Structure information

MC1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7F4I

SPECIES

Homo sapiens

RESOLUTION

3.100

PREFERRED CHAIN

R

REFERENCE

10.1038/S41422-021-00557-Y

PUBLICATION DATE

Sept. 8, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
bremelanotide F45 1.39x39 TM1 hydrophobic
bremelanotide E94 2.60x60 TM2 polar (charge-assisted hydrogen bond)
bremelanotide T95 2.61x61 TM2 polar (hydrogen bond)
bremelanotide V97 2.63x63 TM2 Van der Waals
bremelanotide I98 2.64x64 TM2 hydrophobic
bremelanotide I98 2.64x64 TM2 Van der Waals
bremelanotide L113 3.21x21 TM3 hydrophobic
bremelanotide D117 3.25x25 TM3 Van der Waals
bremelanotide D121 3.29x29 TM3 polar (charge-assisted hydrogen bond)
bremelanotide C125 3.33x33 TM3 Van der Waals
bremelanotide C125 3.33x33 TM3 hydrophobic
bremelanotide M128 3.36x36 TM3 Van der Waals
bremelanotide I180 4.61x61 TM4 Van der Waals
bremelanotide Y183 ECL2 polar (hydrogen bond with backbone)
bremelanotide Y183 ECL2 Van der Waals
bremelanotide L189 5.40x40 TM5 Van der Waals
bremelanotide L189 5.40x40 TM5 hydrophobic
bremelanotide L192 5.43x43 TM5 hydrophobic
bremelanotide L192 5.43x43 TM5 Van der Waals
bremelanotide F257 6.51x51 TM6 hydrophobic
bremelanotide F257 6.51x51 TM6 Van der Waals
bremelanotide H260 6.54x54 TM6 Van der Waals
bremelanotide L261 6.55x55 TM6 hydrophobic
bremelanotide L261 6.55x55 TM6 Van der Waals
bremelanotide I264 6.58x58 TM6 Van der Waals
bremelanotide F280 7.35x34 TM7 Van der Waals
bremelanotide F280 7.35x34 TM7 hydrophobic
bremelanotide L284 7.39x38 TM7 Van der Waals
bremelanotide L284 7.39x38 TM7 hydrophobic

Ligands

bremelanotide

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Residue Diagrams

A N E V L S V L G L S L F L G D S 1 C C L A L S D L L V S G S N V L E T A V 2 A G L F C L S S L M S S C T I V D I V N 3 A R R A V A A I W V A S V V F S T L F I 4 Y L V A M L V L M A L F F V V L C L L V 5 T I L L G I F F L C W G P F F L H L T L 6 L P D I I A N C I I L A L F L N F N 7
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ICL1 R N L H ICL1ECL1 A L V A ECL1ICL2 A L R Y H S I V ICL2ECL2 Y D ECL2ICL3 R Q R P V H ICL3ECL3 P E H P T C G C I F K ECL3N-term M A V Q G S Q R R L L G S L N S T P T A I P Q L G L A A N Q T G A R C L E V S I N-termC-term L K E V L T C S W C-term S D G L F L S L G L V S L V E N A L V V A T I A K N S P M Y C F I C C L A L S D L L V S G S N V L E T A V I L L L E A G R A A V L Q Q L D N V I D V I T C S S M L S S L C F L G A I A V D R Y I S I F Y T L P R A R R A V A A I W V A S V V F S T L F I A Y H V A V L L C L V V F F L A M L V L M A V L Y V H M L A R A C Q H A Q G I A R L H K Q G F G L K G A V T L T I L L G I F F L C W G P F F L H L T L I V L C N F N L F L A L I I C N A I I D P L I Y A F H S Q E L R R T
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Residue Table


GPCRdb(A)
GPCRdb(A)
MC1 receptor
TM1
1x39 1.39x39 F45
TM2
2x60 2.60x60 E94
2x61 2.61x61 T95
2x63 2.63x63 V97
2x64 2.64x64 I98
TM3
3x21 3.21x21 L113
3x25 3.25x25 D117
3x29 3.29x29 D121
3x33 3.33x33 C125
3x36 3.36x36 M128
TM4
4x61 4.61x61 I180
TM5
5x40 5.40x40 L189
5x43 5.43x43 L192
TM6
6x51 6.51x51 F257
6x54 6.54x54 H260
6x55 6.55x55 L261
6x58 6.58x58 I264
TM7
7x34 7.35x34 F280
7x38 7.39x38 L284