Structure information

D2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7DFP

SPECIES

Homo sapiens

RESOLUTION

3.100

PREFERRED CHAIN

A

REFERENCE

10.1038/S41467-020-20221-0

PUBLICATION DATE

Dec. 30, 2020

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
spiperone W90 2.60x59 TM2 hydrophobic
spiperone V91 2.61x60 TM2 hydrophobic
spiperone L94 2.64x63 TM2 hydrophobic
spiperone F110 3.28x28 TM3 hydrophobic
spiperone V111 3.29x29 TM3 hydrophobic
spiperone D114 3.32x32 TM3 polar (charge-assisted hydrogen bond)
spiperone V115 3.33x33 TM3 Van der Waals
spiperone C118 3.36x36 TM3 Van der Waals
spiperone C118 3.36x36 TM3 hydrophobic
spiperone I122 3.40x40 TM3 Van der Waals
spiperone C182 45.50x50 ECL2 Van der Waals
spiperone I184 45.52x52 ECL2 Van der Waals
spiperone F198 5.47x47 TM5 Van der Waals
spiperone F382 6.44x44 TM6 Van der Waals
spiperone W386 6.48x48 TM6 aromatic (face-to-edge)
spiperone W386 6.48x48 TM6 Van der Waals
spiperone F389 6.51x51 TM6 Van der Waals
spiperone F389 6.51x51 TM6 hydrophobic
spiperone F390 6.52x52 TM6 aromatic (edge-to-face)
spiperone F390 6.52x52 TM6 Van der Waals
spiperone T412 7.39x38 TM7 Van der Waals
spiperone Y416 7.43x42 TM7 Van der Waals

Ligands

spiperone

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Residue Diagrams

V N G F V I V A I L L T L L T A Y Y N Y 1 V S L A V A D L L V A L T V M P W V V Y L 2 A C L N L I S A T C M M V D L T V F I D 3 V T V M I S I V W V L S F T I S C P L 4 Y V L L T V I F P V Y F S V I S S Y V V F 5 A I V L G V F I I C W L P F F I T H I L 6 I P N V A S N V Y G L W T F A S Y L V 7
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ICL1 K A L Q ICL1ECL1 E W K F ECL1ICL2 P M L Y N ICL2ECL2 L N N A D Q N E C I I A ECL2ICL3 R S S R A F R A H L R A P L K G N C T H P E D M K L C T V I M K S N G S F P V N R R R V E A A R R A Q E L E M E M L S S T S P P E R T R Y S P I P P S H H Q L T L P D P S H H G L H S T P D S P A K P E K N G H A K D H P K I A K I F E I Q T M P N G K T R T S L K T M S R R ICL3ECL3 D C N I ECL3N-term M D P L N L S W Y D D D L E R Q N W S R P F N G S D G K A D N-termC-term C C-term R P H Y N Y Y A T L L T L L I A V I V F G N V L V C M A V S R E T T T N Y L I V S L A V A D L L V A T L V M P W V V Y L E V V G S R I H C D I F V T L D V M M C T A S I L N L C A I S I D R Y T A V A M T R Y S S K R R V T V M I S I V W V L S F T I S C P L L F G N P A F V V Y S S I V S F Y V P F I V T L L V Y I K I Y I V L R R R R K R V N T K K L S Q Q K E K K A T Q M L A I V L G V F I I C W L P F F I T H I L N I H C P P V L Y S A F T W L G Y V N S A V N P I I Y T T F N I E F L K F R K A I L H
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Residue Table


GPCRdb(A)
GPCRdb(A)
D2 receptor
TM2
2x59 2.60x59 W90
2x60 2.61x60 V91
2x63 2.64x63 L94
TM3
3x28 3.28x28 F110
3x29 3.29x29 V111
3x32 3.32x32 D114
3x33 3.33x33 V115
3x36 3.36x36 C118
3x40 3.40x40 I122
ECL2
45x50 45.50x50 C182
45x52 45.52x52 I184
TM5
5x47 5.47x47 F198
TM6
6x44 6.44x44 F382
6x48 6.48x48 W386
6x51 6.51x51 F389
6x52 6.52x52 F390
TM7
7x38 7.39x38 T412
7x42 7.43x42 Y416