Structure information

V2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7DW9

SPECIES

Homo sapiens

RESOLUTION

2.600

PREFERRED CHAIN

R

REFERENCE

10.1038/S41422-021-00480-2

PUBLICATION DATE

July 21, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
vasopressin D33 1.28x28 TM1 polar (charge-assisted hydrogen bond)
vasopressin L36 1.31x31 TM1 hydrophobic
vasopressin L36 1.31x31 TM1 Van der Waals
vasopressin A37 1.32x32 TM1 Van der Waals
vasopressin E40 1.35x35 TM1 polar (charge-assisted hydrogen bond)
vasopressin Q92 2.57x56 TM2 Van der Waals
vasopressin Q96 2.61x60 TM2 polar (hydrogen bond)
vasopressin Q96 2.61x60 TM2 Van der Waals
vasopressin D103 ECL1 Van der Waals
vasopressin D103 ECL1 polar (hydrogen bond with backbone)
vasopressin R104 23.49x49 ECL1 polar (charge-assisted hydrogen bond)
vasopressin K116 3.29x29 TM3 polar (charge-assisted hydrogen bond)
vasopressin Q119 3.32x32 TM3 Van der Waals
vasopressin M120 3.33x33 TM3 Van der Waals
vasopressin M123 3.36x36 TM3 hydrophobic
vasopressin M123 3.36x36 TM3 Van der Waals
vasopressin Q174 4.60x61 TM4 polar (hydrogen bond)
vasopressin Q174 4.60x61 TM4 Van der Waals
vasopressin F178 4.64x65 TM4 Van der Waals
vasopressin F178 4.64x65 TM4 hydrophobic
vasopressin W193 45.51x51 ECL2 polar (hydrogen bond)
vasopressin A194 45.52x52 ECL2 Van der Waals
vasopressin A194 45.52x52 ECL2 polar (hydrogen bond with backbone)
vasopressin R202 5.35x36 TM5 polar (charge-assisted hydrogen bond)
vasopressin Y205 5.38x39 TM5 Van der Waals
vasopressin V206 5.39x40 TM5 Van der Waals
vasopressin V206 5.39x40 TM5 hydrophobic
vasopressin I209 5.42x43 TM5 Van der Waals
vasopressin I209 5.42x43 TM5 hydrophobic
vasopressin F287 6.51x51 TM6 Van der Waals
vasopressin F287 6.51x51 TM6 hydrophobic
vasopressin Q291 6.55x55 TM6 polar (hydrogen bond)
vasopressin Q291 6.55x55 TM6 Van der Waals
vasopressin A295 6.59x59 TM6 Van der Waals
vasopressin L302 ECL3 hydrophobic
vasopressin L302 ECL3 Van der Waals
vasopressin V308 7.36x35 TM7 hydrophobic
vasopressin V308 7.36x35 TM7 Van der Waals
vasopressin M311 7.39x38 TM7 Van der Waals
vasopressin L312 7.40x39 TM7 polar (hydrogen bond with backbone)
vasopressin L312 7.40x39 TM7 Van der Waals

Ligands

vasopressin

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Residue Diagrams

G N S L A V A V F V I S L L A L E A R A 1 G H L C L A D L A V A F L Q V L P Q L A W 2 A L I M Y S S A Y M G V M Q L Y K V A R 3 W N R P V L V A W A F S L L L S L P Q 4 Q C A A I G L T P A V F V M L A I W T V Y 5 L V I V V V Y V L C W A P F F L V Q L W 6 W P N T C S N L S A L L M L L V F P A 7
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ICL1 H W ICL1ECL1 R F R G ECL1ICL2 P M L A Y R H G ICL2ECL2 A Q R N V E G G S G V T D C W A C F A E P ECL2ICL3 P G G R R R G R R T G S P G E G ICL3ECL3 P E A P L E ECL3N-term M L M A S T T S A V P G H P S L P S L P S N S S Q E R P L D T R N-termC-term R T P P S L G P Q D E S C T T A S S S L A K D T S S C-term D P L L A R A E L A L L S I V F V A V A L S N G L V L A A L A R R G R R G A P I H V F I G H L C L A D L A V A L F Q V L P Q L A W K A T D P D A L C R A V K Y L Q M V G M Y A S S Y M I L A M T L D R H R A I C R S G A H W N R P V L V A W A F S L L L S L P Q L F I F W G R R T Y V T W I A L M V F V A P T L G I A A C Q V L I F R E I H A S L V P G P S E R A H V S A A V A K T V R M T L V I V V V Y V L C W A P F F L V Q L W A A W D G A P F V L L M L L A S L N S C T N P W I Y A S F S S S L R S A R G V S S E L L C C
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Residue Table


GPCRdb(A)
GPCRdb(A)
V2 receptor
TM1
1x28 1.28x28 D33
1x31 1.31x31 L36
1x32 1.32x32 A37
1x35 1.35x35 E40
TM2
2x56 2.57x56 Q92
2x60 2.61x60 Q96
ECL1
23x49 23.49x49 R104
TM3
3x29 3.29x29 K116
3x32 3.32x32 Q119
3x33 3.33x33 M120
3x36 3.36x36 M123
TM4
4x61 4.60x61 Q174
4x65 4.64x65 F178
ECL2
45x51 45.51x51 W193
45x52 45.52x52 A194
TM5
5x36 5.35x36 R202
5x39 5.38x39 Y205
5x40 5.39x40 V206
5x43 5.42x43 I209
TM6
6x51 6.51x51 F287
6x55 6.55x55 Q291
6x59 6.59x59 A295
TM7
7x35 7.36x35 V308
7x38 7.39x38 M311
7x39 7.40x39 L312