Structure information

GIP receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

7FIN

SPECIES

Homo sapiens

RESOLUTION

3.100

PREFERRED CHAIN

R

REFERENCE

10.1038/S41467-022-28683-0

PUBLICATION DATE

Feb. 23, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Peptide-20 Q30 N-term polar (hydrogen bond with backbone)
Peptide-20 Q30 N-term Van der Waals
Peptide-20 T31 N-term Van der Waals
Peptide-20 A32 N-term Van der Waals
Peptide-20 L35 N-term hydrophobic
Peptide-20 L35 N-term Van der Waals
Peptide-20 Y36 N-term Van der Waals
Peptide-20 Y36 N-term hydrophobic
Peptide-20 W39 N-term Van der Waals
Peptide-20 W39 N-term aromatic (face-to-edge)
Peptide-20 M67 N-term Van der Waals
Peptide-20 M67 N-term hydrophobic
Peptide-20 Y68 N-term Van der Waals
Peptide-20 Y68 N-term hydrophobic
Peptide-20 Y87 N-term Van der Waals
Peptide-20 Y87 N-term hydrophobic
Peptide-20 W90 N-term Van der Waals
Peptide-20 W90 N-term hydrophobic
Peptide-20 R113 N-term polar (charge-assisted hydrogen bond)
Peptide-20 H115 N-term Van der Waals
Peptide-20 N120 N-term polar (hydrogen bond)
Peptide-20 F127 1.29x29 TM1 polar (hydrogen bond with backbone)
Peptide-20 F127 1.29x29 TM1 Van der Waals
Peptide-20 L128 1.30x30 TM1 Van der Waals
Peptide-20 R131 1.33x33 TM1 polar (charge-assisted hydrogen bond)
Peptide-20 L134 1.36x36 TM1 Van der Waals
Peptide-20 L134 1.36x36 TM1 hydrophobic
Peptide-20 E135 1.37x37 TM1 Van der Waals
Peptide-20 Q138 1.40x40 TM1 polar (hydrogen bond)
Peptide-20 Q138 1.40x40 TM1 polar (hydrogen bond)
Peptide-20 Y141 1.43x43 TM1 Van der Waals
Peptide-20 Y141 1.43x43 TM1 hydrophobic
Peptide-20 Y145 1.47x47 TM1 polar (hydrogen bond)
Peptide-20 Y145 1.47x47 TM1 polar (hydrogen bond)
Peptide-20 Y145 1.47x47 TM1 Van der Waals
Peptide-20 R183 2.60x60 TM2 Van der Waals
Peptide-20 I187 2.64x64 TM2 Van der Waals
Peptide-20 R190 2.67x67 TM2 Van der Waals
Peptide-20 P197 ECL1 hydrophobic
Peptide-20 P197 ECL1 Van der Waals
Peptide-20 P199 ECL1 hydrophobic
Peptide-20 P199 ECL1 Van der Waals
Peptide-20 V227 3.40x40 TM3 Van der Waals
Peptide-20 V227 3.40x40 TM3 hydrophobic
Peptide-20 E288 45.52x52 ECL2 polar (charge-assisted hydrogen bond)
Peptide-20 R289 ECL2 polar (charge-assisted hydrogen bond)
Peptide-20 N290 ECL2 Van der Waals
Peptide-20 N290 ECL2 polar (hydrogen bond with backbone)
Peptide-20 W296 5.36x37 TM5 Van der Waals
Peptide-20 W296 5.36x37 TM5 hydrophobic
Peptide-20 R370 7.35x34 TM7 polar (charge-assisted hydrogen bond)
Peptide-20 E377 7.42x41 TM7 Van der Waals
Peptide-20 I378 7.43x42 TM7 Van der Waals
Peptide-20 I378 7.43x42 TM7 hydrophobic

Ligands

Peptide-20

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Residue Diagrams

L L T A L S L S Y G V T Y M V Q L R E L 1 I N L F T S F M L R A A A I L S R D R L 2 V L L W T Y N A G V C Y Q T V I Q A T R 3 H F R Y Y L L G L W G A P A L F V I P W V 4 F I L F N I L I T M L I P T R I I W W I A 5 L T L V P L L G V H E V V F A P V 6 V S V L F G Q F S S L F I E F G L K A 7
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ICL1 R R L H ICL1ECL1 P R P G P Y L G D Q A L A L W N ECL1ICL2 V G G S E E G ICL2ECL2 N T Q C W E R N E V ECL2ICL3 Q M ICL3ECL3 T E E Q A R ECL3N-term M T T S P I L Q L L L R L S L C G L L L Q R A E T G S K G Q T A G E L Y Q R W E R Y R R E C Q E T L A A A E P P S G L A C N G S F D M Y V C W D Y A A P N A T A R A S C P W Y L P W H H H V A A G F V L R Q C G S D G Q W G L W R D H T Q C E N P E K N-termC-term Q L P E R A F R A L P S G S G P G E V P T S R G L S S G T L P G P G N E A S R E L E S Y C C-term N E A F L D Q R L I L E R L Q V M Y T V G Y S L S L A T L L L A L L I L S L F C T R N Y I H I N L F T S F M L R A A A I L S R D R L L Q A L A A C R T A Q I V T Q Y C V G A N Y T W L L V E G V Y L H S L L V L H F R Y Y L L L G W G A P A L F V I P W V I V R Y L Y E K A I W W I I R T P I L M T I L I N F L I F I R I L G I L L S K L R T R R C R D Y R L R L A R S T L T L V P L L G V H E V V F A P V G A L R F A K L G F E I F L S S F Q G F L V S V L Y C F I N K E I R R C R L G E E V Q S E G W H H R R S L Q R
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Residue Table


GPCRdb(A)
GPCRdb(B)
GIP receptor
TM1
1x25 1.29x29 F127
1x26 1.30x30 L128
1x29 1.33x33 R131
1x32 1.36x36 L134
1x33 1.37x37 E135
1x36 1.40x40 Q138
1x39 1.43x43 Y141
1x43 1.47x47 Y145
TM2
2x53 2.60x60 R183
2x57 2.64x64 I187
2x60 2.67x67 R190
TM3
3x36 3.40x40 V227
ECL2
45x52 45.52x52 E288
TM5
5x41 5.36x37 W296
TM7
7x30 7.35x34 R370
7x37 7.42x41 E377
7x38 7.43x42 I378