Number of G protein structures

Structures Gs Gi/o Gq/11 G12/13 GPa1 Total
Non complexed G protein 32 85 12 6 - 135
Receptor - G protein complexes 382 462 133 15 1 993
Total structures 414 547 145 21 1 1128


Number of GPCR-G protein structures (distinct complexes)

Receptor Class Gs Gi/o Gq/11 G12/13 GPa1 Total
Class A 238 (51) 420 (131) 121 (52) 7 (5) - 786 (239)
Class B1 118 (15) 2 (2) 3 (2) - - 123 (19)
Class B2 14 (7) 6 (3) 4 (3) 8 (7) - 32 (20)
Class C 1 (1) 13 (7) 4 (1) - - 18 (9)
Class D1 - - - - 1 (1) 1 (1)
Class F 5 (3) 5 (1) 1 (1) - - 11 (5)
Class T2 - 16 (3) - - - 16 (3)


Specific sets of structures can be downloaded from the Structures page.
The latest released structure is from 2025-01-01.


Structural coverage of GPCR-G protein complexes.


Receptor names:


Class A
(Rhodopsin)


G Protein complexes
s i/o q/11 12/13 GPa1
Alicarboxylic acidHydroxycarboxylic acidHCAR1HCAR2HCAR3OxoglutarateOXGR1SuccinateSUCR1Aminergic5-Hydroxytryptamine5HT1A5HT1B5HT1D5HT1E5HT1F5HT2A5HT2B5HT2C5HT4R5HT5A5HT5B5HT6R5HT7RAcetylcholine (muscarinic)ACM1ACM2ACM3ACM4ACM5AdrenoceptorsADA1AADA1BADA1DADA2AADA2BADA2CADRB1ADRB2ADRB3DopamineDRD1DRD2DRD3DRD4DRD5HistamineHRH1HRH2HRH3HRH4Trace amineTAAR1LipidCannabinoidCNR1CNR2Free fatty acidFFAR1FFAR2FFAR3FFAR4GPR42GPR18, GPR55 and GPR119GPR18GPR55GP119LeukotrieneLT4R1LT4R2CLTR1CLTR2OXER1Lysophospholipid (LPA)LPAR1LPAR2LPAR3LPAR4LPAR5LPAR6Lysophospholipid (S1P)S1PR1S1PR2S1PR3S1PR4S1PR5Platelet-activating factorPTAFRProstanoidPD2RPD2R2PE2R1PE2R2PE2R3PE2R4PF2RPI2RTA2RMelatoninMelatoninMTR1AMTR1BNucleotideAdenosineAA1RAA2ARAA2BRAA3RP2YP2RY1P2RY2P2RY4P2RY6P2Y11P2Y12P2Y13P2Y14OtherUnclassifiedUS28PeptideAngiotensinAGTR1AGTR2ApelinAPJBombesinNMBRGRPRBRS3BradykininBKRB1BKRB2CholecystokininCCKARGASRComplement peptideC3ARC5AR1C5AR2EndothelinEDNRAEDNRBFormylpeptideFPR1FPR2FPR3GalaninGALR1GALR2GALR3GhrelinGHSRGonadotrophin-releasing hormoneGNRHRKisspeptinKISSRMelanin-concentrating hormoneMCHR1MCHR2MelanocortinMSHRACTHRMC3RMC4RMC5RMotilinMTLRNeuromedin UNMUR1NMUR2Neuropeptide FF/neuropeptide AFNPFF1NPFF2Neuropeptide SNPSR1Neuropeptide W/neuropeptide BNPBW1NPBW2Neuropeptide YNPY1RNPY2RNPY4RNPY5RNPY6RNeurotensinNTR1NTR2OpioidOPRDOPRKOPRMOPRXOrexinOX1ROX2RPeptide P518QRFPRProlactin-releasing peptidePRLHRProteinase-activatedPAR1PAR2PAR3PAR4Relaxin family peptideRXFP1RXFP2RL3R1RL3R2SomatostatinSSR1SSR2SSR3SSR4SSR5TachykininNK1RNK2RNK3RThyrotropin-releasing hormoneTRFRUrotensinUR2RVasopressin and oxytocinV1ARV1BRV2ROXYRProteinChemerin receptorCML1CML2ChemokineCCR1CCR2CCR3CCR4CCR5CCR6CCR7CCR8CCR9CCR10CXCR1CXCR2CXCR3CXCR4CXCR5CXCR6CX3C1XCR1ACKR1ACKR2ACKR3ACKR4CCRL2Glycoprotein hormoneFSHRLSHRTSHRProkineticinPKR1PKR2SensoryOpsinsOPSDOPN3OPN4OPN5OPSBOPSGOPSROPSXSteroidBile acidGPBAREstrogen (G protein-coupled)GPER1




Class A
Orphans

Class A orphansGPR3GPR4GPR6GPR12GPR15GPR17GPR19GPR20GPR21GPR22GPR25GPR26GPR27GPR31GPR32GPR33GPR34GPR35GPR37G37L1GPR39GPR45MTR1LGPR52GPR61GPR62GPR63PSYROGR1GPR75GPR78GPR82GPR83GPR84GPR85GPR87GPR88GP101GP132GP135GP139GP141GP142GP146GP148GP149GP150GP151GP152GP153GP160GP161GP162GP171GP173GP174GP176GP182GP183LGR4LGR5LGR6MASMAS1LMRGRDMRGREMRGRFMRGRGMRGX1MRGX2MRGX3MRGX4P2RY8P2Y10TAAR2TAAR3TAAR5TAAR6TAA7FTAAR8TAAR9TAAR4

Class B1
(Secretin)

CalcitoninCALCRCALRLCorticotropin-releasingfactorCRFR1CRFR2GlucagonreceptorfamilyGHRHRGIPRGLP1RGLP2RGLRSCTRParathyroidhormonePTH1RPTH2RVIP and PACAPPACRVIPR1VIPR2

Class B2
(Adhesion)

ADGRAAGRA1AGRA2AGRA3ADGRBAGRB1AGRB2AGRB3ADGRCCELR1CELR2CELR3ADGRDAGRD1AGRD2ADGREAGRE1AGRE2AGRE3AGRE4AGRE5ADGRFAGRF1AGRF2AGRF3AGRF4AGRF5ADGRGAGRG1AGRG2AGRG3AGRG4AGRG5AGRG6AGRG7ADGRLAGRL1AGRL2AGRL3AGRL4ADGRVAGRV1



Class C
(Glutamate)

GABA BGABR1GABR2MetabotropicglutamateGRM1GRM2GRM3GRM4GRM5GRM6GRM7GRM8Calcium-sensingCASRClass COrphansGP156GP158GP179RAI3GPC5BGPC5CGPC5DGPC6ATaste 1TS1R1TS1R2TS1R3

Class F
(Frizzled)

FrizzledFZD1FZD2FZD3FZD4FZD5FZD6FZD7FZD8FZD9FZD10SMO

Class T
(Taste 2)

Taste 2TA2R1TA2R3TA2R4TA2R5TA2R7TA2R8TA2R9T2R10T2R13T2R14T2R16T2R19T2R20T2R30T2R31T2R38T2R39T2R40T2R41T2R42T2R43T2R45T2R46T2R50T2R60