CHEMBL262724


SMILES O=C(NCCCCN1CCN(c2cccc(Cl)c2Cl)CC1)c1cnc2ccccc2n1
InChIKey WKAAYYBBGYEZQQ-UHFFFAOYSA-N

Chemical properties

Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 7
Molecular weight (Da) 457.1

Drug properties

Molecular type Small molecule
Endogenous/Surrogate Surrogate
Approved drug No

Database connections

Bioactivities

Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D3 DRD3 Rat Dopamine A pKi 8.72 8.72 8.72 ChEMBL
D2 DRD2 Rat Dopamine A pKi 6.96 6.96 6.96 ChEMBL
D3 DRD3 Human Dopamine A pKi 7.97 8.56 8.85 ChEMBL
D2 DRD2 Human Dopamine A pKi 7.23 7.43 7.53 ChEMBL
Receptor Activity Source
GTP Uniprot Species Family Class Type Min Avg Max Database
D3 DRD3 Human Dopamine A pIC50 7.57 7.57 7.57 ChEMBL
D2 DRD2 Human Dopamine A pIC50 7.12 7.12 7.12 ChEMBL