CHEMBL402143


SMILES COc1c(OCCF)cccc1C(O)C1CCN(CCc2ccc(F)cc2)CC1
InChIKey QCFZUTYIUYQTPW-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 9
Molecular weight (Da) 405.2

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
5-HT1B 5HT1B Human 5-Hydroxytryptamine A pKi 5.73 5.73 5.73 ChEMBL
5-HT1D 5HT1D Human 5-Hydroxytryptamine A pKi 6.15 6.15 6.15 ChEMBL
α1B ADA1B Human Adrenoceptors A pKi 6.49 6.49 6.49 ChEMBL
α2C ADA2C Human Adrenoceptors A pKi 6.83 6.83 6.83 ChEMBL
H2 HRH2 Human Histamine A pKi 5.5 5.5 5.5 ChEMBL
5-HT7 5HT7R Human 5-Hydroxytryptamine A pKi 6.94 6.94 6.94 ChEMBL
H1 HRH1 Human Histamine A pKi 6.43 6.43 6.43 ChEMBL
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 6.52 6.52 6.52 ChEMBL
D1 DRD1 Human Dopamine A pKi 6.05 6.05 6.05 ChEMBL
D4 DRD4 Human Dopamine A pKi 6.26 6.26 6.26 ChEMBL
5-HT6 5HT6R Human 5-Hydroxytryptamine A pKi 5.41 5.41 5.41 ChEMBL
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 7.15 7.15 7.15 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database