Structure information

GnRH1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7BR3

SPECIES

Homo sapiens

RESOLUTION

2.790

PREFERRED CHAIN

A

REFERENCE

10.1038/S41467-020-19109-W

PUBLICATION DATE

Oct. 7, 2020

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
elagolix I21 N-term hydrophobic
elagolix P22 N-term Van der Waals
elagolix P22 N-term polar (hydrogen bond with backbone)
elagolix L23 N-term Van der Waals
elagolix L23 N-term hydrophobic
elagolix Q25 N-term Van der Waals
elagolix G26 N-term Van der Waals
elagolix D98 2.61x60 TM2 polar (hydrogen bond with backbone)
elagolix D98 2.61x60 TM2 Van der Waals
elagolix N102 2.65x64 TM2 Van der Waals
elagolix I103 ECL1 Van der Waals
elagolix K121 3.32x32 TM3 polar (charge-assisted hydrogen bond)
elagolix F216 5.43x44 TM5 Van der Waals
elagolix F216 5.43x44 TM5 hydrophobic
elagolix L219 5.46x461 TM5 Van der Waals
elagolix Y283 6.51x51 TM6 polar (hydrogen bond)
elagolix Y284 6.52x52 TM6 aromatic (edge-to-face)
elagolix Y284 6.52x52 TM6 Van der Waals
elagolix L286 6.54x54 TM6 hydrophobic
elagolix L286 6.54x54 TM6 Van der Waals
elagolix G287 6.55x55 TM6 Van der Waals
elagolix Y290 6.58x58 TM6 aromatic (face-to-edge)
elagolix M296 ECL3 Van der Waals
elagolix L297 ECL3 hydrophobic
elagolix L297 ECL3 Van der Waals
elagolix N305 7.35x34 TM7 polar (hydrogen bond with backbone)
elagolix N305 7.35x34 TM7 Van der Waals
elagolix F308 7.38x37 TM7 Van der Waals

Ligands

elagolix

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Residue Diagrams

A N F T A S L L F L F F T V T V R I K G 1 K H L T L A N L L E T I L V M P L D G M W 2 V V M M F A P A Y M S F L K L Y S L V K 3 G Q S M V G L A W I L S S V F A G P Q 4 N C I L M I F L P I I F L C S F T F F N Y 5 V A F A T S F T V C W T P Y Y V L G I W 6 L P D F C P N L F A F L F F F H N V P 7
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ICL1 K T Q K K E K G K L S ICL1ECL1 I T V Q W Y A ECL1ICL2 P L A L K S ICL2ECL2 R M I H L A D S S G Q T K V F S Q C V T H C S F S ECL2ICL3 E L Q L N ICL3ECL3 P E M L N R L ECL3N-term M A N S A S P E Q N Q N H C S A I N N S I P L M Q G N L P T L N-termC-term L C-term T L S G K I R V T V T F F L F L L S A T F N A S F L L K L Q K W R M K L L L K H L T L A N L L E T L I V M P L D G M W N G E L L C K V L S Y L K L F S M Y A P A F M M V V I S L D R S L A I T R N S K V G Q S M V G L A W I L S S V F A G P Q L Y I F Q W W H Q A F Y N F F T F S C L F I I P L F I M L I C N A K I I F T L T R V L H Q D P H Q S K N N I P R A R L K T L K M T V A F A T S F T V C W T P Y Y V L G I W Y W F D S D P V N H F F F L F A F L N P C F D P L I Y G Y F S
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Residue Table


GPCRdb(A)
GPCRdb(A)
GnRH1 receptor
TM2
2x60 2.61x60 D98
2x64 2.65x64 N102
TM3
3x32 3.32x32 K121
TM5
5x44 5.43x44 F216
5x461 5.46x461 L219
TM6
6x51 6.51x51 Y283
6x52 6.52x52 Y284
6x54 6.54x54 L286
6x55 6.55x55 G287
6x58 6.58x58 Y290
TM7
7x34 7.35x34 N305
7x37 7.38x37 F308