Structure information

α1B-adrenoceptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7B6W

SPECIES

Homo sapiens

RESOLUTION

2.870

PREFERRED CHAIN

A

REFERENCE

10.1038/s41467-021-27911-3

PUBLICATION DATE

Jan. 12, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
(+)-cyclazosin C118 3.25x25 TM3 polar (hydrogen bond)
(+)-cyclazosin C118 3.25x25 TM3 polar (hydrogen bond with backbone)
(+)-cyclazosin W121 3.28x28 TM3 polar (hydrogen bond with backbone)
(+)-cyclazosin W121 3.28x28 TM3 polar (hydrogen bond)
(+)-cyclazosin A122 3.29x29 TM3 polar (hydrogen bond with backbone)
(+)-cyclazosin A122 3.29x29 TM3 polar (hydrogen bond)
(+)-cyclazosin D125 3.32x32 TM3 polar (charge-assisted hydrogen bond)
(+)-cyclazosin D125 3.32x32 TM3 polar (hydrogen bond with backbone)
(+)-cyclazosin V126 3.33x33 TM3 polar (hydrogen bond)
(+)-cyclazosin C129 3.36x36 TM3 polar (hydrogen bond)
(+)-cyclazosin V194 ECL2 polar (hydrogen bond with backbone)
(+)-cyclazosin V194 ECL2 Van der Waals
(+)-cyclazosin C195 45.50x50 ECL2 Van der Waals
(+)-cyclazosin C195 45.50x50 ECL2 polar (hydrogen bond with backbone)
(+)-cyclazosin G196 45.51x51 ECL2 polar (hydrogen bond with backbone)
(+)-cyclazosin G196 45.51x51 ECL2 polar (hydrogen bond)
(+)-cyclazosin V197 45.52x52 ECL2 polar (hydrogen bond with backbone)
(+)-cyclazosin V197 45.52x52 ECL2 polar (hydrogen bond)
(+)-cyclazosin Y203 5.38x39 TM5 polar (hydrogen bond)
(+)-cyclazosin S207 5.42x43 TM5 polar (hydrogen bond)
(+)-cyclazosin S208 5.43x44 TM5 Van der Waals
(+)-cyclazosin S211 5.46x461 TM5 Van der Waals
(+)-cyclazosin W307 6.48x48 TM6 hydrophobic
(+)-cyclazosin W307 6.48x48 TM6 Van der Waals
(+)-cyclazosin F310 6.51x51 TM6 polar (hydrogen bond)
(+)-cyclazosin F311 6.52x52 TM6 polar (hydrogen bond)
(+)-cyclazosin L314 6.55x55 TM6 Van der Waals
(+)-cyclazosin D327 7.32x31 TM7 Van der Waals
(+)-cyclazosin D327 7.32x31 TM7 polar (hydrogen bond with backbone)
(+)-cyclazosin F330 7.35x34 TM7 Van der Waals
(+)-cyclazosin K331 7.36x35 TM7 Van der Waals
(+)-cyclazosin L334 7.39x38 TM7 polar (hydrogen bond)
(+)-cyclazosin Y338 7.43x42 TM7 polar (hydrogen bond)

Ligands

(+)-cyclazosin

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Residue Diagrams

I N G V I A F L I F A G L V L G V S I A 1 V N L A M A D L L L S T F V L P F S A A L 2 A C L S L I S A T C C L V D V A A W I D 3 A I L A L L S V W V L S T V I S I G P L 4 Y M V L I V A L P I Y F S G L S S F L A Y 5 G I V V G M F I L C W L P F F I A L P L 6 I P N L C S N F Y G L W F V V K F V A 7
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ICL1 R H L R ICL1ECL1 Y W V L ECL1ICL2 S L Q Y P T L V ICL2ECL2 K E P A P N D D K E C G V T E ECL2ICL3 G V M K E M S N S K E L T L R I H S K N F H E D T L S S T K A K G H N P R S S I A V K ICL3ECL3 S T L K P ECL3N-term M N P D L D T G H N T S A P A H W G E L K N A N F T G P N Q T S S N S T L P N-termC-term C Q C R G R G R R R R R R R R R L G G C A Y T Y R P W T R G G S L E R S Q S R K D S L D D S G S C L S G S Q R T L P S A S P S P G Y L G R G A P P P V E L C A F P E W K A P G A L L S L P A P E P P G R R G R H D S G P L F T F K L L T E P E S P G T D G G A S N G G C E A A A D V A N G Q P G F K S N M P L A P G Q F C-term Q L D I T R A I S V G L V L G A F I L F A I V G N I L V I L S V A C N T P T N Y F I V N L A M A D L L L S F T V L P F S A A L E V L G G R I F C D I W A A V D V L C C T A S I L S L C A I S I D R Y I G V R Y T R R K A I L A L L S V W V L S T V I S I G P L L G W E P F Y A L F S S L G S F Y I P L A V I L V M Y C R V Y I V A K R T T K N L E A L F K F S R E K K A A K T L G I V V G M F I L C W L P F F I A L P L G S L F P D A V F K V V F W L G Y F N S C L N P I I Y P C S S K E F V R F K R A I L G
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Residue Table


GPCRdb(A)
GPCRdb(A)
α1B-adrenoceptor
TM3
3x25 3.25x25 C118
3x28 3.28x28 W121
3x29 3.29x29 A122
3x32 3.32x32 D125
3x33 3.33x33 V126
3x36 3.36x36 C129
ECL2
45x50 45.50x50 C195
45x51 45.51x51 G196
45x52 45.52x52 V197
TM5
5x39 5.38x39 Y203
5x43 5.42x43 S207
5x44 5.43x44 S208
5x461 5.46x461 S211
TM6
6x48 6.48x48 W307
6x51 6.51x51 F310
6x52 6.52x52 F311
6x55 6.55x55 L314
TM7
7x31 7.32x31 D327
7x34 7.35x34 F330
7x35 7.36x35 K331
7x38 7.39x38 F334
7x42 7.43x42 Y338