Structure information

B1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7EIB

SPECIES

Homo sapiens

RESOLUTION

3.000

PREFERRED CHAIN

A

REFERENCE

10.1038/S41594-021-00645-Y

PUBLICATION DATE

Oct. 13, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
[des-Arg<sup>10</sup>]kallidin W33 1.28x28 TM1 polar (hydrogen bond)
[des-Arg<sup>10</sup>]kallidin F86 2.53x53 TM2 hydrophobic
[des-Arg<sup>10</sup>]kallidin F86 2.53x53 TM2 Van der Waals
[des-Arg<sup>10</sup>]kallidin W93 2.60x60 TM2 Van der Waals
[des-Arg<sup>10</sup>]kallidin W93 2.60x60 TM2 hydrophobic
[des-Arg<sup>10</sup>]kallidin F101 ECL1 Van der Waals
[des-Arg<sup>10</sup>]kallidin F101 ECL1 hydrophobic
[des-Arg<sup>10</sup>]kallidin N114 3.29x29 TM3 Van der Waals
[des-Arg<sup>10</sup>]kallidin I117 3.32x32 TM3 Van der Waals
[des-Arg<sup>10</sup>]kallidin I117 3.32x32 TM3 hydrophobic
[des-Arg<sup>10</sup>]kallidin K118 3.33x33 TM3 polar (charge-assisted hydrogen bond)
[des-Arg<sup>10</sup>]kallidin L121 3.36x36 TM3 Van der Waals
[des-Arg<sup>10</sup>]kallidin L121 3.36x36 TM3 hydrophobic
[des-Arg<sup>10</sup>]kallidin R176 4.64x65 TM4 polar (charge-assisted hydrogen bond)
[des-Arg<sup>10</sup>]kallidin V181 ECL2 hydrophobic
[des-Arg<sup>10</sup>]kallidin V181 ECL2 Van der Waals
[des-Arg<sup>10</sup>]kallidin L184 ECL2 hydrophobic
[des-Arg<sup>10</sup>]kallidin L184 ECL2 Van der Waals
[des-Arg<sup>10</sup>]kallidin C189 45.50x50 ECL2 polar (hydrogen bond with backbone)
[des-Arg<sup>10</sup>]kallidin C189 45.50x50 ECL2 Van der Waals
[des-Arg<sup>10</sup>]kallidin I190 45.51x51 ECL2 hydrophobic
[des-Arg<sup>10</sup>]kallidin I190 45.51x51 ECL2 Van der Waals
[des-Arg<sup>10</sup>]kallidin L191 45.52x52 ECL2 Van der Waals
[des-Arg<sup>10</sup>]kallidin L191 45.52x52 ECL2 polar (hydrogen bond with backbone)
[des-Arg<sup>10</sup>]kallidin R202 5.38x39 TM5 polar (charge-assisted hydrogen bond)
[des-Arg<sup>10</sup>]kallidin Y266 6.51x51 TM6 Van der Waals
[des-Arg<sup>10</sup>]kallidin Y266 6.51x51 TM6 polar (hydrogen bond)
[des-Arg<sup>10</sup>]kallidin E273 6.58x58 TM6 polar (charge-assisted hydrogen bond)
[des-Arg<sup>10</sup>]kallidin F276 6.61x61 TM6 hydrophobic
[des-Arg<sup>10</sup>]kallidin F276 6.61x61 TM6 Van der Waals
[des-Arg<sup>10</sup>]kallidin E287 7.28x27 TM7 polar (charge-assisted hydrogen bond)
[des-Arg<sup>10</sup>]kallidin D291 7.32x31 TM7 polar (charge-assisted hydrogen bond)
[des-Arg<sup>10</sup>]kallidin Q295 7.36x35 TM7 Van der Waals
[des-Arg<sup>10</sup>]kallidin N298 7.39x38 TM7 polar (hydrogen bond)
[des-Arg<sup>10</sup>]kallidin F299 7.40x39 TM7 hydrophobic
[des-Arg<sup>10</sup>]kallidin F299 7.40x39 TM7 Van der Waals
[des-Arg<sup>10</sup>]kallidin F302 7.43x42 TM7 Van der Waals
[des-Arg<sup>10</sup>]kallidin F302 7.43x42 TM7 hydrophobic

Ligands

[des-Arg<sup>10</sup>]kallidin

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Residue Diagrams

L N G L L G F F C I S I I F T P L V R H 1 A N L A A S D L V F V L G L P F W A E N 2 A V V L F I S I F L N A K I V G N I V R 3 A R V T C V L I W V V G G L L S I P T 4 N F F V I A A L P L L F G L I N L E V I R 5 L T L V V A F L V C W A P Y H F F A F L 6 V P N L S S N T F A F F N A L Q L G L 7
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ICL1 R R Q L ICL1ECL1 F N W P F ECL1ICL2 P M A S R R Q ICL2ECL2 S I Q A V P D L N I T A C I L L L P ECL2ICL3 C G G R K D ICL3ECL3 A V R ECL3N-term M A S S W P P L E L Q S S N Q S Q L F P Q N A T A C D N A N-termC-term Q C T P K S L A P I S S S H R K E I F Q L F W R N C-term P E A W D L L H R V L P T F I I S I C F F G L L G N L F V L L V F L L P N V A E I Y L A N L A A S D L V F V L G L P F W A E N I W N Q G A L L C R V I N G V I K A N L F I S I F L V V A I S Q D R Y R V L V H Q R R R Q A R V T C V L I W V V G G L L S I P T F L L R H E A W H F A R I V E L N I L G F L L P L A A I V F F N Y H I L A S L R T R E E V S R T R S K T T A L I L T L V V A F L V C W A P Y H F F A F L E F L F Q V Q G C F W E D F I D L G L Q L A N F F A F T N S S L N P V I Y V F V G R L V W E F R T K L Y K
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Residue Table


GPCRdb(A)
GPCRdb(A)
B1 receptor
TM1
1x28 1.28x28 W33
TM2
2x53 2.53x53 F86
2x60 2.60x60 W93
TM3
3x29 3.29x29 N114
3x32 3.32x32 I117
3x33 3.33x33 K118
3x36 3.36x36 L121
TM4
4x65 4.64x65 R176
ECL2
45x50 45.50x50 C189
45x51 45.51x51 I190
45x52 45.52x52 L191
TM5
5x39 5.38x39 R202
TM6
6x51 6.51x51 Y266
6x58 6.58x58 E273
6x61 6.61x61 F276
TM7
7x27 7.28x27 E287
7x31 7.32x31 D291
7x35 7.36x35 Q295
7x38 7.39x38 N298
7x39 7.40x39 F299
7x42 7.43x42 F302