Structure information

M1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

5CXV

SPECIES

Homo sapiens

RESOLUTION

2.700

PREFERRED CHAIN

A

REFERENCE

10.1038/NATURE17188

PUBLICATION DATE

March 9, 2016

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
0HK Y106 3.33x33 TM3 aromatic (edge-to-face)
0HK S109 3.36x36 TM3 Van der Waals
0HK S109 3.36x36 TM3 polar (hydrogen bond)
0HK Q110 3.37x37 TM3 Van der Waals
0HK W157 4.57x57 TM4 Van der Waals
0HK W157 4.57x57 TM4 hydrophobic
0HK T192 5.42x43 TM5 polar (hydrogen bond)
0HK A193 5.43x44 TM5 Van der Waals
0HK A196 5.46x461 TM5 Van der Waals
0HK A196 5.46x461 TM5 hydrophobic
0HK W378 6.48x48 TM6 hydrophobic
0HK W378 6.48x48 TM6 Van der Waals
0HK Y381 6.51x51 TM6 Van der Waals
0HK Y381 6.51x51 TM6 hydrophobic
0HK N382 6.52x52 TM6 polar (hydrogen bond)
0HK N382 6.52x52 TM6 Van der Waals
0HK Y404 7.39x38 TM7 Van der Waals
0HK Y404 7.39x38 TM7 hydrophobic
0HK C407 7.42x41 TM7 hydrophobic
0HK C407 7.42x41 TM7 Van der Waals
0HK Y408 7.43x42 TM7 Van der Waals
0HK Y408 7.43x42 TM7 hydrophobic

Ligands

0HK

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Residue Diagrams

L N G T V T A L S L L G T T I G I F A V 1 L S L A C A D L I I G F T S M N L Y T T Y 2 L L L N M V S A N S A V Y D L A L W L D 3 A A L M I G L A W L V S F V L W A P A I 4 Y L T C M V T V P L Y F A A M A T G F T I 5 S A I L L A F I L T W T P Y N I M V L V 6 M P N I T S N V Y C L W Y G L E W L T 7
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ICL1 T E L K ICL1ECL1 H W A L ECL1ICL2 P L S Y R A K R ICL2ECL2 E R T V L A G Q C Y I Q F L S ECL2ICL3 Q G S E T P G K G G G S S S S S E R S Q P G A E G S P E T P P G R C C R C C R A P R L L Q A Y S W K E E E E E D E G S M E S L T S S E G E E P G S E V V I K M P M V D P E A Q A P T K Q P P R S S P N T V K R P T K K G R D R A G K G Q K P R G K E Q L A K R K ICL3ECL3 K D C V ECL3N-term M N T S A P P A V S P N I T V L A P G K N-termC-term R W D K R R W R K I P K R P G S V H R T P S R Q C C-term G P W Q V A F I G I T T G L L S L A T V T G N L L V L I S F K V N T V N N Y F L L S L A C A D L I I G T F S M N L Y T T Y L L M G G T L A C D L W L A L D Y V A S N A S V M N L L L I S F D R Y F S V T R T P R R A A L M I G L A W L V S F V L W A P A I L F W Q Y L V G Q P I I T F G T A M A A F Y L P V T V M C T L Y W R I Y R E T E N R A R E L A A L T F S L V K E K K A A R T L S A I L L A F I L T W T P Y N I M V L V S T F C P E T L W E L G Y W L C Y V N S T I N P M C Y A L C N K A F R L F R D T L L L C
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Residue Table


GPCRdb(A)
GPCRdb(A)
M1 receptor
TM3
3x33 3.33x33 Y106
3x36 3.36x36 S109
3x37 3.37x37 N110
TM4
4x57 4.57x57 W157
TM5
5x43 5.42x43 T192
5x44 5.43x44 A193
5x461 5.46x461 A196
TM6
6x48 6.48x48 W378
6x51 6.51x51 Y381
6x52 6.52x52 N382
TM7
7x38 7.39x38 Y404
7x41 7.42x41 C407
7x42 7.43x42 Y408