Structure information

MT2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6ME7

SPECIES

Homo sapiens

RESOLUTION

3.200

PREFERRED CHAIN

A

REFERENCE

10.1038/S41586-019-1144-0

PUBLICATION DATE

April 24, 2019

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL15060 M120 3.32x32 TM3 hydrophobic
CHEMBL15060 V124 3.36x36 TM3 hydrophobic
CHEMBL15060 L172 4.57x57 TM4 hydrophobic
CHEMBL15060 N175 4.60x61 TM4 polar (hydrogen bond)
CHEMBL15060 N175 4.60x61 TM4 Van der Waals
CHEMBL15060 L181 ECL2 Van der Waals
CHEMBL15060 T191 45.51x51 ECL2 Van der Waals
CHEMBL15060 F192 45.52x52 ECL2 hydrophobic
CHEMBL15060 F192 45.52x52 ECL2 Van der Waals
CHEMBL15060 Q194 ECL2 Van der Waals
CHEMBL15060 Q194 ECL2 polar (hydrogen bond)
CHEMBL15060 Y200 5.38x39 TM5 Van der Waals
CHEMBL15060 V204 5.42x43 TM5 Van der Waals
CHEMBL15060 L267 6.51x51 TM6 hydrophobic
CHEMBL15060 L267 6.51x51 TM6 Van der Waals
CHEMBL15060 N268 6.52x52 TM6 Van der Waals
CHEMBL15060 Y294 7.39x38 TM7 Van der Waals
CHEMBL15060 Y294 7.39x38 TM7 aromatic (face-to-face)
CHEMBL15060 A297 7.42x41 TM7 hydrophobic
CHEMBL15060 A297 7.42x41 TM7 Van der Waals
CHEMBL15060 Y298 7.43x42 TM7 Van der Waals
CHEMBL15060 Y298 7.43x42 TM7 aromatic (edge-to-face)

Ligands

CHEMBL15060

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Residue Diagrams

L N G V V D V A T T V I L V A S L A P A 1 V S L A L A D L V V A Y F P Y P L I L V A 2 A T I N F V S G I V S L G M V F A S A K 3 T P L H I C L I W L L T V V A L L P N 4 Y C F S V V A I P L L F H I V V V A A T Y 5 F V V F V I F A I C W A P L N C I G L A 6 I A N L C S N F Y A L L Y S T V F L G 7
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ICL1 R K L R ICL1ECL1 G W A L ECL1ICL2 S M A Y H R I Y ICL2ECL2 S L E Y D P R I Y S C T F I Q T A ECL2ICL3 K P E S R ICL3ECL3 P Q E M A P Q I ECL3N-term M S E N G S F A N C C E A G G W A V R P G W S G A G S A R P S R T P R P P N-termC-term P R H C I Q D A S K G S H A E G L Q S P A P P I I G V Q H Q A D A L C-term W V A P A L S A V L I V T T A V D V V G N L L V I L S V L R N N A G N L F L V S L A L A D L V V A F Y P Y P L I L V A I F Y D G E E H C K A S A F V M G L S V I G S V F N I T A I A I N R Y C Y I C H R R W H T P L H I C L I W L L T V V A L L P N F F V G S T Q Y T A A V V V I H F L L P I A V V S F C Y L R I W V L V L Q A R R K A L C L K P S D L R S F L T M F V V F V I F A I C W A P L N C I G L A V A I N P E G L F V T S Y L L A Y F N S C L N A I V Y G L L N Q N Y K R L W N F R R E I L L A
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Residue Table


GPCRdb(A)
GPCRdb(A)
MT2 receptor
TM3
3x32 3.32x32 M120
3x36 3.36x36 V124
TM4
4x57 4.57x57 L172
4x61 4.60x61 N175
ECL2
45x51 45.51x51 T191
45x52 45.52x52 F192
TM5
5x39 5.38x39 Y200
5x43 5.42x43 V204
TM6
6x51 6.51x51 L267
6x52 6.52x52 N268
TM7
7x38 7.39x38 Y294
7x41 7.42x41 A297
7x42 7.43x42 Y298