Structure information

AT1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7F6G

SPECIES

Homo sapiens

RESOLUTION

2.900

PREFERRED CHAIN

A

REFERENCE

PUBLICATION DATE

March 29, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
SAR1-AngII Q15 N-term polar (hydrogen bond with backbone)
SAR1-AngII Q15 N-term Van der Waals
SAR1-AngII D16 N-term Van der Waals
SAR1-AngII D17 N-term Van der Waals
SAR1-AngII D17 N-term polar (hydrogen bond with backbone)
SAR1-AngII R23 N-term Van der Waals
SAR1-AngII W84 2.60x60 TM2 Van der Waals
SAR1-AngII W84 2.60x60 TM2 hydrophobic
SAR1-AngII Y87 2.63x63 TM2 Van der Waals
SAR1-AngII Y92 ECL1 Van der Waals
SAR1-AngII Y92 ECL1 hydrophobic
SAR1-AngII V108 3.32x32 TM3 hydrophobic
SAR1-AngII S109 3.33x33 TM3 Van der Waals
SAR1-AngII L112 3.36x36 TM3 hydrophobic
SAR1-AngII L112 3.36x36 TM3 Van der Waals
SAR1-AngII Y113 3.37x37 TM3 hydrophobic
SAR1-AngII R167 4.64x65 TM4 polar (charge-assisted hydrogen bond)
SAR1-AngII V179 ECL2 hydrophobic
SAR1-AngII A181 45.51x51 ECL2 hydrophobic
SAR1-AngII A181 45.51x51 ECL2 Van der Waals
SAR1-AngII F182 45.52x52 ECL2 polar (hydrogen bond with backbone)
SAR1-AngII F182 45.52x52 ECL2 Van der Waals
SAR1-AngII H183 ECL2 polar (hydrogen bond)
SAR1-AngII Y184 ECL2 Van der Waals
SAR1-AngII Y184 ECL2 polar (hydrogen bond with backbone)
SAR1-AngII K199 5.42x43 TM5 polar (charge-assisted hydrogen bond)
SAR1-AngII H256 6.51x51 TM6 Van der Waals
SAR1-AngII D263 6.58x58 TM6 polar (charge-assisted hydrogen bond)
SAR1-AngII I266 6.61x61 TM6 Van der Waals
SAR1-AngII D281 7.32x31 TM7 polar (charge-assisted hydrogen bond)
SAR1-AngII M284 7.35x34 TM7 Van der Waals
SAR1-AngII M284 7.35x34 TM7 hydrophobic
SAR1-AngII P285 7.36x35 TM7 Van der Waals
SAR1-AngII I288 7.39x38 TM7 Van der Waals
SAR1-AngII I288 7.39x38 TM7 hydrophobic

Ligands

SAR1-AngII

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Residue Diagrams

S N G F I G V V F I I S Y L T P I M V F 1 L N L A L A D L C F L L T L P L W A V Y 2 C T L L F V S A Y L N F S V S A S A I K 3 A K V T C I I I W L L A G L A S L P A 4 Y S T L I I L F P F L F G L I N K T L G L 5 M A I V L F F F F S W I P H Q I F T F L 6 L P N L C N N F Y A I C I T I P M A T 7
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ICL1 M K L K ICL1ECL1 Y R W P F ECL1ICL2 P M K S R L R R ICL2ECL2 N V F F I E N T N I T V C A F H Y E S Q N S T ECL2ICL3 Y E I Q K N K ICL3ECL3 I I R ECL3N-term M I L N S S T E D G I K R I Q D D C P K A G R N-termC-term P P K A K S H S N L S T K M S T L S Y R P S D N V S S S T K K P A P C F E V E C-term H N Y I F V M I P T L Y S I I F V V G I F G N S L V V I V I Y F Y T V A S V F L L N L A L A D L C F L L T L P L W A V Y T A M E G N Y L C K I A S A S V S F N L Y A S V F L L T C L S I D R Y L A I V H T M L V A K V T C I I I W L L A G L A S L P A I I H R L P I G L G L T K N I L G F L F P F L I I L T S Y T L I W K A L K K A P R N D D I F K I I M A I V L F F F F S W I P H Q I F T F L D V L I Q L G D C R I A D I V D T A M P I T I C I A Y F N N C L N P L F Y G F L G K K F L Q I F K R Y L L K Y
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Residue Table


GPCRdb(A)
GPCRdb(A)
AT1 receptor
TM2
2x60 2.60x60 W84
2x63 2.63x63 Y87
TM3
3x32 3.32x32 V108
3x33 3.33x33 S109
3x36 3.36x36 L112
3x37 3.37x37 Y113
TM4
4x65 4.64x65 R167
ECL2
45x51 45.51x51 A181
45x52 45.52x52 F182
TM5
5x43 5.42x43 K199
TM6
6x51 6.51x51 H256
6x58 6.58x58 D263
6x61 6.61x61 I266
TM7
7x31 7.32x31 D281
7x34 7.35x34 M284
7x35 7.36x35 P285
7x38 7.39x38 I288