Structure information

MC1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7F4D

SPECIES

Homo sapiens

RESOLUTION

3.000

PREFERRED CHAIN

R

REFERENCE

10.1038/S41422-021-00557-Y

PUBLICATION DATE

Sept. 8, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
INTERMEDINE F45 1.39x39 TM1 hydrophobic
INTERMEDINE E94 2.60x60 TM2 polar (charge-assisted hydrogen bond)
INTERMEDINE T95 2.61x61 TM2 polar (hydrogen bond)
INTERMEDINE V97 2.63x63 TM2 Van der Waals
INTERMEDINE V97 2.63x63 TM2 hydrophobic
INTERMEDINE I98 2.64x64 TM2 hydrophobic
INTERMEDINE I98 2.64x64 TM2 Van der Waals
INTERMEDINE A110 3.18x18 TM3 Van der Waals
INTERMEDINE L113 3.21x21 TM3 Van der Waals
INTERMEDINE Q114 3.22x22 TM3 polar (hydrogen bond)
INTERMEDINE Q114 3.22x22 TM3 polar (hydrogen bond)
INTERMEDINE D117 3.25x25 TM3 polar (charge-assisted hydrogen bond)
INTERMEDINE N118 3.26x26 TM3 polar (hydrogen bond)
INTERMEDINE D121 3.29x29 TM3 polar (charge-assisted hydrogen bond)
INTERMEDINE T124 3.32x32 TM3 Van der Waals
INTERMEDINE C125 3.33x33 TM3 Van der Waals
INTERMEDINE C125 3.33x33 TM3 hydrophobic
INTERMEDINE M128 3.36x36 TM3 Van der Waals
INTERMEDINE M128 3.36x36 TM3 hydrophobic
INTERMEDINE F179 4.60x60 TM4 Van der Waals
INTERMEDINE I180 4.61x61 TM4 hydrophobic
INTERMEDINE I180 4.61x61 TM4 Van der Waals
INTERMEDINE Y183 ECL2 polar (hydrogen bond with backbone)
INTERMEDINE Y183 ECL2 Van der Waals
INTERMEDINE D184 ECL2 Van der Waals
INTERMEDINE L189 5.40x40 TM5 Van der Waals
INTERMEDINE L189 5.40x40 TM5 hydrophobic
INTERMEDINE L192 5.43x43 TM5 Van der Waals
INTERMEDINE F257 6.51x51 TM6 Van der Waals
INTERMEDINE F257 6.51x51 TM6 hydrophobic
INTERMEDINE H260 6.54x54 TM6 polar (hydrogen bond)
INTERMEDINE H260 6.54x54 TM6 Van der Waals
INTERMEDINE L261 6.55x55 TM6 Van der Waals
INTERMEDINE L261 6.55x55 TM6 hydrophobic
INTERMEDINE I264 6.58x58 TM6 Van der Waals
INTERMEDINE I264 6.58x58 TM6 hydrophobic
INTERMEDINE P268 ECL3 hydrophobic
INTERMEDINE P268 ECL3 Van der Waals
INTERMEDINE F277 ECL3 Van der Waals
INTERMEDINE F277 ECL3 hydrophobic
INTERMEDINE F280 7.35x34 TM7 hydrophobic
INTERMEDINE F280 7.35x34 TM7 Van der Waals
INTERMEDINE L284 7.39x38 TM7 hydrophobic
INTERMEDINE L284 7.39x38 TM7 Van der Waals

Ligands

INTERMEDINE

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Residue Diagrams

A N E V L S V L G L S L F L G D S 1 C C L A L S D L L V S G S N V L E T A V 2 A G L F C L S S L M S S C T I V D I V N 3 A R R A V A A I W V A S V V F S T L F I 4 Y L V A M L V L M A L F F V V L C L L V 5 T I L L G I F F L C W G P F F L H L T L 6 L P D I I A N C I I L A L F L N F N 7
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ICL1 R N L H ICL1ECL1 A L V A ECL1ICL2 A L R Y H S I V ICL2ECL2 Y D ECL2ICL3 R Q R P V H ICL3ECL3 P E H P T C G C I F K ECL3N-term M A V Q G S Q R R L L G S L N S T P T A I P Q L G L A A N Q T G A R C L E V S I N-termC-term L K E V L T C S W C-term S D G L F L S L G L V S L V E N A L V V A T I A K N S P M Y C F I C C L A L S D L L V S G S N V L E T A V I L L L E A G R A A V L Q Q L D N V I D V I T C S S M L S S L C F L G A I A V D R Y I S I F Y T L P R A R R A V A A I W V A S V V F S T L F I A Y H V A V L L C L V V F F L A M L V L M A V L Y V H M L A R A C Q H A Q G I A R L H K Q G F G L K G A V T L T I L L G I F F L C W G P F F L H L T L I V L C N F N L F L A L I I C N A I I D P L I Y A F H S Q E L R R T
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Residue Table


GPCRdb(A)
GPCRdb(A)
MC1 receptor
TM1
1x39 1.39x39 F45
TM2
2x60 2.60x60 E94
2x61 2.61x61 T95
2x63 2.63x63 V97
2x64 2.64x64 I98
TM3
3x18 3.18x18 A110
3x21 3.21x21 L113
3x22 3.22x22 Q114
3x25 3.25x25 D117
3x26 3.26x26 N118
3x29 3.29x29 D121
3x32 3.32x32 T124
3x33 3.33x33 C125
3x36 3.36x36 M128
TM4
4x60 4.60x60 F179
4x61 4.61x61 I180
TM5
5x40 5.40x40 L189
5x43 5.43x43 L192
TM6
6x51 6.51x51 F257
6x54 6.54x54 H260
6x55 6.55x55 L261
6x58 6.58x58 I264
TM7
7x34 7.35x34 F280
7x38 7.39x38 L284