Adapted from Pándy-Szekeres et al., Nucleic Acids Research, 2023
New G protein couplings
Unified coupling atlas and G protein selectivity profiles.
GPCR - G protein structure interface
Structure based coupling interface interactions for structures and models.
Structure models
New GPCR-G protein structure models with AlphaFold2-Multimer.
Sequence alignments
Alignments with generic residue numbers and residue plots.
Structures
G protein structure statistics and browser with unique annotation.
GproteinDb
GproteinDb (G protein database) offers:
- Reference data (see Data box)
- Analysis tools (browse menu)
- Visualization (e.g., snakeplots)
- Experiment design (Coupling determinant mutations)
- Data deposition (for G protein couplings and interface mutations)
G proteins are the main mediators of GPCR signaling1.
Their activation is followed by recruitment of arrestins that arrest (stop) signaling or scaffold additional signaling proteins.
There are 16 human G protein subtypes from 4 families that can be involved in biased signaling.
Data
- Sequences
- 16 Human G proteins
- 317 Species orthologs
- Couplings
- 3,052 G protein couplings
- Structures
- 815 G proteins
- 697 G protein complexes
- 539 Generic residues
- Structure models
- 5,592 G protein complexes
- 239 Refined complexes
- Structure interactions
- 360,784 G protein interface
- Mutations
- 54 Interface mutations
Overview
Latest release
Nov. 6, 2024- New
- Odorant receptors (human + model organisms)
- Data Mapper (map own data onto GPCR plots)
- Physiological ligand-GPCR complex models (AF2-Multimer and RoseTTAFold)
- Structure Similarity Search (Foldseek)
- Updated
- Ligand search tool (by name, database ID, structure)
- Inactive-/active-state GPCR models (AF2 and AF2-Multistate)
- Minor bug and performance fixes
All releases
Related resources
GPCRdb, GproteinDb, ArrestinDb and Biased Signaling Atlas cover related aspects of signal transduction while serving dedicated research communities and use cases.Publications
GproteinDb in 2024: New G protein-GPCR couplings, AlphaFold2-Multimer models and interface interactions.
Pándy-Szekeres G, Taracena Herrera LP, Caroli J, Kermani AA, Kulkarni Y, Keserű GM, Gloriam DE
Nucleic Acids Research, 2023
The G protein database, GproteinDb.
Pándy-Szekeres G, Esguerra M, Hauser AS, Caroli J, Munk C, Pilger S, Keserű GM, Kooistra AJ, Gloriam DE
Nucleic Acids Research, 2021
