Structure information

CRF1 receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

6PB0

SPECIES

Homo sapiens

RESOLUTION

3.000

PREFERRED CHAIN

R

REFERENCE

10.1016/J.MOLCEL.2020.01.013

PUBLICATION DATE

Feb. 12, 2020

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Urocortin E109 N-term polar (charge-assisted hydrogen bond)
Urocortin K113 1.33x33 TM1 polar (charge-assisted hydrogen bond)
Urocortin H117 1.37x37 TM1 Van der Waals
Urocortin V120 1.40x40 TM1 hydrophobic
Urocortin W169 2.64x64 TM2 Van der Waals
Urocortin W169 2.64x64 TM2 polar (hydrogen bond)
Urocortin Q173 2.68x68 TM2 Van der Waals
Urocortin P178 ECL1 Van der Waals
Urocortin P178 ECL1 hydrophobic
Urocortin H181 ECL1 Van der Waals
Urocortin T192 3.33x33 TM3 Van der Waals
Urocortin Y195 3.36x36 TM3 polar (hydrogen bond)
Urocortin N196 3.37x37 TM3 Van der Waals
Urocortin H199 3.40x40 TM3 Van der Waals
Urocortin F203 3.44x44 TM3 Van der Waals
Urocortin F203 3.44x44 TM3 hydrophobic
Urocortin F260 45.52x52 ECL2 polar (hydrogen bond with backbone)
Urocortin F260 45.52x52 ECL2 Van der Waals
Urocortin K262 ECL2 Van der Waals
Urocortin Y272 5.39x39 TM5 polar (hydrogen bond)
Urocortin Y272 5.39x39 TM5 Van der Waals
Urocortin Q273 5.40x40 TM5 Van der Waals
Urocortin M276 5.43x43 TM5 Van der Waals
Urocortin M276 5.43x43 TM5 hydrophobic
Urocortin Y327 6.53x53 TM6 Van der Waals
Urocortin Y327 6.53x53 TM6 hydrophobic
Urocortin F330 ECL3 Van der Waals
Urocortin F330 ECL3 polar (hydrogen bond with backbone)
Urocortin F331 ECL3 Van der Waals
Urocortin F331 ECL3 polar (hydrogen bond with backbone)
Urocortin F344 7.38x37 TM7 Van der Waals
Urocortin F344 7.38x37 TM7 hydrophobic
Urocortin I345 7.39x38 TM7 hydrophobic
Urocortin I345 7.39x38 TM7 Van der Waals
Urocortin N348 7.42x41 TM7 polar (hydrogen bond)
Urocortin N348 7.42x41 TM7 polar (hydrogen bond)
Urocortin S349 7.43x42 TM7 Van der Waals
Urocortin E352 7.46x45 TM7 polar (charge-assisted hydrogen bond)

Ligands

Urocortin

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Residue Diagrams

L L A V L S I C H G L Y N I I V A V H Y 1 W N L I S A F I L R N A T W F V V Q L T 2 G F M W F F N T V H F Y N Y A A T V L R 3 R K W M F I C G I W G V P F P I I V A W A 4 L F I F N I L L V L I M P G Q Y I Y D T 5 L V L L P L L G I T Y M L F F V 6 V S V F F G Q F S E L F S N F Y I F V 7
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ICL1 R S I R ICL1ECL1 M S P E V H Q S N ECL1ICL2 T Y S T D R ICL2ECL2 N E K C W F G K R P G V Y ECL2ICL3 R A S T T ICL3ECL3 N P G E D ECL3N-term M G G H P Q L R L V K A L L L L G L N P V S A S L Q D Q H C E S L S L A S N I S G L Q C N A S V D L I G T C W P R S P A G Q L V V R P C P A F F Y G V R Y N T T N N G Y R E C L A N G S W A A R V N Y S E C N-termC-term R A M S I P T S P T R V S F H S I K Q S T A V C-term Q E I L N E E K K S K V H Y H V A V I I N Y L G H C I S L V A L L V A F V L F L R L C L R N I I H W N L I S A F I L R N A T W F V V Q L T V G W C R L V T A A Y N Y F H V T N F F W M F G E G C Y L H T A I V L L R K W M F I C I G W G V P F P I I V A W A I G K L Y Y D T D Y I Y Q G P M I L V L L I N F I F L F N I V R I L M T K L S E T I Q Y R K A V K A T L V L L P L L G I T Y M L F F V E V S R V V F I Y F N S F L E S F Q G F F V S V F Y C F L N S E I R K W Q D R A R V R S A R W H R K H S I V A
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Residue Table


GPCRdb(A)
GPCRdb(B)
CRF1 receptor
TM1
1x29 1.33x33 K113
1x33 1.37x37 H117
1x36 1.40x40 V120
TM2
2x57 2.64x64 W169
2x61 2.68x68 Q173
TM3
3x29 3.33x33 T192
3x32 3.36x36 Y195
3x33 3.37x37 N196
3x36 3.40x40 H199
3x40 3.44x44 F203
ECL2
45x52 45.52x52 F260
TM5
5x43 5.39x39 Y272
5x44 5.40x40 Q273
5x47 5.43x43 M276
TM6
6x48 6.53x53 Y327
TM7
7x33 7.38x37 F344
7x34 7.39x38 I345
7x37 7.42x41 N348
7x38 7.43x42 S349
7x41 7.46x45 E352