Structure information

α2A-adrenoceptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6KUX

SPECIES

Homo sapiens

RESOLUTION

2.700

PREFERRED CHAIN

A

REFERENCE

PUBLICATION DATE

Dec. 4, 2019

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
RS79948 Y109 3.28x28 TM3 hydrophobic
RS79948 D113 3.32x32 TM3 polar (charge-assisted hydrogen bond)
RS79948 V114 3.33x33 TM3 Van der Waals
RS79948 V114 3.33x33 TM3 hydrophobic
RS79948 C188 45.50x50 ECL2 Van der Waals
RS79948 E189 45.51x51 ECL2 Van der Waals
RS79948 I190 45.52x52 ECL2 Van der Waals
RS79948 I190 45.52x52 ECL2 hydrophobic
RS79948 S204 5.46x461 TM5 Van der Waals
RS79948 W387 6.48x48 TM6 hydrophobic
RS79948 W387 6.48x48 TM6 Van der Waals
RS79948 F390 6.51x51 TM6 aromatic (edge-to-face)
RS79948 F390 6.51x51 TM6 Van der Waals
RS79948 F391 6.52x52 TM6 hydrophobic
RS79948 F391 6.52x52 TM6 Van der Waals
RS79948 F412 7.39x38 TM7 hydrophobic
RS79948 F412 7.39x38 TM7 Van der Waals
RS79948 Y416 7.43x42 TM7 Van der Waals
RS79948 Y416 7.43x42 TM7 hydrophobic

Ligands

RS79948

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Residue Diagrams

V N G F V T L L M L L G A L C V L T L T 1 V S L A S A D I L V A L T V I P F S L A N 2 A C L H V I S S T C F L V D L A L Y I E 3 I K A I I I T V W V I S A V I S F P P L 4 Y V L I M I L C P A F F S G I C S S I V Y 5 A V V I G V F V V C W F P F F F T Y T L 6 V P N L S S N C Y G F W F F F K F L T 7
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ICL1 R A L K ICL1ECL1 Y W Y F ECL1ICL2 A I E Y N L K R ICL2ECL2 S I E K K G G G G G P Q P A E P R C E I N D ECL2ICL3 R G P D A V A A P P G G T E R R P N G L G P E R S A G P G G A E A E P L P T Q L N G A P G E P A P A G P R D T D A L D L E E S S S S D H A E R P P G P R R P E R G P R G K G K A R A S Q V K P G D S L P R R G P G A T G I G T P A A G P G E E R V G A A K A S R W ICL3ECL3 C S V ECL3N-term M F R Q E Q P L A E G S F A P M G S L Q P D A G N A S W N G T E A P G G G A R A T P Y S L N-termC-term G D R K R I V C-term Q V T L T L V C L A G L L M L L T V F G N V L V I I A V F T S A P Q N L F L V S L A S A D I L V A T L V I P F S L A N E V M G G K A W C E I Y L A L D V L F C T S S I V H L C A I S L D R Y W S I T Q T P R R I K A I I I T V W V I S A V I S F P P L I Q K W Y V I S S C I G S F F A P C L I M I L V Y V R I Y Q I A K R R T R V P P S R R G R Q N R E K R F T F V L A V V I G V F V V C W F P F F F T Y T L T A V G P R T L F K F F F W F G Y C N S S L N P V I Y T I F N H D F K K F R R A I L C R
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Residue Table


GPCRdb(A)
GPCRdb(A)
α2A-adrenoceptor
TM3
3x28 3.28x28 Y124
3x32 3.32x32 D128
3x33 3.33x33 V129
ECL2
45x50 45.50x50 C203
45x51 45.51x51 E204
45x52 45.52x52 I205
TM5
5x461 5.46x461 S219
TM6
6x48 6.48x48 W402
6x51 6.51x51 F405
6x52 6.52x52 F406
TM7
7x38 7.39x38 F427
7x42 7.43x42 Y431