5ht1e_human
NAME
8UGY
ORGANISM
Human (Homo sapiens)
PROTEIN NAME
5ht1e_human
SOURCE
SWISSPROT
SEQUENCE
Perspective:
Wild-type
Construct
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N-term | |||||||||
M
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N
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I
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T
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N
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C
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T
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T
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E
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A
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10 |
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TM1 | |||||||||
S
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M
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A
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I
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R
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P
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K
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T
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I
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T
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20 |
E
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K
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M
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L
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I
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C
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M
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T
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L
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V
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30 |
V
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I
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T
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T
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L
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T
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T
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L
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L
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N
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40 |
L
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A
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V
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I
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M
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A
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I
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G
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T
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T
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50 |
ICL1 | TM2 | ||||||||
K
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K
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L
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H
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Q
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P
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A
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N
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Y
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L
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60 |
I
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C
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S
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L
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A
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V
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T
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D
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L
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L
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70 |
V
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A
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V
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L
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V
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M
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P
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L
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S
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I
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80 |
ECL1 | |||||||||
I
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Y
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I
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V
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M
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D
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R
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W
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K
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L
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90 |
TM3 | |||||||||
G
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Y
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F
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L
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C
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E
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V
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W
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L
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S
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100 |
V
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D
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M
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T
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C
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C
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T
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C
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S
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I
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110 |
L
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H
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L
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C
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V
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I
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A
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L
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D
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R
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120 |
ICL2 | |||||||||
Y
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W
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A
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I
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T
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N
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A
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I
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E
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Y
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130 |
TM4 | |||||||||
A
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R
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K
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R
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T
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A
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K
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R
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A
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A
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140 |
L
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M
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I
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L
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T
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V
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W
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T
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I
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S
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150 |
I
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F
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I
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S
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M
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P
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P
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L
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F
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W
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160 |
ECL2 | |||||||||
R
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S
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H
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R
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R
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L
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S
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P
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P
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P
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170 |
S
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Q
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C
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T
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I
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Q
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H
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D
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H
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V
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180 |
TM5 | |||||||||
I
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Y
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T
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I
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Y
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S
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T
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L
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G
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A
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190 |
F
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Y
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I
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P
|
L
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T
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L
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I
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L
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I
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200 |
L
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Y
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Y
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R
|
I
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Y
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H
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A
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A
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K
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210 |
S
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L
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Y
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Q
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K
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R
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G
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S
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S
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R
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220 |
ICL3 | |||||||||
H
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L
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S
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N
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R
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S
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T
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D
|
S
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Q
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230 |
N
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S
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F
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A
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S
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C
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K
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L
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T
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Q
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240 |
T
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F
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C
|
V
|
S
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D
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F
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S
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T
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S
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250 |
D
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P
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T
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T
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E
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F
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E
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K
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F
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H
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260 |
A
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S
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I
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R
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I
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P
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P
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F
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D
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N
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270 |
D
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L
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D
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H
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P
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G
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E
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R
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Q
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Q
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280 |
TM6 | |||||||||
I
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S
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S
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T
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R
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E
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R
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K
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A
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A
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290 |
R
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I
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L
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G
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L
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I
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L
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G
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A
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F
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300 |
I
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L
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S
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W
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L
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P
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F
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F
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I
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K
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310 |
E
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L
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I
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V
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G
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L
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S
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I
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Y
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T
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320 |
ECL3 | TM7 | ||||||||
V
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S
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S
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E
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V
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A
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D
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F
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L
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T
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330 |
W
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L
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G
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Y
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V
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N
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S
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L
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I
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N
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340 |
H8 | |||||||||
P
|
L
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L
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Y
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T
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S
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F
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N
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E
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D
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350 |
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||||||||
F
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K
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L
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A
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F
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K
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K
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L
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I
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R
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360 |
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C-term | |||||
C
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R
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E
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H
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T
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|
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|||||||||
TM1 | |||||||||
|
T
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E
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K
|
M
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L
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I
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C
|
M
|
T
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28 |
L
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V
|
V
|
I
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T
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T
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L
|
T
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T
|
L
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38 |
L
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N
|
L
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A
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V
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I
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M
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A
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I
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G
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48 |
ICL1 | TM2 | ||||||||
T
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T
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K
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K
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L
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H
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Q
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P
|
A
|
N
|
58 |
Y
|
L
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I
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C
|
S
|
L
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A
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V
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T
|
D
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68 |
L
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L
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V
|
A
|
V
|
L
|
V
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M
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P
|
L
|
78 |
S
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I
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I
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Y
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I
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V
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M
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D
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R
|
W
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88 |
ECL1 | TM3 | ||||||||
K
|
L
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G
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Y
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F
|
L
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C
|
E
|
V
|
W
|
98 |
L
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S
|
V
|
D
|
M
|
T
|
C
|
C
|
T
|
C
|
108 |
S
|
I
|
L
|
H
|
L
|
C
|
V
|
I
|
A
|
L
|
118 |
D
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R
|
Y
|
W
|
A
|
I
|
T
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N
|
A
|
I
|
128 |
ICL2 | TM4 | ||||||||
E
|
Y
|
A
|
R
|
K
|
R
|
T
|
A
|
K
|
R
|
138 |
A
|
A
|
L
|
M
|
I
|
L
|
T
|
V
|
W
|
T
|
148 |
I
|
S
|
I
|
F
|
I
|
S
|
M
|
P
|
P
|
L
|
158 |
ECL2 | |||||||||
F
|
W
|
R
|
S
|
H
|
R
|
R
|
L
|
S
|
P
|
168 |
P
|
P
|
S
|
Q
|
C
|
T
|
I
|
Q
|
H
|
D
|
178 |
TM5 | |||||||||
H
|
V
|
I
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Y
|
T
|
I
|
Y
|
S
|
T
|
L
|
188 |
G
|
A
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F
|
Y
|
I
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P
|
L
|
T
|
L
|
I
|
198 |
L
|
I
|
L
|
Y
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Y
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R
|
I
|
Y
|
H
|
A
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208 |
A
|
K
|
S
|
L
|
Y
|
Q
|
K
|
R
|
G
|
S
|
218 |
ICL3 | |||||||||
S
|
R
|
H
|
L
|
S
|
N
|
R
|
S
|
T
|
D
|
228 |
S
|
Q
|
N
|
S
|
F
|
A
|
S
|
C
|
K
|
L
|
238 |
T
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Q
|
T
|
F
|
C
|
V
|
S
|
D
|
F
|
S
|
248 |
T
|
S
|
D
|
P
|
T
|
T
|
E
|
F
|
E
|
K
|
258 |
F
|
H
|
A
|
S
|
I
|
R
|
I
|
P
|
P
|
F
|
268 |
D
|
N
|
D
|
L
|
D
|
H
|
P
|
G
|
E
|
R
|
278 |
TM6 | |||||||||
Q
|
Q
|
I
|
S
|
S
|
T
|
R
|
E
|
R
|
K
|
288 |
A
|
A
|
R
|
I
|
L
|
G
|
L
|
I
|
L
|
G
|
298 |
A
|
F
|
I
|
L
|
S
|
W
|
L
|
P
|
F
|
F
|
308 |
I
|
K
|
E
|
L
|
I
|
V
|
G
|
L
|
S
|
I
|
318 |
ECL3 | TM7 | ||||||||
Y
|
T
|
V
|
S
|
S
|
E
|
V
|
A
|
D
|
F
|
328 |
L
|
T
|
W
|
L
|
G
|
Y
|
V
|
N
|
S
|
L
|
338 |
I
|
N
|
P
|
L
|
L
|
Y
|
T
|
S
|
F
|
N
|
348 |
|
|||||||||||||||||||||
H8 | |||||||||||||||||||||
E
|
D
|
F
|
K
|
L
|
A
|
F
|
K
|
K
|
L
|
|
|||||||||||
358 |
SCHEMATIC
Perspective:
Wild-type
Construct
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DIAGRAMS
MUTATIONS
Position | Wild-type | Mutated |
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DELETIONS
MODIFICATIONS
AUXILIARY PROTEINS
EXPRESSION
Expression method | Host cell type | Host cell | Remarks |
---|---|---|---|
SOLUBILIZATION
Solvent type | Item | Concentration |
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Remarks:
PURIFICATION
Purification type | Description |
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Remarks:
CRYSTALLIZATION
METHOD:
TYPE: ()
PROTEIN CONCENTRATION:
Temperature:
ph : -
Remarks:
Chemical lists
Type | Item | Concentration |
---|