Structure information

5-HT5A receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7UM5

SPECIES

Homo sapiens

RESOLUTION

2.730

PREFERRED CHAIN

A

REFERENCE

10.1038/S41594-022-00796-6

PUBLICATION DATE

July 20, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
5-CT D121 3.32x32 TM3 polar (charge-assisted hydrogen bond)
5-CT V122 3.33x33 TM3 hydrophobic
5-CT V122 3.33x33 TM3 Van der Waals
5-CT C125 3.36x36 TM3 Van der Waals
5-CT T126 3.37x37 TM3 Van der Waals
5-CT T126 3.37x37 TM3 polar (hydrogen bond)
5-CT S204 5.42x43 TM5 polar (hydrogen bond)
5-CT S204 5.42x43 TM5 Van der Waals
5-CT F301 6.51x51 TM6 Van der Waals
5-CT F301 6.51x51 TM6 hydrophobic
5-CT F302 6.52x52 TM6 Van der Waals
5-CT F302 6.52x52 TM6 aromatic (edge-to-face)
5-CT E305 6.55x55 TM6 polar (charge-assisted hydrogen bond)
5-CT Y328 7.43x42 TM7 Van der Waals

Ligands

5-CT

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Residue Diagrams

L N W A F T A A V L F G L L T L I L V G 1 A S M A V S D V L V A L A V M P L S L V H 2 A T V N W I S A T C C L V D C A I W L Q 3 S N V M I A L T W A L S A V I S L A P L 4 Y V F L V V C L P L Y F A G V T S F V A Y 5 G I L I G V F V L C W I P F F L T E L I 6 L P N F F S N S Y G L W L F I S K W I 7
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ICL1 R T F H ICL1ECL1 R R W Q L ECL1ICL2 H M E Y T ICL2ECL2 W G E T Y S E G S E E C Q V S R ECL2ICL3 V S P I S E A V E V K D S A K Q P Q M V F T V R H A T V T F Q P E G D ICL3ECL3 S C D I ECL3N-term M D L P V N L T S F S L S T P S P L E T N H S L G K D D L R P S S P L N-termC-term S R Q H C-term L S V F G V L I L T L L G F L V A A T F A W N L L V L A T I L R V R V P H N L V A S M A V S D V L V A A L V M P L S L V H E L S G G R R L C Q L W I A C D V L C C T A S I W N V T A I A L D R Y W S I T R L R T R K C V S N V M I A L T W A L S A V I S L A P L L F G E P S Y A V F S T V G A F Y L P L C V V L F V Y W K I Y K A A K F R V G S R K T N S T W R E Q K E Q R A A L M V G I L I G V F V L C W I P F F L T E L I S P L C P A I W K S I F L W L G Y S N S F F N P L I Y T A F N K N F K N Y N S A F F
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Residue Table


GPCRdb(A)
GPCRdb(A)
5-HT5A receptor
TM3
3x32 3.32x32 D121
3x33 3.33x33 V122
3x36 3.36x36 C125
3x37 3.37x37 T126
TM5
5x43 5.42x43 S204
TM6
6x51 6.51x51 F301
6x52 6.52x52 F302
6x55 6.55x55 E305
TM7
7x42 7.43x42 Y328