Structure information

MC1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7F4F

SPECIES

Homo sapiens

RESOLUTION

2.900

PREFERRED CHAIN

R

REFERENCE

10.1038/S41422-021-00557-Y

PUBLICATION DATE

Sept. 8, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL407070 D42 1.36x36 TM1 polar (charge-assisted hydrogen bond)
CHEMBL407070 F45 1.39x39 TM1 aromatic (face-to-face)
CHEMBL407070 E94 2.60x60 TM2 polar (charge-assisted hydrogen bond)
CHEMBL407070 T95 2.61x61 TM2 Van der Waals
CHEMBL407070 I98 2.64x64 TM2 Van der Waals
CHEMBL407070 D117 3.25x25 TM3 polar (charge-assisted hydrogen bond)
CHEMBL407070 N118 3.26x26 TM3 Van der Waals
CHEMBL407070 N118 3.26x26 TM3 polar (hydrogen bond)
CHEMBL407070 D121 3.29x29 TM3 polar (charge-assisted hydrogen bond)
CHEMBL407070 T124 3.32x32 TM3 Van der Waals
CHEMBL407070 C125 3.33x33 TM3 hydrophobic
CHEMBL407070 C125 3.33x33 TM3 Van der Waals
CHEMBL407070 M128 3.36x36 TM3 hydrophobic
CHEMBL407070 M128 3.36x36 TM3 Van der Waals
CHEMBL407070 I180 4.61x61 TM4 Van der Waals
CHEMBL407070 I180 4.61x61 TM4 hydrophobic
CHEMBL407070 Y183 ECL2 polar (hydrogen bond with backbone)
CHEMBL407070 Y183 ECL2 Van der Waals
CHEMBL407070 L189 5.40x40 TM5 Van der Waals
CHEMBL407070 L189 5.40x40 TM5 hydrophobic
CHEMBL407070 L192 5.43x43 TM5 Van der Waals
CHEMBL407070 L192 5.43x43 TM5 hydrophobic
CHEMBL407070 F257 6.51x51 TM6 hydrophobic
CHEMBL407070 F257 6.51x51 TM6 Van der Waals
CHEMBL407070 H260 6.54x54 TM6 polar (hydrogen bond)
CHEMBL407070 H260 6.54x54 TM6 Van der Waals
CHEMBL407070 L261 6.55x55 TM6 hydrophobic
CHEMBL407070 L261 6.55x55 TM6 Van der Waals
CHEMBL407070 I264 6.58x58 TM6 hydrophobic
CHEMBL407070 I264 6.58x58 TM6 Van der Waals
CHEMBL407070 P268 ECL3 Van der Waals
CHEMBL407070 P268 ECL3 hydrophobic
CHEMBL407070 F277 ECL3 Van der Waals
CHEMBL407070 F277 ECL3 hydrophobic
CHEMBL407070 F280 7.35x34 TM7 hydrophobic
CHEMBL407070 F280 7.35x34 TM7 Van der Waals
CHEMBL407070 L284 7.39x38 TM7 Van der Waals
CHEMBL407070 L284 7.39x38 TM7 hydrophobic

Ligands

CHEMBL407070

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Residue Diagrams

A N E V L S V L G L S L F L G D S 1 C C L A L S D L L V S G S N V L E T A V 2 A G L F C L S S L M S S C T I V D I V N 3 A R R A V A A I W V A S V V F S T L F I 4 Y L V A M L V L M A L F F V V L C L L V 5 T I L L G I F F L C W G P F F L H L T L 6 L P D I I A N C I I L A L F L N F N 7
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ICL1 R N L H ICL1ECL1 A L V A ECL1ICL2 A L R Y H S I V ICL2ECL2 Y D ECL2ICL3 R Q R P V H ICL3ECL3 P E H P T C G C I F K ECL3N-term M A V Q G S Q R R L L G S L N S T P T A I P Q L G L A A N Q T G A R C L E V S I N-termC-term L K E V L T C S W C-term S D G L F L S L G L V S L V E N A L V V A T I A K N S P M Y C F I C C L A L S D L L V S G S N V L E T A V I L L L E A G R A A V L Q Q L D N V I D V I T C S S M L S S L C F L G A I A V D R Y I S I F Y T L P R A R R A V A A I W V A S V V F S T L F I A Y H V A V L L C L V V F F L A M L V L M A V L Y V H M L A R A C Q H A Q G I A R L H K Q G F G L K G A V T L T I L L G I F F L C W G P F F L H L T L I V L C N F N L F L A L I I C N A I I D P L I Y A F H S Q E L R R T
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Residue Table


GPCRdb(A)
GPCRdb(A)
MC1 receptor
TM1
1x36 1.36x36 D42
1x39 1.39x39 F45
TM2
2x60 2.60x60 E94
2x61 2.61x61 T95
2x64 2.64x64 I98
TM3
3x25 3.25x25 D117
3x26 3.26x26 N118
3x29 3.29x29 D121
3x32 3.32x32 T124
3x33 3.33x33 C125
3x36 3.36x36 M128
TM4
4x61 4.61x61 I180
TM5
5x40 5.40x40 L189
5x43 5.43x43 L192
TM6
6x51 6.51x51 F257
6x54 6.54x54 H260
6x55 6.55x55 L261
6x58 6.58x58 I264
TM7
7x34 7.35x34 F280
7x38 7.39x38 L284