Structure information

CCR5

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7F1Q

SPECIES

Homo sapiens

RESOLUTION

2.900

PREFERRED CHAIN

R

REFERENCE

PUBLICATION DATE

July 14, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
CCL3 C112 N-term polar (hydrogen bond)
CCL3 S113 N-term polar (hydrogen bond)
CCL3 S113 N-term polar (hydrogen bond with backbone)
CCL3 P115 N-term Van der Waals
CCL3 P115 N-term hydrophobic
CCL3 C116 N-term Van der Waals
CCL3 Q117 N-term Van der Waals
CCL3 K118 N-term polar (hydrogen bond with backbone)
CCL3 K118 N-term polar (charge-assisted hydrogen bond)
CCL3 K122 1.28x28 TM1 polar (charge-assisted hydrogen bond)
CCL3 W182 2.60x60 TM2 hydrophobic
CCL3 W182 2.60x60 TM2 Van der Waals
CCL3 T201 3.29x29 TM3 Van der Waals
CCL3 F205 3.33x33 TM3 Van der Waals
CCL3 F205 3.33x33 TM3 hydrophobic
CCL3 R264 ECL2 Van der Waals
CCL3 Q266 ECL2 polar (hydrogen bond)
CCL3 Q266 ECL2 polar (hydrogen bond)
CCL3 E268 ECL2 Van der Waals
CCL3 H271 ECL2 Van der Waals
CCL3 T273 ECL2 Van der Waals
CCL3 S275 45.51x51 ECL2 Van der Waals
CCL3 S275 45.51x51 ECL2 polar (hydrogen bond)
CCL3 S276 45.52x52 ECL2 polar (hydrogen bond with backbone)
CCL3 S276 45.52x52 ECL2 Van der Waals
CCL3 H277 ECL2 Van der Waals
CCL3 H277 ECL2 polar (hydrogen bond)
CCL3 F278 ECL2 hydrophobic
CCL3 F278 ECL2 Van der Waals
CCL3 Y280 ECL2 polar (hydrogen bond)
CCL3 Y280 ECL2 Van der Waals
CCL3 Y283 5.31x32 TM5 polar (hydrogen bond)
CCL3 Y283 5.31x32 TM5 Van der Waals
CCL3 K287 5.35x36 TM5 polar (charge-assisted hydrogen bond)
CCL3 Q290 5.38x39 TM5 polar (hydrogen bond)
CCL3 Q290 5.38x39 TM5 Van der Waals
CCL3 Y347 6.51x51 TM6 polar (hydrogen bond)
CCL3 Y347 6.51x51 TM6 polar (hydrogen bond)
CCL3 N354 6.58x58 TM6 polar (hydrogen bond)
CCL3 N354 6.58x58 TM6 Van der Waals
CCL3 Q357 ECL3 polar (hydrogen bond)
CCL3 Q357 ECL3 Van der Waals
CCL3 N363 ECL3 Van der Waals
CCL3 M375 7.35x34 TM7 polar (hydrogen bond)
CCL3 Q376 7.36x35 TM7 Van der Waals
CCL3 E379 7.39x38 TM7 polar (charge-assisted hydrogen bond)

Ligands

CCL3

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Residue Diagrams

M N G V F G F I F V L S Y L P P L L R A 1 L N L A I S D L F F L L T V P F W A H Y 2 L I I F F I G S F F G I F Y L G T L L Q 3 G V V T S V I T W V V A V F A S L P G 4 Y C I V M V L L P L V L G L I V I K L T Q 5 F T I M I V Y F L F W A P Y N I V L L L 6 I P N I C C H T M G L T E T V Q M A Q 7
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ICL1 K R L K ICL1ECL1 Q W D F ECL1ICL2 A V F A L K A R ICL2ECL2 R S Q K E G L H Y T C S S H F P Y S ECL2ICL3 R ICL3ECL3 L N ECL3N-term M D Y Q V S S P I Y D I N Y Y T S E P C Q N-termC-term K H I A K R F C K C C S I F Q Q E A P E R A S S V Y T R S T G E Q E I S V G L C-term K I N V K Q I A A R L L P P L Y S L V F I F G F V G N M L V I L I L I N C S M T D I Y L L N L A I S D L F F L L T V P F W A H Y A A A G N T M C Q L L T G L Y F I G F F S G I F F I I L L T I D R Y L A V V H T V T F G V V T S V I T W V V A V F A S L P G I I F T Q Y Q F W K N F Q T L K I V I L G L V L P L L V M V I C Y S G I L K T L L R C N E K K R H R A V R L I F T I M I V Y F L F W A P Y N I V L L L N T F Q E F F G N C S S S N R L D Q A M Q V T E T L G M T H C C I N P I I Y A F V G E K L L V F R N Y F F Q
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Residue Table


GPCRdb(A)
GPCRdb(A)
CCR5
TM1
1x28 1.28x28 K26
TM2
2x60 2.60x60 W86
TM3
3x29 3.29x29 T105
3x33 3.33x33 F109
ECL2
45x51 45.51x51 S179
45x52 45.52x52 S180
TM5
5x32 5.31x32 Y187
5x36 5.35x36 K191
5x39 5.38x39 Q194
TM6
6x51 6.51x51 Y251
6x58 6.58x58 N258
TM7
7x34 7.35x34 M279
7x35 7.36x35 Q280
7x38 7.39x38 E283