Structure information

A2A receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

3QAK

SPECIES

Homo sapiens

RESOLUTION

2.710

PREFERRED CHAIN

A

REFERENCE

10.1126/SCIENCE.1202793

PUBLICATION DATE

March 9, 2011

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
UK-432,097 V84 3.32x32 TM3 hydrophobic
UK-432,097 L85 3.33x33 TM3 hydrophobic
UK-432,097 T88 3.36x36 TM3 polar (hydrogen bond)
UK-432,097 Q89 3.37x37 TM3 Van der Waals
UK-432,097 L167 45.51x51 ECL2 Van der Waals
UK-432,097 L167 45.51x51 ECL2 hydrophobic
UK-432,097 F168 45.52x52 ECL2 aromatic (face-to-face)
UK-432,097 F168 45.52x52 ECL2 Van der Waals
UK-432,097 E169 ECL2 polar (charge-assisted hydrogen bond)
UK-432,097 W246 6.48x48 TM6 Van der Waals
UK-432,097 W246 6.48x48 TM6 hydrophobic
UK-432,097 L249 6.51x51 TM6 Van der Waals
UK-432,097 L249 6.51x51 TM6 hydrophobic
UK-432,097 H250 6.52x52 TM6 Van der Waals
UK-432,097 H250 6.52x52 TM6 polar (hydrogen bond)
UK-432,097 N253 6.55x55 TM6 polar (hydrogen bond)
UK-432,097 N253 6.55x55 TM6 polar (hydrogen bond)
UK-432,097 T256 6.58x58 TM6 Van der Waals
UK-432,097 H264 ECL3 Van der Waals
UK-432,097 L267 7.32x31 TM7 Van der Waals
UK-432,097 M270 7.35x34 TM7 hydrophobic
UK-432,097 M270 7.35x34 TM7 Van der Waals
UK-432,097 Y271 7.36x35 TM7 polar (hydrogen bond)
UK-432,097 Y271 7.36x35 TM7 Van der Waals
UK-432,097 Y271 7.36x35 TM7 aromatic (face-to-edge)
UK-432,097 I274 7.39x38 TM7 Van der Waals
UK-432,097 I274 7.39x38 TM7 hydrophobic
UK-432,097 S277 7.42x41 TM7 Van der Waals
UK-432,097 S277 7.42x41 TM7 polar (hydrogen bond)
UK-432,097 H278 7.43x42 TM7 Van der Waals
UK-432,097 H278 7.43x42 TM7 polar (hydrogen bond)

Ligands

UK-432,097

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Residue Diagrams

V N G L I A L V A I A L E V T I Y V S S 1 V S L A A A D I A V G L V A I P F A I T I 2 A L L S F I S S Q T L V L V F C A I F L 3 A K G I I A I C W V L S F A I G L T P M 4 Y V G L M L L L P V L V C A F F N F Y V M Y 5 A I I V G L F A L C W L P L H I I N C F 6 F P N V V S N T H S L V I A L Y M L W 7
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ICL1 S N L Q ICL1ECL1 F C A ECL1ICL2 P L R Y N G L V ICL2ECL2 W N N C G Q P K E G K N H S Q G C G E G Q V A C L F E D V V ECL2ICL3 Q P L P G ICL3ECL3 P D C S H A ECL3C-term K A A G T S A R V L A A H G S D G E Q V S L R L N G H P P G V W A N G S A P H P E R R P N G Y A L G L V S G G S A Q E S Q G N T G L P D V E L L S H E L K G V C P E P P G L D D P L A Q D G A G V S C-term M P I M G S S V Y I T V E L A I A V L A I L G N V L V C W A V W L N N V T N Y F V V S L A A A D I A V G V L A I P F A I T I S T G A C H G C L F I A C F V L V L T Q S S I F S L L A I A I D R Y I A I R I T G T R A K G I I A I C W V L S F A I G L T P M L G P M N Y M V Y F N F F A C V L V P L L L M L G V Y L R I F L A A R R Q L K Q M E S E R A R S T L Q K E V H A A K S L A I I V G L F A L C W L P L H I I N C F T F F C P L W L M Y L A I V L S H T N S V V N P F I Y A Y R I R E F R K H V L P F F R Q T I I R S R Q Q E
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Residue Table


GPCRdb(A)
GPCRdb(A)
A2A receptor
TM3
3x32 3.32x32 V84
3x33 3.33x33 L85
3x36 3.36x36 T88
3x37 3.37x37 Q89
ECL2
45x51 45.51x51 L167
45x52 45.52x52 F168
TM6
6x48 6.48x48 W246
6x51 6.51x51 L249
6x52 6.52x52 H250
6x55 6.55x55 N253
6x58 6.58x58 T256
TM7
7x31 7.32x31 L267
7x34 7.35x34 M270
7x35 7.36x35 Y271
7x38 7.39x38 I274
7x41 7.42x41 S277
7x42 7.43x42 H278