Structure information

MRGPRX2

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7S8N

SPECIES

Homo sapiens

RESOLUTION

2.900

PREFERRED CHAIN

R

REFERENCE

10.1038/S41586-021-04126-6

PUBLICATION DATE

Nov. 17, 2021
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Ligand Interaction Browser

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LigandAmino AcidGeneric NumberSegmentInteraction Type
Ligand
Amino Acid
Generic Number
Segment
Interaction Type
Ligand
Amino Acid
Generic Number
Segment
Interaction Type
(R)-ZINC-3573 F170 ECL2 hydrophobic
(R)-ZINC-3573 D184 5.40x40 TM5 polar (charge-assisted hydrogen bond)
(R)-ZINC-3573 W243 6.55x55 TM6 hydrophobic
(R)-ZINC-3573 W243 6.55x55 TM6 Van der Waals
(R)-ZINC-3573 W248 6.60x60 TM6 hydrophobic
(R)-ZINC-3573 W248 6.60x60 TM6 Van der Waals
LigandAmino AcidGeneric NumberSegmentInteraction Type
Showing 1 to 6 of 6 entries

Ligands

(R)-ZINC-3573

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Residue Diagrams

G N G V L G V L A I F L I L F V P I L T 1 L S L A G A D F L F L C F Q I I N C L V 2 T S L M S L G A L Y A C T M V T T F F S 3 S A V V C V L L W A L S L L L S I L E G 4 S S G C L V M F L F I L W A A T I F D F 5 L L T V L V F L L C G L P F G I Q W F L 6 I P N A S S N L S S L V V S V P H I H 7
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ICL1 ECL1 ICL2 ECL2 ICL3 ECL3 N-term C-term T L I P V F L I L F I A L V G L V G N G F V L W L L G F R M N A F S V Y V L S L A G A D F L F L C F Q I I N C L V Y L S N F F C S P S F F T T V M T C A Y L A G L S M L S T V S T E R C L S V L W P R H L S A V V C V L L W A L S L L L S I L E G K F C D S G W C Q T F D F I T A A W L I F L F M V L C G S S L A L L V R I L C G P L T R L Y L T I L L T V L V F L L C G L P F G I Q W F L I L W I W L F C H I H P V S V V L S S L N S S A N P I I Y F F V G S F
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Residue Table


GPCRdb(A)
GPCRdb(A)
MRGPRX2
TM5
5x40 5.40x40 D184
TM6
6x55 6.55x55 W243
6x60 6.60x60 W248