SCH-23390


SMILES CN1CCc2cc(Cl)c(O)cc2[C@@H](c2ccccc2)C1
InChIKey GOTMKOSCLKVOGG-OAHLLOKOSA-N

Chemical properties

Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 1
Molecular weight (Da) 287.1

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Ligand site mutations D1 D2 D5

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D1 DRD1 Mouse Dopamine A pKi 9.4 9.4 9.4 ChEMBL
D1 DRD1 Goldfish Dopamine A pKi 8.89 8.89 8.89 ChEMBL
D2 DRD2 Mouse Dopamine A pKi 5.92 5.92 5.92 ChEMBL
D1 DRD1 Pig Dopamine A pKi 9.3 9.3 9.3 ChEMBL
D1 DRD1 Bovine Dopamine A pKi 7.43 8.75 10.0 ChEMBL
D3 DRD3 Rat Dopamine A pKi 6.12 6.12 6.12 ChEMBL
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 7.9 7.9 7.9 ChEMBL
D5 DRD5 Human Dopamine A pKi 8.09 9.05 9.77 ChEMBL
D1 DRD1 Rat Dopamine A pKi 6.17 9.19 9.92 ChEMBL
D1 DRD1 Human Dopamine A pKi 7.62 9.38 10.0 ChEMBL
D1 DRD1 Human Dopamine A pKd 9.42 9.42 9.42 ChEMBL
D2 DRD2 Rat Dopamine A pKi 6.05 6.52 9.27 ChEMBL
D2 DRD2 Human Dopamine A pKi 6.0 6.03 6.05 ChEMBL
5-HT2C K7GSR7 Pig 5-Hydroxytryptamine A pKi 5.27 7.86 8.3 PDSP Ki database
5-HT1A 5HT1A Rat 5-Hydroxytryptamine A pKi 6.58 6.58 6.58 PDSP Ki database
5-HT1A A0A4X1UTF5 Pig 5-Hydroxytryptamine A pKi 6.47 6.47 6.47 PDSP Ki database
5-HT1B 5HT1B Rat 5-Hydroxytryptamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT1D F1MMU1 Bovine 5-Hydroxytryptamine A pKi 5.4 5.43 5.5 PDSP Ki database
5-HT2C 5HT2C Rat 5-Hydroxytryptamine A pKi 7.87 7.87 7.87 PDSP Ki database
5-HT6 5HT6R Mouse 5-Hydroxytryptamine A pKi 5.6 5.6 5.6 PDSP Ki database
D1 DRD1 Bovine Dopamine A pKi 5.0 7.12 9.24 PDSP Ki database
D2 DRD2 Rat Dopamine A pKi 5.25 5.72 6.44 PDSP Ki database
D5 DRD5 Rat Dopamine A pKi 9.0 9.16 9.33 PDSP Ki database
D1 DRD1 Rat Dopamine A pKi 6.75 9.3 9.92 PDSP Ki database
5-HT2B 5HT2B Rat 5-Hydroxytryptamine A pKi 7.08 7.08 7.08 PDSP Ki database
D1 DRD1 Human Dopamine A pKi 9.46 9.46 9.46 PDSP Ki database
D5 DRD5 Human Dopamine A pKi 9.52 9.52 9.52 PDSP Ki database
D2 DRD2 Human Dopamine A pKi 5.67 5.86 6.04 PDSP Ki database
D4 DRD4 Human Dopamine A pKi 5.45 5.45 5.45 PDSP Ki database
D2 DRD2 Mouse Dopamine A pKi 6.05 6.05 6.05 PDSP Ki database
D1 DRD1 Mouse Dopamine A pKi 9.85 9.85 9.85 PDSP Ki database
D1 DRD1 Rhesus macaque Dopamine A pKi 8.89 9.05 9.22 PDSP Ki database
D3 DRD3 Human Dopamine A pKi 5.0 5.0 5.0 PDSP Ki database
5-HT2A 5HT2A Human 5-Hydroxytryptamine A pKi 7.88 7.88 7.88 PDSP Ki database
5-HT2B 5HT2B Human 5-Hydroxytryptamine A pKi 7.15 7.15 7.15 PDSP Ki database
5-HT2C 5HT2C Human 5-Hydroxytryptamine A pKi 7.39 7.39 7.39 PDSP Ki database
H1 HRH1 Human Histamine A pKi 7.0 7.0 7.0 PDSP Ki database
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D5 DRD5 Human Dopamine A pIC50 8.96 9.4 9.82 ChEMBL
D1 DRD1 Rat Dopamine A pIC50 8.37 8.9 9.24 ChEMBL
D1 DRD1 Human Dopamine A pIC50 6.28 8.57 9.66 ChEMBL
D2 DRD2 Rat Dopamine A pIC50 5.72 5.97 6.22 ChEMBL
D2 DRD2 Human Dopamine A pIC50 5.69 6.93 7.59 ChEMBL
TSH TSHR Human Glycoprotein hormone A Potency 4.6 4.6 4.6 ChEMBL