiang Y	10.1038/S41594-021-00645-Y	2021-10-13	56208
Gs	αs	Human	-	60	β1	Human	γ2	Human	Cryo-EM	7RTB	7RTB_refined	2.1	GLP1R	GLP-1	Glucagon	B1 (Secretin)	Human	-	Nanobody-35	-	Peptide-19	peptide	Agonist	glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37)	peptide	Johnson RM, Zhang X, Piper SJ, Nettleton TJ, Vandekolk TH, Langmead CJ, Danev R, Sexton PM, Wootten D	10.1016/J.BBRC.2021.09.016	2021-10-06	56198
Gi/o	αi1	Human	-	64	β1	Human	γ2	Human	Cryo-EM	7EVY	-	3.0	S1PR1	S1P₁	Lysophospholipid (S1P)	A (Rhodopsin)	Human	-	scFv16	-	siponimod pubchem gtoplig chembl_ligand drug_central drugbank pubchem	small-molecule	Agonist	dihydrosphingosine 1-phosphate, sphingosylphosphorylcholine, sphingosine 1-phosphate	small-molecule	Yuan Y, Jia G, Wu C, Wang W, Cheng L, Li Q, Li Z, Luo K, Yang S, Yan W, Su Z, Shao Z	10.1038/S41422-021-00566-X	2021-09-29	56200
Gi/o	αi1	Human	-	64	β1	Human	γ2	Human	Cryo-EM	7EW0	7EW0_refined	3.4	S1PR1	S1P₁	Lysophospholipid (S1P)	A (Rhodopsin)	Human	-	scFv16	-	ozanimod pubchem gtoplig drug_central chembl_ligand drugbank pubchem	small-molecule	Agonist	dihydrosphingosine 1-phosphate, sphingosylphosphorylcholine, sphingosine 1-phosphate	small-molecule	Yuan Y, Jia G, Wu C, Wang W, Cheng L, Li Q, Li Z, Luo K, Yang S, Yan W, Su Z, Shao Z	10.1038/S41422-021-00566-X	2021-09-29	56200
Gi/o	αi1	Human	-	64	β1	Human	γ2	Human	Cryo-EM	7EW1	7EW1_refined	3.4	S1PR5	S1P₅	Lysophospholipid (S1P)	A (Rhodopsin)	Human	-	scFv16	-	siponimod pubchem gtoplig chembl_ligand drug_central drugbank pubchem	small-molecule	Agonist	dihydrosphingosine 1-phosphate, sphingosylphosphorylcholine, sphingosine 1-phosphate	small-molecule	Yuan Y, Jia G, Wu C, Wang W, Cheng L, Li Q, Li Z, Luo K, Yang S, Yan W, Su Z, Shao Z	10.1038/S41422-021-00566-X	2021-09-29	56200
Gi/o	αi1	Human	-	64	β1	Human	γ2	Human	Cryo-EM	7EW3	-	3.1	S1PR3	S1P₃	Lysophospholipid (S1P)	A (Rhodopsin)	Human	-	scFv16	-	Sphingosine 1-phosphate pubchem	lipid	Agonist	dihydrosphingosine 1-phosphate, sphingosylphosphorylcholine, sphingosine 1-phosphate	small-molecule	Zhao C, Cheng L, Wang W, Wang H, Luo Y, Feng Y, Wang X, Fu H, Cai Y, Yang S, Fu P, Yan W, Shao Z	10.1038/S41422-021-00567-W	2021-09-29	56200
Gi/o	αi1	Human	-	64	β1	Human	γ2	Human	Cryo-EM	7EVZ	-	3.1	S1PR1	S1P₁	Lysophospholipid (S1P)	A (Rhodopsin)	Human	-	scFv16	-	cenerimod pubchem gtoplig chembl_ligand drugbank pubchem	small-molecule	Agonist	dihydrosphingosine 1-phosphate, sphingosylphosphorylcholine, sphingosine 1-phosphate	small-molecule	Yuan Y, Jia G, Wu C, Wang W, Cheng L, Li Q, Li Z, Luo K, Yang S, Yan W, Su Z, Shao Z	10.1038/S41422-021-00566-X	2021-09-29	56200
Gi/o	αi1	Human	-	64	β1	Human	γ2	Human	Cryo-EM	7EW7	-	3.3	S1PR1	S1P₁	Lysophospholipid (S1P)	A (Rhodopsin)	Human	-	scFv16	-	SEW2871 pubchem gtoplig chembl_ligand	small-molecule	Agonist	dihydrosphingosine 1-phosphate, sphingosylphosphorylcholine, sphingosine 1-phosphate	small-molecule	Yuan Y, Jia G, Wu C, Wang W, Cheng L, Li Q, Li Z, Luo K, Yang S, Yan W, Su Z, Shao Z	10.1038/S41422-021-00566-X	2021-09-29	56200
Gi/o	αi1	Human	-	64	β1	Human	γ2	Human	Cryo-EM	7EW4	7EW4_refined	3.2	S1PR3	S1P₃	Lysophospholipid (S1P)	A (Rhodopsin)	Human	-	scFv16	-	CYM-5541 pubchem gtoplig chembl_ligand	small-molecule	Agonist	dihydrosphingosine 1-phosphate, sphingosylphosphorylcholine, sphingosine 1-phosphate	small-molecule	Zhao C, Cheng L, Wang W, Wang H, Luo Y, Feng Y, Wang X, Fu H, Cai Y, Yang S, Fu P, Yan W, Shao Z	10.1038/S41422-021-00567-W	2021-09-29	56200
Gi/o	αi1	Human	-	64	β1	Human	γ2	Human	Cryo-EM	7EW2	-	3.1	S1PR3	S1P₃	Lysophospholipid (S1P)	A (Rhodopsin)	Human	-	scFv16	-	(S)-FTY720-phosphate pubchem gtoplig chembl_ligand	small-molecule	Agonist	dihydrosphingosine 1-phosphate, sphingosylphosphorylcholine, sphingosine 1-phosphate	small-molecule	Zhao C, Cheng L, Wang W, Wang H, Luo Y, Feng Y, Wang X, Fu H, Cai Y, Yang S, Fu P, Yan W, Shao Z	10.1038/S41422-021-00567-W	2021-09-29	56200
Gs	αs	Bovine	-	91	β1	Rat	γ2	Bovine	Cryo-EM	7FII	-	4.3	LSHR	LH	Glycoprotein hormone	A (Rhodopsin)	Human	-	-	-	Glycoprotein alpha gtoplig Choriogonadotropin beta gtoplig	protein protein	Agonist	LH, hCG	peptide	Duan J, Xu P, Cheng X, Mao C, Croll T, He X, Shi J, Luan X, Yin W, You E, Liu Q, Zhang S, Jiang H, Zhang Y, Jiang Y, Xu HE	10.1038/S41586-021-03924-2	2021-09-29	56215
Gs	αs	Bovine	-	60	β1	Rat	γ2	Bovine	Cryo-EM	7FIH	-	3.2	LSHR	LH	Glycoprotein hormone	A (Rhodopsin)	Human	-	-	-	Glycoprotein alpha gtoplig Choriogonadotropin beta gtoplig 5-Amino-N-(1,1-dimethylethyl)-2-(methylthio)-4-[3-[[2-(4-morpholinyl)acetyl]amino]phenyl]thieno[2,3-d]pyrimidine-6-carboxamide pubchem	protein protein small-molecule	Agonist	LH, hCG	peptide	Duan J, Xu P, Cheng X, Mao C, Croll T, He X, Shi J, Luan X, Yin W, You E, Liu Q, Zhang S, Jiang H, Zhang Y, Jiang Y, Xu HE	10.1038/S41586-021-03924-2	2021-09-29	56215
Gs	αs	Bovine	-	91	β1	Rat	γ2	Bovine	Cryo-EM	7FIG	-	3.9	LSHR	LH	Glycoprotein hormone	A (Rhodopsin)	Human	-	Nanobody-35	-	Glycoprotein alpha gtoplig Choriogonadotropin beta gtoplig	protein protein	Agonist	LH, hCG	peptide	Duan J, Xu P, Cheng X, Mao C, Croll T, He X, Shi J, Luan X, Yin W, You E, Liu Q, Zhang S, Jiang H, Zhang Y, Jiang Y, Xu HE	10.1038/S41586-021-03924-2	2021-09-29	56215
Gi/o	αi2	Human	-	59	β1	Human	γ2	Human	Cryo-EM	7LD4	7LD4_refined	3.3	AA1R	A₁	Adenosine	A (Rhodopsin)	Human	-	-	-	adenosine pubchem gtoplig chembl_ligand drugbank drug_central pubchem	small-molecule	Agonist	adenosine	small-molecule	Draper-Joyce CJ, Bhola R, Wang J, Bhattarai A, Nguyen ATN, Cowie-Kent I, O'Sullivan K, Chia LY, Venugopal H, Valant C, Thal DM, Wootten D, Panel N, Carlsson J, Christie MJ, White PJ, Scammells P, May LT, Sexton PM, Danev R, Miao Y, Glukhova A, Imlach WL, Christopoulos A	10.1038/S41586-021-03897-2	2021-09-08	56201
Gi/o	αi2	Human	-	59	β1	Human	γ2	Human	Cryo-EM	7LD3	-	3.2	AA1R	A₁	Adenosine	A (Rhodopsin)	Human	-	-	-	{2-Amino-4-[3,5-bis(trifluoromethyl)phenyl]thiophen-3-yl}(4-chlorophenyl)methanone pubchem adenosine pubchem gtoplig chembl_ligand drugbank drug_central pubchem	small-molecule small-molecule	Ago-PAM Agonist	adenosine	small-molecule	Draper-Joyce CJ, Bhola R, Wang J, Bhattarai A, Nguyen ATN, Cowie-Kent I, O'Sullivan K, Chia LY, Venugopal H, Valant C, Thal DM, Wootten D, Panel N, Carlsson J, Christie MJ, White PJ, Scammells P, May LT, Sexton PM, Danev R, Miao Y, Glukhova A, Imlach WL, Christopoulos A	10.1038/S41586-021-03897-2	2021-09-08	56201
Gs	αs	Human	-	59	β1	Human	γ2	Human	Cryo-EM	7F4H	-	2.7	MSHR	MC₁	Melanocortin	A (Rhodopsin)	Human	-	Nanobody-35 scFv16	-	CHEMBL407070 chembl_ligand pubchem pubchem	protein	Agonist	γ-MSH, ACTH, β-MSH, α-MSH	peptide	Ma S, Chen Y, Dai A, Yin W, Guo J, Yang D, Zhou F, Jiang Y, Wang MW, Xu HE	10.1038/S41422-021-00557-Y	2021-09-08	56198
Gs	αs	Human	-	59	β1	Human	γ2	Human	Cryo-EM	7F4F	-	2.9	MSHR	MC₁	Melanocortin	A (Rhodopsin)	Human	-	scFv16	-	CHEMBL407070 chembl_ligand pubchem pubchem	protein	Agonist	γ-MSH, ACTH, β-MSH, α-MSH	peptide	Ma S, Chen Y, Dai A, Yin W, Guo J, Yang D, Zhou F, Jiang Y, Wang MW, Xu HE	10.1038/S41422-021-00557-Y	2021-09-08	56198
Gs	αs	Human	-	59	β1	Human	γ2	Human	Cryo-EM	7F4I	7F4I_refined	3.1	MSHR	MC₁	Melanocortin	A (Rhodopsin)	Human	-	Nanobody-35	-	bremelanotide pubchem gtoplig chembl_ligand drugbank drug_central pubchem	peptide	Agonist	γ-MSH, ACTH, β-MSH, α-MSH	peptide	Ma S, Chen Y, Dai A, Yin W, Guo J, Yang D, Zhou F, Jiang Y, Wang MW, Xu HE	10.1038/S41422-021-00557-Y	2021-09-08	56198
Gs	αs	Human	-	59	β1	Human	γ2	Human	Cryo-EM	7F4D	-	3.0	MSHR	MC₁	Melanocortin	A (Rhodopsin)	Human	-	Nanobody-35	-	INTERMEDINE chembl_ligand pubchem pubchem pubchem	protein	Agonist	γ-MSH, ACTH, β-MSH, α-MSH	peptide	Ma S, Chen Y, Dai A, Yin W, Guo J, Yang D, Zhou F, Jiang Y, Wang MW, Xu HE	10.1038/S41422-021-00557-Y	2021-09-08	56198
Gi/o	αi1	Human	-	61	β1	Human	γ2	Human	Cryo-EM	7EZH	-	3.2	CCKAR	CCK₁	Cholecystokinin	A (Rhodopsin)	Human	-	scFv16	-	CCK-8 pubchem gtoplig chembl_ligand drug_central drugbank	peptide	Agonist	CCK-39, gastrin-17, desulfated cholecystokinin-8, CCK-4, CCK-58, CCK-8, CCK-33	peptide	Liu Q, Yang D, Zhuang Y, Croll TI, Cai X, Dai A, He X, Duan J, Yin W, Ye C, Zhou F, Wu B, Zhao Q, Xu HE, Wang MW, Jiang Y	10.1038/S41589-021-00841-3	2021-08-25	56200
Gq/11	αq	Human	-	63	β1	Human	γ2	Human	Cryo-EM	7EZM	-	2.9	CCKAR	CCK₁	Cholecystokinin	A (Rhodopsin)	Human	-	scFv16	-	CCK-8 pubchem gtoplig chembl_ligand drug_central drugbank	peptide	Agonist	CCK-39, gastrin-17, desulfated cholecystokinin-8, CCK-4, CCK-58, CCK-8, CCK-33	peptide	Liu Q, Yang D, Zhuang Y, Croll TI, Cai X, Dai A, He X, Duan J, Yin W, Ye C, Zhou F, Wu B, Zhao Q, Xu HE, Wang MW, Jiang Y	10.1038/S41589-021-00841-3	2021-08-25	56208
Gs	αs	Human	-	58	β1	Human	γ2	Human	Cryo-EM	7EZK	-	3.1	CCKAR	CCK₁	Cholecystokinin	A (Rhodopsin)	Human	-	-	-	CCK-8 pubchem gtoplig chembl_ligand drug_central drugbank	peptide	Agonist	CCK-39, gastrin-17, desulfated cholecystokinin-8, CCK-4, CCK-58, CCK-8, CCK-33	peptide	Liu Q, Yang D, Zhuang Y, Croll TI, Cai X, Dai A, He X, Duan J, Yin W, Ye C, Zhou F, Wu B, Zhao Q, Xu HE, Wang MW, Jiang Y	10.1038/S41589-021-00841-3	2021-08-25	56198
Gi/o	αi1	Human	-	62	β1	Rat	γ2	Bovine	Cryo-EM	7DB6	7DB6_refined	3.3	MTR1A	MT₁	Melatonin	A (Rhodopsin)	Human	-	scFv16	-	ramelteon pubchem gtoplig chembl_ligand drugbank drug_central pubchem	small-molecule	Agonist	melatonin	small-molecule	Okamoto HH, Miyauchi H, Inoue A, Raimondi F, Tsujimoto H, Kusakizako T, Shihoya W, Yamashita K, Suno R, Nomura N, Kobayashi T, Iwata S, Nishizawa T, Nureki O	10.1038/S41594-021-00634-1	2021-08-18	56200
Gq/11	αq	Human	Engineered G alpha	59	β1	Human	γ2	Human	Cryo-EM	7F9Y	-	2.9	GHSR	ghrelin	Ghrelin	A (Rhodopsin)	Human	-	Nanobody-35	-	ghrelin gtoplig	peptide	Agonist	[des-Gln¹⁴]ghrelin, ghrelin	peptide	Wang Y, Guo S, Zhuang Y, Yun Y, Xu P, He X, Guo J, Yin W, Xu HE, Xie X, Jiang Y	10.1038/S41467-021-25364-2	2021-08-18	56208
Gq/11	αq	Human	Engineered G alpha	59	β1	Human	γ2	Human	Cryo-EM	7F9Z	7F9Z_refined	3.2	GHSR	ghrelin	Ghrelin	A (Rhodopsin)	Human	-	Nanobody-35 scFv16	-	GHRP-6 pubchem gtoplig	peptide	Agonist	[des-Gln¹⁴]ghrelin, ghrelin	peptide	Wang Y, Guo S, Zhuang Y, Yun Y, Xu P, He X, Guo J, Yin W, Xu HE, Xie X, Jiang Y	10.1038/S41467-021-25364-2	2021-08-18	56208
Gs	αs	Human	-	58	β1	Rat	γ2	Bovine	Cryo-EM	7F16	-	2.8	PTH2R	PTH2	Parathyroid hormone	B1 (Secretin)	Human	-	Nanobody-35	-	TIP39 gtoplig	peptide	Agonist	PTHrP-(1-34) (human), PTH, TIP39, PTHrP, PTHrP-(1-36)	peptide	Wang X, Cheng X, Zhao L, Wang Y, Ye C, Zou X, Dai A, Cong Z, Chen J, Zhou Q, Xia T, Jiang H, Xu HE, Yang D, Wang MW	10.1073/PNAS.2101279118	2021-08-18	56198
Gs	αs	Human	-	60	β1	Rat	γ2	Bovine	Cryo-EM	7DUR	-	3.3	GLP1R	GLP-1	Glucagon	B1 (Secretin)	Human	-	Nanobody-35	-	N-Tert-butyl-6,7-dichloroquinoxalin-2-amine pubchem	small-molecule	Ago-PAM	glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37)	peptide	Cong Z, Chen LN, Ma H, Zhou Q, Zou X, Ye C, Dai A, Liu Q, Huang W, Sun X, Wang X, Xu P, Zhao L, Xia T, Zhong W, Yang D, Eric Xu H, Zhang Y, Wang MW	10.1038/S41467-021-24058-Z	2021-08-11	56198
Gs	αs	Human	-	60	β1	Rat	γ2	Bovine	Cryo-EM	7EVM	-	2.5	GLP1R	GLP-1	Glucagon	B1 (Secretin)	Human	-	Nanobody-35	-	N-Tert-butyl-6,7-dichloroquinoxalin-2-amine pubchem	small-molecule	Ago-PAM	glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37)	peptide	Cong Z, Chen LN, Ma H, Zhou Q, Zou X, Ye C, Dai A, Liu Q, Huang W, Sun X, Wang X, Xu P, Zhao L, Xia T, Zhong W, Yang D, Eric Xu H, Zhang Y, Wang MW	10.1038/S41467-021-24058-Z	2021-08-11	56198
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	7EXD	7EXD_refined	3.4	5HT1F	5-HT_1F	5-Hydroxytryptamine	A (Rhodopsin)	Human	BRIL	scFv16	-	lasmiditan pubchem gtoplig chembl_ligand drug_central drugbank pubchem	small-molecule	Agonist	5-hydroxytryptamine	small-molecule	Huang S, Xu P, Tan Y, You C, Zhang Y, Jiang Y, Xu HE	10.1038/S41422-021-00527-4	2021-08-04	56200
Gs	αs	Bovine	-	59	β1	Rat	γ2	Bovine	Cryo-EM	7DTY	-	3.0	GIPR	GIP	Glucagon	B1 (Secretin)	Human	-	Nanobody-35	-	GIP pubchem	small-molecule	Agonist	gastric inhibitory polypeptide	peptide	Zhao F, Zhang C, Zhou Q, Hang K, Zou X, Chen Y, Wu F, Rao Q, Dai A, Yin W, Shen DD, Zhang Y, Xia T, Stevens RC, Xu HE, Yang D, Zhao L, Wang MW	10.7554/ELIFE.68719	2021-08-04	56215
Gs	αs	Human	-	53	β1	Human	γ2	Human	Cryo-EM	7KI0	-	2.5	GLP1R	GLP-1	Glucagon	B1 (Secretin)	Human	-	Nanobody-35	-	semaglutide pubchem gtoplig chembl_ligand drugbank pubchem chembl_ligand pubchem	peptide	Agonist	glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37)	peptide	Zhang X, Belousoff MJ, Liang YL, Danev R, Sexton PM, Wootten D	10.1016/J.CELREP.2021.109374	2021-08-04	56198
Gs	αs	Human	-	89	β1	Human	γ2	Human	Cryo-EM	7KI1	-	2.5	GLP1R	GLP-1	Glucagon	B1 (Secretin)	Human	-	Nanobody-35	-	taspoglutide pubchem gtoplig drugbank	peptide	Agonist	glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37)	peptide	Zhang X, Belousoff MJ, Liang YL, Danev R, Sexton PM, Wootten D	10.1016/J.CELREP.2021.109374	2021-08-04	56198
Gs	αs	Human	-	59	β1	Rat	γ2	Bovine	Cryo-EM	7DH5	-	3.2	ADRB3	β₃	Adrenoceptors	A (Rhodopsin)	Dog	-	Nanobody-35	-	mirabegron pubchem gtoplig chembl_ligand drugbank drug_central pubchem	small-molecule	Agonist	-	-	Nagiri C, Kobayashi K, Tomita A, Kato M, Kobayashi K, Yamashita K, Nishizawa T, Inoue A, Shihoya W, Nureki O	10.1016/J.MOLCEL.2021.06.024	2021-08-04	56198
Gs	αs	Human	-	59	β1	Human	γ2	Human	Cryo-EM	7EVW	-	3.2	FZD7	FZD₇	Frizzled	F (Frizzled)	Human	-	Nanobody-35	-	Apo (no ligand)	none	Apo (no ligand)	-	-	Xu L, Chen B, Schihada H, Wright SC, Turku A, Wu Y, Han GW, Kowalski-Jahn M, Kozielewicz P, Bowin CF, Zhang X, Li C, Bouvier M, Schulte G, Xu F	10.1038/S41422-021-00525-6	2021-08-04	56198
Gs	αs	Human	-	60	β1	Rat	γ2	Bovine	Cryo-EM	7DW9	-	2.6	V2R	V₂	Vasopressin and oxytocin	A (Rhodopsin)	Human	-	Nanobody-35 scFv16	-	vasopressin pubchem gtoplig chembl_ligand drugbank drug_central pubchem	peptide	Agonist	oxytocin, vasopressin	peptide	Zhou F, Ye C, Ma X, Yin W, Croll TI, Zhou Q, He X, Zhang X, Yang D, Wang P, Xu HE, Wang MW, Jiang Y	10.1038/S41422-021-00480-2	2021-07-21	56198
Gi/o	αi1	Human	-	61	β1	Human	γ2	Human	Cryo-EM	7F1S	7F1S_refined	2.8	CCR5	CCR5	Chemokine	A (Rhodopsin)	Human	-	-	-	Apo (no ligand)	none	Apo (no ligand)	CCL13, CCL11, CCL8, CCL2, CCL7, CCL4, CCL5, CCL14, CCL3, CCL16	peptide	Zhang H, Chen K, Tan Q, Shao Q, Han S, Zhang C, Yi C, Chu X, Zhu Y, Xu Y, Zhao Q, Wu B	10.1038/S41467-021-24438-5	2021-07-14	56200
Gi/o	αi1	Human	-	61	β1	Human	γ2	Human	Cryo-EM	7F1R	-	3.0	CCR5	CCR5	Chemokine	A (Rhodopsin)	Human	-	-	-	CCL5 gtoplig	peptide	Agonist	CCL13, CCL11, CCL8, CCL2, CCL7, CCL4, CCL5, CCL14, CCL3, CCL16	peptide	-	-	2021-07-14	56200
Gi/o	αi1	Human	-	61	β1	Human	γ2	Human	Cryo-EM	7F1Q	-	2.9	CCR5	CCR5	Chemokine	A (Rhodopsin)	Human	-	-	-	CCL3 gtoplig	peptide	Agonist	CCL13, CCL11, CCL8, CCL2, CCL7, CCL4, CCL5, CCL14, CCL3, CCL16	peptide	-	-	2021-07-14	56200
Gs	αs	Human	-	61	β1	Rat	γ2	Bovine	Cryo-EM	7DUQ	-	2.5	GLP1R	GLP-1	Glucagon	B1 (Secretin)	Human	-	Nanobody-35	-	N-Tert-butyl-6,7-dichloroquinoxalin-2-amine pubchem CHEMBL410972 chembl_ligand pubchem pubchem	small-molecule protein	Ago-PAM Agonist	glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37)	peptide	Cong Z, Chen LN, Ma H, Zhou Q, Zou X, Ye C, Dai A, Liu Q, Huang W, Sun X, Wang X, Xu P, Zhao L, Xia T, Zhong W, Yang D, Eric Xu H, Zhang Y, Wang MW	10.1038/S41467-021-24058-Z	2021-07-14	56198
Gi/o	αi1	Human	-	58	β1	Human	γ2	Human	Cryo-EM	7MTS	-	3.2	GRM2	mGlu₂	Metabotropic glutamate	C (Glutamate)	Human	-	-	-	2-methoxy-6-propyl-N-(2-{4-[(1H-tetrazol-5-yl)methoxy]phenyl}ethyl)thieno[2,3-d]pyrimidin-4-amine pubchem L-glutamic acid pubchem gtoplig chembl_ligand drugbank drug_central pubchem pubchem	small-molecule small-molecule	Ago-PAM Agonist	L-glutamic acid	small-molecule	Seven AB, Barros-Alvarez X, de Lapeyriere M, Papasergi-Scott MM, Robertson MJ, Zhang C, Nwokonko RM, Gao Y, Meyerowitz JG, Rocher JP, Schelshorn D, Kobilka BK, Mathiesen JM, Skiniotis G	10.1038/S41586-021-03680-3	2021-07-07	56200
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	7JHJ	-	3.2	Q3KSP2	BILF1	Unclassified	A (Rhodopsin)	strain GD1	-	scFv16	-	Apo (no ligand)	none	Apo (no ligand)	-	-	Tsutsumi N, Qu Q, Mavri M, Baggesen MS, Maeda S, Waghray D, Berg C, Kobilka BK, Rosenkilde MM, Skiniotis G, Garcia KC	10.1016/J.IMMUNI.2021.06.001	2021-07-07	56200
Gs	αs	Human	-	49	β1	Bovine	γ2	Mouse	Cryo-EM	7E14	-	2.9	GLP1R	GLP-1	Glucagon	B1 (Secretin)	Human	-	Nanobody-35	-	N-Tert-butyl-6,7-dichloroquinoxalin-2-amine pubchem orforglipron pubchem gtoplig chembl_ligand drugbank pubchem	small-molecule small-molecule	Ago-PAM Agonist	glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37)	peptide	Cong Z, Chen LN, Ma H, Zhou Q, Zou X, Ye C, Dai A, Liu Q, Huang W, Sun X, Wang X, Xu P, Zhao L, Xia T, Zhong W, Yang D, Eric Xu H, Zhang Y, Wang MW	10.1038/S41467-021-24058-Z	2021-07-07	56198
Gi/o	αi1	Human	-	62	β1	Bovine	γ2	Bovine	Cryo-EM	7O7F	7O7F_refined	3.2	CCR5	CCR5	Chemokine	A (Rhodopsin)	Human	-	Fab heavy chain Fab light chain	-	CCL5 gtoplig	peptide	Agonist	CCL13, CCL11, CCL8, CCL2, CCL7, CCL4, CCL5, CCL14, CCL3, CCL16	peptide	Isaikina P, Tsai CJ, Dietz N, Pamula F, Grahl A, Goldie KN, Guixa-Gonzalez R, Branco C, Paolini-Bertrand M, Calo N, Cerini F, Schertler GFX, Hartley O, Stahlberg H, Maier T, Deupi X, Grzesiek S	10.1126/SCIADV.ABG8685	2021-06-30	56200
Gi/o	αi3	Human	-	63	β1	Human	γ2	Human	Cryo-EM	7E9H	-	4.0	GRM4	mGlu₄	Metabotropic glutamate	C (Glutamate)	Human	-	scFv16	-	L-serine-O-phosphate pubchem gtoplig chembl_ligand drugbank drug_central pubchem	small-molecule	Agonist	L-serine-O-phosphate, L-glutamic acid	small-molecule	Lin S, Han S, Cai X, Tan Q, Zhou K, Wang D, Wang X, Du J, Yi C, Chu X, Dai A, Zhou Y, Chen Y, Zhou Y, Liu H, Liu J, Yang D, Wang MW, Zhao Q, Wu B	10.1038/S41586-021-03495-2	2021-06-23	56202
Gi/o	αi1	Human	-	63	β1	Human	γ2	Human	Cryo-EM	7E9G	-	3.5	GRM2	mGlu₂	Metabotropic glutamate	C (Glutamate)	Human	-	scFv16	DN13	eglumegad pubchem gtoplig chembl_ligand gtoplig JNJ-40411813 pubchem gtoplig chembl_ligand drugbank	small-molecule small-molecule	Agonist PAM	L-glutamic acid	small-molecule	Lin S, Han S, Cai X, Tan Q, Zhou K, Wang D, Wang X, Du J, Yi C, Chu X, Dai A, Zhou Y, Chen Y, Zhou Y, Liu H, Liu J, Yang D, Wang MW, Zhao Q, Wu B	10.1038/S41586-021-03495-2	2021-06-23	56200
Gs	αs	Human	-	54	β1	Human	γ2	Human	Cryo-EM	7BB6	-	4.2	V2R	V₂	Vasopressin and oxytocin	A (Rhodopsin)	Human	-	Nanobody-35	-	vasopressin pubchem gtoplig chembl_ligand drugbank drug_central pubchem	peptide	Agonist	oxytocin, vasopressin	peptide	Bous J, Orcel H, Floquet N, Leyrat C, Lai-Kee-Him J, Gaibelet G, Ancelin A, Saint-Paul J, Trapani S, Louet M, Sounier R, Demene H, Granier S, Bron P, Mouillac B	10.1126/SCIADV.ABG5628	2021-06-02	56198
Gs	αs	Human	-	55	β1	Human	γ2	Human	Cryo-EM	7BB7	-	4.4	V2R	V₂	Vasopressin and oxytocin	A (Rhodopsin)	Human	-	Nanobody-35	-	vasopressin pubchem gtoplig chembl_ligand drugbank drug_central pubchem	peptide	Agonist	oxytocin, vasopressin	peptide	Bous J, Orcel H, Floquet N, Leyrat C, Lai-Kee-Him J, Gaibelet G, Ancelin A, Saint-Paul J, Trapani S, Louet M, Sounier R, Demene H, Granier S, Bron P, Mouillac B	10.1126/SCIADV.ABG5628	2021-06-02	56198
Gq/11	αq	Human	Gq-Gs-Gi1 chimera	55	β1	Rat	γ2	Human	Cryo-EM	7MBY	-	2.4	CCKAR	CCK₁	Cholecystokinin	A (Rhodopsin)	Human	-	-	-	CHEMBL216166 chembl_ligand pubchem	protein	Agonist	CCK-39, gastrin-17, desulfated cholecystokinin-8, CCK-4, CCK-58, CCK-8, CCK-33	peptide	Mobbs JI, Belousoff MJ, Harikumar KG, Piper SJ, Xu X, Furness SGB, Venugopal H, Christopoulos A, Danev R, Wootten D, Thal DM, Miller LJ, Sexton PM	10.1371/JOURNAL.PBIO.3001295	2021-05-26	56208
Gs	αs	Human	-	58	β1	Human	γ2	Human	Cryo-EM	7KH0	-	2.8	V2R	V₂	Vasopressin and oxytocin	A (Rhodopsin)	Human	-	scFv16 Nanobody-35	-	vasopressin pubchem gtoplig chembl_ligand drugbank drug_central pubchem	peptide	Agonist	oxytocin, vasopressin	peptide	Wang L, Xu J, Cao S, Sun D, Liu H, Lu Q, Liu Z, Du Y, Zhang C	10.1038/S41422-021-00483-Z	2021-05-26	56198
Gs	αs	Human	-	61	β1	Rat	γ2	Human	Cryo-EM	7MBX	-	2.0	CCKAR	CCK₁	Cholecystokinin	A (Rhodopsin)	Human	-	Nanobody-35	-	CHEMBL216166 chembl_ligand pubchem	protein	Agonist	CCK-39, gastrin-17, desulfated cholecystokinin-8, CCK-4, CCK-58, CCK-8, CCK-33	peptide	Mobbs JI, Belousoff MJ, Harikumar KG, Piper SJ, Xu X, Furness SGB, Venugopal H, Christopoulos A, Danev R, Wootten D, Thal DM, Miller LJ, Sexton PM	10.1371/JOURNAL.PBIO.3001295	2021-05-26	56198
Gi/o	αi1	Human	-	99	β1	Human	γ2	Human	Cryo-EM	7EB2	-	3.5	GABR2	GABA_B2	GABA_B	C (Glutamate)	Human	-	scFv16	-	(-)-baclofen pubchem gtoplig chembl_ligand drugbank drugbank gtoplig pubchem pubchem BHFF pubchem	small-molecule small-molecule	Agonist PAM	-	-	Shen C, Mao C, Xu C, Jin N, Zhang H, Shen DD, Shen Q, Wang X, Hou T, Chen Z, Rondard P, Pin JP, Zhang Y, Liu J	10.1038/S41586-021-03507-1	2021-05-05	56200
Gs	αs	Human	-	58	β1	Human	γ2	Human	Cryo-EM	7CX3	-	2.8	PE2R2	EP₂	Prostanoid	A (Rhodopsin)	Human	-	Nanobody-35	-	taprenepag pubchem gtoplig chembl_ligand drugbank	small-molecule	Agonist	PGE₁, PGF_2α, PGI₂, PGE₂, thromboxane A₂, PGD₂	small-molecule	Qu C, Mao C, Xiao P, Shen Q, Zhong YN, Yang F, Shen DD, Tao X, Zhang H, Yan X, Zhao RJ, He J, Guan Y, Zhang C, Hou G, Zhang PJ, Hou G, Li Z, Yu X, Chai RJ, Guan YF, Sun JP, Zhang Y	10.1126/SCIADV.ABF1268	2021-05-05	56198
Gs	αs	Human	-	58	β1	Human	γ2	Human	Cryo-EM	7CX2	-	2.8	PE2R2	EP₂	Prostanoid	A (Rhodopsin)	Human	-	Nanobody-35	-	PGE₂ pubchem gtoplig chembl_ligand drugbank drug_central gtoplig pubchem	small-molecule	Agonist	PGE₁, PGF_2α, PGI₂, PGE₂, thromboxane A₂, PGD₂	small-molecule	Qu C, Mao C, Xiao P, Shen Q, Zhong YN, Yang F, Shen DD, Tao X, Zhang H, Yan X, Zhao RJ, He J, Guan Y, Zhang C, Hou G, Zhang PJ, Hou G, Li Z, Yu X, Chai RJ, Guan YF, Sun JP, Zhang Y	10.1126/SCIADV.ABF1268	2021-05-05	56198
Gs	αs	Human	-	58	β1	Human	γ2	Human	Cryo-EM	7CX4	7CX4_refined	2.9	PE2R2	EP₂	Prostanoid	A (Rhodopsin)	Human	-	Nanobody-35	-	evatanepag pubchem gtoplig chembl_ligand drugbank	small-molecule	Agonist	PGE₁, PGF_2α, PGI₂, PGE₂, thromboxane A₂, PGD₂	small-molecule	Qu C, Mao C, Xiao P, Shen Q, Zhong YN, Yang F, Shen DD, Tao X, Zhang H, Yan X, Zhao RJ, He J, Guan Y, Zhang C, Hou G, Zhang PJ, Hou G, Li Z, Yu X, Chai RJ, Guan YF, Sun JP, Zhang Y	10.1126/SCIADV.ABF1268	2021-05-05	56198
Gs	αs	Human	-	59	β1	Human	γ2	Human	Cryo-EM	7AUE	7AUE_refined	3.0	MC4R	MC₄	Melanocortin	A (Rhodopsin)	Human	-	scFv16	-	setmelanotide pubchem gtoplig drug_central chembl_ligand drugbank pubchem	peptide	Agonist	γ-MSH, α-MSH, β-MSH, ACTH, agouti-related protein	peptide	Israeli H, Degtjarik O, Fierro F, Chunilal V, Gill AK, Roth NJ, Botta J, Prabahar V, Peleg Y, Chan LF, Ben-Zvi D, McCormick PJ, Niv MY, Shalev-Benami M	10.1126/SCIENCE.ABF7958	2021-04-28	56198
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	7E32	-	2.9	5HT1D	5-HT_1D	5-Hydroxytryptamine	A (Rhodopsin)	Human	-	scFv16	-	5-hydroxytryptamine pubchem gtoplig chembl_ligand drugbank	small-molecule	Agonist	5-HT-moduline, 5-hydroxytryptamine	small-molecule	Xu P, Huang S, Zhang H, Mao C, Zhou XE, Cheng X, Simon IA, Shen DD, Yen HY, Robinson CV, Harpsoe K, Svensson B, Guo J, Jiang H, Gloriam DE, Melcher K, Jiang Y, Zhang Y, Xu HE	10.1038/S41586-021-03376-8	2021-04-21	56200
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	7E2Z	-	3.1	5HT1A	5-HT_1A	5-Hydroxytryptamine	A (Rhodopsin)	Human	-	-	-	aripiprazole pubchem gtoplig chembl_ligand drugbank drug_central pubchem	small-molecule	Agonist (partial)	5-hydroxytryptamine	small-molecule	Xu P, Huang S, Zhang H, Mao C, Zhou XE, Cheng X, Simon IA, Shen DD, Yen HY, Robinson CV, Harpsoe K, Svensson B, Guo J, Jiang H, Gloriam DE, Melcher K, Jiang Y, Zhang Y, Xu HE	10.1038/S41586-021-03376-8	2021-04-14	56200
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	7E2Y	-	3.0	5HT1A	5-HT_1A	5-Hydroxytryptamine	A (Rhodopsin)	Human	-	-	-	5-hydroxytryptamine pubchem gtoplig chembl_ligand drugbank	small-molecule	Agonist	5-hydroxytryptamine	small-molecule	Xu P, Huang S, Zhang H, Mao C, Zhou XE, Cheng X, Simon IA, Shen DD, Yen HY, Robinson CV, Harpsoe K, Svensson B, Guo J, Jiang H, Gloriam DE, Melcher K, Jiang Y, Zhang Y, Xu HE	10.1038/S41586-021-03376-8	2021-04-14	56200
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	7E2X	-	3.0	5HT1A	5-HT_1A	5-Hydroxytryptamine	A (Rhodopsin)	Human	-	-	-	Apo (no ligand)	none	Apo (no ligand)	5-hydroxytryptamine	small-molecule	Xu P, Huang S, Zhang H, Mao C, Zhou XE, Cheng X, Simon IA, Shen DD, Yen HY, Robinson CV, Harpsoe K, Svensson B, Guo J, Jiang H, Gloriam DE, Melcher K, Jiang Y, Zhang Y, Xu HE	10.1038/S41586-021-03376-8	2021-04-14	56200
Gi/o	αi1	Human	-	61	β1	Human	γ2	Human	Cryo-EM	7E33	7E33_refined	2.9	5HT1E	5-HT_1E	5-Hydroxytryptamine	A (Rhodopsin)	Human	-	scFv16	-	BRL-54443 pubchem gtoplig chembl_ligand	small-molecule	Agonist	tryptamine, 5-hydroxytryptamine	small-molecule	Xu P, Huang S, Zhang H, Mao C, Zhou XE, Cheng X, Simon IA, Shen DD, Yen HY, Robinson CV, Harpsoe K, Svensson B, Guo J, Jiang H, Gloriam DE, Melcher K, Jiang Y, Zhang Y, Xu HE	10.1038/S41586-021-03376-8	2021-04-14	56200
Gs	αs	Human	-	86	β1	Human	γ2	Human	X-ray	7JOZ	7JOZ_refined	3.8	DRD1	D₁	Dopamine	A (Rhodopsin)	Human	-	Nanobody-35	-	CHEMBL4453318 chembl_ligand pubchem	small-molecule	Agonist	noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, dopamine, 5-hydroxytryptamine	small-molecule	Sun B, Feng D, Chu ML, Fish I, Lovera S, Sands ZA, Kelm S, Valade A, Wood M, Ceska T, Kobilka TS, Lebon F, Kobilka BK	10.1038/S41467-021-23519-9	2021-04-14	56198
Gq/11	αq	Human	-	63	β1	Human	γ2	Human	Cryo-EM	7DFL	-	3.3	HRH1	H₁	Histamine	A (Rhodopsin)	Human	-	scFv16	-	histamine pubchem gtoplig chembl_ligand drug_central drugbank gtoplig pubchem	small-molecule	Agonist	histamine	small-molecule	Xia R, Wang N, Xu Z, Lu Y, Song J, Zhang A, Guo C, He Y	10.1038/S41467-021-22427-2	2021-03-31	56208
Gs	αs2	Human	-	96	-	-	-	-	X-ray	7BPH	-	1.6	-	-	-	-	-	-	-	GN13	-	-	-	-	-	Dai SA, Hu Q, Gao R, Blythe EE, Touhara KK, Peacock H, Zhang Z, von Zastrow M, Suga H, Shokat KM	36170854	2021-03-31	56198
Gi/o	αi1	Human	-	64	β1	Human	γ2	Human	Cryo-EM	7CMV	-	2.7	DRD3	D₃	Dopamine	A (Rhodopsin)	Human	BRIL	scFv16	-	CHEMBL70565 chembl_ligand chembl_ligand pubchem	small-molecule	Agonist	dopamine	small-molecule	Xu P, Huang S, Mao C, Krumm BE, Zhou XE, Tan Y, Huang XP, Liu Y, Shen DD, Jiang Y, Yu X, Jiang H, Melcher K, Roth BL, Cheng X, Zhang Y, Xu HE	10.1016/J.MOLCEL.2021.01.003	2021-03-10	56200
Gi/o	αi1	Human	-	64	β1	Human	γ2	Human	Cryo-EM	7CMU	-	3.0	DRD3	D₃	Dopamine	A (Rhodopsin)	Human	BRIL	scFv16	-	pramipexole pubchem gtoplig chembl_ligand drugbank drug_central pubchem	small-molecule	Agonist	dopamine	small-molecule	Xu P, Huang S, Mao C, Krumm BE, Zhou XE, Tan Y, Huang XP, Liu Y, Shen DD, Jiang Y, Yu X, Jiang H, Melcher K, Roth BL, Cheng X, Zhang Y, Xu HE	10.1016/J.MOLCEL.2021.01.003	2021-03-10	56200
Gs	αs	Human	Engineered G alpha	60	β1	Rat	γ2	Bovine	Cryo-EM	7LJC	-	3.0	DRD1	D₁	Dopamine	A (Rhodopsin)	Human	-	Nanobody-35	-	CHEMBL1160787 chembl_ligand pubchem mevidalen pubchem gtoplig chembl_ligand pubchem	small-molecule small-molecule	Agonist PAM	noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, dopamine, 5-hydroxytryptamine	small-molecule	Zhuang Y, Krumm B, Zhang H, Zhou XE, Wang Y, Huang XP, Liu Y, Cheng X, Jiang Y, Jiang H, Zhang C, Yi W, Roth BL, Zhang Y, Xu HE	10.1038/S41422-021-00482-0	2021-03-03	56198
Gs	αs	Human	-	60	β1	Human	γ2	Human	Cryo-EM	7CKY	-	3.2	DRD1	D₁	Dopamine	A (Rhodopsin)	Human	-	Nanobody-35	-	CHEMBL3697578 chembl_ligand pubchem	small-molecule	Agonist	noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, dopamine, 5-hydroxytryptamine	small-molecule	Xiao P, Yan W, Gou L, Zhong YN, Kong L, Wu C, Wen X, Yuan Y, Cao S, Qu C, Yang X, Yang CC, Xia A, Hu Z, Zhang Q, He YH, Zhang DL, Zhang C, Hou GH, Liu H, Zhu L, Fu P, Yang S, Rosenbaum DM, Sun JP, Du Y, Zhang L, Yu X, Shao Z	10.1016/J.CELL.2021.01.028	2021-03-03	56198
Gs	αs	Human	-	60	β1	Human	γ2	Human	Cryo-EM	7CKZ	-	3.1	DRD1	D₁	Dopamine	A (Rhodopsin)	Human	-	Nanobody-35	-	dopamine pubchem gtoplig chembl_ligand drugbank drug_central pubchem mevidalen pubchem gtoplig chembl_ligand pubchem	small-molecule small-molecule	Agonist PAM	noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, dopamine, 5-hydroxytryptamine	small-molecule	Xiao P, Yan W, Gou L, Zhong YN, Kong L, Wu C, Wen X, Yuan Y, Cao S, Qu C, Yang X, Yang CC, Xia A, Hu Z, Zhang Q, He YH, Zhang DL, Zhang C, Hou GH, Liu H, Zhu L, Fu P, Yang S, Rosenbaum DM, Sun JP, Du Y, Zhang L, Yu X, Shao Z	10.1016/J.CELL.2021.01.028	2021-03-03	56198
Gs	αs	Human	-	60	β1	Human	γ2	Human	Cryo-EM	7CKX	-	3.5	DRD1	D₁	Dopamine	A (Rhodopsin)	Human	-	Nanobody-35	-	A77636 pubchem gtoplig chembl_ligand	small-molecule	Agonist	noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, dopamine, 5-hydroxytryptamine	small-molecule	Xiao P, Yan W, Gou L, Zhong YN, Kong L, Wu C, Wen X, Yuan Y, Cao S, Qu C, Yang X, Yang CC, Xia A, Hu Z, Zhang Q, He YH, Zhang DL, Zhang C, Hou GH, Liu H, Zhu L, Fu P, Yang S, Rosenbaum DM, Sun JP, Du Y, Zhang L, Yu X, Shao Z	10.1016/J.CELL.2021.01.028	2021-03-03	56198
Gs	αs	Human	-	60	β1	Human	γ2	Human	Cryo-EM	7CKW	7CKW_refined	3.2	DRD1	D₁	Dopamine	A (Rhodopsin)	Human	-	Nanobody-35	-	fenoldopam pubchem gtoplig chembl_ligand drugbank drug_central pubchem gtoplig chembl_ligand pubchem pubchem gtoplig chembl_ligand pubchem pubchem	small-molecule	Agonist	noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, dopamine, 5-hydroxytryptamine	small-molecule	Xiao P, Yan W, Gou L, Zhong YN, Kong L, Wu C, Wen X, Yuan Y, Cao S, Qu C, Yang X, Yang CC, Xia A, Hu Z, Zhang Q, He YH, Zhang DL, Zhang C, Hou GH, Liu H, Zhu L, Fu P, Yang S, Rosenbaum DM, Sun JP, Du Y, Zhang L, Yu X, Shao Z	10.1016/J.CELL.2021.01.028	2021-03-03	56198
Gs	αs	Human	Engineered G alpha	60	β1	Rat	γ2	Bovine	Cryo-EM	7LJD	-	3.2	DRD1	D₁	Dopamine	A (Rhodopsin)	Human	-	Nanobody-35	-	dopamine pubchem gtoplig chembl_ligand drugbank drug_central pubchem mevidalen pubchem gtoplig chembl_ligand pubchem	small-molecule small-molecule	Agonist PAM	noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, dopamine, 5-hydroxytryptamine	small-molecule	-	-	2021-03-03	56198
Gs	αs	Human	-	60	β1	Human	γ2	Human	Cryo-EM	7CRH	7CRH_refined	3.3	DRD1	D₁	Dopamine	A (Rhodopsin)	Human	-	Nanobody-35	-	CHEMBL1416789 chembl_ligand pubchem	small-molecule	Agonist	noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, dopamine, 5-hydroxytryptamine	small-molecule	Xiao P, Yan W, Gou L, Zhong YN, Kong L, Wu C, Wen X, Yuan Y, Cao S, Qu C, Yang X, Yang CC, Xia A, Hu Z, Zhang Q, He YH, Zhang DL, Zhang C, Hou GH, Liu H, Zhu L, Fu P, Yang S, Rosenbaum DM, Sun JP, Du Y, Zhang L, Yu X, Shao Z	10.1016/J.CELL.2021.01.028	2021-03-03	56198
Gi/o	αi1	Human	-	63	β1	Human	γ2	Human	Cryo-EM	7JVR	-	2.8	DRD2	D₂	Dopamine	A (Rhodopsin)	Human	-	scFv16	-	bromocriptine pubchem gtoplig chembl_ligand drugbank drug_central pubchem	small-molecule	Agonist	dopamine	small-molecule	Zhuang Y, Xu P, Mao C, Wang L, Krumm B, Zhou XE, Huang S, Liu H, Cheng X, Huang XP, Shen DD, Xu T, Liu YF, Wang Y, Guo J, Jiang Y, Jiang H, Melcher K, Roth BL, Zhang Y, Zhang C, Xu HE	10.1016/J.CELL.2021.01.027	2021-02-24	56200
Gs	αs	Human	-	60	β1	Human	γ2	Human	Cryo-EM	7JVP	-	2.9	DRD1	D₁	Dopamine	A (Rhodopsin)	Human	-	Nanobody-35	-	39YLC3L0ZU pubchem	small-molecule	Agonist	noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, dopamine, 5-hydroxytryptamine	small-molecule	Zhuang Y, Xu P, Mao C, Wang L, Krumm B, Zhou XE, Huang S, Liu H, Cheng X, Huang XP, Shen DD, Xu T, Liu YF, Wang Y, Guo J, Jiang Y, Jiang H, Melcher K, Roth BL, Zhang Y, Zhang C, Xu HE	10.1016/J.CELL.2021.01.027	2021-02-24	56198
Gs	αs	Human	-	60	β1	Human	γ2	Human	Cryo-EM	7JV5	-	3.0	DRD1	D₁	Dopamine	A (Rhodopsin)	Human	-	Nanobody-35	-	CHEMBL1160787 chembl_ligand pubchem	small-molecule	Agonist	noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, dopamine, 5-hydroxytryptamine	small-molecule	Zhuang Y, Xu P, Mao C, Wang L, Krumm B, Zhou XE, Huang S, Liu H, Cheng X, Huang XP, Shen DD, Xu T, Liu YF, Wang Y, Guo J, Jiang Y, Jiang H, Melcher K, Roth BL, Zhang Y, Zhang C, Xu HE	10.1016/J.CELL.2021.01.027	2021-02-24	56198
Gs	αs	Human	Engineered G alpha	60	β1	Human	γ2	Human	Cryo-EM	7JVQ	7JVQ_refined	3.0	DRD1	D₁	Dopamine	A (Rhodopsin)	Human	-	Nanobody-35	-	apomorphine pubchem gtoplig chembl_ligand drugbank drug_central pubchem	small-molecule	Agonist	noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, dopamine, 5-hydroxytryptamine	small-molecule	Zhuang Y, Xu P, Mao C, Wang L, Krumm B, Zhou XE, Huang S, Liu H, Cheng X, Huang XP, Shen DD, Xu T, Liu YF, Wang Y, Guo J, Jiang Y, Jiang H, Melcher K, Roth BL, Zhang Y, Zhang C, Xu HE	10.1016/J.CELL.2021.01.027	2021-02-24	56198
Gs	αs	Human	Engineered G alpha	58	β1	Human	γ2	Human	Cryo-EM	7L1U	-	3.2	OX2R	OX₂	Orexin	A (Rhodopsin)	Human	-	scFv16	-	Orexin-A pubchem	peptide	Agonist	orexin-B, orexin-A	peptide	Hong C, Byrne NJ, Zamlynny B, Tummala S, Xiao L, Shipman JM, Partridge AT, Minnick C, Breslin MJ, Rudd MT, Stachel SJ, Rada VL, Kern JC, Armacost KA, Hollingsworth SA, O'Brien JA, Hall DL, McDonald TP, Strickland C, Brooun A, Soisson SM, Hollenstein K	10.1038/S41467-021-21087-6	2021-02-10	56198
Gs	αs	Human	Engineered G alpha	58	β1	Human	γ2	Human	Cryo-EM	7L1V	-	3.0	OX2R	OX₂	Orexin	A (Rhodopsin)	Human	-	scFv16 Nanobody-51	-	compound 1 [PMID: 33547286] pubchem gtoplig chembl_ligand	small-molecule	Agonist	orexin-B, orexin-A	peptide	Hong C, Byrne NJ, Zamlynny B, Tummala S, Xiao L, Shipman JM, Partridge AT, Minnick C, Breslin MJ, Rudd MT, Stachel SJ, Rada VL, Kern JC, Armacost KA, Hollingsworth SA, O'Brien JA, Hall DL, McDonald TP, Strickland C, Brooun A, Soisson SM, Hollenstein K	10.1038/S41467-021-21087-6	2021-02-10	56198
Gi/o	αo	Human	-	61	β1	Human	γ2	Human	Cryo-EM	7D77	-	2.9	AGRG3	ADGRG3	ADGRG	B2 (Adhesion)	Human	-	scFv16	-	HYDROCORTISONE chembl_ligand pubchem	small-molecule	Agonist	-	-	Ping YQ, Mao C, Xiao P, Zhao RJ, Jiang Y, Yang Z, An WT, Shen DD, Yang F, Zhang H, Qu C, Shen Q, Tian C, Li ZJ, Li S, Wang GY, Tao X, Wen X, Zhong YN, Yang J, Yi F, Yu X, Xu HE, Zhang Y, Sun JP	10.1038/S41586-020-03083-W	2021-02-03	56206
Gi/o	αo	Human	-	61	β1	Human	γ2	Human	Cryo-EM	7D76	-	3.1	AGRG3	ADGRG3	ADGRG	B2 (Adhesion)	Human	-	-	-	Beclomethasone pubchem	small-molecule	Agonist	-	-	Ping YQ, Mao C, Xiao P, Zhao RJ, Jiang Y, Yang Z, An WT, Shen DD, Yang F, Zhang H, Qu C, Shen Q, Tian C, Li ZJ, Li S, Wang GY, Tao X, Wen X, Zhong YN, Yang J, Yi F, Yu X, Xu HE, Zhang Y, Sun JP	10.1038/S41586-020-03083-W	2021-02-03	56206
Gs	αs	Human	-	62	β1	Human	γ2	Human	Cryo-EM	7LCI	7LCI_refined	2.9	GLP1R	GLP-1	Glucagon	B1 (Secretin)	Human	-	-	-	danuglipron pubchem gtoplig chembl_ligand pubchem	small-molecule	Agonist	glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37)	peptide	-	-	2021-01-20	56198
Gi/o	αi1	Human	-	95	β1	Human	γT1	Human	Cryo-EM	7L0Q	-	4.3	NTR1	NTS₁	Neurotensin	A (Rhodopsin)	Rat	-	-	-	neurotensin pubchem gtoplig chembl_ligand gtoplig gtoplig	peptide	Agonist	neurotensin, neuromedin N	peptide	Zhang M, Gui M, Wang ZF, Gorgulla C, Yu JJ, Wu H, Sun ZJ, Klenk C, Merklinger L, Morstein L, Hagn F, Pluckthun A, Brown A, Nasr ML, Wagner G	10.1038/S41594-020-00554-6	2021-01-06	56200
Gi/o	αi1	Human	Non-canonical conformation	63	β1	Human	γT1	Human	Cryo-EM	7L0R	-	4.2	NTR1	NTS₁	Neurotensin	A (Rhodopsin)	Rat	-	-	-	neurotensin pubchem gtoplig chembl_ligand gtoplig gtoplig	peptide	Agonist	neurotensin, neuromedin N	peptide	Zhang M, Gui M, Wang ZF, Gorgulla C, Yu JJ, Wu H, Sun ZJ, Klenk C, Merklinger L, Morstein L, Hagn F, Pluckthun A, Brown A, Nasr ML, Wagner G	10.1038/S41594-020-00554-6	2021-01-06	56200
Gi/o	αi1	Human	Non-canonical conformation	95	β1	Human	γT1	Human	Cryo-EM	7L0S	-	4.5	NTR1	NTS₁	Neurotensin	A (Rhodopsin)	Rat	-	-	-	neurotensin pubchem gtoplig chembl_ligand gtoplig gtoplig	peptide	Agonist	neurotensin, neuromedin N	peptide	Zhang M, Gui M, Wang ZF, Gorgulla C, Yu JJ, Wu H, Sun ZJ, Klenk C, Merklinger L, Morstein L, Hagn F, Pluckthun A, Brown A, Nasr ML, Wagner G	10.1038/S41594-020-00554-6	2021-01-06	56200
Gi/o	αi1	Human	-	63	β1	Human	γT1	Human	Cryo-EM	7L0P	-	4.1	NTR1	NTS₁	Neurotensin	A (Rhodopsin)	Rat	-	-	-	neurotensin pubchem gtoplig chembl_ligand gtoplig gtoplig	peptide	Agonist	neurotensin, neuromedin N	peptide	Zhang M, Gui M, Wang ZF, Gorgulla C, Yu JJ, Wu H, Sun ZJ, Klenk C, Merklinger L, Morstein L, Hagn F, Pluckthun A, Brown A, Nasr ML, Wagner G	10.1038/S41594-020-00554-6	2021-01-06	56200
Gs	αs	Human	-	49	β1	Bovine	γ2	Bovine	Cryo-EM	7DHR	7DHR_refined	3.8	ADRB2	β₂	Adrenoceptors	A (Rhodopsin)	Human	-	Nanobody-35	-	LEVISOPRENALINE chembl_ligand chembl_ligand pubchem	small-molecule	Agonist	Zn²⁺, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline	small-molecule	-	-	2020-12-16	56198
Gs	αs	Human	-	55	β1	Bovine	γ2	Bovine	Cryo-EM	7DHI	-	3.3	ADRB2	β₂	Adrenoceptors	A (Rhodopsin)	Human	-	Nanobody-35	-	levosalbutamol pubchem gtoplig chembl_ligand drug_central drugbank pubchem	small-molecule	Agonist	Zn²⁺, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline	small-molecule	Yang F, Ling S, Zhou Y, Zhang Y, Lv P, Liu S, Fang W, Sun W, Hu LA, Zhang L, Shi P, Tian C	10.1093/NSR/NWAA284	2020-12-16	56198
Gs	αs	Bovine	-	57	β1	Bovine	γ2	Bovine	Cryo-EM	7D68	-	3.0	GLP2R	GLP-2	Glucagon	B1 (Secretin)	Human	-	Nanobody-35	-	glucagon pubchem gtoplig chembl_ligand drugbank drug_central gtoplig pubchem pubchem pubchem pubchem pubchem	peptide	Agonist	glucagon-like peptide 2-(3-33), glucagon-like peptide 2	peptide	Sun W, Chen LN, Zhou Q, Zhao LH, Yang D, Zhang H, Cong Z, Shen DD, Zhao F, Zhou F, Cai X, Chen Y, Zhou Y, Gadgaard S, van der Velden WJC, Zhao S, Jiang Y, Rosenkilde MM, Xu HE, Zhang Y, Wang MW	10.1038/S41422-020-00442-0	2020-12-16	56215
GPa1 family	αPa1	strain ATCC 204508 / S288c	Two alpha subunits bound to STE2 dimer	46	STE4	strain ATCC 204508 / S288c	γ	strain ATCC 204508 / S288c	Cryo-EM	7AD3	-	3.5	STE2	STE2	STE2	D1 (Ste2-like fungal pheromone)	strain ATCC 204508 / S288c	-	-	-	Alpha-factor mating pheromone pubchem	peptide	Agonist	-	-	Velazhahan V, Ma N, Pandy-Szekeres G, Kooistra AJ, Lee Y, Gloriam DE, Vaidehi N, Tate CG	10.1038/S41586-020-2994-1	2020-12-09	56214
Gs	αs	Human	-	58	β1	Human	γ2	Human	Cryo-EM	7D7M	7D7M_refined	3.3	PE2R4	EP₄	Prostanoid	A (Rhodopsin)	Human	-	Nanobody-35	-	PGE₂ pubchem gtoplig chembl_ligand drugbank drug_central gtoplig pubchem	small-molecule	Agonist	PGE₁, PGF_2α, PGI₂, PGE₂, thromboxane A₂, PGD₂	small-molecule	Nojima S, Fujita Y, Kimura KT, Nomura N, Suno R, Morimoto K, Yamamoto M, Noda T, Iwata S, Shigematsu H, Kobayashi T	10.1016/J.STR.2020.11.007	2020-11-18	56198
Gs	αs	Human	-	58	β1	Rat	γ2	Bovine	Cryo-EM	7CZ5	7CZ5_refined	2.6	GHRHR	GHRH	Glucagon	B1 (Secretin)	Human	-	Nanobody-35	-	Somatoliberin pubchem	peptide	Agonist	GHRH	peptide	Zhou F, Zhang H, Cong Z, Zhao LH, Zhou Q, Mao C, Cheng X, Shen DD, Cai X, Ma C, Wang Y, Dai A, Zhou Y, Sun W, Zhao F, Zhao S, Jiang H, Jiang Y, Yang D, Eric Xu H, Zhang Y, Wang MW	10.1038/S41467-020-18945-0	2020-11-18	56198
Gs	αs	Human	-	56	β1	Human	γ2	Human	Cryo-EM	6XOX	-	3.1	GLP1R	GLP-1	Glucagon	B1 (Secretin)	Human	-	scFv16 Nanobody-35	-	orforglipron pubchem gtoplig chembl_ligand drugbank pubchem	small-molecule	Agonist	glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37)	peptide	Kawai T, Sun B, Yoshino H, Feng D, Suzuki Y, Fukazawa M, Nagao S, Wainscott DB, Showalter AD, Droz BA, Kobilka TS, Coghlan MP, Willard FS, Kawabe Y, Kobilka BK, Sloop KW	10.1073/PNAS.2014879117	2020-11-18	56198
Gs	αs	Human	-	58	β1	Rat	γ2	Bovine	Cryo-EM	7D3S	7D3S_refined	2.9	SCTR	secretin	Glucagon	B1 (Secretin)	Human	-	Nanobody-35	-	SECRETIN chembl_ligand pubchem drugbank pubchem	protein	Agonist	secretin, VIP	peptide	Fukuhara S, Kobayashi K, Kusakizako T, Iida W, Kato M, Shihoya W, Nureki O	10.1016/J.BBRC.2020.08.042	2020-11-04	56198
Gi/o	αt1	Bovine	-	100	-	-	-	-	Cryo-EM	7JSN	-	3.2	-	-	-	-	-	-	-	Rod cGMP-specific 3' 5'-cyclic phosphodiesterase subunit alpha Rod cGMP-specific 3' 5'-cyclic phosphodiesterase subunit beta	-	-	-	-	-	Gao Y, Eskici G, Ramachandran S, Poitevin F, Seven AB, Panova O, Skiniotis G, Cerione RA	33007200	2020-10-21	56310
Gi/o	αi1	Human	-	61	β1	Human	γ2	Human	Cryo-EM	6XBK	-	3.2	SMO	SMO	Frizzled	F (Frizzled)	Human	-	scFv16	-	Cholesterol pubchem	small-molecule	Agonist	-	-	Qi X, Friedberg L, De Bose-Boyd R, Long T, Li X	10.1038/S41589-020-0646-2	2020-09-30	56200
Gi/o	αi1	Human	-	61	β1	Human	γ2	Human	Cryo-EM	6XBM	-	3.2	SMO	SMO	Frizzled	F (Frizzled)	Human	-	scFv16	-	24,25-Epoxy-cholesterol pubchem 24,25-Epoxy-cholesterol pubchem	small-molecule small-molecule	Agonist PAM	-	-	Qi X, Friedberg L, De Bose-Boyd R, Long T, Li X	10.1038/S41589-020-0646-2	2020-09-30	56200
Gi/o	αi1	Human	-	61	β1	Human	γ2	Human	Cryo-EM	6XBJ	-	3.9	SMO	SMO	Frizzled	F (Frizzled)	Human	-	scFv16	-	Cholesterol pubchem	small-molecule	Agonist	-	-	-	-	2020-09-30	56200
Gi/o	αi1	Human	-	61	β1	Human	γ2	Human	Cryo-EM	6XBL	-	3.9	SMO	SMO	Frizzled	F (Frizzled)	Human	-	scFv16	-	Cholesterol pubchem SAG1.3 pubchem gtoplig chembl_ligand	small-molecule small-molecule	Agonist PAM	-	-	Qi X, Friedberg L, De Bose-Boyd R, Long T, Li X	10.1038/S41589-020-0646-2	2020-09-30	56200
Gq/11	αq	Human	Gq-Gi2-Gs chimera	57	β1	Human	γ2	Human	Cryo-EM	6WHA	-	3.4	5HT2A	5-HT_2A	5-Hydroxytryptamine	A (Rhodopsin)	Human	BRIL	scFv16	-	CHEMBL5184791 chembl_ligand pubchem	small-molecule	Agonist	tryptamine, 5-hydroxytryptamine	small-molecule	Kim K, Che T, Panova O, DiBerto JF, Lyu J, Krumm BE, Wacker D, Robertson MJ, Seven AB, Nichols DE, Shoichet BK, Skiniotis G, Roth BL	10.1016/J.CELL.2020.08.024	2020-09-23	56208
Gs	αs	Human	-	89	β1	Human	γ2	Human	Cryo-EM	6X1A	-	2.5	GLP1R	GLP-1	Glucagon	B1 (Secretin)	Human	-	Nanobody-35	-	danuglipron pubchem gtoplig chembl_ligand pubchem	small-molecule	Agonist	glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37)	peptide	Zhang X, Belousoff MJ, Zhao P, Kooistra AJ, Truong TT, Ang SY, Underwood CR, Egebjerg T, Senel P, Stewart GD, Liang YL, Glukhova A, Venugopal H, Christopoulos A, Furness SGB, Miller LJ, Reedtz-Runge S, Langmead CJ, Gloriam DE, Danev R, Sexton PM, Wootten D	10.1016/J.MOLCEL.2020.09.020	2020-09-09	56198
Gs	αs	Human	-	90	β1	Human	γ2	Human	Cryo-EM	6X18	-	2.1	GLP1R	GLP-1	Glucagon	B1 (Secretin)	Human	-	Nanobody-35	-	CHEMBL410972 chembl_ligand pubchem pubchem	protein	Agonist	glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37)	peptide	Zhang X, Belousoff MJ, Zhao P, Kooistra AJ, Truong TT, Ang SY, Underwood CR, Egebjerg T, Senel P, Stewart GD, Liang YL, Glukhova A, Venugopal H, Christopoulos A, Furness SGB, Miller LJ, Reedtz-Runge S, Langmead CJ, Gloriam DE, Danev R, Sexton PM, Wootten D	10.1016/J.MOLCEL.2020.09.020	2020-09-09	56198
Gs	αs	Human	-	58	β1	Human	γ2	Human	Cryo-EM	7CFM	-	3.0	GPBAR	GPBA	Bile acid	A (Rhodopsin)	Human	-	Nanobody-35	-	CHEMBL2331646 chembl_ligand pubchem	small-molecule	Agonist	lithocholic acid, deoxycholic acid, cholic acid, chenodeoxycholic acid	small-molecule	Yang F, Mao C, Guo L, Lin J, Ming Q, Xiao P, Wu X, Shen Q, Guo S, Shen DD, Lu R, Zhang L, Huang S, Ping Y, Zhang C, Ma C, Zhang K, Liang X, Shen Y, Nan F, Yi F, Luca VC, Zhou J, Jiang C, Sun JP, Xie X, Yu X, Zhang Y	10.1038/S41586-020-2569-1	2020-09-09	56198
Gs	αs	Human	-	89	β1	Human	γ2	Human	Cryo-EM	6X19	-	2.1	GLP1R	GLP-1	Glucagon	B1 (Secretin)	Human	-	Nanobody-35	-	CHU-128 pubchem	small-molecule	Agonist	glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37)	peptide	Zhang X, Belousoff MJ, Zhao P, Kooistra AJ, Truong TT, Ang SY, Underwood CR, Egebjerg T, Senel P, Stewart GD, Liang YL, Glukhova A, Venugopal H, Christopoulos A, Furness SGB, Miller LJ, Reedtz-Runge S, Langmead CJ, Gloriam DE, Danev R, Sexton PM, Wootten D	10.1016/J.MOLCEL.2020.09.020	2020-09-09	56198
Gs	αs	Human	-	59	β1	Human	γ2	Human	Cryo-EM	7CFN	7CFN_refined	3.0	GPBAR	GPBA	Bile acid	A (Rhodopsin)	Human	-	Nanobody-35	-	INT-777 pubchem INT-777 pubchem	small-molecule small-molecule	Agonist PAM	lithocholic acid, deoxycholic acid, cholic acid, chenodeoxycholic acid	small-molecule	Yang F, Mao C, Guo L, Lin J, Ming Q, Xiao P, Wu X, Shen Q, Guo S, Shen DD, Lu R, Zhang L, Huang S, Ping Y, Zhang C, Ma C, Zhang K, Liang X, Shen Y, Nan F, Yi F, Luca VC, Zhou J, Jiang C, Sun JP, Xie X, Yu X, Zhang Y	10.1038/S41586-020-2569-1	2020-09-09	56198
Gi/o	αi1	Human	-	65	β1	Human	γ2	Human	Cryo-EM	6LFO	6LFO_refined	3.4	CXCR2	CXCR2	Chemokine	A (Rhodopsin)	Human	-	scFv16	-	Interleukin-8 pubchem	protein	Agonist	CXCL3, CXCL6, CXCL7, CXCL1, CXCL8, CXCL2, CXCL5	peptide	Liu K, Wu L, Yuan S, Wu M, Xu Y, Sun Q, Li S, Zhao S, Hua T, Liu ZJ	10.1038/S41586-020-2492-5	2020-09-02	56200
Gi/o	αi1	Human	-	65	β1	Human	γ2	Human	Cryo-EM	6LFM	6LFM_refined	3.5	CXCR2	CXCR2	Chemokine	A (Rhodopsin)	Human	-	scFv16	-	Interleukin-8 pubchem	protein	Agonist	CXCL3, CXCL6, CXCL7, CXCL1, CXCL8, CXCL2, CXCL5	peptide	Liu K, Wu L, Yuan S, Wu M, Xu Y, Sun Q, Li S, Zhao S, Hua T, Liu ZJ	10.1038/S41586-020-2492-5	2020-09-02	56200
Gs	αs	Bovine	-	51	β1	Bovine	γ2	Bovine	Cryo-EM	7JJO	-	2.6	ADRB1	β₁	Adrenoceptors	A (Rhodopsin)	Wild turkey	-	Nanobody-35	-	LEVISOPRENALINE chembl_ligand chembl_ligand pubchem	small-molecule	Agonist	-	-	Su M, Zhu L, Zhang Y, Paknejad N, Dey R, Huang J, Lee MY, Williams D, Jordan KD, Eng ET, Ernst OP, Meyerson JR, Hite RK, Walz T, Liu W, Huang XY	10.1016/J.MOLCEL.2020.08.001	2020-09-02	56215
Gs	αs	Human	-	61	β1	Human	γ2	Human	Cryo-EM	6VN7	6VN7_refined	3.2	VIPR1	VPAC₁	VIP and PACAP	B1 (Secretin)	Human	-	Nanobody-35	-	[Ac-His¹]PACAP-27 gtoplig chembl_ligand pubchem	peptide	Agonist	secretin, PHM, PACAP-27, VIP, PACAP-38, PHI, GHRH	peptide	Duan J, Shen DD, Zhou XE, Bi P, Liu QF, Tan YX, Zhuang YW, Zhang HB, Xu PY, Huang SJ, Ma SS, He XH, Melcher K, Zhang Y, Xu HE, Jiang Y	10.1038/S41467-020-17933-8	2020-09-02	56198
Gs	αs	Human	-	57	β1	Rat	γ2	Bovine	Cryo-EM	7BW0	7BW0_refined	3.9	GPBAR	GPBA	Bile acid	A (Rhodopsin)	Human	BRIL	Nanobody-35	-	-	-	-	lithocholic acid, deoxycholic acid, cholic acid, chenodeoxycholic acid	small-molecule	Chen G, Wang X, Ge Y, Ma L, Chen Q, Liu H, Du Y, Ye RD, Hu H, Ren R	10.1038/S41392-020-00262-Z	2020-09-02	56198
Gs	αs	Human	-	49	β1	Human	γ2	Human	Cryo-EM	7C2E	-	4.2	GLP1R	GLP-1	Glucagon	B1 (Secretin)	Human	-	Nanobody-35	-	2-[[4-[6-[(4-cyano-2-fluoranyl-phenyl)methoxy]pyridin-2-yl]-3,6-dihydro-2~{H}-pyridin-1-yl]methyl]-3-[[(2~{S})-oxetan-2-yl]methyl]imidazo[4,5-b]pyridine-5-carboxylic acid pubchem	small-molecule	Agonist	glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37)	peptide	Ma H, Huang W, Wang X, Zhao L, Jiang Y, Liu F, Guo W, Sun X, Zhong W, Yuan D, Xu HE	10.1038/S41422-020-0384-8	2020-08-26	56198
Gs	αs	Human	-	56	β1	Human	γ2	Human	Cryo-EM	6WPW	6WPW_refined	3.1	GLR	glucagon	Glucagon	B1 (Secretin)	Human	-	Nanobody-35	-	Glucagon derivative ZP3780	peptide	Agonist	glucagon	peptide	Hilger D, Kumar KK, Hu H, Pedersen MF, O'Brien ES, Giehm L, Jennings C, Eskici G, Inoue A, Lerch M, Mathiesen JM, Skiniotis G, Kobilka BK	10.1126/SCIENCE.ABA3373	2020-08-12	56198
Gs	αs	Human	-	49	β1	Human	γ2	Human	Cryo-EM	6WI9	6WI9_refined	4.3	SCTR	secretin	Glucagon	B1 (Secretin)	Human	-	Nanobody-35	-	SECRETIN chembl_ligand pubchem drugbank pubchem	protein	Agonist	secretin, VIP	peptide	Dong M, Deganutti G, Piper SJ, Liang YL, Khoshouei M, Belousoff MJ, Harikumar KG, Reynolds CA, Glukhova A, Furness SGB, Christopoulos A, Danev R, Wootten D, Sexton PM, Miller LJ	10.1038/S41467-020-17791-4	2020-08-12	56198
Gs	αs	Human	-	61	β1	Human	γ2	Human	Cryo-EM	6WZG	6WZG_refined	2.3	SCTR	secretin	Glucagon	B1 (Secretin)	Human	-	Nanobody-35	-	SECRETIN chembl_ligand pubchem drugbank pubchem	protein	Agonist	secretin, VIP	peptide	Dong M, Deganutti G, Piper SJ, Liang YL, Khoshouei M, Belousoff MJ, Harikumar KG, Reynolds CA, Glukhova A, Furness SGB, Christopoulos A, Danev R, Wootten D, Sexton PM, Miller LJ	10.1038/S41467-020-17791-4	2020-08-12	56198
Gs	αs	Human	-	50	β1	Bovine	γ2	Bovine	Cryo-EM	7BZ2	7BZ2_refined	3.8	ADRB2	β₂	Adrenoceptors	A (Rhodopsin)	Human	-	Nanobody-35	-	ARFORMOTEROL chembl_ligand chembl_ligand chembl_ligand chembl_ligand pubchem drugbank drugbank pubchem	small-molecule	Agonist	Zn²⁺, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline	small-molecule	Zhang Y, Yang F, Ling S, Lv P, Zhou Y, Fang W, Sun W, Zhang L, Shi P, Tian C	10.1038/S41421-020-0176-9	2020-08-05	56198
Gs	αs	Human	-	57	β1	Human	γ2	Human	Cryo-EM	6VCB	-	3.3	GLP1R	GLP-1	Glucagon	B1 (Secretin)	Human	-	Nanobody-35	-	glucagon-like peptide 1-(7-37) pubchem gtoplig chembl_ligand gtoplig pubchem pubchem CHEMBL5197819 chembl_ligand pubchem	peptide small-molecule	Agonist PAM	glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37)	peptide	Bueno AB, Sun B, Willard FS, Feng D, Ho JD, Wainscott DB, Showalter AD, Vieth M, Chen Q, Stutsman C, Chau B, Ficorilli J, Agejas FJ, Cumming GR, Jimenez A, Rojo I, Kobilka TS, Kobilka BK, Sloop KW	10.1038/S41589-020-0589-7	2020-07-22	56198
Gi/o	αt2	Bovine	Only H5	3	-	-	-	-	X-ray	6PH7	6PH7_refined	2.9	OPSD	Rhodopsin	Opsins	A (Rhodopsin)	Bovine	-	-	-	Nerol pubchem	small-molecule	unknown	-	-	-	-	2020-07-01	56330
Gi/o	αt2	Bovine	Only H5	3	-	-	-	-	X-ray	6PGS	6PGS_refined	2.9	OPSD	Rhodopsin	Opsins	A (Rhodopsin)	Bovine	-	-	-	Geraniol pubchem	small-molecule	unknown	-	-	-	-	2020-07-01	56330
Gi/o	αt1	Bovine	Only H5	3	-	-	-	-	X-ray	6PEL	6PEL_refined	3.2	OPSD	Rhodopsin	Opsins	A (Rhodopsin)	Bovine	-	-	-	Citronellol pubchem	small-molecule	unknown	-	-	-	-	2020-06-24	56310
Gi/o	αo	Human	-	59	β1	Rat	γ2	Mouse	Cryo-EM	6WWZ	6WWZ_refined	3.3	CCR6	CCR6	Chemokine	A (Rhodopsin)	Human	-	scFv16	-	CCL20 gtoplig	peptide	Agonist	CCL20, beta-defensin 4A	peptide	Wasilko DJ, Johnson ZL, Ammirati M, Che Y, Griffor MC, Han S, Wu H	10.1038/S41467-020-16820-6	2020-06-24	56206
Gi/o	αi1	Human	-	64	β1	Human	γ2	Human	Cryo-EM	6VMS	-	3.8	DRD2	D₂	Dopamine	A (Rhodopsin)	Human	T4-Lysozyme	scFv16	-	bromocriptine pubchem gtoplig chembl_ligand drugbank drug_central pubchem	small-molecule	Agonist	dopamine	small-molecule	Yin J, Chen KM, Clark MJ, Hijazi M, Kumari P, Bai XC, Sunahara RK, Barth P, Rosenbaum DM	10.1038/S41586-020-2379-5	2020-06-17	56200
Gs	αs	Human	-	56	β1	Human	γ2	Human	Cryo-EM	6WHC	6WHC_refined	3.4	GLR	glucagon	Glucagon	B1 (Secretin)	Human	-	Nanobody-35	-	Dual-agonist peptide P15	peptide	Agonist	glucagon	peptide	Chang R, Zhang X, Qiao A, Dai A, Belousoff MJ, Tan Q, Shao L, Zhong L, Lin G, Liang YL, Ma L, Han S, Yang D, Danev R, Wang MW, Wootten D, Wu B, Sexton PM	10.1074/JBC.RA120.013793	2020-05-27	56198
Gi/o	αo	Human	-	60	β1	Mouse	γ2	Human	Cryo-EM	6K41	-	2.9	ADA2B	α_2B	Adrenoceptors	A (Rhodopsin)	Human	T4-Lysozyme	scFv	-	dexmedetomidine pubchem gtoplig chembl_ligand drugbank drug_central pubchem	small-molecule	Agonist	(-)-adrenaline, (-)-noradrenaline	small-molecule	Yuan D, Liu Z, Kaindl J, Maeda S, Zhao J, Sun X, Xu J, Gmeiner P, Wang HW, Kobilka BK	10.1038/S41589-020-0492-2	2020-04-15	56206
Gi/o	αi1	Human	-	62	β1	Mouse	γ2	Human	Cryo-EM	6K42	-	4.1	ADA2B	α_2B	Adrenoceptors	A (Rhodopsin)	Human	T4-Lysozyme	scFv	-	dexmedetomidine pubchem gtoplig chembl_ligand drugbank drug_central pubchem	small-molecule	Agonist	(-)-adrenaline, (-)-noradrenaline	small-molecule	-	-	2020-04-15	56200
Gi/o	αi1	Human	-	63	β1	Human	γ2	Human	Cryo-EM	6LML	6LML_refined	3.9	GLR	glucagon	Glucagon	B1 (Secretin)	Human	-	scFv16	-	glucagon pubchem gtoplig chembl_ligand drugbank drug_central gtoplig pubchem pubchem pubchem pubchem pubchem	peptide	Agonist	glucagon	peptide	Qiao A, Han S, Li X, Li Z, Zhao P, Dai A, Chang R, Tai L, Tan Q, Chu X, Ma L, Thorsen TS, Reedtz-Runge S, Yang D, Wang MW, Sexton PM, Wootten D, Sun F, Zhao Q, Wu B	10.1126/SCIENCE.AAZ5346	2020-04-01	56200
Gs	αs	Human	-	48	β1	Human	γ2	Human	Cryo-EM	6UUS	6UUS_refined	2.4	CALRL	calcitonin-like	Calcitonin	B1 (Secretin)	Human	-	Nanobody-35 RAMP3	-	Adrenomedullin pubchem	peptide	Agonist	-	-	Liang YL, Belousoff MJ, Fletcher MM, Zhang X, Khoshouei M, Deganutti G, Koole C, Furness SGB, Miller LJ, Hay DL, Christopoulos A, Reynolds CA, Danev R, Wootten D, Sexton PM	10.1021/ACSPTSCI.9B00080	2020-04-01	56198
Gs	αs	Human	-	48	β1	Human	γ2	Human	Cryo-EM	6UVA	-	2.3	CALRL	calcitonin-like	Calcitonin	B1 (Secretin)	Human	-	Nanobody-35 RAMP3	-	adrenomedullin 2/intermedin gtoplig	peptide	Agonist	-	-	Liang YL, Belousoff MJ, Fletcher MM, Zhang X, Khoshouei M, Deganutti G, Koole C, Furness SGB, Miller LJ, Hay DL, Christopoulos A, Reynolds CA, Danev R, Wootten D, Sexton PM	10.1021/ACSPTSCI.9B00080	2020-04-01	56198
Gs	αs	Human	-	59	β1	Human	γ2	Human	Cryo-EM	6LMK	6LMK_refined	3.7	GLR	glucagon	Glucagon	B1 (Secretin)	Human	-	Nanobody-35	-	glucagon pubchem gtoplig chembl_ligand drugbank drug_central gtoplig pubchem pubchem pubchem pubchem pubchem	peptide	Agonist	glucagon	peptide	Qiao A, Han S, Li X, Li Z, Zhao P, Dai A, Chang R, Tai L, Tan Q, Chu X, Ma L, Thorsen TS, Reedtz-Runge S, Yang D, Wang MW, Sexton PM, Wootten D, Sun F, Zhao Q, Wu B	10.1126/SCIENCE.AAZ5346	2020-04-01	56198
Gs	αs	Human	-	48	β1	Human	γ2	Human	Cryo-EM	6UUN	6UUN_refined	3.0	CALRL	calcitonin-like	Calcitonin	B1 (Secretin)	Human	-	Nanobody-35 RAMP2	-	Adrenomedullin pubchem	peptide	Agonist	-	-	Liang YL, Belousoff MJ, Fletcher MM, Zhang X, Khoshouei M, Deganutti G, Koole C, Furness SGB, Miller LJ, Hay DL, Christopoulos A, Reynolds CA, Danev R, Wootten D, Sexton PM	10.1021/ACSPTSCI.9B00080	2020-03-25	56198
Gi/o	αi1	Human	-	100	-	-	-	-	Cryo-EM	6VU8	-	4.1	-	-	-	-	-	-	-	Resistance to inhibitors of cholinesterase 8 homolog A (C. elegans)	-	-	-	-	-	Seven AB, Hilger D, Papasergi-Scott MM, Zhang L, Qu Q, Kobilka BK, Tall GG, Skiniotis G	32126208	2020-03-18	56200
Gq/11	αq	Human	-	100	-	-	-	-	Cryo-EM	6VU5	-	3.5	-	-	-	-	-	-	-	Resistance to inhibitors of cholinesterase-8A (Ric-8A)	-	-	-	-	-	Seven AB, Hilger D, Papasergi-Scott MM, Zhang L, Qu Q, Kobilka BK, Tall GG, Skiniotis G	32126208	2020-03-18	56208
Gi/o	αi1	Rat	-	100	-	-	-	-	X-ray	6TYL	-	3.3	-	-	-	-	-	-	Nanobody A Nanobody B Nanobody C	Resistance to inhibitors of cholinesterase 8 homolog A (C. elegans)	-	-	-	-	-	McClelland LJ, Zhang K, Mou TC, Johnston J, Yates-Hansen C, Li S, Thomas CJ, Doukov TI, Triest S, Wohlkonig A, Tall GG, Steyaert J, Chiu W, Sprang SR	32103024	2020-03-11	56260
Gi/o	αi1	Rat	-	91	-	-	-	-	Cryo-EM	6UKT	-	3.9	-	-	-	-	-	-	NB8109 NB8117 NB8119 NB9156	Resistance to inhibitors of cholinesterase 8 homolog A (C. elegans)	-	-	-	-	-	McClelland LJ, Zhang K, Mou TC, Johnston J, Yates-Hansen C, Li S, Thomas CJ, Doukov TI, Triest S, Wohlkonig A, Tall GG, Steyaert J, Chiu W, Sprang SR	32103024	2020-03-11	56260
Gs	αs	Human	-	55	β1	Human	γ2	Human	Cryo-EM	6M1H	-	3.6	PACR	PAC₁	VIP and PACAP	B1 (Secretin)	Human	-	Nanobody-35	-	maxadilan gtoplig pubchem	peptide	Agonist	PHM, PACAP-27, VIP, PHV, PACAP-38, PHI	peptide	Wang J, Song X, Zhang D, Chen X, Li X, Sun Y, Li C, Song Y, Ding Y, Ren R, Harrington EH, Hu LA, Zhong W, Xu C, Huang X, Wang HW, Ma Y	10.1038/S41422-020-0280-2	2020-03-11	56198
Gs	αs	Human	-	57	β1	Human	γ2	Human	Cryo-EM	6M1I	-	3.5	PACR	PAC₁	VIP and PACAP	B1 (Secretin)	Human	-	Nanobody-35	-	[Ac-His¹]PACAP-27 gtoplig chembl_ligand pubchem	peptide	Agonist	PHM, PACAP-27, VIP, PHV, PACAP-38, PHI	peptide	Wang J, Song X, Zhang D, Chen X, Li X, Sun Y, Li C, Song Y, Ding Y, Ren R, Harrington EH, Hu LA, Zhong W, Xu C, Huang X, Wang HW, Ma Y	10.1038/S41422-020-0280-2	2020-03-11	56198
Gs	αs	Human	-	57	β1	Rat	γ2	Bovine	Cryo-EM	6LPB	6LPB_refined	3.9	PACR	PAC₁	VIP and PACAP	B1 (Secretin)	Human	-	Nanobody-35	-	[Ac-His¹]PACAP-27 gtoplig chembl_ligand pubchem	peptide	Agonist	PHM, PACAP-27, VIP, PHV, PACAP-38, PHI	peptide	Kobayashi K, Shihoya W, Nishizawa T, Kadji FMN, Aoki J, Inoue A, Nureki O	10.1038/S41594-020-0386-8	2020-03-11	56198
Gi/o	αi1	Human	-	61	β1	Human	γ2	Human	Cryo-EM	6OMM	6OMM_refined	3.2	FPR2	FPR2/ALX	Formylpeptide	A (Rhodopsin)	Human	-	-	-	CHEMBL552527 chembl_ligand pubchem	protein	Agonist	PrP_106-126, aspirin triggered lipoxin A4, annexin I, LL-37, aspirin-triggered resolvin D1, serum amyloid A, resolvin D1, humanin, LXA₄	peptide	Zhuang Y, Liu H, Edward Zhou X, Kumar Verma R, de Waal PW, Jang W, Xu TH, Wang L, Meng X, Zhao G, Kang Y, Melcher K, Fan H, Lambert NA, Eric Xu H, Zhang C	10.1038/S41467-020-14728-9	2020-02-26	56200
Gs	αs	Human	Mini-Gs	61	β1	Human	γ2	Human	Cryo-EM	6LI3	-	3.3	GPR52	GPR52	A orphans	A (Rhodopsin)	Human	-	Nanobody-35	-	Apo (no ligand)	none	Apo (no ligand)	-	-	Lin X, Li M, Wang N, Wu Y, Luo Z, Guo S, Han GW, Li S, Yue Y, Wei X, Xie X, Chen Y, Zhao S, Wu J, Lei M, Xu F	10.1038/S41586-020-2019-0	2020-02-26	56198
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	6KPF	6KPF_refined	2.9	CNR2	CB₂	Cannabinoid	A (Rhodopsin)	Human	-	scFv16	-	AM12033 pubchem	small-molecule	Agonist	2-arachidonoylglycerol, anandamide	small-molecule	-	-	2020-02-12	56200
Gi/o	αt1	Bovine	Only H5	3	-	-	-	-	X-ray	6NWE	6NWE_refined	2.7	OPSD	Rhodopsin	Opsins	A (Rhodopsin)	Bovine	-	-	-	B-Octylglucoside pubchem	small-molecule	unknown	-	-	-	-	2020-02-12	56310
Gi/o	αi1	Human	-	100	β1	Human	γ2	Human	Cryo-EM	6PT0	6PT0_refined	3.2	CNR2	CB₂	Cannabinoid	A (Rhodopsin)	Human	-	scFv16	-	WIN55212-2 pubchem gtoplig chembl_ligand drugbank	small-molecule	Agonist	2-arachidonoylglycerol, anandamide	small-molecule	Xing C, Zhuang Y, Xu TH, Feng Z, Zhou XE, Chen M, Wang L, Meng X, Xue Y, Wang J, Liu H, McGuire TF, Zhao G, Melcher K, Zhang C, Xu HE, Xie XQ	10.1016/J.CELL.2020.01.007	2020-02-12	56200
Gi/o	αi1	Human	-	64	β1	Human	γ2	Human	Cryo-EM	6KPG	6KPG_refined	3.0	CNR1	CB₁	Cannabinoid	A (Rhodopsin)	Human	-	scFv16	-	AM841 pubchem gtoplig chembl_ligand	small-molecule	Agonist	2-arachidonoylglycerol, anandamide	small-molecule	-	-	2020-02-12	56200
Gs	αs	Human	Gs-Gi1 chimera	58	β1	Human	γ2	Human	Cryo-EM	6PB0	-	3.0	CRFR1	CRF₁	Corticotropin-releasing factor	B1 (Secretin)	Human	-	Nanobody-35	-	Urocortin pubchem	peptide	Agonist	urocortin 1, urocortin 2, corticotrophin-releasing hormone	peptide	Ma S, Shen Q, Zhao LH, Mao C, Zhou XE, Shen DD, de Waal PW, Bi P, Li C, Jiang Y, Wang MW, Sexton PM, Wootten D, Melcher K, Zhang Y, Xu HE	10.1016/J.MOLCEL.2020.01.013	2020-02-12	56198
Gs	αs	Human	-	58	β1	Human	γ2	Human	Cryo-EM	6PB1	6PB1_refined	2.8	CRFR2	CRF₂	Corticotropin-releasing factor	B1 (Secretin)	Human	-	Nanobody-35	-	Urocortin pubchem	peptide	Agonist	urocortin 1, urocortin 3, urocortin 2, corticotrophin-releasing hormone	peptide	Ma S, Shen Q, Zhao LH, Mao C, Zhou XE, Shen DD, de Waal PW, Bi P, Li C, Jiang Y, Wang MW, Sexton PM, Wootten D, Melcher K, Zhang Y, Xu HE	10.1016/J.MOLCEL.2020.01.013	2020-02-12	56198
Gs	αs	Human	-	49	β1	Human	γ2	Human	Cryo-EM	6P9X	-	2.9	CRFR1	CRF₁	Corticotropin-releasing factor	B1 (Secretin)	Human	-	Nanobody-35	-	Corticoliberin pubchem	peptide	Agonist	urocortin 1, urocortin 2, corticotrophin-releasing hormone	peptide	Liang YL, Belousoff MJ, Zhao P, Koole C, Fletcher MM, Truong TT, Julita V, Christopoulos G, Xu HE, Zhang Y, Khoshouei M, Christopoulos A, Danev R, Sexton PM, Wootten D	10.1016/J.MOLCEL.2020.01.012	2020-02-05	56198
Gs	αs	Human	-	49	β1	Human	γ2	Human	Cryo-EM	6P9Y	-	3.0	PACR	PAC₁	VIP and PACAP	B1 (Secretin)	Human	-	Nanobody-35	-	[Ac-His¹]PACAP-27 gtoplig chembl_ligand pubchem	peptide	Agonist	PHM, PACAP-27, VIP, PHV, PACAP-38, PHI	peptide	Liang YL, Belousoff MJ, Zhao P, Koole C, Fletcher MM, Truong TT, Julita V, Christopoulos G, Xu HE, Zhang Y, Khoshouei M, Christopoulos A, Danev R, Sexton PM, Wootten D	10.1016/J.MOLCEL.2020.01.012	2020-02-05	56198
Gs	αs	Human	-	49	β1	Human	γ2	Human	Cryo-EM	6ORV	6ORV_refined	3.0	GLP1R	GLP-1	Glucagon	B1 (Secretin)	Human	-	Nanobody-35	-	CHEMBL3950796 chembl_ligand pubchem	small-molecule	Agonist	glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37)	peptide	Zhao P, Liang YL, Belousoff MJ, Deganutti G, Fletcher MM, Willard FS, Bell MG, Christe ME, Sloop KW, Inoue A, Truong TT, Clydesdale L, Furness SGB, Christopoulos A, Wang MW, Miller LJ, Reynolds CA, Danev R, Sexton PM, Wootten D	10.1038/s41586-019-1902-z	2020-01-08	56198
Gs	αs	Human	-	59	β1	Human	γ2	Human	Cryo-EM	6NI3	6NI3_refined	3.8	ADRB2	β₂	Adrenoceptors	A (Rhodopsin)	Human	-	Nanobody-35	-	CHEMBL1615159 chembl_ligand pubchem	small-molecule	Agonist	Zn²⁺, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline	small-molecule	Nguyen AH, Thomsen ARB, Cahill TJ 3rd, Huang R, Huang LY, Marcink T, Clarke OB, Heissel S, Masoudi A, Ben-Hail D, Samaan F, Dandey VP, Tan YZ, Hong C, Mahoney JP, Triest S, Little J 4th, Chen X, Sunahara R, Steyaert J, Molina H, Yu Z, des Georges A, Lefkowitz RJ	10.1038/S41594-019-0330-Y	2019-11-20	56198
Gi/o	αi1	Rat	-	100	-	-	-	-	X-ray	6M8H	-	2.1	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	2019-08-21	56260
Gi/o	αi3	Rat	-	99	-	-	-	-	X-ray	6MHE	-	2.2	-	-	-	-	-	-	-	KB752 peptide	-	-	-	-	-	Kalogriopoulos NA, Rees SD, Ngo T, Kopcho NJ, Ilatovskiy AV, Sun N, Komives EA, Chang G, Ghosh P, Kufareva I	31363053	2019-07-31	56307
Gi/o	αi3	Rat	-	99	-	-	-	-	X-ray	6MHF	-	2.0	-	-	-	-	-	-	-	Girdin	-	-	-	-	-	Kalogriopoulos NA, Rees SD, Ngo T, Kopcho NJ, Ilatovskiy AV, Sun N, Komives EA, Chang G, Ghosh P, Kufareva I	31363053	2019-07-31	56307
Gi/o	αt1	Bovine	-	64	β1	Bovine	γT1	Bovine	Cryo-EM	6OY9	-	3.9	OPSD	Rhodopsin	Opsins	A (Rhodopsin)	Bovine	-	-	-	Retinal (all-trans) pubchem	small-molecule	Agonist	-	-	Gao Y, Hu H, Ramachandran S, Erickson JW, Cerione RA, Skiniotis G	10.1016/J.MOLCEL.2019.06.007	2019-07-24	56310
Gi/o	αt1	Bovine	-	59	β1	Bovine	γT1	Bovine	Cryo-EM	6OYA	-	3.3	OPSD	Rhodopsin	Opsins	A (Rhodopsin)	Bovine	-	Camelid antibody VHH fragment	-	Retinal (all-trans) pubchem	small-molecule	Agonist	-	-	Gao Y, Hu H, Ramachandran S, Erickson JW, Cerione RA, Skiniotis G	10.1016/J.MOLCEL.2019.06.007	2019-07-24	56310
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	6OS9	6OS9_refined	3.0	NTR1	NTS₁	Neurotensin	A (Rhodopsin)	Human	-	scFv16	-	JMV449 pubchem gtoplig chembl_ligand	peptide	Agonist	large neurotensin, neurotensin, neuromedin N, large neuromedin N	peptide	Kato HE, Zhang Y, Hu H, Suomivuori CM, Kadji FMN, Aoki J, Krishna Kumar K, Fonseca R, Hilger D, Huang W, Latorraca NR, Inoue A, Dror RO, Kobilka BK, Skiniotis G	10.1038/S41586-019-1337-6	2019-07-10	56200
Gi/o	αi1	Human	-	60	β1	Bovine	γT1	Bovine	Cryo-EM	6QNO	-	4.4	OPSD	Rhodopsin	Opsins	A (Rhodopsin)	Bovine	-	Fab antibody fragment light chain Fab antibody fragment heavy chain	-	Retinal (all-trans) pubchem	small-molecule	Agonist	-	-	Tsai CJ, Marino J, Adaixo R, Pamula F, Muehle J, Maeda S, Flock T, Taylor NM, Mohammed I, Matile H, Dawson RJ, Deupi X, Stahlberg H, Schertler G	10.7554/ELIFE.46041	2019-07-10	56200
Gi/o	αi1	Human	Non-canonical conformation	62	β1	Human	γ2	Human	Cryo-EM	6OSA	-	3.0	NTR1	NTS₁	Neurotensin	A (Rhodopsin)	Human	-	-	-	JMV449 pubchem gtoplig chembl_ligand	peptide	Agonist	large neurotensin, neurotensin, neuromedin N, large neuromedin N	peptide	Kato HE, Zhang Y, Hu H, Suomivuori CM, Kadji FMN, Aoki J, Krishna Kumar K, Fonseca R, Hilger D, Huang W, Latorraca NR, Inoue A, Dror RO, Kobilka BK, Skiniotis G	10.1038/S41586-019-1337-6	2019-07-10	56200
Gi/o	αt2	Human	-	100	-	-	-	-	X-ray	6N84	-	1.8	-	-	-	-	-	-	-	-	-	-	-	-	-	Srivastava D, Gakhar L, Artemyev NO	31300652	2019-07-10	56204
Gi/o	αt2	Human	-	100	-	-	-	-	X-ray	6N85	-	2.5	-	-	-	-	-	-	-	Synembryn-A	-	-	-	-	-	Srivastava D, Gakhar L, Artemyev NO	31300652	2019-07-10	56204
Gi/o	αi1	Human	-	100	β1	Human	γ2	Human	Cryo-EM	6OT0	-	3.9	SMO	SMO	Frizzled	F (Frizzled)	Human	-	Fab light chain Fab heavy chain	-	24,25-Epoxy-cholesterol pubchem	small-molecule	Agonist	-	-	Qi X, Liu H, Thompson B, McDonald J, Zhang C, Li X	10.1038/S41586-019-1286-0	2019-06-12	56200
Gs	αs	Human	Fused partial Gs	44	-	-	-	-	X-ray	6E67	6E67_refined	3.7	ADRB2	β₂	Adrenoceptors	A (Rhodopsin)	Human	T4-Lysozyme	-	-	CHEMBL1615159 chembl_ligand pubchem	small-molecule	Agonist	Zn²⁺, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline	small-molecule	Liu X, Xu X, Hilger D, Aschauer P, Tiemann JKS, Du Y, Liu H, Hirata K, Sun X, Guixa-Gonzalez R, Mathiesen JM, Hildebrand PW, Kobilka BK	10.1016/J.CELL.2019.04.021	2019-06-05	56198
Gs	αs2	Human	-	97	β1	Human	γ2	Human	X-ray	6EG8	-	2.8	-	-	-	-	-	-	-	-	-	-	-	-	-	Liu X, Xu X, Hilger D, Aschauer P, Tiemann JKS, Du Y, Liu H, Hirata K, Sun X, Guixa-Gonzalez R, Mathiesen JM, Hildebrand PW, Kobilka BK	31080070	2019-06-05	56198
Gi/o	αo	Human	-	61	β1	Human	γ2	Human	Cryo-EM	6OIK	6OIK_refined	3.6	ACM2	M₂	Acetylcholine (muscarinic)	A (Rhodopsin)	Human	-	-	-	LY2119620 pubchem gtoplig chembl_ligand iperoxo pubchem gtoplig chembl_ligand	small-molecule small-molecule	Ago-PAM Agonist	acetylcholine	small-molecule	Maeda S, Qu Q, Robertson MJ, Skiniotis G, Kobilka BK	10.1126/SCIENCE.AAW5188	2019-05-08	56206
Gq/11	α11	Human	-	63	β1	Human	γ2	Human	Cryo-EM	6OIJ	6OIJ_refined	3.3	ACM1	M₁	Acetylcholine (muscarinic)	A (Rhodopsin)	Human	-	Antibody fragment	-	iperoxo pubchem gtoplig chembl_ligand	small-molecule	Agonist	acetylcholine	small-molecule	Maeda S, Qu Q, Robertson MJ, Skiniotis G, Kobilka BK	10.1126/SCIENCE.AAW5188	2019-05-08	56209
Gs	αs2	Bovine	-	100	-	-	-	-	Cryo-EM	6R3Q	-	3.4	-	-	-	-	-	-	-	Adenylate cyclase 9	-	-	-	-	-	Qi C, Sorrentino S, Medalia O, Korkhov VM	31023924	2019-05-08	56215
Gs	αs2	Bovine	-	100	-	-	-	-	Cryo-EM	6R4O	-	4.2	-	-	-	-	-	-	-	Adenylate cyclase 9	-	-	-	-	-	Qi C, Sorrentino S, Medalia O, Korkhov VM	31023924	2019-05-08	56215
Gs	αs2	Bovine	-	100	-	-	-	-	Cryo-EM	6R4P	-	3.1	-	-	-	-	-	-	-	Adenylate cyclase 9	-	-	-	-	-	Qi C, Sorrentino S, Medalia O, Korkhov VM	31023924	2019-05-08	56215
Gs	αs	Bovine	-	57	β1	Rat	γ2	Bovine	Cryo-EM	6NBH	-	3.5	PTH1R	PTH1	Parathyroid hormone	B1 (Secretin)	Human	-	Nanobody-35	-	Long-acting parathyroid hormone analog	peptide	Agonist	PTH, PTHrP, TIP39, PTHrP-(1-36)	peptide	Zhao LH, Ma S, Sutkeviciute I, Shen DD, Zhou XE, de Waal PW, Li CY, Kang Y, Clark LJ, Jean-Alphonse FG, White AD, Yang D, Dai A, Cai X, Chen J, Li C, Jiang Y, Watanabe T, Gardella TJ, Melcher K, Wang MW, Vilardaga JP, Xu HE, Zhang Y	10.1126/SCIENCE.AAV7942	2019-04-17	56215
Gs	αs	Bovine	-	58	β1	Rat	γ2	Bovine	Cryo-EM	6NBF	-	3.0	PTH1R	PTH1	Parathyroid hormone	B1 (Secretin)	Human	-	Nanobody-35	-	Long-acting parathyroid hormone analog	peptide	Agonist	PTH, PTHrP, TIP39, PTHrP-(1-36)	peptide	Zhao LH, Ma S, Sutkeviciute I, Shen DD, Zhou XE, de Waal PW, Li CY, Kang Y, Clark LJ, Jean-Alphonse FG, White AD, Yang D, Dai A, Cai X, Chen J, Li C, Jiang Y, Watanabe T, Gardella TJ, Melcher K, Wang MW, Vilardaga JP, Xu HE, Zhang Y	10.1126/SCIENCE.AAV7942	2019-04-17	56215
Gs	αs	Bovine	-	56	β1	Rat	γ2	Bovine	Cryo-EM	6NBI	-	4.0	PTH1R	PTH1	Parathyroid hormone	B1 (Secretin)	Human	-	Nanobody-35	-	Long-acting parathyroid hormone analog	peptide	Agonist	PTH, PTHrP, TIP39, PTHrP-(1-36)	peptide	Zhao LH, Ma S, Sutkeviciute I, Shen DD, Zhou XE, de Waal PW, Li CY, Kang Y, Clark LJ, Jean-Alphonse FG, White AD, Yang D, Dai A, Cai X, Chen J, Li C, Jiang Y, Watanabe T, Gardella TJ, Melcher K, Wang MW, Vilardaga JP, Xu HE, Zhang Y	10.1126/SCIENCE.AAV7942	2019-04-17	56215
Gi/o	αi1	Human	-	62	β1	Human	γ2	Human	Cryo-EM	6N4B	6N4B_refined	3.0	CNR1	CB₁	Cannabinoid	A (Rhodopsin)	Human	-	scFv16	-	MDMB-Fubinaca pubchem gtoplig	small-molecule	Agonist	2-arachidonoylglycerol, anandamide	small-molecule	Krishna Kumar K, Shalev-Benami M, Robertson MJ, Hu H, Banister SD, Hollingsworth SA, Latorraca NR, Kato HE, Hilger D, Maeda S, Weis WI, Farrens DL, Dror RO, Malhotra SV, Kobilka BK, Skiniotis G	10.1016/J.CELL.2018.11.040	2019-01-30	56200
Gs	αs	Human	-	43	β1	Human	γ2	Human	Cryo-EM	6NIY	-	3.3	CALCR	CT	Calcitonin	B1 (Secretin)	Human	-	-	-	calcitonin (salmon synthetic) pubchem chembl_ligand pubchem pubchem	small-molecule	Agonist	adrenomedullin, calcitonin, β-CGRP, adrenomedullin 2/intermedin, α-CGRP, amylin	peptide	Dal Maso E, Glukhova A, Zhu Y, Garcia-Nafria J, Tate CG, Atanasio S, Reynolds CA, Ramirez-Aportela E, Carazo JM, Hick CA, Furness SGB, Hay DL, Liang YL, Miller LJ, Christopoulos A, Wang MW, Wootten D, Sexton PM	10.1021/ACSPTSCI.8B00056	2019-01-23	56198
Gi/o	αi1	Human	-	100	β1	Human	γ2	Human	X-ray	6CRK	-	2.0	-	-	-	-	-	-	single-chain Fv	-	-	-	-	-	-	Maeda S, Koehl A, Matile H, Hu H, Hilger D, Schertler GFX, Manglik A, Skiniotis G, Dawson RJP, Kobilka BK	30213947	2018-10-24	56200
Gi/o	αo	Human	Mini-Go	51	-	-	-	-	X-ray	6FUF	6FUF_refined	3.1	OPSD	Rhodopsin	Opsins	A (Rhodopsin)	Bovine	-	-	-	Retinal (all-trans) pubchem	small-molecule	Agonist	-	-	Tsai CJ, Pamula F, Nehme R, Muhle J, Weinert T, Flock T, Nogly P, Edwards PC, Carpenter B, Gruhl T, Ma P, Deupi X, Standfuss J, Tate CG, Schertler GFX	10.1126/SCIADV.AAT7052	2018-10-03	56206
Gs	αs	Human	-	48	β1	Human	γ2	Human	Cryo-EM	6E3Y	6E3Y_refined	3.3	CALRL	calcitonin-like	Calcitonin	B1 (Secretin)	Human	-	Nanobody-35 RAMP1	-	Calcitonin gene-related peptide 1 pubchem	peptide	Agonist	-	-	Liang YL, Khoshouei M, Deganutti G, Glukhova A, Koole C, Peat TS, Radjainia M, Plitzko JM, Baumeister W, Miller LJ, Hay DL, Christopoulos A, Reynolds CA, Wootten D, Sexton PM	10.1038/S41586-018-0535-Y	2018-09-19	56198
Gi/o	αi1	Human	-	100	β1	Rat	γ2	Bovine	Cryo-EM	6CMO	6CMO_refined	4.5	OPSD	Rhodopsin	Opsins	A (Rhodopsin)	Human	BRIL	Fab	-	Apo (no ligand)	none	Apo (no ligand)	-	-	Kang Y, Kuybeda O, de Waal PW, Mukherjee S, Van Eps N, Dutka P, Zhou XE, Bartesaghi A, Erramilli S, Morizumi T, Gu X, Yin Y, Liu P, Jiang Y, Meng X, Zhao G, Melcher K, Ernst OP, Kossiakoff AA, Subramaniam S, Xu HE	10.1038/S41586-018-0215-Y	2018-06-20	56200
Gi/o	αo	Human	-	59	β1	Human	γ2	Human	Cryo-EM	6G79	-	3.8	5HT1B	5-HT_1B	5-Hydroxytryptamine	A (Rhodopsin)	Human	-	-	-	donitriptan pubchem gtoplig chembl_ligand	small-molecule	Agonist	5-HT-moduline, tryptamine, 5-hydroxytryptamine	small-molecule	Garcia-Nafria J, Nehme R, Edwards PC, Tate CG	10.1038/S41586-018-0241-9	2018-06-20	56206
Gi/o	αi2	Human	-	59	β1	Human	γ2	Human	Cryo-EM	6D9H	6D9H_refined	3.6	AA1R	A₁	Adenosine	A (Rhodopsin)	Human	-	-	-	adenosine pubchem gtoplig chembl_ligand drugbank drug_central pubchem	small-molecule	Agonist	adenosine	small-molecule	Draper-Joyce CJ, Khoshouei M, Thal DM, Liang YL, Nguyen ATN, Furness SGB, Venugopal H, Baltos JA, Plitzko JM, Danev R, Baumeister W, May LT, Wootten D, Sexton PM, Glukhova A, Christopoulos A	10.1038/S41586-018-0236-6	2018-06-20	56201
Gi/o	αi1	Human	-	61	β1	Human	γ2	Human	Cryo-EM	6DDF	-	3.5	OPRM	μ	Opioid	A (Rhodopsin)	Mouse	-	-	-	DAMGO pubchem gtoplig chembl_ligand chembl_ligand	peptide	Agonist	-	-	Koehl A, Hu H, Maeda S, Zhang Y, Qu Q, Paggi JM, Latorraca NR, Hilger D, Dawson R, Matile H, Schertler GFX, Granier S, Weis WI, Dror RO, Manglik A, Skiniotis G, Kobilka BK	10.1038/S41586-018-0219-7	2018-06-13	56200
Gi/o	αi1	Human	-	61	β1	Human	γ2	Human	Cryo-EM	6DDE	-	3.5	OPRM	μ	Opioid	A (Rhodopsin)	Mouse	-	Antibody	-	DAMGO pubchem gtoplig chembl_ligand chembl_ligand	peptide	Agonist	-	-	Koehl A, Hu H, Maeda S, Zhang Y, Qu Q, Paggi JM, Latorraca NR, Hilger D, Dawson R, Matile H, Schertler GFX, Granier S, Weis WI, Dror RO, Manglik A, Skiniotis G, Kobilka BK	10.1038/S41586-018-0219-7	2018-06-13	56200
Gs	αs	Human	-	57	β1	Human	γ2	Human	Cryo-EM	6GDG	6GDG_refined	4.1	AA2AR	A_2A	Adenosine	A (Rhodopsin)	Human	TrxA	Nanobody-35	-	NECA pubchem gtoplig chembl_ligand gtoplig	small-molecule	Agonist	adenosine	small-molecule	Garcia-Nafria J, Lee Y, Bai X, Carpenter B, Tate CG	10.7554/ELIFE.35946	2018-05-16	56198
Gs	αs2	Human	-	96	-	-	-	-	X-ray	6AU6	-	1.7	-	-	-	-	-	-	-	-	-	-	-	-	-	Hu Q, Shokat KM	29628140	2018-05-09	56198
Gs	αs	Human	-	49	β1	Human	γ2	Human	Cryo-EM	6B3J	-	3.3	GLP1R	GLP-1	Glucagon	B1 (Secretin)	Human	-	-	-	Exendin-P5	peptide	Agonist	glucagon-like peptide 1-(7-36) amide, glucagon, glucagon-like peptide 1-(7-37)	peptide	Liang YL, Khoshouei M, Glukhova A, Furness SGB, Zhao P, Clydesdale L, Koole C, Truong TT, Thal DM, Lei S, Radjainia M, Danev R, Baumeister W, Wang MW, Miller LJ, Christopoulos A, Sexton PM, Wootten D	10.1038/NATURE25773	2018-02-21	56198
Gi/o	αt1	Bovine	Only H5	3	-	-	-	-	X-ray	5WKT	5WKT_refined	3.2	OPSD	Rhodopsin	Opsins	A (Rhodopsin)	Bovine	-	-	-	B-Octylglucoside pubchem	small-molecule	unknown	-	-	Broecker J, Morizumi T, Ou WL, Klingel V, Kuo A, Kissick DJ, Ishchenko A, Lee MY, Xu S, Makarov O, Cherezov V, Ogata CM, Ernst OP	10.1038/NPROT.2017.135	2017-12-13	56310
Gs	αs	Human	-	59	β1	Rat	γ2	Bovine	Cryo-EM	5VAI	-	4.1	G1SGD4	GLP-1	Glucagon	B1 (Secretin)	Rabbit	-	-	-	CHEMBL410972 chembl_ligand pubchem pubchem	protein	Agonist	-	-	Zhang Y, Sun B, Feng D, Hu H, Chu M, Qu Q, Tarrasch JT, Li S, Sun Kobilka T, Kobilka BK, Skiniotis G	10.1038/NATURE22394	2017-05-24	56198
Gs	αs	Human	-	47	β1	Human	γ2	Human	Cryo-EM	5UZ7	-	4.1	CALCR	CT	Calcitonin	B1 (Secretin)	Human	-	-	-	calcitonin (salmon synthetic) pubchem chembl_ligand pubchem pubchem	small-molecule	Agonist	adrenomedullin, calcitonin, β-CGRP, adrenomedullin 2/intermedin, α-CGRP, amylin	peptide	Liang YL, Khoshouei M, Radjainia M, Zhang Y, Glukhova A, Tarrasch J, Thal DM, Furness SGB, Christopoulos G, Coudrat T, Danev R, Baumeister W, Miller LJ, Christopoulos A, Kobilka BK, Wootten D, Skiniotis G, Sexton PM	10.1038/NATURE22327	2017-05-03	56198
Gi/o	αi1	Human	-	100	β1	Rat	γ2	Bovine	X-ray	5TDH	-	3.0	-	-	-	-	-	-	-	-	-	-	-	-	-	Liu P, Jia MZ, Zhou XE, De Waal PW, Dickson BM, Liu B, Hou L, Yin YT, Kang YY, Shi Y, Melcher K, Xu HE, Jiang Y	27498775	2016-11-09	56200
Gi/o	αgust	Bovine	Only H5	3	-	-	-	-	X-ray	5EN0	5EN0_refined	2.8	OPSD	Rhodopsin	Opsins	A (Rhodopsin)	Bovine	-	-	-	Retinal (all-trans) pubchem	small-molecule	Agonist	-	-	Singhal A, Guo Y, Matkovic M, Schertler G, Deupi X, Yan EC, Standfuss J	10.15252/EMBR.201642671	2016-08-10	56354
Gi/o	αi1	Rat	-	100	-	-	-	-	X-ray	5KDL	-	2.7	-	-	-	-	-	-	-	-	-	-	-	-	-	Kaya AI, Lokits AD, Gilbert JA, Iverson TM, Meiler J, Hamm HE	27462082	2016-08-03	56260
Gi/o	αi1	Rat	-	100	β1	Bovine	γT1	Bovine	X-ray	5KDO	-	1.9	-	-	-	-	-	-	-	-	-	-	-	-	-	Kaya AI, Lokits AD, Gilbert JA, Iverson TM, Meiler J, Hamm HE	27462082	2016-08-03	56260
Gs	αs	Human	Engineered G protein	50	-	-	-	-	X-ray	5G53	5G53_refined	3.4	AA2AR	A_2A	Adenosine	A (Rhodopsin)	Human	-	-	-	NECA pubchem gtoplig chembl_ligand gtoplig	small-molecule	Agonist	adenosine	small-molecule	Carpenter B, Nehme R, Warne T, Leslie AG, Tate CG	10.1038/NATURE18966	2016-08-03	56198
Gq/11	αq	Mouse	-	87	-	-	-	-	X-ray	5DO9	-	2.6	-	-	-	-	-	-	-	Regulator of G-protein signaling 8	-	-	-	-	-	Taylor VG, Bommarito PA, Tesmer JJ	26755720	2016-01-20	56422
Gi/o	αt1	Bovine	Only H5	3	-	-	-	-	X-ray	4X1H	4X1H_refined	2.3	OPSD	Rhodopsin	Opsins	A (Rhodopsin)	Bovine	-	-	-	B-Nonylglucoside pubchem	small-molecule	unknown	-	-	Blankenship E, Vahedi-Faridi A, Lodowski DT	10.1016/J.STR.2015.09.015	2015-11-04	56310
Gq/11	αq	Mouse	-	100	-	-	-	-	X-ray	4QJ3	-	3.0	-	-	-	-	-	-	-	1-phosphatidylinositol 4 5-bisphosphate phosphodiesterase beta-3	-	-	-	-	-	Lyon AM, Begley JA, Manett TD, Tesmer JJG	25435326	2014-10-22	56422
Gq/11	αq	Mouse	-	100	-	-	-	-	X-ray	4QJ4	-	3.3	-	-	-	-	-	-	-	1-phosphatidylinositol 4 5-bisphosphate phosphodiesterase beta-3	-	-	-	-	-	Lyon AM, Begley JA, Manett TD, Tesmer JJG	25435326	2014-10-22	56422
Gq/11	αq	Mouse	-	100	-	-	-	-	X-ray	4QJ5	-	3.4	-	-	-	-	-	-	-	1-phosphatidylinositol 4 5-bisphosphate phosphodiesterase beta-3	-	-	-	-	-	Lyon AM, Begley JA, Manett TD, Tesmer JJG	25435326	2014-10-22	56422
Gi/o	αi1	Rat	-	100	-	-	-	-	X-ray	4PAM	-	2.1	-	-	-	-	-	-	-	-	-	-	-	-	-	Kaya AI, Lokits AD, Gilbert JA, Iverson TM, Meiler J, Hamm HE	25037222	2014-07-30	56260
Gi/o	αi1	Rat	-	100	-	-	-	-	X-ray	4PAN	-	2.4	-	-	-	-	-	-	-	-	-	-	-	-	-	Kaya AI, Lokits AD, Gilbert JA, Iverson TM, Meiler J, Hamm HE	25037222	2014-07-30	56260
Gi/o	αi1	Rat	-	100	-	-	-	-	X-ray	4PAO	-	2.0	-	-	-	-	-	-	-	-	-	-	-	-	-	Kaya AI, Lokits AD, Gilbert JA, Iverson TM, Meiler J, Hamm HE	25037222	2014-07-30	56260
Gi/o	αi1	Rat	-	100	-	-	-	-	X-ray	4PAQ	-	2.0	-	-	-	-	-	-	-	-	-	-	-	-	-	Kaya AI, Lokits AD, Gilbert JA, Iverson TM, Meiler J, Hamm HE	25037222	2014-07-30	56260
Gi/o	αi1	Rat	-	100	-	-	-	-	X-ray	4N0D	-	1.6	-	-	-	-	-	-	-	-	-	-	-	-	-	Thaker TM, Sarwar M, Preininger AM, Hamm HE, Iverson TM	24596087	2014-03-12	56260
Gi/o	αi1	Rat	-	100	-	-	-	-	X-ray	4N0E	-	2.1	-	-	-	-	-	-	-	-	-	-	-	-	-	Thaker TM, Sarwar M, Preininger AM, Hamm HE, Iverson TM	24596087	2014-03-12	56260
Gi/o	αt1	Bovine	Only H5	3	-	-	-	-	X-ray	4J4Q	4J4Q_refined	2.7	OPSD	Rhodopsin	Opsins	A (Rhodopsin)	Bovine	-	-	-	B-Octylglucoside pubchem	small-molecule	unknown	-	-	Park JH, Morizumi T, Li Y, Hong JE, Pai EF, Hofmann KP, Choe HW, Ernst OP	10.1002/ANIE.201302374	2013-10-30	56310
Gi/o	αt1	Bovine	Only H5	3	-	-	-	-	X-ray	4BEY	4BEY_refined	2.9	OPSD	Rhodopsin	Opsins	A (Rhodopsin)	Bovine	-	-	-	Apo (no ligand)	none	Apo (no ligand)	-	-	Singhal A, Ostermaier MK, Vishnivetskiy SA, Panneels V, Homan KT, Tesmer JJ, Veprintsev D, Deupi X, Gurevich VV, Schertler GF, Standfuss J	10.1038/EMBOR.2013.44	2013-05-08	56310
Gq/11	αq	Mouse	-	98	-	-	-	-	X-ray	4GNK	-	4.0	-	-	-	-	-	-	-	1-phosphatidylinositol 4 5-bisphosphate phosphodiesterase beta-3	-	-	-	-	-	Lyon AM, Dutta S, Boguth CA, Skiniotis G, Tesmer JJ	23377541	2013-02-06	56422
Gq/11	αq	Mouse	-	97	-	-	-	-	X-ray	4EKC	-	7.4	-	-	-	-	-	-	-	Regulator of G-protein signaling 2	-	-	-	-	-	Nance MR, Kreutz B, Tesmer VM, Sterne-Marr R, Kozasa T, Tesmer JJ	23434405	2013-01-30	56422
Gq/11	αq	Mouse	-	97	-	-	-	-	X-ray	4EKD	-	2.7	-	-	-	-	-	-	-	Regulator of G-protein signaling 2	-	-	-	-	-	Nance MR, Kreutz B, Tesmer VM, Sterne-Marr R, Kozasa T, Tesmer JJ	23434405	2013-01-30	56422
Gi/o	αi1	Human	-	100	-	-	-	-	X-ray	3UMR	-	2.0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	2012-10-24	56200
Gi/o	αi1	Human	-	93	-	-	-	-	X-ray	4G5Q	-	2.9	-	-	-	-	-	-	-	G-protein-signaling modulator 2	-	-	-	-	-	Jia M, Li J, Zhu J, Wen W, Zhang M, Wang W	22952234	2012-09-05	56200
Gi/o	αi3	Human	-	93	-	-	-	-	X-ray	4G5O	-	2.9	-	-	-	-	-	-	-	G-protein-signaling modulator 2	-	-	-	-	-	Jia M, Li J, Zhu J, Wen W, Zhang M, Wang W	22952234	2012-09-05	56202
Gi/o	αi3	Human	-	93	-	-	-	-	X-ray	4G5R	-	3.5	-	-	-	-	-	-	-	G-protein-signaling modulator 2	-	-	-	-	-	Jia M, Li J, Zhu J, Wen W, Zhang M, Wang W	22952234	2012-09-05	56202
Gi/o	αi3	Human	-	93	-	-	-	-	X-ray	4G5S	-	3.6	-	-	-	-	-	-	-	G-protein-signaling modulator 2	-	-	-	-	-	Jia M, Li J, Zhu J, Wen W, Zhang M, Wang W	22952234	2012-09-05	56202
Gi/o	αi1	Rat	-	100	-	-	-	-	X-ray	3V00	-	2.9	-	-	-	-	-	-	-	-	-	-	-	-	-	Singh G, Ramachandran S, Cerione RA	22448927	2012-04-18	56260
Gi/o	αi1	Human	-	100	-	-	-	-	X-ray	3UMS	-	2.3	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	2012-02-08	56200
Gi/o	αi1	Human	-	93	-	-	-	-	X-ray	3QI2	-	2.8	-	-	-	-	-	-	-	Regulator of G-protein signaling 14	-	-	-	-	-	Bosch DE, Willard FS, Ramanujam R, Kimple AJ, Willard MD, Naqvi NI, Siderovski DP	22383884	2012-02-01	56200
Gi/o	αt1	Bovine	Only H5	3	-	-	-	-	X-ray	4A4M	4A4M_refined	3.3	OPSD	Rhodopsin	Opsins	A (Rhodopsin)	Bovine	-	-	-	Retinal (all-trans) pubchem	small-molecule	Agonist	-	-	Deupi X, Edwards P, Singhal A, Nickle B, Oprian D, Schertler G, Standfuss J	10.1073/PNAS.1114089108	2012-01-25	56310
Gi/o	αi1	Human	-	92	-	-	-	-	X-ray	3QE0	-	3.0	-	-	-	-	-	-	-	KB752 peptide	-	-	-	-	-	Bosch DE, Willard FS, Ramanujam R, Kimple AJ, Willard MD, Naqvi NI, Siderovski DP	22383884	2012-01-25	56200
Gs	αs	Bovine	-	89	β1	Rat	γ2	Bovine	X-ray	3SN6	-	3.2	ADRB2	β₂	Adrenoceptors	A (Rhodopsin)	Human	T4-Lysozyme	Antibody	-	CHEMBL1615159 chembl_ligand pubchem	small-molecule	Agonist	Zn²⁺, noradrenaline, L-NOREPINEPHRINE, (-)-noradrenaline, (-)-adrenaline	small-molecule	Rasmussen SG, DeVree BT, Zou Y, Kruse AC, Chung KY, Kobilka TS, Thian FS, Chae PS, Pardon E, Calinski D, Mathiesen JM, Shah ST, Lyons JA, Caffrey M, Gellman SH, Steyaert J, Skiniotis G, Weis WI, Sunahara RK, Kobilka BK	10.1038/NATURE10361	2011-07-20	56215
Gi/o	αi1	Human	-	92	-	-	-	-	X-ray	2XNS	-	3.4	-	-	-	-	-	-	-	Regulator of G-protein signaling 14	-	-	-	-	-	Sammond DW, Bosch DE, Butterfoss GL, Purbeck C, Machius M, Siderovski DP, Kuhlman B	21388199	2011-06-08	56200
Gi/o	αt1	Human	-	3	-	-	-	-	X-ray	3RBQ	-	2.0	-	-	-	-	-	-	-	Protein unc-119 homolog A	-	-	-	-	-	Zhang H, Constantine R, Vorobiev S, Chen Y, Seetharaman J, Huang YJ, Xiao R, Montelione GT, Gerstner CD, Davis MW, Inana G, Whitby FG, Jorgensen EM, Hill CP, Tong L, Baehr W	21642972	2011-06-08	56203
Gi/o	αt1	Bovine	Only H5	3	-	-	-	-	X-ray	2X72	2X72_refined	3.0	OPSD	Rhodopsin	Opsins	A (Rhodopsin)	Bovine	-	-	-	Retinal (all-trans) pubchem	small-molecule	Agonist	-	-	Standfuss J, Edwards PC, D'Antona A, Fransen M, Xie G, Oprian DD, Schertler GF	10.1038/NATURE09795	2011-03-16	56310
Gi/o	αt1	Bovine	Only H5	3	-	-	-	-	X-ray	3PQR	3PQR_refined	2.9	OPSD	Rhodopsin	Opsins	A (Rhodopsin)	Bovine	-	-	-	Retinal (all-trans) pubchem	small-molecule	Agonist	-	-	Choe HW, Kim YJ, Park JH, Morizumi T, Pai EF, Krauss N, Hofmann KP, Scheerer P, Ernst OP	10.1038/NATURE09789	2011-03-09	56310
G12/13	α13	Mouse	-	96	-	-	-	-	X-ray	3AB3	-	2.4	-	-	-	-	-	-	-	Rho guanine nucleotide exchange factor 1	-	-	-	-	-	Hajicek N, Kukimoto-Niino M, Mishima-Tsumagari C, Chow CR, Shirouzu M, Terada T, Patel M, Yokoyama S, Kozasa T	21507947	2010-12-29	56505
Gi/o	αi1	Human	-	93	-	-	-	-	X-ray	3ONW	-	2.4	-	-	-	-	-	-	-	Regulator of G-protein signaling 14	-	-	-	-	-	Bosch DE, Kimple AJ, Sammond DW, Muller RE, Miley MJ, Machius M, Kuhlman B, Willard FS, Siderovski DP	21115486	2010-11-24	56200
Gi/o	αi1	Rat	-	100	β1	Bovine	γ2	Bovine	X-ray	3AH8	-	2.9	-	-	-	-	-	-	-	YM-254890	-	-	-	-	-	Nishimura A, Kitano K, Takasaki J, Taniguchi M, Mizuno N, Tago K, Hakoshima T, Itoh H	20639466	2010-07-21	56260
Gs	αs2	Bovine	-	100	-	-	-	-	X-ray	3MAA	-	3.0	-	-	-	-	-	-	-	Adenylate cyclase type 5 Adenylate cyclase type 2	-	-	-	-	-	Mou TC, Masada N, Cooper DM, Sprang SR	19243146	2010-04-07	56215
Gs	αs2	Bovine	-	100	-	-	-	-	X-ray	3G82	-	3.1	-	-	-	-	-	-	-	Adenylate cyclase type 5 Adenylate cyclase type 2	-	-	-	-	-	-	-	2010-02-16	56215
Gi/o	αi1	Rat	-	100	-	-	-	-	X-ray	3FFA	-	2.3	-	-	-	-	-	-	-	-	-	-	-	-	-	Kapoor N, Menon ST, Chauhan R, Sachdev P, Sakmar TP	19703466	2009-10-06	56260
Gi/o	αi1	Rat	-	100	-	-	-	-	X-ray	3FFB	-	2.6	-	-	-	-	-	-	-	-	-	-	-	-	-	Kapoor N, Menon ST, Chauhan R, Sachdev P, Sakmar TP	19703466	2009-10-06	56260
Gi/o	αi1	Rat	-	100	-	-	-	-	X-ray	2ZJY	-	2.8	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	2009-03-24	56260
Gi/o	αi1	Rat	-	100	-	-	-	-	X-ray	2ZJZ	-	2.6	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	2009-03-24	56260
Gi/o	αi1	Rat	-	100	-	-	-	-	X-ray	3D7M	-	2.9	-	-	-	-	-	-	-	-	-	-	-	-	-	Preininger AM, Funk MA, Oldham WM, Meier SM, Johnston CA, Adhikary S, Kimple AJ, Siderovski DP, Hamm HE, Iverson TM	19222191	2009-03-03	56260
Gs	αs2	Bovine	-	100	-	-	-	-	X-ray	3C14	-	2.7	-	-	-	-	-	-	-	Adenylate cyclase type 5 Adenylate cyclase type 2	-	-	-	-	-	Mou TC, Masada N, Cooper DM, Sprang SR	19243146	2009-02-03	56215
Gs	αs2	Bovine	-	100	-	-	-	-	X-ray	3C15	-	2.8	-	-	-	-	-	-	-	Adenylate cyclase type 5 Adenylate cyclase type 2	-	-	-	-	-	Mou TC, Masada N, Cooper DM, Sprang SR	19243146	2009-02-03	56215
Gs	αs2	Bovine	-	100	-	-	-	-	X-ray	3C16	-	2.9	-	-	-	-	-	-	-	Adenylate cyclase type 5 Adenylate cyclase type 2	-	-	-	-	-	Mou TC, Masada N, Cooper DM, Sprang SR	19243146	2009-02-03	56215
Gi/o	αi3	Human	-	99	-	-	-	-	X-ray	2V4Z	-	2.8	-	-	-	-	-	-	-	REGULATOR OF G-PROTEIN SIGNALING 2	-	-	-	-	-	Kimple AJ, Soundararajan M, Hutsell SQ, Roos AK, Urban DJ, Setola V, Temple BR, Roth BL, Knapp S, Willard FS, Siderovski DP	19478087	2008-11-04	56202
G12/13	α13	Mouse	-	90	-	-	-	-	X-ray	3CX6	-	2.5	-	-	-	-	-	-	-	Rho guanine nucleotide exchange factor 11	-	-	-	-	-	Chen Z, Singer WD, Danesh SM, Sternweis PC, Sprang SR	18940608	2008-10-28	56505
G12/13	α13	Mouse	-	90	-	-	-	-	X-ray	3CX7	-	2.3	-	-	-	-	-	-	-	Glutamate Transporter Associated Protein 48	-	-	-	-	-	Chen Z, Singer WD, Danesh SM, Sternweis PC, Sprang SR	18940608	2008-10-28	56505
G12/13	α13	Mouse	-	90	-	-	-	-	X-ray	3CX8	-	2.0	-	-	-	-	-	-	-	Rho guanine nucleotide exchange factor 11	-	-	-	-	-	Chen Z, Singer WD, Danesh SM, Sternweis PC, Sprang SR	18940608	2008-10-28	56505
Gi/o	αt1	Bovine	Only H5	3	-	-	-	-	X-ray	3DQB	3DQB_refined	3.2	OPSD	Rhodopsin	Opsins	A (Rhodopsin)	Bovine	-	-	-	Apo (no ligand)	none	Apo (no ligand)	-	-	None	10.1038/NATURE07330	2008-09-23	56310
Gi/o	αo	Mouse	-	94	-	-	-	-	X-ray	3C7K	-	2.9	-	-	-	-	-	-	-	Regulator of G-protein signaling 16	-	-	-	-	-	Slep KC, Kercher MA, Wieland T, Chen CK, Simon MI, Sigler PB	18434540	2008-05-06	56385
Gi/o	αi1	Rat	-	100	-	-	-	-	X-ray	2RGN	-	3.5	-	-	-	-	-	-	-	Rho guanine nucleotide exchange factor 25 Transforming protein RhoA	-	-	-	-	-	Lutz S, Shankaranarayanan A, Coco C, Ridilla M, Nance MR, Vettel C, Baltus D, Evelyn CR, Neubig RR, Wieland T, Tesmer JJ	18096806	2008-01-15	56260
Gi/o	αi1	Human	-	92	-	-	-	-	X-ray	2OM2	-	2.2	-	-	-	-	-	-	-	Regulator of G-protein signalling 14 GoLoco motif peptide	-	-	-	-	-	Sammond DW, Eletr ZM, Purbeck C, Kimple RJ, Siderovski DP, Kuhlman B	17603074	2007-07-10	56200
Gi/o	αi3	Human	-	99	-	-	-	-	X-ray	2ODE	-	1.9	-	-	-	-	-	-	-	Regulator of G-protein signaling 8	-	-	-	-	-	Soundararajan M, Willard FS, Kimple AJ, Turnbull AP, Ball LJ, Schoch GA, Gileadi C, Fedorov OY, Dowler EF, Higman VA, Hutsell SQ, Sundstrom M, Doyle DA, Siderovski DP	18434541	2007-02-06	56202
Gi/o	αi1	Human	-	92	-	-	-	-	X-ray	2IK8	-	2.7	-	-	-	-	-	-	-	Regulator of G-protein signaling 16	-	-	-	-	-	Soundararajan M, Willard FS, Kimple AJ, Turnbull AP, Ball LJ, Schoch GA, Gileadi C, Fedorov OY, Dowler EF, Higman VA, Hutsell SQ, Sundstrom M, Doyle DA, Siderovski DP	18434541	2006-11-21	56200
Gi/o	αi3	Human	-	91	-	-	-	-	X-ray	2IHB	-	2.7	-	-	-	-	-	-	-	Regulator of G-protein signalling 10	-	-	-	-	-	Soundararajan M, Willard FS, Kimple AJ, Turnbull AP, Ball LJ, Schoch GA, Gileadi C, Fedorov OY, Dowler EF, Higman VA, Hutsell SQ, Sundstrom M, Doyle DA, Siderovski DP	18434541	2006-11-21	56202
Gi/o	αi1	Human	-	88	-	-	-	-	X-ray	2G83	-	2.8	-	-	-	-	-	-	-	KB-1753 phage display peptide	-	-	-	-	-	Johnston CA, Lobanova ES, Shavkunov AS, Low J, Ramer JK, Blaesius R, Fredericks Z, Willard FS, Kuhlman B, Arshavsky VY, Siderovski DP	16981699	2006-10-10	56200
Gs	αs2	Bovine	-	100	-	-	-	-	X-ray	2GVD	-	2.9	-	-	-	-	-	-	-	Adenylate cyclase type 5 Adenylate cyclase type 2	-	-	-	-	-	Mou TC, Gille A, Suryanarayana S, Richter M, Seifert R, Sprang SR	16766715	2006-07-04	56215
Gs	αs2	Bovine	-	100	-	-	-	-	X-ray	2GVZ	-	3.3	-	-	-	-	-	-	-	Adenylate cyclase type 5 Adenylate cyclase type 2	-	-	-	-	-	Mou TC, Gille A, Suryanarayana S, Richter M, Seifert R, Sprang SR	16766715	2006-07-04	56215
Gi/o	αi1	Human	-	91	-	-	-	-	X-ray	2GTP	-	2.6	-	-	-	-	-	-	-	Regulator of G-protein signaling 1	-	-	-	-	-	Soundararajan M, Willard FS, Kimple AJ, Turnbull AP, Ball LJ, Schoch GA, Gileadi C, Fedorov OY, Dowler EF, Higman VA, Hutsell SQ, Sundstrom M, Doyle DA, Siderovski DP	18434541	2006-05-23	56200
Gi/o	αi1	Rat	-	100	β1	Bovine	γ2	Bovine	X-ray	2BCJ	-	3.1	-	-	-	-	-	-	-	G-protein-coupled receptor kinase 2	-	-	-	-	-	Tesmer VM, Kawano T, Shankaranarayanan A, Kozasa T, Tesmer JJ	16339447	2005-12-20	56260
G12/13	α12	Mouse	-	95	-	-	-	-	X-ray	1ZCA	-	2.9	-	-	-	-	-	-	-	-	-	-	-	-	-	Kreutz B, Yau DM, Nance MR, Tanabe S, Tesmer JJ, Kozasa T	16388592	2005-11-15	56486
G12/13	α13	Mouse	-	96	-	-	-	-	X-ray	1ZCB	-	2.0	-	-	-	-	-	-	-	-	-	-	-	-	-	Kreutz B, Yau DM, Nance MR, Tanabe S, Tesmer JJ, Kozasa T	16388592	2005-11-15	56505
Gi/o	αi1	Human	-	93	-	-	-	-	X-ray	1Y3A	-	2.5	-	-	-	-	-	-	-	KB752 peptide	-	-	-	-	-	Johnston CA, Willard FS, Jezyk MR, Fredericks Z, Bodor ET, Jones MB, Blaesius R, Watts VJ, Harden TK, Sondek J, Ramer JK, Siderovski DP	16004878	2005-07-12	56200
Gi/o	αi1	Rat	-	96	-	-	-	-	X-ray	1SHZ	-	2.9	-	-	-	-	-	-	-	Guanine Nucleotide-Binding Protein Galpha(13):Galpha(i1) Chimera Rho guanine nucleotide exchange factor 1	-	-	-	-	-	Chen Z, Singer WD, Sternweis PC, Sprang SR	15665872	2005-01-18	56260
Gs	αs2	Bovine	-	100	-	-	-	-	X-ray	1TL7	-	2.8	-	-	-	-	-	-	-	Adenylate cyclase type V Adenylate cyclase type II	-	-	-	-	-	Mou TC, Gille A, Fancy DA, Seifert R, Sprang SR	15591060	2004-12-14	56215
Gs	αs2	Bovine	-	100	-	-	-	-	X-ray	1U0H	-	2.9	-	-	-	-	-	-	-	Adenylate cyclase type V Adenylate cyclase type II	-	-	-	-	-	Mou TC, Gille A, Fancy DA, Seifert R, Sprang SR	15591060	2004-12-14	56215
Gi/o	αi1	Rat	-	100	-	-	-	-	X-ray	1SVK	-	2.0	-	-	-	-	-	-	-	-	-	-	-	-	-	Thomas CJ, Du X, Li P, Wang Y, Ross EM, Sprang SR	15128951	2004-06-01	56260
Gi/o	αi1	Rat	-	100	-	-	-	-	X-ray	1SVS	-	1.5	-	-	-	-	-	-	-	-	-	-	-	-	-	Thomas CJ, Du X, Li P, Wang Y, Ross EM, Sprang SR	15128951	2004-06-01	56260
Gi/o	αi1	Human	-	92	-	-	-	-	X-ray	1KJY	-	2.7	-	-	-	-	-	-	-	Regulator of G-protein signaling 14	-	-	-	-	-	Kimple RJ, Kimple ME, Betts L, Sondek J, Siderovski DP	11976690	2002-05-08	56200
Gi/o	αi1	Rat	-	92	-	-	-	-	X-ray	1FQJ	-	2.0	-	-	-	-	-	-	-	Regulator of G-protein signaling 9	-	-	-	-	-	Slep KC, Kercher MA, He W, Cowan CW, Wensel TG, Sigler PB	11234020	2001-02-28	56260
Gi/o	αi1	Rat	-	92	-	-	-	-	X-ray	1FQK	-	2.3	-	-	-	-	-	-	-	Regulator of G-protein signaling 9	-	-	-	-	-	Slep KC, Kercher MA, He W, Cowan CW, Wensel TG, Sigler PB	11234020	2001-02-28	56260
Gs	αs2	Bovine	-	100	-	-	-	-	X-ray	1CS4	-	2.5	-	-	-	-	-	-	-	TYPE V ADENYLATE CYCLASE TYPE II ADENYLATE CYCLASE	-	-	-	-	-	Tesmer JJ, Dessauer CW, Sunahara RK, Murray LD, Johnson RA, Gilman AG, Sprang SR	11087399	2001-01-10	56215
Gs	αs2	Bovine	-	96	-	-	-	-	X-ray	1CUL	-	2.4	-	-	-	-	-	-	-	TYPE V ADENYLYL CYCLASE TYPE II ADENYLYL CYCLASE	-	-	-	-	-	Tesmer JJ, Dessauer CW, Sunahara RK, Murray LD, Johnson RA, Gilman AG, Sprang SR	11087399	2001-01-10	56215
Gs	αs2	Bovine	-	100	-	-	-	-	X-ray	1CJK	-	3.0	-	-	-	-	-	-	-	Adenylate cyclase type V ADENYLATE CYCLASE TYPE II	-	-	-	-	-	Tesmer JJ, Sunahara RK, Johnson RA, Gosselin G, Gilman AG, Sprang SR	10427002	1999-08-31	56215
Gs	αs2	Bovine	-	100	-	-	-	-	X-ray	1CJT	-	2.8	-	-	-	-	-	-	-	Adenylate cyclase type V ADENYLATE CYCLASE TYPE II	-	-	-	-	-	Tesmer JJ, Sunahara RK, Johnson RA, Gosselin G, Gilman AG, Sprang SR	10427002	1999-08-31	56215
Gs	αs2	Bovine	-	100	-	-	-	-	X-ray	1CJU	-	2.8	-	-	-	-	-	-	-	Adenylate cyclase type V ADENYLATE CYCLASE TYPE II	-	-	-	-	-	Tesmer JJ, Sunahara RK, Johnson RA, Gosselin G, Gilman AG, Sprang SR	10427002	1999-08-31	56215
Gs	αs2	Bovine	-	100	-	-	-	-	X-ray	1CJV	-	3.0	-	-	-	-	-	-	-	Adenylate cyclase type V ADENYLATE CYCLASE TYPE II	-	-	-	-	-	Tesmer JJ, Sunahara RK, Johnson RA, Gosselin G, Gilman AG, Sprang SR	10427002	1999-08-31	56215
Gi/o	αi1	Rat	-	100	-	-	-	-	X-ray	1CIP	-	1.5	-	-	-	-	-	-	-	-	-	-	-	-	-	Coleman DE, Sprang SR	10358003	1999-04-09	56260
Gi/o	αi1	Rat	-	100	-	-	-	-	X-ray	1BOF	-	2.2	-	-	-	-	-	-	-	-	-	-	-	-	-	Coleman DE, Sprang SR	9772163	1999-01-06	56260
Gi/o	αi1	Rat	-	89	-	-	-	-	X-ray	1BH2	-	2.1	-	-	-	-	-	-	-	-	-	-	-	-	-	Posner BA, Mixon MB, Wall MA, Sprang SR, Gilman AG	9705312	1998-11-04	56260
Gs	αs2	Bovine	-	100	-	-	-	-	X-ray	1AZS	-	2.3	-	-	-	-	-	-	-	VC1 IIC2	-	-	-	-	-	Tesmer JJ, Sunahara RK, Gilman AG, Sprang SR	9417641	1998-02-25	56215
Gs	αs2	Bovine	-	100	-	-	-	-	X-ray	1AZT	-	2.3	-	-	-	-	-	-	-	-	-	-	-	-	-	Sunahara RK, Tesmer JJ, Gilman AG, Sprang SR	9395396	1998-02-25	56215
Gi/o	αi1	Rat	-	100	-	-	-	-	X-ray	1AS0	-	2.0	-	-	-	-	-	-	-	-	-	-	-	-	-	Raw AS, Coleman DE, Gilman AG, Sprang SR	9398294	1997-11-12	56260
Gi/o	αi1	Rat	-	100	-	-	-	-	X-ray	1AS2	-	2.8	-	-	-	-	-	-	-	-	-	-	-	-	-	Raw AS, Coleman DE, Gilman AG, Sprang SR	9398294	1997-11-12	56260
Gi/o	αi1	Rat	-	100	-	-	-	-	X-ray	1AS3	-	2.4	-	-	-	-	-	-	-	-	-	-	-	-	-	Raw AS, Coleman DE, Gilman AG, Sprang SR	9398294	1997-11-12	56260
Gi/o	αi1	Rat	-	100	-	-	-	-	X-ray	1AGR	-	2.8	-	-	-	-	-	-	-	RGS4	-	-	-	-	-	Tesmer JJ, Berman DM, Gilman AG, Sprang SR	9108480	1997-06-16	56260
Gi/o	αt1	Bovine	-	100	β1	Bovine	γT1	Bovine	X-ray	1GOT	-	2.0	-	-	-	-	-	-	-	-	-	-	-	-	-	Lambright DG, Sondek J, Bohm A, Skiba NP, Hamm HE, Sigler PB	8552184	1997-03-12	56310
Gi/o	αi1	Rat	-	100	β1	Bovine	γ2	Bovine	X-ray	1GG2	-	2.4	-	-	-	-	-	-	-	-	-	-	-	-	-	Wall MA, Coleman DE, Lee E, Iniguez-Lluhi JA, Posner BA, Gilman AG, Sprang SR	8521505	1997-02-12	56260
Gi/o	αi1	Rat	-	100	-	-	-	-	X-ray	1GIT	-	2.6	-	-	-	-	-	-	-	-	-	-	-	-	-	Berghuis AM, Lee E, Raw AS, Gilman AG, Sprang SR	8939752	1997-02-12	56260
Gi/o	αi1	Rat	-	100	β1	Bovine	γ2	Bovine	X-ray	1GP2	-	2.3	-	-	-	-	-	-	-	-	-	-	-	-	-	Wall MA, Coleman DE, Lee E, Iniguez-Lluhi JA, Posner BA, Gilman AG, Sprang SR	8521505	1997-02-12	56260
Gi/o	αi1	Rat	-	100	-	-	-	-	X-ray	1GDD	-	2.2	-	-	-	-	-	-	-	-	-	-	-	-	-	Mixon MB, Lee E, Coleman DE, Berghuis AM, Gilman AG, Sprang SR	7481799	1995-11-27	56260
Gi/o	αt1	Bovine	-	93	-	-	-	-	X-ray	1TAD	-	1.7	-	-	-	-	-	-	-	-	-	-	-	-	-	Sondek J, Lambright DG, Noel JP, Hamm HE, Sigler PB	7969474	1995-05-08	56310
Gi/o	αi1	Rat	-	100	-	-	-	-	X-ray	1GFI	-	2.2	-	-	-	-	-	-	-	-	-	-	-	-	-	Coleman DE, Berghuis AM, Lee E, Linder ME, Gilman AG, Sprang SR	8073283	1995-03-31	56260
Gi/o	αi1	Rat	-	100	-	-	-	-	X-ray	1GIL	-	2.3	-	-	-	-	-	-	-	-	-	-	-	-	-	Coleman DE, Berghuis AM, Lee E, Linder ME, Gilman AG, Sprang SR	8073283	1995-02-14	56260
Gi/o	αt1	Bovine	-	93	-	-	-	-	X-ray	1TAG	-	1.8	-	-	-	-	-	-	-	-	-	-	-	-	-	Lambright DG, Noel JP, Hamm HE, Sigler PB	8208289	1995-02-07	56310
Gi/o	αi1	Rat	-	100	-	-	-	-	X-ray	1GIA	-	2.0	-	-	-	-	-	-	-	-	-	-	-	-	-	Coleman DE, Berghuis AM, Lee E, Linder ME, Gilman AG, Sprang SR	8073283	1994-09-30	56260
Gi/o	αt1	Bovine	-	93	-	-	-	-	X-ray	1TND	-	2.2	-	-	-	-	-	-	-	-	-	-	-	-	-	Noel JP, Hamm HE, Sigler PB	8259210	1994-07-31	56310

G12/13	α13
G12/13	α13
Gi/o	αi1
Gi/o	αi1
Gq/11	αq
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gq/11	αq
Gq/11	αq
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gs	αs
Gi/o	αi1
Gi/o	αi2
Gi/o	αgust
Gs	αs
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
G12/13	α13
G12/13	α13
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gs	αs
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gq/11	αq
Gi/o	αi3
Gi/o	αi1
Gi/o	αi1
Gq/11	αq
Gq/11	αq
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gi/o	αi1
Gi/o	αi1
Gi/o	αo
Gi/o	αo
Gq/11	αq
Gq/11	αq
Gs	αs
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gq/11	αq
Gq/11	αq
Gs	αs
Gs	αs
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gs	αs
Gs	αs
Gi/o	αi1
Gq/11	αq
Gs	αs
Gi/o	αo
Gi/o	αi1
Gi/o	αo
Gq/11	αq
Gs	αs
Gs	αs
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gq/11	αq
Gq/11	αq
Gs	αs
Gs	αs
Gs	αs
Gi/o	αi1
Gi/o	αo
Gi/o	αi1
Gi/o	αo
Gs	αs
Gs	αs
Gs	αs
Gs	αs
G12/13	α13
Gi/o	αi2
Gi/o	αi2
Gi/o	αi2
Gi/o	αi1
Gi/o	αgust
Gi/o	αi1
Gi/o	αi1
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gi/o	αi1
Gi/o	αgust
Gi/o	αi1
Gi/o	αgust
Gi/o	αi1
Gi/o	αgust
Gi/o	αi1
Gi/o	αi1
Gi/o	αgust
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gq/11	αq
Gq/11	αq
Gq/11	αq
Gi/o	αi1
Gi/o	αi1
Gq/11	αq
Gq/11	αq
Gs	αs
Gs	αs
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gs	αs
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gi/o	αi3
Gi/o	αi3
Gi/o	αi1
Gq/11	αq
Gq/11	αq
Gi/o	αi1
Gq/11	αq
Gs	αs
Gs	αs
Gs	αs
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gi/o	αi3
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gs	αs
Gs	αs
Gi/o	αi1
Gi/o	αi1
Gi/o	αi3
Gq/11	αq
Gq/11	αq
Gs	αs
Gi/o	αi1
Gq/11	αq
Gq/11	αq
Gq/11	αq
Gq/11	αq
Gq/11	αq
Gi/o	αgust
Gi/o	αt1
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gs	αs
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gi/o	αo
Gi/o	αo
Gi/o	αo
Gi/o	αo
Gi/o	αo
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs2
Gi/o	αi1
Gi/o	αi1
Gq/11	αq
Gq/11	αq
Gq/11	αq
Gq/11	αq
Gq/11	αq
Gq/11	αq
Gs	αs
Gi/o	αo
Gi/o	αo
Gs	αs
Gs	αs
Gi/o	αi1
Gi/o	αi1
Gi/o	αi3
Gi/o	αi1
Gi/o	αi1
Gi/o	αi3
Gi/o	αi1
Gq/11	αq
Gq/11	αq
Gq/11	αq
Gs	αs
Gs	αs
G12/13	α13
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gq/11	αq
Gq/11	αq
Gq/11	αq
Gq/11	αq
Gq/11	αq
Gs	αs
Gs	αs
Gs	αs2
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gq/11	αq
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gs	αs
Gs	αs
Gi/o	αi1
Gq/11	αq
Gq/11	αq
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gs	αs
Gs	αl
Gs	αs2
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gq/11	αq
Gq/11	αq
Gq/11	αq
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gq/11	αq
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gi/o	αi1
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gi/o	αi1
Gs	αs
Gi/o	αi1
Gi/o	αi1
Gs	αs
Gi/o	αi1
Gq/11	αq
Gq/11	αq
Gi/o	αo
Gi/o	αo
Gi/o	αo
Gi/o	αo
Gi/o	αo
Gi/o	αo
Gi/o	αo
Gi/o	αo
Gi/o	αo
Gq/11	αq
Gs	αs
Gs	αs
Gs	αs
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gs	αs
Gs	αs
Gi/o	αi1
Gi/o	αi1
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gi/o	αi1
Gi/o	αi1
Gs	αs
Gs	αs
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gs	αs
Gs	αs
Gs	αs
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gq/11	αq
Gq/11	αq
Gq/11	αq
Gq/11	αq
Gq/11	αq
Gq/11	αq
Gq/11	αq
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gi/o	αi1
G12/13	α12
G12/13	α13
Gq/11	αq
Gq/11	αq
Gq/11	αq
Gq/11	αq
Gs	αs
Gq/11	αq
Gq/11	αq
Gs	αs
Gs	αs
Gs	αs
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gi/o	αi3
Gi/o	αi1
Gi/o	αi1
Gq/11	αq
Gq/11	αq
Gq/11	αq
Gs	αs
Gs	αs
Gs	αs
Gs	αs
Gi/o	αi2
Gi/o	αi1
Gi/o	αi1
Gq/11	α11
Gs	αs
Gs	αs
Gq/11	αq
Gq/11	αq
Gs	αs
Gs	αs
Gs	αolf
Gs	αs
Gs	αs
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gi/o	αi3
Gq/11	αq
Gq/11	αq
Gq/11	αq
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gi/o	αi1
Gq/11	αq
Gi/o	αgust
Gi/o	αo
Gi/o	αi1
Gi/o	αo
Gi/o	αz

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	G protein family	Subtype	PDB	UniProt	IUPHAR	Rec. family	Class	Species	PDB Date

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