ada2a_human
NAME
9CBL
ORGANISM
Human (Homo sapiens)
PROTEIN NAME
ada2a_human
SOURCE
SWISSPROT
SEQUENCE
Perspective:
Wild-type
Construct
|
|
|
|
|
|
|
|
|
|
N-term | |||||||||
M
|
F
|
R
|
Q
|
E
|
Q
|
P
|
L
|
A
|
E
|
10 |
|
|
|
|
|
|
|
|
|
|
G
|
S
|
F
|
A
|
P
|
M
|
G
|
S
|
L
|
Q
|
20 |
|
|
|
|
|
|
|
|
|
|
P
|
D
|
A
|
G
|
N
|
A
|
S
|
W
|
N
|
G
|
30 |
|
|
|
|
||||||
T
|
E
|
A
|
P
|
G
|
G
|
G
|
A
|
R
|
A
|
40 |
TM1 | |||||||||
T
|
P
|
Y
|
S
|
L
|
Q
|
V
|
T
|
L
|
T
|
50 |
L
|
V
|
C
|
L
|
A
|
G
|
L
|
L
|
M
|
L
|
60 |
L
|
T
|
V
|
F
|
G
|
N
|
V
|
L
|
V
|
I
|
70 |
ICL1 | |||||||||
I
|
A
|
V
|
F
|
T
|
S
|
R
|
A
|
L
|
K
|
80 |
TM2 | |||||||||
A
|
P
|
Q
|
N
|
L
|
F
|
L
|
V
|
S
|
L
|
90 |
A
|
S
|
A
|
D
|
I
|
L
|
V
|
A
|
T
|
L
|
100 |
V
|
I
|
P
|
F
|
S
|
L
|
A
|
N
|
E
|
V
|
110 |
ECL1 | TM3 | ||||||||
M
|
G
|
Y
|
W
|
Y
|
F
|
G
|
K
|
A
|
W
|
120 |
C
|
E
|
I
|
Y
|
L
|
A
|
L
|
D
|
V
|
L
|
130 |
F
|
C
|
T
|
S
|
S
|
I
|
V
|
H
|
L
|
C
|
140 |
A
|
I
|
S
|
L
|
D
|
R
|
Y
|
W
|
S
|
I
|
150 |
ICL2 | |||||||||
T
|
Q
|
A
|
I
|
E
|
Y
|
N
|
L
|
K
|
R
|
160 |
TM4 | |||||||||
T
|
P
|
R
|
R
|
I
|
K
|
A
|
I
|
I
|
I
|
170 |
T
|
V
|
W
|
V
|
I
|
S
|
A
|
V
|
I
|
S
|
180 |
ECL2 | |||||||||
F
|
P
|
P
|
L
|
I
|
S
|
I
|
E
|
K
|
K
|
190 |
G
|
G
|
G
|
G
|
G
|
P
|
Q
|
P
|
A
|
E
|
200 |
TM5 | |||||||||
P
|
R
|
C
|
E
|
I
|
N
|
D
|
Q
|
K
|
W
|
210 |
Y
|
V
|
I
|
S
|
S
|
C
|
I
|
G
|
S
|
F
|
220 |
F
|
A
|
P
|
C
|
L
|
I
|
M
|
I
|
L
|
V
|
230 |
Y
|
V
|
R
|
I
|
Y
|
Q
|
I
|
A
|
K
|
R
|
240 |
|
|
|
|
|
|
|
|
||
R
|
T
|
R
|
V
|
P
|
P
|
S
|
R
|
R
|
G
|
250 |
|
|
|
|
|
|
|
|
|
|
ICL3 | |||||||||
P
|
D
|
A
|
V
|
A
|
A
|
P
|
P
|
G
|
G
|
260 |
|
|
|
|
|
|
|
|
|
|
T
|
E
|
R
|
R
|
P
|
N
|
G
|
L
|
G
|
P
|
270 |
|
|
|
|
|
|
|
|
|
|
E
|
R
|
S
|
A
|
G
|
P
|
G
|
G
|
A
|
E
|
280 |
|
|
|
|
|
|
|
|
|
|
A
|
E
|
P
|
L
|
P
|
T
|
Q
|
L
|
N
|
G
|
290 |
|
|
|
|
|
|
|
|
|
|
A
|
P
|
G
|
E
|
P
|
A
|
P
|
A
|
G
|
P
|
300 |
|
|
|
|
|
|
|
|
|
|
R
|
D
|
T
|
D
|
A
|
L
|
D
|
L
|
E
|
E
|
310 |
|
|
|
|
|
|
|
|
|
|
S
|
S
|
S
|
S
|
D
|
H
|
A
|
E
|
R
|
P
|
320 |
|
|
|
|
|
|
|
|
|
|
P
|
G
|
P
|
R
|
R
|
P
|
E
|
R
|
G
|
P
|
330 |
|
|
|
|
|
|
|
|
|
|
R
|
G
|
K
|
G
|
K
|
A
|
R
|
A
|
S
|
Q
|
340 |
|
|
|
|
|
|
|
|
|
|
V
|
K
|
P
|
G
|
D
|
S
|
L
|
P
|
R
|
R
|
350 |
|
|
|
|
|
|
|
|
|
|
G
|
P
|
G
|
A
|
T
|
G
|
I
|
G
|
T
|
P
|
360 |
|
|
|
|
|
|
|
|
|
|
A
|
A
|
G
|
P
|
G
|
E
|
E
|
R
|
V
|
G
|
370 |
|
|
|
|
|
|
|
|
|
|
TM6 | |||||||||
A
|
A
|
K
|
A
|
S
|
R
|
W
|
R
|
G
|
R
|
380 |
Q
|
N
|
R
|
E
|
K
|
R
|
F
|
T
|
F
|
V
|
390 |
L
|
A
|
V
|
V
|
I
|
G
|
V
|
F
|
V
|
V
|
400 |
C
|
W
|
F
|
P
|
F
|
F
|
F
|
T
|
Y
|
T
|
410 |
ECL3 | |||||||||
L
|
T
|
A
|
V
|
G
|
C
|
S
|
V
|
P
|
R
|
420 |
TM7 | |||||||||
T
|
L
|
F
|
K
|
F
|
F
|
F
|
W
|
F
|
G
|
430 |
Y
|
C
|
N
|
S
|
S
|
L
|
N
|
P
|
V
|
I
|
440 |
H8 | |||||||||
Y
|
T
|
I
|
F
|
N
|
H
|
D
|
F
|
R
|
R
|
450 |
A
|
F
|
K
|
K
|
I
|
L
|
C
|
R
|
G
|
D
|
460 |
|
|
|
|
|
|
C-term | |||||
R
|
K
|
R
|
I
|
V
|
|
|
|||||||||
N-term | |||||||||
|
G
|
G
|
G
|
A
|
R
|
A
|
T
|
P
|
Y
|
43 |
TM1 | |||||||||
S
|
L
|
Q
|
V
|
T
|
L
|
T
|
L
|
V
|
C
|
53 |
L
|
A
|
G
|
L
|
L
|
M
|
L
|
L
|
T
|
V
|
63 |
F
|
G
|
N
|
V
|
L
|
V
|
I
|
I
|
A
|
V
|
73 |
ICL1 | TM2 | ||||||||
F
|
T
|
S
|
R
|
A
|
L
|
K
|
A
|
P
|
Q
|
83 |
N
|
L
|
F
|
L
|
V
|
S
|
L
|
A
|
S
|
A
|
93 |
D
|
I
|
L
|
V
|
A
|
T
|
L
|
V
|
I
|
P
|
103 |
F
|
S
|
L
|
A
|
N
|
E
|
V
|
M
|
G
|
Y
|
113 |
ECL1 | TM3 | ||||||||
W
|
Y
|
F
|
G
|
K
|
A
|
W
|
C
|
E
|
I
|
123 |
Y
|
L
|
A
|
L
|
D
|
V
|
L
|
F
|
C
|
T
|
133 |
S
|
S
|
I
|
V
|
H
|
L
|
C
|
A
|
I
|
S
|
143 |
L
|
D
|
R
|
Y
|
W
|
S
|
I
|
T
|
Q
|
A
|
153 |
ICL2 | TM4 | ||||||||
I
|
E
|
Y
|
N
|
L
|
K
|
R
|
T
|
P
|
R
|
163 |
R
|
I
|
K
|
A
|
I
|
I
|
I
|
T
|
V
|
W
|
173 |
V
|
I
|
S
|
A
|
V
|
I
|
S
|
F
|
P
|
P
|
183 |
ECL2 | |||||||||
L
|
I
|
S
|
I
|
E
|
K
|
K
|
G
|
G
|
G
|
193 |
G
|
G
|
P
|
Q
|
P
|
A
|
E
|
P
|
R
|
C
|
203 |
TM5 | |||||||||
E
|
I
|
N
|
D
|
Q
|
K
|
W
|
Y
|
V
|
I
|
213 |
S
|
S
|
C
|
I
|
G
|
S
|
F
|
F
|
A
|
P
|
223 |
C
|
L
|
I
|
M
|
I
|
L
|
V
|
Y
|
V
|
R
|
233 |
|
|||||||||
I
|
Y
|
Q
|
I
|
A
|
K
|
R
|
R
|
T
|
|
TM6 | |||||||||
R
|
Q
|
N
|
R
|
E
|
K
|
R
|
F
|
T
|
F
|
389 |
V
|
L
|
A
|
V
|
V
|
I
|
G
|
V
|
F
|
V
|
399 |
V
|
C
|
W
|
F
|
P
|
F
|
F
|
F
|
T
|
Y
|
409 |
ECL3 | |||||||||
T
|
L
|
T
|
A
|
V
|
G
|
C
|
S
|
V
|
P
|
419 |
TM7 | |||||||||
R
|
T
|
L
|
F
|
K
|
F
|
F
|
F
|
W
|
F
|
429 |
G
|
Y
|
C
|
N
|
S
|
S
|
L
|
N
|
P
|
V
|
439 |
H8 | |||||||||
I
|
Y
|
T
|
I
|
F
|
N
|
H
|
D
|
F
|
R
|
449 |
R
|
A
|
F
|
K
|
K
|
I
|
L
|
C
|
R
|
G
|
459 |
|
|||||
C-term | |||||
D
|
|
||||
SCHEMATIC
Perspective:
Wild-type
Construct
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
DIAGRAMS
MUTATIONS
Position | Wild-type | Mutated |
---|
DELETIONS
MODIFICATIONS
AUXILIARY PROTEINS
EXPRESSION
Expression method | Host cell type | Host cell | Remarks |
---|---|---|---|
SOLUBILIZATION
Solvent type | Item | Concentration |
---|
Remarks:
PURIFICATION
Purification type | Description |
---|
Remarks:
CRYSTALLIZATION
METHOD:
TYPE: ()
PROTEIN CONCENTRATION:
Temperature:
ph : -
Remarks:
Chemical lists
Type | Item | Concentration |
---|