Structure information

GLP-1 receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

7LLY

SPECIES

Homo sapiens

RESOLUTION

3.300

PREFERRED CHAIN

R

REFERENCE

10.1038/S41467-021-27760-0

PUBLICATION DATE

Jan. 12, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Pro-glucagon V36 N-term hydrophobic
Pro-glucagon D67 N-term polar (hydrogen bond with backbone)
Pro-glucagon D67 N-term Van der Waals
Pro-glucagon L141 1.36x36 TM1 hydrophobic
Pro-glucagon L141 1.36x36 TM1 Van der Waals
Pro-glucagon L144 1.39x39 TM1 hydrophobic
Pro-glucagon L144 1.39x39 TM1 Van der Waals
Pro-glucagon Y145 1.40x40 TM1 hydrophobic
Pro-glucagon Y145 1.40x40 TM1 Van der Waals
Pro-glucagon K197 2.67x67 TM2 polar (charge-assisted hydrogen bond)
Pro-glucagon L201 2.71x71 TM2 Van der Waals
Pro-glucagon L201 2.71x71 TM2 hydrophobic
Pro-glucagon Y205 2.75x75 TM2 Van der Waals
Pro-glucagon Y205 2.75x75 TM2 polar (hydrogen bond)
Pro-glucagon Q234 3.37x37 TM3 Van der Waals
Pro-glucagon V237 3.40x40 TM3 Van der Waals
Pro-glucagon V237 3.40x40 TM3 hydrophobic
Pro-glucagon Y241 3.44x44 TM3 Van der Waals
Pro-glucagon Y241 3.44x44 TM3 hydrophobic
Pro-glucagon T298 45.52x52 ECL2 Van der Waals
Pro-glucagon R299 ECL2 polar (charge-assisted hydrogen bond)
Pro-glucagon N300 ECL2 Van der Waals
Pro-glucagon N300 ECL2 polar (hydrogen bond)
Pro-glucagon W306 5.36x37 TM5 Van der Waals
Pro-glucagon W306 5.36x37 TM5 hydrophobic
Pro-glucagon R310 5.40x40 TM5 Van der Waals
Pro-glucagon R380 7.35x34 TM7 polar (charge-assisted hydrogen bond)
Pro-glucagon L384 7.39x38 TM7 hydrophobic
Pro-glucagon L384 7.39x38 TM7 Van der Waals
Pro-glucagon E387 7.42x41 TM7 polar (charge-assisted hydrogen bond)
Pro-glucagon L388 7.43x42 TM7 Van der Waals

Ligands

Pro-glucagon

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Residue Diagrams

V L A S F S L A Y G V T Y I I Y L F L L 1 L N L F A S F I L R A L S V F I K D A A 2 V L L W Y Y N A A V C Y Q M L L F V L R 3 I F R L Y V S G I W G V P L L F V V P W G 4 F I L F N V G I A F L I P L R I I L W Y N 5 L T L I P L L G T H E V I F A F V M 6 I A V M L G Q F S T F S L E T F L K I 7
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ICL1 R H L H ICL1ECL1 T A A Q Q H Q W D G L L S Y Q D S ECL1ICL2 S V L ICL2ECL2 D E G C W T R N S ECL2ICL3 M ICL3ECL3 D E H A R ECL3N-term M A G A P G P L R L A L L L L G M V G R A G P R P Q G A T V S L W E T V Q K W R E Y R R Q C Q R S L T E D P P P A T D L F C N R T F D E Y A C W P D G E P G S F V N V S C P W Y L P W A S S V P Q G H V Y R F C T A E G L W L Q K D N S S L P W R D L S E C E E S K R G E R S S P N-termC-term S M K P L K C P T S S L S S G A T A G S S M Y T A T C Q A S C S C-term E E Q L L F L Y I I Y T V G Y A L S F S A L V I A S A I L L G F C T R N Y I H L N L F A S F I L R A L S V F I K D A A L K W M Y S L S C R L V F L L M Q Y C V A A N Y Y W L L V E G V Y L Y T L L A F S E Q W I F R L Y V S I G W G V P L L F V V P W G I V K Y L Y E N M N Y W L I I R L P I L F A I G V N F L I F V R V I C I V V S K L K A N L C K T D I K C R L A K S T L T L I P L L G T H E V I F A F V M G T L R F I K L F T E L S F T S F Q G L M V A I L Y C F V N N E F R K W R L I Q R V Q L E S W E R E H L H D S
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Residue Table


GPCRdb(A)
GPCRdb(B)
GLP-1 receptor
TM1
1x32 1.36x36 L141
1x35 1.39x39 L144
1x36 1.40x40 Y145
TM2
2x60 2.67x67 K197
2x64 2.71x71 L201
2x68 2.75x75 Y205
TM3
3x33 3.37x37 Q234
3x36 3.40x40 V237
3x40 3.44x44 Y241
ECL2
45x52 45.52x52 T298
TM5
5x41 5.36x37 W306
5x44 5.40x40 R310
TM7
7x30 7.35x34 R380
7x34 7.39x38 L384
7x37 7.42x41 E387
7x38 7.43x42 L388