GproteinDb

Excel (underlying datasets)

See the Datasets and Biosensors pages for more information about the underlying data.

Receptor						Source					Ligand		No. supporting datasets				Selectivity		Family rank orders				% of 1' G protein family				Quantitative values						% of 1' G protein subtype																Quantitative values
Uniprot	GtoPdb (IUPHAR)	GPCRdb	Rec. family	Cl	Other protein	Lab	Biosensor	Down- stream steps	#Gprots tested	Ref	Name	Phys. / Surr.	Gs	Gi/o	Gq/11	G12/13	Primary family	#Fam	Gs	Gi/o	Gq/11	G12/13	Gs	Gi/o	Gq/11	G12/13	Parameter	Gs	Gi/o	Gq/11	G12/13	Primary subtype	GsL	GsS	Golf	Gi1	Gi2	Gi3	Ggust	Gz	GoA	GoB	Gq	G11	G14	G15	G12	G13	Parameter	GsL	GsS	Golf	Gi1	Gi2	Gi3	Ggust	Gz	GoA	GoB	Gq	G11	G14	G15	G12	G13

5HT1A	5-HT_1A		5-Hydroxytryptamine	A	-	Bouvier	GEMTA	3	12		5-hydroxytryptamine	Phys	-	3	2	-	Gi/o	2	nc	1'	2'	nc	0	100	81	0	log(Emax/EC50)	0.0	8.3	6.7	0.0	GoB	0	-	-	92	85	-	-	96	97	100	0	0	65	81	0	0	log(Emax/EC50)	0.0	-	-	7.6	7.0	-	-	7.9	8.0	8.3	0.0	0.0	5.4	6.7	0.0	0.0
5HT1A	5-HT_1A		5-Hydroxytryptamine	A	-	Martemyanov	FreeGβγ-Nluc	2	5		5-hydroxytryptamine	Phys	-	3	2	-	Gi/o	2	nc	1'	2'	nc	0	100	1	0	Activation rate (s^-1)	0.0	7.4	0.1	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	1	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	7.4	-	0.0	-	-	0.1	-	0.0
5HT1A	5-HT_1A		5-Hydroxytryptamine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	3	2	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT1A	5-HT_1A		5-Hydroxytryptamine	A	-	GproteinDb	merged data	-	-	-	-	-	-	3	2	-	Gi/o	2	nc	1'	2'	nc	0	100	41	0	-	-	-	-	-	GoB	0	-	-	92	85	-	-	96	98	100	0	0	65	41	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT1B	5-HT_1B		5-Hydroxytryptamine	A	-	Bouvier	GEMTA	3	12		5-hydroxytryptamine	Phys	-	3	1	-	Gi/o	2	nc	1'	2'	nc	0	100	71	0	log(Emax/EC50)	0.0	8.7	6.2	0.0	GoB	0	-	-	99	98	-	-	93	98	100	0	0	0	71	0	0	log(Emax/EC50)	0.0	-	-	8.6	8.6	-	-	8.1	8.5	8.7	0.0	0.0	0.0	6.2	0.0	0.0
5HT1B	5-HT_1B		5-Hydroxytryptamine	A	-	Martemyanov	FreeGβγ-Nluc	2	5		5-hydroxytryptamine	Phys	-	3	1	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Activation rate (s^-1)	0.0	0.4	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.4	-	0.0	-	-	0.0	-	0.0
5HT1B	5-HT_1B		5-Hydroxytryptamine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	3	1	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT1B	5-HT_1B		5-Hydroxytryptamine	A	-	GproteinDb	merged data	-	-	-	-	-	-	3	1	-	Gi/o	2	nc	1'	2'	nc	0	100	36	0	-	-	-	-	-	GoB	0	-	-	99	98	-	-	93	99	100	0	0	0	36	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT1D	5-HT_1D		5-Hydroxytryptamine	A	-	Bouvier	GEMTA	3	12		5-hydroxytryptamine	Phys	-	3	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	log(Emax/EC50)	0.0	8.6	0.0	0.0	Gi1	0	-	-	100	100	-	-	43	94	94	0	0	0	0	0	0	log(Emax/EC50)	0.0	-	-	8.6	8.6	-	-	3.7	8.1	8.1	0.0	0.0	0.0	0.0	0.0	0.0
5HT1D	5-HT_1D		5-Hydroxytryptamine	A	-	Martemyanov	FreeGβγ-Nluc	2	5		5-hydroxytryptamine	Phys	-	3	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Activation rate (s^-1)	0.0	0.2	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.2	-	0.0	-	-	0.0	-	0.0
5HT1D	5-HT_1D		5-Hydroxytryptamine	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	3	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT1D	5-HT_1D		5-Hydroxytryptamine	A	-	GproteinDb	merged data	-	-	-	-	-	-	3	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	-	-	-	-	-	Gi1	0	-	-	100	100	-	-	43	97	94	0	0	0	0	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT1E	5-HT_1E		5-Hydroxytryptamine	A	-	Martemyanov	FreeGβγ-Nluc	2	5		5-hydroxytryptamine	Phys	-	2	-	-	Gi/o	1	nc	1'	2'	nc	0	100	2	0	Activation rate (s^-1)	0.0	0.9	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	2	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.9	-	0.0	-	-	0.0	-	0.0
5HT1E	5-HT_1E		5-Hydroxytryptamine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	2	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT1E	5-HT_1E		5-Hydroxytryptamine	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	-	-	Gi/o	2	nc	1'	2'	nc	0	100	2	0	-	-	-	-	-	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	2	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT1F	5-HT_1F		5-Hydroxytryptamine	A	-	Martemyanov	FreeGβγ-Nluc	2	5		5-hydroxytryptamine	Phys	-	2	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Activation rate (s^-1)	0.0	0.4	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.4	-	0.0	-	-	0.0	-	0.0
5HT1F	5-HT_1F		5-Hydroxytryptamine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	2	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT1F	5-HT_1F		5-Hydroxytryptamine	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	-	-	-	-	-	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT2A	5-HT_2A		5-Hydroxytryptamine	A	-	Bouvier	GEMTA	3	12		5-hydroxytryptamine	Phys	-	3	5	-	Gq/11	2	nc	2'	1'	nc	0	77	100	0	log(Emax/EC50)	0.0	6.7	8.6	0.0	G14	0	-	-	68	63	-	-	77	62	66	98	99	100	93	0	0	log(Emax/EC50)	0.0	-	-	5.9	5.5	-	-	6.7	5.4	5.7	8.4	8.5	8.6	8.0	0.0	0.0
5HT2A	5-HT_2A		5-Hydroxytryptamine	A	-	Lambert	RGB-GDP	0	6	-	None (constitutive activity)	-	-	3	5	-	-	0	nc	nc	nc	nc	0	0	0	0	Econstitutive	0.00	0.00	0.00	0.00	-	0	-	-	0	-	-	-	-	-	-	0	-	-	-	0	-	Econstitutive	0.00	-	-	0.00	-	-	-	-	-	-	0.00	-	-	-	0.00	-
5HT2A	5-HT_2A		5-Hydroxytryptamine	A	-	Lambert	RGB-GDP	0	6	-	5-hydroxytryptamine	Phys	-	3	5	-	Gq/11	1	nc	nc	1'	nc	0	0	100	0	Efficacy	0.00	0.00	0.01	0.00	Gq	0	-	-	0	-	-	-	-	-	-	100	-	-	-	0	-	Efficacy	0.00	-	-	0.00	-	-	-	-	-	-	0.01	-	-	-	0.00	-
5HT2A	5-HT_2A		5-Hydroxytryptamine	A	-	Martemyanov	FreeGβγ-Nluc	2	5		5-hydroxytryptamine	Phys	-	3	5	-	Gq/11	2	nc	2'	1'	nc	0	12	100	0	Activation rate (s^-1)	0.0	0.1	0.5	0.0	Gq	0	-	-	-	-	-	-	-	12	-	100	-	-	17	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.1	-	0.5	-	-	0.1	-	0.0
5HT2A	5-HT_2A		5-Hydroxytryptamine	A	-	Inoue	TGF𝛼	5	1		5-hydroxytryptamine	Phys	-	3	5	-	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	7.2	-	-	-	-	-
5HT2A	5-HT_2A		5-Hydroxytryptamine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	3	5	-	Gq/11	2	-	2'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT2A	5-HT_2A		5-Hydroxytryptamine	A	-	GproteinDb	merged data	-	-	-	-	-	-	3	5	-	Gq/11	2	nc	2'	1'	nc	0	22	75	0	-	-	-	-	-	G14	0	-	-	23	63	-	-	77	37	66	74	99	100	55	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT2B	5-HT_2B		5-Hydroxytryptamine	A	-	Bouvier	GEMTA	3	12		5-hydroxytryptamine	Phys	-	1	4	-	Gq/11	2	nc	2'	1'	nc	0	99	100	0	log(Emax/EC50)	0.0	7.7	7.8	0.0	Gq	0	-	-	0	0	-	-	99	0	85	100	100	97	90	0	0	log(Emax/EC50)	0.0	-	-	0.0	0.0	-	-	7.7	0.0	6.6	7.8	7.8	7.5	7.0	0.0	0.0
5HT2B	5-HT_2B		5-Hydroxytryptamine	A	-	Martemyanov	FreeGβγ-Nluc	2	5		5-hydroxytryptamine	Phys	-	1	4	-	Gq/11	1	nc	nc	1'	nc	0	0	100	0	Activation rate (s^-1)	0.0	0.0	0.1	0.0	Gq	0	-	-	-	-	-	-	-	0	-	100	-	-	0	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.0	-	0.1	-	-	0.0	-	0.0
5HT2B	5-HT_2B		5-Hydroxytryptamine	A	-	Inoue	TGF𝛼	5	1		5-hydroxytryptamine	Phys	-	1	4	-	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	7.6	-	-	-	-	-
5HT2B	5-HT_2B		5-Hydroxytryptamine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	1	4	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT2B	5-HT_2B		5-Hydroxytryptamine	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	4	-	Gq/11	2	nc	2'	1'	nc	0	50	100	0	-	-	-	-	-	Gq	0	-	-	0	0	-	-	99	0	85	100	100	97	45	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT2C	5-HT_2C		5-Hydroxytryptamine	A	-	Bouvier	GEMTA	3	12		5-hydroxytryptamine	Phys	-	3	4	1	Gi/o	3	nc	1'	2'	3'	0	100	97	84	log(Emax/EC50)	0.0	8.7	8.4	7.3	Gz	0	-	-	79	77	-	-	100	78	84	0	0	0	97	84	84	log(Emax/EC50)	0.0	-	-	6.9	6.7	-	-	8.7	6.8	7.3	0.0	0.0	0.0	8.4	7.3	7.3
5HT2C	5-HT_2C		5-Hydroxytryptamine	A	-	Martemyanov	FreeGβγ-Nluc	2	5		5-hydroxytryptamine	Phys	-	3	4	1	Gq/11	2	nc	2'	1'	3'	0	1	100	0	Activation rate (s^-1)	0.0	0.1	10.3	0.0	Gq	0	-	-	-	-	-	-	-	1	-	100	-	-	1	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.1	-	10.3	-	-	0.1	-	0.0
5HT2C	5-HT_2C		5-Hydroxytryptamine	A	-	Inoue	TGF𝛼	5	1		5-hydroxytryptamine	Phys	-	3	4	1	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	7.4	-	-	-	-	-
5HT2C	5-HT_2C		5-Hydroxytryptamine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	3	4	1	Gq/11	2	-	2'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT2C	5-HT_2C		5-Hydroxytryptamine	A	-	GproteinDb	merged data	-	-	-	-	-	-	3	4	1	Gq/11	3	nc	2'	1'	3'	0	50	98	42	-	-	-	-	-	Gz	0	-	-	79	77	-	-	100	40	84	50	0	0	49	84	42	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT4R	5-HT₄		5-Hydroxytryptamine	A	-	Martemyanov	FreeGβγ-Nluc	2	5		5-hydroxytryptamine	Phys	2	1	1	2	Gs	4	1'	3'	2'	4'	100	4	9	2	Activation rate (s^-1)	4.2	0.2	0.4	0.1	GsL	100	-	-	-	-	-	-	-	4	-	0	-	-	9	-	2	Activation rate (s^-1)	4.2	-	-	-	-	-	-	-	0.2	-	0.0	-	-	0.4	-	0.1
5HT4R	5-HT₄		5-Hydroxytryptamine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	2	1	1	2	Gs	2	1'	-	-	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT4R	5-HT₄		5-Hydroxytryptamine	A	-	GproteinDb	merged data	-	-	-	-	-	2	1	1	2	Gs	4	1'	3'	2'	4'	100	4	9	2	-	-	-	-	-	GsL	100	-	-	-	-	-	-	-	4	-	0	-	-	9	-	2	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT5A	5-HT_5A		5-Hydroxytryptamine	A	-	Martemyanov	FreeGβγ-Nluc	2	5		5-hydroxytryptamine	Phys	-	2	1	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Activation rate (s^-1)	0.0	0.1	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.1	-	0.0	-	-	0.0	-	0.0
5HT5A	5-HT_5A		5-Hydroxytryptamine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	2	1	-	Gi/o	2	-	1'	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT5A	5-HT_5A		5-Hydroxytryptamine	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	1	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	-	-	-	-	-	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT6R	5-HT₆		5-Hydroxytryptamine	A	-	Martemyanov	FreeGβγ-Nluc	2	5		5-hydroxytryptamine	Phys	2	-	2	1	Gs	3	1'	nc	2'	3'	100	0	26	11	Activation rate (s^-1)	0.9	0.0	0.2	0.1	GsL	100	-	-	-	-	-	-	-	0	-	0	-	-	26	-	11	Activation rate (s^-1)	0.9	-	-	-	-	-	-	-	0.0	-	0.0	-	-	0.2	-	0.1
5HT6R	5-HT₆		5-Hydroxytryptamine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	2	-	2	1	Gs	2	1'	-	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT6R	5-HT₆		5-Hydroxytryptamine	A	-	GproteinDb	merged data	-	-	-	-	-	2	-	2	1	Gs	3	1'	nc	2'	3'	100	0	26	11	-	-	-	-	-	GsL	100	-	-	-	-	-	-	-	0	-	0	-	-	26	-	11	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT7R	5-HT₇		5-Hydroxytryptamine	A	-	Martemyanov	FreeGβγ-Nluc	2	5		5-hydroxytryptamine	Phys	3	1	1	-	Gs	2	1'	2'	nc	nc	100	22	0	0	Activation rate (s^-1)	0.9	0.2	0.0	0.0	GsL	100	-	-	-	-	-	-	-	22	-	0	-	-	0	-	0	Activation rate (s^-1)	0.9	-	-	-	-	-	-	-	0.2	-	0.0	-	-	0.0	-	0.0
5HT7R	5-HT₇		5-Hydroxytryptamine	A	-	Roth	TRUPATH	1	15		5-hydroxytryptamine	Phys	3	1	1	-	Gs	1	1'	nc	nc	nc	100	0	0	0	log(Emax/EC50)	100.0	0.0	0.0	0.0	GsS	99	100	99	0	0	0	0	0	0	0	0	0	-	0	0	0	log(Emax/EC50)	7.8	7.9	7.8	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	-	0.0	0.0	0.0
5HT7R	5-HT₇		5-Hydroxytryptamine	A	-	Inoue	TGF𝛼	5	1		5-hydroxytryptamine	Phys	3	1	1	-	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	7.8	-	-	-	-	-
5HT7R	5-HT₇		5-Hydroxytryptamine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	3	1	1	-	Gs	1	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5HT7R	5-HT₇		5-Hydroxytryptamine	A	-	GproteinDb	merged data	-	-	-	-	-	3	1	1	-	Gs	2	1'	2'	nc	nc	100	11	0	0	-	-	-	-	-	GsL	100	100	99	0	0	0	0	0	11	0	0	0	-	0	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ACM1	M₁		Acetylcholine (muscarinic)	A	-	Bouvier	GEMTA	3	12		acetylcholine	Phys	1	2	4	-	Gq/11	3	2'	3'	1'	nc	75	68	100	0	log(Emax/EC50)	5.8	5.3	7.8	0.0	G11	75	-	-	64	59	-	-	68	57	61	97	100	98	99	0	0	log(Emax/EC50)	5.8	-	-	4.9	4.6	-	-	5.3	4.4	4.8	7.5	7.8	7.6	7.6	0.0	0.0
ACM1	M₁		Acetylcholine (muscarinic)	A	-	Martemyanov	FreeGβγ-Nluc	2	5		acetylcholine	Phys	1	2	4	-	Gq/11	2	nc	2'	1'	nc	0	5	100	0	Activation rate (s^-1)	0.0	0.1	2.4	0.0	Gq	0	-	-	-	-	-	-	-	5	-	100	-	-	55	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.1	-	2.4	-	-	1.3	-	0.0
ACM1	M₁		Acetylcholine (muscarinic)	A	-	Inoue	TGF𝛼	5	1		acetylcholine	Phys	1	2	4	-	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	7.5	-	-	-	-	-
ACM1	M₁		Acetylcholine (muscarinic)	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	1	2	4	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ACM1	M₁		Acetylcholine (muscarinic)	A	-	GproteinDb	merged data	-	-	-	-	-	1	2	4	-	Gq/11	3	2'	3'	1'	nc	38	36	100	0	-	-	-	-	-	G11	38	-	-	64	59	-	-	68	31	61	98	100	98	77	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ACM2	M₂		Acetylcholine (muscarinic)	A	-	Bouvier	GEMTA	3	12		acetylcholine	Phys	2	3	2	-	Gi/o	3	3'	1'	2'	nc	65	100	86	0	log(Emax/EC50)	5.6	8.6	7.4	0.0	GoB	65	-	-	92	88	-	-	92	94	100	0	0	52	86	0	0	log(Emax/EC50)	5.6	-	-	7.9	7.6	-	-	8.0	8.1	8.6	0.0	0.0	4.5	7.4	0.0	0.0
ACM2	M₂		Acetylcholine (muscarinic)	A	-	Martemyanov	FreeGβγ-Nluc	2	5		acetylcholine	Phys	2	3	2	-	Gi/o	1	nc	1'	2'	nc	0	100	2	0	Activation rate (s^-1)	0.0	1.3	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	2	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	1.3	-	0.0	-	-	0.0	-	0.0
ACM2	M₂		Acetylcholine (muscarinic)	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	2	3	2	-	Gi/o	3	2'	1'	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ACM2	M₂		Acetylcholine (muscarinic)	A	-	GproteinDb	merged data	-	-	-	-	-	2	3	2	-	Gi/o	3	3'	1'	2'	nc	32	100	44	0	-	-	-	-	-	GoB	32	-	-	92	88	-	-	92	97	100	0	0	52	44	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DRD2	D₂		Dopamine	A	-	Bouvier	GEMTA	3	12		dopamine	Phys	1	5	2	-	Gi/o	2	nc	1'	2'	nc	0	100	61	0	log(Emax/EC50)	0.0	8.6	5.3	0.0	GoB	0	-	-	93	87	-	-	86	93	100	0	0	0	61	0	0	log(Emax/EC50)	0.0	-	-	8.0	7.5	-	-	7.4	8.0	8.6	0.0	0.0	0.0	5.3	0.0	0.0
DRD2	D₂		Dopamine	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	1	5	2	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Econstitutive	0.00	0.03	0.00	0.00	Gi1	0	-	-	100	-	-	-	-	-	-	0	-	-	-	0	-	Econstitutive	0.00	-	-	0.03	-	-	-	-	-	-	0.00	-	-	-	0.00	-
DRD2	D₂		Dopamine	A	-	Lambert	RGB-GDP	0	6		dopamine	Phys	1	5	2	-	Gi/o	3	3'	1'	2'	nc	7	100	8	0	Efficacy	0.01	0.14	0.01	0.00	Gi1	7	-	-	100	-	-	-	-	-	-	8	-	-	-	0	-	Efficacy	0.01	-	-	0.14	-	-	-	-	-	-	0.01	-	-	-	0.00	-
DRD2	D₂		Dopamine	A	-	Martemyanov	FreeGβγ-Nluc	2	5		dopamine	Phys	1	5	2	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Activation rate (s^-1)	0.0	4.2	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	4.2	-	0.0	-	-	0.0	-	0.0
DRD2	D₂		Dopamine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	1	5	2	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DRD2	D₂		Dopamine	A	-	GproteinDb	merged data	-	-	-	-	-	1	5	2	-	Gi/o	3	3'	1'	2'	nc	2	100	17	0	-	-	-	-	-	GoB	2	-	-	98	87	-	-	86	96	100	2	0	0	30	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ACM3	M₃		Acetylcholine (muscarinic)	A	-	Bouvier	GEMTA	3	12		acetylcholine	Phys	1	3	6	-	Gq/11	2	nc	2'	1'	nc	0	72	100	0	log(Emax/EC50)	0.0	5.4	7.6	0.0	G15	0	-	-	72	65	-	-	67	67	69	94	97	97	100	0	0	log(Emax/EC50)	0.0	-	-	5.4	4.9	-	-	5.1	5.0	5.2	7.1	7.4	7.3	7.6	0.0	0.0
ACM3	M₃		Acetylcholine (muscarinic)	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	1	3	6	-	Gq/11	1	nc	nc	1'	nc	0	0	100	0	Econstitutive	0.00	0.00	0.02	0.00	Gq	0	-	-	0	-	-	-	-	-	-	100	-	-	-	0	-	Econstitutive	0.00	-	-	0.00	-	-	-	-	-	-	0.02	-	-	-	0.00	-
ACM3	M₃		Acetylcholine (muscarinic)	A	-	Lambert	RGB-GDP	0	6		acetylcholine	Phys	1	3	6	-	Gq/11	3	3'	2'	1'	nc	15	67	100	0	Efficacy	0.02	0.09	0.13	0.00	Gq	15	-	-	67	-	-	-	-	-	-	100	-	-	-	0	-	Efficacy	0.02	-	-	0.09	-	-	-	-	-	-	0.13	-	-	-	0.00	-
ACM3	M₃		Acetylcholine (muscarinic)	A	-	Martemyanov	FreeGβγ-Nluc	2	5		acetylcholine	Phys	1	3	6	-	Gq/11	2	nc	2'	1'	nc	0	13	100	0	Activation rate (s^-1)	0.0	0.6	5.0	0.0	Gq	0	-	-	-	-	-	-	-	13	-	100	-	-	49	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.6	-	5.0	-	-	2.5	-	0.0
ACM3	M₃		Acetylcholine (muscarinic)	A	-	Inoue	TGF𝛼	5	1		acetylcholine	Phys	1	3	6	-	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	8.1	-	-	-	-	-
ACM3	M₃		Acetylcholine (muscarinic)	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	1	3	6	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ACM3	M₃		Acetylcholine (muscarinic)	A	-	GproteinDb	merged data	-	-	-	-	-	1	3	6	-	Gq/11	3	3'	2'	1'	nc	4	38	100	0	-	-	-	-	-	Gq	4	-	-	46	65	-	-	67	40	69	98	97	97	74	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ACM4	M₄		Acetylcholine (muscarinic)	A	-	Bouvier	GEMTA	3	12		acetylcholine	Phys	1	5	3	1	Gi/o	2	nc	1'	2'	nc	0	100	78	0	log(Emax/EC50)	0.0	8.7	6.9	0.0	GoB	0	-	-	93	94	-	-	90	92	100	52	0	56	78	0	0	log(Emax/EC50)	0.0	-	-	8.1	8.2	-	-	7.9	8.0	8.7	4.6	0.0	4.9	6.9	0.0	0.0
ACM4	M₄		Acetylcholine (muscarinic)	A	-	Lambert	RGB-GDP	0	6		acetylcholine	Phys	1	5	3	1	Gi/o	4	2'	1'	4'	3'	16	100	9	11	Efficacy	0.06	0.39	0.04	0.04	Gi1	16	-	-	100	-	-	-	-	-	-	9	-	-	-	11	-	Efficacy	0.06	-	-	0.39	-	-	-	-	-	-	0.04	-	-	-	0.04	-
ACM4	M₄		Acetylcholine (muscarinic)	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	1	5	3	1	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Econstitutive	0.00	0.14	0.00	0.00	Gi1	0	-	-	100	-	-	-	-	-	-	0	-	-	-	0	-	Econstitutive	0.00	-	-	0.14	-	-	-	-	-	-	0.00	-	-	-	0.00	-
ACM4	M₄		Acetylcholine (muscarinic)	A	-	Martemyanov	FreeGβγ-Nluc	2	5		acetylcholine	Phys	1	5	3	1	Gi/o	2	nc	1'	2'	nc	0	100	3	0	Activation rate (s^-1)	0.0	5.8	0.2	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	3	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	5.8	-	0.0	-	-	0.2	-	0.0
ACM4	M₄		Acetylcholine (muscarinic)	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	1	5	3	1	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ACM4	M₄		Acetylcholine (muscarinic)	A	-	GproteinDb	merged data	-	-	-	-	-	1	5	3	1	Gi/o	4	3'	1'	2'	4'	4	100	22	3	-	-	-	-	-	GoB	4	-	-	98	94	-	-	90	96	100	15	0	56	40	4	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ACM5	M₅		Acetylcholine (muscarinic)	A	-	Martemyanov	FreeGβγ-Nluc	2	5		acetylcholine	Phys	-	1	3	-	Gq/11	2	nc	2'	1'	nc	0	6	100	0	Activation rate (s^-1)	0.0	0.2	2.8	0.0	Gq	0	-	-	-	-	-	-	-	6	-	100	-	-	53	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.2	-	2.8	-	-	1.5	-	0.0
ACM5	M₅		Acetylcholine (muscarinic)	A	-	Inoue	TGF𝛼	5	1		acetylcholine	Phys	-	1	3	-	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	8.1	-	-	-	-	-
ACM5	M₅		Acetylcholine (muscarinic)	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	1	3	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ACM5	M₅		Acetylcholine (muscarinic)	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	3	-	Gq/11	2	nc	2'	1'	nc	0	6	100	0	-	-	-	-	-	Gq	0	-	-	-	-	-	-	-	6	-	100	-	-	53	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ADA1A	α_1A		Adrenoceptors	A	-	Bouvier	GEMTA	3	12		noradrenaline	Phys	2	1	4	1	Gq/11	3	2'	3'	1'	nc	85	78	100	0	log(Emax/EC50)	6.6	6.1	7.8	0.0	G15	85	-	-	76	0	-	-	0	78	0	97	97	85	100	0	0	log(Emax/EC50)	6.6	-	-	5.9	0.0	-	-	0.0	6.1	0.0	7.6	7.5	6.6	7.8	0.0	0.0
ADA1A	α_1A		Adrenoceptors	A	-	Martemyanov	FreeGβγ-Nluc	2	5		(±)-adrenaline	Phys	2	1	4	1	Gq/11	2	2'	nc	1'	nc	21	0	100	0	Activation rate (s^-1)	0.3	0.0	1.3	0.0	Gq	21	-	-	-	-	-	-	-	0	-	100	-	-	29	-	0	Activation rate (s^-1)	0.3	-	-	-	-	-	-	-	0.0	-	1.3	-	-	0.4	-	0.0
ADA1A	α_1A		Adrenoceptors	A	-	Inoue	TGF𝛼	5	1		(-)-noradrenaline	Phys	2	1	4	1	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	8.0	-	-	-	-	-
ADA1A	α_1A		Adrenoceptors	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	2	1	4	1	Gq/11	2	-	-	1'	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ADA1A	α_1A		Adrenoceptors	A	-	GproteinDb	merged data	-	-	-	-	-	2	1	4	1	Gq/11	3	2'	3'	1'	nc	53	39	100	0	-	-	-	-	-	Gq	53	-	-	76	0	-	-	0	39	0	98	97	85	64	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ADA1B	α_1B		Adrenoceptors	A	-	Martemyanov	FreeGβγ-Nluc	2	5		(±)-adrenaline	Phys	-	-	3	-	Gq/11	1	nc	nc	1'	nc	0	0	100	0	Activation rate (s^-1)	0.0	0.0	0.5	0.0	G15	0	-	-	-	-	-	-	-	0	-	88	-	-	100	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.0	-	0.4	-	-	0.5	-	0.0
ADA1B	α_1B		Adrenoceptors	A	-	Inoue	TGF𝛼	5	1		(-)-noradrenaline	Phys	-	-	3	-	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	7.1	-	-	-	-	-
ADA1B	α_1B		Adrenoceptors	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	-	3	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ADA1B	α_1B		Adrenoceptors	A	-	GproteinDb	merged data	-	-	-	-	-	-	-	3	-	Gq/11	1	nc	nc	1'	nc	0	0	100	0	-	-	-	-	-	G15	0	-	-	-	-	-	-	-	0	-	88	-	-	100	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ADA1D	α_1D		Adrenoceptors	A	-	Martemyanov	FreeGβγ-Nluc	2	5		(±)-adrenaline	Phys	-	-	2	-	Gq/11	1	nc	nc	1'	nc	0	0	100	0	Activation rate (s^-1)	0.0	0.0	0.2	0.0	Gq	0	-	-	-	-	-	-	-	0	-	100	-	-	25	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.0	-	0.2	-	-	0.1	-	0.0
ADA1D	α_1D		Adrenoceptors	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	-	2	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ADA1D	α_1D		Adrenoceptors	A	-	GproteinDb	merged data	-	-	-	-	-	-	-	2	-	Gq/11	1	nc	nc	1'	nc	0	0	100	0	-	-	-	-	-	Gq	0	-	-	-	-	-	-	-	0	-	100	-	-	25	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ADA2A	α_2A		Adrenoceptors	A	-	Bouvier	GEMTA	3	12		noradrenaline	Phys	2	5	1	1	Gi/o	4	4'	1'	2'	3'	58	100	68	60	log(Emax/EC50)	5.3	9.1	6.2	5.5	Gz	58	-	-	93	91	-	-	100	91	96	50	49	49	68	57	60	log(Emax/EC50)	5.3	-	-	8.5	8.3	-	-	9.1	8.3	8.8	4.6	4.4	4.4	6.2	5.2	5.5
ADA2A	α_2A		Adrenoceptors	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	2	5	1	1	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Econstitutive	0.00	0.03	0.00	0.00	Gi1	0	-	-	100	-	-	-	-	-	-	0	-	-	-	0	-	Econstitutive	0.00	-	-	0.03	-	-	-	-	-	-	0.00	-	-	-	0.00	-
ADA2A	α_2A		Adrenoceptors	A	-	Lambert	RGB-GDP	0	6		noradrenaline	Phys	2	5	1	1	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Efficacy	0.00	0.10	0.00	0.00	Gi1	0	-	-	100	-	-	-	-	-	-	0	-	-	-	0	-	Efficacy	0.00	-	-	0.10	-	-	-	-	-	-	0.00	-	-	-	0.00	-
ADA2A	α_2A		Adrenoceptors	A	-	Martemyanov	FreeGβγ-Nluc	2	5		(±)-adrenaline	Phys	2	5	1	1	Gi/o	1	nc	1'	2'	nc	0	100	0	0	Activation rate (s^-1)	0.0	10.8	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	10.8	-	0.0	-	-	0.0	-	0.0
ADA2A	α_2A		Adrenoceptors	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	2	5	1	1	Gi/o	2	2'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ADA2A	α_2A		Adrenoceptors	A	-	GproteinDb	merged data	-	-	-	-	-	2	5	1	1	Gi/o	4	4'	1'	2'	3'	14	100	17	15	-	-	-	-	-	Gz	14	-	-	98	91	-	-	100	96	96	12	49	49	34	19	30	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ADA2B	α_2B		Adrenoceptors	A	-	Bouvier	GEMTA	3	12		noradrenaline	Phys	1	3	1	-	Gi/o	2	nc	1'	2'	nc	0	100	72	0	log(Emax/EC50)	0.0	8.2	5.9	0.0	Gz	0	-	-	92	87	-	-	100	93	99	0	0	0	72	0	0	log(Emax/EC50)	0.0	-	-	7.5	7.1	-	-	8.2	7.6	8.1	0.0	0.0	0.0	5.9	0.0	0.0
ADA2B	α_2B		Adrenoceptors	A	-	Martemyanov	FreeGβγ-Nluc	2	5		(±)-adrenaline	Phys	1	3	1	-	Gi/o	1	nc	1'	2'	nc	0	100	1	0	Activation rate (s^-1)	0.0	1.7	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	1	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	1.7	-	0.0	-	-	0.0	-	0.0
ADA2B	α_2B		Adrenoceptors	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	1	3	1	-	Gi/o	2	2'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ADA2B	α_2B		Adrenoceptors	A	-	GproteinDb	merged data	-	-	-	-	-	1	3	1	-	Gi/o	2	nc	1'	2'	nc	0	100	36	0	-	-	-	-	-	Gz	0	-	-	92	87	-	-	100	96	99	0	0	0	36	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ADA2C	α_2C		Adrenoceptors	A	-	Bouvier	GEMTA	3	12		noradrenaline	Phys	1	3	1	1	Gi/o	3	nc	1'	3'	2'	0	100	55	55	log(Emax/EC50)	0.0	9.5	5.2	5.3	Gz	0	-	-	90	88	-	-	100	93	98	0	0	0	55	0	55	log(Emax/EC50)	0.0	-	-	8.5	8.4	-	-	9.5	8.9	9.4	0.0	0.0	0.0	5.2	0.0	5.3
ADA2C	α_2C		Adrenoceptors	A	-	Martemyanov	FreeGβγ-Nluc	2	5		(±)-adrenaline	Phys	1	3	1	1	Gi/o	1	nc	1'	2'	nc	0	100	0	0	Activation rate (s^-1)	0.0	9.1	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	9.1	-	0.0	-	-	0.0	-	0.0
ADA2C	α_2C		Adrenoceptors	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	1	3	1	1	Gi/o	2	2'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ADA2C	α_2C		Adrenoceptors	A	-	GproteinDb	merged data	-	-	-	-	-	1	3	1	1	Gi/o	3	nc	1'	2'	3'	0	100	28	28	-	-	-	-	-	Gz	0	-	-	90	88	-	-	100	96	98	0	0	0	28	0	28	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ADRB1	β₁		Adrenoceptors	A	-	Bouvier	GEMTA	3	12		noradrenaline	Phys	3	3	2	1	Gs	4	1'	3'	2'	4'	100	64	85	57	log(Emax/EC50)	9.6	6.1	8.2	5.5	GsL	100	-	-	0	0	-	-	64	56	60	48	0	56	85	57	54	log(Emax/EC50)	9.6	-	-	0.0	0.0	-	-	6.1	5.4	5.8	4.6	0.0	5.4	8.2	5.5	5.2
ADRB1	β₁		Adrenoceptors	A	-	Martemyanov	FreeGβγ-Nluc	2	5		(±)-adrenaline	Phys	3	3	2	1	Gs	3	1'	3'	2'	nc	100	6	34	0	Activation rate (s^-1)	2.9	0.2	1.0	0.0	GsL	100	-	-	-	-	-	-	-	6	-	0	-	-	34	-	0	Activation rate (s^-1)	2.9	-	-	-	-	-	-	-	0.2	-	0.0	-	-	1.0	-	0.0
ADRB1	β₁		Adrenoceptors	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	3	3	2	1	Gs	2	1'	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ADRB1	β₁		Adrenoceptors	A	-	GproteinDb	merged data	-	-	-	-	-	3	3	2	1	Gs	4	1'	3'	2'	4'	100	35	60	28	-	-	-	-	-	GsL	100	-	-	0	0	-	-	64	31	60	24	0	56	60	57	27	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ADRB2	β₂		Adrenoceptors	A	-	Bouvier	GEMTA	3	12		noradrenaline	Phys	6	3	4	-	Gs	2	1'	nc	2'	nc	100	0	77	0	log(Emax/EC50)	8.2	0.0	6.3	0.0	GsL	100	-	-	0	0	-	-	0	0	0	0	0	0	77	0	0	log(Emax/EC50)	8.2	-	-	0.0	0.0	-	-	0.0	0.0	0.0	0.0	0.0	0.0	6.3	0.0	0.0
ADRB2	β₂		Adrenoceptors	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	6	3	4	-	Gs	1	1'	nc	nc	nc	100	0	0	0	Econstitutive	0.02	0.00	0.00	0.00	GsL	100	-	-	0	-	-	-	-	-	-	0	-	-	-	0	-	Econstitutive	0.02	-	-	0.00	-	-	-	-	-	-	0.00	-	-	-	0.00	-
ADRB2	β₂		Adrenoceptors	A	-	Lambert	RGB-GDP	0	6		noradrenaline	Phys	6	3	4	-	Gs	3	1'	2'	3'	nc	100	56	25	0	Efficacy	0.09	0.05	0.02	0.00	GsL	100	-	-	56	-	-	-	-	-	-	25	-	-	-	0	-	Efficacy	0.09	-	-	0.05	-	-	-	-	-	-	0.02	-	-	-	0.00	-
ADRB2	β₂		Adrenoceptors	A	-	Martemyanov	FreeGβγ-Nluc	2	5		(±)-adrenaline	Phys	6	3	4	-	Gs	2	1'	nc	2'	nc	100	0	11	0	Activation rate (s^-1)	2.1	0.0	0.2	0.0	GsL	100	-	-	-	-	-	-	-	0	-	0	-	-	11	-	0	Activation rate (s^-1)	2.1	-	-	-	-	-	-	-	0.0	-	0.0	-	-	0.2	-	0.0
ADRB2	β₂		Adrenoceptors	A	-	Roth	TRUPATH	1	15		(-)-adrenaline	Phys	6	3	4	-	Gs	3	1'	3'	2'	nc	100	8	11	0	log(Emax/EC50)	79.8	6.6	8.5	0.0	G15	80	76	80	0	78	0	0	64	64	70	0	0	-	100	0	0	log(Emax/EC50)	6.8	6.4	6.8	0.0	6.6	0.0	0.0	5.4	5.4	6.0	0.0	0.0	-	8.5	0.0	0.0
ADRB2	β₂		Adrenoceptors	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	6	3	4	-	Gs	2	1'	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ADRB2	β₂		Adrenoceptors	A	-	GproteinDb	merged data	-	-	-	-	-	6	3	4	-	Gs	3	1'	3'	2'	nc	100	13	25	0	-	-	-	-	-	GsL	96	76	80	14	39	0	0	32	21	35	5	0	0	63	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ADRB3	β₃		Adrenoceptors	A	-	Martemyanov	FreeGβγ-Nluc	2	5		(±)-adrenaline	Phys	2	1	1	-	Gs	2	1'	nc	2'	nc	100	0	18	0	Activation rate (s^-1)	0.5	0.0	0.1	0.0	GsL	100	-	-	-	-	-	-	-	0	-	0	-	-	18	-	0	Activation rate (s^-1)	0.5	-	-	-	-	-	-	-	0.0	-	0.0	-	-	0.1	-	0.0
ADRB3	β₃		Adrenoceptors	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	2	1	1	-	Gs	2	1'	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ADRB3	β₃		Adrenoceptors	A	-	GproteinDb	merged data	-	-	-	-	-	2	1	1	-	Gs	2	1'	nc	2'	nc	100	0	18	0	-	-	-	-	-	GsL	100	-	-	-	-	-	-	-	0	-	0	-	-	18	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DRD1	D₁		Dopamine	A	-	Bouvier	GEMTA	3	12		dopamine	Phys	5	2	2	-	Gs	3	1'	3'	2'	nc	100	61	86	0	log(Emax/EC50)	8.6	5.3	7.4	0.0	GsL	100	-	-	0	0	-	-	61	0	56	0	0	0	86	0	0	log(Emax/EC50)	8.6	-	-	0.0	0.0	-	-	5.3	0.0	4.8	0.0	0.0	0.0	7.4	0.0	0.0
DRD1	D₁		Dopamine	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	5	2	2	-	Gs	1	1'	nc	nc	nc	100	0	0	0	Econstitutive	0.03	0.00	0.00	0.00	GsL	100	-	-	0	-	-	-	-	-	-	0	-	-	-	0	-	Econstitutive	0.03	-	-	0.00	-	-	-	-	-	-	0.00	-	-	-	0.00	-
DRD1	D₁		Dopamine	A	-	Lambert	RGB-GDP	0	6		dopamine	Phys	5	2	2	-	Gs	2	1'	2'	nc	nc	100	71	0	0	Efficacy	0.05	0.04	0.00	0.00	GsL	100	-	-	71	-	-	-	-	-	-	0	-	-	-	0	-	Efficacy	0.05	-	-	0.04	-	-	-	-	-	-	0.00	-	-	-	0.00	-
DRD1	D₁		Dopamine	A	-	Martemyanov	FreeGβγ-Nluc	2	5		dopamine	Phys	5	2	2	-	Gs	2	1'	nc	2'	nc	100	0	18	0	Activation rate (s^-1)	1.1	0.0	0.2	0.0	GsL	100	-	-	-	-	-	-	-	0	-	0	-	-	18	-	0	Activation rate (s^-1)	1.1	-	-	-	-	-	-	-	0.0	-	0.0	-	-	0.2	-	0.0
DRD1	D₁		Dopamine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	5	2	2	-	Gs	1	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DRD1	D₁		Dopamine	A	-	GproteinDb	merged data	-	-	-	-	-	5	2	2	-	Gs	3	1'	2'	3'	nc	100	33	26	0	-	-	-	-	-	GsL	100	-	-	24	0	-	-	61	0	56	0	0	0	52	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DRD3	D₃		Dopamine	A	-	Martemyanov	FreeGβγ-Nluc	2	5		dopamine	Phys	-	2	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Activation rate (s^-1)	0.0	0.3	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.3	-	0.0	-	-	0.0	-	0.0
DRD3	D₃		Dopamine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	2	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DRD3	D₃		Dopamine	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	-	-	-	-	-	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DRD4	D₄		Dopamine	A	-	Martemyanov	FreeGβγ-Nluc	2	5		dopamine	Phys	-	2	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Activation rate (s^-1)	0.0	3.9	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	3.9	-	0.0	-	-	0.0	-	0.0
DRD4	D₄		Dopamine	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	2	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DRD4	D₄		Dopamine	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	-	-	-	-	-	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DRD5	D₅		Dopamine	A	-	Bouvier	GEMTA	3	12		dopamine	Phys	4	3	2	-	Gs	3	1'	3'	2'	nc	100	70	91	0	log(Emax/EC50)	8.4	5.9	7.7	0.0	GsL	100	-	-	60	55	-	-	0	0	70	0	0	0	91	0	0	log(Emax/EC50)	8.4	-	-	5.1	4.6	-	-	0.0	0.0	5.9	0.0	0.0	0.0	7.7	0.0	0.0
DRD5	D₅		Dopamine	A	-	Lambert	RGB-GDP	0	6	-	None (constitutive activity)	-	4	3	2	-	-	0	nc	nc	nc	nc	0	0	0	0	Econstitutive	0.00	0.00	0.00	0.00	-	0	-	-	0	-	-	-	-	-	-	0	-	-	-	0	-	Econstitutive	0.00	-	-	0.00	-	-	-	-	-	-	0.00	-	-	-	0.00	-
DRD5	D₅		Dopamine	A	-	Lambert	RGB-GDP	0	6	-	dopamine	Phys	4	3	2	-	Gs	2	1'	2'	nc	nc	100	65	0	0	Efficacy	0.02	0.02	0.00	0.00	GsL	100	-	-	65	-	-	-	-	-	-	0	-	-	-	0	-	Efficacy	0.02	-	-	0.02	-	-	-	-	-	-	0.00	-	-	-	0.00	-
DRD5	D₅		Dopamine	A	-	Martemyanov	FreeGβγ-Nluc	2	5		dopamine	Phys	4	3	2	-	Gs	3	1'	3'	2'	nc	100	14	41	0	Activation rate (s^-1)	1.6	0.2	0.6	0.0	GsL	100	-	-	-	-	-	-	-	14	-	0	-	-	41	-	0	Activation rate (s^-1)	1.6	-	-	-	-	-	-	-	0.2	-	0.0	-	-	0.6	-	0.0
DRD5	D₅		Dopamine	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	4	3	2	-	Gs	1	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
DRD5	D₅		Dopamine	A	-	GproteinDb	merged data	-	-	-	-	-	4	3	2	-	Gs	3	1'	2'	3'	nc	75	37	33	0	-	-	-	-	-	GsL	75	-	-	42	55	-	-	0	7	70	0	0	0	66	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HRH1	H₁		Histamine	A	-	Bouvier	GEMTA	3	12		histamine	Phys	2	3	6	2	Gq/11	4	4'	2'	1'	3'	68	83	100	71	log(Emax/EC50)	5.5	6.8	8.1	5.8	G15	68	-	-	79	75	-	-	83	73	75	92	95	95	100	71	67	log(Emax/EC50)	5.5	-	-	6.4	6.1	-	-	6.8	6.0	6.1	7.5	7.7	7.8	8.1	5.8	5.5
HRH1	H₁		Histamine	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	2	3	6	2	Gq/11	1	nc	nc	1'	nc	0	0	100	0	Econstitutive	0.00	0.00	0.01	0.00	Gq	0	-	-	0	-	-	-	-	-	-	100	-	-	-	0	-	Econstitutive	0.00	-	-	0.00	-	-	-	-	-	-	0.01	-	-	-	0.00	-
HRH1	H₁		Histamine	A	-	Lambert	RGB-GDP	0	6		histamine	Phys	2	3	6	2	Gq/11	3	3'	2'	1'	nc	28	96	100	0	Efficacy	0.02	0.07	0.08	0.00	Gq	28	-	-	96	-	-	-	-	-	-	100	-	-	-	0	-	Efficacy	0.02	-	-	0.07	-	-	-	-	-	-	0.08	-	-	-	0.00	-
HRH1	H₁		Histamine	A	-	Martemyanov	FreeGβγ-Nluc	2	5		histamine	Phys	2	3	6	2	Gq/11	3	nc	2'	1'	3'	0	30	100	12	Activation rate (s^-1)	0.0	0.4	1.3	0.1	Gq	0	-	-	-	-	-	-	-	30	-	100	-	-	46	-	12	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.4	-	1.3	-	-	0.6	-	0.1
HRH1	H₁		Histamine	A	-	Inoue	TGF𝛼	5	1		histamine	Phys	2	3	6	2	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	7.2	-	-	-	-	-
HRH1	H₁		Histamine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	2	3	6	2	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HRH1	H₁		Histamine	A	-	GproteinDb	merged data	-	-	-	-	-	2	3	6	2	Gq/11	4	3'	2'	1'	4'	24	52	100	21	-	-	-	-	-	Gq	24	-	-	58	75	-	-	83	52	75	98	95	95	73	24	40	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HRH2	H₂		Histamine	A	-	Bouvier	GEMTA	3	12		histamine	Phys	5	2	4	1	Gs	4	1'	4'	2'	3'	100	58	93	63	log(Emax/EC50)	7.0	4.1	6.5	4.4	GsL	100	-	-	0	0	-	-	46	58	58	0	0	0	93	58	63	log(Emax/EC50)	7.0	-	-	0.0	0.0	-	-	3.2	4.0	4.1	0.0	0.0	0.0	6.5	4.0	4.4
HRH2	H₂		Histamine	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	5	2	4	1	Gs	1	1'	nc	nc	nc	100	0	0	0	Econstitutive	0.07	0.00	0.00	0.00	GsL	100	-	-	0	-	-	-	-	-	-	0	-	-	-	0	-	Econstitutive	0.07	-	-	0.00	-	-	-	-	-	-	0.00	-	-	-	0.00	-
HRH2	H₂		Histamine	A	-	Lambert	RGB-GDP	0	6		amthamine	Surr	5	2	4	1	Gs	3	1'	2'	3'	nc	100	24	20	0	Efficacy	0.08	0.02	0.02	0.00	GsL	100	-	-	24	-	-	-	-	-	-	20	-	-	-	0	-	Efficacy	0.08	-	-	0.02	-	-	-	-	-	-	0.02	-	-	-	0.00	-
HRH2	H₂		Histamine	A	-	Martemyanov	FreeGβγ-Nluc	2	5		histamine	Phys	5	2	4	1	Gs	2	1'	nc	2'	nc	100	0	33	0	Activation rate (s^-1)	1.6	0.0	0.5	0.0	GsL	100	-	-	-	-	-	-	-	0	-	0	-	-	33	-	0	Activation rate (s^-1)	1.6	-	-	-	-	-	-	-	0.0	-	0.0	-	-	0.5	-	0.0
HRH2	H₂		Histamine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	5	2	4	1	Gq/11	2	2'	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HRH2	H₂		Histamine	A	-	GproteinDb	merged data	-	-	-	-	-	5	2	4	1	Gs	4	1'	3'	2'	4'	100	20	36	16	-	-	-	-	-	GsL	100	-	-	8	0	-	-	46	29	58	5	0	0	63	19	32	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HRH3	H₃		Histamine	A	-	Martemyanov	FreeGβγ-Nluc	2	5		histamine	Phys	-	2	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Activation rate (s^-1)	0.0	2.3	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	2.3	-	0.0	-	-	0.0	-	0.0
HRH3	H₃		Histamine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	2	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HRH3	H₃		Histamine	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	-	-	-	-	-	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HRH4	H₄		Histamine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HRH4	H₄		Histamine	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TAAR1	TA₁		Trace amine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	1	-	1	-	Gs	2	1'	-	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TAAR1	TA₁		Trace amine	A	-	GproteinDb	merged data	-	-	-	-	-	1	-	1	-	Gs	2	1'	-	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
AGTR1	AT₁		Angiotensin	A	-	Bouvier	GEMTA	3	12		angiotensin II	Phys	-	3	4	1	Gq/11	3	nc	3'	1'	2'	0	79	100	96	log(Emax/EC50)	0.0	7.1	9.0	8.6	G11	0	-	-	77	76	-	-	71	79	77	97	100	91	92	93	96	log(Emax/EC50)	0.0	-	-	6.9	6.8	-	-	6.4	7.1	6.9	8.7	9.0	8.2	8.2	8.3	8.6
AGTR1	AT₁		Angiotensin	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	-	3	4	1	-	0	nc	nc	nc	nc	0	0	0	0	Econstitutive	0.00	0.00	0.00	0.00	-	0	-	-	0	-	-	-	-	-	-	0	-	-	-	0	-	Econstitutive	0.00	-	-	0.00	-	-	-	-	-	-	0.00	-	-	-	0.00	-
AGTR1	AT₁		Angiotensin	A	-	Lambert	RGB-GDP	0	6		angiotensin II	Phys	-	3	4	1	Gq/11	2	nc	2'	1'	nc	0	58	100	0	Efficacy	0.00	0.03	0.05	0.00	Gq	0	-	-	58	-	-	-	-	-	-	100	-	-	-	0	-	Efficacy	0.00	-	-	0.03	-	-	-	-	-	-	0.05	-	-	-	0.00	-
AGTR1	AT₁		Angiotensin	A	-	Inoue	TGF𝛼	5	1		angiotensin II	Phys	-	3	4	1	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	10.0	-	-	-	-	-
AGTR1	AT₁		Angiotensin	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	3	4	1	Gi/o	2	-	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
AGTR1	AT₁		Angiotensin	A	-	GproteinDb	merged data	-	-	-	-	-	-	3	4	1	Gq/11	3	nc	2'	1'	3'	0	46	67	32	-	-	-	-	-	G11	0	-	-	45	76	-	-	71	79	77	66	100	91	92	31	96	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
AGTR2	AT₂		Angiotensin	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
AGTR2	AT₂		Angiotensin	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
APJ	Apelin		Apelin	A	-	Bouvier	GEMTA	3	12		[Pyr¹]apelin-13	Phys	-	3	1	1	Gi/o	3	nc	1'	3'	2'	0	100	63	72	log(Emax/EC50)	0.0	9.3	5.8	6.7	Gi1	0	-	-	100	99	-	-	85	94	96	0	0	0	63	72	64	log(Emax/EC50)	0.0	-	-	9.3	9.2	-	-	7.9	8.7	8.9	0.0	0.0	0.0	5.8	6.7	5.9
APJ	Apelin		Apelin	A	-	Martemyanov	FreeGβγ-Nluc	2	5		apelin-17	Phys	-	3	1	1	Gi/o	1	nc	1'	2'	nc	0	100	0	0	Activation rate (s^-1)	0.0	5.8	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	5.8	-	0.0	-	-	0.0	-	0.0
APJ	Apelin		Apelin	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	3	1	1	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
APJ	Apelin		Apelin	A	-	GproteinDb	merged data	-	-	-	-	-	-	3	1	1	Gi/o	3	nc	1'	3'	2'	0	100	32	36	-	-	-	-	-	Gi1	0	-	-	100	99	-	-	85	97	96	0	0	0	32	72	32	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NMBR	BB₁		Bombesin	A	-	Inoue	TGF𝛼	5	1		neuromedin B	Phys	-	-	2	-	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	10.4	-	-	-	-	-
NMBR	BB₁		Bombesin	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	-	2	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NMBR	BB₁		Bombesin	A	-	GproteinDb	merged data	-	-	-	-	-	-	-	2	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GRPR	BB₂		Bombesin	A	-	Martemyanov	FreeGβγ-Nluc	2	5		gastrin-releasing peptide	Phys	-	1	3	1	Gq/11	3	nc	3'	1'	2'	0	2	100	6	Activation rate (s^-1)	0.0	0.1	4.6	0.3	Gq	0	-	-	-	-	-	-	-	2	-	100	-	-	0	-	6	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.1	-	4.6	-	-	0.0	-	0.3
GRPR	BB₂		Bombesin	A	-	Inoue	TGF𝛼	5	1		bombesin	Phys	-	1	3	1	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	9.9	-	-	-	-	-
GRPR	BB₂		Bombesin	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	1	3	1	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GRPR	BB₂		Bombesin	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	3	1	Gq/11	3	nc	3'	1'	2'	0	2	100	6	-	-	-	-	-	Gq	0	-	-	-	-	-	-	-	2	-	100	-	-	0	-	6	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
BRS3	BB₃		Bombesin	A	-	Martemyanov	FreeGβγ-Nluc	2	5		[125I][D-Tyr6,β-Ala11,Phe13,Nle14]bombesin-(6-14)	Phys	-	-	2	-	Gq/11	1	nc	nc	1'	nc	0	0	100	0	Activation rate (s^-1)	0.0	0.0	0.1	0.0	Gq	0	-	-	-	-	-	-	-	0	-	100	-	-	0	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.0	-	0.1	-	-	0.0	-	0.0
BRS3	BB₃		Bombesin	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	-	2	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
BRS3	BB₃		Bombesin	A	-	GproteinDb	merged data	-	-	-	-	-	-	-	2	-	Gq/11	1	nc	nc	1'	nc	0	0	100	0	-	-	-	-	-	Gq	0	-	-	-	-	-	-	-	0	-	100	-	-	0	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
BKRB1	B₁		Bradykinin	A	-	Bouvier	GEMTA	3	12		kallidin	Phys	-	2	3	-	Gq/11	2	nc	2'	1'	nc	0	94	100	0	log(Emax/EC50)	0.0	6.0	6.4	0.0	G15	0	-	-	88	88	-	-	85	88	94	95	95	95	100	0	0	log(Emax/EC50)	0.0	-	-	5.7	5.6	-	-	5.5	5.6	6.0	6.1	6.1	6.1	6.4	0.0	0.0
BKRB1	B₁		Bradykinin	A	-	Inoue	TGF𝛼	5	1		bradykinin	Phys	-	2	3	-	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	7.5	-	-	-	-	-
BKRB1	B₁		Bradykinin	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	2	3	-	Gi/o	2	-	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
BKRB1	B₁		Bradykinin	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	3	-	Gq/11	2	nc	2'	1'	nc	0	94	100	0	-	-	-	-	-	G15	0	-	-	88	88	-	-	85	88	94	95	95	95	100	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
BKRB2	B₂		Bradykinin	A	-	Bouvier	GEMTA	3	12		kallidin	Phys	1	3	4	2	Gq/11	3	nc	3'	1'	2'	0	85	100	98	log(Emax/EC50)	0.0	8.0	9.4	9.2	Gq	0	-	-	83	77	-	-	85	75	82	100	100	100	93	98	95	log(Emax/EC50)	0.0	-	-	7.9	7.3	-	-	8.0	7.0	7.7	9.4	9.4	9.4	8.7	9.2	9.0
BKRB2	B₂		Bradykinin	A	-	Martemyanov	FreeGβγ-Nluc	2	5		bradykinin	Phys	1	3	4	2	Gq/11	3	nc	3'	1'	2'	0	3	100	8	Activation rate (s^-1)	0.0	0.2	4.4	0.4	Gq	0	-	-	-	-	-	-	-	3	-	100	-	-	4	-	8	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.2	-	4.4	-	-	0.2	-	0.4
BKRB2	B₂		Bradykinin	A	-	Inoue	TGF𝛼	5	1		kallidin	Phys	1	3	4	2	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	9.8	-	-	-	-	-
BKRB2	B₂		Bradykinin	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	1	3	4	2	Gq/11	3	1'	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
BKRB2	B₂		Bradykinin	A	-	GproteinDb	merged data	-	-	-	-	-	1	3	4	2	Gq/11	3	nc	3'	1'	2'	0	44	100	53	-	-	-	-	-	Gq	0	-	-	83	77	-	-	85	39	82	100	100	100	48	98	52	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CCKAR	CCK₁		Cholecystokinin	A	-	Bouvier	GEMTA	3	12		CCK-8	Phys	3	2	4	2	G12/13	4	4'	3'	2'	1'	83	88	99	100	log(Emax/EC50)	8.1	8.5	9.7	9.7	G12	83	-	-	87	84	-	-	80	88	87	96	98	99	90	100	94	log(Emax/EC50)	8.1	-	-	8.4	8.2	-	-	7.8	8.5	8.5	9.4	9.6	9.7	8.8	9.7	9.2
CCKAR	CCK₁		Cholecystokinin	A	-	Martemyanov	FreeGβγ-Nluc	2	5		CCK-8	Phys	3	2	4	2	Gq/11	4	4'	2'	1'	3'	5	78	100	18	Activation rate (s^-1)	0.2	3.2	4.1	0.7	Gq	5	-	-	-	-	-	-	-	78	-	100	-	-	14	-	18	Activation rate (s^-1)	0.2	-	-	-	-	-	-	-	3.2	-	4.1	-	-	0.6	-	0.7
CCKAR	CCK₁		Cholecystokinin	A	-	Inoue	TGF𝛼	5	1		CCK-8	Phys	3	2	4	2	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	10.5	-	-	-	-	-
CCKAR	CCK₁		Cholecystokinin	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	3	2	4	2	Gq/11	2	2'	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CCKAR	CCK₁		Cholecystokinin	A	-	GproteinDb	merged data	-	-	-	-	-	3	2	4	2	Gq/11	4	4'	2'	1'	3'	44	83	100	59	-	-	-	-	-	G12	44	-	-	87	84	-	-	80	83	87	98	98	99	52	100	56	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GASR	CCK₂		Cholecystokinin	A	-	Martemyanov	FreeGβγ-Nluc	2	5		CCK-8	Phys	-	1	3	1	Gq/11	3	nc	2'	1'	3'	0	34	100	12	Activation rate (s^-1)	0.0	1.4	4.1	0.5	Gq	0	-	-	-	-	-	-	-	34	-	100	-	-	29	-	12	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	1.4	-	4.1	-	-	1.2	-	0.5
GASR	CCK₂		Cholecystokinin	A	-	Inoue	TGF𝛼	5	1		CCK-8	Phys	-	1	3	1	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	10.0	-	-	-	-	-
GASR	CCK₂		Cholecystokinin	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	1	3	1	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GASR	CCK₂		Cholecystokinin	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	3	1	Gq/11	3	nc	2'	1'	3'	0	34	100	12	-	-	-	-	-	Gq	0	-	-	-	-	-	-	-	34	-	100	-	-	29	-	12	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
C5AR1	C5a₁		Complement peptide	A	-	Bouvier	GEMTA	3	12		C5a	Phys	-	4	2	-	Gq/11	2	nc	2'	1'	nc	0	99	100	0	log(Emax/EC50)	0.0	9.2	9.3	0.0	G15	0	-	-	98	99	-	-	88	92	98	0	0	0	100	0	0	log(Emax/EC50)	0.0	-	-	9.1	9.2	-	-	8.1	8.5	9.1	0.0	0.0	0.0	9.3	0.0	0.0
C5AR1	C5a₁		Complement peptide	A	-	Lambert	RGB-GDP	0	6	-	None (constitutive activity)	-	-	4	2	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Econstitutive	0.00	0.03	0.00	0.00	Gi1	0	-	-	100	-	-	-	-	-	-	0	-	-	-	0	-	Econstitutive	0.00	-	-	0.03	-	-	-	-	-	-	0.00	-	-	-	0.00	-
C5AR1	C5a₁		Complement peptide	A	-	Lambert	RGB-GDP	0	6	-	C5a	Phys	-	4	2	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Efficacy	0.00	0.05	0.00	0.00	Gi1	0	-	-	100	-	-	-	-	-	-	0	-	-	-	0	-	Efficacy	0.00	-	-	0.05	-	-	-	-	-	-	0.00	-	-	-	0.00	-
C5AR1	C5a₁		Complement peptide	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	4	2	-	Gi/o	2	-	1'	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
C5AR1	C5a₁		Complement peptide	A	-	GproteinDb	merged data	-	-	-	-	-	-	4	2	-	Gi/o	2	nc	1'	2'	nc	0	100	33	0	-	-	-	-	-	G15	0	-	-	99	99	-	-	88	92	98	0	0	0	100	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EDNRA	ET_A		Endothelin	A	-	Bouvier	GEMTA	3	12		endothelin-1	Phys	1	3	5	3	G12/13	4	4'	2'	3'	1'	78	96	93	100	log(Emax/EC50)	8.1	9.9	9.6	10.3	G12	78	-	-	90	90	-	-	96	91	93	92	91	93	79	100	92	log(Emax/EC50)	8.1	-	-	9.3	9.3	-	-	9.9	9.4	9.6	9.5	9.5	9.6	8.2	10.3	9.6
EDNRA	ET_A		Endothelin	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	1	3	5	3	-	0	nc	nc	nc	nc	0	0	0	0	Econstitutive	0.00	0.00	0.00	0.00	-	0	-	-	0	-	-	-	-	-	-	0	-	-	-	0	-	Econstitutive	0.00	-	-	0.00	-	-	-	-	-	-	0.00	-	-	-	0.00	-
EDNRA	ET_A		Endothelin	A	-	Lambert	RGB-GDP	0	6		endothelin-1	Phys	1	3	5	3	Gi/o	3	nc	1'	2'	3'	0	100	94	36	Efficacy	0.00	0.06	0.06	0.02	Gi1	0	-	-	100	-	-	-	-	-	-	94	-	-	-	36	-	Efficacy	0.00	-	-	0.06	-	-	-	-	-	-	0.06	-	-	-	0.02	-
EDNRA	ET_A		Endothelin	A	-	Martemyanov	FreeGβγ-Nluc	2	5		endothelin-2	Phys	1	3	5	3	Gi/o	3	nc	1'	2'	3'	0	100	40	18	Activation rate (s^-1)	0.0	0.5	0.2	0.1	GoA	0	-	-	-	-	-	-	-	100	-	40	-	-	0	-	18	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.5	-	0.2	-	-	0.0	-	0.1
EDNRA	ET_A		Endothelin	A	-	Inoue	TGF𝛼	5	1		endothelin-1	Phys	1	3	5	3	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	10.0	-	-	-	-	-
EDNRA	ET_A		Endothelin	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	1	3	5	3	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EDNRA	ET_A		Endothelin	A	-	GproteinDb	merged data	-	-	-	-	-	1	3	5	3	Gi/o	4	4'	1'	2'	3'	20	74	57	38	-	-	-	-	-	Gz	20	-	-	63	90	-	-	96	96	93	56	91	93	40	45	55	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EDNRB	ET_B		Endothelin	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	1	3	4	2	-	0	nc	nc	nc	nc	0	0	0	0	Econstitutive	0.00	0.00	0.00	0.00	-	0	-	-	0	-	-	-	-	-	-	0	-	-	-	0	-	Econstitutive	0.00	-	-	0.00	-	-	-	-	-	-	0.00	-	-	-	0.00	-
EDNRB	ET_B		Endothelin	A	-	Lambert	RGB-GDP	0	6		endothelin-1	Phys	1	3	4	2	Gi/o	3	nc	1'	2'	3'	0	100	54	12	Efficacy	0.00	0.09	0.05	0.01	Gi1	0	-	-	100	-	-	-	-	-	-	54	-	-	-	12	-	Efficacy	0.00	-	-	0.09	-	-	-	-	-	-	0.05	-	-	-	0.01	-
EDNRB	ET_B		Endothelin	A	-	Martemyanov	FreeGβγ-Nluc	2	5		endothelin-2	Phys	1	3	4	2	Gi/o	3	nc	1'	2'	3'	0	100	24	20	Activation rate (s^-1)	0.0	10.2	2.4	2.0	GoA	0	-	-	-	-	-	-	-	100	-	24	-	-	0	-	20	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	10.2	-	2.4	-	-	0.0	-	2.0
EDNRB	ET_B		Endothelin	A	-	Inoue	TGF𝛼	5	1		endothelin-1	Phys	1	3	4	2	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	9.4	-	-	-	-	-
EDNRB	ET_B		Endothelin	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	1	3	4	2	Gs	3	1'	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
EDNRB	ET_B		Endothelin	A	-	GproteinDb	merged data	-	-	-	-	-	1	3	4	2	Gi/o	3	nc	1'	2'	3'	0	67	26	11	-	-	-	-	-	GoA	0	-	-	50	-	-	-	-	100	-	26	-	-	0	6	20	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
FPR1	FPR1		Formylpeptide	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	-	3	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Econstitutive	0.00	0.07	0.00	0.00	Gi1	0	-	-	100	-	-	-	-	-	-	0	-	-	-	0	-	Econstitutive	0.00	-	-	0.07	-	-	-	-	-	-	0.00	-	-	-	0.00	-
FPR1	FPR1		Formylpeptide	A	-	Lambert	RGB-GDP	0	6		WKYMVM	Surr	-	3	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Efficacy	0.00	0.12	0.00	0.00	Gi1	0	-	-	100	-	-	-	-	-	-	0	-	-	-	0	-	Efficacy	0.00	-	-	0.12	-	-	-	-	-	-	0.00	-	-	-	0.00	-
FPR1	FPR1		Formylpeptide	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	3	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
FPR1	FPR1		Formylpeptide	A	-	GproteinDb	merged data	-	-	-	-	-	-	3	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	-	-	-	-	-	Gi1	0	-	-	100	-	-	-	-	-	-	0	-	-	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
FPR2	FPR2/ALX		Formylpeptide	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	-	3	1	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Econstitutive	0.00	0.05	0.00	0.00	Gi1	0	-	-	100	-	-	-	-	-	-	0	-	-	-	0	-	Econstitutive	0.00	-	-	0.05	-	-	-	-	-	-	0.00	-	-	-	0.00	-
FPR2	FPR2/ALX		Formylpeptide	A	-	Lambert	RGB-GDP	0	6		WKYMVM	Surr	-	3	1	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Efficacy	0.00	0.09	0.00	0.00	Gi1	0	-	-	100	-	-	-	-	-	-	0	-	-	-	0	-	Efficacy	0.00	-	-	0.09	-	-	-	-	-	-	0.00	-	-	-	0.00	-
FPR2	FPR2/ALX		Formylpeptide	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	3	1	-	Gi/o	2	-	1'	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
FPR2	FPR2/ALX		Formylpeptide	A	-	GproteinDb	merged data	-	-	-	-	-	-	3	1	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	-	-	-	-	-	Gi1	0	-	-	100	-	-	-	-	-	-	0	-	-	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
FPR3	FPR3		Formylpeptide	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
FPR3	FPR3		Formylpeptide	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GALR1	GAL₁		Galanin	A	-	Martemyanov	FreeGβγ-Nluc	2	5		galanin	Phys	-	2	-	-	Gi/o	1	nc	1'	2'	nc	0	100	0	0	Activation rate (s^-1)	0.0	6.0	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	6.0	-	0.0	-	-	0.0	-	0.0
GALR1	GAL₁		Galanin	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	2	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GALR1	GAL₁		Galanin	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	-	-	-	-	-	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GALR2	GAL₂		Galanin	A	-	Martemyanov	FreeGβγ-Nluc	2	5		galanin	Phys	-	2	3	2	Gq/11	3	nc	3'	1'	2'	0	11	100	17	Activation rate (s^-1)	0.0	0.1	1.1	0.2	Gq	0	-	-	-	-	-	-	-	11	-	100	-	-	7	-	17	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.1	-	1.1	-	-	0.1	-	0.2
GALR2	GAL₂		Galanin	A	-	Inoue	TGF𝛼	5	1		galanin	Phys	-	2	3	2	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	8.1	-	-	-	-	-
GALR2	GAL₂		Galanin	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	2	3	2	Gq/11	3	-	2'	1'	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GALR2	GAL₂		Galanin	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	3	2	Gq/11	3	nc	3'	1'	2'	0	11	100	17	-	-	-	-	-	Gq	0	-	-	-	-	-	-	-	11	-	100	-	-	7	-	17	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GALR3	GAL₃		Galanin	A	-	Martemyanov	FreeGβγ-Nluc	2	5		galanin	Phys	-	2	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Activation rate (s^-1)	0.0	0.1	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.1	-	0.0	-	-	0.0	-	0.0
GALR3	GAL₃		Galanin	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	2	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GALR3	GAL₃		Galanin	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	-	-	-	-	-	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GHSR	Ghrelin		Ghrelin	A	-	Bouvier	GEMTA	3	12		ghrelin	Phys	-	2	3	2	G12/13	3	nc	3'	2'	1'	0	88	90	100	log(Emax/EC50)	0.0	8.2	8.3	9.3	G12	0	-	-	85	82	-	-	88	85	88	90	88	89	89	100	90	log(Emax/EC50)	0.0	-	-	7.9	7.7	-	-	8.2	7.9	8.2	8.3	8.2	8.3	8.3	9.3	8.4
GHSR	Ghrelin		Ghrelin	A	-	Inoue	TGF𝛼	5	1		ibutamoren	Surr	-	2	3	2	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	9.2	-	-	-	-	-
GHSR	Ghrelin		Ghrelin	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	2	3	2	Gq/11	3	-	2'	1'	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GHSR	Ghrelin		Ghrelin	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	3	2	G12/13	3	nc	3'	2'	1'	0	88	90	100	-	-	-	-	-	G12	0	-	-	85	82	-	-	88	85	88	90	88	89	89	100	90	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GNRHR	GnRH₁		Gonadotrophin-releasing hormone	A	-	Bouvier	GEMTA	3	12		GnRH I	Phys	-	1	3	-	Gq/11	1	nc	nc	1'	nc	0	0	100	0	log(Emax/EC50)	0.0	0.0	8.9	0.0	Gq	0	-	-	0	0	-	-	0	0	0	100	100	92	94	0	0	log(Emax/EC50)	0.0	-	-	0.0	0.0	-	-	0.0	0.0	0.0	8.9	8.9	8.2	8.3	0.0	0.0
GNRHR	GnRH₁		Gonadotrophin-releasing hormone	A	-	Inoue	TGF𝛼	5	1		leuprolide	Surr	-	1	3	-	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	9.1	-	-	-	-	-
GNRHR	GnRH₁		Gonadotrophin-releasing hormone	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	1	3	-	Gq/11	2	-	2'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GNRHR	GnRH₁		Gonadotrophin-releasing hormone	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	3	-	Gq/11	1	nc	nc	1'	nc	0	0	100	0	-	-	-	-	-	Gq	0	-	-	0	0	-	-	0	0	0	100	100	92	94	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
KISSR	Kisspeptin		Kisspeptin	A	-	Martemyanov	FreeGβγ-Nluc	2	5		kisspeptin-10	Phys	-	-	3	-	Gq/11	1	nc	nc	1'	nc	0	0	100	0	Activation rate (s^-1)	0.0	0.0	1.8	0.0	Gq	0	-	-	-	-	-	-	-	0	-	100	-	-	29	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.0	-	1.8	-	-	0.5	-	0.0
KISSR	Kisspeptin		Kisspeptin	A	-	Inoue	TGF𝛼	5	1		kisspeptin-10	Phys	-	-	3	-	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	8.9	-	-	-	-	-
KISSR	Kisspeptin		Kisspeptin	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	-	3	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
KISSR	Kisspeptin		Kisspeptin	A	-	GproteinDb	merged data	-	-	-	-	-	-	-	3	-	Gq/11	1	nc	nc	1'	nc	0	0	100	0	-	-	-	-	-	Gq	0	-	-	-	-	-	-	-	0	-	100	-	-	29	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MCHR1	MCH₁		Melanin-concentrating hormone	A	-	Inoue	TGF𝛼	5	1		melanin-concentrating hormone	Phys	1	1	2	-	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	8.2	-	-	-	-	-
MCHR1	MCH₁		Melanin-concentrating hormone	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	1	1	2	-	Gi/o	3	1'	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MCHR1	MCH₁		Melanin-concentrating hormone	A	-	GproteinDb	merged data	-	-	-	-	-	1	1	2	-	Gi/o	3	1'	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MCHR2	MCH₂		Melanin-concentrating hormone	A	-	Inoue	TGF𝛼	5	1		melanin-concentrating hormone	Phys	-	-	2	-	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	8.4	-	-	-	-	-
MCHR2	MCH₂		Melanin-concentrating hormone	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	-	2	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MCHR2	MCH₂		Melanin-concentrating hormone	A	-	GproteinDb	merged data	-	-	-	-	-	-	-	2	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MSHR	MC₁		Melanocortin	A	-	Martemyanov	FreeGβγ-Nluc	2	5		α-MSH	Phys	2	-	-	-	Gs	1	1'	nc	2'	nc	100	0	5	0	Activation rate (s^-1)	0.5	0.0	0.0	0.0	GsL	100	-	-	-	-	-	-	-	0	-	0	-	-	5	-	0	Activation rate (s^-1)	0.5	-	-	-	-	-	-	-	0.0	-	0.0	-	-	0.0	-	0.0
MSHR	MC₁		Melanocortin	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	2	-	-	-	Gs	1	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MSHR	MC₁		Melanocortin	A	-	GproteinDb	merged data	-	-	-	-	-	2	-	-	-	Gs	2	1'	nc	2'	nc	100	0	5	0	-	-	-	-	-	GsL	100	-	-	-	-	-	-	-	0	-	0	-	-	5	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ACTHR	MC₂		Melanocortin	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	1	-	-	-	Gs	1	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
ACTHR	MC₂		Melanocortin	A	-	GproteinDb	merged data	-	-	-	-	-	1	-	-	-	Gs	1	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MC3R	MC₃		Melanocortin	A	-	Bouvier	GEMTA	3	12		γ-MSH	Phys	3	1	3	1	Gq/11	4	2'	3'	1'	4'	92	75	100	61	log(Emax/EC50)	9.5	7.8	10.3	6.3	G15	92	-	-	0	0	-	-	75	0	67	0	0	0	100	61	60	log(Emax/EC50)	9.5	-	-	0.0	0.0	-	-	7.8	0.0	6.9	0.0	0.0	0.0	10.3	6.3	6.2
MC3R	MC₃		Melanocortin	A	-	Martemyanov	FreeGβγ-Nluc	2	5		α-MSH	Phys	3	1	3	1	Gs	2	1'	nc	2'	nc	100	0	94	0	Activation rate (s^-1)	0.1	0.0	0.1	0.0	GsL	100	-	-	-	-	-	-	-	0	-	0	-	-	94	-	0	Activation rate (s^-1)	0.1	-	-	-	-	-	-	-	0.0	-	0.0	-	-	0.1	-	0.0
MC3R	MC₃		Melanocortin	A	-	Inoue	TGF𝛼	5	1		α-MSH	Phys	3	1	3	1	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	7.5	-	-	-	-	-
MC3R	MC₃		Melanocortin	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	3	1	3	1	Gs	1	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MC3R	MC₃		Melanocortin	A	-	GproteinDb	merged data	-	-	-	-	-	3	1	3	1	Gq/11	4	2'	3'	1'	4'	96	38	97	30	-	-	-	-	-	G15	96	-	-	0	0	-	-	75	0	67	0	0	0	97	61	30	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MC4R	MC₄		Melanocortin	A	-	Bouvier	GEMTA	3	12		α-MSH	Phys	3	2	2	1	Gq/11	4	2'	3'	1'	4'	99	71	100	59	log(Emax/EC50)	7.9	5.7	8.1	4.7	G15	99	-	-	0	0	-	-	71	0	0	0	0	0	100	0	59	log(Emax/EC50)	7.9	-	-	0.0	0.0	-	-	5.7	0.0	0.0	0.0	0.0	0.0	8.1	0.0	4.7
MC4R	MC₄		Melanocortin	A	-	Martemyanov	FreeGβγ-Nluc	2	5		α-MSH	Phys	3	2	2	1	Gs	3	1'	2'	3'	nc	100	43	25	0	Activation rate (s^-1)	0.5	0.2	0.1	0.0	GsL	100	-	-	-	-	-	-	-	43	-	0	-	-	25	-	0	Activation rate (s^-1)	0.5	-	-	-	-	-	-	-	0.2	-	0.0	-	-	0.1	-	0.0
MC4R	MC₄		Melanocortin	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	3	2	2	1	Gs	1	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MC4R	MC₄		Melanocortin	A	-	GproteinDb	merged data	-	-	-	-	-	3	2	2	1	Gs	4	1'	3'	2'	4'	100	57	62	30	-	-	-	-	-	GsL	100	-	-	0	0	-	-	71	22	0	0	0	0	62	0	30	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MC5R	MC₅		Melanocortin	A	-	Martemyanov	FreeGβγ-Nluc	2	5		α-MSH	Phys	2	-	1	-	Gq/11	2	2'	nc	1'	nc	97	0	100	0	Activation rate (s^-1)	0.1	0.0	0.2	0.0	G15	97	-	-	-	-	-	-	-	0	-	62	-	-	100	-	0	Activation rate (s^-1)	0.1	-	-	-	-	-	-	-	0.0	-	0.1	-	-	0.2	-	0.0
MC5R	MC₅		Melanocortin	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	2	-	1	-	Gs	1	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MC5R	MC₅		Melanocortin	A	-	GproteinDb	merged data	-	-	-	-	-	2	-	1	-	Gq/11	2	2'	nc	1'	nc	97	0	100	0	-	-	-	-	-	G15	97	-	-	-	-	-	-	-	0	-	62	-	-	100	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MTLR	Motilin		Motilin	A	-	Inoue	TGF𝛼	5	1		motilin	Phys	-	-	2	1	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	9.7	-	-	-	-	-
MTLR	Motilin		Motilin	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	-	2	1	Gq/11	2	-	-	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
MTLR	Motilin		Motilin	A	-	GproteinDb	merged data	-	-	-	-	-	-	-	2	1	Gq/11	2	-	-	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NMUR1	NMU1		Neuromedin U	A	-	Inoue	TGF𝛼	5	1		neuromedin U-25	Phys	-	-	2	-	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	8.6	-	-	-	-	-
NMUR1	NMU1		Neuromedin U	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	-	2	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NMUR1	NMU1		Neuromedin U	A	-	GproteinDb	merged data	-	-	-	-	-	-	-	2	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NMUR2	NMU2		Neuromedin U	A	-	Inoue	TGF𝛼	5	1		neuromedin U-25	Phys	-	-	2	-	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	8.9	-	-	-	-	-
NMUR2	NMU2		Neuromedin U	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	-	2	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NMUR2	NMU2		Neuromedin U	A	-	GproteinDb	merged data	-	-	-	-	-	-	-	2	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NPFF1	NPFF1		Neuropeptide FF/neuropeptide AF	A	-	Bouvier	GEMTA	3	12		RFRP-3	Phys	-	3	1	1	Gi/o	3	nc	1'	2'	3'	0	100	76	69	log(Emax/EC50)	0.0	9.4	7.1	6.5	Gz	0	-	-	85	83	-	-	100	88	94	0	0	0	76	65	69	log(Emax/EC50)	0.0	-	-	7.9	7.8	-	-	9.4	8.2	8.8	0.0	0.0	0.0	7.1	6.1	6.5
NPFF1	NPFF1		Neuropeptide FF/neuropeptide AF	A	-	Martemyanov	FreeGβγ-Nluc	2	5		neuropeptide FF	Phys	-	3	1	1	Gi/o	1	nc	1'	2'	nc	0	100	2	0	Activation rate (s^-1)	0.0	1.0	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	2	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	1.0	-	0.0	-	-	0.0	-	0.0
NPFF1	NPFF1		Neuropeptide FF/neuropeptide AF	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	3	1	1	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NPFF1	NPFF1		Neuropeptide FF/neuropeptide AF	A	-	GproteinDb	merged data	-	-	-	-	-	-	3	1	1	Gi/o	3	nc	1'	2'	3'	0	100	39	34	-	-	-	-	-	Gz	0	-	-	85	83	-	-	100	94	94	0	0	0	39	65	34	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NPFF2	NPFF2		Neuropeptide FF/neuropeptide AF	A	-	Bouvier	GEMTA	3	12		neuropeptide FF	Phys	-	2	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	log(Emax/EC50)	0.0	7.7	0.0	0.0	Gz	0	-	-	84	82	-	-	100	89	97	0	0	0	0	0	0	log(Emax/EC50)	0.0	-	-	6.5	6.3	-	-	7.7	6.9	7.5	0.0	0.0	0.0	0.0	0.0	0.0
NPFF2	NPFF2		Neuropeptide FF/neuropeptide AF	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	2	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NPFF2	NPFF2		Neuropeptide FF/neuropeptide AF	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	-	-	-	-	-	Gz	0	-	-	84	82	-	-	100	89	97	0	0	0	0	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NPSR1	NPS		Neuropeptide S	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	1	-	1	-	Gq/11	2	2'	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NPSR1	NPS		Neuropeptide S	A	-	GproteinDb	merged data	-	-	-	-	-	1	-	1	-	Gq/11	2	2'	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NPBW1	NPBW1		Neuropeptide W/neuropeptide B	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NPBW1	NPBW1		Neuropeptide W/neuropeptide B	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NPBW2	NPBW2		Neuropeptide W/neuropeptide B	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NPBW2	NPBW2		Neuropeptide W/neuropeptide B	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NPY1R	Y₁		Neuropeptide Y	A	-	Bouvier	GEMTA	3	12		neuropeptide Y	Phys	-	3	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	log(Emax/EC50)	0.0	9.3	0.0	0.0	Gz	0	-	-	97	94	-	-	100	89	96	0	0	0	0	0	0	log(Emax/EC50)	0.0	-	-	9.0	8.7	-	-	9.3	8.2	8.9	0.0	0.0	0.0	0.0	0.0	0.0
NPY1R	Y₁		Neuropeptide Y	A	-	Martemyanov	FreeGβγ-Nluc	2	5		neuropeptide Y	Phys	-	3	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Activation rate (s^-1)	0.0	0.2	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.2	-	0.0	-	-	0.0	-	0.0
NPY1R	Y₁		Neuropeptide Y	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	3	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NPY1R	Y₁		Neuropeptide Y	A	-	GproteinDb	merged data	-	-	-	-	-	-	3	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	-	-	-	-	-	Gz	0	-	-	97	94	-	-	100	94	96	0	0	0	0	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NPY2R	Y₂		Neuropeptide Y	A	-	Martemyanov	FreeGβγ-Nluc	2	5		neuropeptide Y	Phys	-	2	1	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Activation rate (s^-1)	0.0	2.1	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	2.1	-	0.0	-	-	0.0	-	0.0
NPY2R	Y₂		Neuropeptide Y	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	2	1	-	Gi/o	2	-	1'	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NPY2R	Y₂		Neuropeptide Y	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	1	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	-	-	-	-	-	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NPY4R	Y₄		Neuropeptide Y	A	-	Martemyanov	FreeGβγ-Nluc	2	5		neuropeptide Y	Phys	-	2	1	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Activation rate (s^-1)	0.0	0.5	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.5	-	0.0	-	-	0.0	-	0.0
NPY4R	Y₄		Neuropeptide Y	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	2	1	-	Gi/o	2	-	1'	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NPY4R	Y₄		Neuropeptide Y	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	1	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	-	-	-	-	-	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NPY5R	Y₅		Neuropeptide Y	A	-	Bouvier	GEMTA	3	12		neuropeptide Y	Phys	-	3	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	log(Emax/EC50)	0.0	6.9	0.0	0.0	GoA	0	-	-	0	0	-	-	92	100	99	0	0	0	0	0	0	log(Emax/EC50)	0.0	-	-	0.0	0.0	-	-	6.4	6.9	6.9	0.0	0.0	0.0	0.0	0.0	0.0
NPY5R	Y₅		Neuropeptide Y	A	-	Martemyanov	FreeGβγ-Nluc	2	5		neuropeptide Y	Phys	-	3	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Activation rate (s^-1)	0.0	0.1	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.1	-	0.0	-	-	0.0	-	0.0
NPY5R	Y₅		Neuropeptide Y	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	3	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NPY5R	Y₅		Neuropeptide Y	A	-	GproteinDb	merged data	-	-	-	-	-	-	3	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	-	-	-	-	-	GoA	0	-	-	0	0	-	-	92	100	99	0	0	0	0	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NTR1	NTS₁		Neurotensin	A	-	Martemyanov	FreeGβγ-Nluc	2	5		neurotensin	Phys	1	3	4	2	Gq/11	3	nc	2'	1'	3'	0	35	100	29	Activation rate (s^-1)	0.0	1.4	4.2	1.2	Gq	0	-	-	-	-	-	-	-	35	-	100	-	-	22	-	29	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	1.4	-	4.2	-	-	0.9	-	1.2
NTR1	NTS₁		Neurotensin	A	-	Roth	TRUPATH	1	15		JMV431	Surr	1	3	4	2	Gq/11	3	nc	2'	1'	3'	0	97	100	97	log(Emax/EC50)	0.0	9.0	9.3	9.0	G11	0	0	0	95	96	92	97	97	97	95	95	100	-	98	94	97	log(Emax/EC50)	0.0	0.0	0.0	8.8	8.9	8.5	8.9	8.9	9.0	8.8	8.8	9.3	-	9.1	8.7	9.0
NTR1	NTS₁		Neurotensin	A	-	Inoue	TGF𝛼	5	1		neurotensin	Phys	1	3	4	2	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	9.3	-	-	-	-	-
NTR1	NTS₁		Neurotensin	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	1	3	4	2	Gq/11	3	2'	2'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NTR1	NTS₁		Neurotensin	A	-	GproteinDb	merged data	-	-	-	-	-	1	3	4	2	Gq/11	3	nc	2'	1'	3'	0	66	100	63	-	-	-	-	-	G11	0	0	0	95	96	92	97	97	66	95	98	100	-	60	94	63	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NTR2	NTS₂		Neurotensin	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	-	1	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NTR2	NTS₂		Neurotensin	A	-	GproteinDb	merged data	-	-	-	-	-	-	-	1	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
OPRD	δ		Opioid	A	-	Bouvier	GEMTA	3	12		SNC80	Surr	-	3	1	1	Gi/o	3	nc	1'	2'	3'	0	100	72	50	log(Emax/EC50)	0.0	9.3	6.7	4.7	Gz	0	-	-	96	92	-	-	100	95	99	0	0	57	72	0	50	log(Emax/EC50)	0.0	-	-	9.0	8.6	-	-	9.3	8.8	9.3	0.0	0.0	5.3	6.7	0.0	4.7
OPRD	δ		Opioid	A	-	Martemyanov	FreeGβγ-Nluc	2	5		[Leu]enkephalin	Phys	-	3	1	1	Gi/o	1	nc	1'	2'	nc	0	100	1	0	Activation rate (s^-1)	0.0	3.8	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	1	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	3.8	-	0.0	-	-	0.0	-	0.0
OPRD	δ		Opioid	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	3	1	1	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
OPRD	δ		Opioid	A	-	GproteinDb	merged data	-	-	-	-	-	-	3	1	1	Gi/o	3	nc	1'	2'	3'	0	100	36	25	-	-	-	-	-	Gz	0	-	-	96	92	-	-	100	98	99	0	0	57	36	0	25	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
OPRK	κ		Opioid	A	-	Bouvier	GEMTA	3	12		dynorphin A	Phys	-	3	1	2	Gi/o	3	nc	1'	3'	2'	0	100	74	78	log(Emax/EC50)	0.0	10.2	7.5	7.9	GoB	0	-	-	99	96	-	-	96	96	100	0	0	0	74	78	0	log(Emax/EC50)	0.0	-	-	10.0	9.7	-	-	9.8	9.7	10.2	0.0	0.0	0.0	7.5	7.9	0.0
OPRK	κ		Opioid	A	-	Martemyanov	FreeGβγ-Nluc	2	5		dynorphin A	Phys	-	3	1	2	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Activation rate (s^-1)	0.0	4.6	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	4.6	-	0.0	-	-	0.0	-	0.0
OPRK	κ		Opioid	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	3	1	2	Gi/o	2	-	1'	-	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
OPRK	κ		Opioid	A	-	GproteinDb	merged data	-	-	-	-	-	-	3	1	2	Gi/o	3	nc	1'	3'	2'	0	100	37	39	-	-	-	-	-	GoB	0	-	-	99	96	-	-	96	98	100	0	0	0	37	78	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
OPRM	μ		Opioid	A	-	Bouvier	GEMTA	3	12		DAMGO	Surr	-	5	2	-	Gi/o	2	nc	1'	2'	nc	0	100	64	0	log(Emax/EC50)	0.0	8.9	5.7	0.0	Gz	0	-	-	92	90	-	-	100	91	96	0	0	0	64	0	0	log(Emax/EC50)	0.0	-	-	8.2	8.1	-	-	8.9	8.1	8.6	0.0	0.0	0.0	5.7	0.0	0.0
OPRM	μ		Opioid	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	-	5	2	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Econstitutive	0.00	0.03	0.00	0.00	Gi1	0	-	-	100	-	-	-	-	-	-	0	-	-	-	0	-	Econstitutive	0.00	-	-	0.03	-	-	-	-	-	-	0.00	-	-	-	0.00	-
OPRM	μ		Opioid	A	-	Lambert	RGB-GDP	0	6		DAMGO	Surr	-	5	2	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Efficacy	0.00	0.05	0.00	0.00	Gi1	0	-	-	100	-	-	-	-	-	-	0	-	-	-	0	-	Efficacy	0.00	-	-	0.05	-	-	-	-	-	-	0.00	-	-	-	0.00	-
OPRM	μ		Opioid	A	-	Martemyanov	FreeGβγ-Nluc	2	5		endomorphin-1	Phys	-	5	2	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Activation rate (s^-1)	0.0	1.3	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	1.3	-	0.0	-	-	0.0	-	0.0
OPRM	μ		Opioid	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	5	2	-	Gi/o	2	-	1'	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
OPRM	μ		Opioid	A	-	GproteinDb	merged data	-	-	-	-	-	-	5	2	-	Gi/o	2	nc	1'	2'	nc	0	100	16	0	-	-	-	-	-	Gz	0	-	-	97	90	-	-	100	96	96	0	0	0	32	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
OPRX	NOP		Opioid	A	-	Bouvier	GEMTA	3	12		nociceptin/orphanin FQ	Phys	-	3	2	-	Gi/o	2	nc	1'	2'	nc	0	100	84	0	log(Emax/EC50)	0.0	10.8	9.1	0.0	Gz	0	-	-	93	89	-	-	100	91	96	0	0	69	84	0	0	log(Emax/EC50)	0.0	-	-	10.1	9.6	-	-	10.8	9.8	10.3	0.0	0.0	7.4	9.1	0.0	0.0
OPRX	NOP		Opioid	A	-	Martemyanov	FreeGβγ-Nluc	2	5		nociceptin/orphanin FQ	Phys	-	3	2	-	Gi/o	2	nc	1'	2'	nc	0	100	1	0	Activation rate (s^-1)	0.0	4.8	0.1	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	1	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	4.8	-	0.0	-	-	0.1	-	0.0
OPRX	NOP		Opioid	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	3	2	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
OPRX	NOP		Opioid	A	-	GproteinDb	merged data	-	-	-	-	-	-	3	2	-	Gi/o	2	nc	1'	2'	nc	0	100	42	0	-	-	-	-	-	Gz	0	-	-	93	89	-	-	100	96	96	0	0	69	42	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
OX1R	OX₁		Orexin	A	-	Martemyanov	FreeGβγ-Nluc	2	5		orexin-A	Phys	1	2	3	1	Gq/11	3	nc	2'	1'	3'	0	30	100	23	Activation rate (s^-1)	0.0	0.2	0.7	0.2	Gq	0	-	-	-	-	-	-	-	30	-	100	-	-	3	-	23	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.2	-	0.7	-	-	0.0	-	0.2
OX1R	OX₁		Orexin	A	-	Inoue	TGF𝛼	5	1		orexin-A	Phys	1	2	3	1	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	8.9	-	-	-	-	-
OX1R	OX₁		Orexin	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	1	2	3	1	Gq/11	3	1'	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
OX1R	OX₁		Orexin	A	-	GproteinDb	merged data	-	-	-	-	-	1	2	3	1	Gq/11	3	nc	2'	1'	3'	0	30	100	23	-	-	-	-	-	Gq	0	-	-	-	-	-	-	-	30	-	100	-	-	3	-	23	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
OX2R	OX₂		Orexin	A	-	Bouvier	GEMTA	3	12		orexin-A	Phys	1	3	4	2	Gq/11	3	nc	2'	1'	3'	0	92	100	73	log(Emax/EC50)	0.0	8.4	9.1	6.7	Gq	0	-	-	74	69	-	-	92	78	83	100	100	94	79	73	66	log(Emax/EC50)	0.0	-	-	6.7	6.3	-	-	8.4	7.1	7.6	9.1	9.1	8.6	7.2	6.7	6.0
OX2R	OX₂		Orexin	A	-	Martemyanov	FreeGβγ-Nluc	2	5		orexin-B	Phys	1	3	4	2	Gq/11	3	nc	2'	1'	3'	0	11	100	7	Activation rate (s^-1)	0.0	0.1	0.8	0.1	Gq	0	-	-	-	-	-	-	-	11	-	100	-	-	0	-	7	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.1	-	0.8	-	-	0.0	-	0.1
OX2R	OX₂		Orexin	A	-	Inoue	TGF𝛼	5	1		orexin-A	Phys	1	3	4	2	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	7.8	-	-	-	-	-
OX2R	OX₂		Orexin	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	1	3	4	2	Gi/o	3	1'	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
OX2R	OX₂		Orexin	A	-	GproteinDb	merged data	-	-	-	-	-	1	3	4	2	Gq/11	3	nc	2'	1'	3'	0	52	100	40	-	-	-	-	-	Gq	0	-	-	74	69	-	-	92	44	83	100	100	94	40	73	36	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
QRFPR	QRFP		Peptide P518	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	1	1	-	Gq/11	2	-	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
QRFPR	QRFP		Peptide P518	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	1	-	Gq/11	2	-	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PRLHR	PrRP		Prolactin-releasing peptide	A	-	Inoue	TGF𝛼	5	1		PrRP-20	Phys	-	-	1	-	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	7.8	-	-	-	-	-
PAR1	PAR1		Proteinase-activated	A	-	Bouvier	GEMTA	3	12		TFLLR-NH₂	Phys	-	1	2	1	G12/13	3	nc	3'	2'	1'	0	86	93	100	log(Emax/EC50)	0.0	5.6	6.1	6.5	G13	0	-	-	58	66	-	-	86	73	82	93	93	81	87	0	100	log(Emax/EC50)	0.0	-	-	3.8	4.3	-	-	5.6	4.8	5.4	6.1	6.1	5.3	5.7	0.0	6.5
PAR1	PAR1		Proteinase-activated	A	-	Inoue	TGF𝛼	5	1		TFLLR-NH₂	Phys	-	1	2	1	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	7.1	-	-	-	-	-
PAR1	PAR1		Proteinase-activated	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	2	1	G12/13	3	nc	3'	2'	1'	0	86	93	100	-	-	-	-	-	G13	0	-	-	58	66	-	-	86	73	82	93	93	81	87	0	100	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PAR2	PAR2		Proteinase-activated	A	-	Bouvier	GEMTA	3	12		PAR2 peptide	Phys	-	1	1	1	G12/13	3	nc	2'	3'	1'	0	89	86	100	log(Emax/EC50)	0.0	5.9	5.6	6.6	G12	0	-	-	78	79	-	-	84	80	89	71	86	77	84	100	97	log(Emax/EC50)	0.0	-	-	5.1	5.2	-	-	5.5	5.2	5.9	4.6	5.6	5.1	5.5	6.6	6.4
PAR2	PAR2		Proteinase-activated	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	1	1	G12/13	3	nc	2'	3'	1'	0	89	86	100	-	-	-	-	-	G12	0	-	-	78	79	-	-	84	80	89	71	86	77	84	100	97	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PAR3	PAR3		Proteinase-activated	A	-	Inoue	TGF𝛼	5	1		thrombin	Phys	-	-	1	-	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	7.2	-	-	-	-	-
PAR4	PAR4		Proteinase-activated	A	-	Inoue	TGF𝛼	5	1		thrombin	Phys	-	-	1	-	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	7.4	-	-	-	-	-
RXFP1	RXFP1		Relaxin family peptide	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	1	1	-	-	Gi/o	2	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
RXFP1	RXFP1		Relaxin family peptide	A	-	GproteinDb	merged data	-	-	-	-	-	1	1	-	-	Gi/o	2	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
RXFP2	RXFP2		Relaxin family peptide	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	1	1	-	-	Gi/o	2	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
RXFP2	RXFP2		Relaxin family peptide	A	-	GproteinDb	merged data	-	-	-	-	-	1	1	-	-	Gi/o	2	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
RL3R1	RXFP3		Relaxin family peptide	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
RL3R1	RXFP3		Relaxin family peptide	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
RL3R2	RXFP4		Relaxin family peptide	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
RL3R2	RXFP4		Relaxin family peptide	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SSR1	SST1		Somatostatin	A	-	Martemyanov	FreeGβγ-Nluc	2	5		SRIF-14	Phys	-	2	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Activation rate (s^-1)	0.0	0.2	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.2	-	0.0	-	-	0.0	-	0.0
SSR1	SST1		Somatostatin	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	2	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SSR1	SST1		Somatostatin	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	-	-	-	-	-	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SSR2	SST2		Somatostatin	A	-	Bouvier	GEMTA	3	12		SRIF-14	Phys	-	3	1	1	Gi/o	3	nc	1'	2'	3'	0	100	75	67	log(Emax/EC50)	0.0	10.7	8.0	7.1	Gz	0	-	-	96	93	-	-	100	90	96	62	0	70	75	67	0	log(Emax/EC50)	0.0	-	-	10.2	10.0	-	-	10.7	9.6	10.2	6.6	0.0	7.5	8.0	7.1	0.0
SSR2	SST2		Somatostatin	A	-	Martemyanov	FreeGβγ-Nluc	2	5		SRIF-14	Phys	-	3	1	1	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Activation rate (s^-1)	0.0	1.8	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	1.8	-	0.0	-	-	0.0	-	0.0
SSR2	SST2		Somatostatin	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	3	1	1	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SSR2	SST2		Somatostatin	A	-	GproteinDb	merged data	-	-	-	-	-	-	3	1	1	Gi/o	3	nc	1'	2'	3'	0	100	38	34	-	-	-	-	-	Gz	0	-	-	96	93	-	-	100	95	96	31	0	70	38	67	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SSR3	SST3		Somatostatin	A	-	Martemyanov	FreeGβγ-Nluc	2	5		SRIF-14	Phys	-	2	-	-	Gi/o	1	nc	1'	2'	nc	0	100	2	0	Activation rate (s^-1)	0.0	2.3	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	2	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	2.3	-	0.0	-	-	0.0	-	0.0
SSR3	SST3		Somatostatin	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	2	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SSR3	SST3		Somatostatin	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	-	-	Gi/o	2	nc	1'	2'	nc	0	100	2	0	-	-	-	-	-	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	2	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SSR4	SST4		Somatostatin	A	-	Martemyanov	FreeGβγ-Nluc	2	5		SRIF-14	Phys	-	2	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Activation rate (s^-1)	0.0	0.2	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.2	-	0.0	-	-	0.0	-	0.0
SSR4	SST4		Somatostatin	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	2	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SSR4	SST4		Somatostatin	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	-	-	-	-	-	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SSR5	SST5		Somatostatin	A	-	Martemyanov	FreeGβγ-Nluc	2	5		SRIF-14	Phys	-	2	1	-	Gi/o	1	nc	1'	2'	nc	0	100	1	0	Activation rate (s^-1)	0.0	4.4	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	1	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	4.4	-	0.0	-	-	0.0	-	0.0
SSR5	SST5		Somatostatin	A	-	Inoue	TGF𝛼	5	1		SRIF-14	Phys	-	2	1	-	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	7.3	-	-	-	-	-
SSR5	SST5		Somatostatin	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	2	1	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
SSR5	SST5		Somatostatin	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	1	-	Gi/o	2	nc	1'	2'	nc	0	100	1	0	-	-	-	-	-	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	1	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NK1R	NK₁		Tachykinin	A	-	Martemyanov	FreeGβγ-Nluc	2	5		substance P	Phys	1	1	3	1	Gq/11	3	nc	3'	1'	2'	0	6	100	48	Activation rate (s^-1)	0.0	0.3	4.2	2.0	Gq	0	-	-	-	-	-	-	-	6	-	100	-	-	4	-	48	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.3	-	4.2	-	-	0.2	-	2.0
NK1R	NK₁		Tachykinin	A	-	Inoue	TGF𝛼	5	1		substance P	Phys	1	1	3	1	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	9.5	-	-	-	-	-
NK1R	NK₁		Tachykinin	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	1	1	3	1	Gq/11	2	1'	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NK1R	NK₁		Tachykinin	A	-	GproteinDb	merged data	-	-	-	-	-	1	1	3	1	Gq/11	3	nc	3'	1'	2'	0	6	100	48	-	-	-	-	-	Gq	0	-	-	-	-	-	-	-	6	-	100	-	-	4	-	48	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NK2R	NK₂		Tachykinin	A	-	Martemyanov	FreeGβγ-Nluc	2	5		neurokinin A	Phys	1	1	3	1	Gq/11	3	nc	2'	1'	3'	0	29	100	7	Activation rate (s^-1)	0.0	1.4	4.6	0.3	Gq	0	-	-	-	-	-	-	-	29	-	100	-	-	10	-	7	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	1.4	-	4.6	-	-	0.5	-	0.3
NK2R	NK₂		Tachykinin	A	-	Inoue	TGF𝛼	5	1		neurokinin B	Phys	1	1	3	1	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	9.5	-	-	-	-	-
NK2R	NK₂		Tachykinin	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	1	1	3	1	Gq/11	2	1'	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NK2R	NK₂		Tachykinin	A	-	GproteinDb	merged data	-	-	-	-	-	1	1	3	1	Gq/11	3	nc	2'	1'	3'	0	29	100	7	-	-	-	-	-	Gq	0	-	-	-	-	-	-	-	29	-	100	-	-	10	-	7	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NK3R	NK₃		Tachykinin	A	-	Martemyanov	FreeGβγ-Nluc	2	5		neurokinin B	Phys	-	1	3	1	Gq/11	3	nc	3'	1'	2'	0	7	100	67	Activation rate (s^-1)	0.0	0.2	2.9	1.9	Gq	0	-	-	-	-	-	-	-	7	-	100	-	-	15	-	67	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.2	-	2.9	-	-	0.4	-	1.9
NK3R	NK₃		Tachykinin	A	-	Inoue	TGF𝛼	5	1		neurokinin A	Phys	-	1	3	1	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	8.2	-	-	-	-	-
NK3R	NK₃		Tachykinin	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	1	3	1	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
NK3R	NK₃		Tachykinin	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	3	1	Gq/11	3	nc	3'	1'	2'	0	7	100	67	-	-	-	-	-	Gq	0	-	-	-	-	-	-	-	7	-	100	-	-	15	-	67	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GPR3	GPR3		A orphans	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	1	-	-	-	Gs	1	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GPR3	GPR3		A orphans	A	-	GproteinDb	merged data	-	-	-	-	-	1	-	-	-	Gs	1	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TRFR	TRH₁		Thyrotropin-releasing hormone	A	-	Inoue	TGF𝛼	5	1		TRH	Phys	-	-	2	-	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	9.6	-	-	-	-	-
TRFR	TRH₁		Thyrotropin-releasing hormone	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	-	2	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TRFR	TRH₁		Thyrotropin-releasing hormone	A	-	GproteinDb	merged data	-	-	-	-	-	-	-	2	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
UR2R	UT		Urotensin	A	-	Inoue	TGF𝛼	5	1		urotensin-II	Phys	-	-	2	-	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	9.2	-	-	-	-	-
UR2R	UT		Urotensin	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	-	2	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
UR2R	UT		Urotensin	A	-	GproteinDb	merged data	-	-	-	-	-	-	-	2	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
V1AR	V_1A		Vasopressin and oxytocin	A	-	Bouvier	GEMTA	3	12		vasopressin	Phys	-	2	4	-	Gq/11	2	nc	2'	1'	nc	0	80	100	0	log(Emax/EC50)	0.0	7.0	8.7	0.0	G11	0	-	-	78	77	-	-	80	79	78	98	100	93	91	0	0	log(Emax/EC50)	0.0	-	-	6.8	6.7	-	-	7.0	6.9	6.8	8.5	8.7	8.1	7.9	0.0	0.0
V1AR	V_1A		Vasopressin and oxytocin	A	-	Martemyanov	FreeGβγ-Nluc	2	5		vasopressin	Phys	-	2	4	-	Gq/11	2	nc	2'	1'	nc	0	17	100	0	Activation rate (s^-1)	0.0	0.1	0.7	0.0	Gq	0	-	-	-	-	-	-	-	17	-	100	-	-	8	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.1	-	0.7	-	-	0.1	-	0.0
V1AR	V_1A		Vasopressin and oxytocin	A	-	Inoue	TGF𝛼	5	1		vasopressin	Phys	-	2	4	-	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	10.1	-	-	-	-	-
V1AR	V_1A		Vasopressin and oxytocin	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	2	4	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
V1AR	V_1A		Vasopressin and oxytocin	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	4	-	Gq/11	2	nc	2'	1'	nc	0	48	100	0	-	-	-	-	-	G11	0	-	-	78	77	-	-	80	48	78	99	100	93	50	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
V1BR	V_1B		Vasopressin and oxytocin	A	-	Martemyanov	FreeGβγ-Nluc	2	5		vasopressin	Phys	-	1	3	-	Gq/11	2	nc	2'	1'	nc	0	21	100	0	Activation rate (s^-1)	0.0	0.1	0.6	0.0	Gq	0	-	-	-	-	-	-	-	21	-	100	-	-	9	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.1	-	0.6	-	-	0.1	-	0.0
V1BR	V_1B		Vasopressin and oxytocin	A	-	Inoue	TGF𝛼	5	1		vasopressin	Phys	-	1	3	-	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	9.5	-	-	-	-	-
V1BR	V_1B		Vasopressin and oxytocin	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	1	3	-	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
V1BR	V_1B		Vasopressin and oxytocin	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	3	-	Gq/11	2	nc	2'	1'	nc	0	21	100	0	-	-	-	-	-	Gq	0	-	-	-	-	-	-	-	21	-	100	-	-	9	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
V2R	V₂		Vasopressin and oxytocin	A	-	Bouvier	GEMTA	3	12		vasopressin	Phys	4	3	4	2	Gs	4	1'	4'	2'	3'	100	60	88	77	log(Emax/EC50)	10.1	6.1	8.9	7.8	GsL	100	-	-	60	51	-	-	0	55	0	69	70	65	88	0	77	log(Emax/EC50)	10.1	-	-	6.1	5.1	-	-	0.0	5.5	0.0	6.9	7.1	6.5	8.9	0.0	7.8
V2R	V₂		Vasopressin and oxytocin	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	4	3	4	2	-	0	nc	nc	nc	nc	0	0	0	0	Econstitutive	0.00	0.00	0.00	0.00	-	0	-	-	0	-	-	-	-	-	-	0	-	-	-	0	-	Econstitutive	0.00	-	-	0.00	-	-	-	-	-	-	0.00	-	-	-	0.00	-
V2R	V₂		Vasopressin and oxytocin	A	-	Lambert	RGB-GDP	0	6		vasopressin	Phys	4	3	4	2	Gs	3	1'	2'	3'	nc	100	42	33	0	Efficacy	0.06	0.03	0.02	0.00	GsL	100	-	-	42	-	-	-	-	-	-	33	-	-	-	0	-	Efficacy	0.06	-	-	0.03	-	-	-	-	-	-	0.02	-	-	-	0.00	-
V2R	V₂		Vasopressin and oxytocin	A	-	Martemyanov	FreeGβγ-Nluc	2	5		vasopressin	Phys	4	3	4	2	Gs	4	1'	3'	2'	4'	100	6	41	5	Activation rate (s^-1)	1.4	0.1	0.6	0.1	GsL	100	-	-	-	-	-	-	-	6	-	11	-	-	41	-	5	Activation rate (s^-1)	1.4	-	-	-	-	-	-	-	0.1	-	0.2	-	-	0.6	-	0.1
V2R	V₂		Vasopressin and oxytocin	A	-	Inoue	TGF𝛼	5	1		vasopressin	Phys	4	3	4	2	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	8.5	-	-	-	-	-
V2R	V₂		Vasopressin and oxytocin	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	4	3	4	2	Gs	1	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
V2R	V₂		Vasopressin and oxytocin	A	-	GproteinDb	merged data	-	-	-	-	-	4	3	4	2	Gs	4	1'	3'	2'	4'	75	27	40	20	-	-	-	-	-	GsL	75	-	-	34	51	-	-	0	30	0	28	70	65	64	0	41	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
OXYR	OT		Vasopressin and oxytocin	A	-	Bouvier	GEMTA	3	12		oxytocin	Phys	-	3	5	-	Gq/11	1	nc	nc	1'	nc	0	0	100	0	log(Emax/EC50)	0.0	0.0	7.6	0.0	Gq	0	-	-	0	0	-	-	0	0	0	100	100	90	96	0	0	log(Emax/EC50)	0.0	-	-	0.0	0.0	-	-	0.0	0.0	0.0	7.6	7.6	6.8	7.3	0.0	0.0
OXYR	OT		Vasopressin and oxytocin	A	-	Lambert	RGB-GDP	0	6	-	None (constitutive activity)	-	-	3	5	-	-	0	nc	nc	nc	nc	0	0	0	0	Econstitutive	0.00	0.00	0.00	0.00	-	0	-	-	0	-	-	-	-	-	-	0	-	-	-	0	-	Econstitutive	0.00	-	-	0.00	-	-	-	-	-	-	0.00	-	-	-	0.00	-
OXYR	OT		Vasopressin and oxytocin	A	-	Lambert	RGB-GDP	0	6	-	oxytocin	Phys	-	3	5	-	Gq/11	2	nc	2'	1'	nc	0	69	100	0	Efficacy	0.00	0.03	0.04	0.00	Gq	0	-	-	69	-	-	-	-	-	-	100	-	-	-	0	-	Efficacy	0.00	-	-	0.03	-	-	-	-	-	-	0.04	-	-	-	0.00	-
OXYR	OT		Vasopressin and oxytocin	A	-	Martemyanov	FreeGβγ-Nluc	2	5		oxytocin	Phys	-	3	5	-	Gq/11	2	nc	2'	1'	nc	0	13	100	0	Activation rate (s^-1)	0.0	0.1	0.6	0.0	Gq	0	-	-	-	-	-	-	-	13	-	100	-	-	17	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.1	-	0.6	-	-	0.1	-	0.0
OXYR	OT		Vasopressin and oxytocin	A	-	Inoue	TGF𝛼	5	1		oxytocin	Phys	-	3	5	-	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	8.0	-	-	-	-	-
OXYR	OT		Vasopressin and oxytocin	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	3	5	-	Gq/11	2	-	2'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
OXYR	OT		Vasopressin and oxytocin	A	-	GproteinDb	merged data	-	-	-	-	-	-	3	5	-	Gq/11	2	nc	2'	1'	nc	0	20	75	0	-	-	-	-	-	G11	0	-	-	23	0	-	-	0	6	0	75	100	90	56	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CML1	Chemerin		Chemerin receptor	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CML1	Chemerin		Chemerin receptor	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CCR1	CCR1		Chemokine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CCR1	CCR1		Chemokine	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CCR2	CCR2		Chemokine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CCR2	CCR2		Chemokine	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CCR3	CCR3		Chemokine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CCR3	CCR3		Chemokine	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CCR4	CCR4		Chemokine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CCR4	CCR4		Chemokine	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CCR5	CCR5		Chemokine	A	-	Bouvier	GEMTA	3	12		CCL3	Phys	-	2	1	-	Gi/o	2	nc	1'	2'	nc	0	100	70	0	log(Emax/EC50)	0.0	9.1	6.4	0.0	Gz	0	-	-	98	96	-	-	100	94	97	0	0	0	70	0	0	log(Emax/EC50)	0.0	-	-	8.9	8.7	-	-	9.1	8.5	8.8	0.0	0.0	0.0	6.4	0.0	0.0
CCR5	CCR5		Chemokine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	2	1	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CCR5	CCR5		Chemokine	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	1	-	Gi/o	2	nc	1'	2'	nc	0	100	70	0	-	-	-	-	-	Gz	0	-	-	98	96	-	-	100	94	97	0	0	0	70	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CCR6	CCR6		Chemokine	A	-	Bouvier	GEMTA	3	12		CCL2	Phys	-	2	1	1	G12/13	3	nc	2'	3'	1'	0	95	95	100	log(Emax/EC50)	0.0	8.2	8.2	8.6	G12	0	-	-	86	94	-	-	95	83	91	0	0	0	95	100	0	log(Emax/EC50)	0.0	-	-	7.3	8.1	-	-	8.2	7.1	7.8	0.0	0.0	0.0	8.2	8.6	0.0
CCR6	CCR6		Chemokine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	2	1	1	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CCR6	CCR6		Chemokine	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	1	1	G12/13	3	nc	2'	3'	1'	0	95	95	100	-	-	-	-	-	G12	0	-	-	86	94	-	-	95	83	91	0	0	0	95	100	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CCR7	CCR7		Chemokine	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CCR7	CCR7		Chemokine	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CCR8	CCR8		Chemokine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CCR8	CCR8		Chemokine	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CCR9	CCR9		Chemokine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CCR9	CCR9		Chemokine	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CCR10	CCR10		Chemokine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CCR10	CCR10		Chemokine	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CXCR1	CXCR1		Chemokine	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	1	1	-	Gi/o	2	-	1'	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CXCR1	CXCR1		Chemokine	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	1	-	Gi/o	2	-	1'	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CXCR2	CXCR2		Chemokine	A	-	Bouvier	GEMTA	3	12		CXCL8	Phys	-	2	1	-	Gi/o	2	nc	1'	2'	nc	0	100	87	0	log(Emax/EC50)	0.0	9.4	8.2	0.0	GoB	0	-	-	99	99	-	-	91	97	100	0	0	0	87	0	0	log(Emax/EC50)	0.0	-	-	9.4	9.3	-	-	8.6	9.1	9.4	0.0	0.0	0.0	8.2	0.0	0.0
CXCR2	CXCR2		Chemokine	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	2	1	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CXCR2	CXCR2		Chemokine	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	1	-	Gi/o	2	nc	1'	2'	nc	0	100	87	0	-	-	-	-	-	GoB	0	-	-	99	99	-	-	91	97	100	0	0	0	87	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CXCR3	CXCR3		Chemokine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CXCR3	CXCR3		Chemokine	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CXCR4	CXCR4		Chemokine	A	-	Bouvier	GEMTA	3	12		CXCL12α	Phys	-	3	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	log(Emax/EC50)	0.0	8.5	0.0	0.0	Gi2	0	-	-	97	100	-	-	88	92	95	0	0	0	0	0	0	log(Emax/EC50)	0.0	-	-	8.3	8.5	-	-	7.5	7.8	8.1	0.0	0.0	0.0	0.0	0.0	0.0
CXCR4	CXCR4		Chemokine	A	-	Martemyanov	FreeGβγ-Nluc	2	5		CXCL12α	Phys	-	3	-	-	Gi/o	1	nc	1'	2'	nc	0	100	7	0	Activation rate (s^-1)	0.0	0.3	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	7	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.3	-	0.0	-	-	0.0	-	0.0
CXCR4	CXCR4		Chemokine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	3	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CXCR4	CXCR4		Chemokine	A	-	GproteinDb	merged data	-	-	-	-	-	-	3	-	-	Gi/o	2	nc	1'	2'	nc	0	100	4	0	-	-	-	-	-	Gi2	0	-	-	97	100	-	-	88	96	95	0	0	0	4	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CXCR5	CXCR5		Chemokine	A	-	Bouvier	GEMTA	3	12		CXCL13	Phys	-	2	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	log(Emax/EC50)	0.0	8.2	0.0	0.0	GoB	0	-	-	95	94	-	-	99	96	100	0	0	0	0	0	0	log(Emax/EC50)	0.0	-	-	7.7	7.6	-	-	8.1	7.8	8.2	0.0	0.0	0.0	0.0	0.0	0.0
CXCR5	CXCR5		Chemokine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	2	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CXCR5	CXCR5		Chemokine	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	-	-	-	-	-	GoB	0	-	-	95	94	-	-	99	96	100	0	0	0	0	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CXCR6	CXCR6		Chemokine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CXCR6	CXCR6		Chemokine	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CX3C1	CX₃CR1		Chemokine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CX3C1	CX₃CR1		Chemokine	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XCR1	XCR1		Chemokine	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
XCR1	XCR1		Chemokine	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
FSHR	FSH		Glycoprotein hormone	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	1	1	1	-	Gq/11	3	1'	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
FSHR	FSH		Glycoprotein hormone	A	-	GproteinDb	merged data	-	-	-	-	-	1	1	1	-	Gq/11	3	1'	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LSHR	LH		Glycoprotein hormone	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	1	-	1	-	Gs	2	1'	-	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LSHR	LH		Glycoprotein hormone	A	-	GproteinDb	merged data	-	-	-	-	-	1	-	1	-	Gs	2	1'	-	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TSHR	TSH		Glycoprotein hormone	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	1	-	1	-	Gs	2	1'	-	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
TSHR	TSH		Glycoprotein hormone	A	-	GproteinDb	merged data	-	-	-	-	-	1	-	1	-	Gs	2	1'	-	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKR1	PKR₁		Prokineticin	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	1	-	1	-	Gq/11	2	2'	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKR1	PKR₁		Prokineticin	A	-	GproteinDb	merged data	-	-	-	-	-	1	-	1	-	Gq/11	2	2'	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKR2	PKR₂		Prokineticin	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	1	1	1	-	Gq/11	3	2'	2'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PKR2	PKR₂		Prokineticin	A	-	GproteinDb	merged data	-	-	-	-	-	1	1	1	-	Gq/11	3	2'	2'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
FFAR1	FFA1		Free fatty acid	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	1	1	1	-	Gq/11	3	2'	2'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
FFAR1	FFA1		Free fatty acid	A	-	GproteinDb	merged data	-	-	-	-	-	1	1	1	-	Gq/11	3	2'	2'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
FFAR2	FFA2		Free fatty acid	A	-	Bouvier	GEMTA	3	12		propanoic acid	Phys	-	2	2	-	Gi/o	2	nc	1'	2'	nc	0	100	95	0	log(Emax/EC50)	0.0	4.3	4.1	0.0	Gi1	0	-	-	100	95	-	-	0	0	0	87	90	95	0	0	0	log(Emax/EC50)	0.0	-	-	4.3	4.1	-	-	0.0	0.0	0.0	3.7	3.9	4.1	0.0	0.0	0.0
FFAR2	FFA2		Free fatty acid	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	2	2	-	Gq/11	2	-	2'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
FFAR2	FFA2		Free fatty acid	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	2	-	Gi/o	2	nc	1'	2'	nc	0	100	95	0	-	-	-	-	-	Gi1	0	-	-	100	95	-	-	0	0	0	87	90	95	0	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
FFAR3	FFA3		Free fatty acid	A	-	Bouvier	GEMTA	3	12		propanoic acid	Phys	-	2	-	1	Gi/o	2	nc	1'	nc	2'	0	100	0	86	log(Emax/EC50)	0.0	5.0	0.0	4.3	GoB	0	-	-	98	99	-	-	89	97	100	0	0	0	0	86	78	log(Emax/EC50)	0.0	-	-	4.8	4.9	-	-	4.4	4.8	5.0	0.0	0.0	0.0	0.0	4.3	3.9
FFAR3	FFA3		Free fatty acid	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	2	-	1	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
FFAR3	FFA3		Free fatty acid	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	-	1	Gi/o	2	nc	1'	nc	2'	0	100	0	86	-	-	-	-	-	GoB	0	-	-	98	99	-	-	89	97	100	0	0	0	0	86	78	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
FFAR4	FFA4		Free fatty acid	A	-	Bouvier	GEMTA	3	12		α-linolenic acid	Phys	-	1	2	1	Gq/11	3	nc	2'	1'	3'	0	92	100	78	log(Emax/EC50)	0.0	4.8	5.2	4.0	G15	0	-	-	91	91	-	-	0	86	92	84	87	96	100	0	78	log(Emax/EC50)	0.0	-	-	4.7	4.7	-	-	0.0	4.4	4.8	4.4	4.5	4.9	5.2	0.0	4.0
FFAR4	FFA4		Free fatty acid	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	1	2	1	Gq/11	1	-	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
FFAR4	FFA4		Free fatty acid	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	2	1	Gq/11	3	nc	2'	1'	3'	0	92	100	78	-	-	-	-	-	G15	0	-	-	91	91	-	-	0	86	92	84	87	96	100	0	78	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LT4R1	BLT₁		Leukotriene	A	-	Bouvier	GEMTA	3	12		LTB₄	Phys	-	2	3	1	Gi/o	3	nc	1'	2'	3'	0	100	97	85	log(Emax/EC50)	0.0	10.1	9.7	8.6	GoB	0	-	-	99	99	-	-	91	95	100	59	53	65	97	85	85	log(Emax/EC50)	0.0	-	-	10.0	10.0	-	-	9.2	9.5	10.1	5.9	5.4	6.5	9.7	8.6	8.6
LT4R1	BLT₁		Leukotriene	A	-	Inoue	TGF𝛼	5	1		LTB₄	Phys	-	2	3	1	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	7.3	-	-	-	-	-
LT4R1	BLT₁		Leukotriene	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	2	3	1	Gq/11	2	-	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LT4R1	BLT₁		Leukotriene	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	3	1	Gi/o	3	nc	1'	2'	3'	0	100	97	85	-	-	-	-	-	GoB	0	-	-	99	99	-	-	91	95	100	59	53	65	97	85	85	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LT4R2	BLT₂		Leukotriene	A	-	Bouvier	GEMTA	3	12		LTB₄	Phys	-	2	1	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	log(Emax/EC50)	0.0	8.4	0.0	0.0	Gi1	0	-	-	100	98	-	-	76	92	97	0	0	0	0	0	0	log(Emax/EC50)	0.0	-	-	8.4	8.2	-	-	6.4	7.8	8.2	0.0	0.0	0.0	0.0	0.0	0.0
LT4R2	BLT₂		Leukotriene	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	2	1	-	Gi/o	2	-	1'	2'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LT4R2	BLT₂		Leukotriene	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	1	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	-	-	-	-	-	Gi1	0	-	-	100	98	-	-	76	92	97	0	0	0	0	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CLTR1	CysLT₁		Leukotriene	A	-	Bouvier	GEMTA	3	12		LTB₄	Phys	-	2	3	-	Gi/o	2	nc	1'	2'	nc	0	100	89	0	log(Emax/EC50)	0.0	8.3	7.3	0.0	Gz	0	-	-	98	98	-	-	100	92	98	85	84	80	89	0	0	log(Emax/EC50)	0.0	-	-	8.2	8.1	-	-	8.3	7.6	8.1	7.0	6.9	6.6	7.3	0.0	0.0
CLTR1	CysLT₁		Leukotriene	A	-	Inoue	TGF𝛼	5	1		LTD₄	Phys	-	2	3	-	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	9.0	-	-	-	-	-
CLTR1	CysLT₁		Leukotriene	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	2	3	-	Gq/11	2	-	2'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CLTR1	CysLT₁		Leukotriene	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	3	-	Gi/o	2	nc	1'	2'	nc	0	100	89	0	-	-	-	-	-	Gz	0	-	-	98	98	-	-	100	92	98	85	84	80	89	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CLTR2	CysLT₂		Leukotriene	A	-	Bouvier	GEMTA	3	12		LTB₄	Phys	-	2	3	1	Gq/11	3	nc	3'	1'	2'	0	90	100	94	log(Emax/EC50)	0.0	8.4	9.3	8.8	G15	0	-	-	74	71	-	-	90	73	80	91	90	94	100	94	87	log(Emax/EC50)	0.0	-	-	6.9	6.6	-	-	8.4	6.8	7.5	8.5	8.4	8.7	9.3	8.8	8.1
CLTR2	CysLT₂		Leukotriene	A	-	Inoue	TGF𝛼	5	1		LTD₄	Phys	-	2	3	1	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	8.2	-	-	-	-	-
CLTR2	CysLT₂		Leukotriene	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	2	3	1	Gq/11	2	-	2'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CLTR2	CysLT₂		Leukotriene	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	3	1	Gq/11	3	nc	3'	1'	2'	0	90	100	94	-	-	-	-	-	G15	0	-	-	74	71	-	-	90	73	80	91	90	94	100	94	87	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
OXER1	OXE		Leukotriene	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
OXER1	OXE		Leukotriene	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LPAR1	LPA₁		Lysophospholipid (LPA)	A	-	Bouvier	GEMTA	3	12		2-oleoyl-LPA	Phys	-	2	3	2	Gi/o	3	nc	1'	3'	2'	0	100	73	93	log(Emax/EC50)	0.0	8.3	6.1	7.8	Gi1	0	-	-	100	0	-	-	0	95	0	73	66	55	69	0	93	log(Emax/EC50)	0.0	-	-	8.3	0.0	-	-	0.0	7.9	0.0	6.1	5.5	4.6	5.8	0.0	7.8
LPAR1	LPA₁		Lysophospholipid (LPA)	A	-	Inoue	TGF𝛼	5	1		LPA	Phys	-	2	3	2	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	7.0	-	-	-	-	-
LPAR1	LPA₁		Lysophospholipid (LPA)	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	2	3	2	G12/13	3	-	1'	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LPAR1	LPA₁		Lysophospholipid (LPA)	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	3	2	Gi/o	3	nc	1'	3'	2'	0	100	73	93	-	-	-	-	-	Gi1	0	-	-	100	0	-	-	0	95	0	73	66	55	69	0	93	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LPAR2	LPA₂		Lysophospholipid (LPA)	A	-	Bouvier	GEMTA	3	12		2-oleoyl-LPA	Phys	-	2	3	2	Gi/o	3	nc	1'	3'	2'	0	100	81	97	log(Emax/EC50)	0.0	8.5	6.9	8.2	GoB	0	-	-	94	95	-	-	85	91	100	80	78	81	73	0	97	log(Emax/EC50)	0.0	-	-	8.0	8.0	-	-	7.2	7.7	8.5	6.7	6.6	6.9	6.1	0.0	8.2
LPAR2	LPA₂		Lysophospholipid (LPA)	A	-	Inoue	TGF𝛼	5	1		LPA	Phys	-	2	3	2	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	7.6	-	-	-	-	-
LPAR2	LPA₂		Lysophospholipid (LPA)	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	2	3	2	Gi/o	3	-	1'	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LPAR2	LPA₂		Lysophospholipid (LPA)	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	3	2	Gi/o	3	nc	1'	3'	2'	0	100	81	97	-	-	-	-	-	GoB	0	-	-	94	95	-	-	85	91	100	80	78	81	73	0	97	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LPAR3	LPA₃		Lysophospholipid (LPA)	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	1	1	-	Gi/o	2	-	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LPAR3	LPA₃		Lysophospholipid (LPA)	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	1	-	Gi/o	2	-	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LPAR4	LPA₄		Lysophospholipid (LPA)	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	1	1	1	1	G12/13	4	1'	1'	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LPAR4	LPA₄		Lysophospholipid (LPA)	A	-	GproteinDb	merged data	-	-	-	-	-	1	1	1	1	G12/13	4	1'	1'	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LPAR5	LPA₅		Lysophospholipid (LPA)	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	-	1	1	Gq/11	2	-	-	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LPAR5	LPA₅		Lysophospholipid (LPA)	A	-	GproteinDb	merged data	-	-	-	-	-	-	-	1	1	Gq/11	2	-	-	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LPAR6	LPA₆		Lysophospholipid (LPA)	A	-	Roth	TRUPATH	1	15		LPA	Phys	2	2	-	2	Gs	3	1'	3'	nc	2'	100	9	0	10	log(Emax/EC50)	75.4	7.1	0.0	7.4	G13	0	75	0	78	85	72	87	89	95	96	0	0	-	0	98	100	log(Emax/EC50)	0.0	5.6	0.0	5.7	6.2	5.3	6.4	6.6	7.0	7.1	0.0	0.0	-	0.0	7.2	7.4
LPAR6	LPA₆		Lysophospholipid (LPA)	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	2	2	-	2	Gs	3	1'	1'	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
LPAR6	LPA₆		Lysophospholipid (LPA)	A	-	GproteinDb	merged data	-	-	-	-	-	2	2	-	2	Gs	3	1'	3'	nc	2'	100	9	0	10	-	-	-	-	-	G13	0	75	0	78	85	72	87	89	95	96	0	0	-	0	98	100	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
S1PR1	S1P₁		Lysophospholipid (S1P)	A	-	Bouvier	GEMTA	3	12		sphingosine 1-phosphate	Phys	-	2	1	1	Gi/o	3	nc	1'	3'	2'	0	100	79	86	log(Emax/EC50)	0.0	7.3	5.8	6.3	Gi1	0	-	-	100	96	-	-	0	91	95	0	0	0	79	86	86	log(Emax/EC50)	0.0	-	-	7.3	7.0	-	-	0.0	6.6	7.0	0.0	0.0	0.0	5.8	6.3	6.3
S1PR1	S1P₁		Lysophospholipid (S1P)	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	2	1	1	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
S1PR1	S1P₁		Lysophospholipid (S1P)	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	1	1	Gi/o	3	nc	1'	3'	2'	0	100	79	86	-	-	-	-	-	Gi1	0	-	-	100	96	-	-	0	91	95	0	0	0	79	86	86	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
S1PR2	S1P₂		Lysophospholipid (S1P)	A	-	Inoue	TGF𝛼	5	1		sphingosine 1-phosphate	Phys	1	-	2	1	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	7.2	-	-	-	-	-
S1PR2	S1P₂		Lysophospholipid (S1P)	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	1	-	2	1	Gs	3	1'	-	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
S1PR2	S1P₂		Lysophospholipid (S1P)	A	-	GproteinDb	merged data	-	-	-	-	-	1	-	2	1	Gs	3	1'	-	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
S1PR3	S1P₃		Lysophospholipid (S1P)	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	1	1	1	Gi/o	3	-	1'	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
S1PR3	S1P₃		Lysophospholipid (S1P)	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	1	1	Gi/o	3	-	1'	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
S1PR4	S1P₄		Lysophospholipid (S1P)	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	-	1	-	1	Gi/o	2	-	1'	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
S1PR4	S1P₄		Lysophospholipid (S1P)	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	-	1	Gi/o	2	-	1'	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
S1PR5	S1P₅		Lysophospholipid (S1P)	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	1	-	1	Gi/o	2	-	1'	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
S1PR5	S1P₅		Lysophospholipid (S1P)	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	-	1	Gi/o	2	-	1'	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CNR1	CB₁		Cannabinoid	A	-	Bouvier	GEMTA	3	12		WIN55212-2	Surr	3	5	2	3	Gq/11	3	nc	2'	1'	3'	0	100	100	91	log(Emax/EC50)	0.0	7.6	7.6	6.9	Gi1	0	-	-	100	93	-	-	92	97	99	0	0	48	100	91	88	log(Emax/EC50)	0.0	-	-	7.6	7.1	-	-	7.0	7.4	7.5	0.0	0.0	3.6	7.6	6.9	6.7
CNR1	CB₁		Cannabinoid	A	-	Lambert	RGB-GDP	0	6	-	None (constitutive activity)	-	3	5	2	3	Gi/o	3	3'	1'	nc	2'	34	100	0	41	Econstitutive	0.02	0.06	0.00	0.02	Gi1	34	-	-	100	-	-	-	-	-	-	0	-	-	-	41	-	Econstitutive	0.02	-	-	0.06	-	-	-	-	-	-	0.00	-	-	-	0.02	-
CNR1	CB₁		Cannabinoid	A	-	Lambert	RGB-GDP	0	6	-	CP55940	Surr	3	5	2	3	Gi/o	4	3'	1'	4'	2'	37	100	18	43	Efficacy	0.02	0.06	0.01	0.02	Gi1	37	-	-	100	-	-	-	-	-	-	18	-	-	-	43	-	Efficacy	0.02	-	-	0.06	-	-	-	-	-	-	0.01	-	-	-	0.02	-
CNR1	CB₁		Cannabinoid	A	-	Martemyanov	FreeGβγ-Nluc	2	5		anandamide	Phys	3	5	2	3	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Activation rate (s^-1)	0.0	0.1	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.1	-	0.0	-	-	0.0	-	0.0
CNR1	CB₁		Cannabinoid	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	3	5	2	3	Gi/o	2	2'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CNR1	CB₁		Cannabinoid	A	-	GproteinDb	merged data	-	-	-	-	-	3	5	2	3	Gi/o	4	4'	1'	3'	2'	18	100	30	44	-	-	-	-	-	Gi1	18	-	-	100	93	-	-	92	98	99	4	0	48	50	58	44	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CNR2	CB₂		Cannabinoid	A	-	Bouvier	GEMTA	3	12		WIN55212-2	Surr	1	2	1	-	Gi/o	2	nc	1'	2'	nc	0	100	60	0	log(Emax/EC50)	0.0	8.9	5.4	0.0	Gi1	0	-	-	100	98	-	-	93	91	97	0	0	0	60	0	0	log(Emax/EC50)	0.0	-	-	8.9	8.7	-	-	8.3	8.1	8.7	0.0	0.0	0.0	5.4	0.0	0.0
CNR2	CB₂		Cannabinoid	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	1	2	1	-	Gi/o	2	2'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
CNR2	CB₂		Cannabinoid	A	-	GproteinDb	merged data	-	-	-	-	-	1	2	1	-	Gi/o	2	nc	1'	2'	nc	0	100	60	0	-	-	-	-	-	Gi1	0	-	-	100	98	-	-	93	91	97	0	0	0	60	0	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GPR18	GPR18		GPR18, GPR55 and GPR119	A	-	Lambert	RGB-GDP	0	6		None (constitutive activity)	-	-	1	1	-	-	0	nc	nc	nc	nc	0	0	0	0	Econstitutive	0.00	0.00	0.00	0.00	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	-	0	Econstitutive	0.00	-	-	0.00	-	-	-	-	-	-	0.00	-	-	0.00	-	0.00
GPR18	GPR18		GPR18, GPR55 and GPR119	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	1	1	-	Gi/o	2	-	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GPR18	GPR18		GPR18, GPR55 and GPR119	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	1	-	-	0	nc	nc	nc	nc	0	0	0	0	-	-	-	-	-	-	0	-	-	0	-	-	-	-	-	-	0	-	-	0	-	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GPR55	GPR55		GPR18, GPR55 and GPR119	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	-	1	1	Gq/11	2	-	-	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GPR55	GPR55		GPR18, GPR55 and GPR119	A	-	GproteinDb	merged data	-	-	-	-	-	-	-	1	1	Gq/11	2	-	-	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GP119	GPR119		GPR18, GPR55 and GPR119	A	-	Inoue	TGF𝛼	5	1		GSK-1292263	Surr	1	-	1	-	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	7.3	-	-	-	-	-
GP119	GPR119		GPR18, GPR55 and GPR119	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	1	-	1	-	Gs	1	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
GP119	GPR119		GPR18, GPR55 and GPR119	A	-	GproteinDb	merged data	-	-	-	-	-	1	-	1	-	Gs	1	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PTAFR	PAF		Platelet-activating factor	A	-	Inoue	TGF𝛼	5	1		PAF	Phys	-	1	2	-	-	1	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	log(Emax/EC50)	-	-	-	-	-	-	-	-	-	-	8.7	-	-	-	-	-
PTAFR	PAF		Platelet-activating factor	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	1	2	-	Gi/o	2	-	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PTAFR	PAF		Platelet-activating factor	A	-	GproteinDb	merged data	-	-	-	-	-	-	1	2	-	Gi/o	2	-	1'	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PD2R	DP₁		Prostanoid	A	-	Inoue	NanoBiT-G	1	8		PGD₂	Phys	3	1	2	1	Gi/o	4	2'	1'	3'	4'	96	100	92	90	log(Emax/EC50)	7.1	7.4	6.8	6.7	Gi1	-	96	-	100	0	0	-	-	79	-	92	-	-	-	90	0	log(Emax/EC50)	-	7.1	-	7.4	0.0	0.0	-	-	5.9	-	6.8	-	-	-	6.7	0.0
PD2R	DP₁		Prostanoid	A	-	Martemyanov	FreeGβγ-Nluc	2	5		PGD₂	Phys	3	1	2	1	Gs	2	1'	nc	2'	nc	100	0	22	0	Activation rate (s^-1)	0.9	0.0	0.2	0.0	GsL	100	-	-	-	-	-	-	-	0	-	0	-	-	22	-	0	Activation rate (s^-1)	0.9	-	-	-	-	-	-	-	0.0	-	0.0	-	-	0.2	-	0.0
PD2R	DP₁		Prostanoid	A	-	GtoPdb	- (annotated from literature)	-	-	-	-	-	3	1	2	1	Gs	1	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PD2R	DP₁		Prostanoid	A	-	GproteinDb	merged data	-	-	-	-	-	3	1	2	1	Gs	4	1'	3'	2'	4'	98	50	57	45	-	-	-	-	-	Gi1	100	96	-	100	0	0	-	-	40	-	46	-	-	22	90	0	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PD2R2	DP₂		Prostanoid	A	-	Martemyanov	FreeGβγ-Nluc	2	5		PGD₂	Phys	-	2	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	Activation rate (s^-1)	0.0	0.6	0.0	0.0	GoA	0	-	-	-	-	-	-	-	100	-	0	-	-	0	-	0	Activation rate (s^-1)	0.0	-	-	-	-	-	-	-	0.6	-	0.0	-	-	0.0	-	0.0
PD2R2	DP₂		Prostanoid	A	-	GtoPdb	- (annotated from literature)	-	-		-	-	-	2	-	-	Gi/o	1	-	1'	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
PD2R2	DP₂		Prostanoid	A	-	GproteinDb	merged data	-	-	-	-	-	-	2	-	-	Gi/o	1	nc	1'	nc	nc	0	100	0	0	-	-	-	-	-	GoA	0	-	-	-	-	-	-	-

Join us

Cite us

Main reference