ccr2_human
NAME
6GPS
ORGANISM
Human (Homo sapiens)
PROTEIN NAME
ccr2_human
SOURCE
SWISSPROT
SEQUENCE
Perspective:
Wild-type
Construct
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N-term | |||||||||
M
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L
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S
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T
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S
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R
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S
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R
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F
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I
|
10 |
R
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N
|
T
|
N
|
E
|
S
|
G
|
E
|
E
|
V
|
20 |
T
|
T
|
F
|
F
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D
|
Y
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D
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Y
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G
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A
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30 |
TM1 | |||||||||
P
|
C
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H
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K
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F
|
D
|
V
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K
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Q
|
I
|
40 |
G
|
A
|
Q
|
L
|
L
|
P
|
P
|
L
|
Y
|
S
|
50 |
L
|
V
|
F
|
I
|
F
|
G
|
F
|
V
|
G
|
N
|
60 |
M
|
L
|
V
|
V
|
L
|
I
|
L
|
I
|
N
|
C
|
70 |
ICL1 | TM2 | ||||||||
K
|
K
|
L
|
K
|
C
|
L
|
T
|
D
|
I
|
Y
|
80 |
L
|
L
|
N
|
L
|
A
|
I
|
S
|
D
|
L
|
L
|
90 |
F
|
L
|
I
|
T
|
L
|
P
|
L
|
W
|
A
|
H
|
100 |
ECL1 | |||||||||
S
|
A
|
A
|
N
|
E
|
W
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V
|
F
|
G
|
N
|
110 |
TM3 | |||||||||
A
|
M
|
C
|
K
|
L
|
F
|
T
|
G
|
L
|
Y
|
120 |
H
|
I
|
G
|
Y
|
F
|
G
|
G
|
I
|
F
|
F
|
130 |
I
|
I
|
L
|
L
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T
|
I
|
D
|
R
|
Y
|
L
|
140 |
ICL2 | |||||||||
A
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I
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V
|
H
|
A
|
V
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F
|
A
|
L
|
K
|
150 |
TM4 | |||||||||
A
|
R
|
T
|
V
|
T
|
F
|
G
|
V
|
V
|
T
|
160 |
S
|
V
|
I
|
T
|
W
|
L
|
V
|
A
|
V
|
F
|
170 |
A
|
S
|
V
|
P
|
G
|
I
|
I
|
F
|
T
|
K
|
180 |
ECL2 | |||||||||
C
|
Q
|
K
|
E
|
D
|
S
|
V
|
Y
|
V
|
C
|
190 |
TM5 | |||||||||
G
|
P
|
Y
|
F
|
P
|
R
|
G
|
W
|
N
|
N
|
200 |
F
|
H
|
T
|
I
|
M
|
R
|
N
|
I
|
L
|
G
|
210 |
L
|
V
|
L
|
P
|
L
|
L
|
I
|
M
|
V
|
I
|
220 |
C
|
Y
|
S
|
G
|
I
|
L
|
K
|
T
|
L
|
L
|
230 |
|
|
|
|||||||
ICL3 | TM6 | ||||||||
R
|
C
|
R
|
N
|
E
|
K
|
K
|
R
|
H
|
R
|
240 |
A
|
V
|
R
|
V
|
I
|
F
|
T
|
I
|
M
|
I
|
250 |
V
|
Y
|
F
|
L
|
F
|
W
|
T
|
P
|
Y
|
N
|
260 |
I
|
V
|
I
|
L
|
L
|
N
|
T
|
F
|
Q
|
E
|
270 |
ECL3 | TM7 | ||||||||
F
|
F
|
G
|
L
|
S
|
N
|
C
|
E
|
S
|
T
|
280 |
S
|
Q
|
L
|
D
|
Q
|
A
|
T
|
Q
|
V
|
T
|
290 |
E
|
T
|
L
|
G
|
M
|
T
|
H
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C
|
C
|
I
|
300 |
H8 | |||||||||
N
|
P
|
I
|
I
|
Y
|
A
|
F
|
V
|
G
|
E
|
310 |
K
|
F
|
R
|
S
|
L
|
F
|
H
|
I
|
A
|
L
|
320 |
C-term | |||||||||
G
|
C
|
R
|
I
|
A
|
P
|
L
|
Q
|
K
|
P
|
330 |
V
|
C
|
G
|
G
|
P
|
G
|
V
|
R
|
P
|
G
|
340 |
K
|
N
|
V
|
K
|
V
|
T
|
T
|
Q
|
G
|
L
|
350 |
L
|
D
|
G
|
R
|
G
|
K
|
G
|
K
|
S
|
I
|
360 |
G
|
R
|
A
|
P
|
E
|
A
|
S
|
L
|
Q
|
D
|
370 |
K
|
E
|
G
|
A
|
|
|||||||||
N-term | |||||||||
|
L
|
S
|
T
|
S
|
R
|
S
|
R
|
F
|
I
|
10 |
R
|
N
|
T
|
N
|
E
|
S
|
G
|
E
|
E
|
V
|
20 |
T
|
T
|
F
|
F
|
D
|
Y
|
D
|
Y
|
G
|
A
|
30 |
TM1 | |||||||||
P
|
C
|
H
|
K
|
F
|
D
|
V
|
K
|
Q
|
I
|
40 |
G
|
A
|
Q
|
L
|
L
|
P
|
P
|
L
|
Y
|
S
|
50 |
L
|
V
|
F
|
I
|
F
|
G
|
F
|
V
|
G
|
N
|
60 |
M
|
L
|
V
|
V
|
L
|
I
|
L
|
I
|
N
|
C
|
70 |
ICL1 | TM2 | ||||||||
K
|
K
|
L
|
K
|
C
|
L
|
T
|
D
|
I
|
Y
|
80 |
L
|
L
|
N
|
L
|
A
|
I
|
S
|
D
|
L
|
L
|
90 |
F
|
L
|
I
|
T
|
L
|
P
|
L
|
W
|
A
|
H
|
100 |
ECL1 | |||||||||
S
|
A
|
A
|
N
|
E
|
W
|
V
|
F
|
G
|
N
|
110 |
TM3 | |||||||||
A
|
M
|
C
|
K
|
L
|
F
|
T
|
G
|
L
|
Y
|
120 |
H
|
I
|
G
|
Y
|
F
|
G
|
G
|
I
|
F
|
F
|
130 |
I
|
I
|
L
|
L
|
T
|
I
|
D
|
R
|
Y
|
L
|
140 |
ICL2 | |||||||||
A
|
I
|
V
|
H
|
A
|
V
|
F
|
A
|
L
|
K
|
150 |
TM4 | |||||||||
A
|
R
|
T
|
V
|
T
|
F
|
G
|
V
|
V
|
T
|
160 |
S
|
V
|
I
|
T
|
W
|
L
|
V
|
A
|
V
|
F
|
170 |
A
|
S
|
V
|
P
|
G
|
I
|
I
|
F
|
T
|
K
|
180 |
ECL2 | |||||||||
C
|
Q
|
K
|
E
|
D
|
S
|
V
|
Y
|
V
|
C
|
190 |
TM5 | |||||||||
G
|
P
|
Y
|
F
|
P
|
R
|
G
|
W
|
N
|
N
|
200 |
F
|
H
|
T
|
I
|
M
|
R
|
N
|
I
|
L
|
G
|
210 |
L
|
V
|
L
|
P
|
L
|
L
|
I
|
M
|
V
|
I
|
220 |
C
|
Y
|
S
|
G
|
I
|
L
|
K
|
T
|
L
|
L
|
230 |
|
|
R
|
|
|
|
|
|
|
|
|
|
|
|
Rubredoxin | |||||||||
|
|
|
|
|
|
|
|
|
|
TM6 | |||||||
E
|
K
|
K
|
R
|
H
|
R
|
A
|
V
|
242 |
R
|
V
|
I
|
F
|
T
|
I
|
M
|
I
|
V
|
Y
|
252 |
F
|
L
|
F
|
W
|
T
|
P
|
Y
|
N
|
I
|
V
|
262 |
I
|
L
|
L
|
N
|
T
|
F
|
Q
|
E
|
F
|
F
|
272 |
ECL3 | TM7 | ||||||||
G
|
L
|
S
|
N
|
C
|
E
|
S
|
T
|
S
|
Q
|
282 |
L
|
D
|
Q
|
A
|
T
|
Q
|
V
|
T
|
E
|
T
|
292 |
L
|
G
|
M
|
T
|
H
|
C
|
C
|
I
|
N
|
P
|
302 |
H8 | |||||||||
I
|
I
|
Y
|
A
|
F
|
V
|
G
|
E
|
K
|
F
|
312 |
R
|
S
|
L
|
F
|
H
|
I
|
A
|
L
|
G
|
C
|
322 |
C-term | |||||||||
R
|
I
|
A
|
P
|
L
|
Q
|
K
|
P
|
V
|
C
|
332 |
G
|
G
|
P
|
G
|
V
|
R
|
P
|
G
|
K
|
N
|
342 |
V
|
K
|
V
|
T
|
T
|
Q
|
G
|
L
|
L
|
D
|
352 |
G
|
R
|
G
|
K
|
G
|
K
|
S
|
I
|
G
|
R
|
362 |
A
|
P
|
E
|
A
|
S
|
L
|
Q
|
D
|
K
|
E
|
372 |
G
|
A
|
374 |
|
|
|
|
|
|
|
|
|
|
|
Expression | ||||||||||
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|
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SCHEMATIC
Perspective:
Wild-type
Construct
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DIAGRAMS
MUTATIONS
Position | Wild-type | Mutated |
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DELETIONS
MODIFICATIONS
AUXILIARY PROTEINS
Protein_type: auto
Name: Expression tag
Sequence: None
Deletions:
Positions: C-term_1 None:None
Presence in Crystal:YES
Remarks: None
Protein_type: fusion
Name: Rubredoxin
Sequence: None
Deletions:
Positions: Within Receptor_0 232:232
Presence in Crystal:YES
Remarks: None
EXPRESSION
Expression method | Host cell type | Host cell | Remarks |
---|---|---|---|
SOLUBILIZATION
Solvent type | Item | Concentration |
---|
Remarks:
PURIFICATION
Purification type | Description |
---|
Remarks:
CRYSTALLIZATION
METHOD:
TYPE: ()
PROTEIN CONCENTRATION:
Temperature:
ph : -
Remarks:
Chemical lists
Type | Item | Concentration |
---|