Adapted from Pándy-Szekeres et al., Nucleic Acids Research, 2023
New G protein couplings
Unified coupling atlas and G protein selectivity profiles.
GPCR - G protein structure interface
Structure based coupling interface interactions for structures and models.
Structure models
New GPCR-G protein structure models with AlphaFold2-Multimer.
Sequence alignments
Alignments with generic residue numbers and residue plots.
Structures
G protein structure statistics and browser with unique annotation.
GproteinDb
GproteinDb (G protein database) offers:
- Reference data (see Data box)
- Analysis tools (browse menu)
- Visualization (e.g., snakeplots)
- Experiment design (Coupling determinant mutations)
- Data deposition (for G protein couplings and interface mutations)
G proteins are the main mediators of GPCR signaling1.
Their activation is followed by recruitment of arrestins that arrest (stop) signaling or scaffold additional signaling proteins.
There are 16 human G protein subtypes from 4 families that can be involved in biased signaling.
Data
- Sequences
- 16 Human G proteins
- 317 Species orthologs
- Couplings
- 3,052 G protein couplings
- Structures
- 1,086 G proteins
- 970 G protein complexes
- 539 Generic residues
- Structure models
- 5,595 G protein complexes
- 357 Refined complexes
- Structure interactions
- 376,338 G protein interface
- Mutations
- 54 Interface mutations
Overview
Related resources
GPCRdb, GproteinDb, ArrestinDb and Biased Signaling Atlas cover related aspects of signal transduction while serving dedicated research communities and use cases.Publications
GproteinDb in 2024: New G protein-GPCR couplings, AlphaFold2-Multimer models and interface interactions.
Pándy-Szekeres G, Taracena Herrera LP, Caroli J, Kermani AA, Kulkarni Y, Keserű GM, Gloriam DE
Nucleic Acids Research, 2023
The G protein database, GproteinDb.
Pándy-Szekeres G, Esguerra M, Hauser AS, Caroli J, Munk C, Pilger S, Keserű GM, Kooistra AJ, Gloriam DE
Nucleic Acids Research, 2021
