fzd1_human
NAME
8J9N
ORGANISM
Human (Homo sapiens)
PROTEIN NAME
fzd1_human
SOURCE
SWISSPROT
SEQUENCE
Perspective:
Wild-type
Construct
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N-term | |||||||||
M
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A
|
E
|
E
|
E
|
A
|
P
|
K
|
K
|
S
|
10 |
|
|
|
|
|
|
|
|
|
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R
|
A
|
A
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G
|
G
|
G
|
A
|
S
|
W
|
E
|
20 |
|
|
|
|
|
|
|
|
|
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L
|
C
|
A
|
G
|
A
|
L
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S
|
A
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R
|
L
|
30 |
|
|
|
|
|
|
|
|
|
|
A
|
E
|
E
|
G
|
S
|
G
|
D
|
A
|
G
|
G
|
40 |
|
|
|
|
|
|
|
|
|
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R
|
R
|
R
|
P
|
P
|
V
|
D
|
P
|
R
|
R
|
50 |
|
|
|
|
|
|
|
|
|
|
L
|
A
|
R
|
Q
|
L
|
L
|
L
|
L
|
L
|
W
|
60 |
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||
L
|
L
|
E
|
A
|
P
|
L
|
L
|
L
|
G
|
V
|
70 |
R
|
A
|
Q
|
A
|
A
|
G
|
Q
|
G
|
P
|
G
|
80 |
Q
|
G
|
P
|
G
|
P
|
G
|
Q
|
Q
|
P
|
P
|
90 |
P
|
P
|
P
|
Q
|
Q
|
Q
|
Q
|
S
|
G
|
Q
|
100 |
Q
|
Y
|
N
|
G
|
E
|
R
|
G
|
I
|
S
|
V
|
110 |
P
|
D
|
H
|
G
|
Y
|
C
|
Q
|
P
|
I
|
S
|
120 |
I
|
P
|
L
|
C
|
T
|
D
|
I
|
A
|
Y
|
N
|
130 |
Q
|
T
|
I
|
M
|
P
|
N
|
L
|
L
|
G
|
H
|
140 |
T
|
N
|
Q
|
E
|
D
|
A
|
G
|
L
|
E
|
V
|
150 |
H
|
Q
|
F
|
Y
|
P
|
L
|
V
|
K
|
V
|
Q
|
160 |
C
|
S
|
A
|
E
|
L
|
K
|
F
|
F
|
L
|
C
|
170 |
S
|
M
|
Y
|
A
|
P
|
V
|
C
|
T
|
V
|
L
|
180 |
E
|
Q
|
A
|
L
|
P
|
P
|
C
|
R
|
S
|
L
|
190 |
C
|
E
|
R
|
A
|
R
|
Q
|
G
|
C
|
E
|
A
|
200 |
L
|
M
|
N
|
K
|
F
|
G
|
F
|
Q
|
W
|
P
|
210 |
D
|
T
|
L
|
K
|
C
|
E
|
K
|
F
|
P
|
V
|
220 |
H
|
G
|
A
|
G
|
E
|
L
|
C
|
V
|
G
|
Q
|
230 |
N
|
T
|
S
|
D
|
K
|
G
|
T
|
P
|
T
|
P
|
240 |
S
|
L
|
L
|
P
|
E
|
F
|
W
|
T
|
S
|
N
|
250 |
P
|
Q
|
H
|
G
|
G
|
G
|
G
|
H
|
R
|
G
|
260 |
G
|
F
|
P
|
G
|
G
|
A
|
G
|
A
|
S
|
E
|
270 |
R
|
G
|
K
|
F
|
S
|
C
|
P
|
R
|
A
|
L
|
280 |
K
|
V
|
P
|
S
|
Y
|
L
|
N
|
Y
|
H
|
F
|
290 |
L
|
G
|
E
|
K
|
D
|
C
|
G
|
A
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P
|
C
|
300 |
E
|
P
|
T
|
K
|
V
|
Y
|
G
|
L
|
M
|
Y
|
310 |
TM1 | |||||||||
F
|
G
|
P
|
E
|
E
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L
|
R
|
F
|
S
|
R
|
320 |
T
|
W
|
I
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G
|
I
|
W
|
S
|
V
|
L
|
C
|
330 |
C
|
A
|
S
|
T
|
L
|
F
|
T
|
V
|
L
|
T
|
340 |
ICL1 | |||||||||
Y
|
L
|
V
|
D
|
M
|
R
|
R
|
F
|
S
|
Y
|
350 |
TM2 | |||||||||
P
|
E
|
R
|
P
|
I
|
I
|
F
|
L
|
S
|
G
|
360 |
C
|
Y
|
T
|
A
|
V
|
A
|
V
|
A
|
Y
|
I
|
370 |
ECL1 | |||||||||
A
|
G
|
F
|
L
|
L
|
E
|
D
|
R
|
V
|
V
|
380 |
C
|
N
|
D
|
K
|
F
|
A
|
E
|
D
|
G
|
A
|
390 |
R
|
T
|
V
|
A
|
Q
|
G
|
T
|
K
|
K
|
E
|
400 |
TM3 | |||||||||
G
|
C
|
T
|
I
|
L
|
F
|
M
|
M
|
L
|
Y
|
410 |
F
|
F
|
S
|
M
|
A
|
S
|
S
|
I
|
W
|
W
|
420 |
V
|
I
|
L
|
S
|
L
|
T
|
W
|
F
|
L
|
A
|
430 |
ICL2 | TM4 | ||||||||
A
|
G
|
M
|
K
|
W
|
G
|
H
|
E
|
A
|
I
|
440 |
E
|
A
|
N
|
S
|
Q
|
Y
|
F
|
H
|
L
|
A
|
450 |
A
|
W
|
A
|
V
|
P
|
A
|
I
|
K
|
T
|
I
|
460 |
ECL2 | |||||||||
T
|
I
|
L
|
A
|
L
|
G
|
Q
|
V
|
D
|
G
|
470 |
D
|
V
|
L
|
S
|
G
|
V
|
C
|
F
|
V
|
G
|
480 |
TM5 | |||||||||
L
|
N
|
N
|
V
|
D
|
A
|
L
|
R
|
G
|
F
|
490 |
V
|
L
|
A
|
P
|
L
|
F
|
V
|
Y
|
L
|
F
|
500 |
I
|
G
|
T
|
S
|
F
|
L
|
L
|
A
|
G
|
F
|
510 |
V
|
S
|
L
|
F
|
R
|
I
|
R
|
T
|
I
|
M
|
520 |
ICL3 | TM6 | |||||||||
K
|
H
|
D
|
G
|
T
|
K
|
T
|
E
|
K
|
L
|
|
530 |
E
|
K
|
L
|
M
|
V
|
R
|
I
|
G
|
V
|
F
|
540 |
S
|
V
|
L
|
Y
|
T
|
V
|
P
|
A
|
T
|
I
|
550 |
V
|
I
|
A
|
C
|
Y
|
F
|
Y
|
E
|
Q
|
A
|
560 |
F
|
R
|
D
|
Q
|
W
|
E
|
R
|
S
|
W
|
V
|
570 |
ECL3 | |||||||||
A
|
Q
|
S
|
C
|
K
|
S
|
Y
|
A
|
I
|
P
|
580 |
C
|
P
|
H
|
L
|
Q
|
A
|
G
|
G
|
G
|
A
|
590 |
P
|
P
|
H
|
P
|
P
|
M
|
S
|
P
|
D
|
F
|
600 |
TM7 | |||||||||
T
|
V
|
F
|
M
|
I
|
K
|
Y
|
L
|
M
|
T
|
610 |
L
|
I
|
V
|
G
|
I
|
T
|
S
|
G
|
F
|
W
|
620 |
H8 | |||||||||
I
|
W
|
S
|
G
|
K
|
T
|
L
|
N
|
S
|
W
|
630 |
R
|
K
|
F
|
Y
|
T
|
R
|
L
|
T
|
N
|
S
|
640 |
C-term | ||||||
K
|
Q
|
G
|
E
|
T
|
T
|
V
|
|
|||||||||
N-term | |||||||||
|
G
|
V
|
R
|
A
|
Q
|
A
|
A
|
G
|
Q
|
77 |
G
|
P
|
G
|
Q
|
G
|
P
|
G
|
P
|
G
|
Q
|
87 |
Q
|
P
|
P
|
P
|
P
|
P
|
Q
|
Q
|
Q
|
Q
|
97 |
S
|
G
|
Q
|
Q
|
Y
|
N
|
G
|
E
|
R
|
G
|
107 |
I
|
S
|
V
|
P
|
D
|
H
|
G
|
Y
|
C
|
Q
|
117 |
P
|
I
|
S
|
I
|
P
|
L
|
C
|
T
|
D
|
I
|
127 |
A
|
Y
|
N
|
Q
|
T
|
I
|
M
|
P
|
N
|
L
|
137 |
L
|
G
|
H
|
T
|
N
|
Q
|
E
|
D
|
A
|
G
|
147 |
L
|
E
|
V
|
H
|
Q
|
F
|
Y
|
P
|
L
|
V
|
157 |
K
|
V
|
Q
|
C
|
S
|
A
|
E
|
L
|
K
|
F
|
167 |
F
|
L
|
C
|
S
|
M
|
Y
|
A
|
P
|
V
|
C
|
177 |
T
|
V
|
L
|
E
|
Q
|
A
|
L
|
P
|
P
|
C
|
187 |
R
|
S
|
L
|
C
|
E
|
R
|
A
|
R
|
Q
|
G
|
197 |
C
|
E
|
A
|
L
|
M
|
N
|
K
|
F
|
G
|
F
|
207 |
Q
|
W
|
P
|
D
|
T
|
L
|
K
|
C
|
E
|
K
|
217 |
F
|
P
|
V
|
H
|
G
|
A
|
G
|
E
|
L
|
C
|
227 |
V
|
G
|
Q
|
N
|
T
|
S
|
D
|
K
|
G
|
T
|
237 |
P
|
T
|
P
|
S
|
L
|
L
|
P
|
E
|
F
|
W
|
247 |
T
|
S
|
N
|
P
|
Q
|
H
|
G
|
G
|
G
|
G
|
257 |
H
|
R
|
G
|
G
|
F
|
P
|
G
|
G
|
A
|
G
|
267 |
A
|
S
|
E
|
R
|
G
|
K
|
F
|
S
|
C
|
P
|
277 |
R
|
A
|
L
|
K
|
V
|
P
|
S
|
Y
|
L
|
N
|
287 |
Y
|
H
|
F
|
L
|
G
|
E
|
K
|
D
|
C
|
G
|
297 |
A
|
P
|
C
|
E
|
P
|
T
|
K
|
V
|
Y
|
G
|
307 |
TM1 | |||||||||
L
|
M
|
Y
|
F
|
G
|
P
|
E
|
E
|
L
|
R
|
317 |
F
|
S
|
R
|
T
|
W
|
I
|
G
|
I
|
W
|
S
|
327 |
V
|
L
|
C
|
C
|
A
|
S
|
T
|
L
|
F
|
T
|
337 |
V
|
L
|
T
|
Y
|
L
|
V
|
D
|
M
|
R
|
R
|
347 |
ICL1 | TM2 | ||||||||
F
|
S
|
Y
|
P
|
E
|
R
|
P
|
I
|
I
|
F
|
357 |
L
|
S
|
G
|
C
|
Y
|
T
|
A
|
V
|
A
|
V
|
367 |
A
|
Y
|
I
|
A
|
G
|
F
|
L
|
L
|
E
|
D
|
377 |
ECL1 | |||||||||
R
|
V
|
V
|
C
|
N
|
D
|
K
|
F
|
A
|
E
|
387 |
D
|
G
|
A
|
R
|
T
|
V
|
A
|
Q
|
G
|
T
|
397 |
TM3 | |||||||||
K
|
K
|
E
|
G
|
C
|
T
|
I
|
L
|
F
|
M
|
407 |
M
|
L
|
Y
|
F
|
F
|
S
|
M
|
A
|
S
|
S
|
417 |
I
|
W
|
W
|
V
|
I
|
L
|
S
|
L
|
T
|
W
|
427 |
ICL2 | |||||||||
F
|
L
|
A
|
A
|
G
|
M
|
K
|
W
|
G
|
H
|
437 |
TM4 | |||||||||
E
|
A
|
I
|
E
|
A
|
N
|
S
|
Q
|
Y
|
F
|
447 |
H
|
L
|
A
|
A
|
W
|
A
|
V
|
P
|
A
|
I
|
457 |
K
|
T
|
I
|
T
|
I
|
L
|
A
|
L
|
G
|
Q
|
467 |
ECL2 | |||||||||
V
|
D
|
G
|
D
|
V
|
L
|
S
|
G
|
V
|
C
|
477 |
TM5 | |||||||||
F
|
V
|
G
|
L
|
N
|
N
|
V
|
D
|
A
|
L
|
487 |
R
|
G
|
F
|
V
|
L
|
A
|
P
|
L
|
F
|
V
|
497 |
Y
|
L
|
F
|
I
|
G
|
T
|
S
|
F
|
L
|
L
|
507 |
A
|
G
|
F
|
V
|
S
|
L
|
F
|
R
|
I
|
R
|
517 |
T
|
I
|
M
|
K
|
H
|
D
|
G
|
T
|
K
|
T
|
527 |
TM6 | |||||||||
E
|
K
|
L
|
E
|
K
|
L
|
M
|
V
|
R
|
I
|
537 |
G
|
V
|
F
|
S
|
V
|
L
|
Y
|
T
|
V
|
P
|
547 |
A
|
T
|
I
|
V
|
I
|
A
|
C
|
Y
|
F
|
Y
|
557 |
E
|
Q
|
A
|
F
|
R
|
D
|
Q
|
W
|
E
|
R
|
567 |
ECL3 | |||||||||
S
|
W
|
V
|
A
|
Q
|
S
|
C
|
K
|
S
|
Y
|
577 |
A
|
I
|
P
|
C
|
P
|
H
|
L
|
Q
|
A
|
G
|
587 |
G
|
G
|
A
|
P
|
P
|
H
|
P
|
P
|
M
|
S
|
597 |
TM7 | |||||||||
P
|
D
|
F
|
T
|
V
|
F
|
M
|
I
|
K
|
Y
|
607 |
L
|
M
|
T
|
L
|
I
|
V
|
G
|
I
|
T
|
S
|
617 |
H8 | |||||||||
G
|
F
|
W
|
I
|
W
|
S
|
G
|
K
|
T
|
L
|
627 |
N
|
S
|
W
|
R
|
K
|
F
|
Y
|
T
|
R
|
L
|
637 |
C-term | |||||||||
T
|
N
|
S
|
K
|
Q
|
G
|
E
|
T
|
T
|
V
|
647 |
SCHEMATIC
Perspective:
Wild-type
Construct
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
DIAGRAMS
MUTATIONS
Position | Wild-type | Mutated |
---|
DELETIONS
MODIFICATIONS
AUXILIARY PROTEINS
EXPRESSION
Expression method | Host cell type | Host cell | Remarks |
---|---|---|---|
SOLUBILIZATION
Solvent type | Item | Concentration |
---|
Remarks:
PURIFICATION
Purification type | Description |
---|
Remarks:
CRYSTALLIZATION
METHOD:
TYPE: ()
PROTEIN CONCENTRATION:
Temperature:
ph : -
Remarks:
Chemical lists
Type | Item | Concentration |
---|