G Protein Couplings




Source Receptor Ligand Guide to Pharmacology Log(Emax/EC50) pEC50 Emax Standard Deviation
Group Biosensor Cl Receptor fam.
Uniprot
IUPHAR Ligand name Phys. / Surr. Gs Gi/o Gq/11 G12/13 Gs Gi/o Gq/11 G12/13 Gs Gi/o Gq/11 G12/13 Gs Gi/o Gq/11 G12/13 Gs Gi/o Gq/11 G12/13
































GPCRdb Mean A 5-Hydroxytryptamine 5HT1A 5-HT1A - - 1' - - 5.2 7.0 6.0 5.2 5.9 7.3 6.4 5.8 22 54 43 26 2.1 16.0 15.8 3.8 1
Bouvier GEMTA A 5-Hydroxytryptamine 5HT1A 5-HT1A 5-hydroxytryptamine Physiological - 1' - - - 8.0 6.1 - - 8.2 6.5 - - 61 46 - - 26.8 26.8 - Bouvier
Inoue TGF A 5-Hydroxytryptamine 5HT1A 5-HT1A 5-hydroxytryptamine Physiological - 1' - - 5.2 6.1 5.9 5.2 5.9 6.5 6.3 5.8 22 46 40 26 2.1 5.2 4.8 3.8 Inoue
GPCRdb Mean A 5-Hydroxytryptamine 5HT1A 5-HT1A - - 1' - - - 7.0 6.0 - - 7.3 6.4 - - 54 43 - - 16.0 15.8 - 2
GPCRdb Mean A 5-Hydroxytryptamine 5HT1A 5-HT1A - - 1' - - - 7.0 - - - 7.3 - - - 54 - - - 16.0 - - 3
GPCRdb Mean A 5-Hydroxytryptamine 5HT1A 5-HT1A - - 1' - - - 1' - - - 1' - - - 1' - - - 1' - - 4
GPCRdb Mean A 5-Hydroxytryptamine 5HT1B 5-HT1B - - 1' - - - 7.8 6.3 6.1 - 8.4 7.2 7.1 - 26 15 11 - 7.3 6.4 19.3 1
Bouvier GEMTA A 5-Hydroxytryptamine 5HT1B 5-HT1B 5-hydroxytryptamine Physiological - 1' - - - 8.7 6.2 - - 9.4 7.2 - - 26 12 - - 8.2 9.1 - Bouvier
Inoue TGF A 5-Hydroxytryptamine 5HT1B 5-HT1B 5-hydroxytryptamine Physiological - 1' - - - 6.9 6.4 6.1 - 7.5 7.2 7.1 - 27 18 11 - 6.5 3.7 19.3 Inoue
GPCRdb Mean A 5-Hydroxytryptamine 5HT1B 5-HT1B - - 1' - - - 7.8 6.3 - - 8.4 7.2 - - 26 15 - - 7.3 6.4 - 2
GPCRdb Mean A 5-Hydroxytryptamine 5HT1B 5-HT1B - - 1' - - - 7.8 - - - 8.4 - - - 26 - - - 7.3 - - 3
GPCRdb Mean A 5-Hydroxytryptamine 5HT1B 5-HT1B - - 1' - - - 1' - - - 1' - - - 1' - - - 1' - - 4
GPCRdb Mean A 5-Hydroxytryptamine 5HT1D 5-HT1D - - 1' - - - 7.9 7.1 6.8 - 8.6 8.0 7.8 - 26 20 10 - 4.2 1.5 1.0 1
Bouvier GEMTA A 5-Hydroxytryptamine 5HT1D 5-HT1D 5-hydroxytryptamine Physiological - 1' - - - 7.7 - - - 8.4 - - - 21 - - - 5.4 - - Bouvier
Inoue TGF A 5-Hydroxytryptamine 5HT1D 5-HT1D 5-hydroxytryptamine Physiological - 1' - - - 8.2 7.1 6.8 - 8.8 8.0 7.8 - 31 20 10 - 2.9 1.5 1.0 Inoue
GPCRdb Mean A 5-Hydroxytryptamine 5HT1D 5-HT1D - - 1' - - - 7.9 - - - 8.6 - - - 26 - - - 4.2 - - 2
GPCRdb Mean A 5-Hydroxytryptamine 5HT1D 5-HT1D - - 1' - - - 7.9 - - - 8.6 - - - 26 - - - 4.2 - - 3
GPCRdb Mean A 5-Hydroxytryptamine 5HT1D 5-HT1D - - 1' - - - 1' - - - 1' - - - 1' - - - 1' - - 4
GPCRdb Mean A 5-Hydroxytryptamine 5HT1E 5-ht1E - - 1' - - - 6.7 - - - 7.5 - - - 20 - - - 8.0 - - 1
Inoue TGF A 5-Hydroxytryptamine 5HT1E 5-ht1E 5-hydroxytryptamine Physiological - 1' - - - 6.7 - - - 7.5 - - - 20 - - - 8.0 - - Inoue
GPCRdb Mean A 5-Hydroxytryptamine 5HT1E 5-ht1E - - 1' - - - 6.7 - - - 7.5 - - - 20 - - - 8.0 - - 2
GPCRdb Mean A 5-Hydroxytryptamine 5HT1E 5-ht1E - - 1' - - - 1' - - - 1' - - - 1' - - - 1' - - 3
GPCRdb Mean A 5-Hydroxytryptamine 5HT1E 5-ht1E - - 1' - - - 1' - - - 1' - - - 1' - - - 1' - - 4
GPCRdb Mean A 5-Hydroxytryptamine 5HT1F 5-HT1F - - 1' - - - 6.5 - - - 7.3 - - - 16 - - - 1.7 - - 1
Inoue TGF A 5-Hydroxytryptamine 5HT1F 5-HT1F 5-hydroxytryptamine Physiological - 1' - - - 6.5 - - - 7.3 - - - 16 - - - 1.7 - - Inoue
GPCRdb Mean A 5-Hydroxytryptamine 5HT1F 5-HT1F - - 1' - - - 6.5 - - - 7.3 - - - 16 - - - 1.7 - - 2
GPCRdb Mean A 5-Hydroxytryptamine 5HT1F 5-HT1F - - 1' - - - 1' - - - 1' - - - 1' - - - 1' - - 3
GPCRdb Mean A 5-Hydroxytryptamine 5HT1F 5-HT1F - - 1' - - - 1' - - - 1' - - - 1' - - - 1' - - 4
GPCRdb Mean A 5-Hydroxytryptamine 5HT2A 5-HT2A - - 2' 1' - 5.5 6.5 8.0 6.0 6.2 7.2 8.5 6.3 24 26 30 38 13.9 4.2 19.9 8.3 1
Bouvier GEMTA A 5-Hydroxytryptamine 5HT2A 5-HT2A 5-hydroxytryptamine Physiological - 2' 1' - - 6.1 8.5 - - 7.0 9.0 - - 16 34 - - 2.5 32.6 - Bouvier
Inoue TGF A 5-Hydroxytryptamine 5HT2A 5-HT2A 5-hydroxytryptamine Physiological - 2' 1' - 5.5 7.0 7.4 6.0 6.2 7.5 8.0 6.3 24 37 27 38 13.9 5.9 7.2 8.3 Inoue
GPCRdb Mean A 5-Hydroxytryptamine 5HT2A 5-HT2A - - 2' 1' - - 6.5 8.0 - - 7.2 8.5 - - 26 30 - - 4.2 19.9 - 2
GPCRdb Mean A 5-Hydroxytryptamine 5HT2A 5-HT2A - - 2' 1' - - 6.5 8.0 - - 7.2 8.5 - - 26 30 - - 4.2 19.9 - 3
GPCRdb Mean A 5-Hydroxytryptamine 5HT2A 5-HT2A - - 2' 1' - - 2' 1' - - 2' 1' - - 2' 1' - - 2' 1' - 4
GPCRdb Mean A 5-Hydroxytryptamine 5HT2B 5-HT2B - - - 1' - 6.2 7.3 7.5 6.2 7.3 8.1 8.3 7.4 8 22 21 6 5.3 10.0 9.8 2.3 1
Bouvier GEMTA A 5-Hydroxytryptamine 5HT2B 5-HT2B 5-hydroxytryptamine Physiological - - 1' - - 7.5 7.6 - - 8.3 8.3 - - 18 22 - - 6.7 9.3 - Bouvier
Inoue TGF A 5-Hydroxytryptamine 5HT2B 5-HT2B 5-hydroxytryptamine Physiological - - 1' - 6.2 7.2 7.5 6.2 7.3 7.8 8.3 7.4 8 27 20 6 5.3 13.3 10.2 2.3 Inoue
GPCRdb Mean A 5-Hydroxytryptamine 5HT2B 5-HT2B - - - 1' - - 7.3 7.5 - - 8.1 8.3 - - 22 21 - - 10.0 9.8 - 2
GPCRdb Mean A 5-Hydroxytryptamine 5HT2B 5-HT2B - - - 1' - - - 7.5 - - - 8.3 - - - 21 - - - 9.8 - 3
GPCRdb Mean A 5-Hydroxytryptamine 5HT2B 5-HT2B - - - 1' - - - 1' - - - 1' - - - 1' - - - 1' - 4
GPCRdb Mean A 5-Hydroxytryptamine 5HT2C 5-HT2C - - 2' 1' - 6.3 7.7 8.1 7.6 6.8 8.2 8.6 7.8 31 40 40 50 14.2 20.4 27.2 17.5 1
Bouvier GEMTA A 5-Hydroxytryptamine 5HT2C 5-HT2C 5-hydroxytryptamine Physiological - 2' 1' - - 7.5 8.4 7.7 - 7.7 8.6 7.8 - 62 62 64 - 36.4 50.0 21.4 Bouvier
Inoue TGF A 5-Hydroxytryptamine 5HT2C 5-HT2C 5-hydroxytryptamine Physiological - 2' 1' - 6.3 7.9 7.8 7.4 6.8 8.7 8.6 7.8 31 17 17 36 14.2 4.5 4.4 13.6 Inoue
GPCRdb Mean A 5-Hydroxytryptamine 5HT2C 5-HT2C - - 2' 1' - - 7.7 8.1 7.6 - 8.2 8.6 7.8 - 40 40 50 - 20.4 27.2 17.5 2
GPCRdb Mean A 5-Hydroxytryptamine 5HT2C 5-HT2C - - 2' 1' - - 7.7 8.1 - - 8.2 8.6 - - 40 40 - - 20.4 27.2 - 3
GPCRdb Mean A 5-Hydroxytryptamine 5HT2C 5-HT2C - - 2' 1' - - 2' 1' - - 2' 1' - - 2' 1' - - 2' 1' - 4
GPCRdb Mean A 5-Hydroxytryptamine 5HT4R 5-HT4 - 1' - - 2' 6.5 7.2 6.7 6.2 7.0 7.5 7.1 6.7 44 41 38 35 10.7 10.3 11.6 13.9 1
Inoue TGF A 5-Hydroxytryptamine 5HT4R 5-HT4 5-hydroxytryptamine Physiological 1' - - 2' 6.5 7.2 6.7 6.2 7.0 7.5 7.1 6.7 44 41 38 35 10.7 10.3 11.6 13.9 Inoue
GPCRdb Mean A 5-Hydroxytryptamine 5HT4R 5-HT4 - 1' - - 2' 6.5 - - 6.2 7.0 - - 6.7 44 - - 35 10.7 - - 13.9 2
GPCRdb Mean A 5-Hydroxytryptamine 5HT4R 5-HT4 - 1' - - 2' 1' - - 2' 1' - - 2' 1' - - 2' 1' - - 2' 3
GPCRdb Mean A 5-Hydroxytryptamine 5HT4R 5-HT4 - 1' - - 2' 1' - - 2' 1' - - 2' 1' - - 2' 1' - - 2' 4
GPCRdb Mean A 5-Hydroxytryptamine 5HT5A 5-HT5A - - 1' 2' - - - - - - - - - - - - - - - - - 1
GPCRdb Mean A 5-Hydroxytryptamine 5HT5A 5-HT5A - - 1' 2' - - 1' 2' - - 1' 2' - - 1' 2' - - 1' 2' - 2
GPCRdb Mean A 5-Hydroxytryptamine 5HT5A 5-HT5A - - 1' 2' - - 1' 2' - - 1' 2' - - 1' 2' - - 1' 2' - 3
GPCRdb Mean A 5-Hydroxytryptamine 5HT5A 5-HT5A - - 1' 2' - - 1' 2' - - 1' 2' - - 1' 2' - - 1' 2' - 4
GPCRdb Mean A 5-Hydroxytryptamine 5HT6R 5-HT6 - 1' - 2' - 6.4 6.2 5.8 5.5 6.8 6.6 6.7 6.2 43 40 17 23 7.9 4.3 1.0 2.5 1
Inoue TGF A 5-Hydroxytryptamine 5HT6R 5-HT6 5-hydroxytryptamine Physiological 1' - 2' - 6.4 6.2 5.8 5.5 6.8 6.6 6.7 6.2 43 40 17 23 7.9 4.3 1.0 2.5 Inoue
GPCRdb Mean A 5-Hydroxytryptamine 5HT6R 5-HT6 - 1' - 2' - 6.4 - 5.8 - 6.8 - 6.7 - 43 - 17 - 7.9 - 1.0 - 2
GPCRdb Mean A 5-Hydroxytryptamine 5HT6R 5-HT6 - 1' - 2' - 1' - 2' - 1' - 2' - 1' - 2' - 1' - 2' - 3
GPCRdb Mean A 5-Hydroxytryptamine 5HT6R 5-HT6 - 1' - 2' - 1' - 2' - 1' - 2' - 1' - 2' - 1' - 2' - 4
GPCRdb Mean A 5-Hydroxytryptamine 5HT7R 5-HT7 - 1' - - - 8.1 8.2 8.2 8.2 8.5 8.9 8.8 8.9 40 18 24 18 9.2 4.4 3.9 4.3 1
Inoue TGF A 5-Hydroxytryptamine 5HT7R 5-HT7 5-hydroxytryptamine Physiological 1' - - - 8.3 8.2 8.2 8.2 8.8 8.9 8.8 8.9 34 18 24 18 9.2 4.4 3.9 4.3 Inoue
Roth TGF A 5-Hydroxytryptamine 5HT7R 5-HT7 5-hydroxytryptamine Physiological 1' - - - 7.8 - - - 8.2 - - - 47 - - - - - - - Roth
GPCRdb Mean A 5-Hydroxytryptamine 5HT7R 5-HT7 - 1' - - - 8.1 - - - 8.5 - - - 40 - - - 9.2 - - - 2
GPCRdb Mean A 5-Hydroxytryptamine 5HT7R 5-HT7 - 1' - - - 8.1 - - - 8.5 - - - 40 - - - 1' - - - 3
GPCRdb Mean A 5-Hydroxytryptamine 5HT7R 5-HT7 - 1' - - - 1' - - - 1' - - - 1' - - - 1' - - - 4
GPCRdb Mean A Acetylcholine (muscarinic) ACM1 M1 - - - 1' - 6.2 6.0 7.6 5.5 6.3 6.3 7.7 5.7 73 63 80 76 5.9 7.9 38.8 4.3 1
Bouvier GEMTA A Acetylcholine (muscarinic) ACM1 M1 acetylcholine Physiological - - 1' - 5.8 5.0 7.7 - 6.1 5.5 7.8 - 52 38 78 - 5.1 11.1 73.5 - Bouvier
Inoue TGF A Acetylcholine (muscarinic) ACM1 M1 acetylcholine Physiological - - 1' - 6.5 7.0 7.4 5.5 6.5 7.1 7.5 5.7 94 88 82 76 6.8 4.8 4.0 4.3 Inoue
GPCRdb Mean A Acetylcholine (muscarinic) ACM1 M1 - - - 1' - 6.2 6.0 7.6 - 6.3 6.3 7.7 - 73 63 80 - 5.9 7.9 38.8 - 2
GPCRdb Mean A Acetylcholine (muscarinic) ACM1 M1 - - - 1' - - - 7.6 - - - 7.7 - - - 80 - - - 38.8 - 3
GPCRdb Mean A Acetylcholine (muscarinic) ACM1 M1 - - - 1' - - - 1' - - - 1' - - - 1' - - - 1' - 4
GPCRdb Mean A Acetylcholine (muscarinic) ACM2 M2 - 2' 1' 2' - 5.2 7.8 5.9 4.8 5.7 7.9 6.2 5.2 38 74 61 36 2.6 29.9 70.3 1.8 1
Bouvier GEMTA A Acetylcholine (muscarinic) ACM2 M2 acetylcholine Physiological 2' 1' 2' - 5.6 8.3 6.0 - 6.1 8.4 6.5 - 34 68 52 - 2.9 56.1 137.2 - Bouvier
Inoue TGF A Acetylcholine (muscarinic) ACM2 M2 acetylcholine Physiological 2' 1' 2' - 4.8 7.3 5.8 4.8 5.2 7.4 6.0 5.2 43 80 70 36 2.4 3.8 3.4 1.8 Inoue
GPCRdb Mean A Acetylcholine (muscarinic) ACM2 M2 - 2' 1' 2' - 5.2 7.8 5.9 - 5.7 7.9 6.2 - 38 74 61 - 2.6 29.9 70.3 - 2
GPCRdb Mean A Acetylcholine (muscarinic) ACM2 M2 - 2' 1' 2' - 5.2 7.8 5.9 - 5.7 7.9 6.2 - 38 74 61 - 2.6 29.9 70.3 - 3
GPCRdb Mean A Acetylcholine (muscarinic) ACM2 M2 - 2' 1' 2' - 2' 1' 2' - 2' 1' 2' - 2' 1' 2' - 2' 1' 2' - 4
GPCRdb Mean A Dopamine DRD2 D2 - - 1' - - - 7.9 5.3 - - 8.2 7.0 - - 62 2 - - 50.0 1.1 - 1
Bouvier GEMTA A Dopamine DRD2 D2 dopamine Physiological - 1' - - - 8.2 5.3 - - 8.4 7.0 - - 61 2 - - 58.7 1.1 - Bouvier
Inoue TGF A Dopamine DRD2 D2 dopamine Physiological - 1' - - - 7.7 - - - 7.9 - - - 64 - - - 41.3 - - Inoue
GPCRdb Mean A Dopamine DRD2 D2 - - 1' - - - 7.9 - - - 8.2 - - - 62 - - - 50.0 - - 2
GPCRdb Mean A Dopamine DRD2 D2 - - 1' - - - 7.9 - - - 8.2 - - - 62 - - - 50.0 - - 3
GPCRdb Mean A Dopamine DRD2 D2 - - 1' - - - 1' - - - 1' - - - 1' - - - 1' - - 4
GPCRdb Mean A Acetylcholine (muscarinic) ACM3 M3 - - - 1' - 7.0 6.6 7.8 6.7 7.0 6.8 8.0 6.8 88 56 80 82 18.8 15.8 40.7 15.8 1
Bouvier GEMTA A Acetylcholine (muscarinic) ACM3 M3 acetylcholine Physiological - - 1' - - 5.4 7.4 - - 5.9 7.5 - - 30 93 - - 21.0 71.4 - Bouvier
Inoue TGF A Acetylcholine (muscarinic) ACM3 M3 acetylcholine Physiological - - 1' - 7.0 7.7 8.2 6.7 7.0 7.8 8.4 6.8 88 83 68 82 18.8 10.5 10.0 15.8 Inoue
GPCRdb Mean A Acetylcholine (muscarinic) ACM3 M3 - - - 1' - - 6.6 7.8 - - 6.8 8.0 - - 56 80 - - 15.8 40.7 - 2
GPCRdb Mean A Acetylcholine (muscarinic) ACM3 M3 - - - 1' - - - 7.8 - - - 8.0 - - - 80 - - - 40.7 - 3
GPCRdb Mean A Acetylcholine (muscarinic) ACM3 M3 - - - 1' - - - 1' - - - 1' - - - 1' - - - 1' - 4
GPCRdb Mean A Acetylcholine (muscarinic) ACM4 M4 - - 1' - - 5.2 7.9 5.8 5.3 5.8 8.1 6.2 5.8 29 70 47 28 3.3 19.6 19.8 2.8 1
Bouvier GEMTA A Acetylcholine (muscarinic) ACM4 M4 acetylcholine Physiological - 1' - - - 8.4 5.5 - - 8.6 6.1 - - 70 36 - - 31.7 36.3 - Bouvier
Inoue TGF A Acetylcholine (muscarinic) ACM4 M4 acetylcholine Physiological - 1' - - 5.2 7.4 6.2 5.3 5.8 7.6 6.4 5.8 29 71 58 28 3.3 7.5 3.3 2.8 Inoue
GPCRdb Mean A Acetylcholine (muscarinic) ACM4 M4 - - 1' - - - 7.9 5.8 - - 8.1 6.2 - - 70 47 - - 19.6 19.8 - 2
GPCRdb Mean A Acetylcholine (muscarinic) ACM4 M4 - - 1' - - - 7.9 - - - 8.1 - - - 70 - - - 19.6 - - 3
GPCRdb Mean A Acetylcholine (muscarinic) ACM4 M4 - - 1' - - - 1' - - - 1' - - - 1' - - - 1' - - 4
GPCRdb Mean A Acetylcholine (muscarinic) ACM5 M5 - - - 1' - 7.5 8.1 8.3 7.0 7.5 8.2 8.5 7.1 92 77 64 90 15.1 10.2 7.0 10.6 1
Inoue TGF A Acetylcholine (muscarinic) ACM5 M5 acetylcholine Physiological - - 1' - 7.5 8.1 8.3 7.0 7.5 8.2 8.5 7.1 92 77 64 90 15.1 10.2 7.0 10.6 Inoue
GPCRdb Mean A Acetylcholine (muscarinic) ACM5 M5 - - - 1' - - - 8.3 - - - 8.5 - - - 64 - - - 7.0 - 2
GPCRdb Mean A Acetylcholine (muscarinic) ACM5 M5 - - - 1' - - - 1' - - - 1' - - - 1' - - - 1' - 3
GPCRdb Mean A Acetylcholine (muscarinic) ACM5 M5 - - - 1' - - - 1' - - - 1' - - - 1' - - - 1' - 4
GPCRdb Mean A Adrenoceptors ADA1A α1A-adrenoceptor - - - 1' 2' 7.5 6.5 7.7 7.0 7.7 7.2 7.8 7.1 63 44 82 78 5.4 6.1 24.4 8.2 1
Bouvier GEMTA A Adrenoceptors ADA1A α1A-adrenoceptor noradrenaline Physiological - - 1' 2' 6.6 6.2 7.5 - 6.8 7.3 7.5 - 57 8 92 - 2.8 1.7 42.7 - Bouvier
Inoue TGF A Adrenoceptors ADA1A α1A-adrenoceptor (-)-noradrenaline Physiological - - 1' 2' 8.4 6.8 7.9 7.0 8.5 7.0 8.1 7.1 69 81 73 78 8.1 10.6 6.0 8.2 Inoue
GPCRdb Mean A Adrenoceptors ADA1A α1A-adrenoceptor - - - 1' 2' 7.5 6.5 7.7 7.0 7.7 7.2 7.8 7.1 63 44 82 78 5.4 6.1 24.4 8.2 2
GPCRdb Mean A Adrenoceptors ADA1A α1A-adrenoceptor - - - 1' 2' - - 7.7 2' - - 7.8 2' - - 82 2' - - 24.4 2' 3
GPCRdb Mean A Adrenoceptors ADA1A α1A-adrenoceptor - - - 1' 2' - - 1' 2' - - 1' 2' - - 1' 2' - - 1' 2' 4
GPCRdb Mean A Adrenoceptors ADA1B α1B-adrenoceptor - - - 1' - 7.6 5.6 7.0 5.6 7.7 6.0 7.2 6.1 85 41 76 35 11.5 3.5 4.5 2.4 1
Inoue TGF A Adrenoceptors ADA1B α1B-adrenoceptor (-)-noradrenaline Physiological - - 1' - 7.6 5.6 7.0 5.6 7.7 6.0 7.2 6.1 85 41 76 35 11.5 3.5 4.5 2.4 Inoue
GPCRdb Mean A Adrenoceptors ADA1B α1B-adrenoceptor - - - 1' - - - 7.0 - - - 7.2 - - - 76 - - - 4.5 - 2
GPCRdb Mean A Adrenoceptors ADA1B α1B-adrenoceptor - - - 1' - - - 1' - - - 1' - - - 1' - - - 1' - 3
GPCRdb Mean A Adrenoceptors ADA1B α1B-adrenoceptor - - - 1' - - - 1' - - - 1' - - - 1' - - - 1' - 4
GPCRdb Mean A Adrenoceptors ADA1D α1D-adrenoceptor - - - 1' - 6.3 - 6.4 - 6.8 - 6.9 - 34 - 36 - 7.1 - 3.3 - 1
Inoue TGF A Adrenoceptors ADA1D α1D-adrenoceptor (-)-noradrenaline Physiological - - 1' - 6.3 - 6.4 - 6.8 - 6.9 - 34 - 36 - 7.1 - 3.3 - Inoue
GPCRdb Mean A Adrenoceptors ADA1D α1D-adrenoceptor - - - 1' - - - 6.4 - - - 6.9 - - - 36 - - - 3.3 - 2
GPCRdb Mean A Adrenoceptors ADA1D α1D-adrenoceptor - - - 1' - - - 1' - - - 1' - - - 1' - - - 1' - 3
GPCRdb Mean A Adrenoceptors ADA1D α1D-adrenoceptor - - - 1' - - - 1' - - - 1' - - - 1' - - - 1' - 4
GPCRdb Mean A Adrenoceptors ADA2A α2A-adrenoceptor - 2' 1' - - 5.2 8.4 5.5 6.0 5.8 8.6 6.1 6.2 32 74 48 68 2.8 10.7 9.2 42.7 1
Bouvier GEMTA A Adrenoceptors ADA2A α2A-adrenoceptor noradrenaline Physiological 2' 1' - - 5.3 8.8 5.0 5.7 5.9 9.0 5.9 6.0 28 68 25 60 3.1 14.7 13.4 79.0 Bouvier
Inoue TGF A Adrenoceptors ADA2A α2A-adrenoceptor (-)-noradrenaline Physiological 2' 1' - - 5.2 8.0 6.0 6.3 5.7 8.1 6.2 6.4 37 81 70 76 2.4 6.7 5.0 6.4 Inoue
GPCRdb Mean A Adrenoceptors ADA2A α2A-adrenoceptor - 2' 1' - - 5.2 8.4 5.5 6.0 5.8 8.6 6.1 6.2 32 74 48 68 2.8 10.7 9.2 42.7 2
GPCRdb Mean A Adrenoceptors ADA2A α2A-adrenoceptor - 2' 1' - - 5.2 8.4 - - 5.8 8.6 - - 32 74 - - 2.8 10.7 - - 3
GPCRdb Mean A Adrenoceptors ADA2A α2A-adrenoceptor - 2' 1' - - 2' 1' - - 2' 1' - - 2' 1' - - 2' 1' - - 4
GPCRdb Mean A Adrenoceptors ADA2B α2B-adrenoceptor - 2' 1' - - 6.2 8.0 6.2 7.3 6.5 8.1 6.7 7.5 44 64 40 70 3.4 14.8 27.0 4.5 1
Bouvier GEMTA A Adrenoceptors ADA2B α2B-adrenoceptor noradrenaline Physiological 2' 1' - - - 8.0 5.9 - - 8.2 6.5 - - 56 25 - - 23.0 50.2 - Bouvier
Inoue TGF A Adrenoceptors ADA2B α2B-adrenoceptor (-)-noradrenaline Physiological 2' 1' - - 6.2 8.0 6.6 7.3 6.5 8.1 6.9 7.5 44 72 55 70 3.4 6.7 3.7 4.5 Inoue
GPCRdb Mean A Adrenoceptors ADA2B α2B-adrenoceptor - 2' 1' - - 6.2 8.0 6.2 - 6.5 8.1 6.7 - 44 64 40 - 3.4 14.8 27.0 - 2
GPCRdb Mean A Adrenoceptors ADA2B α2B-adrenoceptor - 2' 1' - - 2' 8.0 - - 2' 8.1 - - 2' 64 - - 2' 14.8 - - 3
GPCRdb Mean A Adrenoceptors ADA2B α2B-adrenoceptor - 2' 1' - - 2' 1' - - 2' 1' - - 2' 1' - - 2' 1' - - 4
GPCRdb Mean A Adrenoceptors ADA2C α2C-adrenoceptor - 2' 1' - - - 8.0 5.3 5.3 - 8.2 6.3 6.6 - 60 14 5 - 16.5 4.0 4.4 1
Bouvier GEMTA A Adrenoceptors ADA2C α2C-adrenoceptor noradrenaline Physiological 2' 1' - - - 9.2 5.2 5.3 - 9.4 6.2 6.6 - 65 12 5 - 26.5 6.8 4.4 Bouvier
Inoue TGF A Adrenoceptors ADA2C α2C-adrenoceptor (-)-noradrenaline Physiological 2' 1' - - - 6.8 5.5 - - 7.1 6.4 - - 55 15 - - 6.5 1.1 - Inoue
GPCRdb Mean A Adrenoceptors ADA2C α2C-adrenoceptor - 2' 1' - - 2' 8.0 5.3 - 2' 8.2 6.3 - 2' 60 14 - 2' 16.5 4.0 - 2
GPCRdb Mean A Adrenoceptors ADA2C α2C-adrenoceptor - 2' 1' - - 2' 8.0 - - 2' 8.2 - - 2' 60 - - 2' 16.5 - - 3
GPCRdb Mean A Adrenoceptors ADA2C α2C-adrenoceptor - 2' 1' - - 2' 1' - - 2' 1' - - 2' 1' - - 2' 1' - - 4
GPCRdb Mean A Adrenoceptors ADRB1 β1-adrenoceptor - 1' 2' - - 8.7 6.3 6.8 6.0 8.8 7.0 7.3 6.7 76 27 44 29 8.0 4.5 15.8 6.6 1
Bouvier GEMTA A Adrenoceptors ADRB1 β1-adrenoceptor noradrenaline Physiological 1' 2' - - 9.6 6.1 6.1 5.8 9.7 6.7 6.9 6.2 84 30 31 46 7.5 4.7 23.0 11.8 Bouvier
Inoue TGF A Adrenoceptors ADRB1 β1-adrenoceptor (−)-Isoproterenol hydrochloride Surrogate 1' 2' - - 7.8 6.5 7.5 6.3 8.0 7.2 7.7 7.2 67 24 58 12 8.4 4.3 8.7 1.4 Inoue
GPCRdb Mean A Adrenoceptors ADRB1 β1-adrenoceptor - 1' 2' - - 8.7 6.3 6.8 6.0 8.8 7.0 7.3 6.7 76 27 44 29 8.0 4.5 15.8 6.6 2
GPCRdb Mean A Adrenoceptors ADRB1 β1-adrenoceptor - 1' 2' - - 8.7 6.3 - - 8.8 7.0 - - 76 27 - - 8.0 4.5 - - 3
GPCRdb Mean A Adrenoceptors ADRB1 β1-adrenoceptor - 1' 2' - - 1' 2' - - 1' 2' - - 1' 2' - - 1' 2' - - 4
GPCRdb Mean A Adrenoceptors ADRB2 β2-adrenoceptor - 1' 2' - - 7.2 5.8 7.1 - 7.4 6.4 7.5 - 70 29 49 - 4.8 - 28.6 - 1
Bouvier GEMTA A Adrenoceptors ADRB2 β2-adrenoceptor noradrenaline Physiological 1' 2' - - 8.2 - 6.3 - 8.3 - 6.5 - 83 - 72 - 3.3 - 55.8 - Bouvier
Inoue TGF A Adrenoceptors ADRB2 β2-adrenoceptor (−)-Isoproterenol hydrochloride Surrogate 1' 2' - - 6.8 - 6.6 - 7.3 - 7.2 - 30 - 24 - 6.4 - 1.5 - Inoue
Roth TGF A Adrenoceptors ADRB2 β2-adrenoceptor (-)-adrenaline Physiological 1' 2' - - 6.6 5.8 8.5 - 6.6 6.4 8.8 - 97 29 52 - - - - - Roth
GPCRdb Mean A Adrenoceptors ADRB2 β2-adrenoceptor - 1' 2' - - 7.2 5.8 7.1 - 7.4 6.4 7.5 - 70 29 49 - 4.8 2' 28.6 - 2
GPCRdb Mean A Adrenoceptors ADRB2 β2-adrenoceptor - 1' 2' - - 7.2 2' 7.1 - 7.4 2' 7.5 - 70 2' 49 - 4.8 2' - - 3
GPCRdb Mean A Adrenoceptors ADRB2 β2-adrenoceptor - 1' 2' - - 7.2 2' - - 7.4 2' - - 70 2' - - 1' 2' - - 4
GPCRdb Mean A Adrenoceptors ADRB3 β3-adrenoceptor - 1' 2' - - 4.9 - - - 5.3 - - - 44 - - - 7.7 - - - 1
Inoue TGF A Adrenoceptors ADRB3 β3-adrenoceptor (−)-Isoproterenol hydrochloride Surrogate 1' 2' - - 4.9 - - - 5.3 - - - 44 - - - 7.7 - - - Inoue
GPCRdb Mean A Adrenoceptors ADRB3 β3-adrenoceptor - 1' 2' - - 4.9 2' - - 5.3 2' - - 44 2' - - 7.7 2' - - 2
GPCRdb Mean A Adrenoceptors ADRB3 β3-adrenoceptor - 1' 2' - - 1' 2' - - 1' 2' - - 1' 2' - - 1' 2' - - 3
GPCRdb Mean A Adrenoceptors ADRB3 β3-adrenoceptor - 1' 2' - - 1' 2' - - 1' 2' - - 1' 2' - - 1' 2' - - 4
GPCRdb Mean A Dopamine DRD1 D1 - 1' - - - 6.9 5.2 6.2 - 7.2 5.7 6.6 - 56 36 52 - 5.7 5.5 28.6 - 1
Bouvier GEMTA A Dopamine DRD1 D1 dopamine Physiological 1' - - - 8.6 5.4 7.4 - 8.8 5.8 7.7 - 65 42 60 - 3.2 8.2 52.9 - Bouvier
Inoue TGF A Dopamine DRD1 D1 dopamine Physiological 1' - - - 5.2 5.0 5.1 - 5.5 5.6 5.5 - 48 29 43 - 8.1 2.8 4.3 - Inoue
GPCRdb Mean A Dopamine DRD1 D1 - 1' - - - 6.9 5.2 6.2 - 7.2 5.7 6.6 - 56 36 52 - 5.7 5.5 28.6 - 2
GPCRdb Mean A Dopamine DRD1 D1 - 1' - - - 6.9 - - - 7.2 - - - 56 - - - 5.7 - - - 3
GPCRdb Mean A Dopamine DRD1 D1 - 1' - - - 1' - - - 1' - - - 1' - - - 1' - - - 4
GPCRdb Mean A Dopamine DRD3 D3 - - 1' - - - 7.2 - - - 7.8 - - - 25 - - - 3.2 - - 1
Inoue TGF A Dopamine DRD3 D3 dopamine Physiological - 1' - - - 7.2 - - - 7.8 - - - 25 - - - 3.2 - - Inoue
GPCRdb Mean A Dopamine DRD3 D3 - - 1' - - - 7.2 - - - 7.8 - - - 25 - - - 3.2 - - 2
GPCRdb Mean A Dopamine DRD3 D3 - - 1' - - - 1' - - - 1' - - - 1' - - - 1' - - 3
GPCRdb Mean A Dopamine DRD3 D3 - - 1' - - - 1' - - - 1' - - - 1' - - - 1' - - 4
GPCRdb Mean A Dopamine DRD4 D4 - - 1' - - - 7.3 - - - 7.5 - - - 66 - - - 279.5 - - 1
Inoue TGF A Dopamine DRD4 D4 dopamine Physiological - 1' - - - 7.3 - - - 7.5 - - - 66 - - - 279.5 - - Inoue
GPCRdb Mean A Dopamine DRD4 D4 - - 1' - - - 7.3 - - - 7.5 - - - 66 - - - 279.5 - - 2
GPCRdb Mean A Dopamine DRD4 D4 - - 1' - - - 1' - - - 1' - - - 1' - - - 1' - - 3
GPCRdb Mean A Dopamine DRD4 D4 - - 1' - - - 1' - - - 1' - - - 1' - - - 1' - - 4
GPCRdb Mean A Dopamine DRD5 D5 - 1' - - - 7.3 5.5 6.9 5.6 7.7 6.5 7.3 6.6 53 15 50 10 6.0 4.5 20.2 1.2 1
Bouvier GEMTA A Dopamine DRD5 D5 dopamine Physiological 1' - - - 8.4 5.3 7.7 - 8.6 6.6 7.9 - 76 8 72 - 7.8 6.2 36.9 - Bouvier
Inoue TGF A Dopamine DRD5 D5 dopamine Physiological 1' - - - 6.2 5.7 6.1 5.6 6.7 6.4 6.7 6.6 30 22 27 10 4.3 2.7 3.6 1.2 Inoue
GPCRdb Mean A Dopamine DRD5 D5 - 1' - - - 7.3 5.5 6.9 - 7.7 6.5 7.3 - 53 15 50 - 6.0 4.5 20.2 - 2
GPCRdb Mean A Dopamine DRD5 D5 - 1' - - - 7.3 - - - 7.7 - - - 53 - - - 6.0 - - - 3
GPCRdb Mean A Dopamine DRD5 D5 - 1' - - - 1' - - - 1' - - - 1' - - - 1' - - - 4
GPCRdb Mean A Histamine HRH1 H1 - - - 1' - 6.3 7.0 7.5 6.0 6.5 7.2 8.0 6.2 58 72 44 52 4.5 20.6 19.2 7.7 1
Bouvier GEMTA A Histamine HRH1 H1 histamine Physiological - - 1' - 5.5 6.5 7.8 6.0 5.8 6.6 8.2 6.2 49 91 52 56 2.9 37.9 35.7 11.2 Bouvier
Inoue TGF A Histamine HRH1 H1 histamine Physiological - - 1' - 7.1 7.4 7.3 5.9 7.3 7.7 7.8 6.2 66 52 37 48 6.0 3.4 2.6 4.2 Inoue
GPCRdb Mean A Histamine HRH1 H1 - - - 1' - 6.3 7.0 7.5 6.0 6.5 7.2 8.0 6.2 58 72 44 52 4.5 20.6 19.2 7.7 2
GPCRdb Mean A Histamine HRH1 H1 - - - 1' - - - 7.5 - - - 8.0 - - - 44 - - - 19.2 - 3
GPCRdb Mean A Histamine HRH1 H1 - - - 1' - - - 1' - - - 1' - - - 1' - - - 1' - 4
GPCRdb Mean A Histamine HRH2 H2 - 2' - 1' - 6.3 4.5 5.7 4.8 6.5 5.4 6.2 5.4 62 20 41 29 3.5 8.9 25.1 5.3 1
Bouvier GEMTA A Histamine HRH2 H2 histamine Physiological 2' - 1' - 7.0 4.1 6.5 4.6 7.1 5.1 6.7 5.0 79 12 65 46 3.5 15.7 49.3 9.9 Bouvier
Inoue TGF A Histamine HRH2 H2 histamine Physiological 2' - 1' - 5.7 5.0 4.9 4.9 6.0 5.7 5.7 5.8 44 28 17 12 3.4 2.1 0.9 0.7 Inoue
GPCRdb Mean A Histamine HRH2 H2 - 2' - 1' - 6.3 4.5 5.7 4.8 6.5 5.4 6.2 5.4 62 20 41 29 3.5 8.9 25.1 5.3 2
GPCRdb Mean A Histamine HRH2 H2 - 2' - 1' - 6.3 - 5.7 - 6.5 - 6.2 - 62 - 41 - 3.5 - 25.1 - 3
GPCRdb Mean A Histamine HRH2 H2 - 2' - 1' - 2' - 1' - 2' - 1' - 2' - 1' - 2' - 1' - 4
GPCRdb Mean A Histamine HRH3 H3 - - 1' - - - 6.3 5.6 4.9 - 6.6 6.1 5.8 - 62 30 13 - 10.8 5.0 2.4 1
Inoue TGF A Histamine HRH3 H3 histamine Physiological - 1' - - - 6.3 5.6 4.9 - 6.6 6.1 5.8 - 62 30 13 - 10.8 5.0 2.4 Inoue
GPCRdb Mean A Histamine HRH3 H3 - - 1' - - - 6.3 - - - 6.6 - - - 62 - - - 10.8 - - 2
GPCRdb Mean A Histamine HRH3 H3 - - 1' - - - 1' - - - 1' - - - 1' - - - 1' - - 3
GPCRdb Mean A Histamine HRH3 H3 - - 1' - - - 1' - - - 1' - - - 1' - - - 1' - - 4
GPCRdb Mean A Histamine HRH4 H4 - - 1' - - 5.3 6.4 5.8 5.6 6.6 7.1 6.8 6.7 6 26 9 8 0.9 3.2 1.1 1.3 1
Inoue TGF A Histamine HRH4 H4 histamine Physiological - 1' - - 5.3 6.4 5.8 5.6 6.6 7.1 6.8 6.7 6 26 9 8 0.9 3.2 1.1 1.3 Inoue
GPCRdb Mean A Histamine HRH4 H4 - - 1' - - - 6.4 - - - 7.1 - - - 26 - - - 3.2 - - 2
GPCRdb Mean A Histamine HRH4 H4 - - 1' - - - 1' - - - 1' - - - 1' - - - 1' - - 3
GPCRdb Mean A Histamine HRH4 H4 - - 1' - - - 1' - - - 1' - - - 1' - - - 1' - - 4
GPCRdb Mean A Trace amine TAAR1 TA1 - 1' - 2' - - - - - - - - - - - - - - - - - 1
GPCRdb Mean A Trace amine TAAR1 TA1 - 1' - 2' - 1' - 2' - 1' - 2' - 1' - 2' - 1' - 2' - 2
GPCRdb Mean A Trace amine TAAR1 TA1 - 1' - 2' - 1' - 2' - 1' - 2' - 1' - 2' - 1' - 2' - 3
GPCRdb Mean A Trace amine TAAR1 TA1 - 1' - 2' - 1' - 2' - 1' - 2' - 1' - 2' - 1' - 2' - 4
GPCRdb Mean A Angiotensin AGTR1 AT1 - - 1' 1' - 8.9 8.2 9.4 9.0 9.1 8.8 9.8 9.2 50 33 52 78 9.8 9.2 21.4 27.8 1
Bouvier GEMTA A Angiotensin AGTR1 AT1 angiotensin II Physiological - 1' 1' - - 7.1 8.6 8.8 - 8.2 9.1 8.9 - 8 33 91 - 2.8 29.5 29.2 Bouvier
Inoue TGF A Angiotensin AGTR1 AT1 angiotensin II Physiological - 1' 1' - 8.9 9.3 10.3 9.2 9.1 9.5 10.4 9.4 50 58 71 64 9.8 15.6 13.3 26.4 Inoue
GPCRdb Mean A Angiotensin AGTR1 AT1 - - 1' 1' - - 8.2 9.4 9.0 - 8.8 9.8 9.2 - 33 52 78 - 9.2 21.4 27.8 2
GPCRdb Mean A Angiotensin AGTR1 AT1 - - 1' 1' - - 8.2 9.4 - - 8.8 9.8 - - 33 52 - - 9.2 21.4 - 3
GPCRdb Mean A Angiotensin AGTR1 AT1 - - 1' 1' - - 1' 1' - - 1' 1' - - 1' 1' - - 1' 1' - 4
GPCRdb Mean A Angiotensin AGTR2 AT2 - - 1' - - - - - - - - - - - - - - - - - - 1
GPCRdb Mean A Angiotensin AGTR2 AT2 - - 1' - - - 1' - - - 1' - - - 1' - - - 1' - - 2
GPCRdb Mean A Angiotensin AGTR2 AT2 - - 1' - - - 1' - - - 1' - - - 1' - - - 1' - - 3
GPCRdb Mean A Angiotensin AGTR2 AT2 - - 1' - - - 1' - - - 1' - - - 1' - - - 1' - - 4
GPCRdb Mean A Apelin APJ apelin - - 1' - - - 8.1 6.2 6.2 - 8.4 7.4 7.2 - 46 10 12 - 16.7 1.9 6.2 1
Bouvier GEMTA A Apelin APJ apelin [Pyr1]apelin-13 Physiological - 1' - - - 9.1 5.8 6.7 - 9.3 7.3 7.7 - 48 4 12 - 20.1 2.2 7.4 Bouvier
Inoue TGF A Apelin APJ apelin apelin-13 Physiological - 1' - - - 7.0 6.6 5.7 - 7.4 7.5 6.6 - 45 15 12 - 13.3 1.6 5.0 Inoue
GPCRdb Mean A Apelin APJ apelin - - 1' - - - 8.1 6.2 6.2 - 8.4 7.4 7.2 - 46 10 12 - 16.7 1.9 6.2 2
GPCRdb Mean A Apelin APJ apelin - - 1' - - - 8.1 - - - 8.4 - - - 46 - - - 16.7 - - 3
GPCRdb Mean A Apelin APJ apelin - - 1' - - - 1' - - - 1' - - - 1' - - - 1' - - 4
GPCRdb Mean A Bombesin NMBR BB1 - - - 1' - 9.8 10.1 10.0 10.1 10.0 10.2 10.3 10.2 63 66 62 62 9.4 8.5 5.0 7.5 1
Inoue TGF A Bombesin NMBR BB1 neuromedin B Physiological - - 1' - 9.8 10.1 10.0 10.1 10.0 10.2 10.3 10.2 63 66 62 62 9.4 8.5 5.0 7.5 Inoue
GPCRdb Mean A Bombesin NMBR BB1 - - - 1' - - - 10.0 - - - 10.3 - - - 62 - - - 5.0 - 2
GPCRdb Mean A Bombesin NMBR BB1 - - - 1' - - - 1' - - - 1' - - - 1' - - - 1' - 3
GPCRdb Mean A Bombesin NMBR BB1 - - - 1' - - - 1' - - - 1' - - - 1' - - - 1' - 4
GPCRdb Mean A Bombesin GRPR BB2 - - - 1' - 9.6 9.6 9.8 9.9 9.7 9.7 10.0 10.1 78 74 69 82 6.5 4.3 2.9 6.5 1
Inoue TGF A Bombesin GRPR BB2 Bombesin Physiological - - 1' - 9.6 9.6 9.8 9.9 9.7 9.7 10.0 10.1 78 74 69 82 6.5 4.3 2.9 6.5 Inoue
GPCRdb Mean A Bombesin GRPR BB2 - - - 1' - - - 9.8 - - - 10.0 - - - 69 - - - 2.9 - 2
GPCRdb Mean A Bombesin GRPR BB2 - - - 1' - - - 1' - - - 1' - - - 1' - - - 1' - 3
GPCRdb Mean A Bombesin GRPR BB2 - - - 1' - - - 1' - - - 1' - - - 1' - - - 1' - 4
GPCRdb Mean A Bombesin BRS3 BB3 - - - 1' - - - - - - - - - - - - - - - - - 1
GPCRdb Mean A Bombesin BRS3 BB3 - - - 1' - - - 1' - - - 1' - - - 1' - - - 1' - 2
GPCRdb Mean A Bombesin BRS3 BB3 - - - 1' - - - 1' - - - 1' - - - 1' - - - 1' - 3
GPCRdb Mean A Bombesin BRS3 BB3 - - - 1' - - - 1' - - - 1' - - - 1' - - - 1' - 4
GPCRdb Mean A Bradykinin BKRB1 B1 - - 1' 1' - 7.3 6.8 7.0 7.4 7.8 7.4 7.8 7.8 38 28 20 40 3.4 3.3 10.8 3.3 1
Bouvier GEMTA A Bradykinin BKRB1 B1 kallidin Physiological - 1' 1' - - 5.9 6.2 - - 6.8 7.0 - - 17 18 - - 3.8 19.5 - Bouvier
Inoue TGF A Bradykinin BKRB1 B1 bradykinin Physiological - 1' 1' - 7.3 7.7 7.8 7.4 7.8 8.1 8.5 7.8 38 38 23 40 3.4 2.9 2.2 3.3 Inoue
GPCRdb Mean A Bradykinin BKRB1 B1 - - 1' 1' - - 6.8 7.0 - - 7.4 7.8 - - 28 20 - - 3.3 10.8 - 2
GPCRdb Mean A Bradykinin BKRB1 B1 - - 1' 1' - - 6.8 7.0 - - 7.4 7.8 - - 28 20 - - 3.3 10.8 - 3
GPCRdb Mean A Bradykinin BKRB1 B1 - - 1' 1' - - 1' 1' - - 1' 1' - - 1' 1' - - 1' 1' - 4
GPCRdb Mean A Bradykinin BKRB2 B2 - 1' 1' 1' - 8.1 8.7 9.7 9.4 8.3 8.9 9.8 9.6 52 63 80 72 6.5 9.4 44.4 21.0 1
Bouvier GEMTA A Bradykinin BKRB2 B2 kallidin Physiological 1' 1' 1' - - 7.8 9.3 9.5 - 8.1 9.4 9.7 - 52 91 68 - 10.8 80.3 27.5 Bouvier
Inoue TGF A Bradykinin BKRB2 B2 kallidin Physiological 1' 1' 1' - 8.1 9.5 10.1 9.3 8.3 9.7 10.2 9.4 52 74 69 76 6.5 7.9 8.4 14.5 Inoue
GPCRdb Mean A Bradykinin BKRB2 B2 - 1' 1' 1' - 8.1 8.7 9.7 9.4 8.3 8.9 9.8 9.6 52 63 80 72 6.5 9.4 44.4 21.0 2
GPCRdb Mean A Bradykinin BKRB2 B2 - 1' 1' 1' - 1' 8.7 9.7 - 1' 8.9 9.8 - 1' 63 80 - 1' 9.4 44.4 - 3
GPCRdb Mean A Bradykinin BKRB2 B2 - 1' 1' 1' - 1' 1' 1' - 1' 1' 1' - 1' 1' 1' - 1' 1' 1' - 4
GPCRdb Mean A Cholecystokinin CCKAR CCK1 - 2' - 1' - 9.2 9.5 10.1 10.0 9.4 9.7 10.2 10.1 70 74 83 93 8.7 31.8 98.3 15.3 1
Bouvier GEMTA A Cholecystokinin CCKAR CCK1 CCK-8 Physiological 2' - 1' - 8.1 8.5 9.4 9.8 8.5 8.8 9.6 9.9 40 49 68 88 4.3 48.3 186.6 25.6 Bouvier
Inoue TGF A Cholecystokinin CCKAR CCK1 CCK-8 Physiological 2' - 1' - 10.4 10.5 10.8 10.2 10.4 10.5 10.8 10.2 100 99 98 98 13.1 15.4 10.1 5.0 Inoue
GPCRdb Mean A Cholecystokinin CCKAR CCK1 - 2' - 1' - 9.2 9.5 10.1 10.0 9.4 9.7 10.2 10.1 70 74 83 93 8.7 31.8 98.3 15.3 2
GPCRdb Mean A Cholecystokinin CCKAR CCK1 - 2' - 1' - 9.2 - 10.1 - 9.4 - 10.2 - 70 - 83 - 8.7 - 98.3 - 3
GPCRdb Mean A Cholecystokinin CCKAR CCK1 - 2' - 1' - 2' - 1' - 2' - 1' - 2' - 1' - 2' - 1' - 4
GPCRdb Mean A Cholecystokinin GASR CCK2 - - - 1' - 9.8 9.7 10.1 9.6 9.9 9.9 10.3 9.7 72 70 67 72 12.6 11.2 7.0 29.0 1
Inoue TGF A Cholecystokinin GASR CCK2 CCK-8 Physiological - - 1' - 9.8 9.7 10.1 9.6 9.9 9.9 10.3 9.7 72 70 67 72 12.6 11.2 7.0 29.0 Inoue
GPCRdb Mean A Cholecystokinin GASR CCK2 - - - 1' - - - 10.1 - - - 10.3 - - - 67 - - - 7.0 - 2
GPCRdb Mean A Cholecystokinin GASR CCK2 - - - 1' - - - 1' - - - 1' - - - 1' - - - 1' - 3
GPCRdb Mean A Cholecystokinin GASR CCK2 - - - 1' - - - 1' - - - 1' - - - 1' - - - 1' - 4
GPCRdb Mean A Complement peptide C5AR1 C5a1 - - 1' 2' - - 9.0 9.3 - - 9.2 9.4 - - 67 66 - - 21.5 112.9 - 1
Bouvier GEMTA A Complement peptide C5AR1 C5a1 C5a Physiological - 1' 2' - - 9.0 9.3 - - 9.2 9.4 - - 67 66 - - 21.5 112.9 - Bouvier
GPCRdb Mean A Complement peptide C5AR1 C5a1 - - 1' 2' - - 9.0 9.3 - - 9.2 9.4 - - 67 66 - - 21.5 112.9 - 2
GPCRdb Mean A Complement peptide C5AR1 C5a1 - - 1' 2' - - 1' 2' - - 1' 2' - - 1' 2' - - 1' 2' - 3
GPCRdb Mean A Complement peptide C5AR1 C5a1 - - 1' 2' - - 1' 2' - - 1' 2' - - 1' 2' - - 1' 2' - 4
GPCRdb Mean A Endothelin EDNRA ETA - - - 1' - 8.9 10.0 9.8 10.2 9.2 10.1 9.9 10.4 61 90 78 76 6.9 20.2 52.8 18.1 1
Bouvier GEMTA A Endothelin EDNRA ETA endothelin-1 Physiological - - 1' - 8.1 9.8 9.3 10.3 8.6 9.9 9.5 10.6 35 85 65 58 2.4 28.5 97.3 22.4 Bouvier
Inoue TGF A Endothelin EDNRA ETA endothelin-1 Physiological - - 1' - 9.7 10.2 10.2 10.2 9.8 10.2 10.3 10.2 87 95 90 95 11.3 11.9 8.2 13.8 Inoue
GPCRdb Mean A Endothelin EDNRA ETA - - - 1' - 8.9 10.0 9.8 10.2 9.2 10.1 9.9 10.4 61 90 78 76 6.9 20.2 52.8 18.1 2
GPCRdb Mean A Endothelin EDNRA ETA - - - 1' - - - 9.8 - - - 9.9 - - - 78 - - - 52.8 - 3
GPCRdb Mean A Endothelin EDNRA ETA - - - 1' - - - 1' - - - 1' - - - 1' - - - 1' - 4
GPCRdb Mean A Endothelin EDNRB ETB - 1' 1' 1' - 9.6 10.2 9.9 10.2 9.7 10.3 10.1 10.3 64 82 68 81 4.9 4.7 5.7 6.8 1
Inoue TGF A Endothelin EDNRB ETB endothelin-1 Physiological 1' 1' 1' - 9.6 10.2 9.9 10.2 9.7 10.3 10.1 10.3 64 82 68 81 4.9 4.7 5.7 6.8 Inoue
GPCRdb Mean A Endothelin EDNRB ETB - 1' 1' 1' - 9.6 10.2 9.9 - 9.7 10.3 10.1 - 64 82 68 - 4.9 4.7 5.7 - 2
GPCRdb Mean A Endothelin EDNRB ETB - 1' 1' 1' - 1' 1' 1' - 1' 1' 1' - 1' 1' 1' - 1' 1' 1' - 3
GPCRdb Mean A Endothelin EDNRB ETB - 1' 1' 1' - 1' 1' 1' - 1' 1' 1' - 1' 1' 1' - 1' 1' 1' - 4
GPCRdb Mean A Formylpeptide FPR1 FPR1 - - 1' - - - 6.6 6.5 - - 7.4 7.2 - - 20 19 - - 1.7 1.5 - 1
Inoue TGF A Formylpeptide FPR1 FPR1 fMet-Leu-Phe Physiological - 1' - - - 6.6 6.5 - - 7.4 7.2 - - 20 19 - - 1.7 1.5 - Inoue
GPCRdb Mean A Formylpeptide FPR1 FPR1 - - 1' - - - 6.6 - - - 7.4 - - - 20 - - - 1.7 - - 2
GPCRdb Mean A Formylpeptide FPR1 FPR1 - - 1' - - - 1' - - - 1' - - - 1' - - - 1' - - 3
GPCRdb Mean A Formylpeptide FPR1 FPR1 - - 1' - - - 1' - - - 1' - - - 1' - - - 1' - - 4
GPCRdb Mean A Formylpeptide FPR2 FPR2/ALX - - 1' 2' - 5.1 6.3 6.1 5.7 6.2 6.7 6.7 6.6 6 46 33 12 1.1 7.7 3.1 6.5 1
Inoue TGF A Formylpeptide FPR2 FPR2/ALX WKYMVM Surrogate - 1' 2' - 5.1 6.3 6.1 5.7 6.2 6.7 6.7 6.6 6 46 33 12 1.1 7.7 3.1 6.5 Inoue
GPCRdb Mean A Formylpeptide FPR2 FPR2/ALX - - 1' 2' - - 6.3 6.1 - - 6.7 6.7 - - 46 33 - - 7.7 3.1 - 2
GPCRdb Mean A Formylpeptide FPR2 FPR2/ALX - - 1' 2' - - 1' 2' - - 1' 2' - - 1' 2' - - 1' 2' - 3
GPCRdb Mean A Formylpeptide FPR2 FPR2/ALX - - 1' 2' - - 1' 2' - - 1' 2' - - 1' 2' - - 1' 2' - 4
GPCRdb Mean A Formylpeptide FPR3 FPR3 - - 1' - - - - - - - - - - - - - - - - - - 1
GPCRdb Mean A Formylpeptide FPR3 FPR3 - - 1' - - - 1' - - - 1' - - - 1' - - - 1' - - 2
GPCRdb Mean A Formylpeptide FPR3 FPR3 - - 1' - - - 1' - - - 1' - - - 1' - - - 1' - - 3
GPCRdb Mean A Formylpeptide FPR3 FPR3 - - 1' - - - 1' - - - 1' - - - 1' - - - 1' - - 4
GPCRdb Mean A Galanin GALR1 GAL1 - - 1' - - 6.2 7.7 6.7 6.6 7.0 7.9 7.2 7.2 15 63 36 23 10.4 31.3 9.6 15.5 1
Inoue TGF A Galanin GALR1 GAL1 galanin Physiological - 1' - - 6.2 7.7 6.7 6.6 7.0 7.9 7.2 7.2 15 63 36 23 10.4 31.3 9.6 15.5 Inoue
GPCRdb Mean A Galanin GALR1 GAL1 - - 1' - - - 7.7 - - - 7.9 - - - 63 - - - 31.3 - - 2
GPCRdb Mean A Galanin GALR1 GAL1 - - 1' - - - 1' - - - 1' - - - 1' - - - 1' - - 3
GPCRdb Mean A Galanin GALR1 GAL1 - - 1' - - - 1' - - - 1' - - - 1' - - - 1' - - 4
GPCRdb Mean A Galanin GALR2 GAL2 - - 2' 1' 2' - 7.5 8.2 7.8 - 7.9 8.4 8.2 - 36 49 44 - 4.3 5.2 6.8 1
Inoue TGF A Galanin GALR2 GAL2 galanin Physiological - 2' 1' 2' - 7.5 8.2 7.8 - 7.9 8.4 8.2 - 36 49 44 - 4.3 5.2 6.8 Inoue
GPCRdb Mean A Galanin GALR2 GAL2 - - 2' 1' 2' - 7.5 8.2 7.8 - 7.9 8.4 8.2 - 36 49 44 - 4.3 5.2 6.8 2
GPCRdb Mean A Galanin GALR2 GAL2 - - 2' 1' 2' - 2' 1' 2' - 2' 1' 2' - 2' 1' 2' - 2' 1' 2' 3
GPCRdb Mean A Galanin GALR2 GAL2 - - 2' 1' 2' - 2' 1' 2' - 2' 1' 2' - 2' 1' 2' - 2' 1' 2' 4
GPCRdb Mean A Galanin GALR3 GAL3 - - 1' - - - 5.7 5.3 - - 6.3 6.2 - - 21 11 - - 2.4 0.7 - 1
Inoue TGF A Galanin GALR3 GAL3 Galanin (rat) Physiological - 1' - - - 5.7 5.3 - - 6.3 6.2 - - 21 11 - - 2.4 0.7 - Inoue
GPCRdb Mean A Galanin GALR3 GAL3 - - 1' - - - 5.7 - - - 6.3 - - - 21 - - - 2.4 - - 2
GPCRdb Mean A Galanin GALR3 GAL3 - - 1' - - - 1' - - - 1' - - - 1' - - - 1' - - 3
GPCRdb Mean A Galanin GALR3 GAL3 - - 1' - - - 1' - - - 1' - - - 1' - - - 1' - - 4
GPCRdb Mean A Ghrelin GHSR ghrelin - - 2' 1' 2' 9.4 8.8 9.1 9.4 9.8 9.4 9.8 9.9 39 32 24 40 7.5 6.0 7.5 7.4 1
Bouvier GEMTA A Ghrelin GHSR ghrelin ghrelin Physiological - 2' 1' 2' - 8.2 8.4 9.2 - 8.8 9.2 9.7 - 30 16 37 - 7.3 9.5 5.5 Bouvier
Inoue TGF A Ghrelin GHSR ghrelin MK 0677 Surrogate - 2' 1' 2' 9.4 9.5 9.7 9.7 9.8 10.0 10.3 10.1 39 34 32 44 7.5 4.7 5.5 9.3 Inoue
GPCRdb Mean A Ghrelin GHSR ghrelin - - 2' 1' 2' - 8.8 9.1 9.4 - 9.4 9.8 9.9 - 32 24 40 - 6.0 7.5 7.4 2
GPCRdb Mean A Ghrelin GHSR ghrelin - - 2' 1' 2' - 8.8 9.1 9.4 - 9.4 9.8 9.9 - 32 24 40 - 6.0 7.5 7.4 3
GPCRdb Mean A Ghrelin GHSR ghrelin - - 2' 1' 2' - 2' 1' 2' - 2' 1' 2' - 2' 1' 2' - 2' 1' 2' 4
GPCRdb Mean A Gonadotrophin-releasing hormone GNRHR GnRH1 - - 2' 1' - 9.2 8.4 9.1 - 9.5 8.9 9.4 - 56 34 45 - 9.3 3.5 12.3 - 1
Bouvier GEMTA A Gonadotrophin-releasing hormone GNRHR GnRH1 GnRH I Physiological - 2' 1' - - - 8.7 - - - 9.2 - - - 32 - - - 20.9 - Bouvier
Inoue TGF A Gonadotrophin-releasing hormone GNRHR GnRH1 Leuprolide Surrogate - 2' 1' - 9.2 8.4 9.4 - 9.5 8.9 9.6 - 56 34 58 - 9.3 3.5 3.8 - Inoue
GPCRdb Mean A Gonadotrophin-releasing hormone GNRHR GnRH1 - - 2' 1' - - 8.4 9.1 - - 8.9 9.4 - - 34 45 - - 3.5 12.3 - 2
GPCRdb Mean A Gonadotrophin-releasing hormone GNRHR GnRH1 - - 2' 1' - - 2' 9.1 - - 2' 9.4 - - 2' 45 - - 2' 12.3 - 3
GPCRdb Mean A Gonadotrophin-releasing hormone GNRHR GnRH1 - - 2' 1' - - 2' 1' - - 2' 1' - - 2' 1' - - 2' 1' - 4
GPCRdb Mean A Kisspeptin KISSR kisspeptin - - - 1' - 7.5 7.5 8.5 7.1 7.5 7.7 8.7 7.3 70 66 61 63 5.7 5.1 4.1 6.7 1
Inoue TGF A Kisspeptin KISSR kisspeptin kisspeptin-10 Physiological - - 1' - 7.5 7.5 8.5 7.1 7.5 7.7 8.7 7.3 70 66 61 63 5.7 5.1 4.1 6.7 Inoue
GPCRdb Mean A Kisspeptin KISSR kisspeptin - - - 1' - - - 8.5 - - - 8.7 - - - 61 - - - 4.1 - 2
GPCRdb Mean A Kisspeptin KISSR kisspeptin - - - 1' - - - 1' - - - 1' - - - 1' - - - 1' - 3
GPCRdb Mean A Kisspeptin KISSR kisspeptin - - - 1' - - - 1' - - - 1' - - - 1' - - - 1' - 4
GPCRdb Mean A Melanin-concentrating hormone MCHR1 MCH1 - 1' 1' 1' - 7.6 7.9 7.5 7.1 7.7 7.9 7.7 7.3 82 84 73 60 9.2 6.5 4.6 5.4 1
Inoue TGF A Melanin-concentrating hormone MCHR1 MCH1 melanin-concentrating hormone Physiological 1' 1' 1' - 7.6 7.9 7.5 7.1 7.7 7.9 7.7 7.3 82 84 73 60 9.2 6.5 4.6 5.4 Inoue
GPCRdb Mean A Melanin-concentrating hormone MCHR1 MCH1 - 1' 1' 1' - 7.6 7.9 7.5 - 7.7 7.9 7.7 - 82 84 73 - 9.2 6.5 4.6 - 2
GPCRdb Mean A Melanin-concentrating hormone MCHR1 MCH1 - 1' 1' 1' - 1' 1' 1' - 1' 1' 1' - 1' 1' 1' - 1' 1' 1' - 3
GPCRdb Mean A Melanin-concentrating hormone MCHR1 MCH1 - 1' 1' 1' - 1' 1' 1' - 1' 1' 1' - 1' 1' 1' - 1' 1' 1' - 4
GPCRdb Mean A Melanin-concentrating hormone MCHR2 MCH2 - - - 1' - 7.8 7.8 8.3 7.7 8.0 7.9 8.4 7.8 74 70 72 70 18.0 12.9 14.2 18.6 1
Inoue TGF A Melanin-concentrating hormone MCHR2 MCH2 melanin-concentrating hormone Physiological - - 1' - 7.8 7.8 8.3 7.7 8.0 7.9 8.4 7.8 74 70 72 70 18.0 12.9 14.2 18.6 Inoue
GPCRdb Mean A Melanin-concentrating hormone MCHR2 MCH2 - - - 1' - - - 8.3 - - - 8.4 - - - 72 - - - 14.2 - 2
GPCRdb Mean A Melanin-concentrating hormone MCHR2 MCH2 - - - 1' - - - 1' - - - 1' - - - 1' - - - 1' - 3
GPCRdb Mean A Melanin-concentrating hormone MCHR2 MCH2 - - - 1' - - - 1' - - - 1' - - - 1' - - - 1' - 4
GPCRdb Mean A Melanocortin MSHR MC1 - 1' - - - - - 7.3 - - - 8.0 - - - 17 - - - 1.2 - 1
Inoue TGF A Melanocortin MSHR MC1 α-MSH Physiological 1' - - - - - 7.3 - - - 8.0 - - - 17 - - - 1.2 - Inoue
GPCRdb Mean A Melanocortin MSHR MC1 - 1' - - - 1' - - - 1' - - - 1' - - - 1' - - - 2
GPCRdb Mean A Melanocortin MSHR MC1 - 1' - - - 1' - - - 1' - - - 1' - - - 1' - - - 3
GPCRdb Mean A Melanocortin MSHR MC1 - 1' - - - 1' - - - 1' - - - 1' - - - 1' - - - 4
GPCRdb Mean A Melanocortin ACTHR MC2 - 1' - - - - - - - - - - - - - - - - - - - 1
GPCRdb Mean A Melanocortin ACTHR MC2 - 1' - - - 1' - - - 1' - - - 1' - - - 1' - - - 2
GPCRdb Mean A Melanocortin ACTHR MC2 - 1' - - - 1' - - - 1' - - - 1' - - - 1' - - - 3
GPCRdb Mean A Melanocortin ACTHR MC2 - 1' - - - 1' - - - 1' - - - 1' - - - 1' - - - 4
GPCRdb Mean A Melanocortin MC3R MC3 - 1' - - - 8.4 7.7 9.2 7.4 9.1 8.6 9.8 8.2 48 16 34 20 3.7 5.6 51.2 8.0 1
Bouvier GEMTA A Melanocortin MC3R MC3 γ-MSH Physiological 1' - - - 9.5 7.7 10.3 6.7 9.6 8.4 10.6 7.1 89 22 55 34 6.3 10.1 101.4 15.2 Bouvier
Inoue TGF A Melanocortin MC3R MC3 α-MSH Physiological 1' - - - 7.3 7.6 8.0 8.1 8.5 8.7 9.0 9.3 7 9 12 6 1.1 1.1 1.0 0.8 Inoue
GPCRdb Mean A Melanocortin MC3R MC3 - 1' - - - 8.4 7.7 9.2 7.4 9.1 8.6 9.8 8.2 48 16 34 20 3.7 5.6 51.2 8.0 2
GPCRdb Mean A Melanocortin MC3R MC3 - 1' - - - 8.4 - - - 9.1 - - - 48 - - - 3.7 - - - 3
GPCRdb Mean A Melanocortin MC3R MC3 - 1' - - - 1' - - - 1' - - - 1' - - - 1' - - - 4
GPCRdb Mean A Melanocortin MC4R MC4 - 1' - - - 7.3 6.3 7.6 4.7 7.8 7.3 8.0 5.7 44 15 48 10 4.2 2.8 39.8 9.0 1
Bouvier GEMTA A Melanocortin MC4R MC4 α-MSH Physiological 1' - - - 7.9 6.1 8.1 4.7 8.2 7.5 8.3 5.7 55 4 64 10 4.5 1.6 76.8 9.0 Bouvier
Inoue TGF A Melanocortin MC4R MC4 α-MSH Physiological 1' - - - 6.8 6.5 7.1 - 7.3 7.1 7.6 - 34 26 31 - 3.8 4.0 2.7 - Inoue
GPCRdb Mean A Melanocortin MC4R MC4 - 1' - - - 7.3 6.3 7.6 - 7.8 7.3 8.0 - 44 15 48 - 4.2 2.8 39.8 - 2
GPCRdb Mean A Melanocortin MC4R MC4 - 1' - - - 7.3 - - - 7.8 - - - 44 - - - 4.2 - - - 3
GPCRdb Mean A Melanocortin MC4R MC4 - 1' - - - 1' - - - 1' - - - 1' - - - 1' - - - 4
GPCRdb Mean A Melanocortin MC5R MC5 - 1' - - - 5.1 5.1 5.4 5.2 6.0 5.5