Structure information

D3 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7CMU

SPECIES

Homo sapiens

RESOLUTION

3.000

PREFERRED CHAIN

R

REFERENCE

10.1016/J.MOLCEL.2021.01.003

PUBLICATION DATE

March 10, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
pramipexole D110 3.32x32 TM3 polar (charge-assisted hydrogen bond)
pramipexole V111 3.33x33 TM3 hydrophobic
pramipexole V111 3.33x33 TM3 Van der Waals
pramipexole C114 3.36x36 TM3 Van der Waals
pramipexole S192 5.42x43 TM5 polar (hydrogen bond with backbone)
pramipexole S192 5.42x43 TM5 Van der Waals
pramipexole S196 5.46x461 TM5 Van der Waals
pramipexole F345 6.51x51 TM6 hydrophobic
pramipexole F345 6.51x51 TM6 Van der Waals
pramipexole F346 6.52x52 TM6 aromatic (edge-to-face)
pramipexole F346 6.52x52 TM6 Van der Waals
pramipexole H349 6.55x55 TM6 Van der Waals
pramipexole T369 7.39x38 TM7 Van der Waals
pramipexole Y373 7.43x42 TM7 hydrophobic
pramipexole Y373 7.43x42 TM7 Van der Waals

Ligands

pramipexole

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Residue Diagrams

G N G F V I A L I L A C Y S L A Y Y A H 1 V S L A V A D L L V A L T V M P W V V Y L 2 A C L N L I S A T C M M V D L T V F V D 3 V A L M I T A V W V L A F A V S C P L 4 Y V L V T V G F P L Y F S V V S S Y I V F 5 A I V L G A F I V C W L P F F L T H V L 6 V P N L A S N V Y G L W T T A S Y L E 7
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ICL1 R A L Q ICL1ECL1 G V W N F ECL1ICL2 P V H Y Q H G T G Q S ICL2ECL2 F N T T G D P T V C S I S ECL2ICL3 Q N S Q C N S V R P G F P Q Q T L S P D P A H L E L K R Y Y S I C Q D T A L G G P G F Q E R G G E L K R E E K T R N S L S P T I A P K L S L E V R K L S N G R L S T S L K L G P L Q P ICL3ECL3 Q T C H V ECL3N-term M A S L S Q L S G H L N Y T C G A E N S T G A S Q N-termC-term C C-term A R P H A Y Y A L S Y C A L I L A I V F G N G L V C M A V L K E T T T N Y L V V S L A V A D L L V A T L V M P W V V Y L E V T G S R I C C D V F V T L D V M M C T A S I L N L C A I S I D R Y T A V V M S C R R V A L M I T A V W V L A F A V S C P L L F G N P D F V I Y S S V V S F Y L P F G V T V L V Y A R I Y V V L K Q R R R K R I L T R R G V P L R E K K A T Q M V A I V L G A F I V C W L P F F L T H V L N T H C S P E L Y S A T T W L G Y V N S A L N P V I Y T T F N I E F L K F R K A I L S
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Residue Table


GPCRdb(A)
GPCRdb(A)
D3 receptor
TM3
3x32 3.32x32 D110
3x33 3.33x33 V111
3x36 3.36x36 C114
TM5
5x43 5.42x43 S192
5x461 5.46x461 S196
TM6
6x51 6.51x51 F345
6x52 6.52x52 F346
6x55 6.55x55 H349
TM7
7x38 7.39x38 T369
7x42 7.43x42 Y373