Structure information

mGlu2 receptor

PROTEIN CLASS

Class C (Glutamate)

PDB CODE

7EPE

SPECIES

Homo sapiens

RESOLUTION

2.500

PREFERRED CHAIN

A

REFERENCE

10.1038/S41586-021-03641-W

PUBLICATION DATE

June 23, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL3894759 L639 3.36x36 TM3 hydrophobic
CHEMBL3894759 F643 3.40x40 TM3 hydrophobic
CHEMBL3894759 A726 ECL2 hydrophobic
CHEMBL3894759 S731 5.43x43 TM5 polar (hydrogen bond)
CHEMBL3894759 L732 5.44x44 TM5 hydrophobic
CHEMBL3894759 L732 5.44x44 TM5 Van der Waals
CHEMBL3894759 N735 5.47x47 TM5 Van der Waals
CHEMBL3894759 N735 5.47x47 TM5 polar (hydrogen bond)
CHEMBL3894759 W773 6.50x50 TM6 Van der Waals
CHEMBL3894759 W773 6.50x50 TM6 aromatic (face-to-edge)
CHEMBL3894759 L777 6.54x54 TM6 Van der Waals
CHEMBL3894759 F780 6.57x57 TM6 Van der Waals
CHEMBL3894759 F780 6.57x57 TM6 aromatic (face-to-edge)
CHEMBL3894759 Y781 6.58x58 TM6 Van der Waals
CHEMBL3894759 M794 7.32x33 TM7 Van der Waals
CHEMBL3894759 S797 7.35x36 TM7 polar (hydrogen bond)
CHEMBL3894759 S797 7.35x36 TM7 Van der Waals

Ligands

CHEMBL3894759

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Residue Diagrams

L T A L A G L C A I T V P G V A W A D G 1 Y I L L G G V F L C Y C M T F I F I A 2 T L L A S Y C V S F A T G L G L R R L T 3 Q V A I C L A L I S G Q L L I V V A W L 4 A Y L T C L A I L L V N Y A L S G L M S 5 G F T M Y T T C I I W L A F L P I F Y V 6 G L V V S G S L S V S V C M T T T Q V R 7
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ICL1 T N A P V V K A S ICL1ECL1 K P ECL1ICL2 A R E G A Q R P R F I ICL2ECL2 A P G T G K E T A P E R R E V V T L R C N H R ECL2ICL3 P E N ICL3ECL3 S ECL3N-term M G S L L A L L A L L L L W G A V A E G P A K K V L T L E G D L V L G G L F P V H Q K G G P A E D C G P V N E H R G I Q R L E A M L F A L D R I N R D P H L L P G V R L G A H I L D S C S K D T H A L E Q A L D F V R A S L S R G A D G S R H I C P D G S Y A T H G D A P T A I T G V I G G S Y S D V S I Q V A N L L R L F Q I P Q I S Y A S T S A K L S D K S R Y D Y F A R T V P P D F F Q A K A M A E I L R F F N W T Y V S T V A S E G D Y G E T G I E A F E L E A R A R N I C V A T S E K V G R A M S R A A F E G V V R A L L Q K P S A R V A V L F T R S E D A R E L L A A S Q R L N A S F T W V A S D G W G A L E S V V A G S E G A A E G A I T I E L A S Y P I S D F A S Y F Q S L D P W N N S R N P W F R E F W E Q R F R C S F R Q R D C A A H S L R A V P F E Q E S K I M F V V N A V Y A M A H A L H N M H R A L C P N T T R L C D A M R P V N G R R L Y K D F V L N V K F D A P F R P A D T H N E V R F D R F G D G I G R Y N I F T Y L R A G S G R Y R Y Q K V G Y W A E G L T L D T S L I P W A S P S A G P L P A S R C S E P C L Q N E V K S V Q P G E V C C W L C I P C Q P Y E Y R L D E F T C A D C G L G Y W P N A S L T G C F E L P Q E Y I R W N-termC-term S R F G S A A A R A S S S L G Q G S G S Q F V P T V C N G R E V V D S T T S S L C-term G D A W A V G P V T I A C L G A L A T L F V L G V F V R H G R E L C Y I L L G G V F L C Y C M T F I F I A S T A V C T L R R L G L G T A F S V C Y S A L L T K T N R I A R I F G G S P A S Q V A I C L A L I S G Q L L I V V A W L V V E D A S M L G S L A Y N V L L I A L C T L Y A F K T R K C F N E A K F I G F T M Y T T C I I W L A F L P I F Y V T S D Y R V Q T T T M C V S V S L S G S V V L G C L F A P K L H I I L F Q P Q K H R A N V V S P T
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Residue Table


GPCRdb(A)
GPCRdb(C)
mGlu2 receptor
TM3
3x32 3.36x36 L639
3x36 3.40x40 F643
TM5
5x43 5.43x43 S731
5x44 5.44x44 L732
5x47 5.47x47 N735
TM6
6x48 6.50x50 W773
6x52 6.54x54 L777
6x55 6.57x57 F780
6x56 6.58x58 Y781
TM7
7x38 7.32x33 M794
7x41 7.35x36 S797