Click a Venn or table area to retrieve the receptors with the given G protein family profile.
| Class (Family) |
A (Rhodopsin) | B1 (Secretin) | B2 (Adhesion) | C (Glutamate) | F (Frizzled) | T2 (Taste 2) | Total |
| Gs | 66 | 11 | 1 | 2 | 2 | 0 | 82 |
| Gi/o | 153 | 7 | 1 | 9 | 6 | 0 | 176 |
| Gq/11 | 122 | 7 | 4 | 4 | 2 | 0 | 139 |
| G12/13 | 35 | 2 | 2 | 1 | 3 | 0 | 43 |
| Total (unique) | 214 | 12 | 7 | 10 | 9 | 0 | 252 |
| Class | Ligand type | Receptor Family | Receptor (UniProt) |
Receptor (Gene) |
Receptor (GtP) |
|---|---|---|---|---|---|
References
We used the G protein transducer information from the Guide to Pharmacology database (IUPHAR) and the following datasets:
The IUPHAR/BPS Guide to PHARMACOLOGY in 2020: extending immunopharmacology content and introducing the IUPHAR/MMV Guide to MALARIA PHARMACOLOGY.
Armstrong, J. F., Faccenda, E., Harding, S. D., Pawson, A. J., Southan, C., Sharman, J. L., Campo, B., Cavanagh, D. R., Alexander, S. P. H., Davenport, A. P., Spedding, M., Davies, J. A. & NC-IUPHAR.
Nucleic Acids Res 48, D1006–D1021 (2020). [PMID:31691834]
Illuminating G-Protein-Coupling Selectivity of GPCRs.
Inoue, A., Raimondi, F., Kadji, F. M. N., Singh, G., Kishi, T., Uwamizu, A., Ono, Y., Shinjo, Y., Ishida, S., Arang, N., Kawakami, K., Gutkind, J. S., Aoki, J. & Russell, R. B.
Cell 177, 1933-1947.e25 (2019). [PMID:31160049]
Effector membrane translocation biosensors reveal G protein and βarrestin coupling profiles of 100 therapeutically relevant GPCRs.
Avet, C., Mancini, A., Breton, B., Le Gouill, C., Hauser, A.S., Normand, C., Kobayashi, H., Gross, F., Hogue, M., Lukasheva, V., St-Onge, S., Carrier, M., Héroux, M., Morissette, S., Fauman, E.B., Fortin, J.P., Schann, S., Leroy, X., Gloriam, D.E., Bouvier, M.
eLife. 2022 doi: 10.7554/eLife.74101