Structure information

M2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

5ZK3

SPECIES

Homo sapiens

RESOLUTION

2.600

PREFERRED CHAIN

A

REFERENCE

10.1038/S41589-018-0152-Y

PUBLICATION DATE

Nov. 21, 2018

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL558910 D103 3.32x32 TM3 polar (charge-assisted hydrogen bond)
CHEMBL558910 Y104 3.33x33 TM3 Van der Waals
CHEMBL558910 Y104 3.33x33 TM3 aromatic (edge-to-face)
CHEMBL558910 S107 3.36x36 TM3 Van der Waals
CHEMBL558910 N108 3.37x37 TM3 Van der Waals
CHEMBL558910 W155 4.57x57 TM4 Van der Waals
CHEMBL558910 W155 4.57x57 TM4 hydrophobic
CHEMBL558910 F181 ECL2 hydrophobic
CHEMBL558910 F181 ECL2 Van der Waals
CHEMBL558910 T187 5.39x40 TM5 Van der Waals
CHEMBL558910 T190 5.42x43 TM5 Van der Waals
CHEMBL558910 A191 5.43x44 TM5 hydrophobic
CHEMBL558910 A191 5.43x44 TM5 Van der Waals
CHEMBL558910 A194 5.46x461 TM5 hydrophobic
CHEMBL558910 A194 5.46x461 TM5 Van der Waals
CHEMBL558910 W400 6.48x48 TM6 Van der Waals
CHEMBL558910 W400 6.48x48 TM6 aromatic (edge-to-face)
CHEMBL558910 Y403 6.51x51 TM6 hydrophobic
CHEMBL558910 Y403 6.51x51 TM6 Van der Waals
CHEMBL558910 N404 6.52x52 TM6 polar (hydrogen bond)
CHEMBL558910 N404 6.52x52 TM6 Van der Waals
CHEMBL558910 Y426 7.39x38 TM7 hydrophobic
CHEMBL558910 Y426 7.39x38 TM7 Van der Waals
CHEMBL558910 C429 7.42x41 TM7 Van der Waals

Ligands

CHEMBL558910

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Residue Diagrams

I N G I I T V L S L S G A V L V I F V V 1 F S L A C A D L I I G F V S M N L Y T L Y 2 I L L N M V S A N S V V Y D L A L W L D 3 A G M M I A A A W V L S F I L W A P A I 4 Y L V T M I I V P L Y F A A I A T G F T V 5 L A I L L A F I I T W A P Y N V M V L I 6 A P N I T S N I Y C L W Y G I T W V T 7
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ICL1 R H L Q ICL1ECL1 Y W P L ECL1ICL2 P L T Y P V K R ICL2ECL2 V R T V E D G E C Y I Q F F S ECL2ICL3 P V A N Q D P V S P S L V Q G R I V K P N N N N M P S S D D G L E H N K I Q N G K A P R D P V T E N C V Q G E E K E S S N D S T S V S A V A S N M R D D E I T Q D E N T V S T S L G H S K D E N S K Q T C I R I G T K T P K S D S C T P T N T T V E V V G S S G Q N G D E K Q N I V A R K I V K M T K Q P A K K ICL3ECL3 A P C I ECL3N-term M N N S T N S S N N S L A L T S P Y N-termC-term C H Y K N I G A T R C-term K T F E V V F I V L V A G S L S L V T I I G N I L V M V S I K V N T V N N Y F L F S L A C A D L I I G V F S M N L Y T L Y T V I G G P V V C D L W L A L D Y V V S N A S V M N L L I I S F D R Y F C V T K T T K M A G M M I A A A W V L S F I L W A P A I L F W Q F I V G N A A V T F G T A I A A F Y L P V I I M T V L Y W H I S R A S K S R I K K D K K E K P P P S R E K K V T R T I L A I L L A F I I T W A P Y N V M V L I N T F C P N T V W T I G Y W L C Y I N S T I N P A C Y A L C N A T F K H F K K T L L M
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Residue Table


GPCRdb(A)
GPCRdb(A)
M2 receptor
TM3
3x32 3.32x32 D103
3x33 3.33x33 Y104
3x36 3.36x36 S107
3x37 3.37x37 N108
TM4
4x57 4.57x57 W155
TM5
5x40 5.39x40 T187
5x43 5.42x43 T190
5x44 5.43x44 A191
5x461 5.46x461 A194
TM6
6x48 6.48x48 W400
6x51 6.51x51 Y403
6x52 6.52x52 N404
TM7
7x38 7.39x38 Y426
7x41 7.42x41 C429