Structure information

5-HT2B receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6DS0

SPECIES

Homo sapiens

RESOLUTION

3.190

PREFERRED CHAIN

A

REFERENCE

10.1038/s41594-018-0116-7

PUBLICATION DATE

Aug. 29, 2018

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
LY266097 W131 3.28x28 TM3 hydrophobic
LY266097 D135 3.32x32 TM3 polar (charge-assisted hydrogen bond)
LY266097 V136 3.33x33 TM3 hydrophobic
LY266097 V136 3.33x33 TM3 Van der Waals
LY266097 S139 3.36x36 TM3 Van der Waals
LY266097 L209 45.52x52 ECL2 Van der Waals
LY266097 F217 5.38x39 TM5 hydrophobic
LY266097 F217 5.38x39 TM5 Van der Waals
LY266097 S222 5.43x44 TM5 Van der Waals
LY266097 F340 6.51x51 TM6 hydrophobic
LY266097 F340 6.51x51 TM6 Van der Waals
LY266097 F341 6.52x52 TM6 hydrophobic
LY266097 N344 6.55x55 TM6 Van der Waals
LY266097 L362 7.35x34 TM7 Van der Waals
LY266097 E363 7.36x35 TM7 Van der Waals
LY266097 V366 7.39x38 TM7 hydrophobic
LY266097 V366 7.39x38 TM7 Van der Waals
LY266097 Y370 7.43x42 TM7 Van der Waals

Ligands

LY266097

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Residue Diagrams

T N G G I T P I I V M L I L L A A W H L K 1 M S L A V A D L L V G F L V M P I A L L T 2 A C L H M I S A T S F L V D L F L W A P 3 A F I K I T V V W L I S I G I A I P V 4 Y T V I M I A L P T F F A A L S G F L M F 5 G I V F F L F L L M W C P F F I T N I T 6 L P N V G S S V Y G I W V F I E L L M 7
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ICL1 K K L Q ICL1ECL1 E A M W P L ECL1ICL2 P I Q A N Q Y N ICL2ECL2 I E T D V D N P N N I T C V L T K E R ECL2ICL3 P Q R L T W L T V S T V F Q R D E T P C S S P E K V A M L D G S R K D K A L P N S G D E T L M R R T S T I G K K S ICL3ECL3 D S C ECL3N-term M A L S Y R V S E L Q S T I P E H I L Q S T F V H V I S S N W S G L Q T E S I P E E M K Q I V E E Q G N N-termC-term T C N Y R A T K S V K T L R K R S S K I Y F R N P M A E N S K F F K K H G I R N G I N P A M Y Q S P M R L R S S T I Q S S S I I L L D T L L L T E N E G D K T E E Q V S Y V C-term K L H W A A L L I L M V I I P T I G G N T L V I L A V S L E Y A T N Y F L M S L A V A D L L V G L F V M P I A L L T I M F P L V L C P A W L F L D V L F S T A S I M H L C A I S V D R Y I A I K K S R A T A F I K I T V V W L I S I G I A I P V P I K G F G D F M L F G S L A A F F T P L A I M I V T Y F L T I H A L Q K K A Y L V K N K P V Q T I S N E Q R A S K V L G I V F F L F L L M W C P F F I T N I T L V L C N Q T T L Q M L L E I F V W I G Y V S S G V N P L V Y T L F N K T F G R F R D A Y I
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Residue Table


GPCRdb(A)
GPCRdb(A)
5-HT2B receptor
TM3
3x28 3.28x28 W131
3x32 3.32x32 D135
3x33 3.33x33 V136
3x36 3.36x36 S139
ECL2
45x52 45.52x52 L209
TM5
5x39 5.38x39 F217
5x44 5.43x44 S222
TM6
6x51 6.51x51 F340
6x52 6.52x52 F341
6x55 6.55x55 N344
TM7
7x34 7.35x34 L362
7x35 7.36x35 E363
7x38 7.39x38 V366
7x42 7.43x42 Y370