Structure information

S1P3 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7C4S

SPECIES

Homo sapiens

RESOLUTION

3.200

PREFERRED CHAIN

A

REFERENCE

10.1126/SCIADV.ABF5325

PUBLICATION DATE

June 9, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
sphingosine 1-phosphate Y22 N-term polar (hydrogen bond)
sphingosine 1-phosphate E37 N-term polar (charge-assisted hydrogen bond)
sphingosine 1-phosphate N95 2.60x60 TM2 polar (hydrogen bond)
sphingosine 1-phosphate N95 2.60x60 TM2 Van der Waals
sphingosine 1-phosphate S99 2.64x64 TM2 polar (hydrogen bond)
sphingosine 1-phosphate S99 2.64x64 TM2 Van der Waals
sphingosine 1-phosphate G100 23.47x47 ECL1 polar (hydrogen bond with backbone)
sphingosine 1-phosphate G100 23.47x47 ECL1 Van der Waals
sphingosine 1-phosphate T103 23.50x50 ECL1 Van der Waals
sphingosine 1-phosphate R114 3.28x28 TM3 polar (charge-assisted hydrogen bond)
sphingosine 1-phosphate E115 3.29x29 TM3 polar (charge-assisted hydrogen bond)
sphingosine 1-phosphate M118 3.32x32 TM3 hydrophobic
sphingosine 1-phosphate M118 3.32x32 TM3 Van der Waals
sphingosine 1-phosphate F119 3.33x33 TM3 Van der Waals
sphingosine 1-phosphate F119 3.33x33 TM3 hydrophobic
sphingosine 1-phosphate L122 3.36x36 TM3 hydrophobic
sphingosine 1-phosphate L122 3.36x36 TM3 Van der Waals
sphingosine 1-phosphate L168 4.56x56 TM4 Van der Waals
sphingosine 1-phosphate L168 4.56x56 TM4 hydrophobic
sphingosine 1-phosphate I203 5.46x46 TM5 Van der Waals
sphingosine 1-phosphate W256 6.48x48 TM6 hydrophobic
sphingosine 1-phosphate W256 6.48x48 TM6 Van der Waals
sphingosine 1-phosphate F260 6.52x52 TM6 hydrophobic
sphingosine 1-phosphate I284 7.39x38 TM7 hydrophobic
sphingosine 1-phosphate I284 7.39x38 TM7 Van der Waals

Ligands

sphingosine 1-phosphate

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Residue Diagrams

L N E L V I F S C I V L F L V T T L T S 1 G N L A L C D L L A G I A Y K V N I L M 2 A L L S C T S A G L A V F M S G E R L F 3 V F L L I G M C W L I A F T L G A L P I 4 Y L I V I T V L I A T F I S I C F A I Y 5 V I V V S V F I A C W S P L F I L F L I 6 V P N M A S N L V A L V I F W Q A K F 7
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ICL1 N K F H ICL1ECL1 G K K T F S L ECL1ICL2 M R P Y D A N ICL2ECL2 W N C L H N L P D C S T I L P L Y ECL2ICL3 V A ICL3ECL3 R V Q A C ECL3N-term M A T A L P P R L Q P V R G N E T L R E H Y Q Y V G K L A G R L K E A S E G N-termC-term N C L V R G R G A R A S P I Q P A L D P S R S K S S S S N N S S H S P K V K E D L P H T A P S S C I M D K N A A L Q N G I F C N C-term S T L T T V L F L V I C S F I V L E N L M V L I A I W K N N R M Y F F I G N L A L C D L L A G I A Y K V N I L M S S P T V W F L R E G S M F V A L G A S T C S L L A I A I E R H L T M I K K R H R V F L L I G M C W L I A F T L G A L P I L G S K K Y I A F C I S I F T A I L V T I V I L Y A R I Y F L V K S S S R K N H N N S E R S M A L L R T V V I V V S V F I A C W S P L F I L F L I D V A C P I L F K A Q W F I V L A V L N S A M N P V I Y T L A S K E F F R M R R A L V C
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Residue Table


GPCRdb(A)
GPCRdb(A)
S1P3 receptor
TM2
2x60 2.60x60 N95
2x64 2.64x64 S99
ECL1
23x47 23.47x47 G100
23x50 23.50x50 T103
TM3
3x28 3.28x28 R114
3x29 3.29x29 E115
3x32 3.32x32 M118
3x33 3.33x33 F119
3x36 3.36x36 L122
TM4
4x56 4.56x56 L168
TM5
5x46 5.46x46 I203
TM6
6x48 6.48x48 W256
6x52 6.52x52 F260
TM7
7x38 7.39x38 I284