Structure information

MC4 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7F53

SPECIES

Homo sapiens

RESOLUTION

3.000

PREFERRED CHAIN

R

REFERENCE

10.1038/S41422-021-00552-3

PUBLICATION DATE

Nov. 3, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
α-MSH F51 1.39x39 TM1 aromatic (face-to-face)
α-MSH E100 2.60x60 TM2 polar (charge-assisted hydrogen bond)
α-MSH T101 2.61x61 TM2 Van der Waals
α-MSH I104 2.64x64 TM2 hydrophobic
α-MSH I104 2.64x64 TM2 Van der Waals
α-MSH T118 3.21x21 TM3 Van der Waals
α-MSH V119 3.22x22 TM3 hydrophobic
α-MSH V119 3.22x22 TM3 Van der Waals
α-MSH D122 3.25x25 TM3 polar (charge-assisted hydrogen bond)
α-MSH D126 3.29x29 TM3 polar (charge-assisted hydrogen bond)
α-MSH I129 3.32x32 TM3 Van der Waals
α-MSH I129 3.32x32 TM3 hydrophobic
α-MSH C130 3.33x33 TM3 Van der Waals
α-MSH C130 3.33x33 TM3 hydrophobic
α-MSH L133 3.36x36 TM3 hydrophobic
α-MSH L133 3.36x36 TM3 Van der Waals
α-MSH I185 4.61x61 TM4 Van der Waals
α-MSH I185 4.61x61 TM4 polar (hydrogen bond with backbone)
α-MSH S188 4.64x64 TM4 polar (hydrogen bond)
α-MSH I194 5.40x40 TM5 Van der Waals
α-MSH I194 5.40x40 TM5 hydrophobic
α-MSH L197 5.43x43 TM5 Van der Waals
α-MSH L197 5.43x43 TM5 hydrophobic
α-MSH F261 6.51x51 TM6 hydrophobic
α-MSH H264 6.54x54 TM6 Van der Waals
α-MSH H264 6.54x54 TM6 polar (hydrogen bond)
α-MSH L265 6.55x55 TM6 Van der Waals
α-MSH L265 6.55x55 TM6 hydrophobic
α-MSH Y268 6.58x58 TM6 Van der Waals
α-MSH Y268 6.58x58 TM6 aromatic (face-to-edge)
α-MSH Q273 ECL3 polar (hydrogen bond)
α-MSH Q273 ECL3 Van der Waals
α-MSH M281 ECL3 Van der Waals
α-MSH F284 7.35x34 TM7 hydrophobic
α-MSH F284 7.35x34 TM7 Van der Waals
α-MSH N285 7.36x35 TM7 polar (hydrogen bond)
α-MSH L288 7.39x38 TM7 hydrophobic
α-MSH L288 7.39x38 TM7 Van der Waals

Ligands

α-MSH

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Residue Diagrams

I N E L L S I V G L T V F V E P S 1 C S L A V A D M L V S V S N G S E T I V 2 S L L S C I S A L L S S C I V S D I V N 3 V G I I I S C I W A A C T V S G I L F I 4 Y L S A M L A L M T F F M T I L C I I V 5 T I L I G V F V V C W A P F F L H L I F 6 L P D I I S N C M I L I L Y L N F H 7
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ICL1 K N L H ICL1ECL1 N S T D T D A ECL1ICL2 A L Q Y H N I M ICL2ECL2 D ECL2ICL3 V L P G T G A I R ICL3ECL3 P Q N P Y C V C F M S ECL3N-term M V N S T H R G M H T S L H L W N R S S Y R L H S N A S E S L G K G Y S D G G C Y E Q L F V N-termC-term P L G G L C D L S S R Y C-term S P E V F V T L G V I S L L E N I L V I V A I A K N S P M Y F F I C S L A V A D M L V S V S N G S E T I V I T L L Q S F T V N I D N V I D S V I C S S L L A S I C S L L S I A V D R Y F T I F Y T V K R V G I I I S C I W A A C T V S G I L F I I Y S S S A V I I C L I T M F F T M L A L M A S L Y V H M F L M A R L H I K R I A Q G A N M K G A I T L T I L I G V F V V C W A P F F L H L I F Y I S C H F N L Y L I L I M C N S I I D P L I Y A L R S Q E F K E Y L R K T I I C C
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Residue Table


GPCRdb(A)
GPCRdb(A)
MC4 receptor
TM1
1x39 1.39x39 F51
TM2
2x60 2.60x60 E100
2x61 2.61x61 T101
2x64 2.64x64 I104
TM3
3x21 3.21x21 T118
3x22 3.22x22 V119
3x25 3.25x25 D122
3x29 3.29x29 D126
3x32 3.32x32 I129
3x33 3.33x33 C130
3x36 3.36x36 L133
TM4
4x61 4.61x61 I185
4x64 4.64x64 S188
TM5
5x40 5.40x40 I194
5x43 5.43x43 L197
TM6
6x51 6.51x51 F261
6x54 6.54x54 H264
6x55 6.55x55 L265
6x58 6.58x58 Y268
TM7
7x34 7.35x34 F284
7x35 7.36x35 N285
7x38 7.39x38 L288