Structure information

CB2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

5ZTY

SPECIES

Homo sapiens

RESOLUTION

2.800

PREFERRED CHAIN

A

REFERENCE

10.1016/J.CELL.2018.12.011

PUBLICATION DATE

Jan. 30, 2019

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
AM10257 F87 2.57x57 TM2 hydrophobic
AM10257 F91 2.61x61 TM2 hydrophobic
AM10257 F94 2.64x64 TM2 hydrophobic
AM10257 I110 3.29x29 TM3 hydrophobic
AM10257 F117 3.36x36 TM3 aromatic (face-to-edge)
AM10257 F183 ECL2 aromatic (edge-to-face)
AM10257 W194 5.43x43 TM5 aromatic (edge-to-face)
AM10257 W258 6.48x48 TM6 aromatic (face-to-edge)
AM10257 V261 6.51x51 TM6 hydrophobic
AM10257 L262 6.52x52 TM6 hydrophobic
AM10257 M265 6.55x55 TM6 hydrophobic

Ligands

AM10257

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Residue Diagrams

V N E L A S L L G L L T C L V A V A T K 1 G S L A G A D F L A S V V F A C S F V N 2 L L L S G V S A T F T M T V S G I K L L 3 A L V T L G I M W V L S A L V S Y L P L 4 Y T Y I I G S F L F A I F L L W S L L Y 5 G L V L A V L L I C W F P V L A L M A H 6 V P N V M S N I L C L M S C F A F A K 7
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ICL1 H Q L R R ICL1ECL1 F H G V D ECL1ICL2 P P S Y K A L L ICL2ECL2 W T C C P R P C S E L F P L I ECL2ICL3 H Q D R Q V P G M A R M ICL3ECL3 T L ECL3N-term M E E C W V T E I A N G S K D G L D S N P M K D Y M I L N-termC-term C V R G L G S E A K E E A P R S S V T E T E A D G K I T P W P D S R D L D L S D C C-term S G P Q K T A V A V L C T L L G L L S A L E N V A V L Y L I L S S K P S Y L F I G S L A G A D F L A S V V F A C S F V N F H V S K A V F L L K I G S V T M T F T A S V G S L L L T A I D R Y L C L R Y T R G R A L V T L G I M W V L S A L V S Y L P L M G P N D Y L L S W L L F I A F L F S G I I Y T Y G H V L W K A H Q H V A S L S G R L D V R L A K T L G L V L A V L L I C W F P V L A L M A H S L A T S D Q V K K A F A F C S M L C L I N S M V N P V I Y A L R S G E A H H W K K I R S S C L A H
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Residue Table


GPCRdb(A)
GPCRdb(A)
CB2 receptor
TM2
2x57 2.57x57 F87
2x61 2.61x61 F91
2x64 2.64x64 F94
TM3
3x29 3.29x29 I110
3x36 3.36x36 F117
TM5
5x43 5.43x43 W194
TM6
6x48 6.48x48 W258
6x51 6.51x51 V261
6x52 6.52x52 L262
6x55 6.55x55 M265