Structure information

α2B-adrenoceptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6K42

SPECIES

Homo sapiens

RESOLUTION

4.100

PREFERRED CHAIN

R

REFERENCE

10.1038/S41589-020-0492-2

PUBLICATION DATE

April 15, 2020

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
dexmedetomidine D92 3.32x32 TM3 polar (charge-assisted hydrogen bond)
dexmedetomidine V93 3.33x33 TM3 Van der Waals
dexmedetomidine V93 3.33x33 TM3 hydrophobic
dexmedetomidine C96 3.36x36 TM3 Van der Waals
dexmedetomidine C96 3.36x36 TM3 hydrophobic
dexmedetomidine S176 5.42x43 TM5 Van der Waals
dexmedetomidine S180 5.46x461 TM5 Van der Waals
dexmedetomidine W384 6.48x48 TM6 Van der Waals
dexmedetomidine F387 6.51x51 TM6 Van der Waals
dexmedetomidine F387 6.51x51 TM6 hydrophobic
dexmedetomidine F388 6.52x52 TM6 hydrophobic
dexmedetomidine F388 6.52x52 TM6 Van der Waals
dexmedetomidine Y391 6.55x55 TM6 hydrophobic
dexmedetomidine Y391 6.55x55 TM6 Van der Waals
dexmedetomidine F412 7.39x38 TM7 hydrophobic
dexmedetomidine F412 7.39x38 TM7 Van der Waals
dexmedetomidine G415 7.42x41 TM7 Van der Waals
dexmedetomidine Y416 7.43x42 TM7 Van der Waals
dexmedetomidine Y416 7.43x42 TM7 aromatic (face-to-edge)

Ligands

dexmedetomidine

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Residue Diagrams

A N G F I T F L I L F T I A A A I A A T 1 V S L A A A D I L V A L T I I P F S L A N 2 A C L H V I S S T C F L V D L A L Y V E 3 I K C I I L T V W L I A A V I S L P P L 4 Y V L I M I L C P A F F S G I S S A L I Y 5 A V V I G V F V L C W F P F F F S Y S L 6 V P N L S S N C Y G I W F F F Q F L G 7
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ICL1 R S L R ICL1ECL1 Y W Y F ECL1ICL2 A L E Y N S K R ICL2ECL2 Y K G D Q G P Q P R G R P Q C K L N Q ECL2ICL3 K G G P G Q G E S K Q P R P D H G G A L A S A K L P A L A S V A S A R E V N G H S K S T G E K E E G E T P E D T G T R A L P P S W A A L P N S G Q G Q K E G V C G A S P E D E A E E E E E E E E E E E E C E P Q A V P V S P A S A C S P P L Q Q P Q G S R V L A T L R G Q V L L G R G V G A I G G Q W W R R ICL3ECL3 P K H C K V ECL3N-term M D H Q D P Y S V Q N-termC-term R P W T Q T A W C-term A T A A I A A A I T F L I L F T I F G N A L V I L A V L T S A P Q N L F L V S L A A A D I L V A T L I I P F S L A N E L L G R R T W C E V Y L A L D V L F C T S S I V H L C A I S L D R Y W A V S R T P R R I K C I I L T V W L I A A V I S L P P L I E A W Y I L A S S I G S F F A P C L I M I L V Y L R I Y L I A K R S N R R G P R A R A Q L T R E K R F T F V L A V V I G V F V L C W F P F F F S Y S L G A I C P H G L F Q F F F W I G Y C N S S L N P V I Y T I F N Q D F R R F R R A I L C
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Residue Table


GPCRdb(A)
GPCRdb(A)
α2B-adrenoceptor
TM3
3x32 3.32x32 D92
3x33 3.33x33 V93
3x36 3.36x36 C96
TM5
5x43 5.42x43 S176
5x461 5.46x461 S180
TM6
6x48 6.48x48 W384
6x51 6.51x51 F387
6x52 6.52x52 F388
6x55 6.55x55 Y391
TM7
7x38 7.39x38 F412
7x41 7.42x41 G415
7x42 7.43x42 Y416