Structure information

A2A receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

5NLX

SPECIES

Homo sapiens

RESOLUTION

2.140

PREFERRED CHAIN

A

REFERENCE

10.1038/S41467-017-00630-4

PUBLICATION DATE

Sept. 27, 2017

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
ZM-241385 F177 45.52x52 ECL2 aromatic (face-to-face)
ZM-241385 F177 45.52x52 ECL2 polar (hydrogen bond)
ZM-241385 E178 ECL2 polar (charge-assisted hydrogen bond)
ZM-241385 M183 5.35x37 TM5 Van der Waals
ZM-241385 M186 5.38x40 TM5 polar (hydrogen bond)
ZM-241385 W351 6.48x48 TM6 Van der Waals
ZM-241385 W351 6.48x48 TM6 hydrophobic
ZM-241385 L354 6.51x51 TM6 polar (hydrogen bond)
ZM-241385 H355 6.52x52 TM6 aromatic (face-to-edge)
ZM-241385 H355 6.52x52 TM6 polar (hydrogen bond)
ZM-241385 N358 6.55x55 TM6 polar (hydrogen bond)
ZM-241385 N358 6.55x55 TM6 polar (hydrogen bond)
ZM-241385 H369 ECL3 aromatic (face-to-edge)
ZM-241385 H369 ECL3 polar (hydrogen bond)
ZM-241385 L372 7.32x31 TM7 polar (hydrogen bond)
ZM-241385 M375 7.35x34 TM7 polar (hydrogen bond)
ZM-241385 Y376 7.36x35 TM7 polar (hydrogen bond)
ZM-241385 I379 7.39x38 TM7 polar (hydrogen bond)

Ligands

ZM-241385

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Residue Diagrams

V N G L I A L V A I A L E V T I Y V S S 1 V S L A A A D I A V G L V A I P F A I T I 2 A L L S F I S S Q T L V L V F C A I F L 3 A K G I I A I C W V L S F A I G L T P M 4 Y V G L M L L L P V L V C A F F N F Y V M Y 5 A I I V G L F A L C W L P L H I I N C F 6 F P N V V S N T H S L V I A L Y M L W 7
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ICL1 S N L Q ICL1ECL1 F C A ECL1ICL2 P L R Y N G L V ICL2ECL2 W N N C G Q P K E G K N H S Q G C G E G Q V A C L F E D V V ECL2ICL3 Q P L P G ICL3ECL3 P D C S H A ECL3C-term K A A G T S A R V L A A H G S D G E Q V S L R L N G H P P G V W A N G S A P H P E R R P N G Y A L G L V S G G S A Q E S Q G N T G L P D V E L L S H E L K G V C P E P P G L D D P L A Q D G A G V S C-term M P I M G S S V Y I T V E L A I A V L A I L G N V L V C W A V W L N N V T N Y F V V S L A A A D I A V G V L A I P F A I T I S T G A C H G C L F I A C F V L V L T Q S S I F S L L A I A I D R Y I A I R I T G T R A K G I I A I C W V L S F A I G L T P M L G P M N Y M V Y F N F F A C V L V P L L L M L G V Y L R I F L A A R R Q L K Q M E S E R A R S T L Q K E V H A A K S L A I I V G L F A L C W L P L H I I N C F T F F C P L W L M Y L A I V L S H T N S V V N P F I Y A Y R I R E F R K H V L P F F R Q T I I R S R Q Q E
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Residue Table


GPCRdb(A)
GPCRdb(A)
A2A receptor
ECL2
45x52 45.52x52 F168
TM5
5x37 5.35x37 M174
5x40 5.38x40 M177
TM6
6x48 6.48x48 W246
6x51 6.51x51 L249
6x52 6.52x52 H250
6x55 6.55x55 N253
TM7
7x31 7.32x31 L267
7x34 7.35x34 M270
7x35 7.36x35 Y271
7x38 7.39x38 I274