Structure information

β1-adrenoceptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6IBL

SPECIES

Meleagris gallopavo

RESOLUTION

2.700

PREFERRED CHAIN

A

REFERENCE

10.1038/S41586-020-2419-1

PUBLICATION DATE

Jan. 9, 2019

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
ARFORMOTEROL W117 3.28x28 TM3 hydrophobic
ARFORMOTEROL D121 3.32x32 TM3 polar (charge-assisted hydrogen bond)
ARFORMOTEROL V122 3.33x33 TM3 hydrophobic
ARFORMOTEROL V122 3.33x33 TM3 Van der Waals
ARFORMOTEROL V125 3.36x36 TM3 hydrophobic
ARFORMOTEROL V125 3.36x36 TM3 Van der Waals
ARFORMOTEROL D200 45.51x51 ECL2 Van der Waals
ARFORMOTEROL F201 45.52x52 ECL2 Van der Waals
ARFORMOTEROL F201 45.52x52 ECL2 hydrophobic
ARFORMOTEROL Y207 5.38x39 TM5 Van der Waals
ARFORMOTEROL A208 5.39x40 TM5 Van der Waals
ARFORMOTEROL S211 5.42x43 TM5 polar (hydrogen bond with backbone)
ARFORMOTEROL S211 5.42x43 TM5 polar (hydrogen bond)
ARFORMOTEROL S211 5.42x43 TM5 polar (hydrogen bond)
ARFORMOTEROL S211 5.42x43 TM5 Van der Waals
ARFORMOTEROL S215 5.46x461 TM5 polar (hydrogen bond)
ARFORMOTEROL F306 6.51x51 TM6 aromatic (edge-to-face)
ARFORMOTEROL F306 6.51x51 TM6 Van der Waals
ARFORMOTEROL F307 6.52x52 TM6 Van der Waals
ARFORMOTEROL F307 6.52x52 TM6 aromatic (edge-to-face)
ARFORMOTEROL N310 6.55x55 TM6 Van der Waals
ARFORMOTEROL N310 6.55x55 TM6 polar (hydrogen bond)
ARFORMOTEROL F325 7.35x34 TM7 Van der Waals
ARFORMOTEROL F325 7.35x34 TM7 hydrophobic
ARFORMOTEROL N329 7.39x38 TM7 Van der Waals
ARFORMOTEROL N329 7.39x38 TM7 polar (hydrogen bond)
ARFORMOTEROL N329 7.39x38 TM7 polar (hydrogen bond)
ARFORMOTEROL Y333 7.43x42 TM7 Van der Waals
ARFORMOTEROL Y333 7.43x42 TM7 polar (hydrogen bond)

Ligands

ARFORMOTEROL

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Residue Diagrams

V N G A V I L L V V L A M L L S M G A E 1 T S L A C A D L V M G L L V V P F G A T L 2 V C L T E I S A T V C L V D L S T W C E 3 A K V I I C T V W A I S A L V S F L P I 4 Y V F I M I L L P I Y F S I I S S A I A Y 5 G I I M G V F T L C W L P F F L V N I V 6 I P N F A S N A Y G L W N F F V F L W 7
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ICL1 Q R L Q ICL1ECL1 T W L W ECL1ICL2 P F R Y Q S L M ICL2ECL2 W W R D E D P Q A L K C Y Q D P G C C D F V T ECL2ICL3 G R F Y G S Q E Q P Q P P P L P Q H Q P I L G N G R A S K ICL3ECL3 R D L V ECL3N-term M G D G W L P P D C G P H N R S G G G G A T A A P T G S R Q V S N-termC-term F P R K A D R R L H A G G Q P A P L P G G F I S T L G S P E H S P G G T W S D C N G G T R G G S E S S L E E R H S K T S R S E S K M E R E K N I L A T T R F Y C T F L G N G D K A V F C T V L R I V K L F E D A T C T C P H T H K L K M K W R F K Q H Q A C-term A E L L S Q Q W E A G M S L L M A L V V L L I V A G N V L V I A A I G R T T L T N L F I T S L A C A D L V M G L L V V P F G A T L V V R G G S F L C E C W T S L D V L C V T A S I E T L C V I A I D R Y L A I T S T R A R A K V I I C T V W A I S A L V S F L P I M M H N R A Y A I A S S I I S F Y I P L L I M I F V Y L R V Y R E A K E Q I R K I D R C E R K T S R V M A M R E H K A L K T L G I I M G V F T L C W L P F F L V N I V N V F N P D W L F V F F N W L G Y A N S A F N P I I Y C R S P D F K R F R K A L L C
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Residue Table


GPCRdb(A)
GPCRdb(A)
β1-adrenoceptor
TM3
3x28 3.28x28 W117
3x32 3.32x32 D121
3x33 3.33x33 V122
3x36 3.36x36 V125
ECL2
45x51 45.51x51 D200
45x52 45.52x52 F201
TM5
5x39 5.38x39 Y207
5x40 5.39x40 A208
5x43 5.42x43 S211
5x461 5.46x461 S215
TM6
6x51 6.51x51 F306
6x52 6.52x52 F307
6x55 6.55x55 N310
TM7
7x34 7.35x34 F325
7x38 7.39x38 N329
7x42 7.43x42 Y333