Structure information

β2-adrenoceptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7BZ2

SPECIES

Homo sapiens

RESOLUTION

3.820

PREFERRED CHAIN

R

REFERENCE

10.1038/S41421-020-0176-9

PUBLICATION DATE

Aug. 5, 2020

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
ARFORMOTEROL H93 2.64x63 TM2 aromatic (face-to-edge)
ARFORMOTEROL W109 3.28x28 TM3 hydrophobic
ARFORMOTEROL V114 3.33x33 TM3 hydrophobic
ARFORMOTEROL V117 3.36x36 TM3 hydrophobic
ARFORMOTEROL F193 45.52x52 ECL2 hydrophobic
ARFORMOTEROL S203 5.42x43 TM5 polar (hydrogen bond)
ARFORMOTEROL S203 5.42x43 TM5 polar (hydrogen bond)
ARFORMOTEROL S207 5.46x461 TM5 Van der Waals
ARFORMOTEROL F289 6.51x51 TM6 hydrophobic
ARFORMOTEROL F290 6.52x52 TM6 hydrophobic
ARFORMOTEROL F290 6.52x52 TM6 Van der Waals
ARFORMOTEROL Y308 7.35x34 TM7 hydrophobic
ARFORMOTEROL Y308 7.35x34 TM7 Van der Waals
ARFORMOTEROL N312 7.39x38 TM7 Van der Waals
ARFORMOTEROL Y316 7.43x42 TM7 polar (hydrogen bond)
ARFORMOTEROL Y316 7.43x42 TM7 polar (hydrogen bond)

Ligands

ARFORMOTEROL

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Residue Diagrams

V N G F V I A L V I L S M V I G M G V V 1 T S L A C A D L V M G A L V V P F G A A H 2 V C L T E I S A T V C L V D I S T W F E 3 A R V I I L M V W I V S G L T S F L P I 4 Y V F V M I V L P V Y F S V I S S A I A Y 5 G I I M G T F T L C W L P F F I V N I V 6 L P N F G S N V Y G I W N L L I Y V E 7
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ICL1 E R L Q ICL1ECL1 M W T F ECL1ICL2 P F K Y Q S L L ICL2ECL2 W Y R A T H Q E A I N C Y A N E T C C D F F T ECL2ICL3 G R F H V Q N L S Q V E Q D G R T G H G L R R S ICL3ECL3 D N L I ECL3N-term M G Q P G N G S A F L L A P N G S H A P D H D V T N-termC-term L R R S S L K A Y G N G Y S S N G N T G E Q S G Y H V E Q E K E N K L L C E D L P G T E D F V G H Q G T V P S D N I D S Q G R N C S T N D S L L C-term Q E R D E V W V V G M G I V M S L I V L A I V F G N V L V I T A I A K F T V T N Y F I T S L A C A D L V M G L A V V P F G A A H I L M K G N F W C E F W T S I D V L C V T A S I E T L C V I A V D R Y F A I T S T K N K A R V I I L M V W I V S G L T S F L P I Q M H N Q A Y A I A S S I V S F Y V P L V I M V F V Y S R V F Q E A K R Q L Q K I D K S E S K F C L K E H K A L K T L G I I M G T F T L C W L P F F I V N I V H V I Q R K E V Y I L L N W I G Y V N S G F N P L I Y C R S P D F Q E F R I A L L C
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Residue Table


GPCRdb(A)
GPCRdb(A)
β2-adrenoceptor
TM2
2x63 2.64x63 H93
TM3
3x28 3.28x28 W109
3x33 3.33x33 V114
3x36 3.36x36 V117
ECL2
45x52 45.52x52 F193
TM5
5x43 5.42x43 S203
5x461 5.46x461 S207
TM6
6x51 6.51x51 F289
6x52 6.52x52 F290
TM7
7x34 7.35x34 Y308
7x38 7.39x38 N312
7x42 7.43x42 Y316