5ht2c_human
NAME
8ZMF
ORGANISM
Human (Homo sapiens)
PROTEIN NAME
5ht2c_human
SOURCE
SWISSPROT
SEQUENCE
Perspective:
Wild-type
Construct
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N-term | |||||||||
M
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V
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N
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L
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R
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N
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A
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V
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H
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S
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10 |
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|
|
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F
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L
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V
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H
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L
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I
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G
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L
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L
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V
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20 |
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|
|
|
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W
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Q
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S
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D
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I
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S
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V
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S
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P
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V
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30 |
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|
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A
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A
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I
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V
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T
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D
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I
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F
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N
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T
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40 |
S
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D
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G
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G
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R
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F
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K
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F
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P
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D
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50 |
TM1 | |||||||||
G
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V
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Q
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N
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W
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P
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A
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L
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S
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I
|
60 |
V
|
I
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I
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I
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I
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M
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T
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I
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G
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G
|
70 |
N
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I
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L
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V
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I
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M
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A
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V
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S
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M
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80 |
ICL1 | TM2 | ||||||||
E
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K
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K
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L
|
H
|
N
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A
|
T
|
N
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Y
|
90 |
F
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L
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M
|
S
|
L
|
A
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I
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A
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D
|
M
|
100 |
L
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V
|
G
|
L
|
L
|
V
|
M
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P
|
L
|
S
|
110 |
L
|
L
|
A
|
I
|
L
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Y
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D
|
Y
|
V
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W
|
120 |
ECL1 | TM3 | ||||||||
P
|
L
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P
|
R
|
Y
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L
|
C
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P
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V
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W
|
130 |
I
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S
|
L
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D
|
V
|
L
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F
|
S
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T
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A
|
140 |
S
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I
|
M
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H
|
L
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C
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A
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I
|
S
|
L
|
150 |
D
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R
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Y
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V
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A
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I
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R
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N
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P
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I
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160 |
ICL2 | TM4 | ||||||||
E
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H
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S
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R
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F
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N
|
S
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R
|
T
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K
|
170 |
A
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I
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M
|
K
|
I
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A
|
I
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V
|
W
|
A
|
180 |
I
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S
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I
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G
|
V
|
S
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V
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P
|
I
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P
|
190 |
ECL2 | |||||||||
V
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I
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G
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L
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R
|
D
|
E
|
E
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K
|
V
|
200 |
F
|
V
|
N
|
N
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T
|
T
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C
|
V
|
L
|
N
|
210 |
TM5 | |||||||||
D
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P
|
N
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F
|
V
|
L
|
I
|
G
|
S
|
F
|
220 |
V
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A
|
F
|
F
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I
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P
|
L
|
T
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I
|
M
|
230 |
V
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I
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T
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Y
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C
|
L
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T
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I
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Y
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V
|
240 |
|
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|
|
|||||
L
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R
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R
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Q
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A
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L
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M
|
L
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L
|
H
|
250 |
|
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ICL3 | |||||||||
G
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H
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T
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E
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E
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P
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P
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G
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L
|
S
|
260 |
|
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|
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|
|
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L
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D
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F
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L
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K
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C
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C
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K
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R
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N
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270 |
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|
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T
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A
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E
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E
|
E
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N
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S
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A
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N
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P
|
280 |
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|
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|
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N
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Q
|
D
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Q
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N
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A
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R
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R
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R
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K
|
290 |
|
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|
|
|
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|
|
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K
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K
|
E
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R
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R
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P
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R
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G
|
T
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M
|
300 |
TM6 | |||||||||
Q
|
A
|
I
|
N
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N
|
E
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R
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K
|
A
|
S
|
310 |
K
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V
|
L
|
G
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I
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V
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F
|
F
|
V
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F
|
320 |
L
|
I
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M
|
W
|
C
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P
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F
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F
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I
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T
|
330 |
N
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I
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L
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S
|
V
|
L
|
C
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E
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K
|
S
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340 |
ECL3 | TM7 | ||||||||
C
|
N
|
Q
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K
|
L
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M
|
E
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K
|
L
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L
|
350 |
N
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V
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F
|
V
|
W
|
I
|
G
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Y
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V
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C
|
360 |
S
|
G
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I
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N
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P
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L
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V
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Y
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T
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L
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370 |
H8 | |||||||||
F
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N
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K
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I
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Y
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R
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R
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A
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F
|
S
|
380 |
N
|
Y
|
L
|
R
|
C
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N
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Y
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K
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V
|
E
|
390 |
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|||
C-term | |||||||||
K
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K
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P
|
P
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V
|
R
|
Q
|
I
|
P
|
R
|
400 |
|
|
|
|
|
|
|
|
|
|
V
|
A
|
A
|
T
|
A
|
L
|
S
|
G
|
R
|
E
|
410 |
|
|
|
|
|
|
|
|
|
|
L
|
N
|
V
|
N
|
I
|
Y
|
R
|
H
|
T
|
N
|
420 |
|
|
|
|
|
|
|
|
|
|
E
|
P
|
V
|
I
|
E
|
K
|
A
|
S
|
D
|
N
|
430 |
|
|
|
|
|
|
|
|
|
|
E
|
P
|
G
|
I
|
E
|
M
|
Q
|
V
|
E
|
N
|
440 |
|
|
|
|
|
|
|
|
|
|
L
|
E
|
L
|
P
|
V
|
N
|
P
|
S
|
S
|
V
|
450 |
|
|
|
|
|
|
|
|
V
|
S
|
E
|
R
|
I
|
S
|
S
|
V
|
|
|||||||||
N-term | |||||||||
|
T
|
S
|
D
|
G
|
G
|
R
|
F
|
K
|
F
|
48 |
TM1 | |||||||||
P
|
D
|
G
|
V
|
Q
|
N
|
W
|
P
|
A
|
L
|
58 |
S
|
I
|
V
|
I
|
I
|
I
|
I
|
M
|
T
|
I
|
68 |
G
|
G
|
N
|
I
|
L
|
V
|
I
|
M
|
A
|
V
|
78 |
ICL1 | TM2 | ||||||||
S
|
M
|
E
|
K
|
K
|
L
|
H
|
N
|
A
|
T
|
88 |
N
|
Y
|
F
|
L
|
M
|
S
|
L
|
A
|
I
|
A
|
98 |
D
|
M
|
L
|
V
|
G
|
L
|
L
|
V
|
M
|
P
|
108 |
L
|
S
|
L
|
L
|
A
|
I
|
L
|
Y
|
D
|
Y
|
118 |
ECL1 | TM3 | ||||||||
V
|
W
|
P
|
L
|
P
|
R
|
Y
|
L
|
C
|
P
|
128 |
V
|
W
|
I
|
S
|
L
|
D
|
V
|
L
|
F
|
S
|
138 |
T
|
A
|
S
|
I
|
M
|
H
|
L
|
C
|
A
|
I
|
148 |
S
|
L
|
D
|
R
|
Y
|
V
|
A
|
I
|
R
|
N
|
158 |
ICL2 | |||||||||
P
|
I
|
E
|
H
|
S
|
R
|
F
|
N
|
S
|
R
|
168 |
TM4 | |||||||||
T
|
K
|
A
|
I
|
M
|
K
|
I
|
A
|
I
|
V
|
178 |
W
|
A
|
I
|
S
|
I
|
G
|
V
|
S
|
V
|
P
|
188 |
I
|
P
|
V
|
I
|
G
|
L
|
R
|
D
|
E
|
E
|
198 |
ECL2 | |||||||||
K
|
V
|
F
|
V
|
N
|
N
|
T
|
T
|
C
|
V
|
208 |
TM5 | |||||||||
L
|
N
|
D
|
P
|
N
|
F
|
V
|
L
|
I
|
G
|
218 |
S
|
F
|
V
|
A
|
F
|
F
|
I
|
P
|
L
|
T
|
228 |
I
|
M
|
V
|
I
|
T
|
Y
|
C
|
L
|
T
|
I
|
238 |
|
|||||||||
Y
|
V
|
L
|
R
|
R
|
Q
|
A
|
|
Q
|
A
|
302 |
TM6 | |||||||||
I
|
N
|
N
|
E
|
R
|
K
|
A
|
S
|
K
|
V
|
312 |
L
|
G
|
I
|
V
|
F
|
F
|
V
|
F
|
L
|
I
|
322 |
M
|
W
|
C
|
P
|
F
|
F
|
I
|
T
|
N
|
I
|
332 |
ECL3 | |||||||||
L
|
S
|
V
|
L
|
C
|
E
|
K
|
S
|
C
|
N
|
342 |
TM7 | |||||||||
Q
|
K
|
L
|
M
|
E
|
K
|
L
|
L
|
N
|
V
|
352 |
F
|
V
|
W
|
I
|
G
|
Y
|
V
|
C
|
S
|
G
|
362 |
I
|
N
|
P
|
L
|
V
|
Y
|
T
|
L
|
F
|
N
|
372 |
H8 | |||||||||
K
|
I
|
Y
|
R
|
R
|
A
|
F
|
S
|
N
|
Y
|
382 |
C-term | |||||||||
L
|
R
|
C
|
N
|
Y
|
K
|
V
|
E
|
K
|
K
|
392 |
|
|
P
|
|
SCHEMATIC
Perspective:
Wild-type
Construct
|
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DIAGRAMS
MUTATIONS
Position | Wild-type | Mutated |
---|
DELETIONS
MODIFICATIONS
AUXILIARY PROTEINS
EXPRESSION
Expression method | Host cell type | Host cell | Remarks |
---|---|---|---|
SOLUBILIZATION
Solvent type | Item | Concentration |
---|
Remarks:
PURIFICATION
Purification type | Description |
---|
Remarks:
CRYSTALLIZATION
METHOD:
TYPE: ()
PROTEIN CONCENTRATION:
Temperature:
ph : -
Remarks:
Chemical lists
Type | Item | Concentration |
---|