Structure information

5-HT2B receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7SRQ

SPECIES

Homo sapiens

RESOLUTION

2.700

PREFERRED CHAIN

R

REFERENCE

10.1016/J.NEURON.2022.08.006

PUBLICATION DATE

Sept. 21, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Lysergide D135 3.32x32 TM3 polar (charge-assisted hydrogen bond)
Lysergide V136 3.33x33 TM3 hydrophobic
Lysergide W337 6.48x48 TM6 Van der Waals
Lysergide F340 6.51x51 TM6 hydrophobic
Lysergide F340 6.51x51 TM6 Van der Waals
Lysergide F341 6.52x52 TM6 aromatic (edge-to-face)
Lysergide N344 6.55x55 TM6 Van der Waals
Lysergide V366 7.39x38 TM7 hydrophobic
Lysergide V366 7.39x38 TM7 Van der Waals

Ligands

Lysergide

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Residue Diagrams

T N G G I T P I I V M L I L L A A W H L K 1 M S L A V A D L L V G F L V M P I A L L T 2 A C L H M I S A T S F L V D L F L W A P 3 A F I K I T V V W L I S I G I A I P V 4 Y T V I M I A L P T F F A A L S G F L M F 5 G I V F F L F L L M W C P F F I T N I T 6 L P N V G S S V Y G I W V F I E L L M 7
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ICL1 K K L Q ICL1ECL1 E A M W P L ECL1ICL2 P I Q A N Q Y N ICL2ECL2 I E T D V D N P N N I T C V L T K E R ECL2ICL3 P Q R L T W L T V S T V F Q R D E T P C S S P E K V A M L D G S R K D K A L P N S G D E T L M R R T S T I G K K S ICL3ECL3 D S C ECL3N-term M A L S Y R V S E L Q S T I P E H I L Q S T F V H V I S S N W S G L Q T E S I P E E M K Q I V E E Q G N N-termC-term T C N Y R A T K S V K T L R K R S S K I Y F R N P M A E N S K F F K K H G I R N G I N P A M Y Q S P M R L R S S T I Q S S S I I L L D T L L L T E N E G D K T E E Q V S Y V C-term K L H W A A L L I L M V I I P T I G G N T L V I L A V S L E Y A T N Y F L M S L A V A D L L V G L F V M P I A L L T I M F P L V L C P A W L F L D V L F S T A S I M H L C A I S V D R Y I A I K K S R A T A F I K I T V V W L I S I G I A I P V P I K G F G D F M L F G S L A A F F T P L A I M I V T Y F L T I H A L Q K K A Y L V K N K P V Q T I S N E Q R A S K V L G I V F F L F L L M W C P F F I T N I T L V L C N Q T T L Q M L L E I F V W I G Y V S S G V N P L V Y T L F N K T F G R F R D A Y I
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Residue Table


GPCRdb(A)
GPCRdb(A)
5-HT2B receptor
TM3
3x32 3.32x32 D135
3x33 3.33x33 V136
TM6
6x48 6.48x48 W337
6x51 6.51x51 F340
6x52 6.52x52 F341
6x55 6.55x55 N344
TM7
7x38 7.39x38 V366