Structure information

ghrelin receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7NA7

SPECIES

Homo sapiens

RESOLUTION

2.700

PREFERRED CHAIN

R

REFERENCE

10.1038/S41467-021-26735-5

PUBLICATION DATE

Dec. 15, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Ghrelin-27 L103 2.64x64 TM2 hydrophobic
Ghrelin-27 Y106 2.67x67 TM2 polar (hydrogen bond)
Ghrelin-27 Y106 2.67x67 TM2 Van der Waals
Ghrelin-27 R107 ECL1 polar (charge-assisted hydrogen bond)
Ghrelin-27 Q120 3.29x29 TM3 Van der Waals
Ghrelin-27 Q120 3.29x29 TM3 polar (hydrogen bond)
Ghrelin-27 S123 3.32x32 TM3 polar (hydrogen bond)
Ghrelin-27 E124 3.33x33 TM3 polar (charge-assisted hydrogen bond)
Ghrelin-27 Y128 3.37x37 TM3 Van der Waals
Ghrelin-27 I178 4.60x61 TM4 hydrophobic
Ghrelin-27 I178 4.60x61 TM4 Van der Waals
Ghrelin-27 E187 ECL2 polar (charge-assisted hydrogen bond)
Ghrelin-27 E197 ECL2 Van der Waals
Ghrelin-27 M213 5.39x39 TM5 hydrophobic
Ghrelin-27 M213 5.39x39 TM5 Van der Waals
Ghrelin-27 F279 6.51x51 TM6 Van der Waals
Ghrelin-27 F279 6.51x51 TM6 hydrophobic
Ghrelin-27 R283 6.55x55 TM6 polar (charge-assisted hydrogen bond)
Ghrelin-27 F286 6.58x58 TM6 hydrophobic
Ghrelin-27 F286 6.58x58 TM6 Van der Waals
Ghrelin-27 S289 6.61x61 TM6 Van der Waals
Ghrelin-27 F290 6.62x62 TM6 Van der Waals
Ghrelin-27 F290 6.62x62 TM6 polar (hydrogen bond with backbone)
Ghrelin-27 E291 6.63x63 TM6 Van der Waals
Ghrelin-27 P292 ECL3 Van der Waals
Ghrelin-27 A298 7.28x27 TM7 Van der Waals
Ghrelin-27 Q302 7.32x31 TM7 Van der Waals
Ghrelin-27 N305 7.35x34 TM7 polar (hydrogen bond)
Ghrelin-27 N305 7.35x34 TM7 polar (hydrogen bond)
Ghrelin-27 L306 7.36x35 TM7 Van der Waals
Ghrelin-27 L306 7.36x35 TM7 hydrophobic
Ghrelin-27 S308 7.38x37 TM7 polar (hydrogen bond with backbone)
Ghrelin-27 S308 7.38x37 TM7 Van der Waals
Ghrelin-27 F309 7.39x38 TM7 Van der Waals
Ghrelin-27 F309 7.39x38 TM7 aromatic (face-to-edge)
Ghrelin-27 F312 7.42x41 TM7 Van der Waals

Ligands

Ghrelin-27

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Residue Diagrams

L N G A I G V V F L A V C T A T V G A L 1 S S M A F S D L L I F L C M P L D L V R 2 A T I T L V T A Y T C S E S V F Q F L K 3 V K L V I F V I W A V A F C S A G P I 4 Y L V T L C F V P L F F F I S S V W V M 5 A V V V F A F I L C W L P F H V G R Y L 6 I P N I A A S L Y F L V F S V L N C Y 7
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ICL1 R E L R ICL1ECL1 R P W N F ECL1ICL2 P L R A K V V V ICL2ECL2 G V E H E N G T D P W D T N E C R P T E F A V R S ECL2ICL3 A V V G A ICL3ECL3 P G S ECL3N-term M W N A T P S E E P G F N L T L A D L D W D A S P G N D S L G D E L L Q L F N-termC-term F S Q R K L S T L K D E S S R A W T E S S I N T C-term P A P L L A G V T A T C V A L F V V G I A G N L L T M L V V S R F T T T N L Y L S S M A F S D L L I F L C M P L D L V R L W Q Y G D L L C K L F Q F V S E S C T Y A T V L T I T A L S V E R Y F A I C F T K G R V K L V I F V I W A V A F C S A G P I F V L V G L L T V M V W V S S I F F F L P V F C L T V L Y S L I G R K L W R R R R G D S L R D Q N H K Q T V K M L A V V V F A F I L C W L P F H V G R Y L F S K S F E L E I A Q I S Q Y C N L V S F V L F Y L S A A I N P I L Y N I M S K K V F R E P Y R V A L L G F
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Residue Table


GPCRdb(A)
GPCRdb(A)
ghrelin receptor
TM2
2x64 2.64x64 L103
2x67 2.67x67 Y106
TM3
3x29 3.29x29 Q120
3x32 3.32x32 S123
3x33 3.33x33 E124
3x37 3.37x37 Y128
TM4
4x61 4.60x61 I178
TM5
5x39 5.39x39 M213
TM6
6x51 6.51x51 F279
6x55 6.55x55 R283
6x58 6.58x58 F286
6x61 6.61x61 S289
6x62 6.62x62 F290
6x63 6.63x63 E291
TM7
7x27 7.28x27 A298
7x31 7.32x31 Q302
7x34 7.35x34 N305
7x35 7.36x35 L306
7x37 7.38x37 S308
7x38 7.39x38 F309
7x41 7.42x41 F312