Structure information

M3 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

4U14

SPECIES

Rattus norvegicus

RESOLUTION

3.570

PREFERRED CHAIN

A

REFERENCE

10.1016/J.STR.2014.08.022

PUBLICATION DATE

Nov. 26, 2014

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
tiotropium Y148 3.33x33 TM3 hydrophobic
tiotropium W199 4.57x57 TM4 hydrophobic
tiotropium W503 6.48x48 TM6 hydrophobic
tiotropium Y506 6.51x51 TM6 aromatic (edge-to-face)
tiotropium N507 6.52x52 TM6 polar (hydrogen bond)
tiotropium N507 6.52x52 TM6 Van der Waals
tiotropium Y529 7.39x38 TM7 Van der Waals
tiotropium Y529 7.39x38 TM7 hydrophobic
tiotropium C532 7.42x41 TM7 Van der Waals
tiotropium C532 7.42x41 TM7 hydrophobic

Ligands

tiotropium

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Residue Diagrams

I N G I I T V L A L F G T L F A I F V V 1 L S L A C A D L I I G I V S M N L F T T Y 2 V L L N M V S A N S A V Y D I S L W L D 3 A G V M I G L A W V I S F V L W A P A I 4 Y L I T M I T V P M Y F A A I A T G F T I 5 S A I L L A F I I T W T P Y N I M V L V 6 V P N V T S N I Y C L W Y G L N W Y T 7
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ICL1 K Q L K ICL1ECL1 N R W A L ECL1ICL2 P L T Y R A K R ICL2ECL2 K R T V P P G E C F I Q F L S ECL2ICL3 Q A S G T E A E A E N F V H P T G S S R S C S S Y E L Q Q Q G V K R S S R R K Y G R C H F W F T T K S W K P S A E Q M D Q D H S S S D S W N N N D A A A S L E N S A S S D E E D I G S E T R A I Y S I V L K L P G H S S I L N S T K L P S S D N L Q V S N E D L G T V D V E R N A H K L Q A Q K S M G D G D N C Q K D F T K L P I Q L E S A V D T G K T S D T N S S A D K T T A T L P L S F K E A T L A K R F A L K T R S Q I T K R K ICL3ECL3 D S C I ECL3N-term M T L H S N S T T S P L F P N I S S S W V H S P S E A G L P L G T V T Q L G S Y N I S Q E T G N F S S N D T S S D P L G G H N-termC-term Q C D K R K R R K Q Q Y Q Q R Q S V I F H K R V P E Q A L C-term T I W Q V V F I A F L T G F L A L V T I I G N I L V I V A F K V N T V N N Y F L L S L A C A D L I I G V I S M N L F T T Y I I M G N L A C D L W L S I D Y V A S N A S V M N L L V I S F D R Y F S I T R T T K R A G V M I G L A W V I S F V L W A P A I L F W Q Y F V G E P T I T F G T A I A A F Y M P V T I M T I L Y W R I Y K E T E K R T K E L A G L R M S L I K E K K A A Q T L S A I L L A F I I T W T P Y N I M V L V N T F C P K T Y W N L G Y W L C Y I N S T V N P V C Y A L C N K T F K T F R T T L L L C
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Residue Table


GPCRdb(A)
GPCRdb(A)
M3 receptor
TM3
3x33 3.33x33 Y148
TM4
4x57 4.57x57 W199
TM6
6x48 6.48x48 W503
6x51 6.51x51 Y506
6x52 6.52x52 N507
TM7
7x38 7.39x38 Y529
7x41 7.42x41 C532