hrh1_human
NAME
8X63
ORGANISM
Human (Homo sapiens)
PROTEIN NAME
hrh1_human
SOURCE
SWISSPROT
SEQUENCE
Perspective:
Wild-type
Construct
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N-term | |||||||||
M
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S
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L
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P
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N
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S
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S
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C
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L
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L
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10 |
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|
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E
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D
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K
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M
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C
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E
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G
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N
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K
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T
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20 |
T
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M
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A
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S
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P
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Q
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L
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M
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P
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L
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30 |
TM1 | |||||||||
V
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V
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V
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L
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S
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T
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I
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C
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L
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V
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40 |
T
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V
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G
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L
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N
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L
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L
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V
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L
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Y
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50 |
ICL1 | |||||||||
A
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V
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R
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S
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E
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R
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K
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L
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H
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T
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60 |
TM2 | |||||||||
V
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G
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N
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L
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Y
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I
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V
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S
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L
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S
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70 |
V
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A
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D
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L
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I
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V
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G
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A
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V
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V
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80 |
M
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P
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M
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N
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I
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L
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Y
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L
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L
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M
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90 |
ECL1 | TM3 | ||||||||
S
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K
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W
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S
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L
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G
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R
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P
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L
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C
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100 |
L
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F
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W
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L
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S
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M
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D
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Y
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V
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A
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110 |
S
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T
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A
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S
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I
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F
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S
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V
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F
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I
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120 |
L
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C
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I
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D
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R
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Y
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R
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S
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V
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Q
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130 |
ICL2 | |||||||||
Q
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P
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L
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R
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Y
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L
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K
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Y
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R
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T
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140 |
TM4 | |||||||||
K
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T
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R
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A
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S
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A
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T
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I
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L
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G
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150 |
A
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W
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F
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L
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S
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F
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L
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W
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V
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I
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160 |
ECL2 | |||||||||
P
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I
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L
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G
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W
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N
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H
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F
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M
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Q
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170 |
Q
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T
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S
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V
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R
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R
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E
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D
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K
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C
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180 |
TM5 | |||||||||
E
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T
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D
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F
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Y
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D
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V
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T
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W
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F
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190 |
K
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V
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M
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T
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A
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I
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I
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N
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F
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Y
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200 |
L
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P
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T
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L
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L
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M
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L
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W
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F
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Y
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210 |
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|||||||
A
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K
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I
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Y
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K
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A
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V
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R
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Q
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H
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220 |
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C
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Q
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H
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R
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E
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L
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I
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N
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R
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S
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230 |
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ICL3 | |||||||||
L
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P
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S
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F
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S
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E
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I
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K
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L
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R
|
240 |
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P
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E
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N
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P
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K
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G
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D
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A
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K
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K
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250 |
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P
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G
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K
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E
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S
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P
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W
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E
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V
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L
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260 |
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K
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R
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K
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P
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K
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D
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A
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G
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G
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G
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270 |
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S
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V
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L
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K
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S
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P
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S
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Q
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T
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P
|
280 |
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K
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E
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M
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K
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S
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P
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V
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V
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F
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S
|
290 |
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Q
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E
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D
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D
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R
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E
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V
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D
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K
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L
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300 |
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Y
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C
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F
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P
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L
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D
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I
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V
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H
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M
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310 |
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|
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Q
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A
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A
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A
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E
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G
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S
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S
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R
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D
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320 |
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Y
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V
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A
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V
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N
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R
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S
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H
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G
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Q
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330 |
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|
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L
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K
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T
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D
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E
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Q
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G
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L
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N
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T
|
340 |
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|
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H
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G
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A
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S
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E
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I
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S
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E
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D
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Q
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350 |
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|
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M
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L
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G
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D
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S
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Q
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S
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F
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S
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R
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360 |
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|
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T
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D
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S
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D
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T
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T
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T
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E
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T
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A
|
370 |
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|
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|
|
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P
|
G
|
K
|
G
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K
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L
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R
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S
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G
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S
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380 |
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|
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N
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T
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G
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L
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D
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Y
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I
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K
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F
|
T
|
390 |
|
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|
|
|
|
|
|
|
W
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K
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R
|
L
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R
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S
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H
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S
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R
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Q
|
400 |
|
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|||
TM6 | |||||||||
Y
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V
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S
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G
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L
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H
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M
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N
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R
|
E
|
410 |
R
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K
|
A
|
A
|
K
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Q
|
L
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G
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F
|
I
|
420 |
M
|
A
|
A
|
F
|
I
|
L
|
C
|
W
|
I
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P
|
430 |
Y
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F
|
I
|
F
|
F
|
M
|
V
|
I
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A
|
F
|
440 |
ECL3 | TM7 | ||||||||
C
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K
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N
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C
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C
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N
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E
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H
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L
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H
|
450 |
M
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F
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T
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I
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W
|
L
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G
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Y
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I
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N
|
460 |
S
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T
|
L
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N
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P
|
L
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I
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Y
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P
|
L
|
470 |
H8 | |||||||||
C
|
N
|
E
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N
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F
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K
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K
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T
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F
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K
|
480 |
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||||||
C-term | |||||||||
R
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I
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L
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H
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I
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R
|
S
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|||
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|||||||||
N-term | |||||||||
|
T
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T
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M
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A
|
S
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P
|
Q
|
L
|
M
|
28 |
TM1 | |||||||||
P
|
L
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V
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V
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V
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L
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S
|
T
|
I
|
C
|
38 |
L
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V
|
T
|
V
|
G
|
L
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N
|
L
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L
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V
|
48 |
L
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Y
|
A
|
V
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R
|
S
|
E
|
R
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K
|
L
|
58 |
ICL1 | TM2 | ||||||||
H
|
T
|
V
|
G
|
N
|
L
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Y
|
I
|
V
|
S
|
68 |
L
|
S
|
V
|
A
|
D
|
L
|
I
|
V
|
G
|
A
|
78 |
V
|
V
|
M
|
P
|
M
|
N
|
I
|
L
|
Y
|
L
|
88 |
ECL1 | TM3 | ||||||||
L
|
M
|
S
|
K
|
W
|
S
|
L
|
G
|
R
|
P
|
98 |
L
|
C
|
L
|
F
|
W
|
L
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S
|
M
|
D
|
Y
|
108 |
V
|
A
|
S
|
T
|
A
|
S
|
I
|
F
|
S
|
V
|
118 |
F
|
I
|
L
|
C
|
I
|
D
|
R
|
Y
|
R
|
S
|
128 |
ICL2 | |||||||||
V
|
Q
|
Q
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P
|
L
|
R
|
Y
|
L
|
K
|
Y
|
138 |
TM4 | |||||||||
R
|
T
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K
|
T
|
R
|
A
|
S
|
A
|
T
|
I
|
148 |
L
|
G
|
A
|
W
|
F
|
L
|
S
|
F
|
L
|
W
|
158 |
ECL2 | |||||||||
V
|
I
|
P
|
I
|
L
|
G
|
W
|
N
|
H
|
F
|
168 |
M
|
Q
|
Q
|
T
|
S
|
V
|
R
|
R
|
E
|
D
|
178 |
K
|
C
|
E
|
T
|
D
|
F
|
Y
|
D
|
V
|
T
|
188 |
TM5 | |||||||||
W
|
F
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K
|
V
|
M
|
T
|
A
|
I
|
I
|
N
|
198 |
F
|
Y
|
L
|
P
|
T
|
L
|
L
|
M
|
L
|
W
|
208 |
|
|||||||||
F
|
Y
|
A
|
K
|
I
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Y
|
K
|
A
|
V
|
|
TM6 | |||||||||
N
|
R
|
E
|
R
|
K
|
A
|
A
|
K
|
Q
|
L
|
417 |
G
|
F
|
I
|
M
|
A
|
A
|
F
|
I
|
L
|
C
|
427 |
W
|
I
|
P
|
Y
|
F
|
I
|
F
|
F
|
M
|
V
|
437 |
ECL3 | |||||||||
I
|
A
|
F
|
C
|
K
|
N
|
C
|
C
|
N
|
E
|
447 |
TM7 | |||||||||
H
|
L
|
H
|
M
|
F
|
T
|
I
|
W
|
L
|
G
|
457 |
Y
|
I
|
N
|
S
|
T
|
L
|
N
|
P
|
L
|
I
|
467 |
H8 | |||||||||
Y
|
P
|
L
|
C
|
N
|
E
|
N
|
F
|
K
|
K
|
477 |
|
||||||
T
|
F
|
K
|
R
|
I
|
L
|
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SCHEMATIC
Perspective:
Wild-type
Construct
|
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DIAGRAMS
MUTATIONS
Position | Wild-type | Mutated |
---|
DELETIONS
MODIFICATIONS
AUXILIARY PROTEINS
EXPRESSION
Expression method | Host cell type | Host cell | Remarks |
---|---|---|---|
SOLUBILIZATION
Solvent type | Item | Concentration |
---|
Remarks:
PURIFICATION
Purification type | Description |
---|
Remarks:
CRYSTALLIZATION
METHOD:
TYPE: ()
PROTEIN CONCENTRATION:
Temperature:
ph : -
Remarks:
Chemical lists
Type | Item | Concentration |
---|